Faculty Profiles - ZHAI Yuanliang | The Hong Kong University of Science and Technology

Yuanliang ZHAI
翟元梁

PhD in Biochemistry
The Hong Kong University of Science and Technology, 2010

Associate Professor
Division of Life Science

(852) 2358 7308
zhai@ust.hk
Room 5446
Personal Web

Google Scholar

6_vkSxQAAAAJ

ORCID

0000-0002-8897-6416

ResearcherID

FXJ-4446-2022

Scopus ID

36614890800

Research Interest Publications Projects

Research Interest

Deoxyribonucleic acid (DNA) replication
Epigenetics
Chromatin structure
Structural biology
Imaging techniques
Electron microscopy

Publications

All Years 30 2025 0 2024 5 2023 4 2022 1 2021 1 2020 1 2019 18

2024 5

Parental histone transfer caught at the replication fork

Nature, v. 627, (8005), March 2024, p. 890-897
Li, Ningning; Gao, Yuan; Zhang, Yujie; Yu, Daqi; Lin, JIanwei; Feng, Jiaxuan; Li, Jian; Xu, Zhichun; Zhang, Yingyi; Dang, Shangyu; Zhou, Keda; Liu, Yang; Li, Xiang David; Tye, Bik Kwoon; Li, Qing; Gao, Ning; Zhai, Yuanliang
Article

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex

Nature Communications, v. 15, (1), September 2024, article number 8039
Wu, Yue; Zhang, Qiongdan; Lin, Yuhan; Lam, Wai Hei; Zhai, Yuanliang
Article

Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA-histone interactions

Nucleic Acids Research, v. 52, (19), October 2024, p. 11612-11625
Ding, Dongbo; Pang, Yu Hin; Deng, Mingxi; Nguyen, Thi Thuy; Liu, Yue; Sun, Xulun; Xu, Zhichun; Zhang, Yingyi; Zhai, Yuanliang; Yan, Yan; Ishibashi, Toyotaka
Article

The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans

Biology, v. 13, (1), January 2024, article number 13
Tye, Bik-Kwoon; Zhai, Yuanliang
Article

Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets

Nature Structural and Molecular Biology, v. 32, (2), February 2025, p. 358-368
Luo, Jingyi; Lam, Wai Hei; Yu, Daqi; Chao, Victor C.; Zopfi, Marc Nicholas; Khoo, Chen Jing; Zhao, Chang; Yan, Shan; Liu, Zheng; Li, Xiang David; Zheng, Chaogu; Zhai, Yuanliang; Ti, Shih-Chieh
Article

2023 4

DDK promotes DNA replication initiation: Mechanistic and structural insights

Current Opinion in Structural Biology, v. 78, February 2023, article number 102504
Li, Ningning; Gao, Ning; Zhai, Yuanliang
Article

Menin “reads” H3K79me2 mark in a nucleosomal context

Science, v. 379, (6633), February 2023, p. 717-723
Lin, Jianwei; Wu, Yiping; Tian, Gaofei; Yu, Daqi; Yang, Eunjeong; Lam, Wai Hei; Liu, Zheng; Jing, Yihang; Dang, Shangyu; Bao, Xiucong; Wong, Jason Wing Hon; Zhai, Yuanliang; Li, Xiang David
Article

Synergism between CMG helicase and leading strand DNA polymerase at replication fork

Nature Communications, v. 14, (1), September 2023, article number 5849
Xu, Zhichun; Feng, Jianrong; Yu, Daqi; Huo, Yunjing; Ma, Xiaohui; Lam, Wai Hei; Liu, Zheng; Li, Xiang David; Ishibashi, Toyotaka; Dang, Shangyu; Zhai, Yuanliang
Article

The human pre-replication complex is an open complex

Cell, v. 186, (1), January 2023, p. 98-111
Li, Jian; Dong, Jiangqing; Wang, Weitao; Yu, Daqi; Fan, Xinyu; Hui, Yan Chit; Lee, Clare S.K.; Lam, Wai Hei; Alary, Nathan; Yang, Yang; Zhang, Yingyi; Zhao, Qian; Chen, Chun-Long; Tye yeung, Bik Kwoon; Dang, Shangyu; Zhai, Yuanliang
Article

