Faculty Profiles - GUO Yusong | The Hong Kong University of Science and Technology

Yusong GUO
郭玉松

PhD in Biological Sciences
Carnegie Mellon University, 2008

Associate Professor
Division of Life Science

UG Programs Coordinator (Life Science)

(852) 3469 2492
guoyusong@ust.hk
Room 5530
Personal Web

ORCID

0000-0002-5539-599X

ResearcherID

C-7705-2011

Scopus ID

55765694600

Research Interest Publications Projects Teaching Assignment RPG Supervision Space used

Research Interest

Cell biology
Cellular and molecular mechanisms
Intracellular protein trafficking
Membrane trafficking

Publications

All Years 47 2025 1 2024 5 2023 9 2022 4 2021 6 2020 4 2019 18

2025 1

Characterization of extracellular vesicles released from Prochlorococcus MED4 at the steady state and under a light–dark cycle

Philosophical Transactions of the Royal Society B: Biological Sciences, v. 380, (1918), January 2025 , article number 20230339
Peng, Ziqing; Liu, Yaxin; Ma, Haiying; Xiao, Shiwei; Au-Yeung, Allan; Zhang, Liang; Zeng, Qinglu; Guo, Yusong
Article

2024 5

High-Performance Gel-Free and Label-Free Size Fractionation of Extracellular Vesicles with Two-Dimensional Electrophoresis in a Microfluidic Artificial Sieve

Analytical Chemistry, v. 96, (8), February 2024, p. 3508-3516
Bu, Yang; Wang, Jinhui; Ni, Sheng; Lu, Zechen; Guo, Yusong; Yobas, Levent
Article

Identifications of novel host cell factors that interact with the receptor binding domain of the SARS-CoV-2 spike protein

Journal of biological chemistry, v. 300, (6), June 2024, article number 107390
Tang, Xiao; Liu, Yang; Wang, Jinhui; Long, Teng; Mok, Bobo Wing Yee; Huang, Yan; Peng, Ziqing; Jia, Qinyu; Liu, Chengxi; So, Pui-Kin; Tse, Sirius Pui-Kam; Ng, Cheuk Hei; Liu, Shiyi; Sun, Fei; Tang, Shaojun; Yao, Zhong-Ping; Chen, Honglin; Guo, Yusong
Article

Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes

Developmental Cell, October 2024
Zheng, Jun; Chen, Jing; Cao, Zhihe; Wu, Kaichen; Wang, Jinhui; Guo, Yusong; Zhuang, Min
Article

Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum

Developmental Cell, v. 59, (11), June 2024, p. 1396-1409.e5
Song, Yutong; Zhao, Zhihao; Xu, Linyu; Huang, Peiyuan; Gao, Jianyang; Li, Jingxuan; Wang, Xuejie; Zhou, Yiren; Wang, Jinhui; Zhao, Wenting; Wang, Likun; Zheng, Chaogu; Gao, Bo; Jiang, Liwen; Liu, Kai; Guo, Yusong; Yao, Xiaoqiang; Duan, Liting
Article

Conventional and Unconventional Protein Secretion in Yeast and Animal Cells

Plant Protein Secretion: Methods and Protocols / edited by Liwen Jiang, Jinbo Shen, Caiji Gao, Xiangfeng Wang. New York, NY : Humana, 2024, p. 1-17, Book series: Methods in Molecular Biology, v. 2841
Tang, Xiao; Guo, Yusong
Book chapter

2023 9

Continuous-flow label-free size fractionation of extracellular vesicles through electrothermal fluid rolls and dielectrophoresis synergistically integrated in a microfluidic device

Lab on a Chip, March 2023
Bu, Yang; Wang, Jinhui; Ni, Sheng; Guo, Yusong; Yobas, Levent
Article

In Vitro Reconstitution of COPII Vesicles from Arabidopsis Thaliana Suspension-Cultured Cells

Nature Protocols, v. 18, 4 January 2023, p. 810-830
Li, Baiying; Zeng, Yonglun; Lo, Sze Wan; Guo, Yusong; Jiang, Liwen
Article

Single-frame deep-learning super-resolution microscopy for intracellular dynamics imaging

Nature Communications, v. 14, (1), May 2023, article number 2854
Chen, Rong; Tang, Xiao; Zhao, Yuxuan; Shen, Zeyu; Zhang, Meng; Shen, Yusheng; Li, Tiantian; Chung, Casper Ho Yin; Zhang, Lijuan; Wang, Ji; Cui, Binbin; Fei, Peng; Guo, Yusong; Du, Shengwang; Yao, Shuhuai
Article

The clathrin adaptor complex-1 and Rab12 regulate post-golgi trafficking of WT epidermal growth factor receptor (EGFR)

Journal of Biological Chemistry, v. 299, (3), March 2023, article number 102979
Wang, Jinhui; Lau, Pik Ki; Li, Chun Wa; Guo, Yusong
Article

TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation

Proceedings of the National Academy of Sciences of the United States of America, v. 120, (46), November 2023, article number e2215285120
Li, Tiantian; Yang, Feng; Heng, Youshan; Zhou, Shaopu; Wang, Gang; Wang, Jianying; Wang, Jinhui; Chen, Xianwei; Yao, Zhong-Ping; Wu, Zhenguo; Guo, Yusong
Article

Reconstitution of Vesicle Budding from the TGN and Immunoisolation of Vesicles Enriched with a Specific Cargo Client

