Faculty Profiles - LIU Zhen | The Hong Kong University of Science and Technology

Zhen LIU
劉振

Doctor of Natural Science in Biophysics
Peking University, 2015

Assistant Professor
Division of Life Science

(852) 3469 2553
zhenliu@ust.hk
Room 5522
Personal Web

Google Scholar

1GlcxM4AAAAJ

ORCID

0000-0001-6462-8575

Scopus ID

57215841488

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Cell biology
Super-resolution microscopy
Disease mechanisms
Centrosome and cilia

Publications

All Years 14 2026 2 2025 1 2024 2 2023 0 2022 2 2021 0 2020 7

2026 2

Ana1/Cep295 regulates centriole elongation via Cep135 and microtubules

Journal of Cell Biology, v. 225, (10), p. 1-S6
Wang, Zhenjie; Qian, Yuxuan; Wang, Xuan; Ng, Qianyu; Zhang, Hanxi; Wu, Yang; Liu, Zhen; Feng, Zhe
Article

Loss of RPGR disrupts motile cilia and causes primary ciliary dyskinesia by affecting F-actin dynamics

Journal of Clinical Investigation, v. 136, (10)
WU, Yang; Tavares, Erika; LIANG, Binrun; Wee, Wallace; Mennella, Vito; FENG, Hanchao; CAO, Jiaying; WONG, Pui Yee; ZHENG, Jiayi; He, Mu; Stephenson, Kirk; Hanan, Liran; LI, Min; Chen, Nan Peng; Dell, Sharon D.; Heon, Elise; LIU, Zhen
Article

2025 1

The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity

Proceedings of the National Academy of Sciences of the United States of America, v. 122, (51), article number e2515392122
Park, Hyunji; Choi, Minjun; Zhang, Yu; Cheung, Helen Oi Lam; Makino, Shigeru; Yoshikawa, Yoshiaki; Qi, Haoran; Liu, Zheng; Lan, Guocheng; Fu, Guoling; Wang, Qian; Guo, Shiny Shengzhen; Liu, Pengtao; Liu, Zhen; Ti, Shih Chieh; Wang, Won Jing; Li, Xiang David; Ni, Tao; Hui, Chi Chung; He, Mu
Article

2024 2

Super-Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis (Invited)

Laser and Optoelectronics Progress, v. 61, (6), article number 0618016
Zhen, Liu; Yang, Wu
Article

Highly Multiplexed Protein Detection in Situ with Rolling Circle Amplification (RCA) Assisted Cyclic Color-Combinatorial Fluorescence in Situ Hybridization(ccc-FISH)

Paper presented at The 18th International Conference on Biomedical Engineering (ICBME 2024)
Cui, Binbin; Dong, Haorong; Wu, Yang; Liu, Zhen; Yao, Shuhuai
Conference paper

2022 2

Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of MUC5B

American Journal of Respiratory and Critical Care Medicine, v. 205, (7), p. 761-768
Costain, Gregory; Liu, Zhen; Mennella, Vito; Radicioni, Giorgia; Goczi, Adrienn N.; Albulescu, Alexandra; Walker, Susan; Ngan, Bo; Manson, David; Vali, Reza; Khan, Meraj; Palaniyar, Nades; Hill, David B.; Hall, David A.; Marshall, Christian R.; Knowles, Michael; Zariwala, Maimoona A.; Kesimer, Mehmet; Dell, Sharon D.
Article

Nanometer-Scale Molecular Mapping by Super-resolution Fluorescence Microscopy

Methods in Molecular Biology / Humana Press Inc., 2022, p. 305-326
Mennella, Vito; Liu, Zhen
Book chapter

2020 4

A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies

Science Translational Medicine, v. 12, (535), article number eaay0071
Liu, Zhen; Nguyen, Quynh P.H.; Guan, Qingxu; Albulescu, Alexandra; Erdman, Lauren; Mahdaviyeh, Yasaman; Kang, Jasmine; Ouyang, Hong; Hegele, Richard G.; Moraes, Theo; Goldenberg, Anna; Dell, Sharon D.; Mennella, Vito
Article

Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia

Developmental Cell, v. 55, (2), p. 209-223.e7
Nguyen, Quynh P.H.; Liu, Zhen; Albulescu, Alexandra; Ouyang, Hong; Zlock, Lorna; Coyaud, Etienne; Laurent, Estelle; Finkbeiner, Walter; Moraes, Theo J.; Raught, Brian; Mennella, Vito
Article

Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells

Developmental Cell, v. 55, (2), p. 224-236.e6
Liu, Zhen; Nguyen, Quynh P.H.; Nanjundappa, Rashmi; Delgehyr, Nathalie; Megherbi, Alexandre; Doherty, Regan; Thompson, James; Jackson, Claire; Albulescu, Alexandra; Heng, Yew M.; Lucas, Jane S.; Dell, Sharon D.; Meunier, Alice; Czymmek, Kirk; Mahjoub, Moe R.; Mennella, Vito
Article

