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Yung Hou WONG
王殷厚

PhD in Pharmacology
University of Cambridge, 1989

Dean of Science

Chair Professor
Division of Life Science

Director of Molecular Neuroscience Center

Program Director of MSc in Biotechnology

Associate Director of Biotechnology Research Institute

Associate Director of Center for Aging Science

  • (852) 2358 7328
  • boyung@ust.hk
  • Room 6520
  • Personal Web

Google Scholar
KjIw9kUAAAAJ
ORCID
0000-0002-0123-7697
Scopus ID
35263245300
Research Interest Publications Projects Teaching Assignment RPG Supervision Space used

Research Interest


  • Cell signaling

Publications


All Years 374 2023 0 2022 1 2021 6 2020 5 2019 5 2018 3 2017 354

2022 1

Reconstructing Gαi1 into an effector-deficient mutant for the detection of receptor-activated Gβγ signals


Chan, Ho Yung; Wong, Yung Hou
Conference paper
2021 6

CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1

Scientific Reports, v. 11, (1), January 2021, article number 491
Wong, Ka Ming; Song, Jiaxing; Wong, Yung Hou
Article

Modeling The Heterodimer Interfaces Of Melatonin Receptors

Frontiers in Cellular Neuroscience, v.15, 7 October 2021, article number 725296, p. 356-356
Tse, Lap Hang; Wong, Yung Hou
Article

Re-examining the ‘Dissociation Model’ of G protein activation from the perspective of Gβγ signaling

FEBS Journal, v. 288, (8), April 2021, p. 2490-2501
Chung, Yin Kwan; Wong, Yung Hou
Article

Allosteric modulations in signal transduction of the melatonin receptor heterodimer MT1/MT2


Tse, Lap Hang; Wong, Yung Hou
Conference paper

Nm23-H1 alters exosome content to abrogate pro-metastatic effect of breast cancer cell derived exosomes


Saini, Vasu; Wong, Yung Hou
Conference paper

Transcriptional targets of Nm23-H1 alter its metastasis suppressor function


Song, Jiaxing; Xie, Jia; Wong, Yung Hou
Conference paper
2020 5

Age Associated Decrease of MT-1 Melatonin Receptor in Human Dermal Skin Fibroblasts Impairs Protection Against UV-Induced DNA Damage

International Journal of Molecular Sciences, v. 21, (1), January 2020, article number 326
Dong, Kelly; Goyarts, Earl; Rella, Antonella; Pelle, Edward; Wong, Yung Hou; Pernodet, Nadine
Article

AGS3 and Gαi3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells

Molecules (Basel, Switzerland), v. 25, (21), November 2020, article number 5169
Yip, Leung Kwan; Lee, Maggie M. K.; Leung, Crystal C. Y.; Tse, Man Kit; Cheung, Suet Ting; Wong, Yung Hou
Article

Molecular basis defining the selectivity of substituted isoquinolinones for the melatonin MT2 receptor

Biochemical Pharmacology, v. 177, July 2020, article number 114020
Chan, King Hang; Tse, Lap Hang; Huang, Xuhui; Wong, Yung Hou
Article

Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function

Molecular and Cellular Biochemistry, v. 474, (1-2), November 2020, p. 95-112
Li, Yuanjun; Liu, Wen; Saini, Vasu; Wong, Yung Hou
Article

Anti-migratory effect of Nm23-H1 via exosomes


Saini, Vasu; Wong, Yung Hou; Sun, Siu Nam
Conference paper
2019 5

GPCRs in Autocrine and Paracrine Regulations

Frontiers in Endocrinology, v. 10, (JULY), July 2019, article number 428
Tse, Lap Hang; Wong, Yung Hou
Article

Small molecules as drugs to upregulate metastasis suppressors in cancer cells

Current Medicinal Chemistry, v. 26, (32), November 2019, p. 5876-5899
Wong, Ka Ming; Song, Jiaxing; Saini, Vasu; Wong, Yung Hou
Article

Generation of an effector-deficient Gαi1


Chung, Yin Kwan; Wong, Yung Hou
Conference paper

The role of leukemia inhibitory factor (LIF) in the intercellular communication between neurons and astrocytes. Abstract P48.


Gu, Yishan; Wong, Yung Hou
Conference paper

Unraveling the mechanism of RGS-induced upregulation of Nm23-H1. Abstract P68


Song, Jiaxing; Wong, Yung Hou
Conference paper
2018 3

MT1 and MT2 melatonin receptors: heteromerization and functional significance


Tse, Lap Hang; Wong, Yung Hou
Conference paper

Non-dissociable Gβ-Gα fusion proteins reveal different mechanisms of G protein activation


Liu, Wen; Wong, Ka Ming; Chan, Siu Lung Anthony; Wong, Yung Hou
Conference paper

Regulation of metastasis suppressor genes mediated by breast cancer derived exosomes


Saini, Vasu; Wong, Yung Hou
Conference paper
2017 8

RGS19 Upregulates Nm23-H1/2 Metastasis Suppressors by Transcriptional Activation via the cAMP/PKA/CREB Pathway

Oncotarget, v. 8, (41), July 2017, p. 69945-69960
Li, Yuanjun; Song, Jiaxing; Tong, Yao; Chung, Sookjakim; Wong, Yung Hou
Article

Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function

Molecules, v. 22, (7), July 2017, article number 1239
Leung, Ching Yiu Crystal; Wong, Yung Hou
Article

Activation of PKA-dependent transcription factors by RGS19 upregulates metastasis suppressor Nm23-H1/2.


Song, Jiaxing; Wong, Yung Hou
Conference paper

Back to the basics: the G protein cycle


Wong, Yung Hou; Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming
Conference paper

Differential G protein subunit dissociation mechanisms suggest possible family-wise selective Gβγ signaling


Liu, Wen; Li, Jiayue; Zhou, Longyin; Wong, Yung Hou
Conference paper

Functional characterization of heteromerization effects of melatonin receptors


Tse, Lap Hang; Ng, Siu Wang; Chan, King Hang; Wong, Yung Hou
Conference paper

Gq signaling pathway of melatonin receptor in islets of Langerhans


Gu, Yishan; Chan, Sze Man; Wong, Yung Hou
Conference paper

Transcriptional and post-transcriptional regulation of NME1 in cancer metastasis.


Wong, Yung Hou; Wong, Ka Ming
Conference paper
2016 9

Anxiety and Depression with Neurogenesis Defects in Exchange Protein Directly Activated by cAMP 2-Deficient Mice are Ameliorated by a Selective Serotonin Reuptake Inhibitor, Prozac

Translational Psychiatry, v. 6, (9), September 2016, article number e881
Zhou, L.; Ma, Sukling; Yeung, Patrick Ka Kit; Wong, Yung Hou; Tsim, Karl Wah Keung; So, K. F.; Lam, L.C.W.; Chung, S.K.
Article

Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by Gi- and Gq-Regulated Pathways

Journal of Molecular Biology, v. 428, (19), September 2016, p. 3869-3884
Chan, Anthony Siu Lung; Lau, Wai In; Szeto, Aydan C.H.; Wang, Jiuling; Wong, Yunghou
Article

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai
Article

Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species

Pharmaceutica Analytica Acta, v. 7, (4), April 2016, article number 1000474
Bi, Dan; Zhang, L.M.L.; Tang, Wai Lun; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Wong, Yung Hou; Lin, Huangquan; Tsim, Karl Wah Keung
Article

Regulator of G Protein Signaling 20 Enhances Cancer Cell Aggregation, Migration, Invasion and Adhesion

Cellular Signalling, v. 28, (11), November 2016, p. 1663-1672
Yang, Lei; Lee, Mei Ki; Leung, Man Hon Manton; Wong, Yung Hou
Article

Cdk5 Activity is Required for EphB-mediated Synaptogenesis


Chen, Yu; Wong, Yung Hou; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Conference paper

Flavonoids Induce the Expression of Acetylcholinesterase in Cultured Osteoblasts

Chemico-Biological Interactions, v. 259, (B), 25 November 2016, p. 295-300
Xu, Miranda Li; Bi, Wenchuan; Kong, Yeung Yeung Ava; Dong, Ting Xia; Wong, Yung Hou; Tsim, Karl Wah Keung
Conference paper

Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes


Wu, Y.; Chan, K.H.; Wong, Yung Hou
Conference paper

The role of RGS20 in cell cycle regulation and angiogenesis


Leung, M.; Alim, A.S.; Xu, R.; Wong, Yung Hou
Conference paper
2015 15

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gαi3

Molecular and Cellular Biochemistry, v. 401, (1-2), March 2015, p. 27-38
Tse, Man Kit; Morris, Christina Jane; Zhang, Mingjie; Wong, Yung Hou
Article

An intact helical domain is required for Gα14 to stimulate phospholipase Cβ

BMC Structural Biology, v. 15, (1), September 2015, article number 18
Kwan, Dawna HT; Wong, Ka Ming; Chan, Anthony Siu Lung; Yung, Lisa Ying; Wong, Yung Hou
Article

Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ

BMC Cancer, v. 15, (1), October 2015, article number 775
Zuo, Hao; Wong, Yung Hou
Article

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai
Article

Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis

Cancer Letters, v. 361, (2), June 2015, p. 207-217
Tong, Yao; Yung, Lisa Ying; Wong, Yung Hou
Article

Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives

Naunyn-Schmiedeberg's Archives of Pharmacology, v. 388, (2), February 2015, p. 243-256
Li, Yuanjun; Tong, Yao; Wong, Yung Hou
Article

RAS Genes

Encyclopedia of Cancer: a Springer Live Reference /Edited by Manfred Schwab. Berlin, Heidelberg : Springer, 2015, p. 1-6
Wong, Yung Hou; Pellicer, Angel; Liu, Wen
Book chapter

Activation Of Phospholipase Cβ By NonDissociable Gq Proteins


Wong, Yung Hou; Liu, W.; Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, K.M.
Conference paper

Functional characterization of type 2 diabetes associated MTNRIB variants


Wu, Y.; Chan, K.H.; Wong, Yung Hou
Conference paper

Inhibition of oncogenic Ras-induced tumorigenesis by Nm23 metastasis suppressors


Wong, Y.H.; Li, Y.
Conference paper

Involvement of G proteins in asymmetric cell division during neurogenesis


Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou
Conference paper

Molecular determinants of selective ligand binding at the human melatonin receptor


Chan, King Hang; Wong, Yung Hou
Conference paper

Non-dissociable Gβ-Gα Fusion Proteins Reveal Different Mechanisms Of G Protein Activation


Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming; Wong, Yung Hou
Conference paper

Post-transcriptional regulation of the regulator of G protein signaling 19 (RGS19) and metastasis suppressor Nm23 in cancer by microRNAs


Wong, Ka Ming; Wong, Yung Hou
Conference paper

Role of surface residues on defining the functional specificity of Nm23 metastasis suppressors


Li, Yuanjun; Wong, Yung Hou
Conference paper
2014 11

Angiotensin-[1-12] interacts with angiotensin type I receptors

Neuropharmacology, v. 81, June 2014, p. 267-273
Chan, King Hang; Chen, Yi Hung; Zhang, Ying; Wong, Yung Hou; Dun, Nae J.
Article

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

NeuroSignals, v. 22, (1), May 2014, p. 52-63
Ip, Fanny Chui Fun; Ng, Yu Pong; An, Hui Jin; Dai, Ying; Pang, Hai Hong; Hu, Yue Qing; Chin, Allison C.; Harley, Calvin B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Article

Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways

Neuroscience, v. 267, May 2014, p. 241-251
Tse, Kai Hei; Chow, K.B.S.; Leung, W.K.; Wong, Yung Hou; Wise, H.
Article

Primary Sensory Neurons Regulate Toll-like receptor-4-dependent Activity of Glial Cells in Dorsal Root Ganglia

Neuroscience, v. 279, October 2014, p. 10-22
Tse, Kai-Hei; Chow, K.B.S.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Article

Synthesis and Functional Characterization of Substituted Isoquinolinones as MT2-Selective Melatoninergic Ligands

PLoS ONE, v. 9, (12), December 2014, article number 0113638
Hu, Yueqing; Chan, King Hang; He, Xixin; Ho, Maurice Kwok Chung; Wong, Yung Hou
Article

Activation of Gq without Subunits Dissociation


Liu, Wen; Wong, Yung Hou
Conference paper

Activation of PLCβ by a Non-dissociable Gq Protein


Liu, W.; Chan, Siu Lung Anthony; Wong, K.M.; Wong, Yung Hou
Conference paper

ENStem - A Cells as a Model for Studying Neurogenesis


Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou
Conference paper

Multi-faceted Metastasis Suppressor Nm23 is Up-regulated by RGS19 via Activating Transcription Factors


Li, Y.; Wong, Yung Hou
Conference paper

RGS19 Up-regulates Nm23-H1/2 Expression via Stimulating Multiple Transcriptional Factors


Li, Yuanjun; Wong, Yung Hou
Conference paper

RGS20 as a Modulator of Tumorigenesis and Angiogenesis


Leung, Man Hon Manton; Yang, Lei; Wong, Yung Hou
Conference paper
2013 17

A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity

International Journal of Molecular Sciences, v. 14, (9), September 2013, p. 18385-18406
Chan, King Hang; Wong, Yung Hou
Article

Activation of Gαq subunits up-regulates the expression of the tumor suppressor Fhit

Cellular Signalling, v. 25, (12), December 2013, p. 2440-2452
Zuo, Hao; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou
Article

Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor

Cell Communication and Signaling, v. 11, (1), August 2013, article number 59
Zuo, Hao; Chan, Grace P.W.; Zhu, Jing; Yeung, Wendy Wing Shan; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou
Article

Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor

Current Medicinal Chemistry, v. 20, (2), January 2013, p. 289-300
Chan, King Hang; Hu, Sharry Y.; Ho, Maurice K C; Wong, Yung Hou
Article

Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT2-selective melatonin agonists: Improving metabolic stability

Bioorganic and Medicinal Chemistry, v. 21, (2), January 2013, p. 547-552
Hu, Yueqing; Zhu, Jing; Chan, King Hang; Wong, Yung Hou
Article

Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms

Cell Communication and Signaling, v. 11, (1), April 2013, article number 22
Lau, Winnie Wai In; Chan, Anthony Siu Lung; Poon, Lydia See Wing; Zhu, Jing; Wong, Yung Hou
Article

Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells

British Journal of Pharmacology, v. 168, (3), February 2013, p. 746-760
Ng, Kai Yu; Yeung, Barry Ho Sing; Wong, Yung Hou; Wise, Helen
Article

Neuronal Functions of Activators of G Protein Signaling

NeuroSignals, v. 21, (3-4), May 2013, p. 259-271
Tse, Man Kit; Wong, Yung Hou
Article

Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis

Cancer Letters, v. 339, (1), October 2013, p. 33-41
Wang, Yingchun; Tong, Yao; Tso, Prudence H.; Wong, Yung Hou
Article

RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras

Cellular Signalling, v. 25, (5), May 2013, p. 1064-1074
Tso, Ha Prudence; Wang, Yingchun; Yung, Ying Lisa; Tong, Yao; Lee, Mei Ki Maggie; Wong, Yung Hou
Article

Development of novel melatoninergics as circadian rhythm sleep disorder therapeutics

New Developments in Melatonin Research / Editors: Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames. Nova Science Publishers, Inc., 2013, p. 53-76
Chan, King Hang; Cheung, Annie Suet Ting; Ho, Maurice K.C.; Wong, Yung Hou
Book chapter

High-throughput screening in traditional Chinese medicine-based drug discovery

Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds / Editors: Evandro Fei Fang, Tzi Bun Ng. Dordrecht : Springer Science+Business Media, 2013, p. 387-404
Wong, Catherine Chi Kit; Wong, Yung Hou
Book chapter

Nm23 Mediates RGS19-induced Suppression of Ras Signaling


Wong, Yung Hou
Conference paper

Regulation of STAT3 by GPCRs Involves Interleukin-6 Autocrine Signaling


Wong, Yung Hou
Conference paper

Sensory Neurons Regulate Toll-like Receptor 4 (TLR4) Signaling in Glia Derived from Dorsal Root Ganglia (DRG)


Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Conference paper

Toll-like Receptor 4 (TLR4) Differentially Regulates Cox-1 and Cox-2 to Enhance Prostanoid Production by Primary Sensory Neurons


Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Conference paper

Toll-like Receptor 4 (TLR4) Increases Expression of Inflammatory Mediators in Primary Sensory Neurons via Activation of a MyD88-dependent Signaling Pathway

Acta Pharmacologica Sinica, v. 34, July 2013, p. 116
Wise, Helen; Chow, Kevin Bing Shui; Tse, Kai Hei; Leung, Wai Keung; Wong, Yung Hou
Conference paper
2012 11

Activation of ras-dependent signaling pathways by G14-coupled receptors requires the adaptor protein TPR1

Journal of Cellular Biochemistry, v. 113, (11), November 2012, p. 3486-3497
Kwan, Dawna H.T.; Yung, Lisa Y.; Ye, Richard D.; Wong, Yung Hou
Article

Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types

Planta Medica, v. 78, (2), January 2012, p. 115-121
Yung, Ying Lisa; Lam, Wing See; Ho, Maurice K.C.; Hu, Sharry Y.; Ip, Fanny C.F.; Pang, Haihong; Chin, Allison; Harley, Calvin B.; Ip, Nancy Yuk-yu; Wong, Yung Hou
Article

CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα14/16 Signaling and IL-6 Release

Journal of Immunology, v. 189, (11), December 2012, p. 5266-5276
Lee, Mei Ki; Chui, Ricky K.S.; Tam, Issan Y.S.; Lau, Alaster H.Y.; Wong, Yung Hou
Article

Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum

Molecular and Cellular Biochemistry, v. 362, (1-2), March 2012, p. 159-168
Ip, Angel K.C.; Tso, Ha; Lee, Mei Ki; Wong, Yung Hou
Article

Interleukin-6 autocrine signaling mediates melatonin MT1/2 receptor-induced STAT3 Tyr705 phosphorylation

Journal of Pineal Research, v. 52, (4), May 2012, p. 477-489
Lau, Wai In; Ng, Johnson K.Y.; Lee, Mei Ki; Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats

Xenobiotica, v. 42, (11), November 2012, p. 1138-1150
Zhu, Jing; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou
Article

Prostacyclin Receptor-Dependent Inhibition of Human Erythroleukemia Cell Differentiation is STAT3-Dependent

Prostaglandins Leukotrienes and Essential Fatty Acids, v. 86, (3), March 2012, p. 119-126
Lau, Alaster H.Y.; Lai, Henry K.H.; Yeung, Barry H.S.; Leung, Sze Lee; Tsang, Suk Ying; Wong, Yung Hou; Wise, Helen
Article

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

Journal of Biological Chemistry, v. 287, (34), August 2012, p. 28362-28377
Hoffmann, Frauke; Mueller, Wiebke; Schuetz, Dagmar; Penfold, Mark E.; Wong, Yung Hou; Schulz, Stefan; Stumm, Ralf
Article

Activated Gαq subunits interact with the tumor suppressor Fhit and increase its expression and phosphorylation

Stephenson Cancer Center Mini Conference on Tumor Microenvironment and Drug Discovery, 2-3 Dec 2012, Oklahoma, USA, Abstract T1
Wong, Yung Hou
Conference paper

Expression of Toll-like receptor 4 signaling components in adult rat dorsal root ganglion cells

Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 2012, p. 40
Tse, Kai Hei; Chow, Kevin Bing Shui; Ng, K. Y.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Conference paper

Novel interaction between signal transducing G proteins and the Fhit tumor suppressor

8th Asia Pacific Multidisciplinary Meeting for Cancer Research, May 11 2012, Hong Kong, Abstract T4
Wong, Yung Hou
Conference paper
2011 11

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties

Xenobiotica, v. 41, (1), January 2011, p. 35-45
Zhu, Jing; Hu, Yueqing; Ho, Maurice K.C.; Wong, Yung Hou
Article

Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms

Cellular Signalling, v. 23, (11), November 2011, p. 1727-1737
Wan, Guoqiang; Zhou, Lihan; Lim, Qing `En; Wong, Yung Hou; Too, Heng-Phon
Article

Expression of Gαz in C2C12 Cells Restrains Myogenic Differentiation

Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou
Article

Glial cells isolated from dorsal root ganglia express prostaglandin E2 (EP4) and prostacyclin (IP) receptors

European Journal of Pharmacology, v. 661, (1-3), July 2011, p. 42-48
Ng, Kai Yu; Wong, Yung Hou; Wise, Helen
Article

Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling

BMC Structural Biology, v. 11, April 2011, article number 17
Liu, A.M.F.; Lo, Kin H.; Guo, Emily X.; Ho, Maurice K.C.; Ye, Richard D.; Wong, Yung Hou
Article

RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling

Cancer Letters, v. 309, (2), October 2011, p. 199-208
Tso, Prudence H.; Yung, Lisa Y.; Wang, Yingchun; Wong, Yung Hou
Article

Regulation of Chemotaxis by Heterotrimeric G proteins

Chemotaxis: Types, Clinical Significance, and Mathematical Models / Edited by Timothy C. Williams. Hauppauge, N.Y.: Nova Science Publishers, c2011, p.109-134
Lee, Maggie M.K.; Wong, Yung Hou
Book chapter

Nm23-H1 inhibits oncogene-induced neoplastic transformation

Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U005
Tong, Yao; Wong, Yung Hou
Conference paper

Regulation of Fhit by Gq family proteins

Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U011
Zuo, H.; Chan, Anthony S.L.; Wong, Yung Hou
Conference paper

The expression of Toll-like receptor 4 in rat dorsal root ganglia

Annual Scientific Meeting of the Hong Kong Society of Immunology, Hong Kong, 7 May 2011
Chow, KB; Chu, TCH; Leung, WK; Wong, Yung Hou; Wise, Helen
Conference paper

Understanding the role of RGS20 in tumorigenesis

Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U004
Yang, L.; Wong, Yung Hou
Conference paper
2010 17

Activation of STAT3 by specific Gα subunits and multiple Gβγ dimers

International Journal of Biochemistry and Cell Biology, v. 42, (6), June 2010, p. 1052-1059
Yuen, J.W.F.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Yu, Frances W.Y.; Lo, Kin H.; Wong, Yung Hou
Article

Gα16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)

Cellular Signalling, v. 22, (10), October 2010, p. 1448-1458
Liu, A.M.F.; Lo, Kin H.; Lee, Mei Ki; Wang, Yingchun; Yeung, Wendy W.S.; Ho, Maurice K.C.; Su, Yan; Ye, Richard D.; Wong, Yung Hou
Article

Gα16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling

Cellular Signalling, v. 22, (9), September 2010, p. 1379-1387
Yeung, Wing Shan; Wong, Yung Hou
Article

In Search of Novel and Therapeutically Significant Melatoninergic Ligands

Frontiers in CNS Drug Discovery, v. 1, 2010, p. 600-610
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou
Article

In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator

Drug Metabolism and Pharmacokinetics, v. 25, (5), November 2010, p. 477-486
Zhu, Jing; Lee, Stephanie; Ho, Maurice K.C.; Hu, Yueqing; Pang, Haihong; Ip, Fanny C.F.; Chin, Allison C.; Harley, Calvin B.; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Article

Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity

NeuroSignals, v. 18, (1), September 2010, p. 32-42
Yung, H.S.; Lai, K.H.; Chow, Kevin B.S.; Ip, Nancy Yuk-Yu; Tsim, Karl Wah Keung; Wong, Yung Hou; Wu, Zhenguo; Wise, Helen
Article

RGS19 enhances cell proliferation through its C-terminal PDZ motif

Cellular Signalling, v. 22, (11), November 2010, p. 1700-1707
Tso, Ha; Wang, Yingchun; Wong, Sivia Y.S.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT2-selective melatonin ligands

Bioorganic and Medicinal Chemistry Letters, v. 20, (8), April 2010, p. 2582-2585
Hu, Yueqing; Ho, Kwok Chung Maurice; Chan, King Hang; New, David C.; Wong, Yung Hou
Article

The role of glial cells in influencing neurite extension by dorsal root ganglion cells

Neuron Glia Biology, v. 6, (1), February 2010, p. 19-29
Ng, Kai-Yu; Wong, Yung Hou; Wise, Helen
Article

Functional Impacts of Signal Integration: Regulation of Inflammation-related Transcription Factors by Heterotrimeric G Proteins

Molecular to Modular Tumor Therapy: Tumors are Reconstructible Communicatively Evolving Systems / Edited by Albrecht Reichle. Dordrecht: Springer Science+Business Media B.V., 2010, p.161-189
Yeung, Wing Shan; Ho, Maurice K.C.; Wong, Yung Hou
Book chapter

An investigation into the role of AGS3 in opiate tolerance and dependency

28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract PS13
Tse, Man Kit; Morris, Christina J.; Wong, Yung Hou
Conference paper

Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

Hong Kong Biochemistry Postgraduate Student Conference, 15 May 2010, Hong Kong, Abstract BCH10-A45
Hu, Sharry Y.; Ho, Maurice K.C.; Chan, King Hang; New, David C.; Wong, Yung Hou
Conference paper

Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

PepCon 2010, 20-22 March 2010, Beijing, China
Ho, Maurice K.C.; Hu, Sharry Y.; Chan, King Hang; Zhu, Jing; Wong, Yung Hou
Conference paper

Differential activation of G protein family members: GTPgammaS triggers subunit dissociation of Gi3 but not Gq.