Golgi: Methods and Protocols / edited by Yanzhuang Wang, Vladimir V Lupashin, Todd R. Graham. New York, USA : Springer, 2023, p. 289-302, Book series: Methods in Molecular Biology, v. 2557
Wang, Mo; Wang, Jinhui; Guo, Yusong
Book chapter

Assembly of Printed Interconnects for Immobilized Protein Microfluidic Assays

24th European Microelectronics and Packaging Conference, EMPC 2023 / IEEE. Piscataway, NJ : IEEE, 2023, article number 10418280
Xu, Qianwen; Lee, Shi-wei; Guo, Yusong; Lo, Chi Chuen
Conference paper

Assembly of Printed Interconnects for Immobilized Protein Microfluidic Assays

Advancing Microelectronics, v. 2023, (EMPC), September 2023, p. 400-403
Xu, Qianwen; Lee, Shi-wei; Guo, Yusong; Lo, Chi Chuen
Conference paper

Continuous-Flow Size Fractionation of Submicron Particles and Extracellular Vesicles with Two-Dimensional Electrophoresis in an Artificial Sieving Array

Bu, Yang; Wang, Jinhui; Ni, Sheng; Lu, Zechen; Guo, Yusong; Yobas, Levent
Conference paper

2022 4

A SURF4-to-Proteoglycan Relay Mechanism that Mediates the Sorting and Secretion of a Tagged Variant of Sonic Hedgehog

Proceedings of the National Academy of Sciences of the United States of America, v. 119, (11), March 2022, article number e2113991119
Tang, Xiao; Chen, Rong; Mesias, Vince St. Dollente; Wang, Tingxuan; Wang, Ying; Poljak, Kristina; Fan, Xinyu; Miao, Hanchi; Hu, Junjie; Zhang, Liang; Huang, Jinqing; Yao, Shuhuai; Miller, Elizabeth A.; Guo, Yusong
Article

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, v. 10 , February 2022, article number 813353
Li, Tiantian; Guo, Yusong
Article

Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4

Journal of Biological Chemistry, v. 298, (12), December 2022, article number 102687
Tang, Xiao; Wang, Tingxuan; Guo, Yusong
Article

Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently

The Journal of Physical Chemistry Letters, v. 13, (45), November 2022, p. 10642-10648
Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Liu, Wei; Guo, Yusong; Huang, Jinqing
Article

2021 6

A distinct giant coat protein complex II vesicle population in Arabidopsis thaliana

Nature Plant, v. 7, (10), October 2021, p. 1335-1346
Li, Baiying; Zeng, Yonglun; Cao, Wenhan; Zhang, Wenxin; Cheng, Lixin; Yin, Haidi; Wu, Qian; Wang, Xiangfeng; Huang, Yan; Lau, Wilson Chun Yu; Yao, Zhong-Ping; Guo, Yusong; Jiang, Liwen
Article

An in vitro vesicle formation assay reveals cargo clients and factors that mediate vesicular trafficking

Proceedings of the National Academy of Sciences of the United States of America, v. 118, (35), August 2021, article number e2101287118
Huang, Yan; Yin, Haidi; Li, Baiying; Wu, Qian; Liu, Yang; Poljak, Kristina; Maldutyte, Julija; Tang, Xiao; Wang, Mo; Wu, Zhixiao; Miller, Elizabeth A.; Jiang, Liwen; Yao, Zhong-Ping; Guo, Yusong
Article

Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering

Chemical Communications, v. 57, (57), July 2021, p. 6979-6982
Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Guo, Yusong; Liu, Wei; Huang, Jinqing
Article

Endoplasmic Reticulum Composition And Form: Proteins In And Out

Current Opinion in Cell Biology, v. 71, August 2021, p. 1-6
Sun, Sha; Tang, Xiao; Guo, Yusong; Hu, Junjie
Article

Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation

Science Advances, v. 7, (20), May 2021, article number eabg2099
Feng, Di; Wang, Jin; Yang, Wei; Li, Jingyu; Lin, Xiaochen; Zha, Fangzi; Wang, Xiaolu; Ma, Luyao; Choi, Nga Ting; Mii, Yusuke; Takada, Shinji; Huen, Michael S. Y.; Guo, Yusong; Zhang, Liang; Gao, Bo
Article

Truncated Angiotensin-Converting Enzyme-2 peptide conjugated nanoparticles as an efficient, specific, and long-lasting antiviral platform for SARS-CoV-2

Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Guo, Yusong; Liu, Wei; Huang, Jinqing
Conference paper

2020 4

Cell-free Reconstitution of the Packaging of Cargo Proteins into Vesicles at the trans Golgi Network

Bio-protocol, v. 10, (5), March 2020, article number e3537
Tang, Xiao; Yang, Feng; Guo, Yusong
Article

Dynamically Tunable, Macroscopic Molecular Networks Enabled by Cellular Synthesis of 4-Arm Star-like Proteins

Matter, v. 2, (1), January 2020, p. 233-249
Yang, Zhongguang; Yang, Yang; Wang, Mo; Wang, Tingting; Fok, Hong Kiu Francis; Jiang, Bojing; Xiao, Wendi; Kou, Songzi; Guo, Yusong; Yan, Yan; Deng, Xin; Zhang, Wen-Bin; Sun, Fei
Article

Molecular Mechanisms That Regulate Export of the Planar Cell-Polarity Protein Frizzled-6 Out of the Endoplasmic Reticulum

