Faculty Profiles - WEN Zilong | The Hong Kong University of Science and Technology

Zilong WEN
温子龍

PhD in Molecular Cell Biology
The Rockefeller University, 1997

Professor
Division of Life Science

(852) 2358 7294
zilong@ust.hk
Room 5449
Personal Web

Google Scholar

1h4-21YAAAAJ

ORCID

0000-0002-4260-7682

Scopus ID

55630978700

Research Interest Publications Projects Teaching Assignment RPG Supervision Space used

Research Interest

Developmental biology
Immunology
Genetics
Cell development
Cell signaling

Publications

All Years 97 2023 4 2022 4 2021 3 2020 5 2019 4 2018 3 2017 74

2023 4

Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia

Science Advances, v. 9, (24), June 2023, article number eadf9790
Yu, Tao; Kuang, Haoyue; Wu, Xiaohai; Huang, Ying; Wang, Jianzhong; Wen, Zilong
Article

Cross-organ single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish

Cell Reports, v. 42, (7), July 2023, article number 112793
Zhou, Qiuxia; Zhao, Changlong; Yang, Zhiyong; Qu, Rui; Li, Yunbo; Fan, Yining; Tang, Jinlin; Xie, Ting; Wen, Zilong
Article

Metaphocytes are IL-22BP-producing cells regulated by ETS transcription factor Spic and essential for zebrafish barrier immunity

Cell Reports, v. 42, (5), May 2023, article number 112483
Zhao, Changlong; Li, Yunbo; Tang, Jinlin; Zhou, Qiuxia; Lin, Xi; Wen, Zilong
Article

Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

eLife, May 2023, article number eLife.87434.1
Chen, Xianwei; Li, Yanfeng; Xu, Jin; Cui, Yong; Wu, Qian; Yin, Haidi; Li, Yuying; Jiang, Liwen; Wang, Huating; Wen, Zilong; Yao, Zhongping; Wu, Zhenguo
Article

2022 4

Csf1rb regulates definitive hematopoiesis in zebrafish

Development, v. 149, (16), August 2022, article number dev200534
Dai, Yimei; Wu, Shuting; Cao, Canran; Xue, Rongtao; Luo, Xuefen; Wen, Zilong; Xu, Jin
Article

Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage

Proceedings of the National Academy of Sciences of the United States of America, v. 119, (13), March 2022, article number e2119051119
Zhao, Shizheng; Feng, Shachuan; Tian, Ye; Wen, Zilong
Article

Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression

Proceedings of the National Academy of Sciences of the United States of America, v. 119, (39), September 2022, article number e2203273119
Lou, Liang; Yu, Tao; Dai, Yimei; Zhao, Shizheng; Feng, Shachuan; Xu, Jin; Wen, Zilong
Article

The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish

Development, v. 149, (19), October 2022, article number dev200881
Zhao, Shizheng; Zhang, Ao; Zhu, Hao; Wen, Zilong
Article

2021 3

De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation

Circulation Research, v. 129, (9), October 2021, p. 825-839
Li, Hao; Nam, Yoonhee; Huo, Ran; Fu, Weilun; Jiang, Biaobin; Zhou, Qiuxia; Song, Dong; Yang, Yingxi; Jiao, Yuming; Weng, Jiancong; Yan, Zihan; Di, Lin; Li, Jie; Wang, Jie; Xu, Hongyuan; Wang, Shuo; Zhao, Jizong; Wen, Zilong; Wang, Jiguang; Cao, Yong
Article

Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish

Science China Life Sciences, 16 March 2021
Chen, Jiakui; Li, Gaofei; Lian, Junwei; Ma, Ning; Huang, Zhibin; Li, Jianchao; Wen, Zilong; Zhang, Wenqing; Zhang, Yiyue
Article

The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway

Cell Death & Disease, v. 12, (10), October 2021, article number 906
Zhao, Yan; Wu, Mei; Li, Jing; Meng, Ping; Chen, Jiakui; Huang, Zhibin; Xu, Jin; Wen, Zilong; Zhang, Wenqing; Zhang, Yiyue
Article

2020 5

Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity

Cell Reports, v. 33, (1), 6 October 2020, article number 108227
Lin, Xi; Zhou, Qiuxia; Lin, Guanzhen; Zhao, Changlong; Wen, Zilong
Article

In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy

eLife, v. 9, January 2020, article number e52024
He, Sicong; Tian, Ye; Feng, Shachuan; Wu, Yi; Shen, Xinwei; Chen, Kani; He, Yingzhu; Sun, Qiqi; Li, Xuesong; Xu, Jin; Wen, Zilong; Qu, Jianan
Article

Lightening the Way of Hematopoiesis: Infrared Laser-Mediated Lineage Tracing With High Spatial-Temporal Resolution

Experimental Hematology, v. 85, May 2020, p. 3-7
He, Sicong; Xu, Jin; Qu, Jianan; Wen, Zilong
Article

Tripartite-Motif Family Protein 35-28 Regulates Microglia Development by Preventing Necrotic Death of Microglial Precursors in Zebrafish

The Journal of Biological Chemistry, v. 295, (26), June 2020, p. 8846-8856
Yu, Tao; Kuang, Haoyue; Chen, Jiahao; Lin, Xi; Wu, Yi; Chen, Keyu; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong
Article

Two phenotypically and functionally distinct microglial populations in adult zebrafish

Science Advances, v. 6, (47), November 2020, article number eabd1160
Wu, Shuting; Nguyen, Linh T. M.; Pan, Hongru; Hassan, Shaoli; Dai, Yimei; Xu, Jin; Wen, Zilong
Article

2019 4

An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis

Developmental Cell, v. 49, (4), May 2019, p. 605-617.e5
Lin, Xi; Zhou, Qiuxia; Lin, Guanzhen; Xu, Jin; Wen, Zilong
Article

Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish

iScience, v. 13, March 2019, p. 391-401
Jin, Wan; Dai, Yimei; Li, Funing; Zhu, Lu; Huang, Zhibin; Liu, Wei; Li, Jianchao; Zhang, Mingjie; Du, Jiulin; Zhang, Wenqing; Wen, Zilong
Article

Nlrc3-like is required for microglia maintenance in zebrafish

Journal of Genetics and Genomics, v. 46, (6), June 2019, p. 291-299
Wang, Tienan; Yan, Bo; Lou, Liang; Lin, Xi; Yu, Tao; Wu, Shuting; Lu, Qing; Liu, Wei; Huang, Zhibin; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong
Article

Tissue-resident macrophages: from zebrafish to mouse

Blood Science, v. 1, (1), August 2019, p. 57-60
Lin, Xi; Wen, Zilong; Xu, Jin
Article

2018 3

Adult Zebrafish Langerhans Cells Arise from Hematopoietic Stem/Progenitor Cells

eLIFE, v. 7, June 2018, article number e36131
He, Sicong; Chen, Jiahao; Jiang, Yunyun; Wu, Yi; Zhu, Lu; Jin, Wan; Zhao, Changlong; Yu, Tao; Wang, Tienan; Wu, Shuting; Lin, Xi; Qu, Jianan; Zhang, Wenqing; Wen, Zilong; Xu, Jin
Article

Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial Precursors

Developmental Cell, v. 46, (5), September 2018, p. 552-563.e4
Wu, Shuting; Xue, Rongtao; Hassan, Shaoli; Nguyen, Thi My Linh; Wang, Tienan; Pan, Hongru; Xu, Jin; Liu, Qifa; Zhang, Wenqing; Wen, Zilong
Article

Labeling single cell for in-vivo study of cell fate mapping and lineage tracing

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 10497, 2018, article number 104970J
He, Sicong; Xu, Jin; Wu yi; Tian, Ye; Sun, Qiqi; Wen, Zilong; Qu, Jianan
Conference paper

2017 4

C-Myb Hyperactivity Leads to Myeloid and Lymphoid Malignancies in Zebrafish

Leukemia, v. 31, (1), January 2017, p. 222-233
Liu, Wei; Wu, M.; Huang, Z.; Lian, J.; Chen, J.; Wang, Tienan; Leung, A.Y.H.; Liao, Y.; Zhang, Zhang Jin; Liu, Qifa; Yen, K.; Lin, S.; Zon, Leonard I.; Wen, Zilong; Zhang, Yunfan; Zhang, Wenqing
Article

Distinct Regulatory Networks Control the Development of Macrophages of Different Origins in Zebrafish

Blood, v. 129, (4), January 2017, p. 509-519
Yu, Tao; Guo, Weilin; Tian, Ye; Xu, Jin; Chen, Jiahao; Li, Li; Wen, Zilong
Article

The First Wave of T Lymphopoiesis in Zebrafish Arises from Aorta Endothelium Independent of Hematopoietic Stem Cells

Journal of Experimental Medicine, v. 214, (11), November 2017, p. 3347-3360
Tian, Ye; Xu, Jin; Feng, Shachuan; He, Sicong; Zhao, Shizheng; Zhu, Lu; Jin, Wan; Dai, Yimei; Luo, Lingfei; Qu, Jianan Y.; Wen, Zilong
Article

NME7 Functions in ciliogenesis and left-right asymmetry development

Liu, Pengfei; Yu, Tao; Wen, Zilong; Qi, Robert Zhong
Conference paper

2016 6

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish

Journal of Genetics and Genomics, v. 43, (10), October 2016, p. 593-600
Dai, Yimei; Zhu, Lu; Huang, Zhibin; Zhou, Minyu; Jin, Wan; Liu, Wei; Xu, Mengchang; Yu, Tao; Zhang, Yiyue; Wen, Zilong; Liao, Wangjun; Zhang, Wenqing
Article

c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish

Blood, v. 128, (3), July 2016, p. 415-426
Jin, Hao; Huang, Zhibin; Chi, Yali; Wu, Mei; Zhou, Riyang; Zhao, Lingfeng; Xu, Jin; Zhen, Fenghua; Lan, Yahui; Li, Li; Zhang, Wenqing; Wen, Zilong; Zhang, Yiyue
Article

Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine

Developmental Cell, v. 38, (2), July 2016, p. 214-222
Xu, Jin; Wang, Tienan; Wu, Yi; Jin, Wan; Wen, Zilong
Article

Real-Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria-Targeting AIE Fluorogen

Advanced Functional Materials, v. 26, (39), October 2016, p. 7132-7138
Situ, Bo; Chen, Sijie; Zhao, Engui; Leung, Wai Tung; Chen, Yilong; Hong, Yuning; Lam, Wing Yip; Wen, Zilong; Liu, Wei; Zhang, Wenqing; Zheng, Lei; Tang, Benzhong
Article