28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, Yung Hou
Conference paper

Functional coupling of Melatonin receptors with G16 leads to independent phosphorylation of Tyr-705 and Ser-727 on STAT3

The 28th Hong Kong Society of Neuroscience (HKSN) Annual Meeting, 7-8 June 2010, Hong Kong, Abstract T6
Lau, Winnie W.I.; Chan, Anthony S.L.; Wong, Yung Hou
Conference paper

Melatonin MT1 receptor induces Fhit phosphorylation through the pertussis toxin-insensitive G16 protein

28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Zuo, H.; Chan, Siu Lung Anthony; Wong, Yung Hou
Conference paper

Structure-activity relationships of novel subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract Y6
Chan, King Hang013378; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou
Conference paper
2009 31

A Hematopoietic Perspective on the Promiscuity and Specificity of Gα16 Signaling

NeuroSignals, v. 17, (1), February 2009, p. 71-81
Su, Yan; Ho, Maurice K.C.; Wong, Yung Hou
Article

CCR1-mediated activation of nuclear factor-κB in THP-1 monocytic cells involves pertussis toxin-insensitive Gα14 and Gα16 signaling cascades

Journal of Leukocyte Biology, v. 86, (6), December 2009, p. 1319-1329
Lee, Mei Ki; Wong, Yung Hou
Article

Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation

NeuroSignals, v. 17, (2), May 2009, p. 111-120
Ng, Yu Pong; Wu, Zhenguo; Wise, Helen; Tsim, Karl Wah Keung; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Article

G Protein signaling controls the differentiation of multiple cell lineages

BioFactors, v. 35, (3), May 2009, p. 232-238
Wang, Kepeng; Wong, Yung Hou
Article

Gβ3 forms distinct dimers with specific Gγ subunits and preferentially activates the β3 isoform of phospholipase C

Cellular Signalling, v. 21, (5), May 2009, p. 737-744
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Multiple Gi Proteins Participate in Nerve Growth Factor-Induced Activation of c-Jun N-terminal Kinases in PC12 Cells

Neurochemical Research, v. 34, (6), June 2009, p. 1101-1112
Tso, Ha; Morris, Christina Jane; Yung, Ying; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Article

Multiplex fluorimetric assays for monitoring algal toxins

Journal of the Marine Biological Association of the United Kingdom, v. 89, (2), March 2009, p. 287-293
Mak, Carmen K.M.; Yeung, Patrick K.K.; Kwok, Chun Man; Wong, Yung Hou; Wong, Joseph T.Y.
Article

Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells

Cell Biology International, v. 33, (2), February 2009, p. 230-238
Chan, Grace P.W.; Wu, Eddy H.T.; Wong, Yung Hou
Article

Regulation of transcription factors by heterotrimeric G proteins

Current Molecular Pharmacology, v. 2, (1), 2009, p. 19-31
Ho, Maurice K.C.; Su, Yan; Yeung, Wing Shan; Wong, Yung Hou
Article

Reporter Gene Assays

Methods in Molecular Biology (Clifton, N.J.), v. 486, 2009, p. 109-123
Liu, A.M.F.; New, David C.; Lo, Kin H.; Wong, Yung Hou
Article

The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Gα16 and inhibits the canonical phospholipase Cβ pathway

Cellular Signalling, v. 21, (8), August 2009, p. 1317-1325
Yeung, Wing Shan; Wong, Yung Hou
Article

Effect of cicaprost on differentiation of human erythroleukemia (HEL) cells

12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P10, 12-15 June 2009
Lai, K.H.; Lau, H.Y.A.; Tsang, Shui Ying; Wong, Yung Hou; Wise, H.
Conference paper

Effects of Activator of G-protein Signaling 3 upon K-Opioid Receptor Signaling

The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Tse, Man Kit; Wong, Yung Hou; Morris, Christina J.
Conference paper

GAIP inhibits Ras signaling and tumor formation

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-47, 11-15 January 2009
Wang, Y.; Tso, Ha; Wong, Yung Hou
Conference paper

Galphaq subunits interact with the Fhit tumor suppressor

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-40, 11-15 January 2009
Chan, G.P.W.; Chan, W.W.I.; Wong, Yung Hou
Conference paper

Galphaz-regulated myogenic and osteogenic differentiation of C2C12 cells

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-45, 11-15 January 2009
Wang, K.; Yung, Ying; Ho, Maurice K.C.; Wong, Yung Hou
Conference paper

GPCR signaling: role in cell proliferation and differentiation

12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract PL2, 12-15 June 2009
Wong, Yung Hou
Conference paper

Identification of Novel Binding Partners of GAIP

The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Leung, Sing; Morris, Christina J.; Wong, Yung Hou
Conference paper

In vitro pharmacological characterizations of novel receptor subtype-spepcific melatoninergic ligands

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-39, 11-15 January 2009
Zhu, Jing; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou
Conference paper

Melatonin MT1 and MT2 knockout mice exhibit impaired circadian rhythm re-entrainment

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-48, 11-15 January 2009
Xu, Y.; Ho, Maurice K.C.; Wong, Yung Hou
Conference paper

Melatonin MT1 Receptor-mediated PKD Activation

Gordon Research Conferences on Mechanisms Of Cell Signalling - Towards Understanding Signalling Networks, 23-28 August, Oxford, UK
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou
Conference paper

Melatonin MT2 receptor activates STAT3 through the pertussis toxin-insensitive G16 protein

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-39, 11-15 January 2009
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou
Conference paper

Molecular determinants for G betagamma-induced activation of phospholipase C-beta isoforms

The 6th Asian Biophysics Association Symposium & 27th Hong Kong Society of Neuroscience Annual Meeting
Poon, See Wing; Chan, Anthony S.L.; Wong, Yung Hou
Conference paper

Molecular determinants for Gbetagamma-induced activation of phospholipase C isoforms

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-46, 11-15 January 2009
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou
Conference paper

Prostanoid-stimulated cAMP production in rat dorsal root ganglion cells: role of non-neuronal cells

12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P6, 12-15 June 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen
Conference paper

RhoA-specific guanine nucleotide exchange factor p63RhoGEF modulates Galpha16 signaling

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-52, 11-15 January 2009
Yeung, Wing Shan; Wong, Yung Hou
Conference paper

Role of non-neuronal cells on influencing neurite extension by rat dorsal root ganglion cell neurons

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-23, 11-15 January 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen
Conference paper

Role of PKC in melatonin receptor-mediated STAT3 activation

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract S16-7, 11-15 January 2009
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou
Conference paper

Structure-activity relationships of novel melatonin MT2 subtype-selective ligands with non-indoleamine scaffolds

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-44, 11-15 January 2009
Chan, S.K.H.; Ho, Maurice K.C.; Wong, Yung Hou
Conference paper

Targeting RGS proteins for the modulation of GPCR signaling

12th SCBA International Symposium, Taiwan, Abstract 7B-4, 14-18 June 2009
Wong, Yung Hou
Conference paper

TPR1 is required for Galphaq-mediated Ras signaling

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-38, 11-15 January 2009
Kwan, D.H.T.; Liu, A.M.F.; Wong, Yung Hou
Conference paper
2008 14

Activation of the human FPRL-1 receptor promotes Ca2+ mobilization in U87 astrocytoma cells

Neurochemical Research, v. 33, (1), January 2008, p. 125-133
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou
Article

Differential involvement of Gα16 in CC chemokine-induced stimulation of phospholipase Cβ, ERK, and chemotaxis

Cellular Signalling, v. 20, (6), June 2008, p. 1179-1189
Tian, Yaji; Lee, Maggie M.K.; Yung, Lisa Y.; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Wong, Yung Hou
Article

Mutations on the switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors

Journal of Molecular Signaling, v. 3, November 2008, article number 17
Yu, May Y.M.; Ho, Maurice K.C.; Liu, A.M.F.; Wong, Yung Hou
Article

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Current Medicinal Chemistry, v. 15, (25), October 2008, p. 2592-2613
Fu, Guangmiao; Pang, Haihong; Wong, Yung Hou
Article

Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via Gi/o proteins

Cellular Signalling, v. 20, (8), August 2008, p. 1538-1544
Yung, Ying; Tso, Ha; Wu, Eddy H.T.; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Article

Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Gαs and Gα16 hybrid signaling

Cellular Signalling, v. 20, (11), November 2008, p. 2095-2106
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou
Article

AGS3 modulation of ERK phosphorylation by the kappa-opioid receptor

9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS21, 25-26 March 2008
Morris, Christina Jane; Wong, Yung Hou
Conference paper

AGS3 Modulation of ERK Phosphorylation by the Kappa-Opioid Receptor

The 39th Annual International Narcotics Research Conference (INRC), Charleston, SC. USA. July 13-18, 2008
Morris, Christina J.; Tse, Man Kit; Wong, Yung Hou
Conference paper

Formation of specific G protein Betagamma-dimers and their corresponding activation of phospholipase C isoforms

9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS24, 25-26 March 2008
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou
Conference paper

Galpha14 signaling through TPR1: a structural and functional perspective

9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS22, 25-26 March 2008
Kwan, D.H.T.; Wong, Yung Hou
Conference paper

GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells


Ho, Kwok Chung Maurice; Mei, Hua; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Conference paper

Influence of glial cells on stress-induced neurite retraction in rat dorsal root ganglion cells

APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Ng, K.Y.; Wong, Yung Hou; Wise, Helen
Conference paper

Melatonin MT1 receptor-mediated STAT3 activation through Galpha16

9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS25, 25-26 March 2008
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou
Conference paper

Nerve growth factor-induced differentiation of rat pheochromocytoma (PC12) cells leads to changes in adenylyl cyclase activity

APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Lai, K.H.; Yung, H.S.; Wong, Yung Hou; Wise, Helen
Conference paper
2007 12

Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress

Apoptosis, v. 12, (1), January 2007, p. 167-179
Chan, Siu Lung Anthony; Ng, Linda W.C.; Poon, Lydia See Wing; Chan, Winnie W.Y.; Wong, Yung Hou
Article

Expression of G protein beta subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling

Neuroscience, v. 146, (2), May 2007, p. 594-603
Lok, Ka Chun; Fu, Amy Kit Yu; Ip, Fanny Chun Fun; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Article

Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1α in human U87 astrocytoma cells

Cellular Signalling, v. 19, (10), October 2007, p. 2106-2117
Kam, Angel Y.F.; Tse, Timothy T.M.; Kwan, Dawna H.T.; Wong, Yung Hou
Article

Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-κB kinase in human U87 astrocytoma cells

Journal of Neurochemistry, v. 103, (4), November 2007, p. 1553-1566
Kam, Angel Y.F.; Liu, Andrew M.F.; Wong, Yung Hou
Article

G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis

FEBS Journal, v. 274, (23), December 2007, p. 6025-6036
New, David C.; Wu, Kelvin; Kwok, Alice W.S.; Wong, Yung Hou
Article

In search of novel and therapeutically significant melatoninergic ligands

Recent Patents on CNS Drug Discovery, v. 2, (3), November 2007, p. 241-245
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou
Article

Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression

Journal of Molecular Signaling, v. 2, February 2007, article number 2
New, David C.; Wong, Yung Hou
Article

NRG induces membrane targeting of Gαz in muscle: implication in myogenesis

NeuroReport, v. 18, (14), September 2007, p. 1433-1436
Lok, Ka Chun; Fu, Kit Yu; Ip, Fanny C.F.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Article

Adenylyl cyclase activity during NGF-induced differentiation of rat pheochromocytoma (PC12) cells

Croucher Advanced Study Institute on Movement Disorders: Basic and Clinical Sciences, Hong Kong., 27 November - 1 December 2007
Yung, H.S.; Lai, K.H.; Wong, Yung Hou; Wise, Helen
Conference paper

Drug Development Candidate TAT2 Activates Telomerase in Primary Neuronal Cultures


An, Hui Jin; Ip, Fanny C.F.; Hu, Sharry Y; Ho, Maurice K C; Chin, A.C.; Harley, C.B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Conference paper

Identification of subtype-selective melatonin receptor ligands from traditional Chinese medicine

MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong, 5-6 March 2007. Abstract P042.
Ho, Maurice K.C.; New, David C.; Hu, Sharry Y.; Pang, Haihong; Wong, Yung Hou
Conference paper

Knowledge-Based Drug Discovery: Identification of Novel Leads From Traditional Chinese Medicine


Pang, Haihong; Hu, Sharry Y.; Ho, Maurice K C; Ip, Fanny C.F.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Conference paper
2006 28

Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells

Cellular Signalling, v. 18, (3), March 2006, p. 258-293
Wu, Eddy H.T.; Wong, Yung Hou
Article

Activation of STAT3 by Gαs Distinctively Requires Protein Kinase A, JNK, and Phosphatidylinositol 3-Kinase

Journal of Biological Chemistry, v. 281, (47), November 2006, p. 35812-35825
Liu, A.M.F.; Lo, Kin H.; Wong, Cecilia S.S.; Morris, Christina; Wise, Helen; Wong, Yung Hou
Article

CKBM stimulates MAPKs but inhibits LPS-induced IFN-γ in lymphocytes

Phytotherapy Research, v. 20, (9), September 2006, p. 725-731
Chan, Siu Lung Anthony; Yip, Eric C.H.; Yung, Ying; Pang, Haihong; Luk, Sharon C.W.; Pang, Shin F.; Wong, Yung Hou
Article

Constitutively active α subunits of Gq/11 and G2/13 families inhibit activation of the pro-survival Akt signaling cascade

FEBS Journal, v. 273, (11), June 2006, p. 2388-2398
Wu, Eddy H.T.; Tam, Becky H.L.; Wong, Yung Hou
Article

GABAB heterodimeric receptors promote Ca2+ influx via store-operated channels in rat cortical neurons and transfected chinese hamster ovary cells

Neuroscience, v. 137, (4), 2006, p. 1347-1358
New, David C.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Article

Involvement of calcium mobilization from caffeine-sensitive stores in mechanically induced cell cycle arrest in the dinoflagellate Crypthecodinium cohnii

Cell Calcium, v. 39, (3), March 2006, p. 259-274
Yeung, Patrick Ka Kit; Lam, Connie Mo Ching; Ma, Zhiyi; Wong, Yung Hou; Wong, Joseph T.Y.
Article

Opioid receptor-like (ORL1) receptor utilizes both G(0A) and G(0B) for signal transduction

Protein & Peptide Letters, v. 13, (5), May 2006, p. 437-441
Tso, Ha; Wong, Yung Hou
Article

Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK

Cellular Signalling, v. 18, (3), March 2006, p. 307-317
Lo, Kin H.; Wise, Helen; Wong, Yung Hou
Article

Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism

Cell Biology and Toxicology, v. 22, (4), July 2006, p. 293-302
Yip, E.C.H.; Chan, Siu Lung Anthony; Pang, Haihong; Tam, Y.K.; Wong, Yung Hou
Article

The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-kappa B in Jurkat T-cells and THP-1 monocytic cells

American Journal of Chinese Medicine, v. 34, (2), 2006, p. 263-278
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou
Article

Transcriptional activation of c-Fos by constitutively active Gα16QL through a STAT1-dependent pathway

Cellular Signalling, v. 18, (12), December 2006, p. 2143-2153
Lo, Kin H.; Wong, Yung Hou
Article

Tuberin: A Stimulus-Regulated Tumor Suppressor Protein Controlled by a Diverse Array of Receptor Tyrosine Kinases and G Protein-Coupled Receptors

NeuroSignals, v. 15, (5), July 2006, p. 217-227
Wu, Eddy H.T.; Wu, Kelvin K.H.; Wong, Yung Hou
Article

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity [Book review]

ChemMedChem, v. 1, (7), July 2006, p. 741-742
Wong, Yung Hou
Book review

A time-dependent loss of prostaglandin EP3 receptors in PC12 cells during neuroal differentiation

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Yung, H.S.; Wong, Yung Hou; Wise, Helen
Conference paper

Apoptosis of human neuroblastoma SK-N-MC cells induced by dopamine and norepinephrine

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, Siu Lung Anthony; Ng, L.W.C.; Poon, Lydia See Wing; Chan, W.W.Y.; Wong, Yung Hou
Conference paper

Axin Is Involved in Nerve Growth Factor-Induced Differentiation of PC12 Cells


Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Conference paper

Cell-based Fluorimetric assays for monitoring Gembierddiscus toxins

Proceedings of the Third International Conference on the Prevention and Management of Harmful Algal blooms in the South China Sea, p1-5. June, 2006. The Association on Harmful Algal Blooms in the South China Sea
Mak, Carmen K.M.; Yeung, Patrick K.K.; Wong, Yung Hou; Wong, Joseph T.Y.
Conference paper

Co-stimulation of Galphas alters Galpha16-mediated STAT3 activation.

Croucher Advanced Study Institute on Signaling in Cell Growth and Differentiation, Hong Kong, Abstract., 2006
Wong, Yung Hou
Conference paper

Ga sub(16) Binds to RhoA-Specific Guanine Nucleotide Exchange Factor p63RhoGEF and Competes with the Canonical PLC/PKC Pathway

46th Annual Meeting of the American Society for Cell Biology, San Diego Convention center, San Diego, California (USA), 9-13 Dec 2006
Yeung, W.W.S.; Wong, Yung Hou
Conference paper

Ga sub(s) Mediates b sub(2)-Adrenergic Receptor-Induced Stat3 Phosphorylation

4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Liu, A.M.F.; Lo, Kin H.; Wong, C.S.S.; Morris, Christina Jane; Wise, Helen; Wong, Yung Hou
Conference paper

Galpha14 interacts with tetratricopeptide repeat 1 for Ras signaling

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov ember 30 - December 2, 2006. Abstract.
Kwan, D.H.T.; Wong, Yung Hou
Conference paper

Galpha16 binds to RhoA-specific guanine nucleotide exchange factor p63RhoGEF and competes with the canonical PLC/PKC pathway

45th Annual Meeting of the American Society for Cell Biology, San Diego, USA, 13-17 December 2006. Abstract 67.
Yeung, Wing Shan; Wong, Yung Hou
Conference paper

Modulation of kappa-opioid signaling by RGS proteins

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Tso, Ha; Wong, Yung Hou
Conference paper

Opioid-induced pro-survival signals and the Akt/Tuberin pathway

Intl Narcotics Res Conf, Minnesota, USA, 9-14 July 2006, Abstract S II-5
Wong, Yung Hou
Conference paper

p63RhoGEF, a membrane-bound guanine nucleotide exchange factor, modulates signaling by heterotrimeric G proteins

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov 30 - Dec 2, 2006, Abstract
Yeung, Wing Shan; Wong, Yung Hou
Conference paper

Regulatory mechanism of mTOR and p70 S6 kinase by muscarinic M4 receptors in PC12 cells

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, G.P.W.; Wu, Eddy H.T.; Wong, Yung Hou
Conference paper

Role of Axin in Nerve Growth Factor-Induced Differentiation of PC12 Cells


Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Conference paper

The down-regulation of prostaglandin EP3 receptor subtype during neuronal differentiation

IUPHAR 2006, Beijing, China, Abstract
Yung, H.S.; Wong, Yung Hou; Wise, Helen
Conference paper
2005 33

Activation of nuclear factor κB by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves Gα14 and multiple signaling components: A mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src

Journal of Biological Chemistry, v. 280, (41), October 2005, p. 34617-34625
Liu, A.M.F.; Wong, Yung Hou
Article

Activation of δ-, κ-, and μ-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells

Biochemical and Biophysical Research Communications, v. 334, (3), September 2005, p. 838-844
Wu, Eddy H.T.; Wong, Yung Hou
Article

An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity

Phytomedicine, v. 12, (10), November 2005, p. 748-759
Yip, Eric Chun Hung; Liu, A.M.F; Wong, Joseph T.Y.; Wong, Yung Hou
Article

Carvacrol and eugenol differentially stimulate intracellular Ca2+ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells

Planta medica, v. 71, (7), July 2005, p. 634-639
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou
Article

Chimeric and Promiscuous G Proteins in Drug Discovery and the Deorphanization of GPCRs

Drug Design Reviews Online, v. 2, (1), February 2005, p. 66-79
New, David C.; Wong, Yung Hou
Article

Gq-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the Gs-Coupled Dopamine D1 Receptor in COS-7 Cells

Molecular Pharmacology, v. 68, (5), November 2005, p. 1354-1364
Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells

Biological and Pharmaceutical Bulletin, v. 28, (9), September 2005, p. 1645-1650
Chan, Siu Lung Anthony; Yip, Eric Chun Hung; Yung, Ying; Pang, Haihong; Luk, Sharon; Pang, Shiufun; Wong, Yung Hou
Article

Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells

Journal of Neurochemistry, v. 94, (5), August 2005, p. 1457-1470
Chan, Siu Lung Anthony; Yeung, Wendy W.S.; Wong, Yung Hou
Article

Involvement of Gi/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons

Molecular Pharmacology, v. 67, (4), April 2005, p. 1195-1205
Wu, Eddy H.T.; Wong, Yung Hou
Article

Mu-Opioid Receptor-Mediated Phosphorylation of IκB Kinase in Human Neuroblastoma SH-SY5Y Cells

NeuroSignals, v. 14, (3), July 2005, p. 136-142
Liu, A.M.F.; Wong, Yung Hou
Article

Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells

Cellular Signalling, v. 17, (7), July 2005, p. 881-890
Wu, Eddy H.T.; Wong, Yung Hou
Article

Molecular Basis of Opioid Actions: Regulation of Mitogen-activated Protein Kinases

Recent Developments in Pain Research, 2005 / Edited by Anna Capasso. Research Signpost Publishers, 2005, p. 41-58
Chan, Siu Lung Anthony; New, David C.; Wong, Yung Hou
Book chapter

Activated Galpha11, Galpha12, and Galpha13 inhibit activation of the pro-survival AKT signaling cascade

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-25.
Tam, H.L.; Wu, Eddy H.T.; Wong, Yung Hou
Conference paper

Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract O-12.
Wu, Eddy H.T.; Wong, Yung Hou
Conference paper

Activation of the human FPRL-1 receptor promotes Ca2+ mobilization and stimulates mitogen-activated protein kinases in U87 astrocytoma cells.

