Aza-Achmatowicz rearrangement coupled with intermolecular aza-Friedel–Crafts enables total syntheses of uleine and aspidosperma alkaloids

Binding affinity between coronavirus spike protein and human ACE2 receptor

Discovery of P450-Modified Sesquiterpenoids Levinoids A-D through Global Genome Mining

Rapid Access to Divergent Fused Polycycles Via One-Pot A³ Coupling and Intramolecular Diels-Alder Reaction

A Photoactivatable Luminescent Motif through Ring-Flipping Isomerization for Multiple Photopatterning

Fast Delivery of Multifunctional NIR-II Theranostic Nanoaggregates Enabled by the Photoinduced Thermoacoustic Process

Thiamine carbene liganded gold(i) chloride catalyzes an efficient aldehyde–alkyne–amine coupling reaction in water

Water-Soluble Aggregation-Induced Emission Luminogens with Near-Infrared Emission for Advanced Phototheranostics

A stable complex in the uptake of daptomycin to bacterial membrane

Mechanistic approach to antibiotic resistance: Mode of action of daptomycin

Cry3Aa*SpyCatcher Fusion Crystals Produced in Bacteria as Scaffolds for Multienzyme Coimmobilization

Phenylacetyl pepstatin inhibitors of aspartyl proteases from Streptomyces varsoviensis

Phenylacetyl pepstatin inhibitors of aspartyl proteases from Streptomyces varsoviensis

Reconstitution of the biosynthetic machinery of the lasso peptide microcin J25

Thiamine carbene liganded gold (I) chloride catalyses an efficient aldehyde-alkyne-amine coupling reaction in water

Weak interaction with putative phosphatidyl glycerol head group is critical for the uptake of daptomycin to bacterial membrane

A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent

Listeria monocytogenes MenI Encodes a DHNA-CoA thioesterase necessary for menaquinone biosynthesis, cytosolic survival, and virulence

Substrate recognition and catalytic mechanism of the phosphate acyltransferase PlsX from Bacillus subtilis

Identification of an amphipathic peptide sensor of the Bacillus subtilis fluid membrane microdomains

Biochemical and structural characterization of CGI-58

Identification of an amphipathic peptide sensor of the fluid membrane microdomains in Bacillus subtilis

Mechanism-based inhibition of the essential thiamine-dependent enzyme of the vitamin K2 biosynthesis

Structural and kinetic investigation of the thiamine-dependent MenD from the Escherichia coli menaquinone biosynthetic pathway

Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in Vitamin K Biosynthesis

Two Active Site Arginines Are Critical Determinants of Substrate Binding and Catalysis in MenD: A Thiamine-dependent Enzyme in Menaquinone Biosynthesis

Development of inhibitors against the alternate active site of the thiamine-dependent enzyme in menaquinone biosynthesis

Lipid-associated nonfibrillar α-helical oligomers of α-synuclein by unsaturated fatty acid sensing in vitro

Structural and mechanistic investigation of the monotopic membrane localization of the methyltransferase UbiE in quinone biosynthesis

Structural basis for peripheral sensing of the membrane regions of increased fluidity

Structure and membrane interaction of the lipid II synthase MurG in Bacillus subtilis

Crystal Structure of the Thioesterification Conformation of Bacillus Subtilis O-succinylbenzoyl-CoA Synthetase Reveals a Distinct Substrate-binding Mode

Facile Formation of a Microporous Chitosan Hydrogel Based on Self-crosslinking

A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis

Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis

Generality of the novel thiamine-dependent catalysis medicated by an active tetrahedral intermediate in menaquinone biosynthesis

Investigation on the interaction between acyl-ACP and Bacillus subtilus PlsX from glycerophospholipid biosynthetic pathway

Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex

Mechanistic investigation on the thiocarboxylate formation in thiosugar biosynthesis

Overcoming the solubility limit of recombinant protein with chaperone co-expression to produce high soluble yield of Arabidopsis CGI-58