Hereditary Mucin Deficiency Caused by Biallelic Loss-of-Function of MUC5B Defines a Novel Category of Lung Disease

Paper presented at American Journal of Respiratory and Critical Care Medicine
Albulescu, Alexandra; Costain, Gregory; Dell, Sharon D.; Goczi, Adrienn; Liu, Zhen; Marshall, Christian R.; Ngan, Bo; Walker, Susan; Kesimer, Mehmet; Zariwala, Maimoona A.; Knowles, Michael; Mennella, Vito; Hall, David, A.
Conference paper

2015 1

Live-cell and super-resolution imaging reveal that the distribution of wall-associated protein A is correlated with the cell chain integrity of Streptococcus mutans

Molecular Oral Microbiology, v. 30, (5), p. 376-383
Li, Y.; Liu, Z.; Zhang, Y.; Su, Q. P.; Xue, B.; Shao, S.; Zhu, Y.; Xu, X.; Wei, S.; Sun, Y.
Article

2014 2

Super-resolution imaging and tracking of protein-protein interactions in sub-diffraction cellular space

Nature Communications, v. 5, article number 4443
Liu, Zhen; Xing, Dong; Su, Qian Peter; Zhu, Yun; Zhang, Jiamei; Kong, Xinyu; Xue, Boxin; Wang, Sheng; Sun, Hao; Tao, Yile; Sun, Yujie
Article

超高分辨率熒光顯微成像: 2014年諾貝爾化學獎解析

Kexue Tongbao/Chinese Science Bulletin, v. 59, p. 3342-3343
蘇乾; 劉振, Zhen; 薛博鑫; 孫育杰
Article

Article 2

Ana1/Cep295 regulates centriole elongation via Cep135 and microtubules

Journal of Cell Biology, v. 225, (10), p. 1-S6
Wang, Zhenjie; Qian, Yuxuan; Wang, Xuan; Ng, Qianyu; Zhang, Hanxi; Wu, Yang; Liu, Zhen; Feng, Zhe

Loss of RPGR disrupts motile cilia and causes primary ciliary dyskinesia by affecting F-actin dynamics

Journal of Clinical Investigation, v. 136, (10)
WU, Yang; Tavares, Erika; LIANG, Binrun; Wee, Wallace; Mennella, Vito; FENG, Hanchao; CAO, Jiaying; WONG, Pui Yee; ZHENG, Jiayi; He, Mu; Stephenson, Kirk; Hanan, Liran; LI, Min; Chen, Nan Peng; Dell, Sharon D.; Heon, Elise; LIU, Zhen

Article 1

The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity

Proceedings of the National Academy of Sciences of the United States of America, v. 122, (51), article number e2515392122
Park, Hyunji; Choi, Minjun; Zhang, Yu; Cheung, Helen Oi Lam; Makino, Shigeru; Yoshikawa, Yoshiaki; Qi, Haoran; Liu, Zheng; Lan, Guocheng; Fu, Guoling; Wang, Qian; Guo, Shiny Shengzhen; Liu, Pengtao; Liu, Zhen; Ti, Shih Chieh; Wang, Won Jing; Li, Xiang David; Ni, Tao; Hui, Chi Chung; He, Mu

Article 1

Super-Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis (Invited)

Laser and Optoelectronics Progress, v. 61, (6), article number 0618016
Zhen, Liu; Yang, Wu

Conference paper 1

Highly Multiplexed Protein Detection in Situ with Rolling Circle Amplification (RCA) Assisted Cyclic Color-Combinatorial Fluorescence in Situ Hybridization(ccc-FISH)

Paper presented at The 18th International Conference on Biomedical Engineering (ICBME 2024)
Cui, Binbin; Dong, Haorong; Wu, Yang; Liu, Zhen; Yao, Shuhuai

Article 1

Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of MUC5B

American Journal of Respiratory and Critical Care Medicine, v. 205, (7), p. 761-768
Costain, Gregory; Liu, Zhen; Mennella, Vito; Radicioni, Giorgia; Goczi, Adrienn N.; Albulescu, Alexandra; Walker, Susan; Ngan, Bo; Manson, David; Vali, Reza; Khan, Meraj; Palaniyar, Nades; Hill, David B.; Hall, David A.; Marshall, Christian R.; Knowles, Michael; Zariwala, Maimoona A.; Kesimer, Mehmet; Dell, Sharon D.