25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-9., 2005
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou
Conference paper

Differential regulation of signal transducers and activators of transcription by G protein subunits

24th Scientific Meeting of the Kong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-37.
Yuen, J.W.F.; Wong, Yung Hou
Conference paper

Expression profiling of Galphaz-regulated genes

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-23.
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou
Conference paper

Function of Galphaz in muscle differentiation

HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong., 10-12 March 2005
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou
Conference paper

G14-mediated stimulation of NFkappaB by the type 2 somatostatin receptor

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-29
Liu, A.M.L.; Wong, Yung Hou
Conference paper

Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation


Xiao, Fang; Ng, Yu Pong; Tsim, Karl Wah Keung; Wise, Helen; Wong, Yung Hou; Ip, Nancy Yuk-Yu; Wu, Zhenguo
Conference paper

Involvement of Gi/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC12 cells

HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Wu, Eddy H.T.; Wong, Yung Hou
Conference paper

New perspectives in G protein signaling: regulation of protein kinases and transcription factors.

25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Plenary Lecture I., 2005
Wong, Yung Hou
Conference paper

NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.


Leung, W.K.W.; Choi, Chi Yan; Ip, Nancy Yuk-Yu; Wu, Zhenguo; Wong, Yung Hou; Cheung, P.T.; Tsim, Karl Wah Keung
Conference paper

Overexpression of Galphaz Inhibits Muscle Differentiation


Mei, Hua; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Conference paper

Regulation of STAT3 phosphorylation by Galphas.

25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong. Abstract P3., 2005
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou
Conference paper

Role of Axin in Nerve Growth Factor-Stimulated Neurite Outgrowth


Ng, Yu Pong; Lin, Shengcai; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Conference paper

Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.


Kam, Yuet Fong; Yung, Ying; Wu, Eddy H.T.; Ng, Yu Pong; Wu, Zhenguo; Tsim, Karl Wah Keung; Wise, Helen; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Conference paper

Screening for NMDA Receptor Antagonists Using Traditional Chinese Medicine


Ip, Fanny C.F.; An, Hui Jin; Chan, Agnes Wing Sze; Tong, Pui Sze; Hu, Sharry Y.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Conference paper

Stimulation of mitogen-activated protein kinases by the human FPRL-1 receptor

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-27.
Kam, Angel Y.F.; Tse, T.T.M.; New, David C.; Wong, Yung Hou
Conference paper

Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells

24th Scientific Meeting of the Hong Kong Society of Neurosciences Hong Kong, 13-14 January 2005, Abstract P-33
Yeung, Wing Shan; Chan, Siu Lung Anthony; Wong, Yung Hou
Conference paper

Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells

HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Yeung, Wing Shan; Wong, Yung Hou
Conference paper

The effect of NGF-induced differentiation on the expression of prostanoid receptors in PC12 cells.

25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-19., 2005
Yung, H.S.; Wong, Yung Hou; Wise, Helen
Conference paper

Unraveling chemokine signaling for drug discovery.

Pacifichem 2005, Hawaii, USA., 15-20 December 2005
Wong, Yung Hou
Conference paper
2004 18

Characterization of CHO cells stably expressing a Gα16/z Chimera for high throughput screening of GPCRs

Assay and Drug Development Technologies, v. 2, (3), June 2004, p. 269-280
New, David C.; Wong, Yung Hou
Article

Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Gα14-coupled pathways

European Journal of Immunology, v. 34, (3), March 2004, p. 785-795
Tian, Yaji; New, David C.; Yung, Ying; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Lee, Mei Ki; Wong, Yung Hou
Article

Epidermal growth factor differentially augments Gi-mediated stimulation of c-Jun N-terminal kinase activity

British Journal of Pharmacology, v. 142, (4), June 2004, p. 635-646
Chan, Siu Lung Anthony; Wong, Yung Hou
Article

G16-mediated Activation of Nuclear Factor κB by the Adenosine A1 Receptor Involves c-Src, Protein Kinase C, and ERK Signaling

Journal of Biological Chemistry, v. 279, (51), December 2004, p. 53196-53204
Liu, A.M.F.; Wong, Yung Hou
Article

Gβγ signaling and Ca2+ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by Gq-coupled receptors

Cellular Signalling, v. 16, (7), July 2004, p. 823-836
Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Identification of a stretch of six divergent amino acids on the α5 helix of Gα16 as a major determinant of the promiscuity and efficiency of receptor coupling

Biochemical Journal, v. 380, (2), June 2004, p. 361-369
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou
Article

Phosphatidylinositol-3 kinase is distinctively required for μ-, but not κ-opioid receptor-induced activation of c-Jun N-terminal kinase

Journal of Neurochemistry, v. 89, (2), April 2004, p. 391-402
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2

Cellular Signalling, v. 16, (4), April 2004, p. 477-486
Chu, Kit-Man; Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen
Article

Regulation of STAT3 by μ-opioid receptors in human neuroblastoma SH-SY5Ycells

NeuroReport, v. 15, (9), June 2004, p. 1431-1435
Yuen, Jessie W.F.; So, Ivy Y.W.; Kam, Angel Y.F.; Wong, Yung Hou
Article

Replacement of the α5 helix of Gα16 with Gαs-specific sequences enhances promiscuity of Gα16 toward Gs-coupled receptors

Cellular Signalling, v. 16, (1), January 2004, p. 51-62
Hazari Anjali Ajaykumar; Lowes, Vicki L.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou
Article

Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα14 Involves Multiple Intermediates

Molecular Pharmacology, v. 65, (6), June 2004, p. 1487-1439
Lo, Kin H.; Wong, Yung Hou
Article

κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells

Journal of Pharmacology and Experimental Therapeutics, v. 310, (1), July 2004, p. 301-310
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Atypical regulation of calcium signals in astrocytoma 1321N1 cells expressing the purinergic P2Y12 receptor.

The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-15, 4-7 February
Ho, Maurice K.C.; Simon, J.; Barnard, E.A.; Wong, Yung Hou
Conference paper

Gi family members participate in nerve growth factor-mediated translational control in PC12 cells

Gordon Research Conference on Molecular & Cellular Neurobiology, Hong Kong, P65, 6-11 June
Wu, Eddy H.T.; Wong, Yung Hou
Conference paper

Opioid-mediated regulation of protein kinases and transcription factors

The 3rd Meeting of Asian Pacific Opioid Symposium on Molecular Basis of Opioid Tolerance and Dependence, Kyoto, Japan, 18 July 2004, Abstract
Wong, Yung Hou
Conference paper

Purinergic regulations of mitogen-activated protein kinases and calcium mobilization in rat brain capillary endothelial B10 cells

The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-12, 4-7 February
Wong, Yung Hou; Ho, Maurice K.C.; Leung, E.H.Y.; Simon, J.; Barnard, E.A.
Conference paper

Regulation of nuclear factor kappaB and STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells

Intl Narcotics Res Conf, Kyoto, Japan, 18-23 July 2004, Abstract P-52
Wong, Yung Hou; Liu, A.M.F.; Yuen, J.W.F.; Kam, A.Y.F.
Conference paper

Requirement of Gi/o proteins and phosphatidylinositol-3-kinase in nerve growth factor-induced tuberin phosphorylation and degradation

The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-4, 4-7 February
Wu, Eddy H.T.; Wong, Yung Hou
Conference paper
2003 17

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates

FEBS Letters, v. 536, (1-3), February 2003, p. 157-160
New, David C.; Wong, Yung Hou
Article

CC chemokine receptor-coupled signalling pathways

生物化学与生物物理学报=Acta Biochimica et Biophysica Sinica, v. 2003, (09), 2003, p. 779-788
New, David C.; Wong, Yung Hou
Article

Constitutively Active Gα16 Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism

Journal of Biological Chemistry, v. 278, (52), December 2003, p. 52154-52165
Lo, Kin H.; Cheung, Helen; Wong, Yung Hou
Article

G Protein-Linked Effector and Second Messenger Systems Involved in Melatonin Signal Transduction

NeuroSignals, v. 12, (2), March 2003, p. 59-70
New, David C.; Tsim, Siu T.; Wong, Yung Hou
Article

Gα16/z chimeras efficiently link a wide range of G protein-coupled receptors to calcium mobilization

Journal of Biomolecular Screening, v. 8, (1), February 2003, p. 39-49
Liu, A.M.F.; Ho, Maurice K.C.; Wong, Cecilia S.S.; Chan, Jasmine H.P.; Pau, Anson H.M.; Wong, Yung Hou
Article

Molecular basis of opioid dependence: Role of signal regulation by G-proteins

Clinical and Experimental Pharmacology and Physiology, v. 30, (5-6), May-June 2003, p. 307-316
Tso, Ha; Wong, Yung Hou
Article

Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor

Journal of Neurochemistry, v. 84, (3), February 2003, p. 503-513
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Regulation of STAT3 activity by G16-coupled receptors

Biochemical and Biophysical Research Communications, v. 303, (3), April 2003, p. 920-925
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou
Article

Reporter gene assays and their applications to bioassays of natural products

Phytotherapy Research, v. 17, (5), May 2003, p. 439-448
New, David C.; Miller-martini, David M.; Wong, Yung Hou
Article

The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with G16

Journal of Neurochemistry, v. 87, (3), November 2003, p. 697-708
Chan, Anthony S.L.; Law, Ping Y.; Loh, Horace H.; Ho, Peter N.N.; Wu, Wai-Man; Chan, Joy S.C.; Wong, Yung Hou
Article

The β6/α5 regions of Gαi2 and GαoA increase the promiscuity of Gα16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylation

European Journal of Pharmacology, v. 473, (2-3), July 2003, p. 105-115
Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou
Article

Activation of STAT3 by hematopoietic-specific G proteins

10th Congress of Federation of Asian & Oceanian Biochemists and Molecular Biologists, India, Abstract S27, 7-11 December
Wong, Yung Hou; Lo, Kin H.
Conference paper

Constitutively active Galpha16 stimulates STAT1 via a c-Src/JAK- and ERK-dependent mechanism

43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 1573, 13-17 December
Lo, Kin H.; Wong, Yung Hou
Conference paper

Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced Akt signaling cascade in PC12 cells

23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract OP3, 9-10 December
Wu, E.H.T.; Wong, Yung Hou
Conference paper

Pertussis toxin-sensitive Gi/o proteins participate in nerve growth factor-induced activation of survival Akt kinase and nuclear factor kappaB

43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 67, 13-17 December
Wu, E.H.T.; Wong, Yung Hou
Conference paper

STAT3 activation by the delta-opioid receptor via Galpha14 involves c-Src/JAK- and ERK-dependent pathways

23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PP9, 9-10 December
Lo, Kin H.; Wong, Yung Hou
Conference paper

The Roles of G-Proteins in the Formation of Neuromuscular Junction and Myogenesis


Lok, Ka Chun; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Conference paper
2002 19

Characterization and Channel Coupling of the P2Y12Nucleotide Receptor of Brain Capillary Endothelial Cells

Journal of Biological Chemistry, v. 277, (35), August 2002, p. 37390-31400
Simon, Joseph; Filippov, Alexander K.; Göransson, Sara A.; Wong, Yung Hou; Frelin, Christian; Michel, Anton D.; Brown, David A.; Barnard, Eric A.
Article

Co-Expressions of Different Opioid Receptor Types Differentially Modulate Their Signaling via G16

NeuroSignals, v. 11, (2), March-April 2002, p. 115-122
Ho, Maurice K.C.; New, David C.; Wong, Yung Hou
Article

Constitutive activation of the opioid receptor-like (ORL1) receptor by mutation of Asn133 to tryptophan in the third transmembrane region

Journal of Neurochemistry, v. 83, (6), December 2002, p. 1461-1470
Kam, Kenneth Wan Lung; New, David C.; Wong, Yung Hou
Article

Integration of Signals from Receptor Tyrosine Kinases and G Protein-Coupled Receptors

NeuroSignals, v. 11, (1), January-February 2002, p. 5-19
Lowes, Vicki L.; Ip, Nancy Yuk-Yu; Wong, Ying Hou
Article

Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins

Cellular Signalling, v. 14, (3), March 2002, p. 249-257
Chan, Siu Lung Anthony; Lai, Frank; Lo, Kin H.; Voyno-yasenetskaya, Tatyana A.; Stanbridge, Eric John; Wong, Yung Hou
Article

Molecular determinants for the differential coupling of Gα16 to the melatonin MT1, MT2 and Xenopus Mel1c receptors

Journal of Neurochemistry, v. 80, (5), March 2002, p. 436-745
Lai, Frank; Mody, Sejal M.; Yung, Ying; Kam, Jason Y.M.; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou
Article

Prostanoid Signal Integration and Cross Talk

NeuroSignals, v. 11, (1), January-February 2002, p. 20-28
Wise, Helen; Wong, Yung Hou; Jones, Robert Leslie
Article

Signal Diversification by the Neuronal-Specific Gz Protein.

Neuro-Signals, 11: 170-171
Wong, Yung Hou
Article

The ORL1 Receptor: Molecular Pharmacology and Signalling Mechanisms

NeuroSignals, v. 11, (4), July 2002, p. 197-212
New, David C.; Wong, Yung Hou
Article

G protein structure diversity

Structure and Function of GPCRs in the Nervous System / 63-86
Ho, Maurice K.C.; Wong, Yung Hou
Book chapter

Atypical G protein signaling: The path to kinases

Croucher Advanced Study Institute on Cell Signaling and Gene Transcription, Croucher Foundation, Hong Kong, S2
Wong, Yung Hou
Conference paper

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor

22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P10
New, David C.; Wong, Yung Hou
Conference paper

Expressions of regulators of G protein signaling RGSZ1 and GAIP augment neuronal differentiation of PC12 cells

22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P12
Ho, Maurice K.C.; Wu, Eddy H.T.; Wong, Yung Hou
Conference paper

Involvement of G Protein Signaling Pathway at the Neuromuscular Junctions


Lok, Ka C.; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Conference paper

mu-Opioid receptor-mediated activation of c-Jun N-terminal kinase requires phosphatidylinositol 3-kinase

22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P13
Kam, Yuet Fong; Wong, Yung Hou
Conference paper

Nerve Growth Factor-Dependent Activation of C-Jun N-Terminal Kinase in PC12 Cells Is Mediated via Pertussis Toxin-Sensitive G Proteins


Tso, Ha; Yung, Ying; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Conference paper

Regulation of STAT3 activity by ORL1 receptor through Galpha16

22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract O6
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou
Conference paper

Signal diversification by the neuronal-specific Gz protein

Croucher Advanced Study Institute on Molecular Neuroscience Hong Kong University of Science and Technology
Wong, Yung Hou
Conference paper

The application of Galpha16/Z chimeras in high-throughput drug screening

Third International Symposium for Chinese Medicinal Chemists, Hong Kong, December
New, David C.; Ho, Maurice K.C.; Dai, Wei M.; Wong, Yung Hou
Conference paper
2001 19

A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine

Phytotherapy Research, v. 15, (6), September 2001, p. 487-492
Miller-martini, David M; Chan, Robbie Y.K.; Ip, Nancy Yuk-Yu; Sheu, S.J.; Wong, Yung Hou
Article

Bacterial formyl peptide mediated chemotaxis and extracellular acidification in shrimp haemocytes

Developmental and Comparative Immunology, v. 25, (4), May 2001, p. 269-277
Yip, Eric Chun Hung; Wong, Yung Hou; Wong, Joseph T.Y.
Article

Chimeric Gαq subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors

Journal of Pineal Research, v. 30, (3), April 2001, p. 171-179
Lai, Frank P.L.; Mody, Sejal M.; Yung, Ying; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou
Article

Gz signaling: Emerging divergence from Gi signaling

Oncogene, v. 20, (13 REV. ISS. 1), March 2001, p. 1615-1625
Ho, Maurice K.C.; Wong, Yung Hou
Article

Gα14 links a variety of Gi- and Gs-coupled receptors to the stimulation of phospholipase C

British Journal of Pharmacology, v. 132, (7), April 2001, p. 1431-1440
Ho, Maurice K.C.; Yung, Ying; Chan, Joy S.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou
Article

Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than Gi1 and Gi3

Neuroscience Letters, v. 299, (1-2), February 2001, p. 25-28
Tso, Ha; Wong, Yung Hou
Article

Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics

British Journal of Pharmacology, v. 134, (7), December 2001, p. 1375-1384
Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen
Article

Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells

Neuroscience Letters, v. 316, (1), December 2001, p. 13-16
Tso, Ha; Wong, Yung Hou
Article

The Cyclic AMP-Mediated Expression of Acetylcholinesterase in Myotubes Shows Contrasting Activation and Repression between Avian and Mammalian Enzymes

Molecular and Cellular Neuroscience, v. 17, (4), April 2001, p. 732-745
Choi, Roy Chi Yan; Siow, Nina Lam; Zhu, Shangquan; Wan, David Chi Cheong; Wong, Yung Hou; Tsim, Karl Wah Keung
Article

Applications of chimeric and mutant Ga16 subunits in ligand screening for orphan G protein-coupled receptors.

7th Annual Conference of the Society for Biomolecular Screening, Baltimore, USA., Abstract 10012
Wong, Yung Hou; Ho, Maurice K.C.
Conference paper

Neuronal Gz protein differentially regulates mitogen-activated protein kinases and signal transducers and activators of transcription

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P38
Ho, Maurice K.C.; Lo, Kin H.; Chan, Siu Lung Anthony; Tso, Ha; Wong, Yung Hou
Conference paper

Rac and Cdc42-dependent regulation of c-Jun N-terminal kinase by the opioid receptors.

International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong.
Kam, Angel Y.F.; Wong, Yung Hou
Conference paper

Regulation of STAT3 activity by heterotrimeric G proteins of the Gq subfamily.

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P26
Wong, Yung Hou; Lo, Kin H.; Ho, Maurice K.C.
Conference paper

Replacement of the C-terminal residues of Ga16 with Gai2 or Gao1 residues enhances its promiscuity for receptor recognition.

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P25
Wong, Cecilia S.S.; Pau, Anson H.M.; Wong, Yung Hou
Conference paper

Selected mutations in the a5 helix of Ga16 increase its promiscuity for receptors

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 37
Chan, Jasmine H.P.; Ho, Maurice K.C.; Wong, Yung Hou
Conference paper

Selected mutations of the a5 helix of Ga16 improves the coupling of Gi-linked receptor

International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou
Conference paper

Signaling from opioid receptors to c-Jun N-terminal kinase requires the small GTP-binding proteins Rac and Cdc42.

41st Annual Meeting of the American Society for Cell Biology, Washington, USA., Abstract 1233
Kam, Angel Y.F.; Wong, Yung Hou
Conference paper

Suppression of prostacyclin receptor-mediated phospholipase C stimulation by Ga14.