Journal of Biological Chemistry, v. 295, (27), July 2020, p. 8972-8987
Tang, Xiao; Zhang, Lina; Ma, Tianji; Wang, Mo; Li, Baiying; Jiang, Liwen; Yan, Yan; Guo, Yusong
Article

The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations

Journal of Biological Chemistry, v. 295, (49), December 2020, p. 16643-16654
Yang, Feng; Li, Tiantian; Peng, Ziqing; Liu, Yang; Guo, Yusong
Article

2019 3

Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (28), June 2019, p. 14029-14038
Niu, Liling; Ma, Tianji; Yang, Feng; Yan, Bing; Tang, Xiao; Yin, Haidi; Wu, Qian; Huang, Yan; Yao, Zhong-Ping; Wang, Jifeng; Guo, Yusong; Hu, Junjie
Article

The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking

Development, v. 146, (13), June 2019, article number dev174615
Mao, Ying; Tu, Renjun; Huang, Yan; Mao, Decai; Yang, Zhihao; Lau, Pik Ki; Wang, Jinhui; Ni, Jianquan; Guo, Yusong; Xie, Ting
Article

Visualization of Protein Sorting at the Trans-Golgi Network and Endosomes Through Super-Resolution Imaging

Frontiers in Cell Development Biology, v. 7, September 2019, article number 181
Huang, Yan; Ma, Tianji; Lau, Pik Ki; Wang, Jinhui; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Guo, Yusong
Article

2018 2

A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network

Journal of Biological Chemistry, v. 293, (22), June 2018, p. 8410-8427
Ma, Tianji; Li, Baiying; Wang, Ryan; Lau, Pik Ki; Huang, Yan; Jiang, Liwen; Schekman, Randy; Guo, Yusong
Article

Intracellular trafficking of planar cell polarity proteins

Frontiers in Biology, v. 13, (6), December 2018, p. 395-405
Huang, Yan; Ma, Tianji; Guo, Yusong
Article

2017 1

An Overview of Protein Secretion in Yeast and Animal Cells

Plant Protein Secretion / New York, US : Humana Press, New York, NY, 2017, p. 1-17, Part of the Methods in Molecular Biology book series (MIMB, v. 1662)
Guo, Yusong; Yang, Feng; Tang, Xiao
Book chapter

2016 1

Statistical analysis and probabilistic verification of stress-induced signalling pathways

International Journal of Data Mining and Bioinformatics, v. 14, (2), February 2016, p. 120-138
Ma, Yinjiao; Feng, Lu; Guo, Yusong; Gong, Haijun
Article

2014 1

Protein Sorting at the trans-Golgi Network

Annual Review of Cell and Developmental Biology, v. 30, October 2014, p. 169-206
Guo, Yusong; Sirkis, Daniel W.; Schekman, Randy
Article

2013 2

A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network

eLife, v. 2013, (2), January 2013, article number e00160
Guo, Yusong; Zanetti, Giulia; Schekman, Randy W.
Article

Binding of the vesicle docking protein p115 to the GTPase Rab1b regulates membrane recruitment of the COPI vesicle coat

Cellular Logistics, v. 3, (1), January 2014, p. 1-10
Guo, Yusong; Linstedt, Adam D.
Article

2010 1

Discrete, continuous, and stochastic models of protein sorting in the Golgi apparatus

Physical Review E, v. 81, (1), January 2010, article number 011914
Gong, Haijun; Guo, Yusong; Linstedt, Adam; Schwartz, Russell
Article

2009 1

Active mask segmentation of fluorescence images

IEEE Transactions on Image Processing, v. 18, (8), August 2009, p. 1817-1829
Srinivasa, Gowri; Fickus, Matthew C.; Guo, Yusong; Linstedt, Adam D.; Kovačević, Jelena V.
Conference paper

2008 2

Coat-tether interaction in Golgi organization

v. 19, Issue 7, July 2008, p. 2830-2843
Guo, Yusong; Punj, Vasu; Sengupta, Debrup; Linstedt, Adam D.
Article

Active mask segmentation for the cell-volume computation and Golgi-body segmentation of hela cell images

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI\2008, Article number 4541004, Pages 348-351
Srinivasa, Gowri; Fickus, Matthew C.; Gonzalez-Rivero, Manuel N.; Hsieh, Sarah Yichia; Guo, Yusong; Linstedt, Adam D.; Kovačević, Jelena V.
Conference paper

2006 1

COPII-Golgi protein interactions regulate COPII coat assembly and Golgi size

Journal of Cell Biology, v. 174, Issue 1, 3 July 2006, p. 53-63
Guo, Yusong; Linstedt, Adam D.
Article

2004 2

A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice

Journal of Ethnopharmacology\ Volume 93, Issue 2-3, August 2004, Pages 325-330
Kong, Lingdong; Yang, Chen; Ge, Fei; Wang, Haidong; Guo, Yusong
Article

Antidepressant Evaluation of Polysaccharides from a Chinese Herbal Medicine Banxia-houpu Decoction

Phytotherapy Research, v. 18, (3), March 2004, p. 204-207
Guo, Yusong; Kong, Lingdong; Wang, Yemin; Huang, Zhiqi
Article

2002 1

Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice (in Chinese)

27(12): pp.939-941 & 944
Wang Hai-dong; Ge Fei; Guo Yusong; Kong, Ling-dong
Article

Article 1

Characterization of extracellular vesicles released from Prochlorococcus MED4 at the steady state and under a light–dark cycle

