Multi-target regulatory mechanism of Yang Xin Tang − a traditional Chinese medicine against dementia

Reconstructing Gαi1 into an effector-deficient mutant for the detection of receptor-activated Gβγ signals

CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1

Modeling The Heterodimer Interfaces Of Melatonin Receptors

Re-examining the ‘Dissociation Model’ of G protein activation from the perspective of Gβγ signaling

Allosteric modulations in signal transduction of the melatonin receptor heterodimer MT1/MT2

Nm23-H1 alters exosome content to abrogate pro-metastatic effect of breast cancer cell derived exosomes

Transcriptional targets of Nm23-H1 alter its metastasis suppressor function

Age Associated Decrease of MT-1 Melatonin Receptor in Human Dermal Skin Fibroblasts Impairs Protection Against UV-Induced DNA Damage

AGS3 and Gα_i3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells

Molecular basis defining the selectivity of substituted isoquinolinones for the melatonin MT₂ receptor

Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function

Anti-migratory effect of Nm23-H1 via exosomes

GPCRs in Autocrine and Paracrine Regulations

Small molecules as drugs to upregulate metastasis suppressors in cancer cells

Generation of an effector-deficient Gαi1

The role of leukemia inhibitory factor (LIF) in the intercellular communication between neurons and astrocytes. Abstract P48.

Unraveling the mechanism of RGS-induced upregulation of Nm23-H1. Abstract P68

MT1 and MT2 melatonin receptors: heteromerization and functional significance

Non-dissociable Gβ-Gα fusion proteins reveal different mechanisms of G protein activation

Regulation of metastasis suppressor genes mediated by breast cancer derived exosomes

RGS19 Upregulates Nm23-H1/2 Metastasis Suppressors by Transcriptional Activation via the cAMP/PKA/CREB Pathway

Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function

Activation of PKA-dependent transcription factors by RGS19 upregulates metastasis suppressor Nm23-H1/2.

Back to the basics: the G protein cycle

Differential G protein subunit dissociation mechanisms suggest possible family-wise selective Gβγ signaling

Functional characterization of heteromerization effects of melatonin receptors

Gq signaling pathway of melatonin receptor in islets of Langerhans

Transcriptional and post-transcriptional regulation of NME1 in cancer metastasis.

Anxiety and Depression with Neurogenesis Defects in Exchange Protein Directly Activated by cAMP 2-Deficient Mice are Ameliorated by a Selective Serotonin Reuptake Inhibitor, Prozac

Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by G_i^- and G_q^-Regulated Pathways

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species

Regulator of G Protein Signaling 20 Enhances Cancer Cell Aggregation, Migration, Invasion and Adhesion

Cdk5 Activity is Required for EphB-mediated Synaptogenesis

Flavonoids Induce the Expression of Acetylcholinesterase in Cultured Osteoblasts

Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes

The role of RGS20 in cell cycle regulation and angiogenesis

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα_i3

An intact helical domain is required for Gα₁₄ to stimulate phospholipase Cβ

Association of activated Gα_q to the tumor suppressor Fhit is enhanced by phospholipase Cβ

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis

Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives

RAS Genes

Activation Of Phospholipase Cβ By NonDissociable Gq Proteins

Functional characterization of type 2 diabetes associated MTNRIB variants

Inhibition of oncogenic Ras-induced tumorigenesis by Nm23 metastasis suppressors

Involvement of G proteins in asymmetric cell division during neurogenesis

Molecular determinants of selective ligand binding at the human melatonin receptor

Non-dissociable Gβ-Gα Fusion Proteins Reveal Different Mechanisms Of G Protein Activation

Post-transcriptional regulation of the regulator of G protein signaling 19 (RGS19) and metastasis suppressor Nm23 in cancer by microRNAs

Role of surface residues on defining the functional specificity of Nm23 metastasis suppressors

Angiotensin-[1-12] interacts with angiotensin type I receptors

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways

Primary Sensory Neurons Regulate Toll-like receptor-4-dependent Activity of Glial Cells in Dorsal Root Ganglia

Synthesis and Functional Characterization of Substituted Isoquinolinones as MT₂-Selective Melatoninergic Ligands

Activation of Gq without Subunits Dissociation

Activation of PLCβ by a Non-dissociable Gq Protein

ENStem - A Cells as a Model for Studying Neurogenesis

Multi-faceted Metastasis Suppressor Nm23 is Up-regulated by RGS19 via Activating Transcription Factors

