Deep lead optimization enveloped in protein pocket and its application in designing potent and selective ligands targeting LTK protein

Elucidating Binding Selectivity in Cyclin-Dependent Kinases 4, 6, and 9: Development of Highly Potent and Selective CDK4/9 Inhibitors

Enantioselective intramolecular cyclopropanation via a cationic sulfoxonium-Rh-carbene

Extreme potential photocatalysis enabled by spin-exchange Auger processes in magnetic-doped quantum dots

Molecule generation for target protein binding with hierarchical consistency diffusion model

NHC-Free Ketone Synthesis via Radical Coupling Mechanisms

Organocatalytic Atroposelective Synthesis of Axially Chiral Indolyl Ketosulfoxonium Ylides

Publisher Correction: Redox-neutral photocatalytic hydrodealkenylation of aryl olefins (Nature Communications, (2025), 16, 1, (5553), 10.1038/s41467-025-60229-y)

Redox-neutral photocatalytic hydrodealkenylation of aryl olefins

Stereoselective diversification of α-amino acids enabled by N-heterocyclic carbene catalysis

Amide C–N bonds activation by A new variant of bifunctional N-heterocyclic carbene

Biocompatible aggregation-induced emission active polyphosphate-manganese nanosheets with glutamine synthetase-like activity in excitotoxic nerve cells

Discovery and synthesis of atropisomerically chiral acyl-substituted stable vinyl sulfoxonium ylides

Enantioselective Relay Coupling of Perfluoroalkyl and Vinylogous Ketyl Radicals

MolNexTR: a generalized deep learning model for molecular image recognition

N-Heterocyclic Carbene-Catalyzed Asymmetric S_N2 Alkylation via Noncovalent Activation

Photochemical three-component assembly of tri-substituted oxazoles through a carbenic phosphorus-nitrile hybrid ylide formation/trapping cascade

Water mediated redox-neutral cleavage of arylalkenes via photoredox catalysis

A Carbene Relay Strategy for Cascade Insertion Reactions

Enantioselective S_N2 Alkylation of Homoenolates by N-Heterocyclic Carbene Catalysis

Incorporating Domain Knowledge and Structure-Based Descriptors for Machine Learning: A Case Study of Pd-Catalyzed Sonogashira Reactions

Photoredox Cleavage of a C_sp3-C_sp3 Bond in Aromatic Hydrocarbons

Recent Advances in Ynenamine Chemistry

A Cross-Coupling Reaction Between Aliphatic Aldehydes And Sulfonium Salts

A Thioether-Catalyzed Cross-Coupling Reaction of Allyl Halides and Arylboronic Acids

Addition of Alcohols onto Electron-Deficient Heteroarenium Salts: A Reversible Covalent Bonding Process under Basic Conditions

An NHC-catalyzed [3+2] cyclization of β-disubstituted enals with benzoyl cyanides

Catalytic cleavage and functionalization of bulky and inert C_sp3–C_sp3 bonds via a relayed proton-coupled electron transfer strategy

Enantioselective Seleno-Michael Addition Reactions Catalyzed by a Chiral Bifunctional N-Heterocyclic Carbene with Noncovalent Activation

Enantioselective synthesis of acyclic monohydrosilanes by steric hindrance assisted C-H silylation

Synthesis of I^(III)/S^(VI) reagents and their reactivity in photochemical cycloaddition reactions with unsaturated bonds

A Bifunctional N-Heterocyclic Carbene as a Noncovalent Organocatalyst for Enantioselective Aza-Michael Addition Reactions

Molecular Insights into Small-Molecule Drug Discovery for SARS-CoV-2

N-Heterocyclic Carbene-Catalyzed 1,4-Alkylacylation of 1,3-Enynes

N-Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective C_radical-C_radicalRelay Coupling Involving the Homoenolate Intermediate

Photo-induced energy transfer relay of N-heterocyclic carbene catalysis: an asymmetric α-fluorination/isomerization cascade