Philosophical Transactions of the Royal Society B: Biological Sciences, v. 380, (1918), January 2025 , article number 20230339
Peng, Ziqing; Liu, Yaxin; Ma, Haiying; Xiao, Shiwei; Au-Yeung, Allan; Zhang, Liang; Zeng, Qinglu; Guo, Yusong

Article 4

High-Performance Gel-Free and Label-Free Size Fractionation of Extracellular Vesicles with Two-Dimensional Electrophoresis in a Microfluidic Artificial Sieve

Analytical Chemistry, v. 96, (8), February 2024, p. 3508-3516
Bu, Yang; Wang, Jinhui; Ni, Sheng; Lu, Zechen; Guo, Yusong; Yobas, Levent

Identifications of novel host cell factors that interact with the receptor binding domain of the SARS-CoV-2 spike protein

Journal of biological chemistry, v. 300, (6), June 2024, article number 107390
Tang, Xiao; Liu, Yang; Wang, Jinhui; Long, Teng; Mok, Bobo Wing Yee; Huang, Yan; Peng, Ziqing; Jia, Qinyu; Liu, Chengxi; So, Pui-Kin; Tse, Sirius Pui-Kam; Ng, Cheuk Hei; Liu, Shiyi; Sun, Fei; Tang, Shaojun; Yao, Zhong-Ping; Chen, Honglin; Guo, Yusong

Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes

Developmental Cell, October 2024
Zheng, Jun; Chen, Jing; Cao, Zhihe; Wu, Kaichen; Wang, Jinhui; Guo, Yusong; Zhuang, Min

Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum

Developmental Cell, v. 59, (11), June 2024, p. 1396-1409.e5
Song, Yutong; Zhao, Zhihao; Xu, Linyu; Huang, Peiyuan; Gao, Jianyang; Li, Jingxuan; Wang, Xuejie; Zhou, Yiren; Wang, Jinhui; Zhao, Wenting; Wang, Likun; Zheng, Chaogu; Gao, Bo; Jiang, Liwen; Liu, Kai; Guo, Yusong; Yao, Xiaoqiang; Duan, Liting

Book chapter 1

Conventional and Unconventional Protein Secretion in Yeast and Animal Cells

Plant Protein Secretion: Methods and Protocols / edited by Liwen Jiang, Jinbo Shen, Caiji Gao, Xiangfeng Wang. New York, NY : Humana, 2024, p. 1-17, Book series: Methods in Molecular Biology, v. 2841
Tang, Xiao; Guo, Yusong

Article 5

Continuous-flow label-free size fractionation of extracellular vesicles through electrothermal fluid rolls and dielectrophoresis synergistically integrated in a microfluidic device

Lab on a Chip, March 2023
Bu, Yang; Wang, Jinhui; Ni, Sheng; Guo, Yusong; Yobas, Levent

In Vitro Reconstitution of COPII Vesicles from Arabidopsis Thaliana Suspension-Cultured Cells

Nature Protocols, v. 18, 4 January 2023, p. 810-830
Li, Baiying; Zeng, Yonglun; Lo, Sze Wan; Guo, Yusong; Jiang, Liwen

Single-frame deep-learning super-resolution microscopy for intracellular dynamics imaging

Nature Communications, v. 14, (1), May 2023, article number 2854
Chen, Rong; Tang, Xiao; Zhao, Yuxuan; Shen, Zeyu; Zhang, Meng; Shen, Yusheng; Li, Tiantian; Chung, Casper Ho Yin; Zhang, Lijuan; Wang, Ji; Cui, Binbin; Fei, Peng; Guo, Yusong; Du, Shengwang; Yao, Shuhuai

The clathrin adaptor complex-1 and Rab12 regulate post-golgi trafficking of WT epidermal growth factor receptor (EGFR)

Journal of Biological Chemistry, v. 299, (3), March 2023, article number 102979
Wang, Jinhui; Lau, Pik Ki; Li, Chun Wa; Guo, Yusong

TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation

Proceedings of the National Academy of Sciences of the United States of America, v. 120, (46), November 2023, article number e2215285120
Li, Tiantian; Yang, Feng; Heng, Youshan; Zhou, Shaopu; Wang, Gang; Wang, Jianying; Wang, Jinhui; Chen, Xianwei; Yao, Zhong-Ping; Wu, Zhenguo; Guo, Yusong

Book chapter 1

Reconstitution of Vesicle Budding from the TGN and Immunoisolation of Vesicles Enriched with a Specific Cargo Client

Golgi: Methods and Protocols / edited by Yanzhuang Wang, Vladimir V Lupashin, Todd R. Graham. New York, USA : Springer, 2023, p. 289-302, Book series: Methods in Molecular Biology, v. 2557
Wang, Mo; Wang, Jinhui; Guo, Yusong

Conference paper 3

Assembly of Printed Interconnects for Immobilized Protein Microfluidic Assays

24th European Microelectronics and Packaging Conference, EMPC 2023 / IEEE. Piscataway, NJ : IEEE, 2023, article number 10418280
Xu, Qianwen; Lee, Shi-wei; Guo, Yusong; Lo, Chi Chuen

Assembly of Printed Interconnects for Immobilized Protein Microfluidic Assays

Advancing Microelectronics, v. 2023, (EMPC), September 2023, p. 400-403
Xu, Qianwen; Lee, Shi-wei; Guo, Yusong; Lo, Chi Chuen