RNA Polymerase III Component Rpc9 Regulates Hematopoietic Stem and Progenitor Cell Maintenance in Zebrafish

Development (Cambridge), v. 143, (12), June 2016, p. 2103-2110
Wei, Yonglong; Xu, Jin; Zhang, Wenqing; Wen, Zilong; Liu, Feng
Article

Origin of Microglia in Brain: A Study in Zebrafish Model

Biomedical Optics Congress 2016 / Optica Publishing Group. Florida United States : Optica Publishing Group, 2016, Paper BTh2D.3
He, Sicong; Xu, Jin; Wen, Zilong; Qu, Jianan
Conference paper

2015 3

Functions of Idh1 and Its Mutation in the Regulation of Developmental Hematopoiesis in Zebrafish

Blood, v. 125, (19), May 2015, p. 2974-2984
Shi, Xiangguo; He, Bai-Liang; Ma, Alvin C.H.; Guo, Yuhan; Chi, Yali; Man, Cheuk Him; Zhang, Wenqing; Zhang, Yiyue; Wen, Zilong; Cheng, Tao; Leung, Anskar Y.H.
Article

Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish

Scientific Reports, v. 5, March 2015, article number 9011
Yuan, Hao; Zhang, Tao; Liu, Xiaohui; Deng, Min; Zhang, Wenqing; Wen, Zilong; Chen, Saijuan; Chen, Zhu; De The, Hugues; Zhou, Jun; Zhu, Jun
Article

Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

Developmental Cell, v. 34, (6), September 2015, p. 632-641
Xu, Jin; Zhu, Lu; He, Sicong; Wu, Yi; Jin, Wan; Yu, Tao; Qu, Jianan Y.; Wen, Zilong
Article

2014 4

IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and basal random motility in a zebrafish injury-induced inflammation model

Journal of Immunology, v. 192, (12), June 2014, p. 5998-6008
Yan, Bo; Han, Peidong; Pan, Lifeng; Lu, Wei; Xiong, Jingwei; Zhang, Mingjie; Zhang, Wenqing; Li, Li; Wen, Zilong
Article

In Vivo Micro-Vascular Imaging and Flow Cytometry in Zebrafish Using Two-photon Excited Endogenous Fluorescence

Biomedical Optics Express, v. 5, (3), 2014, p. 653-663
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan
Article

In Vivo Nonlinear Optical Imaging of Immune Responses: Tissue Injury and Infection

Biophysical Journal, v. 107, (10), 2014, p. 2436-2443
Zeng, Yan; Yan, Bo; Xu, Jin; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan
Article

Nonlinear optical microscopy for in vivo imaging microvasculature and blood flow

Conference Proceedings: Biomedical Optics, 2014, article number BM4A.2
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan
Conference paper

2013 4

Hemogenic Endothelium Specification and Hematopoietic Stem Cell Maintenance Employ Distinct Scl Isoforms

Development (Cambridge), v. 140, (19), October 2013, p. 3977-3985
Zhen, Fenghua; Lan, Yahui; Yan, Bo; Zhang, Wenqing; Wen, Zilong
Article

Label-Free in Vivo Imaging of Human Leukocytes Using Two-photon Excited Endogenous Fluorescence

Journal of Biomedical Optics, v. 18, (4), 2013, article number 040504
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan
Article

Suppression of Pu.1 Function Results in Expanded Myelopoiesis in Zebrafish

Leukemia, v. 27, (9), September 2013, p. 1913-1917
Sun, Jiping; Liu, Wei; Li, Li; Chen, Jiahao; Wu, Mei; Zhang, Yiyue; Leung, Anskar; Zhang, Wenqing; Wen, Zilong; Liao, Wangjun
Article

Two-Photon Excited Endogenous Fluorescence for Label-Free in Vivo Imaging Ingestion of Disease-Causing Bacteria by Human Leukocytes

SPIE Proceedings, v. 8588, February 2013
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan
Conference paper

2012 8

Antiparallel Coiled-coil-mediated Dimerization of Myosin X

Proceedings of the National Academy of Sciences of the United States of America, v. 109, (43), 2012, Oct, p. 17388-17393
Lu, Qing; Ye, Fei; Wei, Zhiyi; Wen, Zilong; Zhang, Mingjie
Article

Label-free in Vivo Flow Cytometry in Zebrafish Using Two-photon Autofluorescence Imaging

Optics Letters, v. 37, (13), 2012, Jul, p. 2490-2492
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan
Article

Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration

Journal of Biological Chemistry, v. 287, (30), 2012, Jul, p. 25353-25360
Li, Li; Yan, Bo; Shi, Yu-Qian; Zhang, Wen-Qing; Wen, Zi-Long
Article

Myelopoiesis during Zebrafish Early Development

Journal of Genetics and Genomics, v. 39, (9), 2012, Sep, p. 435-442
Xu, Jin; Du, Linsen; Wen, Zilong
Article

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

Developmental cell, v. 23, (6), December 2012, p. 1189-1202
Li, Ying; Du, Xu-fei; Liu, Chang-sheng; Wen, Zi-long; Du, Jiu-lin
Article

Runx1 Regulates Embryonic Myeloid Fate Choice in Zebrafish Through a Negative Feedback Loop Inhibiting Pu.1 Expression

Blood, v. 119, (22), 2012, Jun, p. 5239-5249
Jin, Hao; Li, Li; Xu, Jin; Zhen, Fenghua; Zhu, Lu; Liu, Pu Paul; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong
Article

SUMO1-activating Enzyme Subunit 1 Is Essential for the Survival of Hematopoietic Stem/Progenitor Cells in Zebrafish

Development (Cambridge), v. 139, (23), 2012, Dec, p. 4321-4329
Li, Xiuling; Lan, Yahui; Xu, Jin; Zhang, Wenqing; Wen, Zilong
Article

In vivo cytometry using two-photon autofluorescence microscopy

Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America), Miami, Florida, United States, 28 Apr - 2 May, 2012
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan
Conference paper

2011 4

CMyb Regulates Hematopoietic Stem/Progenitor Cell Mobilization during Zebrafish Hematopoiesis

Blood, v. 118, (15), 2011, Oct, p. 4093-4101
Zhang, Yiyue; Jin, H.; Li, L.; Qin, F.X.F.; Wen, Z.
Article

Erythrocytes in the trunk of zebrafish embryos

Development, v. 138, (18), September 2011, p. 3862-3863
Jin, Hao; Wen, Zilong
Article

Irf8 Regulates Macrophage Versus Neutrophil Fate During Zebrafish Primitive Myelopoiesis

Blood, v. 117, (4), 2011, p. 1359-1369
Li, Li; Jin, Hao; Xu, Jin; Shi, Yuqian; Wen, Zilong
Article

Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis

Development, v. 138, (4), 2011, Jan, p. 619-629
Du, Linsen; Xu, J.; Li, Xiuling; Ma, Ning; Liu, Yanmei; Peng, Jinrong; Osato, Motomi; Zhang, Wenqing; Wen, Zilong
Article

2010 3

A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells

Stem Cells, v. 28, (10), 2010, p. 1869-1881
Ng, Cherry Ee Lin; Yokomizo, Tomomasa; Yamashita, Namiko; Cirovic, Branko; Jin, Hao; Wen, Zilong; Ito, Yoshiaki; Osato, Motomi
Article

Development of Multilineage Adult Hematopoiesis in the Zebrafish with a Runx1 Truncation Mutation

Blood, v. 115, (14), 2010, APR 8, p. 2806-2809
Sood, Raman; English, Milton A.; Belele, Christiane L.; Jin, Hao; Bishop, Kevin; Haskins, Rebecca; McKinney, Mary Cathleen; Chahal, Jagman; Weinstein, Brant M.; Wen, Zilong; Liu, P. Paul
Article

Regulation of Gene Expression by FSP27 in White and Brown Adipose Tissue

BMC Genomics, v. 11, (1), 2010, JUL 22, Article number 446
Li, De; Zhang, Yinxin; Xu, Li; Zhou, Linkang; Wang, Yue; Xue, Bofu; Wen, Zilong; Li, Peng; Sang, Jianli
Article

2009 2

Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor

Molecular Cell, v. 33, (6), 2009, MAR 27, p. 692-703
Wang, Rui; Wei, Zhiyi; Jin, Hao; Wu, Hao; Yu, Cong; Wen, Wenyu; Chan, Ling Nga; Wen, Zilong; Zhang, Mingjie
Article

Definitive Hematopoietic Stem/progenitor Cells Manifest Distinct Differentiation Output in the Zebrafish VDA and PBI

Development, v. 136, (4), 2009, FEB 15, p. 647-654
Jin, Hao; Sood, Raman; Xu, Jin; Zhen, Fenghua; English, Milton A.; Liu, Pu Paul; Wen, Zilong
Article

2008 2

Mypt1-mediated Spatial Positioning of Bmp2-producing Cells is Essential for Liver Organogenesis

Development, v. 135, (19), 2008, p. 3209-3218
Huang, Honghui; Ruan, Hua; Aw, Meng Yuan; Hussain, Alamgir; Guo, Lin; Gao, Chuan; Qian, Feng; Leung, Thomas; Song, Haiwei; Kimelman, David; Wen, Zilong; Peng, Jinrong
Article

Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

PloS One, v. 3, (8), 2008, AUG 6
Toh, Shen Yon; Gong, Jingyi; Du, Guoli; Li, John Zhong; Yang, Shuqun; Ye, Jing; Yao, Huilan; Zhang, Yinxin; Xue, Bofu; Li, Qing; Yang, Hongyuan; Wen, Zilong; Li, Peng
Article

2007 5

Amotl2 is Essential for Cell Movements in Zebrafish Embryo and Regulates C-Src Translocation

Development, v. 134, (5), March 2007, p. 979-988
Huang, Huizhe; Lu, Fu-I; Jia, Shunji; Meng, Shu; Cao, Ying; Wang, Yeqi; Ma, Weiping; Yin, Kun; Wen, Zilong; Peng, Jingrong; Thisse, Christine; Thisse, Bernard; Meng, Anming
Article

Cideb Regulates Diet-induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation

Diabetes, v. 56, (10), 2007, OCT, p. 2523-2532
Li, John Zhong; Ye, Jing; Xue, Bofu; Qi, Jingzhong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong; Li, Peng
Article

Distinct Functions for Different Scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis

PLoS Biology, v. 5, (5), May 2007, p. 1110-1119
Qian, Feng; Zhen, Fenghua; Xu, Jin; Huang, Mei; Li, Wanyu; Wen, Zilong
Article