RGS19 Up-regulates Nm23-H1/2 Expression via Stimulating Multiple Transcriptional Factors

RGS20 as a Modulator of Tumorigenesis and Angiogenesis

A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity

Activation of Gα_q subunits up-regulates the expression of the tumor suppressor Fhit

Activation state-dependent interaction between Gα_q subunits and the Fhit tumor suppressor

Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor

Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT₂-selective melatonin agonists: Improving metabolic stability

Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms

Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells

Neuronal Functions of Activators of G Protein Signaling

Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis

RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras

Development of novel melatoninergics as circadian rhythm sleep disorder therapeutics

High-throughput screening in traditional Chinese medicine-based drug discovery

Nm23 Mediates RGS19-induced Suppression of Ras Signaling

Regulation of STAT3 by GPCRs Involves Interleukin-6 Autocrine Signaling

Sensory Neurons Regulate Toll-like Receptor 4 (TLR4) Signaling in Glia Derived from Dorsal Root Ganglia (DRG)

Toll-like Receptor 4 (TLR4) Differentially Regulates Cox-1 and Cox-2 to Enhance Prostanoid Production by Primary Sensory Neurons

Toll-like Receptor 4 (TLR4) Increases Expression of Inflammatory Mediators in Primary Sensory Neurons via Activation of a MyD88-dependent Signaling Pathway

Activation of ras-dependent signaling pathways by G_14^-coupled receptors requires the adaptor protein TPR1

Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types

CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα_14/16 Signaling and IL-6 Release

Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum

Interleukin-6 autocrine signaling mediates melatonin MT_1/2 receptor-induced STAT3 Tyr⁷⁰⁵ phosphorylation

Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats

Prostacyclin Receptor-Dependent Inhibition of Human Erythroleukemia Cell Differentiation is STAT3-Dependent

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

Activated Gαq subunits interact with the tumor suppressor Fhit and increase its expression and phosphorylation

Expression of Toll-like receptor 4 signaling components in adult rat dorsal root ganglion cells

Novel interaction between signal transducing G proteins and the Fhit tumor suppressor

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties

Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms

Expression of Gα_z in C2C12 Cells Restrains Myogenic Differentiation

Glial cells isolated from dorsal root ganglia express prostaglandin E₂ (EP₄) and prostacyclin (IP) receptors

Gα₁₆ interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling

RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling

Regulation of Chemotaxis by Heterotrimeric G proteins

Nm23-H1 inhibits oncogene-induced neoplastic transformation

Regulation of Fhit by Gq family proteins

The expression of Toll-like receptor 4 in rat dorsal root ganglia

Understanding the role of RGS20 in tumorigenesis

Activation of STAT3 by specific Gα subunits and multiple Gβγ dimers

Gα₁₆ activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)

Gα₁₆ interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling

In Search of Novel and Therapeutically Significant Melatoninergic Ligands

In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator

Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity

RGS19 enhances cell proliferation through its C-terminal PDZ motif

Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT₂-selective melatonin ligands

The role of glial cells in influencing neurite extension by dorsal root ganglion cells

Functional Impacts of Signal Integration: Regulation of Inflammation-related Transcription Factors by Heterotrimeric G Proteins

An investigation into the role of AGS3 in opiate tolerance and dependency

Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

Characterization of subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

Differential activation of G protein family members: GTPgammaS triggers subunit dissociation of Gi3 but not Gq.

Functional coupling of Melatonin receptors with G16 leads to independent phosphorylation of Tyr-705 and Ser-727 on STAT3

Melatonin MT1 receptor induces Fhit phosphorylation through the pertussis toxin-insensitive G16 protein

Structure-activity relationships of novel subtype-selective melatoninergic ligands with novel non-indoleamine scaffolds

A Hematopoietic Perspective on the Promiscuity and Specificity of Gα₁₆ Signaling

CCR1-mediated activation of nuclear factor-κB in THP-1 monocytic cells involves pertussis toxin-insensitive Gα₁₄ and Gα₁₆ signaling cascades

Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation

G Protein signaling controls the differentiation of multiple cell lineages

Gβ₃ forms distinct dimers with specific Gγ subunits and preferentially activates the β₃ isoform of phospholipase C

Multiple G_i Proteins Participate in Nerve Growth Factor-Induced Activation of c-Jun N-terminal Kinases in PC12 Cells

