Faculty Profiles - HIRANO Yukinori | The Hong Kong University of Science and Technology

Yukinori HIRANO
平野恭敬

DSc in Biological Science
Nagoya University, 2008

Associate Professor
Division of Life Science

(852) 2358 8031
yukinori@ust.hk
Room 5505A
Personal Web

Google Scholar

aShbWDcAAAAJ

ORCID

0000-0003-3313-637X

ResearcherID

M-6473-2018

Scopus ID

7202721983

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Molecular and cellular neuroscience
Aging
Neuroscience

Publications

All Years 24 2024 1 2023 3 2022 2 2021 1 2020 1 2019 1 2018 15

2024 1

The CoREST complex regulates multiple histone modifications temporal-specifically in clock neurons

Open Biology, v. 14, (7), July 2024, article number 230355, p. 1-13
Lv, Pengfei; Zhao, Zhangwu; Hirano, Yukinori; Du, Juan
Article

2023 3

Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention

Proceedings of the National Academy of Sciences of the United States of America, v. 120, (36), September 2023, article number e2304851120
Takakura, Mai; Lam, Yu Hong; Nakagawa, Reiko; Ng, Man Yung; Hu, Xinyue; Bhargava, Priyanshu; Alia, Abdalla Galaa Mohamed; Gu, Yuzhe; Wang, Zigao; Ota, Takeshi; Kimura, Yoko; Morimoto, Nao; Osakada, Fumitaka; Lee, Ah Young; Leung, Chi Yeu; Miyashita, Tomoyuki; Du, Juan; Okuno, Hiroyuki; Hirano, Yukinori
Article

Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention

Hirano, Yukinori
Conference paper

Neuro-glial basis of phobia development

Alia, Abdalla Galaa Mohamed; Hu, Xinyue; Hirano, Yukinori
Conference paper

2022 2

A neuronal cell-based reporter system for monitoring the activity of HDAC2

SLAS Discovery, v. 27, (8), December 2022, p. 440-447
Unemura, Kazuhiro; Kawano, Masako; Takakura, Mai; Iwata, Ikuko; Hyakkoku, Kana; Horiguchi, Naotaka; Okuda, Tomohiko; Hirano, Yukinori
Article

転写活性の時間的制御を介した記憶のアップデート機構

生化学=Seikagaku, v. 94, (6), 2022, p. 905-909
平野恭敬
Article

2021 1

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila

Nature Communications, v. 12, (1), 27 January 2021, article number 628
Takakura, Mai; Nakagawa, Reiko; Ota, Takeshi; Kimura, Yoko; Ng, Man Yung; Alia, Abdalla Galaa Mohamed; Okuno, Hiroyuki; Hirano, Yukinori
Article

2020 1

Optimization of Light-Inducible Gal4/UAS Gene Expression System in Mammalian Cells

iScience, v. 23, (9), 25 September 2020, article number 101506
Yamada, Mayumi; Nagasaki, Shinji C.; Suzuki, Yusuke; Hirano, Yukinori; Imayoshi,Itaru
Article

2019 1

The neural circuit linking mushroom body parallel circuits induces memory consolidation in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (32), 6 August 2019, p. 16080-16085
Awata, Hiroko; Takakura, Mai; Kimura, Yoko; Iwata, Ikuko; Masuda, Tomoko; Hirano, Yukinori
Article

2016 1

Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies

Nature Communications, v. 7, 14 November 2016, article number 13471
Hirano, Yukinori; Ihara, Kunio; Masuda, Tomoko; Yamamoto, Takuya; Iwata, Ikuko; Takahashi, Aya; Awata, Hiroko; Nakamura, Naosuke; Takakura, Mai; Suzuki, Yusuke; Horiuchi, Junjiro; Okuno, Hiroyuki; Saitoe, Minoru
Article

2015 1

Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication

PLoS Genetics, v. 11, (8), 11 August 2015, article number e1005283
Goto, Greicy H.; Zencir, Sevil; Hirano, Yukinori; Ogi, Hiroo; Ivessa, Andreas; Sugimoto, Katsunori
Article