Migratory Path of Definitive Hematopoietic Stem/progenitor Cells During Zebrafish Development

Blood, v. 109, (12), 2007, p. 5208-5214
Jin, Hao; Xu, Jin; Wen, Zilong
Article

The Zebrafish Udu Gene Encodes a Novel Nuclear Factor and is Essential for Primitive Erythroid Cell Development

Blood, v. 110, (1), 1 July 2007, p. 99-106
Liu, Yanmei; Du, Linsen; Osato, Motomi; Teo, Eng Hui; Qian, Feng; Jin, Hao; Zhen, Fenghua; Xu, Jin; Guo, Lin; Huang, Honghui; Chen, J.; Geisler, Robert; Jiang, Yun-Jin; Peng, Jinrong; Wen, Zilong
Article

2006 1

The 5′ zebrafish scl promoter targets transcription to the brain, spinal cord, and hematopoietic and endothelial progenitors

Developmental Dynamics, v. 235, (1), January 2006, p. 60-67
Jin, Hao; Xu, Jin; Qian, Feng; Du, Linsen; Tan, Chee Yong; Lin, Zhixin; Peng, Jinrong; Wen, Zilong
Article

2005 4

Genome-wide identification of female-enriched genes in zebrafish

Developmental Dynamics, v. 232, (1), January 2005, p. 171-179
Wen, Chaoming; Zhang, Zhenhai; Ma, Weiping; Xu, Min; Wen, Zilong; Peng, Jinrong
Article

Identification of the Conserved Serine/threonine Residues Important for Gibberellin-sensitivity of Arabidopsis RGL2 Protein

Plant Journal, v. 44, (1), October 2005, p. 88-99
Hussain, Alamgir; Cao, Dongni; Cheng, Hui; Wen, Zilong; Peng, Jinrong
Article

Loss of Function of Def Selectively Up-regulates Δ113p53 Expression to Arrest Expansion Growth of Digestive Organs in Zebrafish

Genes and Development, v. 19, (23), 1 December 2005, p. 2900-2911
Chen, Jun; Ruan, Hua; Ng, Sok Meng; Gao, Chuan; Soo, Hui Meng; Wu, Wei; Zhang, Zhenhai; Wen, Zilong; Lane, David P.; Peng, Jinrong
Article

Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes

Developmental Dynamics, v. 233, (3), July 2005, p. 1163-1172
Qian, Feng; Zhen, Fenghua; Ong, Chinthing; Jin, Suk-Won; Soo, Hui Meng; Stainier, Didier Y.R.; Lin, Shuo; Peng, Jinrong; Wen, Zilong
Article

2003 2

15000 Unique Zebrafish EST Clusters and Their Future Use in Microarray for Profiling Gene Expression Patterns During Embryogenesis

Genome Research, v. 13, (3), 2003, p. 455-466
Lo, Jane; Lee, Sorcheng; Xu, Min; Liu, Feng; Ruan, Hua; Eun, Alvin; He, Yawen; Ma, Weiping; Wang, Weefuen; Wen, Zilong; Peng, Jinrong
Article

Emergence of a coronavirus infectious bronchitis virus mutant with a truncated 3b gene: Functional characterization of the 3b protein in pathogenesis and replication

Virology, v. 311, (1), 20 June 2003, p. 16-27
Shen, Shuo; Wen, Zilong; Liu, Dingxiang
Article

2002 3

Cloning and Expression Pattern of the lysozyme C Gene in Zebrafish

Mechanisms of Development, v. 113, (1), 2002, p. 69-72
Liu, Feng; Wen, Zilong
Article

Morphologic transformation of the thymus in developing zebrafish

Developmental Dynamics, v. 225, (1), September 2002, p. 87-94
Lam, Siewhong; Chua, H. L.; Gong, Zhiyuan; Wen, Zilong; LAM, Toongjin; SIN, Yokemin
Article

The chromatin-remodelling factor BRG1 selectively activates a subset of interferon α-inducible genes

Nature Cell BIiology, v. 4, (10), Oct 2002, p. 774-781
Huang, Mei; Qian, Feng; Hu, Yuanyu; Ang, Chengeng; Li, Zhong; Wen, Zilong
Article

1999 1

The Linker Domain of Stat1 is Required for Gamma Interferon-driven Transcription

Molecular and Cellular Biology, v. 19, (7), 1999, p. 5016-5112
Yang, Edward; Wen, Zilong; Haspel, Richard L.; Zhang, Jue J.; Darnell, James E.
Article

1997 3

Mapping of Stat3 Serine Phosphorylation to a Single Residue (727) and Evidence that Serine Phosphorylation has no Influence on DNA Binding of Stat1 and Stat3

Nucleic Acids Research, v. 25, (11), 1997, p. 2062-2067
Wen, Zilong; Darnell, James E.
Article

STAT signaling is active during early mammalian development

Developmental Dynamics, v. 208, (2), 1997, February, p. 190-198
Duncan, Stephen A.; Zhong, Zhong; Wen, Zilong; Darnell, James E.
Article

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

Molecular and Cellular Biology, v. 17, (11), 1997, November, p. 6618-6623
Wen, Zilong; Xu, Liangzhong; Darnell, James E.; Zhu, Xuejun
Article

1996 1

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon γ

Proceedings of the National Academy of Sciences of the United States of America, v. 93, (15), 1996, July, p. 7673-7678
Bromberg, Jacqueline F.; Horvath, Curt M.; Wen, Zilong; Schreiber, Robert D.; Darnell, James E.
Article

1995 6

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

Genes and Development, v. 9, (8), 1995, p. 984-994
Horvath, Curt M.; Wen, Zilong; Darnell, James E.
Article

Distribution of the mammalian Stat gene family in mouse chromosomes

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Epidermal Growth Factor and Lipopolysaccharide Activate Stat3 Transcription Factor in Mouse Liver

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Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition

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Interaction of an α-melanocyte-stimulating hormone-diphtheria toxin fusion protein with melanotropin receptors in human melanoma metastases

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Phe496 and Leu497 are Essential for Receptor Binding and Cytotoxic Action of Murine Interleukin-4 Receptor Targeted Fusion Toxin DAB389-mIL-4

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Diphtheria toxin-related α-melanocyte-stimulating hormone Fusion Toxin: Internal in-frame Deletion from Thr387 to His485 Results in the Formation of a Highly Potent Fusion Toxin which is Resistant to Proteolytic Degradation

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Cellular Processing of the Interleukin-2 Fusion Toxin DAB486-IL-2 and Efficient Delivery of Diphtheria Fragment A to the Cytosol of Target Cells Requires Arg194

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Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia

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Cross-organ single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish

Cell Reports, v. 42, (7), July 2023, article number 112793
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Metaphocytes are IL-22BP-producing cells regulated by ETS transcription factor Spic and essential for zebrafish barrier immunity

Cell Reports, v. 42, (5), May 2023, article number 112483
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Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

eLife, May 2023, article number eLife.87434.1
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Csf1rb regulates definitive hematopoiesis in zebrafish

Development, v. 149, (16), August 2022, article number dev200534
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Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage

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Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression

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The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish

Development, v. 149, (19), October 2022, article number dev200881
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De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation

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Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish

Science China Life Sciences, 16 March 2021
Chen, Jiakui; Li, Gaofei; Lian, Junwei; Ma, Ning; Huang, Zhibin; Li, Jianchao; Wen, Zilong; Zhang, Wenqing; Zhang, Yiyue

The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway

Cell Death & Disease, v. 12, (10), October 2021, article number 906
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Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity

Cell Reports, v. 33, (1), 6 October 2020, article number 108227
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In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy

eLife, v. 9, January 2020, article number e52024
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Lightening the Way of Hematopoiesis: Infrared Laser-Mediated Lineage Tracing With High Spatial-Temporal Resolution

Experimental Hematology, v. 85, May 2020, p. 3-7
He, Sicong; Xu, Jin; Qu, Jianan; Wen, Zilong

Tripartite-Motif Family Protein 35-28 Regulates Microglia Development by Preventing Necrotic Death of Microglial Precursors in Zebrafish

The Journal of Biological Chemistry, v. 295, (26), June 2020, p. 8846-8856
Yu, Tao; Kuang, Haoyue; Chen, Jiahao; Lin, Xi; Wu, Yi; Chen, Keyu; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong

Two phenotypically and functionally distinct microglial populations in adult zebrafish

Science Advances, v. 6, (47), November 2020, article number eabd1160
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Article 4

An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis

Developmental Cell, v. 49, (4), May 2019, p. 605-617.e5
Lin, Xi; Zhou, Qiuxia; Lin, Guanzhen; Xu, Jin; Wen, Zilong

Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish

iScience, v. 13, March 2019, p. 391-401
Jin, Wan; Dai, Yimei; Li, Funing; Zhu, Lu; Huang, Zhibin; Liu, Wei; Li, Jianchao; Zhang, Mingjie; Du, Jiulin; Zhang, Wenqing; Wen, Zilong

Nlrc3-like is required for microglia maintenance in zebrafish

Journal of Genetics and Genomics, v. 46, (6), June 2019, p. 291-299
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Tissue-resident macrophages: from zebrafish to mouse

Blood Science, v. 1, (1), August 2019, p. 57-60
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Article 2

Adult Zebrafish Langerhans Cells Arise from Hematopoietic Stem/Progenitor Cells

eLIFE, v. 7, June 2018, article number e36131
He, Sicong; Chen, Jiahao; Jiang, Yunyun; Wu, Yi; Zhu, Lu; Jin, Wan; Zhao, Changlong; Yu, Tao; Wang, Tienan; Wu, Shuting; Lin, Xi; Qu, Jianan; Zhang, Wenqing; Wen, Zilong; Xu, Jin

Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial Precursors

Developmental Cell, v. 46, (5), September 2018, p. 552-563.e4
Wu, Shuting; Xue, Rongtao; Hassan, Shaoli; Nguyen, Thi My Linh; Wang, Tienan; Pan, Hongru; Xu, Jin; Liu, Qifa; Zhang, Wenqing; Wen, Zilong

Conference paper 1

Labeling single cell for in-vivo study of cell fate mapping and lineage tracing

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 10497, 2018, article number 104970J
He, Sicong; Xu, Jin; Wu yi; Tian, Ye; Sun, Qiqi; Wen, Zilong; Qu, Jianan

Article 3

C-Myb Hyperactivity Leads to Myeloid and Lymphoid Malignancies in Zebrafish

Leukemia, v. 31, (1), January 2017, p. 222-233
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Distinct Regulatory Networks Control the Development of Macrophages of Different Origins in Zebrafish