Synthesis of α-chiral phosphine sulfides via non-covalent organocatalysis

Direct Synthesis of Bicyclic Acetals via Visible Light Catalysis

Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate

Ligand-Controlled C−O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights

Alcohol-Directed ortho -C-H Alkenylation

Dehydrogenative annulation of γ,δ-unsaturated amides and alkynes via double C-H activation

Enantio- and Diastereoselective Hydrofluorination of Enals by N-Heterocyclic Carbene Catalysis

N-heterocyclic carbenes as brønsted base catalysts

N-heterocyclic Carbenes as Bronsted Base Catalysts

Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl₃ and N-Heterocyclic Carbenes

Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis

Enantioselective cooperative proton-transfer catalysis using chiral ammonium phosphates

Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species

Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- And β-C-H bonds through an Allyl-Iridium Intermediate

Lewis酸对氮杂环卡宾协同催化体系中反应途径的调控

One-pot ligation strategy for atypical ubiquitin chains synthesis by using the trifluoroacetamidomethyl-protected isopeptide-linked Ub (Tfacm-isoUb) unit

Semi-synthesis of disulfide-linked branched tri-ubiquitin mimics

Streamlined asymmetric α-difunctionalization of ynones

Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift

Amine-Triggered 6π-Electrocyclization–Aromatization Cascade of Ynedienamines

Chemical synthesis of histone H2A with methylation at Gln104

Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I^1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation

Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation

Enantioselective β-Protonation of Enals via a Shuttling Strategy

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters

Visible-Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives

A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics

Advances in the development of catalytic tethering directing groups for C-H functionalization reactions

Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst

Diverting c−H annulation pathways: Nickel-Catalyzed dehydrogenative homologation of aromatic amides

Front Cover Picture: Ligand-Assisted Palladium(II)/(IV) Oxidation for sp³CH Fluorination (Adv. Synth. Catal. 12/2016)

Ligand-Assisted Palladium(II)/(IV) Oxidation for sp³CH Fluorination

New frontiers of N-heterocyclic carbene catalysis

A copper-catalyzed aerobic domino process for the synthesis of isoindolin-1-ylidene derivatives

Asymmetric intramolecular α-cyclopropanation of aldehydes using a donor/acceptor carbene mimetic

Direct fluorination of styrenes

Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins

Highly enantioselective sulfa-Michael addition reactions using N-heterocyclic carbene as a non-covalent organocatalyst

Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions

Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions

A general synthesis of ynones from aldehydes via oxidative C-C bond cleavage under aerobic conditions

A multitasking functional group leads to structural diversity using designer C-H activation reaction cascades

Asymmetric catalysis with N-heterocyclic carbenes as non-covalent chiral templates

Directed arene/alkyne annulation reactions via aerobic copper catalysis

Highly ortho-selective trifluoromethylthiolation reactions using a ligand exchange strategy

New semi-synthesis of ubiquitin C-terminal conjugate with 7-amino-4-methylcoumarin

Palladium catalyzed acetoxylation of benzylic C-H bonds using a bidentate picolinamide directing group

Ruthenium-catalyzed redox-neutral C-H activation via N-N cleavage: Synthesis of N-substituted indoles

Selective synthesis of indazoles and indoles via triazene-alkyne cyclization switched by different metals

Synthesis of indolo[2,1-a]isoquinolines via a triazene-directed C-H annulation cascade

A highly diastereo- and enantioselective synthesis of tetrahydroquinolines: Quaternary stereogenic center inversion and functionalization

A highly diastereoselective and enantioselective synthesis of polysubstituted pyrrolidines via an organocatalytic dynamic kinetic resolution cascade

Computational study on mechanism of Rh(iii)-catalyzed oxidative Heck coupling of phenol carbamates with alkenes

Direct α-vinylidenation of aldehydes and subsequent cascade: Gold and amine catalysts work synergistically

Enantioselective synthesis of 1,2,4-triazolines catalyzed by a cinchona alkaloid-derived organocatalyst

Erratum: Highly trans -stereoselective synthesis of bicyclic isoxazolidines via copper-catalyzed triple cascade catalysis (Journal of Organic Chemistry (2013) 78 (3503) DOI: 10.1021/jo400215e))