Multiplex fluorimetric assays for monitoring algal toxins

Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells

Regulation of transcription factors by heterotrimeric G proteins

Reporter Gene Assays

The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Gα₁₆ and inhibits the canonical phospholipase Cβ pathway

Effect of cicaprost on differentiation of human erythroleukemia (HEL) cells

Effects of Activator of G-protein Signaling 3 upon K-Opioid Receptor Signaling

GAIP inhibits Ras signaling and tumor formation

Galphaq subunits interact with the Fhit tumor suppressor

Galphaz-regulated myogenic and osteogenic differentiation of C2C12 cells

GPCR signaling: role in cell proliferation and differentiation

Identification of Novel Binding Partners of GAIP

In vitro pharmacological characterizations of novel receptor subtype-spepcific melatoninergic ligands

Melatonin MT1 and MT2 knockout mice exhibit impaired circadian rhythm re-entrainment

Melatonin MT1 Receptor-mediated PKD Activation

Melatonin MT2 receptor activates STAT3 through the pertussis toxin-insensitive G16 protein

Molecular determinants for G betagamma-induced activation of phospholipase C-beta isoforms

Molecular determinants for Gbetagamma-induced activation of phospholipase C isoforms

Prostanoid-stimulated cAMP production in rat dorsal root ganglion cells: role of non-neuronal cells

RhoA-specific guanine nucleotide exchange factor p63RhoGEF modulates Galpha16 signaling

Role of non-neuronal cells on influencing neurite extension by rat dorsal root ganglion cell neurons

Role of PKC in melatonin receptor-mediated STAT3 activation

Structure-activity relationships of novel melatonin MT2 subtype-selective ligands with non-indoleamine scaffolds

Targeting RGS proteins for the modulation of GPCR signaling

TPR1 is required for Galphaq-mediated Ras signaling

Activation of the human FPRL-1 receptor promotes Ca²⁺ mobilization in U87 astrocytoma cells

Differential involvement of Gα₁₆ in CC chemokine-induced stimulation of phospholipase Cβ, ERK, and chemotaxis

Mutations on the switch III region and the alpha3 helix of Galpha₁₆ differentially affect receptor coupling and regulation of downstream effectors

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G_i/o proteins

Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Gα_s and Gα₁₆ hybrid signaling

AGS3 modulation of ERK phosphorylation by the kappa-opioid receptor

AGS3 Modulation of ERK Phosphorylation by the Kappa-Opioid Receptor

Formation of specific G protein Betagamma-dimers and their corresponding activation of phospholipase C isoforms

Galpha14 signaling through TPR1: a structural and functional perspective

GAlphaz Inhibits Myogenic Differentiation of C2C12 Cells

Influence of glial cells on stress-induced neurite retraction in rat dorsal root ganglion cells

Melatonin MT1 receptor-mediated STAT3 activation through Galpha16

Nerve growth factor-induced differentiation of rat pheochromocytoma (PC12) cells leads to changes in adenylyl cyclase activity

Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress

Expression of G protein beta subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling

Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1α in human U87 astrocytoma cells

Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-κB kinase in human U87 astrocytoma cells

G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis

In search of novel and therapeutically significant melatoninergic ligands

Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression

NRG induces membrane targeting of Gαz in muscle: implication in myogenesis

Adenylyl cyclase activity during NGF-induced differentiation of rat pheochromocytoma (PC12) cells

Drug Development Candidate TAT2 Activates Telomerase in Primary Neuronal Cultures

Identification of subtype-selective melatonin receptor ligands from traditional Chinese medicine

Knowledge-Based Drug Discovery: Identification of Novel Leads From Traditional Chinese Medicine

Activation of muscarinic M₄ receptor augments NGF-induced pro-survival Akt signaling in PC12 cells

Activation of STAT3 by Gα_s Distinctively Requires Protein Kinase A, JNK, and Phosphatidylinositol 3-Kinase

CKBM stimulates MAPKs but inhibits LPS-induced IFN-γ in lymphocytes

Constitutively active α subunits of G_q/11 and G_2/13 families inhibit activation of the pro-survival Akt signaling cascade

GABA_B heterodimeric receptors promote Ca²⁺ influx via store-operated channels in rat cortical neurons and transfected chinese hamster ovary cells