Blood, v. 129, (4), January 2017, p. 509-519
Yu, Tao; Guo, Weilin; Tian, Ye; Xu, Jin; Chen, Jiahao; Li, Li; Wen, Zilong

The First Wave of T Lymphopoiesis in Zebrafish Arises from Aorta Endothelium Independent of Hematopoietic Stem Cells

Journal of Experimental Medicine, v. 214, (11), November 2017, p. 3347-3360
Tian, Ye; Xu, Jin; Feng, Shachuan; He, Sicong; Zhao, Shizheng; Zhu, Lu; Jin, Wan; Dai, Yimei; Luo, Lingfei; Qu, Jianan Y.; Wen, Zilong

Conference paper 1

NME7 Functions in ciliogenesis and left-right asymmetry development

Liu, Pengfei; Yu, Tao; Wen, Zilong; Qi, Robert Zhong

Article 5

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish

Journal of Genetics and Genomics, v. 43, (10), October 2016, p. 593-600
Dai, Yimei; Zhu, Lu; Huang, Zhibin; Zhou, Minyu; Jin, Wan; Liu, Wei; Xu, Mengchang; Yu, Tao; Zhang, Yiyue; Wen, Zilong; Liao, Wangjun; Zhang, Wenqing

c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish

Blood, v. 128, (3), July 2016, p. 415-426
Jin, Hao; Huang, Zhibin; Chi, Yali; Wu, Mei; Zhou, Riyang; Zhao, Lingfeng; Xu, Jin; Zhen, Fenghua; Lan, Yahui; Li, Li; Zhang, Wenqing; Wen, Zilong; Zhang, Yiyue

Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine

Developmental Cell, v. 38, (2), July 2016, p. 214-222
Xu, Jin; Wang, Tienan; Wu, Yi; Jin, Wan; Wen, Zilong

Real-Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria-Targeting AIE Fluorogen

Advanced Functional Materials, v. 26, (39), October 2016, p. 7132-7138
Situ, Bo; Chen, Sijie; Zhao, Engui; Leung, Wai Tung; Chen, Yilong; Hong, Yuning; Lam, Wing Yip; Wen, Zilong; Liu, Wei; Zhang, Wenqing; Zheng, Lei; Tang, Benzhong

RNA Polymerase III Component Rpc9 Regulates Hematopoietic Stem and Progenitor Cell Maintenance in Zebrafish

Development (Cambridge), v. 143, (12), June 2016, p. 2103-2110
Wei, Yonglong; Xu, Jin; Zhang, Wenqing; Wen, Zilong; Liu, Feng

Conference paper 1

Origin of Microglia in Brain: A Study in Zebrafish Model

Biomedical Optics Congress 2016 / Optica Publishing Group. Florida United States : Optica Publishing Group, 2016, Paper BTh2D.3
He, Sicong; Xu, Jin; Wen, Zilong; Qu, Jianan

Article 3

Functions of Idh1 and Its Mutation in the Regulation of Developmental Hematopoiesis in Zebrafish

Blood, v. 125, (19), May 2015, p. 2974-2984
Shi, Xiangguo; He, Bai-Liang; Ma, Alvin C.H.; Guo, Yuhan; Chi, Yali; Man, Cheuk Him; Zhang, Wenqing; Zhang, Yiyue; Wen, Zilong; Cheng, Tao; Leung, Anskar Y.H.

Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish

Scientific Reports, v. 5, March 2015, article number 9011
Yuan, Hao; Zhang, Tao; Liu, Xiaohui; Deng, Min; Zhang, Wenqing; Wen, Zilong; Chen, Saijuan; Chen, Zhu; De The, Hugues; Zhou, Jun; Zhu, Jun

Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

Developmental Cell, v. 34, (6), September 2015, p. 632-641
Xu, Jin; Zhu, Lu; He, Sicong; Wu, Yi; Jin, Wan; Yu, Tao; Qu, Jianan Y.; Wen, Zilong

Article 3

IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and basal random motility in a zebrafish injury-induced inflammation model

Journal of Immunology, v. 192, (12), June 2014, p. 5998-6008
Yan, Bo; Han, Peidong; Pan, Lifeng; Lu, Wei; Xiong, Jingwei; Zhang, Mingjie; Zhang, Wenqing; Li, Li; Wen, Zilong

In Vivo Micro-Vascular Imaging and Flow Cytometry in Zebrafish Using Two-photon Excited Endogenous Fluorescence

Biomedical Optics Express, v. 5, (3), 2014, p. 653-663
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan

In Vivo Nonlinear Optical Imaging of Immune Responses: Tissue Injury and Infection

Biophysical Journal, v. 107, (10), 2014, p. 2436-2443
Zeng, Yan; Yan, Bo; Xu, Jin; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan

Conference paper 1

Nonlinear optical microscopy for in vivo imaging microvasculature and blood flow

Conference Proceedings: Biomedical Optics, 2014, article number BM4A.2
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan

Article 3

Hemogenic Endothelium Specification and Hematopoietic Stem Cell Maintenance Employ Distinct Scl Isoforms

Development (Cambridge), v. 140, (19), October 2013, p. 3977-3985
Zhen, Fenghua; Lan, Yahui; Yan, Bo; Zhang, Wenqing; Wen, Zilong

Label-Free in Vivo Imaging of Human Leukocytes Using Two-photon Excited Endogenous Fluorescence

Journal of Biomedical Optics, v. 18, (4), 2013, article number 040504
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan

Suppression of Pu.1 Function Results in Expanded Myelopoiesis in Zebrafish

Leukemia, v. 27, (9), September 2013, p. 1913-1917
Sun, Jiping; Liu, Wei; Li, Li; Chen, Jiahao; Wu, Mei; Zhang, Yiyue; Leung, Anskar; Zhang, Wenqing; Wen, Zilong; Liao, Wangjun

Conference paper 1

Two-Photon Excited Endogenous Fluorescence for Label-Free in Vivo Imaging Ingestion of Disease-Causing Bacteria by Human Leukocytes

SPIE Proceedings, v. 8588, February 2013
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan

Article 7

Antiparallel Coiled-coil-mediated Dimerization of Myosin X

Proceedings of the National Academy of Sciences of the United States of America, v. 109, (43), 2012, Oct, p. 17388-17393
Lu, Qing; Ye, Fei; Wei, Zhiyi; Wen, Zilong; Zhang, Mingjie

Label-free in Vivo Flow Cytometry in Zebrafish Using Two-photon Autofluorescence Imaging

Optics Letters, v. 37, (13), 2012, Jul, p. 2490-2492
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan

Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration

Journal of Biological Chemistry, v. 287, (30), 2012, Jul, p. 25353-25360
Li, Li; Yan, Bo; Shi, Yu-Qian; Zhang, Wen-Qing; Wen, Zi-Long

Myelopoiesis during Zebrafish Early Development

Journal of Genetics and Genomics, v. 39, (9), 2012, Sep, p. 435-442
Xu, Jin; Du, Linsen; Wen, Zilong

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

Developmental cell, v. 23, (6), December 2012, p. 1189-1202
Li, Ying; Du, Xu-fei; Liu, Chang-sheng; Wen, Zi-long; Du, Jiu-lin

Runx1 Regulates Embryonic Myeloid Fate Choice in Zebrafish Through a Negative Feedback Loop Inhibiting Pu.1 Expression

Blood, v. 119, (22), 2012, Jun, p. 5239-5249
Jin, Hao; Li, Li; Xu, Jin; Zhen, Fenghua; Zhu, Lu; Liu, Pu Paul; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong

SUMO1-activating Enzyme Subunit 1 Is Essential for the Survival of Hematopoietic Stem/Progenitor Cells in Zebrafish

Development (Cambridge), v. 139, (23), 2012, Dec, p. 4321-4329
Li, Xiuling; Lan, Yahui; Xu, Jin; Zhang, Wenqing; Wen, Zilong

Conference paper 1

In vivo cytometry using two-photon autofluorescence microscopy

Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America), Miami, Florida, United States, 28 Apr - 2 May, 2012
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan

Article 4

CMyb Regulates Hematopoietic Stem/Progenitor Cell Mobilization during Zebrafish Hematopoiesis

Blood, v. 118, (15), 2011, Oct, p. 4093-4101
Zhang, Yiyue; Jin, H.; Li, L.; Qin, F.X.F.; Wen, Z.

Erythrocytes in the trunk of zebrafish embryos

Development, v. 138, (18), September 2011, p. 3862-3863
Jin, Hao; Wen, Zilong

Irf8 Regulates Macrophage Versus Neutrophil Fate During Zebrafish Primitive Myelopoiesis

Blood, v. 117, (4), 2011, p. 1359-1369
Li, Li; Jin, Hao; Xu, Jin; Shi, Yuqian; Wen, Zilong

Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis

Development, v. 138, (4), 2011, Jan, p. 619-629
Du, Linsen; Xu, J.; Li, Xiuling; Ma, Ning; Liu, Yanmei; Peng, Jinrong; Osato, Motomi; Zhang, Wenqing; Wen, Zilong

Article 3

A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells

Stem Cells, v. 28, (10), 2010, p. 1869-1881
Ng, Cherry Ee Lin; Yokomizo, Tomomasa; Yamashita, Namiko; Cirovic, Branko; Jin, Hao; Wen, Zilong; Ito, Yoshiaki; Osato, Motomi

Development of Multilineage Adult Hematopoiesis in the Zebrafish with a Runx1 Truncation Mutation

Blood, v. 115, (14), 2010, APR 8, p. 2806-2809
Sood, Raman; English, Milton A.; Belele, Christiane L.; Jin, Hao; Bishop, Kevin; Haskins, Rebecca; McKinney, Mary Cathleen; Chahal, Jagman; Weinstein, Brant M.; Wen, Zilong; Liu, P. Paul

Regulation of Gene Expression by FSP27 in White and Brown Adipose Tissue

BMC Genomics, v. 11, (1), 2010, JUL 22, Article number 446
Li, De; Zhang, Yinxin; Xu, Li; Zhou, Linkang; Wang, Yue; Xue, Bofu; Wen, Zilong; Li, Peng; Sang, Jianli

Article 2

Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor

Molecular Cell, v. 33, (6), 2009, MAR 27, p. 692-703
Wang, Rui; Wei, Zhiyi; Jin, Hao; Wu, Hao; Yu, Cong; Wen, Wenyu; Chan, Ling Nga; Wen, Zilong; Zhang, Mingjie