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P39
Lee, Mei Ki; Joshi, Sushma A.; Wise, Helen; Wong, Yung Hou
Conference paper

The regulation of c-Jun N-terminal kinase by opioid receptors involves Rac and Cdc42

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 24
Kam, Angel Y.F.; Wong, Yung Hou
Conference paper
2000 13

Activation of B-Raf and Regulation of the Mitogen-activated Protein Kinase Pathway by the Go α chain

Molecular Biology of the Cell, v. 11, (4), April 2000, p. 1129-1142
Antonelli, Valeria; Bernasconi, Francesca; Wong, Yung Hou; Vallar, Lucia
Article

Cloning of a novel G-protein-coupled receptor from the sea anemone nervous system

Biochemical and Biophysical Research Communications, v. 271, (3), May 2000, p. 761-769
New, David C.; Wong, Yung Hou; Wong, Joseph T.Y.
Article

Deciphering the role of Gi2 in opioid-induced adenylyl cyclase supersensitization

NeuroReport, v. 11, (14), September 2000, p. 3213-3217
Tso, Ha; Wong, Yung Hou
Article

Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by Gz and G12 proteins

Cellular Signalling, v. 12, (7), July 2000, p. 481-489
Belcheva, Mariana M.; Wong, Yung Hou; Coscia, Carmine J.
Article

Gz Can Mediate the Acute Actions of μ- and κ-Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization

Journal of Pharmacology and Experimental Therapeutics, v. 295, (1), October 2000, p. 168-176
Tso, Ha; Wong, Yung Hou
Article

Immunoglobulin G1 Fc Fragment-Tagged Human Opioid Receptor-Like Receptor Retains the Ability to Inhibit cAMP Accumulation

Biological Signals and Receptors, v. 9, (5), September-October 2000, p. 240-247
Yung, Ying; Tsim, Karl Wah Keung; Pei, Gang; Wong, Yung Hou
Article

Incorporation of Gαz-specific sequence at the carboxyl terminus increases the promiscuity of Gα16 toward Gi-coupled receptors

Molecular Pharmacology, v. 57, (1), January 2000, p. 13-23
Mody, Sejal M.; Ho, Maurice K.C.; Joshi, Sushma A.; Wong, Yung Hou
Article

Molecular mechanisms and regulation of opioid receptor signaling

Annual Review of Pharmacology and Toxicology, v. 40, April 2000, p. 389-430
Law, Pingyee; Wong, Yung Hou; Loh, Horace
Article

Preactivation Permits Subsequent Stimulation of Phospholipase C by G,sub>i-Coupled Receptors

Molecular Pharmacology, v. 57, (4), April 2000, p. 700-708
Chan, Joy S.C.; Lee, Jonathan W.M.; Ho, Maurice K.C.; Wong, Yung Hou
Article

Regulation of Adenylyl Cyclase, ERK1/2, and CREB by Gz Following Acute and Chronic Activation of the δ-Opioid Receptor

Journal of Neurochemistry, v. 74, (4), April 2000, p. 1685-1693
Tso, Ha; Yung, Ying; Wong, Yung Hou
Article

Regulation of C-jun N-terminal kinase by the ORL1 receptor through multiple G proteins

Journal of Pharmacology and Experimental Therapeutics, v. 295, (3), December 2000, p. 11094-1100
Chan, Siu Lung Anthony; Wong, Yung Hou
Article

The Amino Terminus of Gαz is Required for Receptor Recognition, Whereas its α4/β6 Loop Is Essential for Inhibition of Adenylyl Cyclase

Molecular Pharmacology, v. 58, (5), November 2000, p. 993-1000
Ho, Maurice K.C.; Wong, Yung Hou
Article

The Effect of Protein Kinase C Activation on Gz-Mediated Regulation of Type 2 and 6 Adenylyl Cyclases

Biological Signals and Receptors, v. 9, (1), January-February 2000, p. 21-28
Ho, Maurice K.C.; Chan, Joy S.C.; Yung, Ying; Wong, Yung Hou
Article
1999 7

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex

NeuroReport, v. 10, (9), June 1999, p. 1993-1996
Ho, Maurice Kwok Chung; Wong, Yung Hou
Article

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex

NeuroReport, v. 10, (7), May 1999, p. 1561-1564
Ho, Maurice K C; Wong, Yung Hou
Article

Chronic activation of ORL1 receptor induces supersensitization of adenylyl cyclase

NeuroReport, v. 10, (14), September 1999, p. 2901-2905
Chan, Robbie; Wong, Yung Hou
Article

Disruption of receptor-mediated activation of G protein by mutating a conserved arginine residue in the switch II region of the α subunit

Journal of Neurochemistry, v. 73, (5), November 1999, p. 2101-2109
Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou
Article

GL1 (Gα14) couples the opioid receptor-like1 receptor to stimulation of phospholipase C

Journal of Pharmacology and Experimental Therapeutics, v. 288, (1), January 1999, p. 232-238
Yung, Ying; Joshi, Sushma A.; Chan, Robbie Y.K.; Chan, Joy S.C.; Pei, Gang; Wong, Yung Hou
Article

Mutational analysis of the structure and function of opioid receptors

Biopolymers - Peptide Science Section, v. 51, (6), 1999, p. 440-455
Law, Pingyee; Wong, Yung Hou; Loh, Horace
Article

Stimulation of phospholipase C by the cloned μ, δ and κ opioid receptors via chimeric Gαq mutants

European Journal of Neuroscience, v. 11, (2), January 1999, p. 383-388
Joshi, Sushma; Lee, Jonathan W.M.; Wong, Yung Hou
Article
1998 8

Chimeric Gαq mutants harboring the last five carboxy-terminal residues of Gαi2 or Gαo are resistant to pertussis toxin-catalyzed ADP-ribosylation

FEBS Letters, v. 441, (1), December 1998, p. 67-70
Joshi, Sushma A.; Fan, Kenneth P.K.; Ho, Vannessa W.S.; Wong, Yung Hou
Article

Differential coupling of μ-, δ-, and κ-opioid receptors to Gα16- mediated stimulation of phospholipase C

Journal of Neurochemistry, v. 70, (5), May 1998, p. 2203-2211
Lee, Jonathan W.M.; Joshi, Sushma A.; Chan, Joy S.C.; Wong, Yung Hou
Article

Evidence for heterotrimeric G proteins in sea anemones

Molecular Marine Biology and Biotechnology, v. 7, (1), March 1998, p. 31-38
New, David C.; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y.
Article

Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis

Journal of Pineal Research, v. 25, (4), December 1998, p. 219-228
Li, Lili; Xu, Jianning; Wong, Yung Hou; Wong, Joseph T.Y.; Pang, Shiufun; Shiu, Stephen Yuen Wing
Article

Pertussis Toxin-Insensitive Signaling of the ORL1 Receptor: Coupling to Gz and G16 Proteins

Journal of Neurochemistry, v. 71, (5), November 1998, p. 2203-2210
Chan, Joy S.C.; Yung, Ying; Lee, Jonathan W.M.; Wu, Yalan; Pei, Gang; Wong, Yung Hou
Article

Regulation of calcium influx and phospholipase C activity by indoleamines in dinoflagellate Crypthecodinium cohnii

Journal of Pineal Research, v. 24, (3), April 1998, p. 152-161
Tsim, Siu-Tai; Wong, Joseph T.Y.; Wong, Yung Hou
Article

Structure and Function of the Pertussis-Toxin-Insensitive Gz Protein

Biological Signals and Receptors, v. 7, (2), March-April 1998, p. 80-89
Ho, Maurice K.C.; Wong, Yung Hou
Article

The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP

Journal of Neurochemistry, v. 71, (1), July 1998, p. 152-160
Choi, Roy Chi Yan; Yung, Lisa Ying; Dong, Tina Ting Xia; Wan, David C.C.; Wong, Yung Hou; Tsim, Karl Wah Keung
Article
1997 5

Calcium ion dependency and the role of inositol phosphates in melatonin-induced encystment of dinoflagellates

Journal of Cell Science, v. 110, (12), June 1997, p. 1387-1393
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou
Article

Functional Role of Amino-Terminal Serine16 and Serine27 of Gαz in Receptor and Effector Coupling

Journal of Neurochemistry, v. 68, (6), June 1997, p. 2514-2522
Ho, Maurice K.C.; Wong, Yung Hou
Article

Melatonin and 5-methoxytryptamine induced muscular contraction in sea anemones

Journal of Experimental Zoology, v. 279, (3), October 1997, p. 201-207
Tsang, Wai Hung; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y.
Article

Receptor-induced βγ release from fatty acylation-deficient mutants of Gαz

NeuroReport, v. 8, (4), March 1997, p. 937-940
Beck, Helga I.; Chan, Joy S.C.; Wong, Yung Hou
Article

Role of Amino- and Carboxyl-Terminal Regions of Gαz in the Recognition of Gi-Coupled Receptors

Molecular Pharmacology, v. 52, (1), July 1997, p. 38-45
Tsu Rachel Caroline; Ho, Maurice K.C.; Yung, Ying; Joshi, Sushma A.; Wong, Yung Hou
Article
1996 6

CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin

Journal of Pineal Research, v. 21, (2), September 1996, p. 101-107
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou
Article

Effects of Dibutyryl cAMP and Bacterial Toxins on Indoleamine-Induced Encystment of Dinoflagellates

Biological Signals, v. 5, (1), January-February 1996, p. 22-29
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou
Article

Gi-mediated stimulation of type II adenylyl cyclase is augmented by Gq-coupled receptor activation and phorbol ester treatment

Journal of Neuroscience, v. 16, (4), February 1996, p. 1317-1323
Tsu, Rachel Caroline; Wong, Yung Hou
Article

Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: Role of G protein and adenylyl cyclase activation

Molecular Pharmacology, v. 50, (6), December 1996, p. 1651-1657
Chiu, Tillie T.; Yung, Ying; Wong, Yung Hou
Article

Possible involvement of G proteins in indoleamine-induced encystment in dinoflagellates

Molecular Marine Biology and Biotechnology, v. 5, (2), June 1996, p. 162-167
Tsim, Siu Tai; Yung, Ying; Wong, Joseph T.Y.; Wong, Yung Hou
Article

The G Protein Linkage of Melatonin Receptors

Frontiers of Hormone Research, v. 21, 1996, p. 147-153
Wong, Yung Hou
Article
1995 7

Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G Proteins

Journal of Neurochemistry, v. 65, (6), December 1995, p. 2682-2689
Chan, Joy S.C.; Chiu, Tillie T.; Wong, Yung Hou
Article

Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive Gz protein

Biochemical Journal, v. 309, (1), July 1995, p. 331-339
Tsu, Rachel Caroline; Lai, H.W.L.; Allen, Rodger A.; Wong, Yung Hou
Article

GZ coupling to the rat κ-opioid receptor

FEBS Letters, v. 360, (1), February 1995, p. 97-99
Lai, Helen W.L.; Minami, Masabumi; Satoh, Masamichi; Wong, Yung Hou
Article

Mutant α subunit of G(z) transforms Swiss 3T3 cells

Oncogene, v. 10, (10), May 1995, p. 1927-1933
Wong, Yung Hou; Chan, Joy S.C.; Yung, Ying; Bourne, Henry R.
Article

Regulation of multiple effectors by the cloned δ-opioid receptor: Stimulation of phospholipase C and type II adenylyl cyclase

Journal of Neurochemistry, v. 64, (6), June 1995, p. 2700-2707
Tsu, Rachel Caroline; Chan, Joy S.C.; Wong, Yung Hou
Article

Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins

FEBS Letters, v. 372, (1), September 1995, p. 99-102
Yung, Ying; Tsim, Siu Tai; Wong, Yung Hou
Article

Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors

Molecular Pharmacology, v. 47, (4), April 1995, p. 835-841
Tsu, Rachel Caroline; Allen, Rodger A.; Wong, Yung Hou
Article
1994 2

Gi Assays in Transfected Cells

Methods in Enzymology, v. 238, (C), January 1994, p. 81-94
Wong, Yung Hou
Article

Indolemine-induced encystment in dinoflagellates

J. Mar. Biol. Ass. U.K, v. 74, 1994, p. 467-469
Wong, J.T.Y.; Wong, Yung Hou
Article
1992 4

Detection of Coincident Signals by G Proteins and Adenylyl Cyclase

Cold Spring Harbor Symposia on Quantitative Biology, v. 57, 1992, p. 145-148
Bourne, H.R.; Lustig, K.; Wong, Yung Hou; Conklin, B.R.
Article

Gz-mediated hormonal inhibition of cyclic AMP accumulation

Science, v. 255, (5042), January 1992, p. 339-342
Wong, Yung Hou; Conklin, B.R.; Bourne, H.R.
Article

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C

Journal of Biological Chemistry, v. 267, (1), January 1992, p. 31-34
Conklin, B.R.; Chabre, O.; Wong, Yung Hou; Federman, A.; Bourne, H.R.
Article

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase

Journal of Biological Chemisty, v. 267, (29), October 1992, p. 20831-20834
Hung, D.T.; Wong, Yung Hou; Vu, T.K.; Coughlin, S.R.
Article
1991 3

A mutant α subunit of Gi2 induces neoplastic transformation of rat-1 cells

Proceedings of the National Academy of Sciences of the United States of America, v. 88, (16), August 1991, p. 7031-7035
Pace, A.M.; Wong, Yung Hou; Barnard, E.A.
Article

G protein oncogenes

In: Origins of Human Cancer: A Comprehensive Review, 1991, p. 327-333
Bourne, H.R.; Goretzki, P.; Landis, C.; Lyons, J.; McCormick, F.; Pace, A.; Wong, Yung Hou
Article

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

Nature, v. 351, (6321), May 1991, p. 63-65
Wong, Yung Hou; Federman, Alex; Pace, Ann M.; Zachary, Ian; Evans, Tony; Pouysségur, Jacques; Bourne, Henry R.
Article
1990 1

Agonist-selective protection of the opioid receptor-coupled G protein from inactivation by 5'-p-fluorosulphonylbenzoyl guanosine

Journal of Neurochemistry, v. 54, (1), January 1990, p. 39-45
Wong, Yung Hou; Demoliou-mason, C.D.; Hanley, M.R.; Barnard, E.A.
Article
1989 3

Opioid receptor-G protein interactions: pertussis toxin, Li+ effects and reconstitution studies

Li+ effects and reconstitution studies. Adv. Biosci, v. 75, 1989, p. 153-156
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.
Article

Opioid Receptors in Magnesium-Digitonin-Solubilized Rat Brain Membranes Are Tightly Coupled to a Pertussis Toxin-Sensitive Guanine Nucleotide-Binding Protein

Journal of Neurochemistry, v. 52, (4), April 1989, p. 0999-1009
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A.
Article

Uncoupling of the opioid receptor-G protein complexes by 5'-p-fluorosulphonylbenzoyl guanosine

Adv. Biosci., v. 75, 1989, p. 133-136
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.
Article
1988 2

A complex of opioid receptor with G protein, characterized in digitonin solution

In: Regulatory Roles of Opioid Peptides, Edited by Illes P and Farsang C. 1988, p. 131-144
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.
Article

ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes

Journal of Neurochemistry, v. 51, (1), July 1988, p. 114-121
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A.
Article
1987 1

Bradykinin stimulation of inositol phosphate and calcium responses is insensitive to pertussis toxin in NG115-401L neuronal cells

Biochemical and Biophysical Research Communications, v. 148, (1), October 1987, p. 412-416
Jackson, Trevor R.; Patterson, Sean I.; Wong, Yung Hou; Hanley, Michael R.
Article
1986 1

Effects of hypoxaemia and hyperoxaemia on some cardiovascular responses of rats to adrenaline

Archives of Physiology and Biochemistry, v. 94, (5), 1986, p. 323-329
Dai, S.; Wong, Yung Hou; Ogle, C.W.
Article
1985 1

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine

Pharmacology, v. 30, (6), 1985, p. 314-319
Dai, S.; Wong, Yung Hou
Article
Conference paper 1

Reconstructing Gαi1 into an effector-deficient mutant for the detection of receptor-activated Gβγ signals


Chan, Ho Yung; Wong, Yung Hou
Article 3

CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1

Scientific Reports, v. 11, (1), January 2021, article number 491
Wong, Ka Ming; Song, Jiaxing; Wong, Yung Hou

Modeling The Heterodimer Interfaces Of Melatonin Receptors

Frontiers in Cellular Neuroscience, v.15, 7 October 2021, article number 725296, p. 356-356
Tse, Lap Hang; Wong, Yung Hou

Re-examining the ‘Dissociation Model’ of G protein activation from the perspective of Gβγ signaling

FEBS Journal, v. 288, (8), April 2021, p. 2490-2501
Chung, Yin Kwan; Wong, Yung Hou
Conference paper 3

Allosteric modulations in signal transduction of the melatonin receptor heterodimer MT1/MT2


Tse, Lap Hang; Wong, Yung Hou

Nm23-H1 alters exosome content to abrogate pro-metastatic effect of breast cancer cell derived exosomes


Saini, Vasu; Wong, Yung Hou

Transcriptional targets of Nm23-H1 alter its metastasis suppressor function


Song, Jiaxing; Xie, Jia; Wong, Yung Hou
Article 4

Age Associated Decrease of MT-1 Melatonin Receptor in Human Dermal Skin Fibroblasts Impairs Protection Against UV-Induced DNA Damage

International Journal of Molecular Sciences, v. 21, (1), January 2020, article number 326
Dong, Kelly; Goyarts, Earl; Rella, Antonella; Pelle, Edward; Wong, Yung Hou; Pernodet, Nadine

AGS3 and Gαi3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells

Molecules (Basel, Switzerland), v. 25, (21), November 2020, article number 5169
Yip, Leung Kwan; Lee, Maggie M. K.; Leung, Crystal C. Y.; Tse, Man Kit; Cheung, Suet Ting; Wong, Yung Hou

Molecular basis defining the selectivity of substituted isoquinolinones for the melatonin MT2 receptor

Biochemical Pharmacology, v. 177, July 2020, article number 114020
Chan, King Hang; Tse, Lap Hang; Huang, Xuhui; Wong, Yung Hou

Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function

Molecular and Cellular Biochemistry, v. 474, (1-2), November 2020, p. 95-112
Li, Yuanjun; Liu, Wen; Saini, Vasu; Wong, Yung Hou
Conference paper 1

Anti-migratory effect of Nm23-H1 via exosomes


Saini, Vasu; Wong, Yung Hou; Sun, Siu Nam
Article 2

GPCRs in Autocrine and Paracrine Regulations

Frontiers in Endocrinology, v. 10, (JULY), July 2019, article number 428
Tse, Lap Hang; Wong, Yung Hou

Small molecules as drugs to upregulate metastasis suppressors in cancer cells

Current Medicinal Chemistry, v. 26, (32), November 2019, p. 5876-5899
Wong, Ka Ming; Song, Jiaxing; Saini, Vasu; Wong, Yung Hou
Conference paper 3

Generation of an effector-deficient Gαi1


Chung, Yin Kwan; Wong, Yung Hou

The role of leukemia inhibitory factor (LIF) in the intercellular communication between neurons and astrocytes. Abstract P48.


Gu, Yishan; Wong, Yung Hou

Unraveling the mechanism of RGS-induced upregulation of Nm23-H1. Abstract P68


Song, Jiaxing; Wong, Yung Hou
Conference paper 3

MT1 and MT2 melatonin receptors: heteromerization and functional significance


Tse, Lap Hang; Wong, Yung Hou

Non-dissociable Gβ-Gα fusion proteins reveal different mechanisms of G protein activation


Liu, Wen; Wong, Ka Ming; Chan, Siu Lung Anthony; Wong, Yung Hou

Regulation of metastasis suppressor genes mediated by breast cancer derived exosomes


Saini, Vasu; Wong, Yung Hou
Article 2

RGS19 Upregulates Nm23-H1/2 Metastasis Suppressors by Transcriptional Activation via the cAMP/PKA/CREB Pathway

Oncotarget, v. 8, (41), July 2017, p. 69945-69960
Li, Yuanjun; Song, Jiaxing; Tong, Yao; Chung, Sookjakim; Wong, Yung Hou

Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function

Molecules, v. 22, (7), July 2017, article number 1239
Leung, Ching Yiu Crystal; Wong, Yung Hou
Conference paper 6

Activation of PKA-dependent transcription factors by RGS19 upregulates metastasis suppressor Nm23-H1/2.


Song, Jiaxing; Wong, Yung Hou

Back to the basics: the G protein cycle


Wong, Yung Hou; Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming

Differential G protein subunit dissociation mechanisms suggest possible family-wise selective Gβγ signaling


Liu, Wen; Li, Jiayue; Zhou, Longyin; Wong, Yung Hou

Functional characterization of heteromerization effects of melatonin receptors


Tse, Lap Hang; Ng, Siu Wang; Chan, King Hang; Wong, Yung Hou

Gq signaling pathway of melatonin receptor in islets of Langerhans


Gu, Yishan; Chan, Sze Man; Wong, Yung Hou

Transcriptional and post-transcriptional regulation of NME1 in cancer metastasis.


Wong, Yung Hou; Wong, Ka Ming
Article 5

Anxiety and Depression with Neurogenesis Defects in Exchange Protein Directly Activated by cAMP 2-Deficient Mice are Ameliorated by a Selective Serotonin Reuptake Inhibitor, Prozac

Translational Psychiatry, v. 6, (9), September 2016, article number e881
Zhou, L.; Ma, Sukling; Yeung, Patrick Ka Kit; Wong, Yung Hou; Tsim, Karl Wah Keung; So, K. F.; Lam, L.C.W.; Chung, S.K.

Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by Gi- and Gq-Regulated Pathways

Journal of Molecular Biology, v. 428, (19), September 2016, p. 3869-3884
Chan, Anthony Siu Lung; Lau, Wai In; Szeto, Aydan C.H.; Wang, Jiuling; Wong, Yunghou

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai

Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species

Pharmaceutica Analytica Acta, v. 7, (4), April 2016, article number 1000474
Bi, Dan; Zhang, L.M.L.; Tang, Wai Lun; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Wong, Yung Hou; Lin, Huangquan; Tsim, Karl Wah Keung

Regulator of G Protein Signaling 20 Enhances Cancer Cell Aggregation, Migration, Invasion and Adhesion

Cellular Signalling, v. 28, (11), November 2016, p. 1663-1672
Yang, Lei; Lee, Mei Ki; Leung, Man Hon Manton; Wong, Yung Hou
Conference paper 4

Cdk5 Activity is Required for EphB-mediated Synaptogenesis


Chen, Yu; Wong, Yung Hou; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu

Flavonoids Induce the Expression of Acetylcholinesterase in Cultured Osteoblasts

Chemico-Biological Interactions, v. 259, (B), 25 November 2016, p. 295-300
Xu, Miranda Li; Bi, Wenchuan; Kong, Yeung Yeung Ava; Dong, Ting Xia; Wong, Yung Hou; Tsim, Karl Wah Keung

Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes


Wu, Y.; Chan, K.H.; Wong, Yung Hou

The role of RGS20 in cell cycle regulation and angiogenesis


Leung, M.; Alim, A.S.; Xu, R.; Wong, Yung Hou
Article 6

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gαi3

Molecular and Cellular Biochemistry, v. 401, (1-2), March 2015, p. 27-38
Tse, Man Kit; Morris, Christina Jane; Zhang, Mingjie; Wong, Yung Hou

An intact helical domain is required for Gα14 to stimulate phospholipase Cβ

BMC Structural Biology, v. 15, (1), September 2015, article number 18
Kwan, Dawna HT; Wong, Ka Ming; Chan, Anthony Siu Lung; Yung, Lisa Ying; Wong, Yung Hou

Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ

BMC Cancer, v. 15, (1), October 2015, article number 775
Zuo, Hao; Wong, Yung Hou

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai

Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis

Cancer Letters, v. 361, (2), June 2015, p. 207-217
Tong, Yao; Yung, Lisa Ying; Wong, Yung Hou

Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives

Naunyn-Schmiedeberg's Archives of Pharmacology, v. 388, (2), February 2015, p. 243-256
Li, Yuanjun; Tong, Yao; Wong, Yung Hou
Book chapter 1

RAS Genes

Encyclopedia of Cancer: a Springer Live Reference /Edited by Manfred Schwab. Berlin, Heidelberg : Springer, 2015, p. 1-6
Wong, Yung Hou; Pellicer, Angel; Liu, Wen
Conference paper 8

Activation Of Phospholipase Cβ By NonDissociable Gq Proteins


Wong, Yung Hou; Liu, W.; Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, K.M.