Involvement of calcium mobilization from caffeine-sensitive stores in mechanically induced cell cycle arrest in the dinoflagellate Crypthecodinium cohnii

Opioid receptor-like (ORL1) receptor utilizes both G(0A) and G(0B) for signal transduction

Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK

Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism

The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-kappa B in Jurkat T-cells and THP-1 monocytic cells

Transcriptional activation of c-Fos by constitutively active Gα₁₆QL through a STAT1-dependent pathway

Tuberin: A Stimulus-Regulated Tumor Suppressor Protein Controlled by a Diverse Array of Receptor Tyrosine Kinases and G Protein-Coupled Receptors

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity [Book review]

A time-dependent loss of prostaglandin EP3 receptors in PC12 cells during neuroal differentiation

Apoptosis of human neuroblastoma SK-N-MC cells induced by dopamine and norepinephrine

Axin Is Involved in Nerve Growth Factor-Induced Differentiation of PC12 Cells

Cell-based Fluorimetric assays for monitoring Gembierddiscus toxins

Co-stimulation of Galphas alters Galpha16-mediated STAT3 activation.

Ga sub(16) Binds to RhoA-Specific Guanine Nucleotide Exchange Factor p63RhoGEF and Competes with the Canonical PLC/PKC Pathway

Ga sub(s) Mediates b sub(2)-Adrenergic Receptor-Induced Stat3 Phosphorylation

Galpha14 interacts with tetratricopeptide repeat 1 for Ras signaling

Galpha16 binds to RhoA-specific guanine nucleotide exchange factor p63RhoGEF and competes with the canonical PLC/PKC pathway

Modulation of kappa-opioid signaling by RGS proteins

Opioid-induced pro-survival signals and the Akt/Tuberin pathway

p63RhoGEF, a membrane-bound guanine nucleotide exchange factor, modulates signaling by heterotrimeric G proteins

Regulatory mechanism of mTOR and p70 S6 kinase by muscarinic M4 receptors in PC12 cells

Role of Axin in Nerve Growth Factor-Induced Differentiation of PC12 Cells

The down-regulation of prostaglandin EP3 receptor subtype during neuronal differentiation

Activation of nuclear factor κB by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves Gα₁₄ and multiple signaling components: A mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src

Activation of δ-, κ-, and μ-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells

An aqueous extract of the popular Chinese nutraceutical Kwei Ling Ko (Tortoise shell-Rhizome Jelly) activates the PPARγ pathway and down-regulates the NFκB activity

Carvacrol and eugenol differentially stimulate intracellular Ca²⁺ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells

Chimeric and Promiscuous G Proteins in Drug Discovery and the Deorphanization of GPCRs

G_q-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the G_s-Coupled Dopamine D₁ Receptor in COS-7 Cells

Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells

Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells

Involvement of G_i/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons

Mu-Opioid Receptor-Mediated Phosphorylation of IκB Kinase in Human Neuroblastoma SH-SY5Y Cells

Pertussis toxin-sensitive G_i/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells

Molecular Basis of Opioid Actions: Regulation of Mitogen-activated Protein Kinases

Activated Galpha11, Galpha12, and Galpha13 inhibit activation of the pro-survival AKT signaling cascade

Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells

Activation of the human FPRL-1 receptor promotes Ca2+ mobilization and stimulates mitogen-activated protein kinases in U87 astrocytoma cells.

Differential regulation of signal transducers and activators of transcription by G protein subunits

Expression profiling of Galphaz-regulated genes

Function of Galphaz in muscle differentiation

G14-mediated stimulation of NFkappaB by the type 2 somatostatin receptor

Identification of Critical Early Genes Involved in Nerve Growth Factor-Induced PC12 Differentiation

Involvement of Gi/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC12 cells

New perspectives in G protein signaling: regulation of protein kinases and transcription factors.

NGF-Induced Neuronal Differentiation of PC12 Cells: Delineation of Signaling Molecules and Mapping of Pathways.

Overexpression of Galphaz Inhibits Muscle Differentiation

Regulation of STAT3 phosphorylation by Galphas.

Role of Axin in Nerve Growth Factor-Stimulated Neurite Outgrowth

Role of Calmodulin-Dependent Kinase II in Nerve Growth Factor-Induced Differentiation of PC12 Cells.