Expanding structural diversity; Removable and manipulable directing groups for C-H activation

General and efficient synthesis of indoles through triazene-directed c-h annulation

Highly practical synthesis of nitriles and heterocycles from alcohols under mild conditions by aerobic double dehydrogenative catalysis

Highly trans- stereoselective synthesis of bicyclic isoxazolidines via copper-catalyzed triple cascade catalysis

Mechanism-based design of a photoactivatable firefly luciferase

Synthesis of α,β-unsaturated carbonyl compounds via a visible-light-promoted organocatalytic aerobic oxidation

Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation

General palladium-catalyzed aerobic dehydrogenation to generate double bonds

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

Rhodium(III)-catalyzed C-H activation of arenes using a versatile and removable triazene directing Group

Expedient, high-yielding synthesis of silyl-substituted salen ligands

Enantioselective organo-cascade catalysis

Single enantiomers from a chiral-alcohol catalyst

An efficient approach to Aspidosperma alkaloids via [4 + 2] cycloadditions of aminosiloxydienes: Stereocontrolled total synthesis of (±)-tabersonine. Gram-scale catalytic asymmetric syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric syntheses of (+)-aspidospermidine and (-)-quebrachamine

Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes

Design and development of highly effective Lewis acid catalysts for enantioselective Diels-Alder reactions

Hydrogen-bond-promoted hetero-Diels-Alder reactions of unactivated ketones

The first catalytic enantioselective Diels-Alder reactions of 1,2-dihydropyridine: Efficient syntheses of optically active 2-azabicyclo[2.2.2]octanes with chiral BINAM derived Cr(III) salen complexes

Hetero Diels-Alder reactions of 1-amino-3-siloxy-1,3-butadienes under strictly thermal conditions

Highly enantioselective Diels-Alder reactions of 1-amino-3-siloxy-dienes catalyzed by Cr(III)-salen complexes [17]

Alcohol-Directed ortho -C-H Alkenylation

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Dehydrogenative annulation of γ,δ-unsaturated amides and alkynes via double C-H activation

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Enantio- and Diastereoselective Hydrofluorination of Enals by N-Heterocyclic Carbene Catalysis

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N-heterocyclic carbenes as brønsted base catalysts

Book chapter

N-heterocyclic Carbenes as Bronsted Base Catalysts

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Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl₃ and N-Heterocyclic Carbenes

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Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis

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Enantioselective cooperative proton-transfer catalysis using chiral ammonium phosphates

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Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species

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Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- And β-C-H bonds through an Allyl-Iridium Intermediate

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Lewis酸对氮杂环卡宾协同催化体系中反应途径的调控

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One-pot ligation strategy for atypical ubiquitin chains synthesis by using the trifluoroacetamidomethyl-protected isopeptide-linked Ub (Tfacm-isoUb) unit

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Semi-synthesis of disulfide-linked branched tri-ubiquitin mimics

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Streamlined asymmetric α-difunctionalization of ynones

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Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

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Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift

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Amine-Triggered 6π-Electrocyclization–Aromatization Cascade of Ynedienamines

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Chemical synthesis of histone H2A with methylation at Gln104

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Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I^1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation

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Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

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Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation

Article

Enantioselective β-Protonation of Enals via a Shuttling Strategy

Article

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

Article

Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters

Article

Visible-Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives

Article

A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics

Article

Advances in the development of catalytic tethering directing groups for C-H functionalization reactions

Article

Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst

Article

Diverting c−H annulation pathways: Nickel-Catalyzed dehydrogenative homologation of aromatic amides

Article

Front Cover Picture: Ligand-Assisted Palladium(II)/(IV) Oxidation for sp³CH Fluorination (Adv. Synth. Catal. 12/2016)

Article

Ligand-Assisted Palladium(II)/(IV) Oxidation for sp³CH Fluorination

Article

New frontiers of N-heterocyclic carbene catalysis

Article

A copper-catalyzed aerobic domino process for the synthesis of isoindolin-1-ylidene derivatives

Article

Asymmetric intramolecular α-cyclopropanation of aldehydes using a donor/acceptor carbene mimetic