2014 2

Glial dysfunction causes age-related memory impairment in Drosophila

Neuron, v. 84, (4), November 2014, p. 753-763
Yamazaki, Daisuke; Horiuchi, Junjiro; Ueno, Kohei; Ueno, Taro; Saeki, Shinjiro; Matsuno, Motomi; Naganos, Shintaro; Miyashita, Tomoyuki; Hirano, Yukinori; Nishikawa, Hiroyuki; Taoka, Masato; Yamauchi, Yoshio; Isobe, Toshiaki; Honda, Yoshiko; Kodama, Tohru; Masuda, Tomoko; Saitoe, Minoru
Article

空腹による脳機能制御

日常生活の脳科学=Brain and Nerve, v. 66, (1), January 2014, p. 41-48
平野恭敬; 齊藤実
Article

2013 3

Fasting launches CRTC to facilitate long-term memory formation in Drosophila

Science, v. 339, (6118), 25 January 2013, p. 443-446
Hirano, Yukinori; Masuda, Tomoko; Naganos, Shintaro; Matsuno, Motomi; Ueno, Kohei; Miyashita, Tomoyuki; Horiuchi, Junjiro; Saitoe, Minoru
Article

Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger

Communicative & Integrative Biology, v. 6, (5), 4 June 2013
Hirano, Yukinori; Saitoe, Minoru
Article

Long-term enhancement of synaptic transmission between antennal lobe and mushroom body in cultured Drosophila brain

Journal of Physiology, v. 591, (1), January 2013, p. 287-302
Ueno, Kohei; Naganos, Shintaro; Hirano, Yukinori; Horiuchi, Junjiro; Saitoe, Minoru
Article

2012 2

Reactive oxygen species are not involved in the onset of age-related memory impairment in Drosophila

Genes, Brain and Behavior, v. 11, (1), February 2012, p. 79-86
Hirano, Yukinori; Kuriyama, Y.; Miyashita, T.; Horiuchi, J.; Saitoe, M.
Article

Subtelomere-binding protein Tbf1 and telomerebinding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast

Molecular Biology of the Cell, v. 23, (2), 15 January 2012, p. 347-359
Fukunaga, Kenzo; Hirano, Yukinori; Sugimoto, Katsunori
Article

2009 2

Rif1 and Rif2 Inhibit Localization of Tel1 to DNA Ends

Molecular Cell, v. 33, (3), 13 February 2009, p. 312-322
Hirano, Yukinori; Fukunaga, Kenzo; Sugimoto, Katsunori
Article

Role of budding yeast Rad18 in repair of HO-induced double-strand breaks

DNA Repair, v. 8, (1), 2009, p. 51-59
Hirano, Yukinori; Reddy, Jayant; Sugimoto, Katsunori
Article

2007 1

Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends

Molecular Biology of the Cell, v. 18, (6), June 2007, p. 2026-2036
Hirano, Yukinori; Sugimoto, Katsunori
Article

2006 1

ATR homolog Mec1 controls association of DNA polymerase ζ-Rev1 complex with regions near a double-strand break

Current Biology, v. 16, (6), 21 March 2006, p. 586-590
Hirano, Yukinori; Sugimoto, Katsunori
Article

2005 1

Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage

Molecular Biology of the Cell, v. 16, (11), November 2005, p. 5227-5235
Nakada, Daisuke; Hirano, Yukinori; Tanaka, Yuya; Sugimoto, Katsunori
Article

2004 1

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

Molecular and Cellular Biology, v. 24, (22), November 2004, p. 10016-10025
Nakada, Daisuke; Hirano, Yukinori; Sugimoto, Katsunori
Article

Article 1

The CoREST complex regulates multiple histone modifications temporal-specifically in clock neurons

Open Biology, v. 14, (7), July 2024, article number 230355, p. 1-13
Lv, Pengfei; Zhao, Zhangwu; Hirano, Yukinori; Du, Juan

Article 1

Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention

Proceedings of the National Academy of Sciences of the United States of America, v. 120, (36), September 2023, article number e2304851120
Takakura, Mai; Lam, Yu Hong; Nakagawa, Reiko; Ng, Man Yung; Hu, Xinyue; Bhargava, Priyanshu; Alia, Abdalla Galaa Mohamed; Gu, Yuzhe; Wang, Zigao; Ota, Takeshi; Kimura, Yoko; Morimoto, Nao; Osakada, Fumitaka; Lee, Ah Young; Leung, Chi Yeu; Miyashita, Tomoyuki; Du, Juan; Okuno, Hiroyuki; Hirano, Yukinori

