Faculty Profiles - ZENG Yi | The Hong Kong University of Science and Technology

Yi ZENG
曾藝

PhD in Molecular Biology and Biochemistry
Simon Fraser University, 2005

Visiting Professor
Division of Life Science

arialzeng@ust.hk

Google Scholar

nAKa1JAAAAAJ

ResearcherID

HKH-0469-2023

Scopus ID

57217986677

Research Interest Publications

Research Interest

Adult stem cells

Publications

All Years 50 2025 0 2024 2 2023 3 2022 10 2021 8 2020 5 2019 22

2024 2

Ca²⁺ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds

Nature Communications, v. 15, (1), July 2024, article number 6131
Li, Yue; Wang, ShiHui; Zhang, YouHua; Liu, ZhaoYuan; Zheng, YunZhe; Zhang, Kun; Chen, ShiYang; Lv, XiaoYing; Huang, MengWen; Pan, XingChao; Zheng, YaJuan; Yuan, MengYa; Ge, GaoXiang; Zeng, Yi Arial; Lin, ChangDong; Chen, JianFeng
Article

Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress

Cell Stem Cell, v. 31, (1), January 2024, p. 89-105.e6
Liu, Chunye; Xu, Yishu; Yang, Guowei; Tao, Yu; Chang, Jiali; Wang, Shihui; Cheung, Hiu Tung; Chen, Jianfeng; Zeng, Yi Arial
Article

2023 3

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity

Advanced Science, v. 10, (12), April 2023, article number 2207152
Sun, Yingkai; Zhang, Juan; Hong, Jie; Zhang, Zhongyun; Lu, Peng; Gao, Aibo; Ni, Mengshan; Zhang, Zhiyin; Yang, Huanjie; Shen, Juan; Lu, Jieli; Xue, Wenzhi; Lv, Qianqian; Bi, Yufang; Zeng, Yi Arial; Gu, Weiqiong; Ning, Guang; Wang, Weiqing; Liu, Ruixin; Wang, Jiqiu
Article

LRP12 is an endogenous transmembrane inactivator of α4 integrins

Cell Reports, v. 42, (6), June 2023, article number 112667
Huang, MengWen; Lu, Ling; Lin, ChangDong; Zheng, YaJuan; Pan, XingChao; Wang, ShiHui; Chen, ShiYang; Zhang, YouHua; Liu, ChunYe; Ge, GaoXiang; Zeng, Yi Arial; Chen, JianFeng
Article

Progress and challenges in stem cell biology

Nature Cell Biology, v. 25, (2), February 2023, p. 203-206
Apostolou, Effie; Blau, Helen; Chien, Kenneth; Lancaster, Madeline A.; Tata, Purushothama Rao; Trompouki, Eirini; Watt, Fiona M.; Zeng, Yi Arial; Zernicka-Goetz, Magdalena
Article

2022 10

Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry

Cell Reports, v. 41, (8), November 2022, article number 111694
Yu, Qing Cissy; Geng, Ajun; Preusch, Christopher B.; Chen, Yujie; Peng, Guangdun; Xu, Yishu; Jia, Yingying; Miao, Yi; Xue, Huaqing; Gao, Dong; Bao, Lan; Pan, Weijun; Chen, Jianfeng; Garcia, K. Christopher; Cheung, Tom H.; Zeng, Yi Arial
Article

Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3

Oncogene, v. 41, (34), August 2022, p. 4091-4103
Liu, Cui; Wang, JunLei; Zheng, YaJuan; Zhu, Yue; Zhou, ZhengHang; Liu, ZhaoYuan; Lin, ChangDong; Wan, YaoYing; Wen, YaTing; Liu, ChunYe; Yuan, MengYa; Zeng, Yi Arial; Yan, ZhanJun; Ge, GaoXiang; Chen, JianFeng
Article

CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression

Cell Reports, v. 40, (11), September 2022, article number 111331
Zhang, Mengna; Zhang, Lingxian; Geng, Ajun; Li, Xiao; Zhou, Yu; Xu, Liming; Zeng, Yi Arial; Li, Jinpeng; Cai, Cheguo
Article

Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

Cell Reports, v. 38, (2), January 2022, article number 110240
Han, Yingying; Villarreal-Ponce, Alvaro; Gutierrez, Guadalupe; Nguyen, Quy; Sun, Peng; Wu, Ting; Sui, Benjamin; Berx, Geert; Brabletz, Thomas; Kessenbrock, Kai; Zeng, Yi Arial; Watanabe, Kazuhide; Dai, Xing
Article

