Amide C–N bonds activation by A new variant of bifunctional N-heterocyclic carbene

Biocompatible aggregation-induced emission active polyphosphate-manganese nanosheets with glutamine synthetase-like activity in excitotoxic nerve cells

Discovery and synthesis of atropisomerically chiral acyl-substituted stable vinyl sulfoxonium ylides

Enantioselective Relay Coupling of Perfluoroalkyl and Vinylogous Ketyl Radicals

N-Heterocyclic Carbene-Catalyzed Asymmetric S_N2 Alkylation via Noncovalent Activation

Photochemical three-component assembly of tri-substituted oxazoles through a carbenic phosphorus-nitrile hybrid ylide formation/trapping cascade

Water mediated redox-neutral cleavage of arylalkenes via photoredox catalysis

A Carbene Relay Strategy for Cascade Insertion Reactions

Enantioselective S_N2 Alkylation of Homoenolates by N-Heterocyclic Carbene Catalysis

Hierarchical graph learning for protein–protein interaction

Incorporating Domain Knowledge and Structure-Based Descriptors for Machine Learning: A Case Study of Pd-Catalyzed Sonogashira Reactions

Photoredox Cleavage of a C_sp3-C_sp3 Bond in Aromatic Hydrocarbons

Recent Advances in Ynenamine Chemistry

A Thioether-Catalyzed Cross-Coupling Reaction of Allyl Halides and Arylboronic Acids

An NHC-catalyzed [3+2] cyclization of β-disubstituted enals with benzoyl cyanides

Catalytic cleavage and functionalization of bulky and inert C_sp3–C_sp3 bonds via a relayed proton-coupled electron transfer strategy

Enantioselective Seleno-Michael Addition Reactions Catalyzed by a Chiral Bifunctional N-Heterocyclic Carbene with Noncovalent Activation

Enantioselective synthesis of acyclic monohydrosilanes by steric hindrance assisted C-H silylation

Synthesis of I^(III)/S^(VI) reagents and their reactivity in photochemical cycloaddition reactions with unsaturated bonds

A Bifunctional N-Heterocyclic Carbene as a Noncovalent Organocatalyst for Enantioselective Aza-Michael Addition Reactions

N-Heterocyclic Carbene-Catalyzed 1,4-Alkylacylation of 1,3-Enynes

N-Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective C_radical-C_radical Relay Coupling Involving the Homoenolate Intermediate

Synthesis of α-chiral phosphine sulfides via non-covalent organocatalysis

Direct Synthesis of Bicyclic Acetalsvia Visible Light Catalysis

Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate

Ligand-Controlled C−O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights

Molecular Insights into Small‐Molecule Drug Discovery for SARS‐CoV‐2

Photo-induced energy transfer relay of N-heterocyclic carbene catalysis: An asymmetric α-fluorination/isomerization cascade

Alcohol-Directed ortho -C-H Alkenylation

Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes via Double C-H Activation

Enantio- and Diastereoselective Hydrofluorination of Enals by N-Heterocyclic Carbene Catalysis

N-heterocyclic Carbenes as Bronsted Base Catalysts

Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl₃ and N-Heterocyclic Carbenes

Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis

Enantioselective Cooperative Proton-transfer Catalysis Using Chiral Ammonium Phosphates

Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species

Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- And β-C-H bonds through an Allyl-Iridium Intermediate

Lewis酸对氮杂环卡宾协同催化体系中反应途径的调控

One-pot Ligation Strategy for Atypical Ubiquitin Chains Synthesis by Using the Trifluoroacetamidomethyl-protected Isopeptide-linked Ub (Tfacm-isoUb) Unit

Semi-synthesis of Disulfide-linked Branched Tri-ubiquitin Mimics

Streamlined Asymmetric α-difunctionalization of Ynones

Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift

Amine-Triggered 6π-Electrocyclization–Aromatization Cascade of Ynedienamines

Chemical Synthesis of Histone H2A with Methylation at Gln104

Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation

Comparative Pharmacokinetic Profile of Cyclosporine (CsA) With A Decapeptide and A Linear Analogue

Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation

Enantioselective β-Protonation of Enals via a Shuttling Strategy

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters

Visible-Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives

A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics

Advances in the Development of Catalytic Tethering Directing Groups for C-H Functionalization Reactions

Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst

Diverting C−H Annulation Pathways: Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides

Ligand-Assisted Palladium(II)/(IV) Oxidation for sp ³ CH Fluorination

New Frontiers of N-heterocyclic Carbene Catalysis

A Copper-catalyzed Aerobic Domino Process for the Synthesis of Isoindolin-1-ylidene Derivatives

Asymmetric Intramolecular α-cyclopropanation of Aldehydes Using A Donor/acceptor Carbene Mimetic

Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Rhodium Lewis Acid

Direct Fluorination of Styrenes

Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins

Highly Enantioselective Sulfa-Michael Addition Reactions Using N-heterocyclic Carbene as A Non-covalent Organocatalyst

Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions

Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions

A General Synthesis of Ynones From Aldehydes via Oxidative C-C Bond Cleavage Under Aerobic Conditions

A Multitasking Functional Group Leads to Structural Diversity Using Designer C-H Activation Reaction Cascades

Asymmetric Catalysis With N-heterocyclic Carbenes as Non-covalent Chiral Templates

Directed Arene/alkyne Annulation Reactions via Aerobic Copper Catalysis

Highly Ortho-selective Trifluoromethyl-thiolation Reactions Using A Ligand Exchange Strategy

Metal-templated Chiral Brønsted Base Organocatalysis

New Semi-synthesis of Ubiquitin C-terminal Conjugate With 7-amino-4-methylcoumarin

Palladium Catalyzed Acetoxylation of Benzylic C-H Bonds Using a Bidentate Picolinamide Directing Group

Ruthenium-catalyzed Redox-neutral C-H Activation via N-N Cleavage: Synthesis of N-substituted Indoles

Selective Synthesis of Indazoles and Indoles via Triazene-alkyne Cyclization Switched by Different Metals

Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-directed C-H Annulation Cascade

A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines: Quaternary Stereogenic Center Inversion and Functionalization

A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade

Computational Study on Mechanism of Rh(III)-catalyzed Oxidative Heck Coupling of Phenol Carbamates With Alkenes

Direct α-vinylidenation of Aldehydes and Subsequent Cascade: Gold and Amine Catalysts Work Synergistically

Enantioselective Synthesis of 1,2,4-triazolines Catalyzed by A Cinchona Alkaloid-derived Organocatalyst

Expanding Structural Diversity; Removable and Manipulable Directing Groups for C-H Activation

General and Efficient Synthesis of Indoles Through Triazene-directed C-H Annulation

Highly Practical Synthesis of Nitriles and Heterocycles From Alcohols Under Mild Conditions by Aerobic Double Dehydrogenative Catalysis

Highly Trans- Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-catalyzed Triple Cascade Catalysis

Mechanism-based Design of a Photoactivatable Firefly Luciferase

Synthesis of α,β-unsaturated Carbonyl Compounds via a Visible-light-promoted Organocatalytic Aerobic Oxidation

Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation

An Air-State Fe₃S₄ Complex with Properties Similar to Those of The H_OXair State of The Diiron Hydrogenases

General Palladium-catalyzed Aerobic Dehydrogenation to Generate Double Bonds

One-pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using A Cascade Strategy

Rhodium(III)-catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group

Design of Potent and Selective GPR119 Agonists for Type II Diabetes

A Thiourea-Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefin

Expedient, High-yielding Synthesis of Silyl-substituted Salen Ligands

Enantioselective Organo-cascade Catalysis

Single Enantiomers From a Chiral-alcohol Catalyst

An Efficient Approach to Aspidosperma Alkaloids via [4 + 2] Cycloadditions of Aminosiloxydienes: Stereocontrolled Total Synthesis of (±)-tabersonine. Gram-scale Catalytic Asymmetric Syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric Syntheses of (+)-aspidospermidine and (-)-quebrachamine

Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes

Design and Development of Highly Effective Lewis Acid Catalysts for Enantioselective Diels-alder Reactions

Hydrogen-bond-promoted Hetero-diels-alder Reactions of Unactivated Ketones

The First Catalytic Enantioselective Diels-alder Reactions of 1,2-dihydropyridine: Efficient Syntheses of Optically Active 2-azabicyclo[2.2.2]octanes With Chiral Binam Derived Cr(III) Salen Complexes

Hetero Diels-alder Reactions of 1-amino-3-siloxy-1,3-butadienes Under Strictly Thermal Conditions

Highly Enantioselective Diels-Alder Reactions of 1-Amino-3-siloxy-dienes Catalyzed by Cr(III)-Salen Complexes

Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl₃ and N-Heterocyclic Carbenes

Article

Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis

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Enantioselective Cooperative Proton-transfer Catalysis Using Chiral Ammonium Phosphates

Article

Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species

Article

Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- And β-C-H bonds through an Allyl-Iridium Intermediate

Article

Lewis酸对氮杂环卡宾协同催化体系中反应途径的调控

Article

One-pot Ligation Strategy for Atypical Ubiquitin Chains Synthesis by Using the Trifluoroacetamidomethyl-protected Isopeptide-linked Ub (Tfacm-isoUb) Unit

Article

Semi-synthesis of Disulfide-linked Branched Tri-ubiquitin Mimics

Article

Streamlined Asymmetric α-difunctionalization of Ynones

Article

Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

Article

Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift

Article

Amine-Triggered 6π-Electrocyclization–Aromatization Cascade of Ynedienamines

Article

Chemical Synthesis of Histone H2A with Methylation at Gln104

Article

Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation

Article

Comparative Pharmacokinetic Profile of Cyclosporine (CsA) With A Decapeptide and A Linear Analogue