Screening for NMDA Receptor Antagonists Using Traditional Chinese Medicine

Stimulation of mitogen-activated protein kinases by the human FPRL-1 receptor

Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells

Synergistic activation of extracellular signal-regulated kinase by Gi- and Gq-coupled receptors in SK-N-MC neuroepithelioma cells

The effect of NGF-induced differentiation on the expression of prostanoid receptors in PC12 cells.

Unraveling chemokine signaling for drug discovery.

Characterization of CHO cells stably expressing a Gα_16/z Chimera for high throughput screening of GPCRs

Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Gα₁₄-coupled pathways

Epidermal growth factor differentially augments G_i-mediated stimulation of c-Jun N-terminal kinase activity

G₁₆-mediated Activation of Nuclear Factor κB by the Adenosine A₁ Receptor Involves c-Src, Protein Kinase C, and ERK Signaling

Gβγ signaling and Ca²⁺ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by G_q-coupled receptors

Identification of a stretch of six divergent amino acids on the α5 helix of Gα₁₆ as a major determinant of the promiscuity and efficiency of receptor coupling

Phosphatidylinositol-3 kinase is distinctively required for μ-, but not κ-opioid receptor-induced activation of c-Jun N-terminal kinase

Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2

Regulation of STAT3 by μ-opioid receptors in human neuroblastoma SH-SY5Ycells

Replacement of the α5 helix of Gα₁₆ with Gα_s-specific sequences enhances promiscuity of Gα₁₆ toward G_s-coupled receptors

Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα₁₄ Involves Multiple Intermediates

κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells

Atypical regulation of calcium signals in astrocytoma 1321N1 cells expressing the purinergic P2Y12 receptor.

Gi family members participate in nerve growth factor-mediated translational control in PC12 cells

Opioid-mediated regulation of protein kinases and transcription factors

Purinergic regulations of mitogen-activated protein kinases and calcium mobilization in rat brain capillary endothelial B10 cells

Regulation of nuclear factor kappaB and STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells

Requirement of Gi/o proteins and phosphatidylinositol-3-kinase in nerve growth factor-induced tuberin phosphorylation and degradation

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB₂ receptor: signalling via cAMP and inositol phosphates

CC chemokine receptor-coupled signalling pathways

Constitutively Active Gα₁₆ Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism

G Protein-Linked Effector and Second Messenger Systems Involved in Melatonin Signal Transduction

Gα_16/z chimeras efficiently link a wide range of G protein-coupled receptors to calcium mobilization

Molecular basis of opioid dependence: Role of signal regulation by G-proteins

Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor

Regulation of STAT3 activity by G₁₆-coupled receptors

Reporter gene assays and their applications to bioassays of natural products

The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with G₁₆

The β6/α5 regions of Gα_i2 and Gα_oA increase the promiscuity of Gα₁₆ but are insufficient for pertussis toxin-catalyzed ADP-ribosylation

Activation of STAT3 by hematopoietic-specific G proteins

Constitutively active Galpha16 stimulates STAT1 via a c-Src/JAK- and ERK-dependent mechanism

Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced Akt signaling cascade in PC12 cells

Pertussis toxin-sensitive Gi/o proteins participate in nerve growth factor-induced activation of survival Akt kinase and nuclear factor kappaB

STAT3 activation by the delta-opioid receptor via Galpha14 involves c-Src/JAK- and ERK-dependent pathways

The Roles of G-Proteins in the Formation of Neuromuscular Junction and Myogenesis

Characterization and Channel Coupling of the P2Y₁₂Nucleotide Receptor of Brain Capillary Endothelial Cells

Co-Expressions of Different Opioid Receptor Types Differentially Modulate Their Signaling via G₁₆

Constitutive activation of the opioid receptor-like (ORL₁) receptor by mutation of Asn133 to tryptophan in the third transmembrane region

Integration of Signals from Receptor Tyrosine Kinases and G Protein-Coupled Receptors

Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins

Molecular determinants for the differential coupling of Gα₁₆ to the melatonin MT1, MT2 and Xenopus Mel1c receptors

Prostanoid Signal Integration and Cross Talk

Signal Diversification by the Neuronal-Specific Gz Protein.