Continuous-Flow Size Fractionation of Submicron Particles and Extracellular Vesicles with Two-Dimensional Electrophoresis in an Artificial Sieving Array

Bu, Yang; Wang, Jinhui; Ni, Sheng; Lu, Zechen; Guo, Yusong; Yobas, Levent

Article 4

A SURF4-to-Proteoglycan Relay Mechanism that Mediates the Sorting and Secretion of a Tagged Variant of Sonic Hedgehog

Proceedings of the National Academy of Sciences of the United States of America, v. 119, (11), March 2022, article number e2113991119
Tang, Xiao; Chen, Rong; Mesias, Vince St. Dollente; Wang, Tingxuan; Wang, Ying; Poljak, Kristina; Fan, Xinyu; Miao, Hanchi; Hu, Junjie; Zhang, Liang; Huang, Jinqing; Yao, Shuhuai; Miller, Elizabeth A.; Guo, Yusong

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, v. 10 , February 2022, article number 813353
Li, Tiantian; Guo, Yusong

Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4

Journal of Biological Chemistry, v. 298, (12), December 2022, article number 102687
Tang, Xiao; Wang, Tingxuan; Guo, Yusong

Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently

The Journal of Physical Chemistry Letters, v. 13, (45), November 2022, p. 10642-10648
Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Liu, Wei; Guo, Yusong; Huang, Jinqing

Article 5

A distinct giant coat protein complex II vesicle population in Arabidopsis thaliana

Nature Plant, v. 7, (10), October 2021, p. 1335-1346
Li, Baiying; Zeng, Yonglun; Cao, Wenhan; Zhang, Wenxin; Cheng, Lixin; Yin, Haidi; Wu, Qian; Wang, Xiangfeng; Huang, Yan; Lau, Wilson Chun Yu; Yao, Zhong-Ping; Guo, Yusong; Jiang, Liwen

An in vitro vesicle formation assay reveals cargo clients and factors that mediate vesicular trafficking

Proceedings of the National Academy of Sciences of the United States of America, v. 118, (35), August 2021, article number e2101287118
Huang, Yan; Yin, Haidi; Li, Baiying; Wu, Qian; Liu, Yang; Poljak, Kristina; Maldutyte, Julija; Tang, Xiao; Wang, Mo; Wu, Zhixiao; Miller, Elizabeth A.; Jiang, Liwen; Yao, Zhong-Ping; Guo, Yusong

Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering

Chemical Communications, v. 57, (57), July 2021, p. 6979-6982
Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Guo, Yusong; Liu, Wei; Huang, Jinqing

Endoplasmic Reticulum Composition And Form: Proteins In And Out

Current Opinion in Cell Biology, v. 71, August 2021, p. 1-6
Sun, Sha; Tang, Xiao; Guo, Yusong; Hu, Junjie

Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation

Science Advances, v. 7, (20), May 2021, article number eabg2099
Feng, Di; Wang, Jin; Yang, Wei; Li, Jingyu; Lin, Xiaochen; Zha, Fangzi; Wang, Xiaolu; Ma, Luyao; Choi, Nga Ting; Mii, Yusuke; Takada, Shinji; Huen, Michael S. Y.; Guo, Yusong; Zhang, Liang; Gao, Bo

Conference paper 1

Truncated Angiotensin-Converting Enzyme-2 peptide conjugated nanoparticles as an efficient, specific, and long-lasting antiviral platform for SARS-CoV-2

Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Guo, Yusong; Liu, Wei; Huang, Jinqing

Article 4

Cell-free Reconstitution of the Packaging of Cargo Proteins into Vesicles at the trans Golgi Network

Bio-protocol, v. 10, (5), March 2020, article number e3537
Tang, Xiao; Yang, Feng; Guo, Yusong

Dynamically Tunable, Macroscopic Molecular Networks Enabled by Cellular Synthesis of 4-Arm Star-like Proteins

Matter, v. 2, (1), January 2020, p. 233-249
Yang, Zhongguang; Yang, Yang; Wang, Mo; Wang, Tingting; Fok, Hong Kiu Francis; Jiang, Bojing; Xiao, Wendi; Kou, Songzi; Guo, Yusong; Yan, Yan; Deng, Xin; Zhang, Wen-Bin; Sun, Fei

Molecular Mechanisms That Regulate Export of the Planar Cell-Polarity Protein Frizzled-6 Out of the Endoplasmic Reticulum

Journal of Biological Chemistry, v. 295, (27), July 2020, p. 8972-8987
Tang, Xiao; Zhang, Lina; Ma, Tianji; Wang, Mo; Li, Baiying; Jiang, Liwen; Yan, Yan; Guo, Yusong

The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations

Journal of Biological Chemistry, v. 295, (49), December 2020, p. 16643-16654
Yang, Feng; Li, Tiantian; Peng, Ziqing; Liu, Yang; Guo, Yusong

Article 3

Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (28), June 2019, p. 14029-14038
Niu, Liling; Ma, Tianji; Yang, Feng; Yan, Bing; Tang, Xiao; Yin, Haidi; Wu, Qian; Huang, Yan; Yao, Zhong-Ping; Wang, Jifeng; Guo, Yusong; Hu, Junjie

The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking

Development, v. 146, (13), June 2019, article number dev174615
Mao, Ying; Tu, Renjun; Huang, Yan; Mao, Decai; Yang, Zhihao; Lau, Pik Ki; Wang, Jinhui; Ni, Jianquan; Guo, Yusong; Xie, Ting