Definitive Hematopoietic Stem/progenitor Cells Manifest Distinct Differentiation Output in the Zebrafish VDA and PBI

Development, v. 136, (4), 2009, FEB 15, p. 647-654
Jin, Hao; Sood, Raman; Xu, Jin; Zhen, Fenghua; English, Milton A.; Liu, Pu Paul; Wen, Zilong

Article 2

Mypt1-mediated Spatial Positioning of Bmp2-producing Cells is Essential for Liver Organogenesis

Development, v. 135, (19), 2008, p. 3209-3218
Huang, Honghui; Ruan, Hua; Aw, Meng Yuan; Hussain, Alamgir; Guo, Lin; Gao, Chuan; Qian, Feng; Leung, Thomas; Song, Haiwei; Kimelman, David; Wen, Zilong; Peng, Jinrong

Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

PloS One, v. 3, (8), 2008, AUG 6
Toh, Shen Yon; Gong, Jingyi; Du, Guoli; Li, John Zhong; Yang, Shuqun; Ye, Jing; Yao, Huilan; Zhang, Yinxin; Xue, Bofu; Li, Qing; Yang, Hongyuan; Wen, Zilong; Li, Peng

Article 5

Amotl2 is Essential for Cell Movements in Zebrafish Embryo and Regulates C-Src Translocation

Development, v. 134, (5), March 2007, p. 979-988
Huang, Huizhe; Lu, Fu-I; Jia, Shunji; Meng, Shu; Cao, Ying; Wang, Yeqi; Ma, Weiping; Yin, Kun; Wen, Zilong; Peng, Jingrong; Thisse, Christine; Thisse, Bernard; Meng, Anming

Cideb Regulates Diet-induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation

Diabetes, v. 56, (10), 2007, OCT, p. 2523-2532
Li, John Zhong; Ye, Jing; Xue, Bofu; Qi, Jingzhong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong; Li, Peng

Distinct Functions for Different Scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis

PLoS Biology, v. 5, (5), May 2007, p. 1110-1119
Qian, Feng; Zhen, Fenghua; Xu, Jin; Huang, Mei; Li, Wanyu; Wen, Zilong

Migratory Path of Definitive Hematopoietic Stem/progenitor Cells During Zebrafish Development

Blood, v. 109, (12), 2007, p. 5208-5214
Jin, Hao; Xu, Jin; Wen, Zilong

The Zebrafish Udu Gene Encodes a Novel Nuclear Factor and is Essential for Primitive Erythroid Cell Development

Blood, v. 110, (1), 1 July 2007, p. 99-106
Liu, Yanmei; Du, Linsen; Osato, Motomi; Teo, Eng Hui; Qian, Feng; Jin, Hao; Zhen, Fenghua; Xu, Jin; Guo, Lin; Huang, Honghui; Chen, J.; Geisler, Robert; Jiang, Yun-Jin; Peng, Jinrong; Wen, Zilong

Article 1

The 5′ zebrafish scl promoter targets transcription to the brain, spinal cord, and hematopoietic and endothelial progenitors

Developmental Dynamics, v. 235, (1), January 2006, p. 60-67
Jin, Hao; Xu, Jin; Qian, Feng; Du, Linsen; Tan, Chee Yong; Lin, Zhixin; Peng, Jinrong; Wen, Zilong

Article 4

Genome-wide identification of female-enriched genes in zebrafish

Developmental Dynamics, v. 232, (1), January 2005, p. 171-179
Wen, Chaoming; Zhang, Zhenhai; Ma, Weiping; Xu, Min; Wen, Zilong; Peng, Jinrong

Identification of the Conserved Serine/threonine Residues Important for Gibberellin-sensitivity of Arabidopsis RGL2 Protein

Plant Journal, v. 44, (1), October 2005, p. 88-99
Hussain, Alamgir; Cao, Dongni; Cheng, Hui; Wen, Zilong; Peng, Jinrong

Loss of Function of Def Selectively Up-regulates Δ113p53 Expression to Arrest Expansion Growth of Digestive Organs in Zebrafish

Genes and Development, v. 19, (23), 1 December 2005, p. 2900-2911
Chen, Jun; Ruan, Hua; Ng, Sok Meng; Gao, Chuan; Soo, Hui Meng; Wu, Wei; Zhang, Zhenhai; Wen, Zilong; Lane, David P.; Peng, Jinrong

Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes

Developmental Dynamics, v. 233, (3), July 2005, p. 1163-1172
Qian, Feng; Zhen, Fenghua; Ong, Chinthing; Jin, Suk-Won; Soo, Hui Meng; Stainier, Didier Y.R.; Lin, Shuo; Peng, Jinrong; Wen, Zilong

Article 2

15000 Unique Zebrafish EST Clusters and Their Future Use in Microarray for Profiling Gene Expression Patterns During Embryogenesis

Genome Research, v. 13, (3), 2003, p. 455-466
Lo, Jane; Lee, Sorcheng; Xu, Min; Liu, Feng; Ruan, Hua; Eun, Alvin; He, Yawen; Ma, Weiping; Wang, Weefuen; Wen, Zilong; Peng, Jinrong

Emergence of a coronavirus infectious bronchitis virus mutant with a truncated 3b gene: Functional characterization of the 3b protein in pathogenesis and replication

Virology, v. 311, (1), 20 June 2003, p. 16-27
Shen, Shuo; Wen, Zilong; Liu, Dingxiang

Article 3

Cloning and Expression Pattern of the lysozyme C Gene in Zebrafish

Mechanisms of Development, v. 113, (1), 2002, p. 69-72
Liu, Feng; Wen, Zilong

Morphologic transformation of the thymus in developing zebrafish

Developmental Dynamics, v. 225, (1), September 2002, p. 87-94
Lam, Siewhong; Chua, H. L.; Gong, Zhiyuan; Wen, Zilong; LAM, Toongjin; SIN, Yokemin

The chromatin-remodelling factor BRG1 selectively activates a subset of interferon α-inducible genes

Nature Cell BIiology, v. 4, (10), Oct 2002, p. 774-781
Huang, Mei; Qian, Feng; Hu, Yuanyu; Ang, Chengeng; Li, Zhong; Wen, Zilong

Article 1

The Linker Domain of Stat1 is Required for Gamma Interferon-driven Transcription

Molecular and Cellular Biology, v. 19, (7), 1999, p. 5016-5112
Yang, Edward; Wen, Zilong; Haspel, Richard L.; Zhang, Jue J.; Darnell, James E.

Article 3

Mapping of Stat3 Serine Phosphorylation to a Single Residue (727) and Evidence that Serine Phosphorylation has no Influence on DNA Binding of Stat1 and Stat3

Nucleic Acids Research, v. 25, (11), 1997, p. 2062-2067
Wen, Zilong; Darnell, James E.

STAT signaling is active during early mammalian development

Developmental Dynamics, v. 208, (2), 1997, February, p. 190-198
Duncan, Stephen A.; Zhong, Zhong; Wen, Zilong; Darnell, James E.

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

Molecular and Cellular Biology, v. 17, (11), 1997, November, p. 6618-6623
Wen, Zilong; Xu, Liangzhong; Darnell, James E.; Zhu, Xuejun

Article 1

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon γ

Proceedings of the National Academy of Sciences of the United States of America, v. 93, (15), 1996, July, p. 7673-7678
Bromberg, Jacqueline F.; Horvath, Curt M.; Wen, Zilong; Schreiber, Robert D.; Darnell, James E.

Article 6

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

Genes and Development, v. 9, (8), 1995, p. 984-994
Horvath, Curt M.; Wen, Zilong; Darnell, James E.

Distribution of the mammalian Stat gene family in mouse chromosomes

Genomics, v. 29, (1), 1995, p. 225-228
Zhong, Zhong; Wen, Zilong; Darnell, James E.; Mui, Alice; Miyajima, Atsushi; Gilbert, Debra J.; Schindler, Christian W.; Quelle, Frederick W.; Ihle, James N.; Jenkins, Nancy A B G; Copeland, Neal G L F

In Vivo Growth Hormone Treatment Rapidly Stimulates the Tyrosine Phosphorylation and Activation of Stat3

Molecular Endocrinology, v. 9, (2), 1995, p.171-177
Gronowski, Ann M.; Zhong, Zhong; Wen, Zilong; Thomas, Michael J.; Rotwein, Peter S.; Darnell, James E.

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phopshorylation

Cell, v. 82, (2), 1995, July, p. 241-250
Wen, Zilong; Zhong, Zhong; Darnell, James E.

Stat3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase

Proceedings of the National Academy of Sciences of the United States of America, v. 92, (15), 1995, July, p. 6915-6919
Boulton, Teri G.; Zhong, Zhong; Wen, Zilong; Darnell, James E.; Stahl, Neil; Yancopouloš, George D.

The Genomic Structure of the STAT Genes-multiple Exons in Coincident Sites in STAT1 and STAT2

Nucleic Acids Research, v. 23, (3), 1995, February, p. 459-463
Qureshi, Sajjad A.; Yan, Riqiang; Zhong, Zhong; Wen, Zilong; Darnell, James E.

Article 3

Epidermal Growth Factor and Lipopolysaccharide Activate Stat3 Transcription Factor in Mouse Liver

Journal of Biological Chemistry, v. 269, (35), 1994, Septermber, p. 21933-21935
Ruff-Jamison, Susan; Zhong, Zhong; Wen, Zilong; Chen, Katherine; Darnell, James E.; Cohen, Stanley W.

Stat3 and Stat4: members of the family of signal transducers and activators of transcription

Proceedings of the National Academy of Sciences of the United States of America, v. 91, (11), 1994, May, p. 4806-4810
Zhong, Zhong; Wen, Zilong; Darnell, James E.

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

Science, v, 264, (5155), 1994, p. 95-98
Wen, Zilong; Zhong, Zhong; Darnell, James E.

Article 1

Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition

Immunology, v. 151, (10) 15 November 1993, p. 5387-5397
Solheim, Joyce C.; Carreño, Beatriz M.; Smith, Joseph D.; Gorka, John; Myers, Nancy B.; Wen, Zilong; Martinko, John M.; Lee, David R.; Hansen, Ted H.

Article 2

Interaction of an α-melanocyte-stimulating hormone-diphtheria toxin fusion protein with melanotropin receptors in human melanoma metastases

Cancer Research, v. 52, (9), 1992, p. 2545-2548
Tatro,Jeffrey B.; Wen, Zilong; Entwistle, Margaret L.; Atkin, Michael B.; Smith, Thomas J.; Reichlin, Seymour; Murphy, John R.