Functional characterization of type 2 diabetes associated MTNRIB variants


Wu, Y.; Chan, K.H.; Wong, Yung Hou

Inhibition of oncogenic Ras-induced tumorigenesis by Nm23 metastasis suppressors


Wong, Y.H.; Li, Y.

Involvement of G proteins in asymmetric cell division during neurogenesis


Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou

Molecular determinants of selective ligand binding at the human melatonin receptor


Chan, King Hang; Wong, Yung Hou

Non-dissociable Gβ-Gα Fusion Proteins Reveal Different Mechanisms Of G Protein Activation


Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming; Wong, Yung Hou

Post-transcriptional regulation of the regulator of G protein signaling 19 (RGS19) and metastasis suppressor Nm23 in cancer by microRNAs


Wong, Ka Ming; Wong, Yung Hou

Role of surface residues on defining the functional specificity of Nm23 metastasis suppressors


Li, Yuanjun; Wong, Yung Hou
Article 5

Angiotensin-[1-12] interacts with angiotensin type I receptors

Neuropharmacology, v. 81, June 2014, p. 267-273
Chan, King Hang; Chen, Yi Hung; Zhang, Ying; Wong, Yung Hou; Dun, Nae J.

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

NeuroSignals, v. 22, (1), May 2014, p. 52-63
Ip, Fanny Chui Fun; Ng, Yu Pong; An, Hui Jin; Dai, Ying; Pang, Hai Hong; Hu, Yue Qing; Chin, Allison C.; Harley, Calvin B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu

Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways

Neuroscience, v. 267, May 2014, p. 241-251
Tse, Kai Hei; Chow, K.B.S.; Leung, W.K.; Wong, Yung Hou; Wise, H.

Primary Sensory Neurons Regulate Toll-like receptor-4-dependent Activity of Glial Cells in Dorsal Root Ganglia

Neuroscience, v. 279, October 2014, p. 10-22
Tse, Kai-Hei; Chow, K.B.S.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen

Synthesis and Functional Characterization of Substituted Isoquinolinones as MT2-Selective Melatoninergic Ligands

PLoS ONE, v. 9, (12), December 2014, article number 0113638
Hu, Yueqing; Chan, King Hang; He, Xixin; Ho, Maurice Kwok Chung; Wong, Yung Hou
Conference paper 6

Activation of Gq without Subunits Dissociation


Liu, Wen; Wong, Yung Hou

Activation of PLCβ by a Non-dissociable Gq Protein


Liu, W.; Chan, Siu Lung Anthony; Wong, K.M.; Wong, Yung Hou

ENStem - A Cells as a Model for Studying Neurogenesis


Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou

Multi-faceted Metastasis Suppressor Nm23 is Up-regulated by RGS19 via Activating Transcription Factors


Li, Y.; Wong, Yung Hou

RGS19 Up-regulates Nm23-H1/2 Expression via Stimulating Multiple Transcriptional Factors


Li, Yuanjun; Wong, Yung Hou

RGS20 as a Modulator of Tumorigenesis and Angiogenesis


Leung, Man Hon Manton; Yang, Lei; Wong, Yung Hou
Article 10

A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity

International Journal of Molecular Sciences, v. 14, (9), September 2013, p. 18385-18406
Chan, King Hang; Wong, Yung Hou

Activation of Gαq subunits up-regulates the expression of the tumor suppressor Fhit

Cellular Signalling, v. 25, (12), December 2013, p. 2440-2452
Zuo, Hao; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou

Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor

Cell Communication and Signaling, v. 11, (1), August 2013, article number 59
Zuo, Hao; Chan, Grace P.W.; Zhu, Jing; Yeung, Wendy Wing Shan; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou

Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor

Current Medicinal Chemistry, v. 20, (2), January 2013, p. 289-300
Chan, King Hang; Hu, Sharry Y.; Ho, Maurice K C; Wong, Yung Hou

Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT2-selective melatonin agonists: Improving metabolic stability

Bioorganic and Medicinal Chemistry, v. 21, (2), January 2013, p. 547-552
Hu, Yueqing; Zhu, Jing; Chan, King Hang; Wong, Yung Hou

Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms

Cell Communication and Signaling, v. 11, (1), April 2013, article number 22
Lau, Winnie Wai In; Chan, Anthony Siu Lung; Poon, Lydia See Wing; Zhu, Jing; Wong, Yung Hou

Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells

British Journal of Pharmacology, v. 168, (3), February 2013, p. 746-760
Ng, Kai Yu; Yeung, Barry Ho Sing; Wong, Yung Hou; Wise, Helen

Neuronal Functions of Activators of G Protein Signaling

NeuroSignals, v. 21, (3-4), May 2013, p. 259-271
Tse, Man Kit; Wong, Yung Hou

Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis

Cancer Letters, v. 339, (1), October 2013, p. 33-41
Wang, Yingchun; Tong, Yao; Tso, Prudence H.; Wong, Yung Hou

RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras

Cellular Signalling, v. 25, (5), May 2013, p. 1064-1074
Tso, Ha Prudence; Wang, Yingchun; Yung, Ying Lisa; Tong, Yao; Lee, Mei Ki Maggie; Wong, Yung Hou
Book chapter 2

Development of novel melatoninergics as circadian rhythm sleep disorder therapeutics

New Developments in Melatonin Research / Editors: Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames. Nova Science Publishers, Inc., 2013, p. 53-76
Chan, King Hang; Cheung, Annie Suet Ting; Ho, Maurice K.C.; Wong, Yung Hou

High-throughput screening in traditional Chinese medicine-based drug discovery

Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds / Editors: Evandro Fei Fang, Tzi Bun Ng. Dordrecht : Springer Science+Business Media, 2013, p. 387-404
Wong, Catherine Chi Kit; Wong, Yung Hou
Conference paper 5

Nm23 Mediates RGS19-induced Suppression of Ras Signaling


Wong, Yung Hou

Regulation of STAT3 by GPCRs Involves Interleukin-6 Autocrine Signaling


Wong, Yung Hou

Sensory Neurons Regulate Toll-like Receptor 4 (TLR4) Signaling in Glia Derived from Dorsal Root Ganglia (DRG)


Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen

Toll-like Receptor 4 (TLR4) Differentially Regulates Cox-1 and Cox-2 to Enhance Prostanoid Production by Primary Sensory Neurons


Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen

Toll-like Receptor 4 (TLR4) Increases Expression of Inflammatory Mediators in Primary Sensory Neurons via Activation of a MyD88-dependent Signaling Pathway

Acta Pharmacologica Sinica, v. 34, July 2013, p. 116
Wise, Helen; Chow, Kevin Bing Shui; Tse, Kai Hei; Leung, Wai Keung; Wong, Yung Hou
Article 8

Activation of ras-dependent signaling pathways by G14-coupled receptors requires the adaptor protein TPR1

Journal of Cellular Biochemistry, v. 113, (11), November 2012, p. 3486-3497
Kwan, Dawna H.T.; Yung, Lisa Y.; Ye, Richard D.; Wong, Yung Hou

Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types

Planta Medica, v. 78, (2), January 2012, p. 115-121
Yung, Ying Lisa; Lam, Wing See; Ho, Maurice K.C.; Hu, Sharry Y.; Ip, Fanny C.F.; Pang, Haihong; Chin, Allison; Harley, Calvin B.; Ip, Nancy Yuk-yu; Wong, Yung Hou

CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα14/16 Signaling and IL-6 Release

Journal of Immunology, v. 189, (11), December 2012, p. 5266-5276
Lee, Mei Ki; Chui, Ricky K.S.; Tam, Issan Y.S.; Lau, Alaster H.Y.; Wong, Yung Hou

Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum

Molecular and Cellular Biochemistry, v. 362, (1-2), March 2012, p. 159-168
Ip, Angel K.C.; Tso, Ha; Lee, Mei Ki; Wong, Yung Hou

Interleukin-6 autocrine signaling mediates melatonin MT1/2 receptor-induced STAT3 Tyr705 phosphorylation

Journal of Pineal Research, v. 52, (4), May 2012, p. 477-489
Lau, Wai In; Ng, Johnson K.Y.; Lee, Mei Ki; Chan, Siu Lung Anthony; Wong, Yung Hou

Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats

Xenobiotica, v. 42, (11), November 2012, p. 1138-1150
Zhu, Jing; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou

Prostacyclin Receptor-Dependent Inhibition of Human Erythroleukemia Cell Differentiation is STAT3-Dependent

Prostaglandins Leukotrienes and Essential Fatty Acids, v. 86, (3), March 2012, p. 119-126
Lau, Alaster H.Y.; Lai, Henry K.H.; Yeung, Barry H.S.; Leung, Sze Lee; Tsang, Suk Ying; Wong, Yung Hou; Wise, Helen

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

Journal of Biological Chemistry, v. 287, (34), August 2012, p. 28362-28377
Hoffmann, Frauke; Mueller, Wiebke; Schuetz, Dagmar; Penfold, Mark E.; Wong, Yung Hou; Schulz, Stefan; Stumm, Ralf
Conference paper 3

Activated Gαq subunits interact with the tumor suppressor Fhit and increase its expression and phosphorylation

Stephenson Cancer Center Mini Conference on Tumor Microenvironment and Drug Discovery, 2-3 Dec 2012, Oklahoma, USA, Abstract T1
Wong, Yung Hou

Expression of Toll-like receptor 4 signaling components in adult rat dorsal root ganglion cells

Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 2012, p. 40
Tse, Kai Hei; Chow, Kevin Bing Shui; Ng, K. Y.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen

Novel interaction between signal transducing G proteins and the Fhit tumor suppressor

8th Asia Pacific Multidisciplinary Meeting for Cancer Research, May 11 2012, Hong Kong, Abstract T4
Wong, Yung Hou
Article 6

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties

Xenobiotica, v. 41, (1), January 2011, p. 35-45
Zhu, Jing; Hu, Yueqing; Ho, Maurice K.C.; Wong, Yung Hou

Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms

Cellular Signalling, v. 23, (11), November 2011, p. 1727-1737
Wan, Guoqiang; Zhou, Lihan; Lim, Qing `En; Wong, Yung Hou; Too, Heng-Phon

Expression of Gαz in C2C12 Cells Restrains Myogenic Differentiation

Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou

Glial cells isolated from dorsal root ganglia express prostaglandin E2 (EP4) and prostacyclin (IP) receptors

European Journal of Pharmacology, v. 661, (1-3), July 2011, p. 42-48
Ng, Kai Yu; Wong, Yung Hou; Wise, Helen

Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling

BMC Structural Biology, v. 11, April 2011, article number 17
Liu, A.M.F.; Lo, Kin H.; Guo, Emily X.; Ho, Maurice K.C.; Ye, Richard D.; Wong, Yung Hou

RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling

Cancer Letters, v. 309, (2), October 2011, p. 199-208
Tso, Prudence H.; Yung, Lisa Y.; Wang, Yingchun; Wong, Yung Hou
Book chapter 1

Regulation of Chemotaxis by Heterotrimeric G proteins

Chemotaxis: Types, Clinical Significance, and Mathematical Models / Edited by Timothy C. Williams. Hauppauge, N.Y.: Nova Science Publishers, c2011, p.109-134
Lee, Maggie M.K.; Wong, Yung Hou
Conference paper 4

Nm23-H1 inhibits oncogene-induced neoplastic transformation

Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U005
Tong, Yao; Wong, Yung Hou

Regulation of Fhit by Gq family proteins

Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U011
Zuo, H.; Chan, Anthony S.L.; Wong, Yung Hou

The expression of Toll-like receptor 4 in rat dorsal root ganglia

Annual Scientific Meeting of the Hong Kong Society of Immunology, Hong Kong, 7 May 2011
Chow, KB; Chu, TCH; Leung, WK; Wong, Yung Hou; Wise, Helen

Understanding the role of RGS20 in tumorigenesis

Second Inter-University Biochemistry Postgraduate Symposium, 11 Jun 2011, Hong Kong, Abstract P-U004
Yang, L.; Wong, Yung Hou
Article 9

Activation of STAT3 by specific Gα subunits and multiple Gβγ dimers

International Journal of Biochemistry and Cell Biology, v. 42, (6), June 2010, p. 1052-1059
Yuen, J.W.F.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Yu, Frances W.Y.; Lo, Kin H.; Wong, Yung Hou

Gα16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)

Cellular Signalling, v. 22, (10), October 2010, p. 1448-1458
Liu, A.M.F.; Lo, Kin H.; Lee, Mei Ki; Wang, Yingchun; Yeung, Wendy W.S.; Ho, Maurice K.C.; Su, Yan; Ye, Richard D.; Wong, Yung Hou

Gα16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling

Cellular Signalling, v. 22, (9), September 2010, p. 1379-1387
Yeung, Wing Shan; Wong, Yung Hou

In Search of Novel and Therapeutically Significant Melatoninergic Ligands

Frontiers in CNS Drug Discovery, v. 1, 2010, p. 600-610
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou

In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator

Drug Metabolism and Pharmacokinetics, v. 25, (5), November 2010, p. 477-486
Zhu, Jing; Lee, Stephanie; Ho, Maurice K.C.; Hu, Yueqing; Pang, Haihong; Ip, Fanny C.F.; Chin, Allison C.; Harley, Calvin B.; Ip, Nancy Yuk-Yu; Wong, Yung Hou

Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity

NeuroSignals, v. 18, (1), September 2010, p. 32-42
Yung, H.S.; Lai, K.H.; Chow, Kevin B.S.; Ip, Nancy Yuk-Yu; Tsim, Karl Wah Keung; Wong, Yung Hou; Wu, Zhenguo; Wise, Helen

RGS19 enhances cell proliferation through its C-terminal PDZ motif

Cellular Signalling, v. 22, (11), November 2010, p. 1700-1707
Tso, Ha; Wang, Yingchun; Wong, Sivia Y.S.; Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou

Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT2-selective melatonin ligands

Bioorganic and Medicinal Chemistry Letters, v. 20, (8), April 2010, p. 2582-2585
Hu, Yueqing; Ho, Kwok Chung Maurice; Chan, King Hang; New, David C.; Wong, Yung Hou

The role of glial cells in influencing neurite extension by dorsal root ganglion cells

Neuron Glia Biology, v. 6, (1), February 2010, p. 19-29
Ng, Kai-Yu; Wong, Yung Hou; Wise, Helen
Book chapter 1

Functional Impacts of Signal Integration: Regulation of Inflammation-related Transcription Factors by Heterotrimeric G Proteins

Molecular to Modular Tumor Therapy: Tumors are Reconstructible Communicatively Evolving Systems / Edited by Albrecht Reichle. Dordrecht: Springer Science+Business Media B.V., 2010, p.161-189
Yeung, Wing Shan; Ho, Maurice K.C.; Wong, Yung Hou
Conference paper 7

An investigation into the role of AGS3 in opiate tolerance and dependency

28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract PS13
Tse, Man Kit; Morris, Christina J.; Wong, Yung Hou

Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

Hong Kong Biochemistry Postgraduate Student Conference, 15 May 2010, Hong Kong, Abstract BCH10-A45
Hu, Sharry Y.; Ho, Maurice K.C.; Chan, King Hang; New, David C.; Wong, Yung Hou

Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

PepCon 2010, 20-22 March 2010, Beijing, China
Ho, Maurice K.C.; Hu, Sharry Y.; Chan, King Hang; Zhu, Jing; Wong, Yung Hou

Differential activation of G protein family members: GTPgammaS triggers subunit dissociation of Gi3 but not Gq.

28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, Yung Hou

Functional coupling of Melatonin receptors with G16 leads to independent phosphorylation of Tyr-705 and Ser-727 on STAT3

The 28th Hong Kong Society of Neuroscience (HKSN) Annual Meeting, 7-8 June 2010, Hong Kong, Abstract T6
Lau, Winnie W.I.; Chan, Anthony S.L.; Wong, Yung Hou

Melatonin MT1 receptor induces Fhit phosphorylation through the pertussis toxin-insensitive G16 protein

28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract T6
Zuo, H.; Chan, Siu Lung Anthony; Wong, Yung Hou

Structure-activity relationships of novel subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

28th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, 7-8 June 2010, Hong Kong, Abstract Y6
Chan, King Hang013378; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou
Article 11

A Hematopoietic Perspective on the Promiscuity and Specificity of Gα16 Signaling

NeuroSignals, v. 17, (1), February 2009, p. 71-81
Su, Yan; Ho, Maurice K.C.; Wong, Yung Hou

CCR1-mediated activation of nuclear factor-κB in THP-1 monocytic cells involves pertussis toxin-insensitive Gα14 and Gα16 signaling cascades

Journal of Leukocyte Biology, v. 86, (6), December 2009, p. 1319-1329
Lee, Mei Ki; Wong, Yung Hou

Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation

NeuroSignals, v. 17, (2), May 2009, p. 111-120
Ng, Yu Pong; Wu, Zhenguo; Wise, Helen; Tsim, Karl Wah Keung; Wong, Yung Hou; Ip, Nancy Yuk-Yu

G Protein signaling controls the differentiation of multiple cell lineages

BioFactors, v. 35, (3), May 2009, p. 232-238
Wang, Kepeng; Wong, Yung Hou

Gβ3 forms distinct dimers with specific Gγ subunits and preferentially activates the β3 isoform of phospholipase C

Cellular Signalling, v. 21, (5), May 2009, p. 737-744
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou

Multiple Gi Proteins Participate in Nerve Growth Factor-Induced Activation of c-Jun N-terminal Kinases in PC12 Cells

Neurochemical Research, v. 34, (6), June 2009, p. 1101-1112
Tso, Ha; Morris, Christina Jane; Yung, Ying; Ip, Nancy Yuk-Yu; Wong, Yung Hou

Multiplex fluorimetric assays for monitoring algal toxins

Journal of the Marine Biological Association of the United Kingdom, v. 89, (2), March 2009, p. 287-293
Mak, Carmen K.M.; Yeung, Patrick K.K.; Kwok, Chun Man; Wong, Yung Hou; Wong, Joseph T.Y.

Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells

Cell Biology International, v. 33, (2), February 2009, p. 230-238
Chan, Grace P.W.; Wu, Eddy H.T.; Wong, Yung Hou

Regulation of transcription factors by heterotrimeric G proteins

Current Molecular Pharmacology, v. 2, (1), 2009, p. 19-31
Ho, Maurice K.C.; Su, Yan; Yeung, Wing Shan; Wong, Yung Hou

Reporter Gene Assays

Methods in Molecular Biology (Clifton, N.J.), v. 486, 2009, p. 109-123
Liu, A.M.F.; New, David C.; Lo, Kin H.; Wong, Yung Hou

The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Gα16 and inhibits the canonical phospholipase Cβ pathway

Cellular Signalling, v. 21, (8), August 2009, p. 1317-1325
Yeung, Wing Shan; Wong, Yung Hou
Conference paper 20

Effect of cicaprost on differentiation of human erythroleukemia (HEL) cells

12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P10, 12-15 June 2009
Lai, K.H.; Lau, H.Y.A.; Tsang, Shui Ying; Wong, Yung Hou; Wise, H.

Effects of Activator of G-protein Signaling 3 upon K-Opioid Receptor Signaling

The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Tse, Man Kit; Wong, Yung Hou; Morris, Christina J.