2022 1

Structural Insight into the MCM Double Hexamer Activation by Dbf4-Cdc7 Kinase

Nature Communications, v. 13, (1), March 2022, article number 1396
Cheng, Jiaxuan; Li, Ningning; Huo, Yunjing; Dang, Shangyu; Tye, Bik Kwoon; Gao, Ning; Zhai, Yuanliang
Article

2021 1

Humanizing the yeast origin recognition complex

Nature Communications, v. 12, (1), January 2021, article number 33
Lee, Clara S.K.; Cheung, Ming Fung; Li, Jinsen; Zhao, Yongqian; Lam, Wai Hei; Ho, Vincy Wing Sze; Rohs, Remo; Zhai, Yuanliang; Leung, Danny; Tye, Bik Kwoon
Article

2020 1

Structural insight into the assembly and conformational activation of human origin recognition complex

Cell Discovery, v. 6, (1), November 2020, article number 88
Cheng, Jiaxuan; Li, Ningning; Wang, Xiaohan; Hu, Jiazhi; Zhai, Yuanliang; Gao, Ning
Article

2018 2

Structure of the Origin Recognition Complex Bound to DNA Replication Origin

Nature, v. 559, (7713), July 2018, p. 217-222
Li, Ningning; Lam, Wai Hei; Zhai, Yuanliang; Cheng, Jiaxuan; Cheng, Erchao; Zhao, Yongqian; Gao, Ning; Tye Yeung, Bik Kwoon
Article

Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex

DNA Replication: From Old Principles to New Discoveries / edited by Hisao Masai, Marco Foiani. Singapore : Springer, 2018, p. 189-205, Book series: Advances in Experimental Medicine and Biology book, v. 1042
Zhai, Yuanliang; Tye, Bik Kwoon YEUNG
Book chapter

2017 2

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

Nature Structural and Molecular Biology, v. 24, (3), March 2017, p. 300-308
Zhai, Yuanliang; Cheng, Erchao; Wu, Hao; Li, Ningning; Yung, Philip Yuk Kwong; Gao, Ning; Tye, Bik Kwoon
Article

Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing

Molecular Cell, v. 67, (2), July 2017, p. 168-179
Zhai, Yuanliang; Li, Ningning; Jiang, Hanlun; Huang, Xuhui; Gao, Ning; Tye, Bik Kwoon
Article

2016 1

A Robust Two-Color Super-Resolution Localization Microscope

Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng
Conference paper

2015 2

A user-friendly two-color super-resolution localization microscope

Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak
Article

Structure of the eukaryotic MCM complex at 3.8 Å

Nature, v. 524, (7564), August 2015, p. 186-191
Li, Ningning; Zhai, Yuanliang; Zhang, Yixiao; Li, Wanqiu; Yang, Maojun; Lei, Jianlin; Tye, Bik-Kwoon; Gao, Ning
Article

2012 1

The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis

Cell Cycle, v. 11, (7), April 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun
Article

2011 1

Cell Cycle Control of DNA Replication by Phosphorylation and Dephosphorylation of Replication-Initiation Proteins in Budding Yeast

Fundamental Aspects of DNA Replication / edited by Jelena Kušić-Tišma. IntechOpen, 2011, p. 87-106, ch. 6
Zhai, Yuanliang; Yung, Philip Yuk Kwong; Liang, Chun
Book chapter

2010 5

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast

Journal of Biological Chemistry, v. 285, (39), September 2010, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun
Article

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Journal of cell science, v. 123, (22), November 2010, p. 3933-3943
Zhai, Yuanliang; Yung, Philip Y. K.; Huo, Lin; Liang, Chun
Article

Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae

Cell Cycle, v. 9, (21), November 2010, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, Tsz-choi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun
Article

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun
Conference paper

Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast

Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun
Conference paper

2008 2

The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis

The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun
Conference paper

The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis

11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun
Conference paper

2005 2

DNA Replication-initiation Proteins as Novel Anticancer Targets

Croucher Advanced Study Institute on 'Molecular Genetics & Cell Signaling in Cancers', The University of Hong Kong, Jan. 2005
Feng, Daorong; Tu, Zheng; Yu, Zhiling; Lu, Yongjun; Chan, Tszchoi; Zhai, Yuanliang; Zou, Lan; Hu, Yun; Wu, Xing; Zhong, Shan; Zhang, Wei; Xu, Anlong; Liang, Chun
Conference paper