The ORL₁ Receptor: Molecular Pharmacology and Signalling Mechanisms

G protein structure diversity

Atypical G protein signaling: The path to kinases

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor

Expressions of regulators of G protein signaling RGSZ1 and GAIP augment neuronal differentiation of PC12 cells

Involvement of G Protein Signaling Pathway at the Neuromuscular Junctions

mu-Opioid receptor-mediated activation of c-Jun N-terminal kinase requires phosphatidylinositol 3-kinase

Nerve Growth Factor-Dependent Activation of C-Jun N-Terminal Kinase in PC12 Cells Is Mediated via Pertussis Toxin-Sensitive G Proteins

Regulation of STAT3 activity by ORL1 receptor through Galpha16

Signal diversification by the neuronal-specific Gz protein

The application of Galpha16/Z chimeras in high-throughput drug screening

A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine

Bacterial formyl peptide mediated chemotaxis and extracellular acidification in shrimp haemocytes

Chimeric Gα_q subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors

G_z signaling: Emerging divergence from G_i signaling

Gα₁₄ links a variety of G_i- and G_s-coupled receptors to the stimulation of phospholipase C

Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G_i1 and G_i3

Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics

Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells

The Cyclic AMP-Mediated Expression of Acetylcholinesterase in Myotubes Shows Contrasting Activation and Repression between Avian and Mammalian Enzymes

Applications of chimeric and mutant Ga16 subunits in ligand screening for orphan G protein-coupled receptors.

Neuronal Gz protein differentially regulates mitogen-activated protein kinases and signal transducers and activators of transcription

Rac and Cdc42-dependent regulation of c-Jun N-terminal kinase by the opioid receptors.

Regulation of STAT3 activity by heterotrimeric G proteins of the Gq subfamily.

Replacement of the C-terminal residues of Ga16 with Gai2 or Gao1 residues enhances its promiscuity for receptor recognition.

Selected mutations in the a5 helix of Ga16 increase its promiscuity for receptors

Selected mutations of the a5 helix of Ga16 improves the coupling of Gi-linked receptor

Signaling from opioid receptors to c-Jun N-terminal kinase requires the small GTP-binding proteins Rac and Cdc42.

Suppression of prostacyclin receptor-mediated phospholipase C stimulation by Ga14.

The regulation of c-Jun N-terminal kinase by opioid receptors involves Rac and Cdc42

Activation of B-Raf and Regulation of the Mitogen-activated Protein Kinase Pathway by the G_o α chain

Cloning of a novel G-protein-coupled receptor from the sea anemone nervous system

Deciphering the role of G_i2 in opioid-induced adenylyl cyclase supersensitization

Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G_z and G₁₂ proteins

G_z Can Mediate the Acute Actions of μ- and κ-Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization

Immunoglobulin G1 Fc Fragment-Tagged Human Opioid Receptor-Like Receptor Retains the Ability to Inhibit cAMP Accumulation

Incorporation of Gα_z-specific sequence at the carboxyl terminus increases the promiscuity of Gα₁₆ toward G_i-coupled receptors

Molecular mechanisms and regulation of opioid receptor signaling

Preactivation Permits Subsequent Stimulation of Phospholipase C by G,sub>i-Coupled Receptors

Regulation of Adenylyl Cyclase, ERK1/2, and CREB by G_z Following Acute and Chronic Activation of the δ-Opioid Receptor

Regulation of C-jun N-terminal kinase by the ORL₁ receptor through multiple G proteins

The Amino Terminus of Gα_z is Required for Receptor Recognition, Whereas its α4/β6 Loop Is Essential for Inhibition of Adenylyl Cyclase

The Effect of Protein Kinase C Activation on G_z-Mediated Regulation of Type 2 and 6 Adenylyl Cyclases

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex

Alanine-23 of transducin α subunit is involved in defining the affinity for βγ complex

Chronic activation of ORL₁ receptor induces supersensitization of adenylyl cyclase

Disruption of receptor-mediated activation of G protein by mutating a conserved arginine residue in the switch II region of the α subunit

G_L1 (Gα₁₄) couples the opioid receptor-like₁ receptor to stimulation of phospholipase C

Mutational analysis of the structure and function of opioid receptors

Stimulation of phospholipase C by the cloned μ, δ and κ opioid receptors via chimeric Gα_q mutants

Chimeric Gα_q mutants harboring the last five carboxy-terminal residues of Gα_i2 or Gα_o are resistant to pertussis toxin-catalyzed ADP-ribosylation

Differential coupling of μ-, δ-, and κ-opioid receptors to Gα₁₆- mediated stimulation of phospholipase C