Conference paper 2

Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention

Hirano, Yukinori

Neuro-glial basis of phobia development

Alia, Abdalla Galaa Mohamed; Hu, Xinyue; Hirano, Yukinori

Article 2

A neuronal cell-based reporter system for monitoring the activity of HDAC2

SLAS Discovery, v. 27, (8), December 2022, p. 440-447
Unemura, Kazuhiro; Kawano, Masako; Takakura, Mai; Iwata, Ikuko; Hyakkoku, Kana; Horiguchi, Naotaka; Okuda, Tomohiko; Hirano, Yukinori

転写活性の時間的制御を介した記憶のアップデート機構

生化学=Seikagaku, v. 94, (6), 2022, p. 905-909
平野恭敬

Article 1

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila

Nature Communications, v. 12, (1), 27 January 2021, article number 628
Takakura, Mai; Nakagawa, Reiko; Ota, Takeshi; Kimura, Yoko; Ng, Man Yung; Alia, Abdalla Galaa Mohamed; Okuno, Hiroyuki; Hirano, Yukinori

Article 1

Optimization of Light-Inducible Gal4/UAS Gene Expression System in Mammalian Cells

iScience, v. 23, (9), 25 September 2020, article number 101506
Yamada, Mayumi; Nagasaki, Shinji C.; Suzuki, Yusuke; Hirano, Yukinori; Imayoshi,Itaru

Article 1

The neural circuit linking mushroom body parallel circuits induces memory consolidation in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (32), 6 August 2019, p. 16080-16085
Awata, Hiroko; Takakura, Mai; Kimura, Yoko; Iwata, Ikuko; Masuda, Tomoko; Hirano, Yukinori

Article 1

Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies

Nature Communications, v. 7, 14 November 2016, article number 13471
Hirano, Yukinori; Ihara, Kunio; Masuda, Tomoko; Yamamoto, Takuya; Iwata, Ikuko; Takahashi, Aya; Awata, Hiroko; Nakamura, Naosuke; Takakura, Mai; Suzuki, Yusuke; Horiuchi, Junjiro; Okuno, Hiroyuki; Saitoe, Minoru

Article 1

Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication

PLoS Genetics, v. 11, (8), 11 August 2015, article number e1005283
Goto, Greicy H.; Zencir, Sevil; Hirano, Yukinori; Ogi, Hiroo; Ivessa, Andreas; Sugimoto, Katsunori

Article 2

Glial dysfunction causes age-related memory impairment in Drosophila

Neuron, v. 84, (4), November 2014, p. 753-763
Yamazaki, Daisuke; Horiuchi, Junjiro; Ueno, Kohei; Ueno, Taro; Saeki, Shinjiro; Matsuno, Motomi; Naganos, Shintaro; Miyashita, Tomoyuki; Hirano, Yukinori; Nishikawa, Hiroyuki; Taoka, Masato; Yamauchi, Yoshio; Isobe, Toshiaki; Honda, Yoshiko; Kodama, Tohru; Masuda, Tomoko; Saitoe, Minoru

空腹による脳機能制御

日常生活の脳科学=Brain and Nerve, v. 66, (1), January 2014, p. 41-48
平野恭敬; 齊藤実

Article 3

Fasting launches CRTC to facilitate long-term memory formation in Drosophila

Science, v. 339, (6118), 25 January 2013, p. 443-446
Hirano, Yukinori; Masuda, Tomoko; Naganos, Shintaro; Matsuno, Motomi; Ueno, Kohei; Miyashita, Tomoyuki; Horiuchi, Junjiro; Saitoe, Minoru

Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger

Communicative & Integrative Biology, v. 6, (5), 4 June 2013
Hirano, Yukinori; Saitoe, Minoru

Long-term enhancement of synaptic transmission between antennal lobe and mushroom body in cultured Drosophila brain

Journal of Physiology, v. 591, (1), January 2013, p. 287-302
Ueno, Kohei; Naganos, Shintaro; Hirano, Yukinori; Horiuchi, Junjiro; Saitoe, Minoru

Article 2

Reactive oxygen species are not involved in the onset of age-related memory impairment in Drosophila

Genes, Brain and Behavior, v. 11, (1), February 2012, p. 79-86
Hirano, Yukinori; Kuriyama, Y.; Miyashita, T.; Horiuchi, J.; Saitoe, M.