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun
Conference paper

Article 5

Parental histone transfer caught at the replication fork

Nature, v. 627, (8005), March 2024, p. 890-897
Li, Ningning; Gao, Yuan; Zhang, Yujie; Yu, Daqi; Lin, JIanwei; Feng, Jiaxuan; Li, Jian; Xu, Zhichun; Zhang, Yingyi; Dang, Shangyu; Zhou, Keda; Liu, Yang; Li, Xiang David; Tye, Bik Kwoon; Li, Qing; Gao, Ning; Zhai, Yuanliang

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex

Nature Communications, v. 15, (1), September 2024, article number 8039
Wu, Yue; Zhang, Qiongdan; Lin, Yuhan; Lam, Wai Hei; Zhai, Yuanliang

Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA-histone interactions

Nucleic Acids Research, v. 52, (19), October 2024, p. 11612-11625
Ding, Dongbo; Pang, Yu Hin; Deng, Mingxi; Nguyen, Thi Thuy; Liu, Yue; Sun, Xulun; Xu, Zhichun; Zhang, Yingyi; Zhai, Yuanliang; Yan, Yan; Ishibashi, Toyotaka

The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans

Biology, v. 13, (1), January 2024, article number 13
Tye, Bik-Kwoon; Zhai, Yuanliang

Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets

Nature Structural and Molecular Biology, v. 32, (2), February 2025, p. 358-368
Luo, Jingyi; Lam, Wai Hei; Yu, Daqi; Chao, Victor C.; Zopfi, Marc Nicholas; Khoo, Chen Jing; Zhao, Chang; Yan, Shan; Liu, Zheng; Li, Xiang David; Zheng, Chaogu; Zhai, Yuanliang; Ti, Shih-Chieh

Article 4

DDK promotes DNA replication initiation: Mechanistic and structural insights

Current Opinion in Structural Biology, v. 78, February 2023, article number 102504
Li, Ningning; Gao, Ning; Zhai, Yuanliang

Menin “reads” H3K79me2 mark in a nucleosomal context

Science, v. 379, (6633), February 2023, p. 717-723
Lin, Jianwei; Wu, Yiping; Tian, Gaofei; Yu, Daqi; Yang, Eunjeong; Lam, Wai Hei; Liu, Zheng; Jing, Yihang; Dang, Shangyu; Bao, Xiucong; Wong, Jason Wing Hon; Zhai, Yuanliang; Li, Xiang David

Synergism between CMG helicase and leading strand DNA polymerase at replication fork

Nature Communications, v. 14, (1), September 2023, article number 5849
Xu, Zhichun; Feng, Jianrong; Yu, Daqi; Huo, Yunjing; Ma, Xiaohui; Lam, Wai Hei; Liu, Zheng; Li, Xiang David; Ishibashi, Toyotaka; Dang, Shangyu; Zhai, Yuanliang

The human pre-replication complex is an open complex

Cell, v. 186, (1), January 2023, p. 98-111
Li, Jian; Dong, Jiangqing; Wang, Weitao; Yu, Daqi; Fan, Xinyu; Hui, Yan Chit; Lee, Clare S.K.; Lam, Wai Hei; Alary, Nathan; Yang, Yang; Zhang, Yingyi; Zhao, Qian; Chen, Chun-Long; Tye yeung, Bik Kwoon; Dang, Shangyu; Zhai, Yuanliang

Article 1

Structural Insight into the MCM Double Hexamer Activation by Dbf4-Cdc7 Kinase

Nature Communications, v. 13, (1), March 2022, article number 1396
Cheng, Jiaxuan; Li, Ningning; Huo, Yunjing; Dang, Shangyu; Tye, Bik Kwoon; Gao, Ning; Zhai, Yuanliang

Article 1

Humanizing the yeast origin recognition complex

Nature Communications, v. 12, (1), January 2021, article number 33
Lee, Clara S.K.; Cheung, Ming Fung; Li, Jinsen; Zhao, Yongqian; Lam, Wai Hei; Ho, Vincy Wing Sze; Rohs, Remo; Zhai, Yuanliang; Leung, Danny; Tye, Bik Kwoon