Book chapter 1

Nanometer-Scale Molecular Mapping by Super-resolution Fluorescence Microscopy

Methods in Molecular Biology / Humana Press Inc., 2022, p. 305-326
Mennella, Vito; Liu, Zhen

Article 3

A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies

Science Translational Medicine, v. 12, (535), article number eaay0071
Liu, Zhen; Nguyen, Quynh P.H.; Guan, Qingxu; Albulescu, Alexandra; Erdman, Lauren; Mahdaviyeh, Yasaman; Kang, Jasmine; Ouyang, Hong; Hegele, Richard G.; Moraes, Theo; Goldenberg, Anna; Dell, Sharon D.; Mennella, Vito

Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia

Developmental Cell, v. 55, (2), p. 209-223.e7
Nguyen, Quynh P.H.; Liu, Zhen; Albulescu, Alexandra; Ouyang, Hong; Zlock, Lorna; Coyaud, Etienne; Laurent, Estelle; Finkbeiner, Walter; Moraes, Theo J.; Raught, Brian; Mennella, Vito

Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells

Developmental Cell, v. 55, (2), p. 224-236.e6
Liu, Zhen; Nguyen, Quynh P.H.; Nanjundappa, Rashmi; Delgehyr, Nathalie; Megherbi, Alexandre; Doherty, Regan; Thompson, James; Jackson, Claire; Albulescu, Alexandra; Heng, Yew M.; Lucas, Jane S.; Dell, Sharon D.; Meunier, Alice; Czymmek, Kirk; Mahjoub, Moe R.; Mennella, Vito

Conference paper 1

Hereditary Mucin Deficiency Caused by Biallelic Loss-of-Function of MUC5B Defines a Novel Category of Lung Disease

Paper presented at American Journal of Respiratory and Critical Care Medicine
Albulescu, Alexandra; Costain, Gregory; Dell, Sharon D.; Goczi, Adrienn; Liu, Zhen; Marshall, Christian R.; Ngan, Bo; Walker, Susan; Kesimer, Mehmet; Zariwala, Maimoona A.; Knowles, Michael; Mennella, Vito; Hall, David, A.

Article 1

Live-cell and super-resolution imaging reveal that the distribution of wall-associated protein A is correlated with the cell chain integrity of Streptococcus mutans

Molecular Oral Microbiology, v. 30, (5), p. 376-383
Li, Y.; Liu, Z.; Zhang, Y.; Su, Q. P.; Xue, B.; Shao, S.; Zhu, Y.; Xu, X.; Wei, S.; Sun, Y.

Article 2

Super-resolution imaging and tracking of protein-protein interactions in sub-diffraction cellular space

Nature Communications, v. 5, article number 4443
Liu, Zhen; Xing, Dong; Su, Qian Peter; Zhu, Yun; Zhang, Jiamei; Kong, Xinyu; Xue, Boxin; Wang, Sheng; Sun, Hao; Tao, Yile; Sun, Yujie

超高分辨率熒光顯微成像: 2014年諾貝爾化學獎解析

Kexue Tongbao/Chinese Science Bulletin, v. 59, p. 3342-3343
蘇乾; 劉振, Zhen; 薛博鑫; 孫育杰

2020 4

A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies

Science Translational Medicine, v. 12, (535), article number eaay0071
Liu, Zhen; Nguyen, Quynh P.H.; Guan, Qingxu; Albulescu, Alexandra; Erdman, Lauren; Mahdaviyeh, Yasaman; Kang, Jasmine; Ouyang, Hong; Hegele, Richard G.; Moraes, Theo; Goldenberg, Anna; Dell, Sharon D.; Mennella, Vito
Article

Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia

Developmental Cell, v. 55, (2), p. 209-223.e7
Nguyen, Quynh P.H.; Liu, Zhen; Albulescu, Alexandra; Ouyang, Hong; Zlock, Lorna; Coyaud, Etienne; Laurent, Estelle; Finkbeiner, Walter; Moraes, Theo J.; Raught, Brian; Mennella, Vito
Article

Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells

Developmental Cell, v. 55, (2), p. 224-236.e6
Liu, Zhen; Nguyen, Quynh P.H.; Nanjundappa, Rashmi; Delgehyr, Nathalie; Megherbi, Alexandre; Doherty, Regan; Thompson, James; Jackson, Claire; Albulescu, Alexandra; Heng, Yew M.; Lucas, Jane S.; Dell, Sharon D.; Meunier, Alice; Czymmek, Kirk; Mahjoub, Moe R.; Mennella, Vito
Article

Hereditary Mucin Deficiency Caused by Biallelic Loss-of-Function of MUC5B Defines a Novel Category of Lung Disease

Paper presented at American Journal of Respiratory and Critical Care Medicine
Albulescu, Alexandra; Costain, Gregory; Dell, Sharon D.; Goczi, Adrienn; Liu, Zhen; Marshall, Christian R.; Ngan, Bo; Walker, Susan; Kesimer, Mehmet; Zariwala, Maimoona A.; Knowles, Michael; Mennella, Vito; Hall, David, A.
Conference paper