Visualization of Protein Sorting at the Trans-Golgi Network and Endosomes Through Super-Resolution Imaging

Frontiers in Cell Development Biology, v. 7, September 2019, article number 181
Huang, Yan; Ma, Tianji; Lau, Pik Ki; Wang, Jinhui; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Guo, Yusong

Article 2

A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network

Journal of Biological Chemistry, v. 293, (22), June 2018, p. 8410-8427
Ma, Tianji; Li, Baiying; Wang, Ryan; Lau, Pik Ki; Huang, Yan; Jiang, Liwen; Schekman, Randy; Guo, Yusong

Intracellular trafficking of planar cell polarity proteins

Frontiers in Biology, v. 13, (6), December 2018, p. 395-405
Huang, Yan; Ma, Tianji; Guo, Yusong

Book chapter 1

An Overview of Protein Secretion in Yeast and Animal Cells

Plant Protein Secretion / New York, US : Humana Press, New York, NY, 2017, p. 1-17, Part of the Methods in Molecular Biology book series (MIMB, v. 1662)
Guo, Yusong; Yang, Feng; Tang, Xiao

Article 1

Statistical analysis and probabilistic verification of stress-induced signalling pathways

International Journal of Data Mining and Bioinformatics, v. 14, (2), February 2016, p. 120-138
Ma, Yinjiao; Feng, Lu; Guo, Yusong; Gong, Haijun

Article 1

Protein Sorting at the trans-Golgi Network

Annual Review of Cell and Developmental Biology, v. 30, October 2014, p. 169-206
Guo, Yusong; Sirkis, Daniel W.; Schekman, Randy

Article 2

A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network

eLife, v. 2013, (2), January 2013, article number e00160
Guo, Yusong; Zanetti, Giulia; Schekman, Randy W.

Binding of the vesicle docking protein p115 to the GTPase Rab1b regulates membrane recruitment of the COPI vesicle coat

Cellular Logistics, v. 3, (1), January 2014, p. 1-10
Guo, Yusong; Linstedt, Adam D.

Article 1

Discrete, continuous, and stochastic models of protein sorting in the Golgi apparatus

Physical Review E, v. 81, (1), January 2010, article number 011914
Gong, Haijun; Guo, Yusong; Linstedt, Adam; Schwartz, Russell

Conference paper 1

Active mask segmentation of fluorescence images

IEEE Transactions on Image Processing, v. 18, (8), August 2009, p. 1817-1829
Srinivasa, Gowri; Fickus, Matthew C.; Guo, Yusong; Linstedt, Adam D.; Kovačević, Jelena V.

Article 1

Coat-tether interaction in Golgi organization

v. 19, Issue 7, July 2008, p. 2830-2843
Guo, Yusong; Punj, Vasu; Sengupta, Debrup; Linstedt, Adam D.

Conference paper 1

Active mask segmentation for the cell-volume computation and Golgi-body segmentation of hela cell images

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI\2008, Article number 4541004, Pages 348-351
Srinivasa, Gowri; Fickus, Matthew C.; Gonzalez-Rivero, Manuel N.; Hsieh, Sarah Yichia; Guo, Yusong; Linstedt, Adam D.; Kovačević, Jelena V.

Article 1

COPII-Golgi protein interactions regulate COPII coat assembly and Golgi size

Journal of Cell Biology, v. 174, Issue 1, 3 July 2006, p. 53-63
Guo, Yusong; Linstedt, Adam D.

Article 2

A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice

Journal of Ethnopharmacology\ Volume 93, Issue 2-3, August 2004, Pages 325-330
Kong, Lingdong; Yang, Chen; Ge, Fei; Wang, Haidong; Guo, Yusong

Antidepressant Evaluation of Polysaccharides from a Chinese Herbal Medicine Banxia-houpu Decoction

Phytotherapy Research, v. 18, (3), March 2004, p. 204-207
Guo, Yusong; Kong, Lingdong; Wang, Yemin; Huang, Zhiqi

Article 1

Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice (in Chinese)

27(12): pp.939-941 & 944
Wang Hai-dong; Ge Fei; Guo Yusong; Kong, Ling-dong

2019 3

Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (28), June 2019, p. 14029-14038
Niu, Liling; Ma, Tianji; Yang, Feng; Yan, Bing; Tang, Xiao; Yin, Haidi; Wu, Qian; Huang, Yan; Yao, Zhong-Ping; Wang, Jifeng; Guo, Yusong; Hu, Junjie
Article

The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking

Development, v. 146, (13), June 2019, article number dev174615
Mao, Ying; Tu, Renjun; Huang, Yan; Mao, Decai; Yang, Zhihao; Lau, Pik Ki; Wang, Jinhui; Ni, Jianquan; Guo, Yusong; Xie, Ting
Article

Visualization of Protein Sorting at the Trans-Golgi Network and Endosomes Through Super-Resolution Imaging

Frontiers in Cell Development Biology, v. 7, September 2019, article number 181
Huang, Yan; Ma, Tianji; Lau, Pik Ki; Wang, Jinhui; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Guo, Yusong
Article

2018 2

A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network

Journal of Biological Chemistry, v. 293, (22), June 2018, p. 8410-8427
Ma, Tianji; Li, Baiying; Wang, Ryan; Lau, Pik Ki; Huang, Yan; Jiang, Liwen; Schekman, Randy; Guo, Yusong
Article