Role of two conserved arginine residues in the new thiamine catalysis mediated by a tetrahedral intermediate in menaquinone biosynthesis

Structural and mechanistic investigation of the UbiE monotopic membrane localization in coenzyme Q and vitamin K biosynthesis

Structural basis for peripheral sensing of membrane regions of increased fluidity

Structural basis of the membrane association of phosphate acyltransferase PlsX

Structural determinants for the formation of the tetrahedral intermediate in the thiamine-dependent catalysis of Escherichia coli MenD from the menaquinone biosynthetic pathway

Two-staged interaction of α-synuclein with unsaturated fatty acids

α-Synuclein senses unsaturated fatty acid in vitro to form lipid-associated nonfibrillar α-helical oligomers

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis

An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus Influenzae

Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate

Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis

Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex

Mechanistic investigation of the MoeZ-catalyzed thiocarboxylate formation in thiosugar biosynthesis

Structural and kinetic investigation of the thiamine-dependent MenD from the Escherichia coli menaquinone biosynthetic pathway

Structural and kinetic investigation of the thiamine-dependent MenD from the menaquinone biosynthetic pathway in Escherichia coli

Structural and mechanistic investigation of the membrane associated phosphate acyltransferase PlsX

Structural basis of substrate recognition of Bacillus subtilis BioF in biotin biosynthesis

Structural characterization of H. influenzae BioG reveals a conserved active site within a novel three-layered of α/β hydrolase fold

Structural elucidation and biochemical investigation of multi-functional states of Bacillus subtilis o-succinylbenzoyl-CoA synthetase

Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase

A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation

Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora

Microsecond Protein Folding Events Revealed by Time-Resolved Fluorescence Resonance Energy Transfer in a Microfluidic Mixer

Structural basis for the ATP-dependent configuration of adenylation active site in Bacillus subtilis o-Succinylbenzoyl-CoA synthetase

Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad

Observation of an unusual intermediate in SEPHCHC synthase (MenD) in the biosynthesis of menaquinone

Structural and kinetic evidence of a large conformational movement in formation of the first Michaelis complex of o-succinylbenzoyl-CoA synthetase.

Structural and mechanistic investigation of the transmembrane sn-glycerol-3-phosphate acyltransferase PlsY from Escherichia coli

Structural basis for the ATP-dependent configuration of adenylation active site in Bacillus subtilis o-succinylbenzoyl-CoA synthetase

Structural characterization of a small basic protein: the human G0/G1 switch gene 2 protein (hG0S2)

Structural investigation of an atypical acyl-CoA synthase involved in biotin synthesis of Bacillus subtilis

Structural investigation of the 'hot dog' folded thioesterase YbaW

Structure of the Escherichia coli hotdog thioesterase YbaW

A comparison of the diet and fine-scale distribution of sympatric Tibetan and red foxes in Qinghai, PR China

Cascade Biocatalysis by Multienzyme-Nanoparticle Assemblies

Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses

Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues

Molecular basis of the general base catalysis of an α/β- hydrolase catalytic triad

Beta-Synuclein forms various alpha-helix and alpha-pleated sheet structures with different unsaturated fatty acids

Characterization of the alpha-helical oligomer of alpha-synuclein formed in the presence of oleic acid

Crystal structures of the type II M. tuberculosis MenB support a unified induced-fit catalytic mechanism for the crotonase fold enzyme family

Ligand-dependent active site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogs

Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad

Observation of an Unusual Tetrahedral Intermediate in SEPHCHC Synthase (MenD) in the Biosynthesis of Menaquinone

Structural and catalytic roles of the NC-loop of the α/β-hydrolase MenH

Structural and kinetic characterization of a large conformational movement in the two-step catalysis of o-succinylbenzoyl-CoA synthetase

Structural and Kinetic Evidence of A Large Conformational Movement in Formation of the First Michaelis Complex of O-Succinylbenzoyl-CoA Synthetase

Structural and pre-steady state kinetic study of the ligand recognition mechanism of a noncanonical α/β-hydrolase fold enzyme MenH

Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase

Structure of the Escherichia coli Hotdog Thioesterase Ybaw

α/β Hydrolase fold enzymes exhibit both open and closed conformations: a case study with BioH

Crystal Structures of E. coli Native MenH and Two Active Site Mutants

Identification of a Hotdog Fold Thioesterase Involved in the Biosynthesis of Menaquinone in Escherichia coli

Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily

The thiamine-dependent enzyme of the vitamin K biosynthesis catalyzes reductive C-N bond ligation between nitroarenes and alpha-ketoacids

Molecular Basis of the General Base Catalysis of an α/β-hydrolase Catalytic Triad

Active Site Binding and Catalytic Role of Bicarbonate in 1,4-Dihydroxy-2-naphthoyl Coenzyme A Synthases from Vitamin K Biosynthetic Pathways

Characterization of 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in phylloquinone biosynthesis of Synechocystis sp. PCC 6803

Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model-A Unifying Proposal for Drug Action

Alpha-Synuclein forms an oligomeric alpha-helical structure in the presence of unsaturated fatty acids.

Crowding effect on calmodulin bakcbone dynamics

Crystal structure of E. coli (1R, 6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH) and its product complex.

Differentiation of solvation effect and macromolecular crowding effect

Discovery and characterization of an L-methionine gamma-lyase involved in Calicheamicin biosynthesis.

Investigation of the abnormal electrophoretic behavior of the hotdog thioesterase YbaW.

Structural and kinetic characterization of o-succinylbenzoyl-CoA synthetase in the menaquinone biosynthesis of Escherichia coli.

Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the crotonase fold superfamily

Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the crotonase fold superfamily

A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine

Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified

Stabilization of the Second Oxyanion Intermediate by 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase of the Menaquinone Pathway: Spectroscopic Evidence of the Involvement of a Conserved Aspartic Acid

A general synthesis of 6-substituted 5,6-dihydro-4-hydroxy-2H- pyran-2-ones and NMR studies in different solvents

Characterization of 1,4-dihydroxy-2-naphthoyl-CoA synthase in the phylloquinone biosynthesis of Synechocystis

Characterization of the non-heme catalase activity of an α/β fold protein from Mycobacterium tuberculosis

Characterization of the type II hot-dog thioesterase in biosynthesis of the nine-membered enediyne core of C-1027

Effects of macromolecular crowding on selected protein systems

Identification of active site residues involved in the second oxyanion hole in the catalysis of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB)

New Products for the Iterative Enediyne Core Polyketide Synthase

Production of a nonaketide by the iterative ten-membered enediyne core polyketide synthase in biosynthesis of calicheamicin

Recognition of the acyl carrier protein by the phosphopanteheinyl transferase domain of the enediyne polykeide synthase SgcE

A Bicarbonate Cofactor Modulates 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase in Menaquinone Biosynthesis of Escherichia coli

Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027

Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis

Structural change of the enterobactin synthetase in crowded solution and its relation to crowding-enhanced product specificity in nonribosomal enterobactin biosynthesis

Structure and Reactivity of Bacillus subtilis MenD Catalyzing the First Committed Step in Menaquinone Biosynthesis

Bicarbonate dependence in vitamin K biosynthesis

Characterization of a nonaketide precursor in biosynthesis of the nine-membered enediyne core of the antitumor antibiotic C-1027

Characterization of a type II hot-dog thioesterase in Calicheamicin biosynthesis

Chemoenzymatic synthesis of N-hydroxyamides from nitro- or nitroso- compounds using a thiamine-dependent enzyme from the menaquinone biosynthetic pathway

Evidence for a new precursor in the biosynthesis of the ten-membered enediyne antitumor antibiotic Calicheamicin

New insights into the catalytic mechanism of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) gained from the deuterium exchange of its substrate analogs

Search for the second enzyme in biosynthesis of the enediyne core of the antitumor antibiotic C-1027

Searching for enzymes in the biosynthesis of the ten-membered enediyne core of Calicheamicin γI1