Embryonic vascular establishment requires protein C receptor-expressing endothelial progenitors

Development (Cambridge), v. 149, (12), June 2022, article number dev200419
Yu, Qing Cissy; Bai, Lanyue; Chen, Yingying; Chen, Yujie; Peng, Guangdun; Wang, Daisong; Yang, Guowei; Cui, Guizhong; Jing, Naihe; Zeng, Yi Arial
Article

Functional hepatobiliary organoids recapitulate liver development and reveal essential drivers of hepatobiliary cell fate determination

Life Medicine, v. 1, (3), December 2022, p. 345-358
He, Juan; Cui, Haoyue; Shi, Xiaohan; Jin, Qiqi; Han, Ximeng; Han, Tiantian; Peng, Jiayin; Guo, Shiwei; Zhang, Lei; Zhao, Yun; Zhou, Bin; Chen, Luonan; Chen, Lei; Zeng, Yi Arial; Wang, Hongyang; Jin, Gang; Gao, Dong
Article

Isolation of mouse pancreatic islet Procr⁺ progenitors and long-term expansion of islet organoids in vitro

Nature Protocols, v. 17, (5), May 2022, p. 1359-1384
Wang, Jingqiang; Wang, Daisong; Chen, Xinyi; Yuan, Shubo; Bai, Lanyue; Liu, Chunye; Zeng, Yi Arial
Article

Organoids

Nature Reviews Methods Primers, v. 2, (1), December 2022 , article number 94
Zhao, Zixuan; Chen, Xinyi; Dowbaj, Anna M.; Sljukic, Aleksandra; Bratlie, Kaitlin; Lin, Luda; Fong, Eliza Li Shan; Balachander, Gowri Manohari; Chen, Zhaowei; Soragni, Alice; Huch, Meritxell; Zeng, Yi Arial; Wang, Qun; Yu, Hanry
Article

Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells

Cell Reports, v. 38, (12), March 2022, article number 110548
Liu, Chunye; Lin, Changdong; Wang, Daisong; Wang, Jingqiang; Tao, Yu; Li, Yue; Chen, Xinyi; Bai, Lanyue; Jia, Yingying; Chen, Jianfeng; Zeng, Yi Arial
Article

Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair

eLife, v. 11, March 2022, article number e75449
Wang, Jingqiang; Liu, Chunye; He, Lingli; Xie, Zhiyao; Bai, Lanyue; Yu, Wentao; Wang, Zuoyun; Lu, Yi; Gao, Dong; Fu, Junfen; Zhang, Lei; Zeng, Yi Arial
Article

2021 8

Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model

Nucleic Acids Research, v. 49, (2), January 2021, p. 726-744
Hung, Yu-Han; Huang, Sha; Dame, Michael K; Yu, Qianhui; Yu, Qing C; Zeng, Yi A; Camp, J. Gray; Spence, Jason R; Sethupathy, Praveen
Article

Endothelial Wnts control mammary epithelial patterning via fibroblast signaling

Cell Reports, v. 34, (13), March 2021, article number 108897
Wang, Jingqiang; Song, Wenqian; Yang, Ruikai; Li, Chao; Wu, Ting; Dong, Xiao Bing; Zhou, Bin; Guo, Xizhi; Chen, Jianfeng; Liu, Zhiyong; Yu, Qing Cissy; Li, Wen; Fu, Junfen; Zeng, Yi Arial
Article

Integrin αEβ7⁺ T cells direct intestinal stem cell fate decisions via adhesion signaling

Cell Research, v. 31, (12), December 2021, p. 1291-1307
Chen, Shiyang; Zheng, Yajuan; Ran, Xiaojuan; Du, Hui; Feng, Hua; Yang, Lei; Wen, Yating; Lin, Changdong; Wang, Shihui; Huang, Mengwen; Yan, Zhanjun; Wu, Dianqing; Wang, Hongyan; Ge, Gaoxiang; Zeng, An; Zeng, Yi Arial; Chen, Jianfeng
Article

Lentiviral CRISPR-guided RNA library screening identified Adam17 as an upstream negative regulator of Procr in mammary epithelium

BMC Biotechnology, v. 21, (1), July 2021, article number 42
Wu, Ting; Wang, Yinghua; Xiao, Tianxiong; Ai, Yirui; Li, Jinsong; Zeng, Yi Arial; Yu, Qing Cissy
Article

MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche

Nature, v. 592, (7855), April 2021, p. 606-610
Wu, Ningbo; Zeng, Yi Arial; Su, Bing
Article

Preface to the special topic on tissue stem cell research

Science China Life Sciences, v. 64, (12), December 2021, p. 1995-1997
Li, Jinsong; Zeng, Yi Arial
Article

Recent advances in tissue stem cells

Science China Life Sciences, v. 64, (12), December 2021, p. 1998-2029
Fu, Xin; He, Qiang; Tao, Yu; Wang, Mengdi; Wang, Wei; Wang, Yalong; Yu, Qing Cissy; Zhang, Fang; Zhang, Xiaoyu; Chen, Ye-Guang; Gao, Dong; Hu, Ping; Hui, Lijian; Wang, Xiaoqun; Zeng, Yi Arial
Article

SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling

Protein and Cell, v. 12, (3), March 2021, p. 174-193
Xu, Liang; Li, Peixue; Hao, Xue; Lu, Yi; Liu, Mingxian; Song, Wenqian; Shan, Lin; Yu, Jiao; Ding, Hongyu; Chen, Shishuang; Yang, Ailing; Zeng, Yi Arial; Zhang, Lei; Jiang, Hai
Article

2020 5

A mutation that blocks integrin α₄β₇activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis

BMC Biology, v. 18, (1), June 2020, article number 64
Zhang, Hailong; Zheng, Yajuan; Pan, Youdong; Lin, Changdong; Wang, Shihui; Yan, Zhanjun; Lu, Ling; Ge, Gaoxiang; Li, Jinsong; Zeng, Yi Arial; Chen, Jianfeng
Article

A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling

eLife, v. 9, August 2020, p. 1-20
Geng, Ajun; Wu, Ting; Cai, Cheguo; Song, Wenqian; Wang, Jiqiu; Yu, Qing Cissy; Zeng, Yi Arial
Article

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

Cell Reports, v. 33, (3), October 2020, article number 108284
He, Lingli; Yuan, Liang; Yu, Wentao; Sun, Yang; Jiang, Dan; Wang, Xiaodong; Feng, Xue; Wang, Zuoyun; Xu, Jinjin; Yang, Ruizeng; Zhang, Wenxiang; Feng, Hua; Chen, Hang-zi; Zeng, Yi Arial; Hui, Lijian; Wu, Qiao; Zhang, Yonglong; Zhang, Lei
Article

Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland

Developmental Biology, v. 458, (1), February 2020, p. 43-51
Cai, Cheguo; Geng, Ajun; Wang, Mengran; Yang, Li; Yu, Qing Cissy; Zeng, Yi Arial
Article

Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr⁺ Progenitors

Cell, v. 180, (6), March 2020, p. 1198-1211.e19
Wang, Daisong; Wang, Jingqiang; Bai, Lanyue; Pan, Hong; Feng, Hua; Clevers, Hans; Zeng, Yi Arial
Article

2019 6

Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Nature Communications, v. 10, (1), June 2019, article number 2761
Malinverno, Matteo; Maderna, Claudio; Abu Taha, Abdallah; Corada, Monica; Orsenigo, Fabrizio; Valentino, Mariaelena; Pisati, Federica; Fusco, Carmela; Graziano, Paolo; Giannotta, Monica; Yu, Qing Cissy; Zeng, Yi Arial; Lampugnani, Maria Grazia; Magnusson, Peetra U.; Dejana, Elisabetta
Article

Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression

Cancer Research, v. 79, (17), September 2019, p. 4399-4411
He, Lingli; Yuan, Liang; Sun, Yang; Wang, Pingyang; Zhang, Hailin; Feng, Xue; Wang, Zuoyun; Zhang, Wenxiang; Yang, Chuanyu; Zeng, Yi Arial; Zhao, Yun; Chen, Ceshi; Zhang, Lei
Article

Hormones Induce the Formation of Luminal-derived Basal Cells in the Mammary Gland

Cell Research, v. 29, (3), March 2019, p. 206-220
Song, Wenqian; Wang, Ran; Jiang, Weimin; Yin, Qi; Peng, Guangdun; Yang, Ruikai; Yu, Qing Cissy; Chen, Jianfeng; Li, Jingsong; Cheung, Hiu Tung; Jing, Naihe; Zeng, Yi Arial
Article

Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

Nature Genetics, v. 51, (4), February 2019, p. 728-738
Liu, Qiaozhen; Zeng, Yi Arial; Peng, Guangdun; Ji, Hongbin; Zhou, Bin
Article

Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium

Nature Communications, v. 10, (1), October 2019, article number 4966
Wang, Jingqiang; Wang, Daisong; Chu, Kun; Li, Wen; Zeng, Yi Arial
Article

Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers

Cell Research, v. 29, (10), September 2019, p. 832-845
Wang, Daisong; Shao, Zhi-Ming; Zeng, Yi Arial
Article

2018 2

Protein C receptor stimulates multiple signaling pathways in breast cancer cells

Journal of Biological Chemistry, v. 293, (4), January 2018, p. 1413-1424
Wang, Daisong; Liu, Chunye; Wang, Jingqiang; Jia, Yingying; Hu, Xin; Jiang, Hai; Shao, Zhi-Ming; Zeng, Yi Arial
Article

Th-POK regulates mammary gland lactation through mTOR-SREBP pathway

PLoS Genetics, v. 14, (2), February 2018, article number e1007211
Zhang, Rui; Ma, Huimin; Gao, Yuan; Wu, Yanjun; Qiao, Yuemei; Geng, Ajun; Cai, Cheguo; Han, Yingying; Zeng, Yi Arial; Liu, Xiaolong; Ge, Gaoxiang
Article

2017 2

A Novel Mammary Fat Pad Transplantation Technique to Visualize the Vessel Generation of Vascular Endothelial Stem Cells

Journal of Visualized Experiments, (126), August 2017, article number e55795
Yu, Qing Cissy; Song, Wenqian; Lai, Dengwen; Zeng, Yi Arial
Article

Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells

Scientific Reports, v. 7, (1), September 2017, article number 10941
Liu, Wei; Wu, Ting; Dong, Xiaobing; Zeng, Yi Arial
Article

2016 2

Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells

PLoS Genetics, v. 12, (5), May 2016, article number e1006055
Zeng, Liyong; Cai, Cheguo; Li, Shan; Wang, Wenjuan; Li, Yaping; Chen, Jiangye; Zhu, Xueliang; Zeng, Yi Arial
Article

Mammary Development and Breast Cancer: A Wnt Perspective

Cancers, v. 8, (7), July 2016, article number 65
Yu, Qing Cissy; Verheyen, Esther M.; Zeng, Yi Arial
Article

2015 1

Identification of multipotent mammary stem cells by protein C receptor expression

Nature, v. 517, (7532), January 2015, p. 81-84
Wang, Daisong; Cai, Cheguo; Dong, Xiaobing; Yu, Qing Cissy; Zhang, Xiao-Ou; Yang, Li; Zeng, Yi Arial
Article

2014 2

R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal

Genes and Development, v. 28, (20), October 2014, p. 2205-2218
Cai, Cheguo; Yu, Qing Cissy; Jiang, Weimin; Liu, Wei; Song, Wenqian; Yu, Hua; Zhang, Lei; Yang, Ying; Zeng, Yi Arial
Article

SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

Stem Cell Reports, v. 3, (3), September 2014, p. 385-393
Harburg, Gwyndolen; Compton, Jennifer; Liu, Wei; Iwai, Naomi; Zada, Shahrzad; Marlow, Rebecca; Strickland, Phyllis; Zeng, Yi Arial; Hinck, Lindsay
Article

2013 1

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells

Development (Cambridge), v. 140, (6), March 2013, p. 1196-1206
Jan, Taha Adnan; Chai, Renjie; Sayyid, Zahra Nabi; van Amerongen, Renée; Xia, Anping; Wang, Tian; Sinkkonen, Saku Tapani; Zeng, Yi Arial; Levin, Jared Ruben; Heller, Stefan; Nusse, Roel; Cheng, Alan Gi-Lun
Article

2010 2

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

Cell Stem Cell, v. 6, (6), June 2010, p. 568-577
Zeng, Yi Arial; Nusse, Roel
Article

Wnt Proteins Promote Bone Regeneration

Science Translational Medicine, v. 2, (29), 2010, p. 29
Minear, Steven; Leucht, Philipp; Jiang, Jie; Liu, Bo; Zeng, Yi Arial; Fuerer, Christophe; Nusse, Roel; Helms, Jill A.
Article

2008 2

Inhibition of Drosophila Wg Signaling Involves Competition between Mad and Armadillo/β-Catenin for dTcf Binding

PLoS ONE, v. 3, (12), December 2008, article number e3893
Zeng, Yi Arial; Rahnama, Maryam; Wang, Simon; Lee, Wendy; Verheyen, Ester M.
Article