Intracellular trafficking of planar cell polarity proteins

Frontiers in Biology, v. 13, (6), December 2018, p. 395-405
Huang, Yan; Ma, Tianji; Guo, Yusong
Article

2017 1

An Overview of Protein Secretion in Yeast and Animal Cells

Plant Protein Secretion / New York, US : Humana Press, New York, NY, 2017, p. 1-17, Part of the Methods in Molecular Biology book series (MIMB, v. 1662)
Guo, Yusong; Yang, Feng; Tang, Xiao
Book chapter

2016 1

Statistical analysis and probabilistic verification of stress-induced signalling pathways

International Journal of Data Mining and Bioinformatics, v. 14, (2), February 2016, p. 120-138
Ma, Yinjiao; Feng, Lu; Guo, Yusong; Gong, Haijun
Article

2014 1

Protein Sorting at the trans-Golgi Network

Annual Review of Cell and Developmental Biology, v. 30, October 2014, p. 169-206
Guo, Yusong; Sirkis, Daniel W.; Schekman, Randy
Article

2013 2

A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network

eLife, v. 2013, (2), January 2013, article number e00160
Guo, Yusong; Zanetti, Giulia; Schekman, Randy W.
Article

Binding of the vesicle docking protein p115 to the GTPase Rab1b regulates membrane recruitment of the COPI vesicle coat

Cellular Logistics, v. 3, (1), January 2014, p. 1-10
Guo, Yusong; Linstedt, Adam D.
Article

2010 1

Discrete, continuous, and stochastic models of protein sorting in the Golgi apparatus

Physical Review E, v. 81, (1), January 2010, article number 011914
Gong, Haijun; Guo, Yusong; Linstedt, Adam; Schwartz, Russell
Article

2009 1

Active mask segmentation of fluorescence images

IEEE Transactions on Image Processing, v. 18, (8), August 2009, p. 1817-1829
Srinivasa, Gowri; Fickus, Matthew C.; Guo, Yusong; Linstedt, Adam D.; Kovačević, Jelena V.
Conference paper

2008 2

Coat-tether interaction in Golgi organization

v. 19, Issue 7, July 2008, p. 2830-2843
Guo, Yusong; Punj, Vasu; Sengupta, Debrup; Linstedt, Adam D.
Article

Active mask segmentation for the cell-volume computation and Golgi-body segmentation of hela cell images

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI\2008, Article number 4541004, Pages 348-351
Srinivasa, Gowri; Fickus, Matthew C.; Gonzalez-Rivero, Manuel N.; Hsieh, Sarah Yichia; Guo, Yusong; Linstedt, Adam D.; Kovačević, Jelena V.
Conference paper

2006 1

COPII-Golgi protein interactions regulate COPII coat assembly and Golgi size

Journal of Cell Biology, v. 174, Issue 1, 3 July 2006, p. 53-63
Guo, Yusong; Linstedt, Adam D.
Article

2004 2

A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice

Journal of Ethnopharmacology\ Volume 93, Issue 2-3, August 2004, Pages 325-330
Kong, Lingdong; Yang, Chen; Ge, Fei; Wang, Haidong; Guo, Yusong
Article

Antidepressant Evaluation of Polysaccharides from a Chinese Herbal Medicine Banxia-houpu Decoction

Phytotherapy Research, v. 18, (3), March 2004, p. 204-207
Guo, Yusong; Kong, Lingdong; Wang, Yemin; Huang, Zhiqi
Article

2002 1

Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice (in Chinese)

27(12): pp.939-941 & 944
Wang Hai-dong; Ge Fei; Guo Yusong; Kong, Ling-dong
Article

Teaching Assignment

2024-25 Spring 4 2024-25 Winter 0 2024-25 Fall 8 2023-24 Summer 1 2023-24 Spring 8 2023-24 Winter 0

LIFS2040	Cell Biology
LIFS6117H	Current Topics in Cell Biology
SCIE2500	Guided Study on Research II
UROP1100O	Undergraduate Research Opportunities Series 1

ENVS5111	Environmental Health
LIFS4910A	Independent Study
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4971	Biochemistry and Cell Biology Project Research I
LIFS5710	Cellular Regulation
LIFS6170	Special Topics in Molecular, Cell and Developmental Biology
SCIE3500	IRE Research Project I
SCIE4500	IRE Research Project II

UROP1100M

Undergraduate Research Opportunities Series 1

BIBU4840	Biotechnology and Business Capstone Project
LIFS2040	Cell Biology
LIFS4910A	Independent Study
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4963	Biotechnology Capstone Project
LIFS4981	Biochemistry and Cell Biology Project Research II
LIFS6117G	Current Topics in Cell Biology
SCIE2500	Guided Study on Research II

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 15 May 2025)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

CONG, Chengge
Life Science
LU, Zechen
Life Science
WANG, Tingxuan
Life Science
LI, Anqi
Life Science
QU, Rui
Life Science
XU, Qianwen (co-supervision)
Individualized Interdisciplinary Program (Smart Manufacturing)
TRINH, Thi Huong
Life Science
XU, Yingjie
Life Science
LIU, Yang
Life Science
HASSAN, Shaoli
Life Science

Master of Philosophy

AN, Junkun
Life Science
ZHANG, Zhiting
Life Science
LI, Chun Wa
Life Science
ZHOU, Peizhi
Life Science