Catalytic Mechanism of SHCHC Synthase in the Menaquinone Biosynthesis of Escherichia coli: Identification and Mutational Analysis of the Active Site Residues

Combination of beta-elimination and liquid chromatography/quadrupole time-of-flight mass spectrometry for the determination of O-glycosylation sites

Conjugation of Latent Membrane Protein (LMP)-2 Epitope to Gold Nanoparticles as Highly Immunogenic Multiple Antigenic Peptides for Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses in Vitro

Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative

Preferential Hydrolysis of Aberrant Intermediates by the Type II Thioesterase in Escherichia coli Nonribosomal Enterobactin Synthesis: Substrate Specificities and Mutagenic Studies on the Active-Site Residues

Crowding Effect on Protein Side Chain Dynamics

Evidence for a New Precursor in the Biosynthesis of the Nine-membered Enediyne Core of the Antitumor Antibiotics C-1027

Explorative investigation of protein organization in the enterobactin biosynthetic pathway

In vitro reconstitution of iterative type I polyketide synthases

Mutational studies on the active site residues of MenD in Bacillus subtilis menaquinone biosynthesis

Re-examination of the activity of 1, 4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in the menaquinone biosynthesis

The viral 3a protein plays a role in the cellular immune response to the SARS coronavirus infection

Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli

Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis

A new activity of the serine-histidine-aspartate catalytic triad: -Proton abstraction from a carbon acid in a reaction involved in menaquinonone biosynthesis

Comparative advantages conferred by an enzyme with a nanomolar Michaelis constant in the menaquinonone biosynthesis of Escherichia coli

Identification and characterization of a new intermediate and a new enzyme in the menaquinonone biosynthesis of Escherichia coli

Pre-steady-state characterization of the reaction catalyzed by (1R, 6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Quantitative characterization of the proofreading activity of a Type II thioesterase in nonribosomal enterobactin biosynthesis in Escherichia coli

Signals for the SARS coronavirus 3a protein intracellular localization and extracellular secretion

Structural changes in nonribosomal enterobactin synthetase under crowding conditions inherent to intracellular environment

The role of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in the menaquinonone biosynthesis of Escherichia coli

The role of macromolecular crowding in the nonribosomal synthesis of enterobactin in Escherichia coli

The role of protein 3a in cellular inflammatory response to infection by SARS coronavirus

Chip-based CE coupled to a quadrupole TOF mass spectrometer for the analysis of a glycopeptide

Determination of the stereochemistry of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate, a key intermediate in menaquinone biosynthesis

Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase

Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A{*}0201 restricted epitopes

Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death

Intracellular hydrogelation of small molecules inhibits bacterial growth

Menaquinone biosynthesis in Escherichia coli: Identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-l-carboxylate as a novel intermediate and re-evaluation of MenD activity

Solid-phase total synthesis and antimicrobial activities of loloatins A-D

Using beta-lactamase to trigger supramolecular hydrogelation

A phenylalanine-rich signal is required for localization of the SARS coronavirus 3a protein to plasma membrane and its extracellular release

Coordinative Effects of Macromolecular Crowding on the Two Functional Domains of Chorismate Mutase-Prephenate Dehydratase in the Bacterial Biosynthesis of Phenylalanine

Determination of the Stereochemistry of 2-Succinyl-5-Enolpyruvyl-6- Hydroxy -3-Cyclohexene-1-Carboxylic Acid (SEPHCHC), a Key Intermediate in Menaquinone Biosynthesis.