Phe496 and Leu497 are Essential for Receptor Binding and Cytotoxic Action of Murine Interleukin-4 Receptor Targeted Fusion Toxin DAB389-mIL-4

Protein Engineering, Design and Selecition\tv. 5, (3), 1992, p. 241-248
Lakkis, Fadi G.; Landgraf, Bryan E.; Wen, Zilong; Strom, Terry B.; Murphy, John R.

Article 1

Diphtheria toxin-related α-melanocyte-stimulating hormone Fusion Toxin: Internal in-frame Deletion from Thr387 to His485 Results in the Formation of a Highly Potent Fusion Toxin which is Resistant to Proteolytic Degradation

Journal of Biological Chemistry, v. 266, (19), 1991, p. 12289-12293
Wen, Zilong; Tao, Xu; Lakkis, Fadi G.; Kiyokawa, Tetsuyuki; Murphy, John R.

Article 1

Cellular Processing of the Interleukin-2 Fusion Toxin DAB486-IL-2 and Efficient Delivery of Diphtheria Fragment A to the Cytosol of Target Cells Requires Arg194

Journal of Biological Chemistry, v. 265, (33), 1990, p. 20673-20677
Williams, Diane P.; Wen, Zilong; Watson, Rose Scott; Boyd, Jessica M.; Strom, Terry B.; Murphy, John R.

2017 4

C-Myb Hyperactivity Leads to Myeloid and Lymphoid Malignancies in Zebrafish

Leukemia, v. 31, (1), January 2017, p. 222-233
Liu, Wei; Wu, M.; Huang, Z.; Lian, J.; Chen, J.; Wang, Tienan; Leung, A.Y.H.; Liao, Y.; Zhang, Zhang Jin; Liu, Qifa; Yen, K.; Lin, S.; Zon, Leonard I.; Wen, Zilong; Zhang, Yunfan; Zhang, Wenqing
Article

Distinct Regulatory Networks Control the Development of Macrophages of Different Origins in Zebrafish

Blood, v. 129, (4), January 2017, p. 509-519
Yu, Tao; Guo, Weilin; Tian, Ye; Xu, Jin; Chen, Jiahao; Li, Li; Wen, Zilong
Article

The First Wave of T Lymphopoiesis in Zebrafish Arises from Aorta Endothelium Independent of Hematopoietic Stem Cells

Journal of Experimental Medicine, v. 214, (11), November 2017, p. 3347-3360
Tian, Ye; Xu, Jin; Feng, Shachuan; He, Sicong; Zhao, Shizheng; Zhu, Lu; Jin, Wan; Dai, Yimei; Luo, Lingfei; Qu, Jianan Y.; Wen, Zilong
Article

NME7 Functions in ciliogenesis and left-right asymmetry development

Liu, Pengfei; Yu, Tao; Wen, Zilong; Qi, Robert Zhong
Conference paper

2016 6

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish

Journal of Genetics and Genomics, v. 43, (10), October 2016, p. 593-600
Dai, Yimei; Zhu, Lu; Huang, Zhibin; Zhou, Minyu; Jin, Wan; Liu, Wei; Xu, Mengchang; Yu, Tao; Zhang, Yiyue; Wen, Zilong; Liao, Wangjun; Zhang, Wenqing
Article

c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish

Blood, v. 128, (3), July 2016, p. 415-426
Jin, Hao; Huang, Zhibin; Chi, Yali; Wu, Mei; Zhou, Riyang; Zhao, Lingfeng; Xu, Jin; Zhen, Fenghua; Lan, Yahui; Li, Li; Zhang, Wenqing; Wen, Zilong; Zhang, Yiyue
Article

Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine

Developmental Cell, v. 38, (2), July 2016, p. 214-222
Xu, Jin; Wang, Tienan; Wu, Yi; Jin, Wan; Wen, Zilong
Article

Real-Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria-Targeting AIE Fluorogen

Advanced Functional Materials, v. 26, (39), October 2016, p. 7132-7138
Situ, Bo; Chen, Sijie; Zhao, Engui; Leung, Wai Tung; Chen, Yilong; Hong, Yuning; Lam, Wing Yip; Wen, Zilong; Liu, Wei; Zhang, Wenqing; Zheng, Lei; Tang, Benzhong
Article

RNA Polymerase III Component Rpc9 Regulates Hematopoietic Stem and Progenitor Cell Maintenance in Zebrafish

Development (Cambridge), v. 143, (12), June 2016, p. 2103-2110
Wei, Yonglong; Xu, Jin; Zhang, Wenqing; Wen, Zilong; Liu, Feng
Article

Origin of Microglia in Brain: A Study in Zebrafish Model

Biomedical Optics Congress 2016 / Optica Publishing Group. Florida United States : Optica Publishing Group, 2016, Paper BTh2D.3
He, Sicong; Xu, Jin; Wen, Zilong; Qu, Jianan
Conference paper

2015 3

Functions of Idh1 and Its Mutation in the Regulation of Developmental Hematopoiesis in Zebrafish

Blood, v. 125, (19), May 2015, p. 2974-2984
Shi, Xiangguo; He, Bai-Liang; Ma, Alvin C.H.; Guo, Yuhan; Chi, Yali; Man, Cheuk Him; Zhang, Wenqing; Zhang, Yiyue; Wen, Zilong; Cheng, Tao; Leung, Anskar Y.H.
Article

Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish

Scientific Reports, v. 5, March 2015, article number 9011
Yuan, Hao; Zhang, Tao; Liu, Xiaohui; Deng, Min; Zhang, Wenqing; Wen, Zilong; Chen, Saijuan; Chen, Zhu; De The, Hugues; Zhou, Jun; Zhu, Jun
Article

Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

Developmental Cell, v. 34, (6), September 2015, p. 632-641
Xu, Jin; Zhu, Lu; He, Sicong; Wu, Yi; Jin, Wan; Yu, Tao; Qu, Jianan Y.; Wen, Zilong
Article

2014 4

IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and basal random motility in a zebrafish injury-induced inflammation model

Journal of Immunology, v. 192, (12), June 2014, p. 5998-6008
Yan, Bo; Han, Peidong; Pan, Lifeng; Lu, Wei; Xiong, Jingwei; Zhang, Mingjie; Zhang, Wenqing; Li, Li; Wen, Zilong
Article

In Vivo Micro-Vascular Imaging and Flow Cytometry in Zebrafish Using Two-photon Excited Endogenous Fluorescence

Biomedical Optics Express, v. 5, (3), 2014, p. 653-663
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan
Article

In Vivo Nonlinear Optical Imaging of Immune Responses: Tissue Injury and Infection

Biophysical Journal, v. 107, (10), 2014, p. 2436-2443
Zeng, Yan; Yan, Bo; Xu, Jin; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan
Article

Nonlinear optical microscopy for in vivo imaging microvasculature and blood flow

Conference Proceedings: Biomedical Optics, 2014, article number BM4A.2
Zeng, Yan; Yan, Bo; Sun, Qiqi; He, Sicong; Jiang, Jun; Wen, Zilong; Qu, Jianan
Conference paper

2013 4

Hemogenic Endothelium Specification and Hematopoietic Stem Cell Maintenance Employ Distinct Scl Isoforms

Development (Cambridge), v. 140, (19), October 2013, p. 3977-3985
Zhen, Fenghua; Lan, Yahui; Yan, Bo; Zhang, Wenqing; Wen, Zilong
Article

Label-Free in Vivo Imaging of Human Leukocytes Using Two-photon Excited Endogenous Fluorescence

Journal of Biomedical Optics, v. 18, (4), 2013, article number 040504
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan
Article

Suppression of Pu.1 Function Results in Expanded Myelopoiesis in Zebrafish

Leukemia, v. 27, (9), September 2013, p. 1913-1917
Sun, Jiping; Liu, Wei; Li, Li; Chen, Jiahao; Wu, Mei; Zhang, Yiyue; Leung, Anskar; Zhang, Wenqing; Wen, Zilong; Liao, Wangjun
Article

Two-Photon Excited Endogenous Fluorescence for Label-Free in Vivo Imaging Ingestion of Disease-Causing Bacteria by Human Leukocytes

SPIE Proceedings, v. 8588, February 2013
Zeng, Yan; Yan, Bo; Sun, Qiqi; Teh, Seng Khoon; Zhang, Wei; Wen, Zilong; Qu, Jianan
Conference paper

2012 8

Antiparallel Coiled-coil-mediated Dimerization of Myosin X

Proceedings of the National Academy of Sciences of the United States of America, v. 109, (43), 2012, Oct, p. 17388-17393
Lu, Qing; Ye, Fei; Wei, Zhiyi; Wen, Zilong; Zhang, Mingjie
Article

Label-free in Vivo Flow Cytometry in Zebrafish Using Two-photon Autofluorescence Imaging

Optics Letters, v. 37, (13), 2012, Jul, p. 2490-2492
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan
Article

Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration

Journal of Biological Chemistry, v. 287, (30), 2012, Jul, p. 25353-25360
Li, Li; Yan, Bo; Shi, Yu-Qian; Zhang, Wen-Qing; Wen, Zi-Long
Article

Myelopoiesis during Zebrafish Early Development

Journal of Genetics and Genomics, v. 39, (9), 2012, Sep, p. 435-442
Xu, Jin; Du, Linsen; Wen, Zilong
Article

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

Developmental cell, v. 23, (6), December 2012, p. 1189-1202
Li, Ying; Du, Xu-fei; Liu, Chang-sheng; Wen, Zi-long; Du, Jiu-lin
Article

Runx1 Regulates Embryonic Myeloid Fate Choice in Zebrafish Through a Negative Feedback Loop Inhibiting Pu.1 Expression

Blood, v. 119, (22), 2012, Jun, p. 5239-5249
Jin, Hao; Li, Li; Xu, Jin; Zhen, Fenghua; Zhu, Lu; Liu, Pu Paul; Zhang, Mingjie; Zhang, Wenqing; Wen, Zilong
Article

SUMO1-activating Enzyme Subunit 1 Is Essential for the Survival of Hematopoietic Stem/Progenitor Cells in Zebrafish

Development (Cambridge), v. 139, (23), 2012, Dec, p. 4321-4329
Li, Xiuling; Lan, Yahui; Xu, Jin; Zhang, Wenqing; Wen, Zilong
Article

In vivo cytometry using two-photon autofluorescence microscopy

Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America), Miami, Florida, United States, 28 Apr - 2 May, 2012
Zeng, Yan; Xu, Jin; Li, Dong; Li, Li; Wen, Zilong; Qu, Jianan
Conference paper

