Faculty Profiles - YIN Zhan | The Hong Kong University of Science and Technology

Zhan YIN
尹詹

PhD in Medical Sciences
University of Cambridge, 2021

Research Assistant Professor
Division of Life Science

(852) 2358 8401
zhanyin@ust.hk
Room 6301A

Google Scholar

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ORCID

0000-0002-3846-0147

ResearcherID

KCO-6635-2024

Scopus ID

57217021843

Research Interest Publications

Research Interest

Cellular and molecular mechanisms
Structural biology
Human DNA replication initiation
Drug development

Publications

All Years 11 2026 0 2025 0 2024 3 2023 2 2022 1 2021 1 2020 4

2024 3

CryoEM insights into RNA primer synthesis by the human primosome

FEBS Journal, v. 291, (8), p. 1813-1829, article number 10.1111/febs.17082
Yin, Zhan; Kilkenny, Mairi L.; Ker, De Sheng; Pellegrini, Luca
Article

Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I

Science, v. 384, (6701), p. 1247-1253
Grba, Daniel N.; Wright, John J.; Yin, Zhan; Fisher, William; Hirst, Judy
Article

Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4^−/− mouse

EMBO Journal, v. 43, (2), p. 225-249
Yin, Zhan; Agip, Ahmed Noor A.; Bridges, Hannah R.; Hirst, Judy
Article

2023 2

Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments

Journal of Muscle Research and Cell Motility, v. 44, (3), p. 165-178
Huang, Xinrui; Torre, Iratxe; Chiappi, Michele; Yin, Zhan; Vydyanath, Anupama; Cao, Shuangyi; Raschdorf, Oliver; Beeby, Morgan; Quigley, Bonnie; de Tombe, Pieter P.; Liu, Jun; Morris, Edward P.; Luther, Pradeep K.
Article

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides

Science, v. 379, (6630), p. 351-357
Bridges, Hannah R.; Blaza, James N.; Yin, Zhan; Chung, Injae; Pollak, Michael N.; Hirst, Judy
Article

2022 1

Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

Journal of Biological Chemistry, v. 298, (3), article number 101602
Grba, Daniel N.; Blaza, James N.; Bridges, Hannah R.; Agip, Ahmed Noor A.; Yin, Zhan; Murai, Masatoshi; Miyoshi, Hideto; Hirst, Judy
Article

2021 1

Structural basis for a complex I mutation that blocks pathological ROS production

Nature Communications, v. 12, (1), article number 707
Yin, Zhan; Burger, Nils; Kula-Alwar, Duvaraka; Aksentijević, Dunja; Bridges, Hannah R.; Prag, Hiran A.; Grba, Daniel N.; Viscomi, Carlo; James, Andrew M.; Mottahedin, Amin; Krieg, Thomas; Murphy, Michael P.; Hirst, Judy
Article

2020 1

Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration

ACS Synthetic Biology, v. 9, (6), p. 1450-1459
Biner, Olivier; Fedor, Justin G.; Yin, Zhan; Hirst, Judy
Article

2018 1

Structural basis of RIP2 activation and signaling

Nature Communications, v. 9, (1), article number 4993
Gong, Qin; Long, Ziqi; Zhong, Franklin L.; Teo, Daniel Eng Thiam; Jin, Yibo; Yin, Zhan; Boo, Zhao Zhi; Zhang, Yaming; Zhang, Jiawen; Yang, Renliang; Bhushan, Shashi; Reversade, Bruno; Li, Zongli; Wu, Bin
Article

2017 1

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

Scientific Reports, v. 7, (1), article number 5159
Wong, Chui Fann; Shin, Joon; Subramanian Manimekalai, Malathy Sony; Saw, Wuan Geok; Yin, Zhan; Bhushan, Shashi; Kumar, Arvind; Ragunathan, Priya; Grüber, Gerhard
Article

2016 1

Cryo-EM structure of the large subunit of the spinach chloroplast ribosome

Scientific Reports, v. 6, article number 35793
Ahmed, Tofayel; Yin, Zhan; Bhushan, Shashi
Article

Article 3

CryoEM insights into RNA primer synthesis by the human primosome

FEBS Journal, v. 291, (8), p. 1813-1829, article number 10.1111/febs.17082
Yin, Zhan; Kilkenny, Mairi L.; Ker, De Sheng; Pellegrini, Luca

Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I

Science, v. 384, (6701), p. 1247-1253
Grba, Daniel N.; Wright, John J.; Yin, Zhan; Fisher, William; Hirst, Judy

Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4^−/− mouse

EMBO Journal, v. 43, (2), p. 225-249
Yin, Zhan; Agip, Ahmed Noor A.; Bridges, Hannah R.; Hirst, Judy

Article 2

Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments

Journal of Muscle Research and Cell Motility, v. 44, (3), p. 165-178
Huang, Xinrui; Torre, Iratxe; Chiappi, Michele; Yin, Zhan; Vydyanath, Anupama; Cao, Shuangyi; Raschdorf, Oliver; Beeby, Morgan; Quigley, Bonnie; de Tombe, Pieter P.; Liu, Jun; Morris, Edward P.; Luther, Pradeep K.

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides

Science, v. 379, (6630), p. 351-357
Bridges, Hannah R.; Blaza, James N.; Yin, Zhan; Chung, Injae; Pollak, Michael N.; Hirst, Judy

Article 1

Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

Journal of Biological Chemistry, v. 298, (3), article number 101602
Grba, Daniel N.; Blaza, James N.; Bridges, Hannah R.; Agip, Ahmed Noor A.; Yin, Zhan; Murai, Masatoshi; Miyoshi, Hideto; Hirst, Judy

Article 1

Structural basis for a complex I mutation that blocks pathological ROS production

Nature Communications, v. 12, (1), article number 707
Yin, Zhan; Burger, Nils; Kula-Alwar, Duvaraka; Aksentijević, Dunja; Bridges, Hannah R.; Prag, Hiran A.; Grba, Daniel N.; Viscomi, Carlo; James, Andrew M.; Mottahedin, Amin; Krieg, Thomas; Murphy, Michael P.; Hirst, Judy

Article 1

Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration

ACS Synthetic Biology, v. 9, (6), p. 1450-1459
Biner, Olivier; Fedor, Justin G.; Yin, Zhan; Hirst, Judy

Article 1

Structural basis of RIP2 activation and signaling

Nature Communications, v. 9, (1), article number 4993
Gong, Qin; Long, Ziqi; Zhong, Franklin L.; Teo, Daniel Eng Thiam; Jin, Yibo; Yin, Zhan; Boo, Zhao Zhi; Zhang, Yaming; Zhang, Jiawen; Yang, Renliang; Bhushan, Shashi; Reversade, Bruno; Li, Zongli; Wu, Bin

Article 1

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

Scientific Reports, v. 7, (1), article number 5159
Wong, Chui Fann; Shin, Joon; Subramanian Manimekalai, Malathy Sony; Saw, Wuan Geok; Yin, Zhan; Bhushan, Shashi; Kumar, Arvind; Ragunathan, Priya; Grüber, Gerhard

Article 1

Cryo-EM structure of the large subunit of the spinach chloroplast ribosome

Scientific Reports, v. 6, article number 35793
Ahmed, Tofayel; Yin, Zhan; Bhushan, Shashi

2020 1

Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration

ACS Synthetic Biology, v. 9, (6), p. 1450-1459
Biner, Olivier; Fedor, Justin G.; Yin, Zhan; Hirst, Judy
Article

2018 1

Structural basis of RIP2 activation and signaling

Nature Communications, v. 9, (1), article number 4993
Gong, Qin; Long, Ziqi; Zhong, Franklin L.; Teo, Daniel Eng Thiam; Jin, Yibo; Yin, Zhan; Boo, Zhao Zhi; Zhang, Yaming; Zhang, Jiawen; Yang, Renliang; Bhushan, Shashi; Reversade, Bruno; Li, Zongli; Wu, Bin
Article

2017 1

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

Scientific Reports, v. 7, (1), article number 5159
Wong, Chui Fann; Shin, Joon; Subramanian Manimekalai, Malathy Sony; Saw, Wuan Geok; Yin, Zhan; Bhushan, Shashi; Kumar, Arvind; Ragunathan, Priya; Grüber, Gerhard
Article

2016 1

Cryo-EM structure of the large subunit of the spinach chloroplast ribosome

Scientific Reports, v. 6, article number 35793
Ahmed, Tofayel; Yin, Zhan; Bhushan, Shashi
Article

No Publications

Research Interest

Publications

2024 3

2023 2

2022 1

2021 1

2020 1

2018 1

2017 1

2016 1

Article 3

Article 2

Article 1

Article 1

Article 1

Article 1

Article 1

Article 1

2020 1

2018 1

2017 1

2016 1

Projects

From January 2024 to December 2026

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