In Vivo Evidence for Interaction of the SARS Coronavirus 3a Protein with an Unknown Host Protein

Menaquinone Biosynthesis in Escherichia coli: Identification and Characterization of (1R, 6R)-2-Succinyl-6-Hydroxy-2,4- Cyclohexadiene-1-Carboxylate (SHCHC) Synthase

Menaquinone Biosynthesis in Escherichia coli: Identification of 2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexene-1-Carboxylate (SEPHCHC) as a Novel Intermediate and Re-evaluation of MenD Activity

Amino terminus of the SARS coronavirus protein 3a elicits strong, potentially protective humoral responses in infected patients

Fluorescent "light-up" bioprobes based on tetraphenylethylene derivatives with aggregation-induced emission characteristics

Channeling of Isochorismate by a Dynamic Enzyme Complex in Escherichia coli Biosynthesis of Menaquinone

Complete elucidation of the biosynthesis of menaquinone and utilization of the biosynthetic enzymes as targets for antibiotic development

Conjugation of Arginine Oligomers to Anti-cancer Drugs Sensitizes Multidrug Resistant Cancer Cells

Macromolecular Crowding Significantly Enhances the Intrinsic Catalytic Efficiency of Enterobactin-Specific Isochorismate Synthase

Protein 3a of SARS Coronavirus Interacts with an Unknown Human Host Protein, DKFZP434H132

SARS Coronavirus Protein 3a Contains Distinct Targeting Signals for Localization to a Perinuclear Region and the Plasma Membrane

Sensing of Macromolecular Crowding by Fluorescence Resonance Energy Transfer between Two Variants of Green Fluorescent Protein

Towards complete elucidation of the biosynthesis of menaquinone and its utilization as a drug target

B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein

Macrolactonization catalyzed by the terminal thioesterase domain of the nonribosomal peptide synthetase responsible for lichenysin biosynthesis

A Preformed Conformation Guides the Thermal Head-to-tail Macrocyclization of an Unactivated Linear Peptide in Solid State

Amino Terminus of the SARS Coronavirus Protein 3a Elicited Protective Humoral Responses in Patients Who Had Recovered from SARS.

Identification of Interactions between SARS ORF 3a and Human Host Proteins by a Yeast Two-Hybrid System

Macrolactonization Catalysed by the Terminal Thioesterase Domain of the Nonribosomal Peptide Synthetase Responsible for Lichenysin Biosynthesis

Solid-State Biomimetic Synthesis of Gramicidin S and Analogues

Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles

Facile solid-phase synthesis of cyclic decapeptide antibiotic streptocidins A-D

Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins

Optimization of antibacterial cyclic decapeptides

Synthesis and Cytotoxicity of Enediyne Prodrugs with 3-Hydroxy-4-(arylmethylidene)cyclodeca-1,5-diyne Scaffolds

Synthesis of gramicidin S and its analogues via an on-resin macrolactamization assisted by a predisposed conformation of the linear precursors

T-cell epitopes in Severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS

A Novel Phage-Based Approach to Discovery of Immunogenic Peptides for Immunotherapy of Nasopharyngeal Carcinoma

Biofunctional nanomagnets: Synthesis and Applications

Optimization of Cyclic Peptide Antibiotic Gramicidin S

Optimizing natural cyclic peptides to counter microbial resistance

Preorganization in cyclic peptide synthesis and its application to the optimization of natural antibacterial peptide products

Roles of Terminal Condensation Domain in Cyclosporine Biosynthesis

A chemical approach to generate molecular diversity based on the scaffold of cyclic decapeptide antibiotic tyrocidine A

Biomimetic synthesis of gramicidin S and analogues by enzymatic cyclization of linear precursors on solid support

Dissociation of antibacterial and hemolytic activities of an amphipathic peptide antibiotic

The biosynthesis of GDP-L-colitose: C-3 deoxygenation is catalyzed by a unique coenzyme B₆-dependent enzyme

Evolve Cyclic Peptide Antibiotics to Contain Microbial Resistance

Exploring Pre-organized Conformation of the Linear Gramicidin Precursor for Biomimetic Synthesis of Cyclopeptide Libraries

Identification of Viral Epitopes for Immunoglobulins from SARS Patients

An improved deblocking agent for direct Fmoc solid-phase synthesis of peptide thioesters

Substrate spectrum of tyrocidine thioesterase probed with randomized peptide N-acetylcysteamine thioesters

Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution

A Chemical Approach to Engineering of the Cyclic Decapeptide Antibiotic Tyrocidine A

A modified Fmoc method for direct solid-state synthesis of peptide thioesters and its application to total synthesis of Tyrocidine A

A-beta amyloidosis inhibitors from traditional Chinese medicines

Biomimetic Combinatorial Synthesis of Cyclic Peptide Libraries for Drug Discovery

Biomimetic Combinatorial Synthesis of Cyclic Peptide Libraries for Drug Discovery

Combinatorial Synthesis and Screening of a Cyclopeptide Library based on the Tyrocidine Scaffold

Oligomeric intermediates in amyloid-beta peptides fibrillogenesis arrested by N-terminal fusion are not neurotoxic

Parallel Solid-phase Synthesis of Streptocidins A~D through Spontaneous Self-cyclization of Their Linear Precursors

Parallel synthesis of Tyrocidine A analogues through spontaneous cyclization of peptide thioesters

Synthesis of Gramicidin S Analogues: Chemical versus Chemoenzymatic Approach

Synthesis of Gramicidin S by Conformation-dependent Cyclization of Its Linear Biosynthetic Precursor

Synthesis, characterization, and screening of positional scanning cyclopeptide libraries based on Tyrocidine scaffold

Traceless Biomimetic Synthesis of Tyrocidines

Traceless Solid-phase Synthesis of Streptocidins

Utilization of a substrate intramolecular hydrogen bond in catalysis by enterobactin thioesterase

Utilization of Thioesterase from Non-ribosomal Peptide Synthase in Biomimetic Synthesis of Gramicidin S

Insights into the branched-chain formation of mycarose: Methylation catalyzed by an (S)-adenosylmethionine-dependent methyltransferase

Phage display: A powerful tool in biomedical research

Recent Development on novel ZnS-based UV detectors

Designing small-molecule switches for protein-protein interactions

Biosynthesis of mycarose: Isolation and characterization of enzymes involved in the C-2 deoxygenation

Biosynthesis of yersiniose: Attachment of the two-carbon branched-chain is catalyzed by a thiamine pyrophosphate-dependent flavoprotein

Expression, purification, and characterization of TyIM1, an N,N-dimethyltransferase involved in the biosynthesis of mycaminose

Mechanistic studies of the inactivation of crotonase by (methylenecyclopropyl)formyl-CoA

Synthesis and phase-transition of 4-alkoxycarbonylphenyl 4'-n-alkoxy-2,3,5,6-tetrafluorobiphenyl-4-carboxylates

Mechanistic studies of the biosynthesis of 3,6-dideoxy sugars: Stereochemical analysis of C-3 deoxygenation

Novel fluorinated liquid crystals. Part 9. Synthesis and memomorphic properties of 4-(alkoxycarbonyl) phenyl 4-[(4-alkoxy-2,3,5,6-tetrafluorophenyl)ethynyl]benzoates

Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in Vitamin K Biosynthesis

Article

Two Active Site Arginines Are Critical Determinants of Substrate Binding and Catalysis in MenD: A Thiamine-dependent Enzyme in Menaquinone Biosynthesis

Article

Development of inhibitors against the alternate active site of the thiamine-dependent enzyme in menaquinone biosynthesis

Conference paper

Lipid-associated nonfibrillar α-helical oligomers of α-synuclein by unsaturated fatty acid sensing in vitro

Conference paper

Structural and mechanistic investigation of the monotopic membrane localization of the methyltransferase UbiE in quinone biosynthesis

Conference paper

Structural basis for peripheral sensing of the membrane regions of increased fluidity

Conference paper

Structure and membrane interaction of the lipid II synthase MurG in Bacillus subtilis

Conference paper

Crystal Structure of the Thioesterification Conformation of Bacillus Subtilis O-succinylbenzoyl-CoA Synthetase Reveals a Distinct Substrate-binding Mode