Evidence for heterotrimeric G proteins in sea anemones

Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis

Pertussis Toxin-Insensitive Signaling of the ORL₁ Receptor: Coupling to G_z and G₁₆ Proteins

Regulation of calcium influx and phospholipase C activity by indoleamines in dinoflagellate Crypthecodinium cohnii

Structure and Function of the Pertussis-Toxin-Insensitive G_z Protein

The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP

Calcium ion dependency and the role of inositol phosphates in melatonin-induced encystment of dinoflagellates

Functional Role of Amino-Terminal Serine¹⁶ and Serine²⁷ of Gα_z in Receptor and Effector Coupling

Melatonin and 5-methoxytryptamine induced muscular contraction in sea anemones

Receptor-induced βγ release from fatty acylation-deficient mutants of Gα_z

Role of Amino- and Carboxyl-Terminal Regions of G_αz in the Recognition of G_i-Coupled Receptors

CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin

Effects of Dibutyryl cAMP and Bacterial Toxins on Indoleamine-Induced Encystment of Dinoflagellates

G_i-mediated stimulation of type II adenylyl cyclase is augmented by G_q-coupled receptor activation and phorbol ester treatment

Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: Role of G protein and adenylyl cyclase activation

Possible involvement of G proteins in indoleamine-induced encystment in dinoflagellates

The G Protein Linkage of Melatonin Receptors

Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G Proteins

Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive G_z protein

GZ coupling to the rat κ-opioid receptor

Mutant α subunit of G(z) transforms Swiss 3T3 cells

Regulation of multiple effectors by the cloned δ-opioid receptor: Stimulation of phospholipase C and type II adenylyl cyclase

Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through G_i and G_z proteins

Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors

Indolemine-induced encystment in dinoflagellates

G_i Assays in Transfected Cells

Detection of Coincident Signals by G Proteins and Adenylyl Cyclase

Gz-mediated hormonal inhibition of cyclic AMP accumulation

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase

A mutant α subunit of G_i2 induces neoplastic transformation of rat-1 cells

G protein oncogenes

Mutant α subunits of G_i2 inhibit cyclic AMP accumulation

Agonist-selective protection of the opioid receptor-coupled G protein from inactivation by 5'-p-fluorosulphonylbenzoyl guanosine

Opioid receptor-G protein interactions: pertussis toxin, Li+ effects and reconstitution studies

Opioid Receptors in Magnesium-Digitonin-Solubilized Rat Brain Membranes Are Tightly Coupled to a Pertussis Toxin-Sensitive Guanine Nucleotide-Binding Protein

Uncoupling of the opioid receptor-G protein complexes by 5'-p-fluorosulphonylbenzoyl guanosine

A complex of opioid receptor with G protein, characterized in digitonin solution

ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes

Bradykinin stimulation of inositol phosphate and calcium responses is insensitive to pertussis toxin in NG115-401L neuronal cells

Effects of hypoxaemia and hyperoxaemia on some cardiovascular responses of rats to adrenaline

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine

RGS19 Upregulates Nm23-H1/2 Metastasis Suppressors by Transcriptional Activation via the cAMP/PKA/CREB Pathway

Article

Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function

Article

Activation of PKA-dependent transcription factors by RGS19 upregulates metastasis suppressor Nm23-H1/2.

Conference paper

Back to the basics: the G protein cycle

Conference paper

Differential G protein subunit dissociation mechanisms suggest possible family-wise selective Gβγ signaling

Conference paper

Functional characterization of heteromerization effects of melatonin receptors

Conference paper

Gq signaling pathway of melatonin receptor in islets of Langerhans

Conference paper

Transcriptional and post-transcriptional regulation of NME1 in cancer metastasis.

Conference paper

Anxiety and Depression with Neurogenesis Defects in Exchange Protein Directly Activated by cAMP 2-Deficient Mice are Ameliorated by a Selective Serotonin Reuptake Inhibitor, Prozac

Article

Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by G_i^- and G_q^-Regulated Pathways

Article

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

Article

Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species

Article

Regulator of G Protein Signaling 20 Enhances Cancer Cell Aggregation, Migration, Invasion and Adhesion

Article

Cdk5 Activity is Required for EphB-mediated Synaptogenesis

Conference paper

Flavonoids Induce the Expression of Acetylcholinesterase in Cultured Osteoblasts

Conference paper

Functional assessment of MT2 melatonin receptor variants that are associated with type 2 diabetes