GAIP inhibits Ras signaling and tumor formation

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-47, 11-15 January 2009
Wang, Y.; Tso, Ha; Wong, Yung Hou

Galphaq subunits interact with the Fhit tumor suppressor

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-40, 11-15 January 2009
Chan, G.P.W.; Chan, W.W.I.; Wong, Yung Hou

Galphaz-regulated myogenic and osteogenic differentiation of C2C12 cells

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-45, 11-15 January 2009
Wang, K.; Yung, Ying; Ho, Maurice K.C.; Wong, Yung Hou

GPCR signaling: role in cell proliferation and differentiation

12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract PL2, 12-15 June 2009
Wong, Yung Hou

Identification of Novel Binding Partners of GAIP

The 27th Annual Meeting of the Hong Kong Society of Neuroscience (HKSN), Hong Kong, China. January 11-15, 2009
Leung, Sing; Morris, Christina J.; Wong, Yung Hou

In vitro pharmacological characterizations of novel receptor subtype-spepcific melatoninergic ligands

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-39, 11-15 January 2009
Zhu, Jing; Ho, Maurice K.C.; Hu, Sharry Y.; Wong, Yung Hou

Melatonin MT1 and MT2 knockout mice exhibit impaired circadian rhythm re-entrainment

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-48, 11-15 January 2009
Xu, Y.; Ho, Maurice K.C.; Wong, Yung Hou

Melatonin MT1 Receptor-mediated PKD Activation

Gordon Research Conferences on Mechanisms Of Cell Signalling - Towards Understanding Signalling Networks, 23-28 August, Oxford, UK
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou

Melatonin MT2 receptor activates STAT3 through the pertussis toxin-insensitive G16 protein

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-39, 11-15 January 2009
Chan, Siu Lung Anthony; Lau, Wai In; Wong, Yung Hou

Molecular determinants for G betagamma-induced activation of phospholipase C-beta isoforms

The 6th Asian Biophysics Association Symposium & 27th Hong Kong Society of Neuroscience Annual Meeting
Poon, See Wing; Chan, Anthony S.L.; Wong, Yung Hou

Molecular determinants for Gbetagamma-induced activation of phospholipase C isoforms

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-46, 11-15 January 2009
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou

Prostanoid-stimulated cAMP production in rat dorsal root ganglion cells: role of non-neuronal cells

12th Scientific Meeting of the Hong Kong Pharmacology Society, Hong Kong, Abstract P6, 12-15 June 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen

RhoA-specific guanine nucleotide exchange factor p63RhoGEF modulates Galpha16 signaling

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS1-52, 11-15 January 2009
Yeung, Wing Shan; Wong, Yung Hou

Role of non-neuronal cells on influencing neurite extension by rat dorsal root ganglion cell neurons

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-23, 11-15 January 2009
Ng, K.Y.; Wong, Yung Hou; Wise, Helen

Role of PKC in melatonin receptor-mediated STAT3 activation

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract S16-7, 11-15 January 2009
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou

Structure-activity relationships of novel melatonin MT2 subtype-selective ligands with non-indoleamine scaffolds

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-44, 11-15 January 2009
Chan, S.K.H.; Ho, Maurice K.C.; Wong, Yung Hou

Targeting RGS proteins for the modulation of GPCR signaling

12th SCBA International Symposium, Taiwan, Abstract 7B-4, 14-18 June 2009
Wong, Yung Hou

TPR1 is required for Galphaq-mediated Ras signaling

27th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PS3-38, 11-15 January 2009
Kwan, D.H.T.; Liu, A.M.F.; Wong, Yung Hou
Article 6

Activation of the human FPRL-1 receptor promotes Ca2+ mobilization in U87 astrocytoma cells

Neurochemical Research, v. 33, (1), January 2008, p. 125-133
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou

Differential involvement of Gα16 in CC chemokine-induced stimulation of phospholipase Cβ, ERK, and chemotaxis

Cellular Signalling, v. 20, (6), June 2008, p. 1179-1189
Tian, Yaji; Lee, Maggie M.K.; Yung, Lisa Y.; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Wong, Yung Hou

Mutations on the switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors

Journal of Molecular Signaling, v. 3, November 2008, article number 17
Yu, May Y.M.; Ho, Maurice K.C.; Liu, A.M.F.; Wong, Yung Hou

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Current Medicinal Chemistry, v. 15, (25), October 2008, p. 2592-2613
Fu, Guangmiao; Pang, Haihong; Wong, Yung Hou

Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via Gi/o proteins

Cellular Signalling, v. 20, (8), August 2008, p. 1538-1544
Yung, Ying; Tso, Ha; Wu, Eddy H.T.; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou

Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Gαs and Gα16 hybrid signaling

Cellular Signalling, v. 20, (11), November 2008, p. 2095-2106
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou
Conference paper 8

AGS3 modulation of ERK phosphorylation by the kappa-opioid receptor

9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS21, 25-26 March 2008
Morris, Christina Jane; Wong, Yung Hou

AGS3 Modulation of ERK Phosphorylation by the Kappa-Opioid Receptor

The 39th Annual International Narcotics Research Conference (INRC), Charleston, SC. USA. July 13-18, 2008
Morris, Christina J.; Tse, Man Kit; Wong, Yung Hou

Formation of specific G protein Betagamma-dimers and their corresponding activation of phospholipase C isoforms

9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS24, 25-26 March 2008
Poon, Lydia See Wing; Chan, Siu Lung Anthony; Wong, Yung Hou

Galpha14 signaling through TPR1: a structural and functional perspective

9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS22, 25-26 March 2008
Kwan, D.H.T.; Wong, Yung Hou

GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells


Ho, Kwok Chung Maurice; Mei, Hua; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou

Influence of glial cells on stress-induced neurite retraction in rat dorsal root ganglion cells

APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Ng, K.Y.; Wong, Yung Hou; Wise, Helen

Melatonin MT1 receptor-mediated STAT3 activation through Galpha16

9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong., Abstract PPS25, 25-26 March 2008
Lau, Wai In; Chan, Siu Lung Anthony; Wong, Yung Hou

Nerve growth factor-induced differentiation of rat pheochromocytoma (PC12) cells leads to changes in adenylyl cyclase activity

APSN 2008, Shanghai, China, Abstract, 24-26 June 2008
Lai, K.H.; Yung, H.S.; Wong, Yung Hou; Wise, Helen
Article 8

Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress

Apoptosis, v. 12, (1), January 2007, p. 167-179
Chan, Siu Lung Anthony; Ng, Linda W.C.; Poon, Lydia See Wing; Chan, Winnie W.Y.; Wong, Yung Hou

Expression of G protein beta subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling

Neuroscience, v. 146, (2), May 2007, p. 594-603
Lok, Ka Chun; Fu, Amy Kit Yu; Ip, Fanny Chun Fun; Wong, Yung Hou; Ip, Nancy Yuk-Yu

Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1α in human U87 astrocytoma cells

Cellular Signalling, v. 19, (10), October 2007, p. 2106-2117
Kam, Angel Y.F.; Tse, Timothy T.M.; Kwan, Dawna H.T.; Wong, Yung Hou

Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-κB kinase in human U87 astrocytoma cells

Journal of Neurochemistry, v. 103, (4), November 2007, p. 1553-1566
Kam, Angel Y.F.; Liu, Andrew M.F.; Wong, Yung Hou

G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis

FEBS Journal, v. 274, (23), December 2007, p. 6025-6036
New, David C.; Wu, Kelvin; Kwok, Alice W.S.; Wong, Yung Hou

In search of novel and therapeutically significant melatoninergic ligands

Recent Patents on CNS Drug Discovery, v. 2, (3), November 2007, p. 241-245
Mody, Sejal M.; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou

Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression

Journal of Molecular Signaling, v. 2, February 2007, article number 2
New, David C.; Wong, Yung Hou

NRG induces membrane targeting of Gαz in muscle: implication in myogenesis

NeuroReport, v. 18, (14), September 2007, p. 1433-1436
Lok, Ka Chun; Fu, Kit Yu; Ip, Fanny C.F.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Conference paper 4

Adenylyl cyclase activity during NGF-induced differentiation of rat pheochromocytoma (PC12) cells

Croucher Advanced Study Institute on Movement Disorders: Basic and Clinical Sciences, Hong Kong., 27 November - 1 December 2007
Yung, H.S.; Lai, K.H.; Wong, Yung Hou; Wise, Helen

Drug Development Candidate TAT2 Activates Telomerase in Primary Neuronal Cultures


An, Hui Jin; Ip, Fanny C.F.; Hu, Sharry Y; Ho, Maurice K C; Chin, A.C.; Harley, C.B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu

Identification of subtype-selective melatonin receptor ligands from traditional Chinese medicine

MGH-HKU-Nature Forum. Molecular Medicine and Biopharma Opportunities, Hong Kong, 5-6 March 2007. Abstract P042.
Ho, Maurice K.C.; New, David C.; Hu, Sharry Y.; Pang, Haihong; Wong, Yung Hou

Knowledge-Based Drug Discovery: Identification of Novel Leads From Traditional Chinese Medicine


Pang, Haihong; Hu, Sharry Y.; Ho, Maurice K C; Ip, Fanny C.F.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou
Article 12

Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells

Cellular Signalling, v. 18, (3), March 2006, p. 258-293
Wu, Eddy H.T.; Wong, Yung Hou

Activation of STAT3 by Gαs Distinctively Requires Protein Kinase A, JNK, and Phosphatidylinositol 3-Kinase

Journal of Biological Chemistry, v. 281, (47), November 2006, p. 35812-35825
Liu, A.M.F.; Lo, Kin H.; Wong, Cecilia S.S.; Morris, Christina; Wise, Helen; Wong, Yung Hou

CKBM stimulates MAPKs but inhibits LPS-induced IFN-γ in lymphocytes

Phytotherapy Research, v. 20, (9), September 2006, p. 725-731
Chan, Siu Lung Anthony; Yip, Eric C.H.; Yung, Ying; Pang, Haihong; Luk, Sharon C.W.; Pang, Shin F.; Wong, Yung Hou

Constitutively active α subunits of Gq/11 and G2/13 families inhibit activation of the pro-survival Akt signaling cascade

FEBS Journal, v. 273, (11), June 2006, p. 2388-2398
Wu, Eddy H.T.; Tam, Becky H.L.; Wong, Yung Hou

GABAB heterodimeric receptors promote Ca2+ influx via store-operated channels in rat cortical neurons and transfected chinese hamster ovary cells

Neuroscience, v. 137, (4), 2006, p. 1347-1358
New, David C.; An, Hui Jin; Ip, Nancy Yuk-Yu; Wong, Yung Hou

Involvement of calcium mobilization from caffeine-sensitive stores in mechanically induced cell cycle arrest in the dinoflagellate Crypthecodinium cohnii

Cell Calcium, v. 39, (3), March 2006, p. 259-274
Yeung, Patrick Ka Kit; Lam, Connie Mo Ching; Ma, Zhiyi; Wong, Yung Hou; Wong, Joseph T.Y.

Opioid receptor-like (ORL1) receptor utilizes both G(0A) and G(0B) for signal transduction

Protein & Peptide Letters, v. 13, (5), May 2006, p. 437-441
Tso, Ha; Wong, Yung Hou

Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK

Cellular Signalling, v. 18, (3), March 2006, p. 307-317
Lo, Kin H.; Wise, Helen; Wong, Yung Hou

Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism

Cell Biology and Toxicology, v. 22, (4), July 2006, p. 293-302
Yip, E.C.H.; Chan, Siu Lung Anthony; Pang, Haihong; Tam, Y.K.; Wong, Yung Hou

The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-kappa B in Jurkat T-cells and THP-1 monocytic cells

American Journal of Chinese Medicine, v. 34, (2), 2006, p. 263-278
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou

Transcriptional activation of c-Fos by constitutively active Gα16QL through a STAT1-dependent pathway

Cellular Signalling, v. 18, (12), December 2006, p. 2143-2153
Lo, Kin H.; Wong, Yung Hou

Tuberin: A Stimulus-Regulated Tumor Suppressor Protein Controlled by a Diverse Array of Receptor Tyrosine Kinases and G Protein-Coupled Receptors

NeuroSignals, v. 15, (5), July 2006, p. 217-227
Wu, Eddy H.T.; Wu, Kelvin K.H.; Wong, Yung Hou
Book review 1

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity [Book review]

ChemMedChem, v. 1, (7), July 2006, p. 741-742
Wong, Yung Hou
Conference paper 15

A time-dependent loss of prostaglandin EP3 receptors in PC12 cells during neuroal differentiation

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Yung, H.S.; Wong, Yung Hou; Wise, Helen

Apoptosis of human neuroblastoma SK-N-MC cells induced by dopamine and norepinephrine

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, Siu Lung Anthony; Ng, L.W.C.; Poon, Lydia See Wing; Chan, W.W.Y.; Wong, Yung Hou

Axin Is Involved in Nerve Growth Factor-Induced Differentiation of PC12 Cells


Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu

Cell-based Fluorimetric assays for monitoring Gembierddiscus toxins

Proceedings of the Third International Conference on the Prevention and Management of Harmful Algal blooms in the South China Sea, p1-5. June, 2006. The Association on Harmful Algal Blooms in the South China Sea
Mak, Carmen K.M.; Yeung, Patrick K.K.; Wong, Yung Hou; Wong, Joseph T.Y.

Co-stimulation of Galphas alters Galpha16-mediated STAT3 activation.

Croucher Advanced Study Institute on Signaling in Cell Growth and Differentiation, Hong Kong, Abstract., 2006
Wong, Yung Hou

Ga sub(16) Binds to RhoA-Specific Guanine Nucleotide Exchange Factor p63RhoGEF and Competes with the Canonical PLC/PKC Pathway

46th Annual Meeting of the American Society for Cell Biology, San Diego Convention center, San Diego, California (USA), 9-13 Dec 2006
Yeung, W.W.S.; Wong, Yung Hou

Ga sub(s) Mediates b sub(2)-Adrenergic Receptor-Induced Stat3 Phosphorylation

4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Liu, A.M.F.; Lo, Kin H.; Wong, C.S.S.; Morris, Christina Jane; Wise, Helen; Wong, Yung Hou

Galpha14 interacts with tetratricopeptide repeat 1 for Ras signaling

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov ember 30 - December 2, 2006. Abstract.
Kwan, D.H.T.; Wong, Yung Hou

Galpha16 binds to RhoA-specific guanine nucleotide exchange factor p63RhoGEF and competes with the canonical PLC/PKC pathway

45th Annual Meeting of the American Society for Cell Biology, San Diego, USA, 13-17 December 2006. Abstract 67.
Yeung, Wing Shan; Wong, Yung Hou

Modulation of kappa-opioid signaling by RGS proteins

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Tso, Ha; Wong, Yung Hou

Opioid-induced pro-survival signals and the Akt/Tuberin pathway

Intl Narcotics Res Conf, Minnesota, USA, 9-14 July 2006, Abstract S II-5
Wong, Yung Hou

p63RhoGEF, a membrane-bound guanine nucleotide exchange factor, modulates signaling by heterotrimeric G proteins

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, Nov 30 - Dec 2, 2006, Abstract
Yeung, Wing Shan; Wong, Yung Hou

Regulatory mechanism of mTOR and p70 S6 kinase by muscarinic M4 receptors in PC12 cells

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS) & Annual Scientific Meeting of Hong Kong Society of Neurosciences, Hong Kong, November 30 - December 2, 2006. Abstract.
Chan, G.P.W.; Wu, Eddy H.T.; Wong, Yung Hou

Role of Axin in Nerve Growth Factor-Induced Differentiation of PC12 Cells


Ng, Yu Pong; Lin, Shengcai; Fu, Kit Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu

The down-regulation of prostaglandin EP3 receptor subtype during neuronal differentiation

IUPHAR 2006, Beijing, China, Abstract
Yung, H.S.; Wong, Yung Hou; Wise, Helen
Article 11

Activation of nuclear factor κB by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves Gα14 and multiple signaling components: A mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src

Journal of Biological Chemistry, v. 280, (41), October 2005, p. 34617-34625
Liu, A.M.F.; Wong, Yung Hou

Activation of δ-, κ-, and μ-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells

Biochemical and Biophysical Research Communications, v. 334, (3), September 2005, p. 838-844
Wu, Eddy H.T.; Wong, Yung Hou

An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity

Phytomedicine, v. 12, (10), November 2005, p. 748-759
Yip, Eric Chun Hung; Liu, A.M.F; Wong, Joseph T.Y.; Wong, Yung Hou

Carvacrol and eugenol differentially stimulate intracellular Ca2+ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells

Planta medica, v. 71, (7), July 2005, p. 634-639
Chan, Siu Lung Anthony; Pang, Haihong; Yip, Eric Chun Hung; Tam, Yunkau; Wong, Yung Hou

Chimeric and Promiscuous G Proteins in Drug Discovery and the Deorphanization of GPCRs

Drug Design Reviews Online, v. 2, (1), February 2005, p. 66-79
New, David C.; Wong, Yung Hou

Gq-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the Gs-Coupled Dopamine D1 Receptor in COS-7 Cells

Molecular Pharmacology, v. 68, (5), November 2005, p. 1354-1364
Chan, Siu Lung Anthony; Wong, Yung Hou

Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells

Biological and Pharmaceutical Bulletin, v. 28, (9), September 2005, p. 1645-1650
Chan, Siu Lung Anthony; Yip, Eric Chun Hung; Yung, Ying; Pang, Haihong; Luk, Sharon; Pang, Shiufun; Wong, Yung Hou

Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells

Journal of Neurochemistry, v. 94, (5), August 2005, p. 1457-1470
Chan, Siu Lung Anthony; Yeung, Wendy W.S.; Wong, Yung Hou

Involvement of Gi/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons

Molecular Pharmacology, v. 67, (4), April 2005, p. 1195-1205
Wu, Eddy H.T.; Wong, Yung Hou

Mu-Opioid Receptor-Mediated Phosphorylation of IκB Kinase in Human Neuroblastoma SH-SY5Y Cells

NeuroSignals, v. 14, (3), July 2005, p. 136-142
Liu, A.M.F.; Wong, Yung Hou

Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells

Cellular Signalling, v. 17, (7), July 2005, p. 881-890
Wu, Eddy H.T.; Wong, Yung Hou
Book chapter 1

Molecular Basis of Opioid Actions: Regulation of Mitogen-activated Protein Kinases

Recent Developments in Pain Research, 2005 / Edited by Anna Capasso. Research Signpost Publishers, 2005, p. 41-58
Chan, Siu Lung Anthony; New, David C.; Wong, Yung Hou
Conference paper 21

Activated Galpha11, Galpha12, and Galpha13 inhibit activation of the pro-survival AKT signaling cascade

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-25.
Tam, H.L.; Wu, Eddy H.T.; Wong, Yung Hou

Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract O-12.
Wu, Eddy H.T.; Wong, Yung Hou

Activation of the human FPRL-1 receptor promotes Ca2+ mobilization and stimulates mitogen-activated protein kinases in U87 astrocytoma cells.

25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-9., 2005
Kwan, Dawna H.T.; Kam, Angel Y.F.; Wong, Yung Hou

Differential regulation of signal transducers and activators of transcription by G protein subunits

24th Scientific Meeting of the Kong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-37.
Yuen, J.W.F.; Wong, Yung Hou

Expression profiling of Galphaz-regulated genes

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-23.
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou

Function of Galphaz in muscle differentiation

HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong., 10-12 March 2005
Mei, H.; Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou

G14-mediated stimulation of NFkappaB by the type 2 somatostatin receptor

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 13-14 January 2005, Abstract P-29
Liu, A.M.L.; Wong, Yung Hou

Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation


Xiao, Fang; Ng, Yu Pong; Tsim, Karl Wah Keung; Wise, Helen; Wong, Yung Hou; Ip, Nancy Yuk-Yu; Wu, Zhenguo

Involvement of Gi/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC12 cells

HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Wu, Eddy H.T.; Wong, Yung Hou

New perspectives in G protein signaling: regulation of protein kinases and transcription factors.

25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Plenary Lecture I., 2005
Wong, Yung Hou

NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.


Leung, W.K.W.; Choi, Chi Yan; Ip, Nancy Yuk-Yu; Wu, Zhenguo; Wong, Yung Hou; Cheung, P.T.; Tsim, Karl Wah Keung

Overexpression of Galphaz Inhibits Muscle Differentiation


Mei, Hua; Wu, Zhenguo; Ip, Nancy Yuk-Yu; Wong, Yung Hou

Regulation of STAT3 phosphorylation by Galphas.

25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong. Abstract P3., 2005
Lo, Kin H.; Liu, A.M.F.; Wise, Helen; Wong, Yung Hou

Role of Axin in Nerve Growth Factor-Stimulated Neurite Outgrowth


Ng, Yu Pong; Lin, Shengcai; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu

Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.


Kam, Yuet Fong; Yung, Ying; Wu, Eddy H.T.; Ng, Yu Pong; Wu, Zhenguo; Tsim, Karl Wah Keung; Wise, Helen; Ip, Nancy Yuk-Yu; Wong, Yung Hou

Screening for NMDA Receptor Antagonists Using Traditional Chinese Medicine


Ip, Fanny C.F.; An, Hui Jin; Chan, Agnes Wing Sze; Tong, Pui Sze; Hu, Sharry Y.; Wong, Yung Hou; Ip, Nancy Yuk-Yu

Stimulation of mitogen-activated protein kinases by the human FPRL-1 receptor

24th Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., 13-14 January 2005, Abstract P-27.
Kam, Angel Y.F.; Tse, T.T.M.; New, David C.; Wong, Yung Hou

Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells

24th Scientific Meeting of the Hong Kong Society of Neurosciences Hong Kong, 13-14 January 2005, Abstract P-33
Yeung, Wing Shan; Chan, Siu Lung Anthony; Wong, Yung Hou

Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells

HKU/HKUST/Cambridge University Joint Research Retreat, Hong Kong, 10-12 March 2005
Yeung, Wing Shan; Wong, Yung Hou

The effect of NGF-induced differentiation on the expression of prostanoid receptors in PC12 cells.

25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P-19., 2005
Yung, H.S.; Wong, Yung Hou; Wise, Helen

Unraveling chemokine signaling for drug discovery.

Pacifichem 2005, Hawaii, USA., 15-20 December 2005
Wong, Yung Hou
Article 12

Characterization of CHO cells stably expressing a Gα16/z Chimera for high throughput screening of GPCRs

Assay and Drug Development Technologies, v. 2, (3), June 2004, p. 269-280
New, David C.; Wong, Yung Hou

Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Gα14-coupled pathways

European Journal of Immunology, v. 34, (3), March 2004, p. 785-795
Tian, Yaji; New, David C.; Yung, Ying; Allen, Rodger A.; Slocombe, Patrick M.; Twomey, Breda M.; Lee, Mei Ki; Wong, Yung Hou

Epidermal growth factor differentially augments Gi-mediated stimulation of c-Jun N-terminal kinase activity

British Journal of Pharmacology, v. 142, (4), June 2004, p. 635-646
Chan, Siu Lung Anthony; Wong, Yung Hou

G16-mediated Activation of Nuclear Factor κB by the Adenosine A1 Receptor Involves c-Src, Protein Kinase C, and ERK Signaling

Journal of Biological Chemistry, v. 279, (51), December 2004, p. 53196-53204
Liu, A.M.F.; Wong, Yung Hou

Gβγ signaling and Ca2+ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by Gq-coupled receptors

Cellular Signalling, v. 16, (7), July 2004, p. 823-836
Chan, Siu Lung Anthony; Wong, Yung Hou

Identification of a stretch of six divergent amino acids on the α5 helix of Gα16 as a major determinant of the promiscuity and efficiency of receptor coupling

Biochemical Journal, v. 380, (2), June 2004, p. 361-369
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou

Phosphatidylinositol-3 kinase is distinctively required for μ-, but not κ-opioid receptor-induced activation of c-Jun N-terminal kinase

Journal of Neurochemistry, v. 89, (2), April 2004, p. 391-402
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou

Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2

Cellular Signalling, v. 16, (4), April 2004, p. 477-486
Chu, Kit-Man; Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen

Regulation of STAT3 by μ-opioid receptors in human neuroblastoma SH-SY5Ycells

NeuroReport, v. 15, (9), June 2004, p. 1431-1435
Yuen, Jessie W.F.; So, Ivy Y.W.; Kam, Angel Y.F.; Wong, Yung Hou

Replacement of the α5 helix of Gα16 with Gαs-specific sequences enhances promiscuity of Gα16 toward Gs-coupled receptors

Cellular Signalling, v. 16, (1), January 2004, p. 51-62
Hazari Anjali Ajaykumar; Lowes, Vicki L.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou

Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα14 Involves Multiple Intermediates

Molecular Pharmacology, v. 65, (6), June 2004, p. 1487-1439
Lo, Kin H.; Wong, Yung Hou

κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells

Journal of Pharmacology and Experimental Therapeutics, v. 310, (1), July 2004, p. 301-310
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou
Conference paper 6

Atypical regulation of calcium signals in astrocytoma 1321N1 cells expressing the purinergic P2Y12 receptor.