Article 1

Structural insight into the assembly and conformational activation of human origin recognition complex

Cell Discovery, v. 6, (1), November 2020, article number 88
Cheng, Jiaxuan; Li, Ningning; Wang, Xiaohan; Hu, Jiazhi; Zhai, Yuanliang; Gao, Ning

Article 1

Structure of the Origin Recognition Complex Bound to DNA Replication Origin

Nature, v. 559, (7713), July 2018, p. 217-222
Li, Ningning; Lam, Wai Hei; Zhai, Yuanliang; Cheng, Jiaxuan; Cheng, Erchao; Zhao, Yongqian; Gao, Ning; Tye Yeung, Bik Kwoon

Book chapter 1

Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex

DNA Replication: From Old Principles to New Discoveries / edited by Hisao Masai, Marco Foiani. Singapore : Springer, 2018, p. 189-205, Book series: Advances in Experimental Medicine and Biology book, v. 1042
Zhai, Yuanliang; Tye, Bik Kwoon YEUNG

Article 2

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

Nature Structural and Molecular Biology, v. 24, (3), March 2017, p. 300-308
Zhai, Yuanliang; Cheng, Erchao; Wu, Hao; Li, Ningning; Yung, Philip Yuk Kwong; Gao, Ning; Tye, Bik Kwoon

Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing

Molecular Cell, v. 67, (2), July 2017, p. 168-179
Zhai, Yuanliang; Li, Ningning; Jiang, Hanlun; Huang, Xuhui; Gao, Ning; Tye, Bik Kwoon

Conference paper 1

A Robust Two-Color Super-Resolution Localization Microscope

Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng

Article 2

A user-friendly two-color super-resolution localization microscope

Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak

Structure of the eukaryotic MCM complex at 3.8 Å

Nature, v. 524, (7564), August 2015, p. 186-191
Li, Ningning; Zhai, Yuanliang; Zhang, Yixiao; Li, Wanqiu; Yang, Maojun; Lei, Jianlin; Tye, Bik-Kwoon; Gao, Ning

Article 1

The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis

Cell Cycle, v. 11, (7), April 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun

Book chapter 1

Cell Cycle Control of DNA Replication by Phosphorylation and Dephosphorylation of Replication-Initiation Proteins in Budding Yeast

Fundamental Aspects of DNA Replication / edited by Jelena Kušić-Tišma. IntechOpen, 2011, p. 87-106, ch. 6
Zhai, Yuanliang; Yung, Philip Yuk Kwong; Liang, Chun

Article 3

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast

Journal of Biological Chemistry, v. 285, (39), September 2010, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Journal of cell science, v. 123, (22), November 2010, p. 3933-3943
Zhai, Yuanliang; Yung, Philip Y. K.; Huo, Lin; Liang, Chun

Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae

Cell Cycle, v. 9, (21), November 2010, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, Tsz-choi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun

Conference paper 2

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun

Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast

Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun

Conference paper 2

The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis

The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun

The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis

11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun

Conference paper 2

DNA Replication-initiation Proteins as Novel Anticancer Targets

Croucher Advanced Study Institute on 'Molecular Genetics & Cell Signaling in Cancers', The University of Hong Kong, Jan. 2005
Feng, Daorong; Tu, Zheng; Yu, Zhiling; Lu, Yongjun; Chan, Tszchoi; Zhai, Yuanliang; Zou, Lan; Hu, Yun; Wu, Xing; Zhong, Shan; Zhang, Wei; Xu, Anlong; Liang, Chun

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun

2018 2

Structure of the Origin Recognition Complex Bound to DNA Replication Origin

Nature, v. 559, (7713), July 2018, p. 217-222
Li, Ningning; Lam, Wai Hei; Zhai, Yuanliang; Cheng, Jiaxuan; Cheng, Erchao; Zhao, Yongqian; Gao, Ning; Tye Yeung, Bik Kwoon
Article

Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex

DNA Replication: From Old Principles to New Discoveries / edited by Hisao Masai, Marco Foiani. Singapore : Springer, 2018, p. 189-205, Book series: Advances in Experimental Medicine and Biology book, v. 1042
Zhai, Yuanliang; Tye, Bik Kwoon YEUNG
Book chapter