2011 4

CMyb Regulates Hematopoietic Stem/Progenitor Cell Mobilization during Zebrafish Hematopoiesis

Blood, v. 118, (15), 2011, Oct, p. 4093-4101
Zhang, Yiyue; Jin, H.; Li, L.; Qin, F.X.F.; Wen, Z.
Article

Erythrocytes in the trunk of zebrafish embryos

Development, v. 138, (18), September 2011, p. 3862-3863
Jin, Hao; Wen, Zilong
Article

Irf8 Regulates Macrophage Versus Neutrophil Fate During Zebrafish Primitive Myelopoiesis

Blood, v. 117, (4), 2011, p. 1359-1369
Li, Li; Jin, Hao; Xu, Jin; Shi, Yuqian; Wen, Zilong
Article

Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis

Development, v. 138, (4), 2011, Jan, p. 619-629
Du, Linsen; Xu, J.; Li, Xiuling; Ma, Ning; Liu, Yanmei; Peng, Jinrong; Osato, Motomi; Zhang, Wenqing; Wen, Zilong
Article

2010 3

A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells

Stem Cells, v. 28, (10), 2010, p. 1869-1881
Ng, Cherry Ee Lin; Yokomizo, Tomomasa; Yamashita, Namiko; Cirovic, Branko; Jin, Hao; Wen, Zilong; Ito, Yoshiaki; Osato, Motomi
Article

Development of Multilineage Adult Hematopoiesis in the Zebrafish with a Runx1 Truncation Mutation

Blood, v. 115, (14), 2010, APR 8, p. 2806-2809
Sood, Raman; English, Milton A.; Belele, Christiane L.; Jin, Hao; Bishop, Kevin; Haskins, Rebecca; McKinney, Mary Cathleen; Chahal, Jagman; Weinstein, Brant M.; Wen, Zilong; Liu, P. Paul
Article

Regulation of Gene Expression by FSP27 in White and Brown Adipose Tissue

BMC Genomics, v. 11, (1), 2010, JUL 22, Article number 446
Li, De; Zhang, Yinxin; Xu, Li; Zhou, Linkang; Wang, Yue; Xue, Bofu; Wen, Zilong; Li, Peng; Sang, Jianli
Article

2009 2

Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor

Molecular Cell, v. 33, (6), 2009, MAR 27, p. 692-703
Wang, Rui; Wei, Zhiyi; Jin, Hao; Wu, Hao; Yu, Cong; Wen, Wenyu; Chan, Ling Nga; Wen, Zilong; Zhang, Mingjie
Article

Definitive Hematopoietic Stem/progenitor Cells Manifest Distinct Differentiation Output in the Zebrafish VDA and PBI

Development, v. 136, (4), 2009, FEB 15, p. 647-654
Jin, Hao; Sood, Raman; Xu, Jin; Zhen, Fenghua; English, Milton A.; Liu, Pu Paul; Wen, Zilong
Article

2008 2

Mypt1-mediated Spatial Positioning of Bmp2-producing Cells is Essential for Liver Organogenesis

Development, v. 135, (19), 2008, p. 3209-3218
Huang, Honghui; Ruan, Hua; Aw, Meng Yuan; Hussain, Alamgir; Guo, Lin; Gao, Chuan; Qian, Feng; Leung, Thomas; Song, Haiwei; Kimelman, David; Wen, Zilong; Peng, Jinrong
Article

Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

PloS One, v. 3, (8), 2008, AUG 6
Toh, Shen Yon; Gong, Jingyi; Du, Guoli; Li, John Zhong; Yang, Shuqun; Ye, Jing; Yao, Huilan; Zhang, Yinxin; Xue, Bofu; Li, Qing; Yang, Hongyuan; Wen, Zilong; Li, Peng
Article

2007 5

Amotl2 is Essential for Cell Movements in Zebrafish Embryo and Regulates C-Src Translocation

Development, v. 134, (5), March 2007, p. 979-988
Huang, Huizhe; Lu, Fu-I; Jia, Shunji; Meng, Shu; Cao, Ying; Wang, Yeqi; Ma, Weiping; Yin, Kun; Wen, Zilong; Peng, Jingrong; Thisse, Christine; Thisse, Bernard; Meng, Anming
Article

Cideb Regulates Diet-induced Obesity, Liver Steatosis, and Insulin Sensitivity by Controlling Lipogenesis and Fatty Acid Oxidation

Diabetes, v. 56, (10), 2007, OCT, p. 2523-2532
Li, John Zhong; Ye, Jing; Xue, Bofu; Qi, Jingzhong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong; Li, Peng
Article

Distinct Functions for Different Scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis

PLoS Biology, v. 5, (5), May 2007, p. 1110-1119
Qian, Feng; Zhen, Fenghua; Xu, Jin; Huang, Mei; Li, Wanyu; Wen, Zilong
Article

Migratory Path of Definitive Hematopoietic Stem/progenitor Cells During Zebrafish Development

Blood, v. 109, (12), 2007, p. 5208-5214
Jin, Hao; Xu, Jin; Wen, Zilong
Article

The Zebrafish Udu Gene Encodes a Novel Nuclear Factor and is Essential for Primitive Erythroid Cell Development

Blood, v. 110, (1), 1 July 2007, p. 99-106
Liu, Yanmei; Du, Linsen; Osato, Motomi; Teo, Eng Hui; Qian, Feng; Jin, Hao; Zhen, Fenghua; Xu, Jin; Guo, Lin; Huang, Honghui; Chen, J.; Geisler, Robert; Jiang, Yun-Jin; Peng, Jinrong; Wen, Zilong
Article

2006 1

The 5′ zebrafish scl promoter targets transcription to the brain, spinal cord, and hematopoietic and endothelial progenitors

Developmental Dynamics, v. 235, (1), January 2006, p. 60-67
Jin, Hao; Xu, Jin; Qian, Feng; Du, Linsen; Tan, Chee Yong; Lin, Zhixin; Peng, Jinrong; Wen, Zilong
Article

2005 4

Genome-wide identification of female-enriched genes in zebrafish

Developmental Dynamics, v. 232, (1), January 2005, p. 171-179
Wen, Chaoming; Zhang, Zhenhai; Ma, Weiping; Xu, Min; Wen, Zilong; Peng, Jinrong
Article

Identification of the Conserved Serine/threonine Residues Important for Gibberellin-sensitivity of Arabidopsis RGL2 Protein

Plant Journal, v. 44, (1), October 2005, p. 88-99
Hussain, Alamgir; Cao, Dongni; Cheng, Hui; Wen, Zilong; Peng, Jinrong
Article

Loss of Function of Def Selectively Up-regulates Δ113p53 Expression to Arrest Expansion Growth of Digestive Organs in Zebrafish

Genes and Development, v. 19, (23), 1 December 2005, p. 2900-2911
Chen, Jun; Ruan, Hua; Ng, Sok Meng; Gao, Chuan; Soo, Hui Meng; Wu, Wei; Zhang, Zhenhai; Wen, Zilong; Lane, David P.; Peng, Jinrong
Article

Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes

Developmental Dynamics, v. 233, (3), July 2005, p. 1163-1172
Qian, Feng; Zhen, Fenghua; Ong, Chinthing; Jin, Suk-Won; Soo, Hui Meng; Stainier, Didier Y.R.; Lin, Shuo; Peng, Jinrong; Wen, Zilong
Article

2003 2

15000 Unique Zebrafish EST Clusters and Their Future Use in Microarray for Profiling Gene Expression Patterns During Embryogenesis

Genome Research, v. 13, (3), 2003, p. 455-466
Lo, Jane; Lee, Sorcheng; Xu, Min; Liu, Feng; Ruan, Hua; Eun, Alvin; He, Yawen; Ma, Weiping; Wang, Weefuen; Wen, Zilong; Peng, Jinrong
Article

Emergence of a coronavirus infectious bronchitis virus mutant with a truncated 3b gene: Functional characterization of the 3b protein in pathogenesis and replication

Virology, v. 311, (1), 20 June 2003, p. 16-27
Shen, Shuo; Wen, Zilong; Liu, Dingxiang
Article

2002 3

Cloning and Expression Pattern of the lysozyme C Gene in Zebrafish

Mechanisms of Development, v. 113, (1), 2002, p. 69-72
Liu, Feng; Wen, Zilong
Article

Morphologic transformation of the thymus in developing zebrafish

Developmental Dynamics, v. 225, (1), September 2002, p. 87-94
Lam, Siewhong; Chua, H. L.; Gong, Zhiyuan; Wen, Zilong; LAM, Toongjin; SIN, Yokemin
Article

The chromatin-remodelling factor BRG1 selectively activates a subset of interferon α-inducible genes

Nature Cell BIiology, v. 4, (10), Oct 2002, p. 774-781
Huang, Mei; Qian, Feng; Hu, Yuanyu; Ang, Chengeng; Li, Zhong; Wen, Zilong
Article

1999 1

The Linker Domain of Stat1 is Required for Gamma Interferon-driven Transcription

Molecular and Cellular Biology, v. 19, (7), 1999, p. 5016-5112
Yang, Edward; Wen, Zilong; Haspel, Richard L.; Zhang, Jue J.; Darnell, James E.
Article

1997 3

Mapping of Stat3 Serine Phosphorylation to a Single Residue (727) and Evidence that Serine Phosphorylation has no Influence on DNA Binding of Stat1 and Stat3

Nucleic Acids Research, v. 25, (11), 1997, p. 2062-2067
Wen, Zilong; Darnell, James E.
Article

STAT signaling is active during early mammalian development

Developmental Dynamics, v. 208, (2), 1997, February, p. 190-198
Duncan, Stephen A.; Zhong, Zhong; Wen, Zilong; Darnell, James E.
Article

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

Molecular and Cellular Biology, v. 17, (11), 1997, November, p. 6618-6623
Wen, Zilong; Xu, Liangzhong; Darnell, James E.; Zhu, Xuejun
Article

1996 1

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon γ

Proceedings of the National Academy of Sciences of the United States of America, v. 93, (15), 1996, July, p. 7673-7678
Bromberg, Jacqueline F.; Horvath, Curt M.; Wen, Zilong; Schreiber, Robert D.; Darnell, James E.
Article

1995 6

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

Genes and Development, v. 9, (8), 1995, p. 984-994
Horvath, Curt M.; Wen, Zilong; Darnell, James E.
Article