The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-15, 4-7 February
Ho, Maurice K.C.; Simon, J.; Barnard, E.A.; Wong, Yung Hou

Gi family members participate in nerve growth factor-mediated translational control in PC12 cells

Gordon Research Conference on Molecular & Cellular Neurobiology, Hong Kong, P65, 6-11 June
Wu, Eddy H.T.; Wong, Yung Hou

Opioid-mediated regulation of protein kinases and transcription factors

The 3rd Meeting of Asian Pacific Opioid Symposium on Molecular Basis of Opioid Tolerance and Dependence, Kyoto, Japan, 18 July 2004, Abstract
Wong, Yung Hou

Purinergic regulations of mitogen-activated protein kinases and calcium mobilization in rat brain capillary endothelial B10 cells

The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-12, 4-7 February
Wong, Yung Hou; Ho, Maurice K.C.; Leung, E.H.Y.; Simon, J.; Barnard, E.A.

Regulation of nuclear factor kappaB and STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells

Intl Narcotics Res Conf, Kyoto, Japan, 18-23 July 2004, Abstract P-52
Wong, Yung Hou; Liu, A.M.F.; Yuen, J.W.F.; Kam, A.Y.F.

Requirement of Gi/o proteins and phosphatidylinositol-3-kinase in nerve growth factor-induced tuberin phosphorylation and degradation

The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, Abstract B-P33-4, 4-7 February
Wu, Eddy H.T.; Wong, Yung Hou
Article 11

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates

FEBS Letters, v. 536, (1-3), February 2003, p. 157-160
New, David C.; Wong, Yung Hou

CC chemokine receptor-coupled signalling pathways

生物化学与生物物理学报=Acta Biochimica et Biophysica Sinica, v. 2003, (09), 2003, p. 779-788
New, David C.; Wong, Yung Hou

Constitutively Active Gα16 Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism

Journal of Biological Chemistry, v. 278, (52), December 2003, p. 52154-52165
Lo, Kin H.; Cheung, Helen; Wong, Yung Hou

G Protein-Linked Effector and Second Messenger Systems Involved in Melatonin Signal Transduction

NeuroSignals, v. 12, (2), March 2003, p. 59-70
New, David C.; Tsim, Siu T.; Wong, Yung Hou

Gα16/z chimeras efficiently link a wide range of G protein-coupled receptors to calcium mobilization

Journal of Biomolecular Screening, v. 8, (1), February 2003, p. 39-49
Liu, A.M.F.; Ho, Maurice K.C.; Wong, Cecilia S.S.; Chan, Jasmine H.P.; Pau, Anson H.M.; Wong, Yung Hou

Molecular basis of opioid dependence: Role of signal regulation by G-proteins

Clinical and Experimental Pharmacology and Physiology, v. 30, (5-6), May-June 2003, p. 307-316
Tso, Ha; Wong, Yung Hou

Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor

Journal of Neurochemistry, v. 84, (3), February 2003, p. 503-513
Kam, Angel Y.F.; Chan, Siu Lung Anthony; Wong, Yung Hou

Regulation of STAT3 activity by G16-coupled receptors

Biochemical and Biophysical Research Communications, v. 303, (3), April 2003, p. 920-925
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou

Reporter gene assays and their applications to bioassays of natural products

Phytotherapy Research, v. 17, (5), May 2003, p. 439-448
New, David C.; Miller-martini, David M.; Wong, Yung Hou

The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with G16

Journal of Neurochemistry, v. 87, (3), November 2003, p. 697-708
Chan, Anthony S.L.; Law, Ping Y.; Loh, Horace H.; Ho, Peter N.N.; Wu, Wai-Man; Chan, Joy S.C.; Wong, Yung Hou

The β6/α5 regions of Gαi2 and GαoA increase the promiscuity of Gα16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylation

European Journal of Pharmacology, v. 473, (2-3), July 2003, p. 105-115
Wong, Cecilia S.S.; Ho, Maurice K.C.; Wong, Yung Hou
Conference paper 6

Activation of STAT3 by hematopoietic-specific G proteins

10th Congress of Federation of Asian & Oceanian Biochemists and Molecular Biologists, India, Abstract S27, 7-11 December
Wong, Yung Hou; Lo, Kin H.

Constitutively active Galpha16 stimulates STAT1 via a c-Src/JAK- and ERK-dependent mechanism

43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 1573, 13-17 December
Lo, Kin H.; Wong, Yung Hou

Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced Akt signaling cascade in PC12 cells

23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract OP3, 9-10 December
Wu, E.H.T.; Wong, Yung Hou

Pertussis toxin-sensitive Gi/o proteins participate in nerve growth factor-induced activation of survival Akt kinase and nuclear factor kappaB

43rd Annual Meeting of the American Society for Cell Biology, San Francisco, USA, Abstract 67, 13-17 December
Wu, E.H.T.; Wong, Yung Hou

STAT3 activation by the delta-opioid receptor via Galpha14 involves c-Src/JAK- and ERK-dependent pathways

23rd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract PP9, 9-10 December
Lo, Kin H.; Wong, Yung Hou

The Roles of G-Proteins in the Formation of Neuromuscular Junction and Myogenesis


Lok, Ka Chun; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Article 9

Characterization and Channel Coupling of the P2Y12Nucleotide Receptor of Brain Capillary Endothelial Cells

Journal of Biological Chemistry, v. 277, (35), August 2002, p. 37390-31400
Simon, Joseph; Filippov, Alexander K.; Göransson, Sara A.; Wong, Yung Hou; Frelin, Christian; Michel, Anton D.; Brown, David A.; Barnard, Eric A.

Co-Expressions of Different Opioid Receptor Types Differentially Modulate Their Signaling via G16

NeuroSignals, v. 11, (2), March-April 2002, p. 115-122
Ho, Maurice K.C.; New, David C.; Wong, Yung Hou

Constitutive activation of the opioid receptor-like (ORL1) receptor by mutation of Asn133 to tryptophan in the third transmembrane region

Journal of Neurochemistry, v. 83, (6), December 2002, p. 1461-1470
Kam, Kenneth Wan Lung; New, David C.; Wong, Yung Hou

Integration of Signals from Receptor Tyrosine Kinases and G Protein-Coupled Receptors

NeuroSignals, v. 11, (1), January-February 2002, p. 5-19
Lowes, Vicki L.; Ip, Nancy Yuk-Yu; Wong, Ying Hou

Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins

Cellular Signalling, v. 14, (3), March 2002, p. 249-257
Chan, Siu Lung Anthony; Lai, Frank; Lo, Kin H.; Voyno-yasenetskaya, Tatyana A.; Stanbridge, Eric John; Wong, Yung Hou

Molecular determinants for the differential coupling of Gα16 to the melatonin MT1, MT2 and Xenopus Mel1c receptors

Journal of Neurochemistry, v. 80, (5), March 2002, p. 436-745
Lai, Frank; Mody, Sejal M.; Yung, Ying; Kam, Jason Y.M.; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou

Prostanoid Signal Integration and Cross Talk

NeuroSignals, v. 11, (1), January-February 2002, p. 20-28
Wise, Helen; Wong, Yung Hou; Jones, Robert Leslie

Signal Diversification by the Neuronal-Specific Gz Protein.

Neuro-Signals, 11: 170-171
Wong, Yung Hou

The ORL1 Receptor: Molecular Pharmacology and Signalling Mechanisms

NeuroSignals, v. 11, (4), July 2002, p. 197-212
New, David C.; Wong, Yung Hou
Book chapter 1

G protein structure diversity

Structure and Function of GPCRs in the Nervous System / 63-86
Ho, Maurice K.C.; Wong, Yung Hou
Conference paper 9

Atypical G protein signaling: The path to kinases

Croucher Advanced Study Institute on Cell Signaling and Gene Transcription, Croucher Foundation, Hong Kong, S2
Wong, Yung Hou

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor

22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P10
New, David C.; Wong, Yung Hou

Expressions of regulators of G protein signaling RGSZ1 and GAIP augment neuronal differentiation of PC12 cells

22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P12
Ho, Maurice K.C.; Wu, Eddy H.T.; Wong, Yung Hou

Involvement of G Protein Signaling Pathway at the Neuromuscular Junctions


Lok, Ka C.; Fu, Wing Yu; Wong, Yung Hou; Ip, Nancy Yuk-Yu

mu-Opioid receptor-mediated activation of c-Jun N-terminal kinase requires phosphatidylinositol 3-kinase

22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P13
Kam, Yuet Fong; Wong, Yung Hou

Nerve Growth Factor-Dependent Activation of C-Jun N-Terminal Kinase in PC12 Cells Is Mediated via Pertussis Toxin-Sensitive G Proteins


Tso, Ha; Yung, Ying; Yu, Jowie C.H.; Ip, Nancy Yuk-Yu; Wong, Yung Hou

Regulation of STAT3 activity by ORL1 receptor through Galpha16

22nd Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract O6
Wu, Eddy H.T.; Lo, Kin H.; Wong, Yung Hou

Signal diversification by the neuronal-specific Gz protein

Croucher Advanced Study Institute on Molecular Neuroscience Hong Kong University of Science and Technology
Wong, Yung Hou

The application of Galpha16/Z chimeras in high-throughput drug screening

Third International Symposium for Chinese Medicinal Chemists, Hong Kong, December
New, David C.; Ho, Maurice K.C.; Dai, Wei M.; Wong, Yung Hou
Article 9

A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine

Phytotherapy Research, v. 15, (6), September 2001, p. 487-492
Miller-martini, David M; Chan, Robbie Y.K.; Ip, Nancy Yuk-Yu; Sheu, S.J.; Wong, Yung Hou

Bacterial formyl peptide mediated chemotaxis and extracellular acidification in shrimp haemocytes

Developmental and Comparative Immunology, v. 25, (4), May 2001, p. 269-277
Yip, Eric Chun Hung; Wong, Yung Hou; Wong, Joseph T.Y.

Chimeric Gαq subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors

Journal of Pineal Research, v. 30, (3), April 2001, p. 171-179
Lai, Frank P.L.; Mody, Sejal M.; Yung, Ying; Pang, Celia Sook Fun; Pang, Shiufun; Wong, Yung Hou

Gz signaling: Emerging divergence from Gi signaling

Oncogene, v. 20, (13 REV. ISS. 1), March 2001, p. 1615-1625
Ho, Maurice K.C.; Wong, Yung Hou

Gα14 links a variety of Gi- and Gs-coupled receptors to the stimulation of phospholipase C

British Journal of Pharmacology, v. 132, (7), April 2001, p. 1431-1440
Ho, Maurice K.C.; Yung, Ying; Chan, Joy S.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou

Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than Gi1 and Gi3

Neuroscience Letters, v. 299, (1-2), February 2001, p. 25-28
Tso, Ha; Wong, Yung Hou

Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics

British Journal of Pharmacology, v. 134, (7), December 2001, p. 1375-1384
Chow, Kevin B.S.; Wong, Yung Hou; Wise, Helen

Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells

Neuroscience Letters, v. 316, (1), December 2001, p. 13-16
Tso, Ha; Wong, Yung Hou

The Cyclic AMP-Mediated Expression of Acetylcholinesterase in Myotubes Shows Contrasting Activation and Repression between Avian and Mammalian Enzymes

Molecular and Cellular Neuroscience, v. 17, (4), April 2001, p. 732-745
Choi, Roy Chi Yan; Siow, Nina Lam; Zhu, Shangquan; Wan, David Chi Cheong; Wong, Yung Hou; Tsim, Karl Wah Keung
Conference paper 10

Applications of chimeric and mutant Ga16 subunits in ligand screening for orphan G protein-coupled receptors.

7th Annual Conference of the Society for Biomolecular Screening, Baltimore, USA., Abstract 10012
Wong, Yung Hou; Ho, Maurice K.C.

Neuronal Gz protein differentially regulates mitogen-activated protein kinases and signal transducers and activators of transcription

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract P38
Ho, Maurice K.C.; Lo, Kin H.; Chan, Siu Lung Anthony; Tso, Ha; Wong, Yung Hou

Rac and Cdc42-dependent regulation of c-Jun N-terminal kinase by the opioid receptors.

International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong.
Kam, Angel Y.F.; Wong, Yung Hou

Regulation of STAT3 activity by heterotrimeric G proteins of the Gq subfamily.

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P26
Wong, Yung Hou; Lo, Kin H.; Ho, Maurice K.C.

Replacement of the C-terminal residues of Ga16 with Gai2 or Gao1 residues enhances its promiscuity for receptor recognition.

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P25
Wong, Cecilia S.S.; Pau, Anson H.M.; Wong, Yung Hou

Selected mutations in the a5 helix of Ga16 increase its promiscuity for receptors

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 37
Chan, Jasmine H.P.; Ho, Maurice K.C.; Wong, Yung Hou

Selected mutations of the a5 helix of Ga16 improves the coupling of Gi-linked receptor

International Symposium on Cell Signaling - from diseases to drug discovery, Hong Kong
Ho, Maurice K.C.; Chan, Jasmine H.P.; Wong, Cecilia S.S.; Wong, Yung Hou

Signaling from opioid receptors to c-Jun N-terminal kinase requires the small GTP-binding proteins Rac and Cdc42.

41st Annual Meeting of the American Society for Cell Biology, Washington, USA., Abstract 1233
Kam, Angel Y.F.; Wong, Yung Hou

Suppression of prostacyclin receptor-mediated phospholipase C stimulation by Ga14.

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong., Abstract P39
Lee, Mei Ki; Joshi, Sushma A.; Wise, Helen; Wong, Yung Hou

The regulation of c-Jun N-terminal kinase by opioid receptors involves Rac and Cdc42

21st Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, Abstract 24
Kam, Angel Y.F.; Wong, Yung Hou
Article 13

Activation of B-Raf and Regulation of the Mitogen-activated Protein Kinase Pathway by the Go α chain

Molecular Biology of the Cell, v. 11, (4), April 2000, p. 1129-1142
Antonelli, Valeria; Bernasconi, Francesca; Wong, Yung Hou; Vallar, Lucia

Cloning of a novel G-protein-coupled receptor from the sea anemone nervous system

Biochemical and Biophysical Research Communications, v. 271, (3), May 2000, p. 761-769
New, David C.; Wong, Yung Hou; Wong, Joseph T.Y.

Deciphering the role of Gi2 in opioid-induced adenylyl cyclase supersensitization

NeuroReport, v. 11, (14), September 2000, p. 3213-3217
Tso, Ha; Wong, Yung Hou

Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by Gz and G12 proteins

Cellular Signalling, v. 12, (7), July 2000, p. 481-489
Belcheva, Mariana M.; Wong, Yung Hou; Coscia, Carmine J.

Gz Can Mediate the Acute Actions of μ- and κ-Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization

Journal of Pharmacology and Experimental Therapeutics, v. 295, (1), October 2000, p. 168-176
Tso, Ha; Wong, Yung Hou

Immunoglobulin G1 Fc Fragment-Tagged Human Opioid Receptor-Like Receptor Retains the Ability to Inhibit cAMP Accumulation

Biological Signals and Receptors, v. 9, (5), September-October 2000, p. 240-247
Yung, Ying; Tsim, Karl Wah Keung; Pei, Gang; Wong, Yung Hou

Incorporation of Gαz-specific sequence at the carboxyl terminus increases the promiscuity of Gα16 toward Gi-coupled receptors

Molecular Pharmacology, v. 57, (1), January 2000, p. 13-23
Mody, Sejal M.; Ho, Maurice K.C.; Joshi, Sushma A.; Wong, Yung Hou

Molecular mechanisms and regulation of opioid receptor signaling

Annual Review of Pharmacology and Toxicology, v. 40, April 2000, p. 389-430
Law, Pingyee; Wong, Yung Hou; Loh, Horace

Preactivation Permits Subsequent Stimulation of Phospholipase C by G,sub>i-Coupled Receptors

Molecular Pharmacology, v. 57, (4), April 2000, p. 700-708
Chan, Joy S.C.; Lee, Jonathan W.M.; Ho, Maurice K.C.; Wong, Yung Hou

Regulation of Adenylyl Cyclase, ERK1/2, and CREB by Gz Following Acute and Chronic Activation of the δ-Opioid Receptor

Journal of Neurochemistry, v. 74, (4), April 2000, p. 1685-1693
Tso, Ha; Yung, Ying; Wong, Yung Hou

Regulation of C-jun N-terminal kinase by the ORL1 receptor through multiple G proteins

Journal of Pharmacology and Experimental Therapeutics, v. 295, (3), December 2000, p. 11094-1100
Chan, Siu Lung Anthony; Wong, Yung Hou

The Amino Terminus of Gαz is Required for Receptor Recognition, Whereas its α4/β6 Loop Is Essential for Inhibition of Adenylyl Cyclase

Molecular Pharmacology, v. 58, (5), November 2000, p. 993-1000
Ho, Maurice K.C.; Wong, Yung Hou

The Effect of Protein Kinase C Activation on Gz-Mediated Regulation of Type 2 and 6 Adenylyl Cyclases

Biological Signals and Receptors, v. 9, (1), January-February 2000, p. 21-28
Ho, Maurice K.C.; Chan, Joy S.C.; Yung, Ying; Wong, Yung Hou
Article 7

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex

NeuroReport, v. 10, (9), June 1999, p. 1993-1996
Ho, Maurice Kwok Chung; Wong, Yung Hou

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex

NeuroReport, v. 10, (7), May 1999, p. 1561-1564
Ho, Maurice K C; Wong, Yung Hou

Chronic activation of ORL1 receptor induces supersensitization of adenylyl cyclase

NeuroReport, v. 10, (14), September 1999, p. 2901-2905
Chan, Robbie; Wong, Yung Hou

Disruption of receptor-mediated activation of G protein by mutating a conserved arginine residue in the switch II region of the α subunit

Journal of Neurochemistry, v. 73, (5), November 1999, p. 2101-2109
Ho, Maurice K.C.; Yung, Ying; Wong, Yung Hou

GL1 (Gα14) couples the opioid receptor-like1 receptor to stimulation of phospholipase C

Journal of Pharmacology and Experimental Therapeutics, v. 288, (1), January 1999, p. 232-238
Yung, Ying; Joshi, Sushma A.; Chan, Robbie Y.K.; Chan, Joy S.C.; Pei, Gang; Wong, Yung Hou

Mutational analysis of the structure and function of opioid receptors

Biopolymers - Peptide Science Section, v. 51, (6), 1999, p. 440-455
Law, Pingyee; Wong, Yung Hou; Loh, Horace

Stimulation of phospholipase C by the cloned μ, δ and κ opioid receptors via chimeric Gαq mutants

European Journal of Neuroscience, v. 11, (2), January 1999, p. 383-388
Joshi, Sushma; Lee, Jonathan W.M.; Wong, Yung Hou
Article 8

Chimeric Gαq mutants harboring the last five carboxy-terminal residues of Gαi2 or Gαo are resistant to pertussis toxin-catalyzed ADP-ribosylation

FEBS Letters, v. 441, (1), December 1998, p. 67-70
Joshi, Sushma A.; Fan, Kenneth P.K.; Ho, Vannessa W.S.; Wong, Yung Hou

Differential coupling of μ-, δ-, and κ-opioid receptors to Gα16- mediated stimulation of phospholipase C

Journal of Neurochemistry, v. 70, (5), May 1998, p. 2203-2211
Lee, Jonathan W.M.; Joshi, Sushma A.; Chan, Joy S.C.; Wong, Yung Hou

Evidence for heterotrimeric G proteins in sea anemones

Molecular Marine Biology and Biotechnology, v. 7, (1), March 1998, p. 31-38
New, David C.; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y.

Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis

Journal of Pineal Research, v. 25, (4), December 1998, p. 219-228
Li, Lili; Xu, Jianning; Wong, Yung Hou; Wong, Joseph T.Y.; Pang, Shiufun; Shiu, Stephen Yuen Wing

Pertussis Toxin-Insensitive Signaling of the ORL1 Receptor: Coupling to Gz and G16 Proteins

Journal of Neurochemistry, v. 71, (5), November 1998, p. 2203-2210
Chan, Joy S.C.; Yung, Ying; Lee, Jonathan W.M.; Wu, Yalan; Pei, Gang; Wong, Yung Hou

Regulation of calcium influx and phospholipase C activity by indoleamines in dinoflagellate Crypthecodinium cohnii

Journal of Pineal Research, v. 24, (3), April 1998, p. 152-161
Tsim, Siu-Tai; Wong, Joseph T.Y.; Wong, Yung Hou

Structure and Function of the Pertussis-Toxin-Insensitive Gz Protein

Biological Signals and Receptors, v. 7, (2), March-April 1998, p. 80-89
Ho, Maurice K.C.; Wong, Yung Hou

The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP

Journal of Neurochemistry, v. 71, (1), July 1998, p. 152-160
Choi, Roy Chi Yan; Yung, Lisa Ying; Dong, Tina Ting Xia; Wan, David C.C.; Wong, Yung Hou; Tsim, Karl Wah Keung
Article 5

Calcium ion dependency and the role of inositol phosphates in melatonin-induced encystment of dinoflagellates

Journal of Cell Science, v. 110, (12), June 1997, p. 1387-1393
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou

Functional Role of Amino-Terminal Serine16 and Serine27 of Gαz in Receptor and Effector Coupling

Journal of Neurochemistry, v. 68, (6), June 1997, p. 2514-2522
Ho, Maurice K.C.; Wong, Yung Hou

Melatonin and 5-methoxytryptamine induced muscular contraction in sea anemones

Journal of Experimental Zoology, v. 279, (3), October 1997, p. 201-207
Tsang, Wai Hung; Mcgaughey Nicola Jane; Wong, Yung Hou; Wong, Joseph T.Y.