Article

Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation

Article

Enantioselective β-Protonation of Enals via a Shuttling Strategy

Article

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

Article

Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters

Article

Visible-Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives

Article

A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics

Article

Advances in the Development of Catalytic Tethering Directing Groups for C-H Functionalization Reactions

Article

Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst

Article

Diverting C−H Annulation Pathways: Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides

Article

Ligand-Assisted Palladium(II)/(IV) Oxidation for sp ³ CH Fluorination

Article

New Frontiers of N-heterocyclic Carbene Catalysis

Article

A Copper-catalyzed Aerobic Domino Process for the Synthesis of Isoindolin-1-ylidene Derivatives

Article

Asymmetric Intramolecular α-cyclopropanation of Aldehydes Using A Donor/acceptor Carbene Mimetic

Article

Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Rhodium Lewis Acid

Article

Direct Fluorination of Styrenes

Article

Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins

Article

Highly Enantioselective Sulfa-Michael Addition Reactions Using N-heterocyclic Carbene as A Non-covalent Organocatalyst

Article

Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions

Article

Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions

Article

A General Synthesis of Ynones From Aldehydes via Oxidative C-C Bond Cleavage Under Aerobic Conditions

Article

A Multitasking Functional Group Leads to Structural Diversity Using Designer C-H Activation Reaction Cascades

Article

Asymmetric Catalysis With N-heterocyclic Carbenes as Non-covalent Chiral Templates

Article

Directed Arene/alkyne Annulation Reactions via Aerobic Copper Catalysis

Article

Highly Ortho-selective Trifluoromethyl-thiolation Reactions Using A Ligand Exchange Strategy

Article

Metal-templated Chiral Brønsted Base Organocatalysis

Article

New Semi-synthesis of Ubiquitin C-terminal Conjugate With 7-amino-4-methylcoumarin

Article

Palladium Catalyzed Acetoxylation of Benzylic C-H Bonds Using a Bidentate Picolinamide Directing Group

Article

Ruthenium-catalyzed Redox-neutral C-H Activation via N-N Cleavage: Synthesis of N-substituted Indoles

Article

Selective Synthesis of Indazoles and Indoles via Triazene-alkyne Cyclization Switched by Different Metals

Article

Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-directed C-H Annulation Cascade

Article

A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines: Quaternary Stereogenic Center Inversion and Functionalization

Article

A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade

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Computational Study on Mechanism of Rh(III)-catalyzed Oxidative Heck Coupling of Phenol Carbamates With Alkenes

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Direct α-vinylidenation of Aldehydes and Subsequent Cascade: Gold and Amine Catalysts Work Synergistically

Article

Enantioselective Synthesis of 1,2,4-triazolines Catalyzed by A Cinchona Alkaloid-derived Organocatalyst

Article

Expanding Structural Diversity; Removable and Manipulable Directing Groups for C-H Activation

Article

General and Efficient Synthesis of Indoles Through Triazene-directed C-H Annulation

Article

Highly Practical Synthesis of Nitriles and Heterocycles From Alcohols Under Mild Conditions by Aerobic Double Dehydrogenative Catalysis

Article

Highly Trans- Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-catalyzed Triple Cascade Catalysis

Article

Mechanism-based Design of a Photoactivatable Firefly Luciferase

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Synthesis of α,β-unsaturated Carbonyl Compounds via a Visible-light-promoted Organocatalytic Aerobic Oxidation

Article

Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation

Article

An Air-State Fe₃S₄ Complex with Properties Similar to Those of The H_OXair State of The Diiron Hydrogenases

Article

General Palladium-catalyzed Aerobic Dehydrogenation to Generate Double Bonds

Article

One-pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using A Cascade Strategy

Article

Rhodium(III)-catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group

Article

Design of Potent and Selective GPR119 Agonists for Type II Diabetes

Article

A Thiourea-Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefin

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Expedient, High-yielding Synthesis of Silyl-substituted Salen Ligands

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Enantioselective Organo-cascade Catalysis

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Single Enantiomers From a Chiral-alcohol Catalyst

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An Efficient Approach to Aspidosperma Alkaloids via [4 + 2] Cycloadditions of Aminosiloxydienes: Stereocontrolled Total Synthesis of (±)-tabersonine. Gram-scale Catalytic Asymmetric Syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric Syntheses of (+)-aspidospermidine and (-)-quebrachamine

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Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes

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Design and Development of Highly Effective Lewis Acid Catalysts for Enantioselective Diels-alder Reactions

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Hydrogen-bond-promoted Hetero-diels-alder Reactions of Unactivated Ketones

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The First Catalytic Enantioselective Diels-alder Reactions of 1,2-dihydropyridine: Efficient Syntheses of Optically Active 2-azabicyclo[2.2.2]octanes With Chiral Binam Derived Cr(III) Salen Complexes

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Hetero Diels-alder Reactions of 1-amino-3-siloxy-1,3-butadienes Under Strictly Thermal Conditions

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Highly Enantioselective Diels-Alder Reactions of 1-Amino-3-siloxy-dienes Catalyzed by Cr(III)-Salen Complexes

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