Distribution of the mammalian Stat gene family in mouse chromosomes

Genomics, v. 29, (1), 1995, p. 225-228
Zhong, Zhong; Wen, Zilong; Darnell, James E.; Mui, Alice; Miyajima, Atsushi; Gilbert, Debra J.; Schindler, Christian W.; Quelle, Frederick W.; Ihle, James N.; Jenkins, Nancy A B G; Copeland, Neal G L F
Article

In Vivo Growth Hormone Treatment Rapidly Stimulates the Tyrosine Phosphorylation and Activation of Stat3

Molecular Endocrinology, v. 9, (2), 1995, p.171-177
Gronowski, Ann M.; Zhong, Zhong; Wen, Zilong; Thomas, Michael J.; Rotwein, Peter S.; Darnell, James E.
Article

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phopshorylation

Cell, v. 82, (2), 1995, July, p. 241-250
Wen, Zilong; Zhong, Zhong; Darnell, James E.
Article

Stat3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase

Proceedings of the National Academy of Sciences of the United States of America, v. 92, (15), 1995, July, p. 6915-6919
Boulton, Teri G.; Zhong, Zhong; Wen, Zilong; Darnell, James E.; Stahl, Neil; Yancopouloš, George D.
Article

The Genomic Structure of the STAT Genes-multiple Exons in Coincident Sites in STAT1 and STAT2

Nucleic Acids Research, v. 23, (3), 1995, February, p. 459-463
Qureshi, Sajjad A.; Yan, Riqiang; Zhong, Zhong; Wen, Zilong; Darnell, James E.
Article

1994 3

Epidermal Growth Factor and Lipopolysaccharide Activate Stat3 Transcription Factor in Mouse Liver

Journal of Biological Chemistry, v. 269, (35), 1994, Septermber, p. 21933-21935
Ruff-Jamison, Susan; Zhong, Zhong; Wen, Zilong; Chen, Katherine; Darnell, James E.; Cohen, Stanley W.
Article

Stat3 and Stat4: members of the family of signal transducers and activators of transcription

Proceedings of the National Academy of Sciences of the United States of America, v. 91, (11), 1994, May, p. 4806-4810
Zhong, Zhong; Wen, Zilong; Darnell, James E.
Article

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

Science, v, 264, (5155), 1994, p. 95-98
Wen, Zilong; Zhong, Zhong; Darnell, James E.
Article

1993 1

Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition

Immunology, v. 151, (10) 15 November 1993, p. 5387-5397
Solheim, Joyce C.; Carreño, Beatriz M.; Smith, Joseph D.; Gorka, John; Myers, Nancy B.; Wen, Zilong; Martinko, John M.; Lee, David R.; Hansen, Ted H.
Article

1992 2

Interaction of an α-melanocyte-stimulating hormone-diphtheria toxin fusion protein with melanotropin receptors in human melanoma metastases

Cancer Research, v. 52, (9), 1992, p. 2545-2548
Tatro,Jeffrey B.; Wen, Zilong; Entwistle, Margaret L.; Atkin, Michael B.; Smith, Thomas J.; Reichlin, Seymour; Murphy, John R.
Article

Phe496 and Leu497 are Essential for Receptor Binding and Cytotoxic Action of Murine Interleukin-4 Receptor Targeted Fusion Toxin DAB389-mIL-4

Protein Engineering, Design and Selecition\tv. 5, (3), 1992, p. 241-248
Lakkis, Fadi G.; Landgraf, Bryan E.; Wen, Zilong; Strom, Terry B.; Murphy, John R.
Article

1991 1

Diphtheria toxin-related α-melanocyte-stimulating hormone Fusion Toxin: Internal in-frame Deletion from Thr387 to His485 Results in the Formation of a Highly Potent Fusion Toxin which is Resistant to Proteolytic Degradation

Journal of Biological Chemistry, v. 266, (19), 1991, p. 12289-12293
Wen, Zilong; Tao, Xu; Lakkis, Fadi G.; Kiyokawa, Tetsuyuki; Murphy, John R.
Article

1990 1

Cellular Processing of the Interleukin-2 Fusion Toxin DAB486-IL-2 and Efficient Delivery of Diphtheria Fragment A to the Cytosol of Target Cells Requires Arg194

Journal of Biological Chemistry, v. 265, (33), 1990, p. 20673-20677
Williams, Diane P.; Wen, Zilong; Watson, Rose Scott; Boyd, Jessica M.; Strom, Terry B.; Murphy, John R.
Article

Teaching Assignment

2023-24 Fall 0 2022-23 Summer 0 2022-23 Spring 1 2022-23 Winter 0 2022-23 Fall 1 2021-22 Summer 1

LIFS4981

Biochemistry and Cell Biology Project Research II

LIFS4971

Biochemistry and Cell Biology Project Research I

UROP4100G

Undergraduate Research Opportunities Series 4

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2020 to December 2023 (As of 30 September 2023)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

LI, Yunbo
Life Science
QU, Rui
Life Science
SUN, Zhaowei
Life Science
WANG, Youqi
Life Science
YANG, Zhiyong
Life Science
CHENG, Kefan
Life Science
HUANG, Ying
Life Science
LI, Si
Life Science
PHAM, Thi Giang
Life Science
ZHU, Hao
Life Science
TANG, Jinlin
Life Science
HASSAN, Shaoli
Life Science
TRINH, Thi Huong
Life Science
LIN, Guanzhen
Life Science
PAN, Hongru
Life Science

Graduated RPGs

Doctor of Philosophy

NGUYEN, Thi My Linh
Life Science( Completed in 2023 )
WU, Haowei
Life Science( Completed in 2023 )
ZHOU, Qiuxia
Life Science( Completed in 2023 )
FENG, Shachuan
Life Science( Completed in 2022 )
LOU, Liang
Life Science( Completed in 2022 )
ZHAO, Changlong
Life Science( Completed in 2022 )
ZHAO, Shizheng
Life Science( Completed in 2022 )
DAI, Yimei
Life Science( Completed in 2020 )
GUO, Weilin
Life Science( Completed in 2020 )
LIN, Xi
Life Science( Completed in 2020 )

Master of Philosophy

CHENG, Kefan (co-supervision)
Life Science( Completed in 2021 )
FU, Yiming (co-supervision)
Electronic and Computer Engineering( Completed in 2021 )

Projects

From January 2021 to December 2023

All Projects 13 Leading Projects 5 Participating Projects 8

Investigation of key regulatory pathways and identification of actionable targets via network biology for drug repurposing in MAP3K3-mutant cerebral cavernous vascular malformation

通過網絡生物學研究 MAP3K3突變的腦海綿狀血管畸形藥物再利用的關鍵調控通路和可操作靶點 Participating

RGC - General Research Fund
Project Team (HKUST)
WANG Jiguang (Lead)

WEN Zilong
2023 -
Stem cell-niche interactions in tissue maintenance and engineering

幹細胞與微環境互作在組織維持和組織工程中的應用 Participating

RGC - Theme-based Research Scheme
Project Team (HKUST)
XIE Ting (Lead)

CHEUNG Tom

GUO Yusong

LEUNG Danny Chi Yeu

LIU Kai

MAK Ho Yi

SUN Fei

WEN Zilong

WU Angela Ruohao

WU Zhenguo

YAN Yan
2022 -
The genetic networks controlling the fate determination of macrophages and neutrophils in zebrafish

控制斑馬魚巨噬細胞和中性粒細胞命運決定的遺傳網絡 Participating

RGC - General Research Fund
Project Team (HKUST)
WANG Jiguang (Lead)

WEN Zilong
2022 -
The development and immune function of metaphocytes in zebrafish barrier tissues

斑馬魚屏障組織中介遞細胞的發育和免疫功能研究 Participating

RGC - General Research Fund
Project Team (HKUST)
WANG Jiguang (Lead)

WEN Zilong
2022 -
The molecular control of microglia maintenance

小膠質細胞群體維持的分子機制 Participating

RGC - General Research Fund
Project Team (HKUST)
WANG Jiguang (Lead)

WEN Zilong
2021 -
Molecular Mechanisms of Cell Lineage Transition and Hematopoietic Tissue Formation subtopic 2: Blood cell progressive differentiation and programming mechanism

細胞譜系轉變與造血組織形成的編程機制項目之課題二血細胞逐級分化與編程機制 Participating

Ministry of Science and Technology of the People's Republic of China
Project Team (HKUST)
WEN Zilong
2019 -
A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases

以幹細胞方法解析神經退行性疾病的分子基礎 Participating

RGC - Theme-based Research Scheme
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

CHEUNG Tom

CHUNG Kenny K

FU Amy Kit Yu

QI Robert Zhong

QU Jianan

TSIM Karl Wah Keung

WEN Zilong

WONG Yung Hou

WU Zhenguo
2019 -
Hematopoietic Cell Development Leading

Croucher Foundation
Project Team (HKUST)
WEN Zilong (Lead)
2019 - 2022
The migratory path and regulation of hematopoietic stem cell migration during development

探究造血干細胞在斑馬魚發育過程中的遷移路徑及相關調控機制 Leading

RGC - General Research Fund
Project Team (HKUST)
WEN Zilong (Lead)
2019 - 2021
Development of infrared-mediated single cell-labeling and study of non-HSC-derived T cells in zebrafish

研發紅外光介導的單細胞標記技術以及研究斑馬魚中非造血幹細胞來源的T淋巴細胞 Leading

RGC - Collaborative Research Fund
Project Team (HKUST)
WEN Zilong (Lead)

QU Jianan

WANG Jiguang

WU Angela Ruohao
2018 - 2021
The role of phospholipid signaling in microglia colonization and small chemical compound screening in zebrafish

溶血磷脂酸信號途徑調控斑馬魚小膠質細胞神經組織定植作用及小分子化合物篩選 Leading

National Natural Science Foundation of China / Research Grants Council
Project Team (HKUST)
WEN Zilong (Lead)
2018 - 2021
Mechanistic basis of synaptic development, signalling and neuro-disorders

神經突觸的發育,信號轉導及經神疾病的分子機理 Leading

RGC - Areas of Excellence Scheme
Project Team (HKUST)
WEN Zilong (Lead)

LIU Kai

QU Jianan

WU Zhenguo

YAN Yan
2013 - 2022
State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)

分子神經科學國家重點實驗室（香港科技大學） Participating

Innovation and Technology Fund
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

CHOW King Lau

CHUNG Kenny K

GUO Zhihong

HUANG Pingbo

LIANG Chun

POON Randy Yat Choi

QI Robert Zhong

TSIM Karl Wah Keung

WEN Zilong

WONG Joseph Tin Yum

WONG Yung Hou

WU Zhenguo

ZHU Guang
2011 -