Article

Facile Formation of a Microporous Chitosan Hydrogel Based on Self-crosslinking

Article

A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis

Conference paper

Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis

Conference paper

Generality of the novel thiamine-dependent catalysis medicated by an active tetrahedral intermediate in menaquinone biosynthesis

Conference paper

Investigation on the interaction between acyl-ACP and Bacillus subtilus PlsX from glycerophospholipid biosynthetic pathway

Conference paper

Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex

Conference paper

Mechanistic investigation on the thiocarboxylate formation in thiosugar biosynthesis

Conference paper

Overcoming the solubility limit of recombinant protein with chaperone co-expression to produce high soluble yield of Arabidopsis CGI-58

Conference paper

Role of two conserved arginine residues in the new thiamine catalysis mediated by a tetrahedral intermediate in menaquinone biosynthesis

Conference paper

Structural and mechanistic investigation of the UbiE monotopic membrane localization in coenzyme Q and vitamin K biosynthesis

Conference paper

Structural basis for peripheral sensing of membrane regions of increased fluidity

Conference paper

Structural basis of the membrane association of phosphate acyltransferase PlsX

Conference paper

Structural determinants for the formation of the tetrahedral intermediate in the thiamine-dependent catalysis of Escherichia coli MenD from the menaquinone biosynthetic pathway

Conference paper

Two-staged interaction of α-synuclein with unsaturated fatty acids

Conference paper

α-Synuclein senses unsaturated fatty acid in vitro to form lipid-associated nonfibrillar α-helical oligomers

Conference paper

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

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A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis

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An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus Influenzae

Article

Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate

Article

Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis

Conference paper

Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex

Conference paper

Mechanistic investigation of the MoeZ-catalyzed thiocarboxylate formation in thiosugar biosynthesis

Conference paper

Structural and kinetic investigation of the thiamine-dependent MenD from the Escherichia coli menaquinone biosynthetic pathway

Conference paper

Structural and kinetic investigation of the thiamine-dependent MenD from the menaquinone biosynthetic pathway in Escherichia coli

Conference paper

Structural and mechanistic investigation of the membrane associated phosphate acyltransferase PlsX

Conference paper

Structural basis of substrate recognition of Bacillus subtilis BioF in biotin biosynthesis

Conference paper

Structural characterization of H. influenzae BioG reveals a conserved active site within a novel three-layered of α/β hydrolase fold

Conference paper

Structural elucidation and biochemical investigation of multi-functional states of Bacillus subtilis o-succinylbenzoyl-CoA synthetase

Conference paper

Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase

Conference paper

A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation

Article

Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora

Article

Microsecond Protein Folding Events Revealed by Time-Resolved Fluorescence Resonance Energy Transfer in a Microfluidic Mixer

Article

Structural basis for the ATP-dependent configuration of adenylation active site in Bacillus subtilis o-Succinylbenzoyl-CoA synthetase

Article

Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad

Conference paper

Observation of an unusual intermediate in SEPHCHC synthase (MenD) in the biosynthesis of menaquinone

Conference paper

Structural and kinetic evidence of a large conformational movement in formation of the first Michaelis complex of o-succinylbenzoyl-CoA synthetase.

Conference paper

Structural and mechanistic investigation of the transmembrane sn-glycerol-3-phosphate acyltransferase PlsY from Escherichia coli

Conference paper

Structural basis for the ATP-dependent configuration of adenylation active site in Bacillus subtilis o-succinylbenzoyl-CoA synthetase

Conference paper

Structural characterization of a small basic protein: the human G0/G1 switch gene 2 protein (hG0S2)

Conference paper

Structural investigation of an atypical acyl-CoA synthase involved in biotin synthesis of Bacillus subtilis

Conference paper

Structural investigation of the 'hot dog' folded thioesterase YbaW

Conference paper

Structure of the Escherichia coli hotdog thioesterase YbaW

Conference paper

A comparison of the diet and fine-scale distribution of sympatric Tibetan and red foxes in Qinghai, PR China

Article

Cascade Biocatalysis by Multienzyme-Nanoparticle Assemblies

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Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses

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