Article

Direct fluorination of styrenes

Article

Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins

Article

Highly enantioselective sulfa-Michael addition reactions using N-heterocyclic carbene as a non-covalent organocatalyst

Article

Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions

Article

Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions

Article

A general synthesis of ynones from aldehydes via oxidative C-C bond cleavage under aerobic conditions

Article

A multitasking functional group leads to structural diversity using designer C-H activation reaction cascades

Article

Asymmetric catalysis with N-heterocyclic carbenes as non-covalent chiral templates

Article

Directed arene/alkyne annulation reactions via aerobic copper catalysis

Article

Highly ortho-selective trifluoromethylthiolation reactions using a ligand exchange strategy

Article

New semi-synthesis of ubiquitin C-terminal conjugate with 7-amino-4-methylcoumarin

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Palladium catalyzed acetoxylation of benzylic C-H bonds using a bidentate picolinamide directing group

Article

Ruthenium-catalyzed redox-neutral C-H activation via N-N cleavage: Synthesis of N-substituted indoles

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Selective synthesis of indazoles and indoles via triazene-alkyne cyclization switched by different metals

Article

Synthesis of indolo[2,1-a]isoquinolines via a triazene-directed C-H annulation cascade

Article

A highly diastereo- and enantioselective synthesis of tetrahydroquinolines: Quaternary stereogenic center inversion and functionalization

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A highly diastereoselective and enantioselective synthesis of polysubstituted pyrrolidines via an organocatalytic dynamic kinetic resolution cascade

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Computational study on mechanism of Rh(iii)-catalyzed oxidative Heck coupling of phenol carbamates with alkenes

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Direct α-vinylidenation of aldehydes and subsequent cascade: Gold and amine catalysts work synergistically

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Enantioselective synthesis of 1,2,4-triazolines catalyzed by a cinchona alkaloid-derived organocatalyst

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Erratum: Highly trans -stereoselective synthesis of bicyclic isoxazolidines via copper-catalyzed triple cascade catalysis (Journal of Organic Chemistry (2013) 78 (3503) DOI: 10.1021/jo400215e))

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Expanding structural diversity; Removable and manipulable directing groups for C-H activation

Article

General and efficient synthesis of indoles through triazene-directed c-h annulation

Article

Highly practical synthesis of nitriles and heterocycles from alcohols under mild conditions by aerobic double dehydrogenative catalysis

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Highly trans- stereoselective synthesis of bicyclic isoxazolidines via copper-catalyzed triple cascade catalysis

Article

Mechanism-based design of a photoactivatable firefly luciferase

Article

Synthesis of α,β-unsaturated carbonyl compounds via a visible-light-promoted organocatalytic aerobic oxidation

Article

Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation

Article

General palladium-catalyzed aerobic dehydrogenation to generate double bonds

Article

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

Article

Rhodium(III)-catalyzed C-H activation of arenes using a versatile and removable triazene directing Group

Article

Expedient, high-yielding synthesis of silyl-substituted salen ligands

Article

Enantioselective organo-cascade catalysis

Article

Single enantiomers from a chiral-alcohol catalyst

Article

An efficient approach to Aspidosperma alkaloids via [4 + 2] cycloadditions of aminosiloxydienes: Stereocontrolled total synthesis of (±)-tabersonine. Gram-scale catalytic asymmetric syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric syntheses of (+)-aspidospermidine and (-)-quebrachamine

Article

Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes

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Design and development of highly effective Lewis acid catalysts for enantioselective Diels-Alder reactions

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Hydrogen-bond-promoted hetero-Diels-Alder reactions of unactivated ketones

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The first catalytic enantioselective Diels-Alder reactions of 1,2-dihydropyridine: Efficient syntheses of optically active 2-azabicyclo[2.2.2]octanes with chiral BINAM derived Cr(III) salen complexes

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Hetero Diels-Alder reactions of 1-amino-3-siloxy-1,3-butadienes under strictly thermal conditions

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Highly enantioselective Diels-Alder reactions of 1-amino-3-siloxy-dienes catalyzed by Cr(III)-salen complexes [17]

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