2015 1

Live-cell and super-resolution imaging reveal that the distribution of wall-associated protein A is correlated with the cell chain integrity of Streptococcus mutans

Molecular Oral Microbiology, v. 30, (5), p. 376-383
Li, Y.; Liu, Z.; Zhang, Y.; Su, Q. P.; Xue, B.; Shao, S.; Zhu, Y.; Xu, X.; Wei, S.; Sun, Y.
Article

2014 2

Super-resolution imaging and tracking of protein-protein interactions in sub-diffraction cellular space

Nature Communications, v. 5, article number 4443
Liu, Zhen; Xing, Dong; Su, Qian Peter; Zhu, Yun; Zhang, Jiamei; Kong, Xinyu; Xue, Boxin; Wang, Sheng; Sun, Hao; Tao, Yile; Sun, Yujie
Article

超高分辨率熒光顯微成像: 2014年諾貝爾化學獎解析

Kexue Tongbao/Chinese Science Bulletin, v. 59, p. 3342-3343
蘇乾; 劉振, Zhen; 薛博鑫; 孫育杰
Article

No Publications

Teaching Assignment

2026-27 Fall 2 2025-26 Summer 2 2025-26 Spring 7 2025-26 Winter 0 2025-26 Fall 8 2024-25 Summer 3

LIFS5070	Workshops in Biosciences
LIFS6170	Special Topics in Molecular, Cell and Developmental Biology

UROP1000	Undergraduate Research Opportunities
UROP1100S	Undergraduate Research Opportunities Series 1

LIFS4630	Advanced Topics in Biotechnology
LIFS4910D	Independent Study
LIFS4963	Biotechnology Capstone Project
LIFS4983	Biotechnology Project Research II
LIFS6117I	Current Topics in Cell Biology
SCIE1500	Guided Study on Research I
UROP2100R	Undergraduate Research Opportunities Series 2

BIBU4850	Biotechnology and Business Project Research
LIFS4910D	Independent Study
LIFS4963	Biotechnology Capstone Project
LIFS4973	Biotechnology Project Research I
LIFS5070	Workshops in Biosciences
LIFS6170	Special Topics in Molecular, Cell and Developmental Biology
SCIE3500	IRE Research Project I
UROP1100Q	Undergraduate Research Opportunities Series 1

UROP1000	Undergraduate Research Opportunities
UROP3200	Undergraduate Research Opportunities with Mini-conference Experience
UROP4100P	Undergraduate Research Opportunities Series 4

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2023 to December 2026 (As of 10 September 2026)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

WONG, Pui Yee
Life Science
CAO, Jiaying
Life Science
ZHAO, Yanshuang
Life Science
DAI, Zixuan
Life Science
WU, Yang
Life Science
WANG, Qian
Life Science

Master of Philosophy

CHAN, Daniel
Life Science
DING, Hengyang
Life Science
LIU, Xue
Life Science

Graduated RPGs

Master of Philosophy

CAO, Jiaying
Life Science( Completed in 2025 )
LIANG, Binrun
Life Science( Completed in 2025 )
FENG, Hanchao
Life Science( Completed in 2024 )

Projects

From January 2024 to December 2026

All Projects 4

No Projects.
Primary ciliary dyskinesia diagnosis by advanced light microscopy

透過先進光學顯微鏡診斷原發性纖毛運動障礙癥 Leading

RGC - General Research Fund
Project Team (HKUST)
LIU Zhen (Lead)

CHEN Hao
2026 -
Cilia Beat Machinery: Gaining Insights through CRISPR Perturbation and Super-Resolution Imaging

透過 CRISPR 基因編輯和超分辨成像研究纖毛擺動機制 Leading

RGC - General Research Fund
Project Team (HKUST)
LIU Zhen (Lead)
2025 -
MTMR11 defect causes motile ciliopathy

MTMR11缺陷導致運動纖毛病變 Leading

RGC - General Research Fund
Project Team (HKUST)
LIU Zhen (Lead)
2024 -
A mechanistic study of RPGR defect caused airway and eye diseases

RPGR缺陷導致的呼吸道和眼部疾病的機制研究 Leading

RGC - Early Career Scheme
Project Team (HKUST)
LIU Zhen (Lead)
2022 - 2025

Research Interest

Publications

2026 2

2025 1

2024 2

2022 2

2020 4

2015 1

2014 2

Article 2

Article 1

Article 1

Conference paper 1

Article 1

Book chapter 1

Article 3

Conference paper 1

Article 1

Article 2

2020 4

2015 1

2014 2

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2023 to December 2026 (As of 10 September 2026)

Current RPGs

Graduated RPGs

Projects

From January 2024 to December 2026

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