Graduated RPGs

Doctor of Philosophy

LI, Tiantian
Life Science( Completed in 2024 )
PENG, Ziqing
Life Science( Completed in 2024 )
JIA, Bowen
Life Science( Completed in 2023 )
WANG, Mo
Life Science( Completed in 2023 )
WANG, Jinhui
Life Science( Completed in 2022 )

Master of Philosophy

CONG, Chengge
Life Science( Completed in 2024 )
LU, Zechen
Life Science( Completed in 2024 )
LUI, Sze Wai
Life Science( Completed in 2024 )
LI, Yihao (co-supervision)
Individualized Interdisciplinary Program (Bioscience and Biomedical Engineering)( Completed in 2023 )
WANG, Tingxuan
Life Science( Completed in 2023 )

Projects

From January 2023 to December 2025

All Projects 13 Leading Projects 9 Participating Projects 4

Investigating the roles of VTI1B and SCAMP2 in post-Golgi trafficking of Frizzled6 for establishing planar cell polarity

研究VTI1B和SCAMP2在Frizzled6後高爾基體運輸過程中的作用及其對平面細胞極性的建立的影響 Leading

RGC - General Research Fund
Project Team (HKUST)
GUO Yusong (Lead)
2025 -
Molecular Mechanisms of Vacuole Biogenesis and Vacuole Fission in Plants

植物液泡生物發生和液泡裂變的分子機制 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
GUO Yusong
2024 -
Investigating adaptor protein complex-4 (AP-4)-mediated protein sorting at the trans Golgi network

探索貨物蛋白適配器複合體-4在反式高爾基網上所進行的貨物蛋白篩選的分子機制 Leading

RGC - General Research Fund
Project Team (HKUST)
GUO Yusong (Lead)
2024 -
Membrane Trafficking: from Molecular Mechanisms to Therapeutic Applications Leading

K. C. Wong Education Foundation
Project Team (HKUST)
GUO Yusong (Lead)
2024 - 2024
Mechanistic study of the defense systems in marine cyanobacteria against bacteriophage infection

海洋藍藻的抗病毒侵染機制 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
ZENG Qinglu (Lead)

DANG Shangyu

GUO Yusong

WANG Jiguang
2023 -
Roles of PRRC1 and FAM84B in COPII-mediated endoplasmic reticulum export

PRRC1和FAM84B在COPII介導的內質網輸出中的功能 Leading

RGC - General Research Fund
Project Team (HKUST)
GUO Yusong (Lead)
2023 -
Stem cell-niche interactions in tissue maintenance and engineering

幹細胞與微環境互作在組織維持和組織工程中的應用 Participating

RGC - Theme-based Research Scheme
Project Team (HKUST)
XIE Ting (Lead)

CHEUNG Tom

GUO Yusong

LEUNG Danny Chi Yeu

LIU Kai

MAK Ho Yi

SUN Fei

WU Angela Ruohao

WU Zhenguo

YAN Yan
2022 -
Molecular mechanisms regulating the sorting and secretion of sonic hedgehog

探索調控細胞分泌刺猬因子的分子機制 Leading

RGC - General Research Fund
Project Team (HKUST)
GUO Yusong (Lead)
2021 - 2024
Molecular Mechanisms Regulating transport of a planar cell polarity protein, Frizzled6, in the early secretory transport pathway

平面細胞極化蛋白Frizzled6在早期分泌轉運途中運輸的分子機制 Leading

National Natural Science Foundation of China
Project Team (HKUST)
GUO Yusong (Lead)
2021 - 2024
Vacuole Dynamics, Biogenesis and Functions in Plants

植物液泡的動力學，生物起源與功能的研究 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
GUO Yusong
2021 - 2024
Molecular Mechanisms Regulating the Secretion of Insulin-Like Growth Factor 2 in Myoblast Differentiation and Muscle Regeneration

探索調節胰島素樣生長因子2分泌的分子機制及其在成肌細胞分化和肌肉再生中的功能 Leading

RGC - General Research Fund
Project Team (HKUST)
GUO Yusong (Lead)
2021 - 2023
Activity regulated neuroligin-2 ubiquitination and inhibitory synapse formation.

神經活動調控neuroligin-2泛素化和抑制性突觸形成 Leading

RGC - General Research Fund
Project Team (HKUST)
GUO Yusong (Lead)
2020 - 2024
CDK5RAP2 Autoinhibition as a Control Mechanism of γTuRC-Dependent Microtubule Organization

CDK5RAP2自抑制對依賴於γ-微管蛋白環形複合體的微管組織的調控 Leading

RGC - General Research Fund
Project Team (HKUST)
GUO Yusong (Lead)
2020 - 2024

Research Interest

Publications

2025 1

2024 5

2023 9

2022 4

2021 6

2020 4

2019 3

2018 2

2017 1

2016 1

2014 1

2013 2

2010 1

2009 1

2008 2

2006 1

2004 2

2002 1

Article 1

Article 4

Book chapter 1

Article 5

Book chapter 1

Conference paper 3

Article 4

Article 5

Conference paper 1

Article 4

Article 3

Article 2

Book chapter 1

Article 1

Article 1

Article 2

Article 1

Conference paper 1

Article 1

Conference paper 1

Article 1

Article 2

Article 1

2019 3

2018 2

2017 1

2016 1

2014 1

2013 2

2010 1

2009 1

2008 2

2006 1

2004 2

2002 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 15 May 2025)

Current RPGs

Graduated RPGs

Projects

From January 2023 to December 2025

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