2017 2

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

Nature Structural and Molecular Biology, v. 24, (3), March 2017, p. 300-308
Zhai, Yuanliang; Cheng, Erchao; Wu, Hao; Li, Ningning; Yung, Philip Yuk Kwong; Gao, Ning; Tye, Bik Kwoon
Article

Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing

Molecular Cell, v. 67, (2), July 2017, p. 168-179
Zhai, Yuanliang; Li, Ningning; Jiang, Hanlun; Huang, Xuhui; Gao, Ning; Tye, Bik Kwoon
Article

2016 1

A Robust Two-Color Super-Resolution Localization Microscope

Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng
Conference paper

2015 2

A user-friendly two-color super-resolution localization microscope

Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak
Article

Structure of the eukaryotic MCM complex at 3.8 Å

Nature, v. 524, (7564), August 2015, p. 186-191
Li, Ningning; Zhai, Yuanliang; Zhang, Yixiao; Li, Wanqiu; Yang, Maojun; Lei, Jianlin; Tye, Bik-Kwoon; Gao, Ning
Article

2012 1

The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis

Cell Cycle, v. 11, (7), April 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun
Article

2011 1

Cell Cycle Control of DNA Replication by Phosphorylation and Dephosphorylation of Replication-Initiation Proteins in Budding Yeast

Fundamental Aspects of DNA Replication / edited by Jelena Kušić-Tišma. IntechOpen, 2011, p. 87-106, ch. 6
Zhai, Yuanliang; Yung, Philip Yuk Kwong; Liang, Chun
Book chapter

2010 5

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast

Journal of Biological Chemistry, v. 285, (39), September 2010, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun
Article

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Journal of cell science, v. 123, (22), November 2010, p. 3933-3943
Zhai, Yuanliang; Yung, Philip Y. K.; Huo, Lin; Liang, Chun
Article

Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae

Cell Cycle, v. 9, (21), November 2010, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, Tsz-choi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun
Article

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun
Conference paper

Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast

Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun
Conference paper

2008 2

The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis

The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun
Conference paper

The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis

11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun
Conference paper

2005 2

DNA Replication-initiation Proteins as Novel Anticancer Targets

Croucher Advanced Study Institute on 'Molecular Genetics & Cell Signaling in Cancers', The University of Hong Kong, Jan. 2005
Feng, Daorong; Tu, Zheng; Yu, Zhiling; Lu, Yongjun; Chan, Tszchoi; Zhai, Yuanliang; Zou, Lan; Hu, Yun; Wu, Xing; Zhong, Shan; Zhang, Wei; Xu, Anlong; Liang, Chun
Conference paper

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun
Conference paper

No Publications

Projects

From January 2023 to December 2025

All Projects 3 Leading Projects 2 Participating Projects 1

Mechanistic Study of the Parental Histone Recycling at Replication Forks

親代組蛋白在複製叉回收的機制研究 Leading

National Natural Science Foundation of China (NSFC) / Research Grants Council (RGC)
Project Team (HKUST)
ZHAI Yuanliang (Lead)
2025 -
Elucidating the mechanism of origin firing in human cells

人源複製起始位點DNA打開的機制研究 Leading

RGC - General Research Fund
Project Team (HKUST)
ZHAI Yuanliang (Lead)
2025 -
From Structural to Genomic Biology: A Multi-scale Approach Tightly Integrating Structural Biology and Novel Genomics Platform to Quantitatively Analyze the Transcription and its Regulation of SARS-CoV-2 Viral RNA Polymerase

從結構生物學到基因組生物學：一種緊密結合結構生物學和新型基因組學平臺定量分析2019冠狀病毒RNA聚合酶轉錄和調控的多尺度方法 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
ZHAI Yuanliang
2025 -

Research Interest

Publications

2024 5

2023 4

2022 1

2021 1

2020 1

2018 2

2017 2

2016 1

2015 2

2012 1

2011 1

2010 5

2008 2

2005 2

Article 5

Article 4

Article 1

Article 1

Article 1

Article 1

Book chapter 1

Article 2

Conference paper 1

Article 2

Article 1

Book chapter 1

Article 3

Conference paper 2

Conference paper 2

Conference paper 2

2018 2

2017 2

2016 1

2015 2

2012 1

2011 1

2010 5

2008 2

2005 2

Projects

From January 2023 to December 2025

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