Receptor-induced βγ release from fatty acylation-deficient mutants of Gαz

NeuroReport, v. 8, (4), March 1997, p. 937-940
Beck, Helga I.; Chan, Joy S.C.; Wong, Yung Hou

Role of Amino- and Carboxyl-Terminal Regions of Gαz in the Recognition of Gi-Coupled Receptors

Molecular Pharmacology, v. 52, (1), July 1997, p. 38-45
Tsu Rachel Caroline; Ho, Maurice K.C.; Yung, Ying; Joshi, Sushma A.; Wong, Yung Hou
Article 6

CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin

Journal of Pineal Research, v. 21, (2), September 1996, p. 101-107
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou

Effects of Dibutyryl cAMP and Bacterial Toxins on Indoleamine-Induced Encystment of Dinoflagellates

Biological Signals, v. 5, (1), January-February 1996, p. 22-29
Tsim, Siu Tai; Wong, Joseph T.Y.; Wong, Yung Hou

Gi-mediated stimulation of type II adenylyl cyclase is augmented by Gq-coupled receptor activation and phorbol ester treatment

Journal of Neuroscience, v. 16, (4), February 1996, p. 1317-1323
Tsu, Rachel Caroline; Wong, Yung Hou

Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: Role of G protein and adenylyl cyclase activation

Molecular Pharmacology, v. 50, (6), December 1996, p. 1651-1657
Chiu, Tillie T.; Yung, Ying; Wong, Yung Hou

Possible involvement of G proteins in indoleamine-induced encystment in dinoflagellates

Molecular Marine Biology and Biotechnology, v. 5, (2), June 1996, p. 162-167
Tsim, Siu Tai; Yung, Ying; Wong, Joseph T.Y.; Wong, Yung Hou

The G Protein Linkage of Melatonin Receptors

Frontiers of Hormone Research, v. 21, 1996, p. 147-153
Wong, Yung Hou
Article 7

Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G Proteins

Journal of Neurochemistry, v. 65, (6), December 1995, p. 2682-2689
Chan, Joy S.C.; Chiu, Tillie T.; Wong, Yung Hou

Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive Gz protein

Biochemical Journal, v. 309, (1), July 1995, p. 331-339
Tsu, Rachel Caroline; Lai, H.W.L.; Allen, Rodger A.; Wong, Yung Hou

GZ coupling to the rat κ-opioid receptor

FEBS Letters, v. 360, (1), February 1995, p. 97-99
Lai, Helen W.L.; Minami, Masabumi; Satoh, Masamichi; Wong, Yung Hou

Mutant α subunit of G(z) transforms Swiss 3T3 cells

Oncogene, v. 10, (10), May 1995, p. 1927-1933
Wong, Yung Hou; Chan, Joy S.C.; Yung, Ying; Bourne, Henry R.

Regulation of multiple effectors by the cloned δ-opioid receptor: Stimulation of phospholipase C and type II adenylyl cyclase

Journal of Neurochemistry, v. 64, (6), June 1995, p. 2700-2707
Tsu, Rachel Caroline; Chan, Joy S.C.; Wong, Yung Hou

Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins

FEBS Letters, v. 372, (1), September 1995, p. 99-102
Yung, Ying; Tsim, Siu Tai; Wong, Yung Hou

Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors

Molecular Pharmacology, v. 47, (4), April 1995, p. 835-841
Tsu, Rachel Caroline; Allen, Rodger A.; Wong, Yung Hou
Article 2

Gi Assays in Transfected Cells

Methods in Enzymology, v. 238, (C), January 1994, p. 81-94
Wong, Yung Hou

Indolemine-induced encystment in dinoflagellates

J. Mar. Biol. Ass. U.K, v. 74, 1994, p. 467-469
Wong, J.T.Y.; Wong, Yung Hou
Article 4

Detection of Coincident Signals by G Proteins and Adenylyl Cyclase

Cold Spring Harbor Symposia on Quantitative Biology, v. 57, 1992, p. 145-148
Bourne, H.R.; Lustig, K.; Wong, Yung Hou; Conklin, B.R.

Gz-mediated hormonal inhibition of cyclic AMP accumulation

Science, v. 255, (5042), January 1992, p. 339-342
Wong, Yung Hou; Conklin, B.R.; Bourne, H.R.

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C

Journal of Biological Chemistry, v. 267, (1), January 1992, p. 31-34
Conklin, B.R.; Chabre, O.; Wong, Yung Hou; Federman, A.; Bourne, H.R.

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase

Journal of Biological Chemisty, v. 267, (29), October 1992, p. 20831-20834
Hung, D.T.; Wong, Yung Hou; Vu, T.K.; Coughlin, S.R.
Article 3

A mutant α subunit of Gi2 induces neoplastic transformation of rat-1 cells

Proceedings of the National Academy of Sciences of the United States of America, v. 88, (16), August 1991, p. 7031-7035
Pace, A.M.; Wong, Yung Hou; Barnard, E.A.

G protein oncogenes

In: Origins of Human Cancer: A Comprehensive Review, 1991, p. 327-333
Bourne, H.R.; Goretzki, P.; Landis, C.; Lyons, J.; McCormick, F.; Pace, A.; Wong, Yung Hou

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

Nature, v. 351, (6321), May 1991, p. 63-65
Wong, Yung Hou; Federman, Alex; Pace, Ann M.; Zachary, Ian; Evans, Tony; Pouysségur, Jacques; Bourne, Henry R.
Article 1

Agonist-selective protection of the opioid receptor-coupled G protein from inactivation by 5'-p-fluorosulphonylbenzoyl guanosine

Journal of Neurochemistry, v. 54, (1), January 1990, p. 39-45
Wong, Yung Hou; Demoliou-mason, C.D.; Hanley, M.R.; Barnard, E.A.
Article 3

Opioid receptor-G protein interactions: pertussis toxin, Li+ effects and reconstitution studies

Li+ effects and reconstitution studies. Adv. Biosci, v. 75, 1989, p. 153-156
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.

Opioid Receptors in Magnesium-Digitonin-Solubilized Rat Brain Membranes Are Tightly Coupled to a Pertussis Toxin-Sensitive Guanine Nucleotide-Binding Protein

Journal of Neurochemistry, v. 52, (4), April 1989, p. 0999-1009
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A.

Uncoupling of the opioid receptor-G protein complexes by 5'-p-fluorosulphonylbenzoyl guanosine

Adv. Biosci., v. 75, 1989, p. 133-136
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.
Article 2

A complex of opioid receptor with G protein, characterized in digitonin solution

In: Regulatory Roles of Opioid Peptides, Edited by Illes P and Farsang C. 1988, p. 131-144
Wong, Yung Hou; Demoliou-Mason, C.D.; Barnard, E.A.

ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes

Journal of Neurochemistry, v. 51, (1), July 1988, p. 114-121
Wong, Yung Hou; Demoliou-mason, C.D.; Barnard, E.A.
Article 1

Bradykinin stimulation of inositol phosphate and calcium responses is insensitive to pertussis toxin in NG115-401L neuronal cells

Biochemical and Biophysical Research Communications, v. 148, (1), October 1987, p. 412-416
Jackson, Trevor R.; Patterson, Sean I.; Wong, Yung Hou; Hanley, Michael R.
Article 1

Effects of hypoxaemia and hyperoxaemia on some cardiovascular responses of rats to adrenaline

Archives of Physiology and Biochemistry, v. 94, (5), 1986, p. 323-329
Dai, S.; Wong, Yung Hou; Ogle, C.W.
Article 1

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine

Pharmacology, v. 30, (6), 1985, p. 314-319
Dai, S.; Wong, Yung Hou
2017 8

RGS19 Upregulates Nm23-H1/2 Metastasis Suppressors by Transcriptional Activation via the cAMP/PKA/CREB Pathway

Oncotarget, v. 8, (41), July 2017, p. 69945-69960
Li, Yuanjun; Song, Jiaxing; Tong, Yao; Chung, Sookjakim; Wong, Yung Hou
Article

Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function

Molecules, v. 22, (7), July 2017, article number 1239
Leung, Ching Yiu Crystal; Wong, Yung Hou
Article

Activation of PKA-dependent transcription factors by RGS19 upregulates metastasis suppressor Nm23-H1/2.


Song, Jiaxing; Wong, Yung Hou
Conference paper

Back to the basics: the G protein cycle


Wong, Yung Hou; Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming
Conference paper

Differential G protein subunit dissociation mechanisms suggest possible family-wise selective Gβγ signaling


Liu, Wen; Li, Jiayue; Zhou, Longyin; Wong, Yung Hou
Conference paper

Functional characterization of heteromerization effects of melatonin receptors


Tse, Lap Hang; Ng, Siu Wang; Chan, King Hang; Wong, Yung Hou
Conference paper

Gq signaling pathway of melatonin receptor in islets of Langerhans


Gu, Yishan; Chan, Sze Man; Wong, Yung Hou
Conference paper

Transcriptional and post-transcriptional regulation of NME1 in cancer metastasis.


Wong, Yung Hou; Wong, Ka Ming
Conference paper
2016 9

Anxiety and Depression with Neurogenesis Defects in Exchange Protein Directly Activated by cAMP 2-Deficient Mice are Ameliorated by a Selective Serotonin Reuptake Inhibitor, Prozac

Translational Psychiatry, v. 6, (9), September 2016, article number e881
Zhou, L.; Ma, Sukling; Yeung, Patrick Ka Kit; Wong, Yung Hou; Tsim, Karl Wah Keung; So, K. F.; Lam, L.C.W.; Chung, S.K.
Article

Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by Gi- and Gq-Regulated Pathways

Journal of Molecular Biology, v. 428, (19), September 2016, p. 3869-3884
Chan, Anthony Siu Lung; Lau, Wai In; Szeto, Aydan C.H.; Wang, Jiuling; Wong, Yunghou
Article

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai
Article

Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species

Pharmaceutica Analytica Acta, v. 7, (4), April 2016, article number 1000474
Bi, Dan; Zhang, L.M.L.; Tang, Wai Lun; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Wong, Yung Hou; Lin, Huangquan; Tsim, Karl Wah Keung
Article

Regulator of G Protein Signaling 20 Enhances Cancer Cell Aggregation, Migration, Invasion and Adhesion

Cellular Signalling, v. 28, (11), November 2016, p. 1663-1672
Yang, Lei; Lee, Mei Ki; Leung, Man Hon Manton; Wong, Yung Hou
Article

Cdk5 Activity is Required for EphB-mediated Synaptogenesis


Chen, Yu; Wong, Yung Hou; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Conference paper

Flavonoids Induce the Expression of Acetylcholinesterase in Cultured Osteoblasts

Chemico-Biological Interactions, v. 259, (B), 25 November 2016, p. 295-300
Xu, Miranda Li; Bi, Wenchuan; Kong, Yeung Yeung Ava; Dong, Ting Xia; Wong, Yung Hou; Tsim, Karl Wah Keung
Conference paper

Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes


Wu, Y.; Chan, K.H.; Wong, Yung Hou
Conference paper

The role of RGS20 in cell cycle regulation and angiogenesis


Leung, M.; Alim, A.S.; Xu, R.; Wong, Yung Hou
Conference paper
2015 15

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gαi3

Molecular and Cellular Biochemistry, v. 401, (1-2), March 2015, p. 27-38
Tse, Man Kit; Morris, Christina Jane; Zhang, Mingjie; Wong, Yung Hou
Article

An intact helical domain is required for Gα14 to stimulate phospholipase Cβ

BMC Structural Biology, v. 15, (1), September 2015, article number 18
Kwan, Dawna HT; Wong, Ka Ming; Chan, Anthony Siu Lung; Yung, Lisa Ying; Wong, Yung Hou
Article

Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ

BMC Cancer, v. 15, (1), October 2015, article number 775
Zuo, Hao; Wong, Yung Hou
Article

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai
Article

Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis

Cancer Letters, v. 361, (2), June 2015, p. 207-217
Tong, Yao; Yung, Lisa Ying; Wong, Yung Hou
Article

Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives

Naunyn-Schmiedeberg's Archives of Pharmacology, v. 388, (2), February 2015, p. 243-256
Li, Yuanjun; Tong, Yao; Wong, Yung Hou
Article

RAS Genes

Encyclopedia of Cancer: a Springer Live Reference /Edited by Manfred Schwab. Berlin, Heidelberg : Springer, 2015, p. 1-6
Wong, Yung Hou; Pellicer, Angel; Liu, Wen
Book chapter

Activation Of Phospholipase Cβ By NonDissociable Gq Proteins


Wong, Yung Hou; Liu, W.; Chan, Siu Lung Anthony; Poon, Lydia See Wing; Wong, K.M.
Conference paper

Functional characterization of type 2 diabetes associated MTNRIB variants


Wu, Y.; Chan, K.H.; Wong, Yung Hou
Conference paper

Inhibition of oncogenic Ras-induced tumorigenesis by Nm23 metastasis suppressors


Wong, Y.H.; Li, Y.
Conference paper

Involvement of G proteins in asymmetric cell division during neurogenesis


Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou
Conference paper

Molecular determinants of selective ligand binding at the human melatonin receptor


Chan, King Hang; Wong, Yung Hou
Conference paper

Non-dissociable Gβ-Gα Fusion Proteins Reveal Different Mechanisms Of G Protein Activation


Liu, Wen; Chan, Siu Lung Anthony; Wong, Ka Ming; Wong, Yung Hou
Conference paper

Post-transcriptional regulation of the regulator of G protein signaling 19 (RGS19) and metastasis suppressor Nm23 in cancer by microRNAs


Wong, Ka Ming; Wong, Yung Hou
Conference paper

Role of surface residues on defining the functional specificity of Nm23 metastasis suppressors


Li, Yuanjun; Wong, Yung Hou
Conference paper
2014 11

Angiotensin-[1-12] interacts with angiotensin type I receptors

Neuropharmacology, v. 81, June 2014, p. 267-273
Chan, King Hang; Chen, Yi Hung; Zhang, Ying; Wong, Yung Hou; Dun, Nae J.
Article

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

NeuroSignals, v. 22, (1), May 2014, p. 52-63
Ip, Fanny Chui Fun; Ng, Yu Pong; An, Hui Jin; Dai, Ying; Pang, Hai Hong; Hu, Yue Qing; Chin, Allison C.; Harley, Calvin B.; Wong, Yung Hou; Ip, Nancy Yuk-Yu
Article

Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways

Neuroscience, v. 267, May 2014, p. 241-251
Tse, Kai Hei; Chow, K.B.S.; Leung, W.K.; Wong, Yung Hou; Wise, H.
Article

Primary Sensory Neurons Regulate Toll-like receptor-4-dependent Activity of Glial Cells in Dorsal Root Ganglia

Neuroscience, v. 279, October 2014, p. 10-22
Tse, Kai-Hei; Chow, K.B.S.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Article

Synthesis and Functional Characterization of Substituted Isoquinolinones as MT2-Selective Melatoninergic Ligands

PLoS ONE, v. 9, (12), December 2014, article number 0113638
Hu, Yueqing; Chan, King Hang; He, Xixin; Ho, Maurice Kwok Chung; Wong, Yung Hou
Article

Activation of Gq without Subunits Dissociation


Liu, Wen; Wong, Yung Hou
Conference paper

Activation of PLCβ by a Non-dissociable Gq Protein


Liu, W.; Chan, Siu Lung Anthony; Wong, K.M.; Wong, Yung Hou
Conference paper

ENStem - A Cells as a Model for Studying Neurogenesis


Yip, J.L.K.; Lee, M.M.K.; Wong, Yung Hou
Conference paper

Multi-faceted Metastasis Suppressor Nm23 is Up-regulated by RGS19 via Activating Transcription Factors


Li, Y.; Wong, Yung Hou
Conference paper

RGS19 Up-regulates Nm23-H1/2 Expression via Stimulating Multiple Transcriptional Factors


Li, Yuanjun; Wong, Yung Hou
Conference paper

RGS20 as a Modulator of Tumorigenesis and Angiogenesis


Leung, Man Hon Manton; Yang, Lei; Wong, Yung Hou
Conference paper
2013 17

A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity

International Journal of Molecular Sciences, v. 14, (9), September 2013, p. 18385-18406
Chan, King Hang; Wong, Yung Hou
Article

Activation of Gαq subunits up-regulates the expression of the tumor suppressor Fhit

Cellular Signalling, v. 25, (12), December 2013, p. 2440-2452
Zuo, Hao; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou
Article

Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor

Cell Communication and Signaling, v. 11, (1), August 2013, article number 59
Zuo, Hao; Chan, Grace P.W.; Zhu, Jing; Yeung, Wendy Wing Shan; Chan, Anthony Siu Lung; Ammer, Hermann; Wong, Yung Hou
Article

Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor

Current Medicinal Chemistry, v. 20, (2), January 2013, p. 289-300
Chan, King Hang; Hu, Sharry Y.; Ho, Maurice K C; Wong, Yung Hou
Article

Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT2-selective melatonin agonists: Improving metabolic stability

Bioorganic and Medicinal Chemistry, v. 21, (2), January 2013, p. 547-552
Hu, Yueqing; Zhu, Jing; Chan, King Hang; Wong, Yung Hou
Article

Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms

Cell Communication and Signaling, v. 11, (1), April 2013, article number 22
Lau, Winnie Wai In; Chan, Anthony Siu Lung; Poon, Lydia See Wing; Zhu, Jing; Wong, Yung Hou
Article

Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells

British Journal of Pharmacology, v. 168, (3), February 2013, p. 746-760
Ng, Kai Yu; Yeung, Barry Ho Sing; Wong, Yung Hou; Wise, Helen
Article

Neuronal Functions of Activators of G Protein Signaling

NeuroSignals, v. 21, (3-4), May 2013, p. 259-271
Tse, Man Kit; Wong, Yung Hou
Article

Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis

Cancer Letters, v. 339, (1), October 2013, p. 33-41
Wang, Yingchun; Tong, Yao; Tso, Prudence H.; Wong, Yung Hou
Article

RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras

Cellular Signalling, v. 25, (5), May 2013, p. 1064-1074
Tso, Ha Prudence; Wang, Yingchun; Yung, Ying Lisa; Tong, Yao; Lee, Mei Ki Maggie; Wong, Yung Hou
Article

Development of novel melatoninergics as circadian rhythm sleep disorder therapeutics

New Developments in Melatonin Research / Editors: Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames. Nova Science Publishers, Inc., 2013, p. 53-76
Chan, King Hang; Cheung, Annie Suet Ting; Ho, Maurice K.C.; Wong, Yung Hou
Book chapter

High-throughput screening in traditional Chinese medicine-based drug discovery

Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds / Editors: Evandro Fei Fang, Tzi Bun Ng. Dordrecht : Springer Science+Business Media, 2013, p. 387-404
Wong, Catherine Chi Kit; Wong, Yung Hou
Book chapter

Nm23 Mediates RGS19-induced Suppression of Ras Signaling


Wong, Yung Hou
Conference paper

Regulation of STAT3 by GPCRs Involves Interleukin-6 Autocrine Signaling


Wong, Yung Hou
Conference paper

Sensory Neurons Regulate Toll-like Receptor 4 (TLR4) Signaling in Glia Derived from Dorsal Root Ganglia (DRG)


Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Conference paper

Toll-like Receptor 4 (TLR4) Differentially Regulates Cox-1 and Cox-2 to Enhance Prostanoid Production by Primary Sensory Neurons


Tse, Kai Hei; Chow, Kevin Bing Shui; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Conference paper

Toll-like Receptor 4 (TLR4) Increases Expression of Inflammatory Mediators in Primary Sensory Neurons via Activation of a MyD88-dependent Signaling Pathway

Acta Pharmacologica Sinica, v. 34, July 2013, p. 116
Wise, Helen; Chow, Kevin Bing Shui; Tse, Kai Hei; Leung, Wai Keung; Wong, Yung Hou
Conference paper
2012 11

Activation of ras-dependent signaling pathways by G14-coupled receptors requires the adaptor protein TPR1

Journal of Cellular Biochemistry, v. 113, (11), November 2012, p. 3486-3497
Kwan, Dawna H.T.; Yung, Lisa Y.; Ye, Richard D.; Wong, Yung Hou
Article

Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types

Planta Medica, v. 78, (2), January 2012, p. 115-121
Yung, Ying Lisa; Lam, Wing See; Ho, Maurice K.C.; Hu, Sharry Y.; Ip, Fanny C.F.; Pang, Haihong; Chin, Allison; Harley, Calvin B.; Ip, Nancy Yuk-yu; Wong, Yung Hou
Article

CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα14/16 Signaling and IL-6 Release

Journal of Immunology, v. 189, (11), December 2012, p. 5266-5276
Lee, Mei Ki; Chui, Ricky K.S.; Tam, Issan Y.S.; Lau, Alaster H.Y.; Wong, Yung Hou
Article

Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum

Molecular and Cellular Biochemistry, v. 362, (1-2), March 2012, p. 159-168
Ip, Angel K.C.; Tso, Ha; Lee, Mei Ki; Wong, Yung Hou
Article

Interleukin-6 autocrine signaling mediates melatonin MT1/2 receptor-induced STAT3 Tyr705 phosphorylation

Journal of Pineal Research, v. 52, (4), May 2012, p. 477-489
Lau, Wai In; Ng, Johnson K.Y.; Lee, Mei Ki; Chan, Siu Lung Anthony; Wong, Yung Hou
Article

Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats

Xenobiotica, v. 42, (11), November 2012, p. 1138-1150
Zhu, Jing; Hu, Sharry Y.; Ho, Maurice K.C.; Wong, Yung Hou
Article

Prostacyclin Receptor-Dependent Inhibition of Human Erythroleukemia Cell Differentiation is STAT3-Dependent

Prostaglandins Leukotrienes and Essential Fatty Acids, v. 86, (3), March 2012, p. 119-126
Lau, Alaster H.Y.; Lai, Henry K.H.; Yeung, Barry H.S.; Leung, Sze Lee; Tsang, Suk Ying; Wong, Yung Hou; Wise, Helen
Article

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

Journal of Biological Chemistry, v. 287, (34), August 2012, p. 28362-28377
Hoffmann, Frauke; Mueller, Wiebke; Schuetz, Dagmar; Penfold, Mark E.; Wong, Yung Hou; Schulz, Stefan; Stumm, Ralf
Article

Activated Gαq subunits interact with the tumor suppressor Fhit and increase its expression and phosphorylation

Stephenson Cancer Center Mini Conference on Tumor Microenvironment and Drug Discovery, 2-3 Dec 2012, Oklahoma, USA, Abstract T1
Wong, Yung Hou
Conference paper

Expression of Toll-like receptor 4 signaling components in adult rat dorsal root ganglion cells

Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 2012, p. 40
Tse, Kai Hei; Chow, Kevin Bing Shui; Ng, K. Y.; Leung, Wai Keung; Wong, Yung Hou; Wise, Helen
Conference paper

Novel interaction between signal transducing G proteins and the Fhit tumor suppressor

8th Asia Pacific Multidisciplinary Meeting for Cancer Research, May 11 2012, Hong Kong, Abstract T4
Wong, Yung Hou
Conference paper
2011 11

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties

Xenobiotica, v. 41, (1), January 2011, p. 35-45
Zhu, Jing; Hu, Yueqing; Ho, Maurice K.C.; Wong, Yung Hou
Article

Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms

Cellular Signalling, v. 23, (11), November 2011, p. 1727-1737
Wan, Guoqiang; Zhou, Lihan; Lim, Qing `En; Wong, Yung Hou; Too, Heng-Phon
Article

Expression of Gαz in C2C12 Cells Restrains Myogenic Differentiation

Cellular Signalling, v. 23, (2), February 2011, p. 389-397
Mei, Hua; Ho, Kwok Chung Maurice; Yung, Ying; Wu, Zhenguo; Ip, Nancy Yuk-yu; Wong, Yung Hou
Article

Glial cells isolated from dorsal root ganglia express prostaglandin E2 (EP4) and prostacyclin (IP) receptors

European Journal of Pharm