Subtelomere-binding protein Tbf1 and telomerebinding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast

Molecular Biology of the Cell, v. 23, (2), 15 January 2012, p. 347-359
Fukunaga, Kenzo; Hirano, Yukinori; Sugimoto, Katsunori

Article 2

Rif1 and Rif2 Inhibit Localization of Tel1 to DNA Ends

Molecular Cell, v. 33, (3), 13 February 2009, p. 312-322
Hirano, Yukinori; Fukunaga, Kenzo; Sugimoto, Katsunori

Role of budding yeast Rad18 in repair of HO-induced double-strand breaks

DNA Repair, v. 8, (1), 2009, p. 51-59
Hirano, Yukinori; Reddy, Jayant; Sugimoto, Katsunori

Article 1

Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends

Molecular Biology of the Cell, v. 18, (6), June 2007, p. 2026-2036
Hirano, Yukinori; Sugimoto, Katsunori

Article 1

ATR homolog Mec1 controls association of DNA polymerase ζ-Rev1 complex with regions near a double-strand break

Current Biology, v. 16, (6), 21 March 2006, p. 586-590
Hirano, Yukinori; Sugimoto, Katsunori

Article 1

Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage

Molecular Biology of the Cell, v. 16, (11), November 2005, p. 5227-5235
Nakada, Daisuke; Hirano, Yukinori; Tanaka, Yuya; Sugimoto, Katsunori

Article 1

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

Molecular and Cellular Biology, v. 24, (22), November 2004, p. 10016-10025
Nakada, Daisuke; Hirano, Yukinori; Sugimoto, Katsunori

2016 1

Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies

Nature Communications, v. 7, 14 November 2016, article number 13471
Hirano, Yukinori; Ihara, Kunio; Masuda, Tomoko; Yamamoto, Takuya; Iwata, Ikuko; Takahashi, Aya; Awata, Hiroko; Nakamura, Naosuke; Takakura, Mai; Suzuki, Yusuke; Horiuchi, Junjiro; Okuno, Hiroyuki; Saitoe, Minoru
Article

2015 1

Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication

PLoS Genetics, v. 11, (8), 11 August 2015, article number e1005283
Goto, Greicy H.; Zencir, Sevil; Hirano, Yukinori; Ogi, Hiroo; Ivessa, Andreas; Sugimoto, Katsunori
Article

2014 2

Glial dysfunction causes age-related memory impairment in Drosophila

Neuron, v. 84, (4), November 2014, p. 753-763
Yamazaki, Daisuke; Horiuchi, Junjiro; Ueno, Kohei; Ueno, Taro; Saeki, Shinjiro; Matsuno, Motomi; Naganos, Shintaro; Miyashita, Tomoyuki; Hirano, Yukinori; Nishikawa, Hiroyuki; Taoka, Masato; Yamauchi, Yoshio; Isobe, Toshiaki; Honda, Yoshiko; Kodama, Tohru; Masuda, Tomoko; Saitoe, Minoru
Article

空腹による脳機能制御

日常生活の脳科学=Brain and Nerve, v. 66, (1), January 2014, p. 41-48
平野恭敬; 齊藤実
Article

2013 3

Fasting launches CRTC to facilitate long-term memory formation in Drosophila

Science, v. 339, (6118), 25 January 2013, p. 443-446
Hirano, Yukinori; Masuda, Tomoko; Naganos, Shintaro; Matsuno, Motomi; Ueno, Kohei; Miyashita, Tomoyuki; Horiuchi, Junjiro; Saitoe, Minoru
Article

Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger

Communicative & Integrative Biology, v. 6, (5), 4 June 2013
Hirano, Yukinori; Saitoe, Minoru
Article

Long-term enhancement of synaptic transmission between antennal lobe and mushroom body in cultured Drosophila brain

Journal of Physiology, v. 591, (1), January 2013, p. 287-302
Ueno, Kohei; Naganos, Shintaro; Hirano, Yukinori; Horiuchi, Junjiro; Saitoe, Minoru
Article

2012 2

Reactive oxygen species are not involved in the onset of age-related memory impairment in Drosophila

Genes, Brain and Behavior, v. 11, (1), February 2012, p. 79-86
Hirano, Yukinori; Kuriyama, Y.; Miyashita, T.; Horiuchi, J.; Saitoe, M.
Article

Subtelomere-binding protein Tbf1 and telomerebinding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast

Molecular Biology of the Cell, v. 23, (2), 15 January 2012, p. 347-359
Fukunaga, Kenzo; Hirano, Yukinori; Sugimoto, Katsunori
Article