Conference paper

The role of RGS20 in cell cycle regulation and angiogenesis

Conference paper

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα_i3

Article

An intact helical domain is required for Gα₁₄ to stimulate phospholipase Cβ

Article

Association of activated Gα_q to the tumor suppressor Fhit is enhanced by phospholipase Cβ

Article

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Article

Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis

Article

Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives

Article

RAS Genes

Book chapter

Activation Of Phospholipase Cβ By NonDissociable Gq Proteins

Conference paper

Functional characterization of type 2 diabetes associated MTNRIB variants

Conference paper

Inhibition of oncogenic Ras-induced tumorigenesis by Nm23 metastasis suppressors

Conference paper

Involvement of G proteins in asymmetric cell division during neurogenesis

Conference paper

Molecular determinants of selective ligand binding at the human melatonin receptor

Conference paper

Non-dissociable Gβ-Gα Fusion Proteins Reveal Different Mechanisms Of G Protein Activation

Conference paper

Post-transcriptional regulation of the regulator of G protein signaling 19 (RGS19) and metastasis suppressor Nm23 in cancer by microRNAs

Conference paper

Role of surface residues on defining the functional specificity of Nm23 metastasis suppressors

Conference paper

Angiotensin-[1-12] interacts with angiotensin type I receptors

Article

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

Article

Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways

Article

Primary Sensory Neurons Regulate Toll-like receptor-4-dependent Activity of Glial Cells in Dorsal Root Ganglia

Article

Synthesis and Functional Characterization of Substituted Isoquinolinones as MT₂-Selective Melatoninergic Ligands

Article

Activation of Gq without Subunits Dissociation

Conference paper

Activation of PLCβ by a Non-dissociable Gq Protein

Conference paper

ENStem - A Cells as a Model for Studying Neurogenesis

Conference paper

Multi-faceted Metastasis Suppressor Nm23 is Up-regulated by RGS19 via Activating Transcription Factors

Conference paper

RGS19 Up-regulates Nm23-H1/2 Expression via Stimulating Multiple Transcriptional Factors

Conference paper

RGS20 as a Modulator of Tumorigenesis and Angiogenesis

Conference paper

A Molecular and Chemical Perspective in Defining Melatonin Receptor Subtype Selectivity

Article

Activation of Gα_q subunits up-regulates the expression of the tumor suppressor Fhit

Article

Activation state-dependent interaction between Gα_q subunits and the Fhit tumor suppressor

Article

Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor

Article

Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT₂-selective melatonin agonists: Improving metabolic stability

Article

Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms

Article

Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells

Article

Neuronal Functions of Activators of G Protein Signaling

Article

Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis

Article

RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras

Article

Development of novel melatoninergics as circadian rhythm sleep disorder therapeutics

Book chapter

High-throughput screening in traditional Chinese medicine-based drug discovery

Book chapter

Nm23 Mediates RGS19-induced Suppression of Ras Signaling

Conference paper

Regulation of STAT3 by GPCRs Involves Interleukin-6 Autocrine Signaling

Conference paper

Sensory Neurons Regulate Toll-like Receptor 4 (TLR4) Signaling in Glia Derived from Dorsal Root Ganglia (DRG)

Conference paper

Toll-like Receptor 4 (TLR4) Differentially Regulates Cox-1 and Cox-2 to Enhance Prostanoid Production by Primary Sensory Neurons

Conference paper

Toll-like Receptor 4 (TLR4) Increases Expression of Inflammatory Mediators in Primary Sensory Neurons via Activation of a MyD88-dependent Signaling Pathway

Conference paper

Activation of ras-dependent signaling pathways by G_14^-coupled receptors requires the adaptor protein TPR1

Article

Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types

Article

CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα_14/16 Signaling and IL-6 Release

Article

Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum

Article

Interleukin-6 autocrine signaling mediates melatonin MT_1/2 receptor-induced STAT3 Tyr⁷⁰⁵ phosphorylation

Article

Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats

Article

Prostacyclin Receptor-Dependent Inhibition of Human Erythroleukemia Cell Differentiation is STAT3-Dependent

Article

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

Article

Activated Gαq subunits interact with the tumor suppressor Fhit and increase its expression and phosphorylation

Conference paper

Expression of Toll-like receptor 4 signaling components in adult rat dorsal root ganglion cells

Conference paper

Novel interaction between signal transducing G proteins and the Fhit tumor suppressor