2009 2

Rif1 and Rif2 Inhibit Localization of Tel1 to DNA Ends

Molecular Cell, v. 33, (3), 13 February 2009, p. 312-322
Hirano, Yukinori; Fukunaga, Kenzo; Sugimoto, Katsunori
Article

Role of budding yeast Rad18 in repair of HO-induced double-strand breaks

DNA Repair, v. 8, (1), 2009, p. 51-59
Hirano, Yukinori; Reddy, Jayant; Sugimoto, Katsunori
Article

2007 1

Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends

Molecular Biology of the Cell, v. 18, (6), June 2007, p. 2026-2036
Hirano, Yukinori; Sugimoto, Katsunori
Article

2006 1

ATR homolog Mec1 controls association of DNA polymerase ζ-Rev1 complex with regions near a double-strand break

Current Biology, v. 16, (6), 21 March 2006, p. 586-590
Hirano, Yukinori; Sugimoto, Katsunori
Article

2005 1

Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage

Molecular Biology of the Cell, v. 16, (11), November 2005, p. 5227-5235
Nakada, Daisuke; Hirano, Yukinori; Tanaka, Yuya; Sugimoto, Katsunori
Article

2004 1

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

Molecular and Cellular Biology, v. 24, (22), November 2004, p. 10016-10025
Nakada, Daisuke; Hirano, Yukinori; Sugimoto, Katsunori
Article

Teaching Assignment

2024-25 Fall 4 2023-24 Summer 1 2023-24 Spring 5 2023-24 Winter 0 2023-24 Fall 8 2022-23 Summer 1

LIFS2070	Introduction to Biotechnology
LIFS4550	Biochemistry of Nutrition
LIFS5710	Cellular Regulation
LIFS6114H	Current Topics in Biotechnology and Traditional Chinese Medicine

BTEC5210

Principles and Application in Biotechnology

LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4963	Biotechnology Capstone Project
LIFS4981	Biochemistry and Cell Biology Project Research II
LIFS6660	Molecular Medicine
SCIE3900	International Research Experience

LIFS2070	Introduction to Biotechnology
LIFS4550	Biochemistry of Nutrition
LIFS4950	Neurochemistry
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4963	Biotechnology Capstone Project
LIFS4971	Biochemistry and Cell Biology Project Research I
LIFS5710	Cellular Regulation
LIFS6114G	Current Topics in Biotechnology and Traditional Chinese Medicine

BTEC5210

Principles and Application in Biotechnology

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

HU, Xinyue
Life Science
LAM, Yu Hong
Life Science
ALIA, Abdalla Galaa Mohamed
Life Science
GU, Yuzhe
Life Science

Master of Philosophy

FUNG, Yu Shan
Life Science
HO, Lok Yin
Life Science
LI, Weijia
Life Science

Graduated RPGs

Master of Philosophy

HU, Xinyue
Life Science( Completed in 2024 )
LAM, Yu Hong
Life Science( Completed in 2024 )
WANG, Zigao
Life Science( Completed in 2023 )
NG, Man Yung
Life Science( Completed in 2022 )

Projects

From January 2022 to December 2024

All Projects 2

No Projects.
Investigation of the molecular and neural-circuit mechanisms of memory updating through activity-dependent gene expression

通過活性依賴性基因表達研究記憶更新的分子和神經電路機制 Leading

RGC - General Research Fund
Project Team (HKUST)
HIRANO Yukinori (Lead)
2024 -
Investigation of the mechanism of memory clearance through activity-dependent transcription

關於利用活動依賴性轉錄所達成的記憶清除機理的研究 Leading

RGC - General Research Fund
Project Team (HKUST)
HIRANO Yukinori (Lead)
2023 -

Research Interest

Publications

2024 1

2023 3

2022 2

2021 1

2020 1

2019 1

2016 1

2015 1

2014 2

2013 3

2012 2

2009 2

2007 1

2006 1

2005 1

2004 1

Article 1

Article 1

Conference paper 2

Article 2

Article 1

Article 1

Article 1

Article 1

Article 1

Article 2

Article 3

Article 2

Article 2

Article 1

Article 1

Article 1

Article 1

2016 1

2015 1

2014 2

2013 3

2012 2

2009 2

2007 1

2006 1

2005 1

2004 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

Current RPGs

Graduated RPGs

Projects

From January 2022 to December 2024

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