Wnt Signaling and Stem Cell Control

Cold Spring Harbor Symposia on Quantitative Biology, v. 73, January 2008, p. 59-66
Nusse, R.; Fuerer, C.; Ching, W.; Harnish, K.; Logan, C.; Zeng, A.; Ten Berge, D.; Kalani, Y.
Article

2007 1

Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad inhibition of its nuclear accumulation

Development, v. 134, (11), June 2007, p. 2061-2071
Zeng, Yi Arial; Rahnama, Maryam; Wang, Simon; Sosu-Sedzorme, Worlanyo; Verheyen, Esther M.
Article

2004 1

Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development

Development, v. 131, (12), June 2004, p. 2911-2920
Zeng, Yi A.; Verheyen, Esther M.
Article

Article 2

Ca²⁺ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds

Nature Communications, v. 15, (1), July 2024, article number 6131
Li, Yue; Wang, ShiHui; Zhang, YouHua; Liu, ZhaoYuan; Zheng, YunZhe; Zhang, Kun; Chen, ShiYang; Lv, XiaoYing; Huang, MengWen; Pan, XingChao; Zheng, YaJuan; Yuan, MengYa; Ge, GaoXiang; Zeng, Yi Arial; Lin, ChangDong; Chen, JianFeng

Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress

Cell Stem Cell, v. 31, (1), January 2024, p. 89-105.e6
Liu, Chunye; Xu, Yishu; Yang, Guowei; Tao, Yu; Chang, Jiali; Wang, Shihui; Cheung, Hiu Tung; Chen, Jianfeng; Zeng, Yi Arial

Article 3

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity

Advanced Science, v. 10, (12), April 2023, article number 2207152
Sun, Yingkai; Zhang, Juan; Hong, Jie; Zhang, Zhongyun; Lu, Peng; Gao, Aibo; Ni, Mengshan; Zhang, Zhiyin; Yang, Huanjie; Shen, Juan; Lu, Jieli; Xue, Wenzhi; Lv, Qianqian; Bi, Yufang; Zeng, Yi Arial; Gu, Weiqiong; Ning, Guang; Wang, Weiqing; Liu, Ruixin; Wang, Jiqiu

LRP12 is an endogenous transmembrane inactivator of α4 integrins

Cell Reports, v. 42, (6), June 2023, article number 112667
Huang, MengWen; Lu, Ling; Lin, ChangDong; Zheng, YaJuan; Pan, XingChao; Wang, ShiHui; Chen, ShiYang; Zhang, YouHua; Liu, ChunYe; Ge, GaoXiang; Zeng, Yi Arial; Chen, JianFeng

Progress and challenges in stem cell biology

Nature Cell Biology, v. 25, (2), February 2023, p. 203-206
Apostolou, Effie; Blau, Helen; Chien, Kenneth; Lancaster, Madeline A.; Tata, Purushothama Rao; Trompouki, Eirini; Watt, Fiona M.; Zeng, Yi Arial; Zernicka-Goetz, Magdalena

Article 10

Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry

Cell Reports, v. 41, (8), November 2022, article number 111694
Yu, Qing Cissy; Geng, Ajun; Preusch, Christopher B.; Chen, Yujie; Peng, Guangdun; Xu, Yishu; Jia, Yingying; Miao, Yi; Xue, Huaqing; Gao, Dong; Bao, Lan; Pan, Weijun; Chen, Jianfeng; Garcia, K. Christopher; Cheung, Tom H.; Zeng, Yi Arial

Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3

Oncogene, v. 41, (34), August 2022, p. 4091-4103
Liu, Cui; Wang, JunLei; Zheng, YaJuan; Zhu, Yue; Zhou, ZhengHang; Liu, ZhaoYuan; Lin, ChangDong; Wan, YaoYing; Wen, YaTing; Liu, ChunYe; Yuan, MengYa; Zeng, Yi Arial; Yan, ZhanJun; Ge, GaoXiang; Chen, JianFeng

CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression

Cell Reports, v. 40, (11), September 2022, article number 111331
Zhang, Mengna; Zhang, Lingxian; Geng, Ajun; Li, Xiao; Zhou, Yu; Xu, Liming; Zeng, Yi Arial; Li, Jinpeng; Cai, Cheguo

Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

Cell Reports, v. 38, (2), January 2022, article number 110240
Han, Yingying; Villarreal-Ponce, Alvaro; Gutierrez, Guadalupe; Nguyen, Quy; Sun, Peng; Wu, Ting; Sui, Benjamin; Berx, Geert; Brabletz, Thomas; Kessenbrock, Kai; Zeng, Yi Arial; Watanabe, Kazuhide; Dai, Xing

Embryonic vascular establishment requires protein C receptor-expressing endothelial progenitors

Development (Cambridge), v. 149, (12), June 2022, article number dev200419
Yu, Qing Cissy; Bai, Lanyue; Chen, Yingying; Chen, Yujie; Peng, Guangdun; Wang, Daisong; Yang, Guowei; Cui, Guizhong; Jing, Naihe; Zeng, Yi Arial

Functional hepatobiliary organoids recapitulate liver development and reveal essential drivers of hepatobiliary cell fate determination

Life Medicine, v. 1, (3), December 2022, p. 345-358
He, Juan; Cui, Haoyue; Shi, Xiaohan; Jin, Qiqi; Han, Ximeng; Han, Tiantian; Peng, Jiayin; Guo, Shiwei; Zhang, Lei; Zhao, Yun; Zhou, Bin; Chen, Luonan; Chen, Lei; Zeng, Yi Arial; Wang, Hongyang; Jin, Gang; Gao, Dong

Isolation of mouse pancreatic islet Procr⁺ progenitors and long-term expansion of islet organoids in vitro

Nature Protocols, v. 17, (5), May 2022, p. 1359-1384
Wang, Jingqiang; Wang, Daisong; Chen, Xinyi; Yuan, Shubo; Bai, Lanyue; Liu, Chunye; Zeng, Yi Arial

Organoids

Nature Reviews Methods Primers, v. 2, (1), December 2022 , article number 94
Zhao, Zixuan; Chen, Xinyi; Dowbaj, Anna M.; Sljukic, Aleksandra; Bratlie, Kaitlin; Lin, Luda; Fong, Eliza Li Shan; Balachander, Gowri Manohari; Chen, Zhaowei; Soragni, Alice; Huch, Meritxell; Zeng, Yi Arial; Wang, Qun; Yu, Hanry

Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells

Cell Reports, v. 38, (12), March 2022, article number 110548
Liu, Chunye; Lin, Changdong; Wang, Daisong; Wang, Jingqiang; Tao, Yu; Li, Yue; Chen, Xinyi; Bai, Lanyue; Jia, Yingying; Chen, Jianfeng; Zeng, Yi Arial

Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair

eLife, v. 11, March 2022, article number e75449
Wang, Jingqiang; Liu, Chunye; He, Lingli; Xie, Zhiyao; Bai, Lanyue; Yu, Wentao; Wang, Zuoyun; Lu, Yi; Gao, Dong; Fu, Junfen; Zhang, Lei; Zeng, Yi Arial

Article 8

Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model

Nucleic Acids Research, v. 49, (2), January 2021, p. 726-744
Hung, Yu-Han; Huang, Sha; Dame, Michael K; Yu, Qianhui; Yu, Qing C; Zeng, Yi A; Camp, J. Gray; Spence, Jason R; Sethupathy, Praveen

Endothelial Wnts control mammary epithelial patterning via fibroblast signaling

Cell Reports, v. 34, (13), March 2021, article number 108897
Wang, Jingqiang; Song, Wenqian; Yang, Ruikai; Li, Chao; Wu, Ting; Dong, Xiao Bing; Zhou, Bin; Guo, Xizhi; Chen, Jianfeng; Liu, Zhiyong; Yu, Qing Cissy; Li, Wen; Fu, Junfen; Zeng, Yi Arial

Integrin αEβ7⁺ T cells direct intestinal stem cell fate decisions via adhesion signaling

Cell Research, v. 31, (12), December 2021, p. 1291-1307
Chen, Shiyang; Zheng, Yajuan; Ran, Xiaojuan; Du, Hui; Feng, Hua; Yang, Lei; Wen, Yating; Lin, Changdong; Wang, Shihui; Huang, Mengwen; Yan, Zhanjun; Wu, Dianqing; Wang, Hongyan; Ge, Gaoxiang; Zeng, An; Zeng, Yi Arial; Chen, Jianfeng

Lentiviral CRISPR-guided RNA library screening identified Adam17 as an upstream negative regulator of Procr in mammary epithelium

BMC Biotechnology, v. 21, (1), July 2021, article number 42
Wu, Ting; Wang, Yinghua; Xiao, Tianxiong; Ai, Yirui; Li, Jinsong; Zeng, Yi Arial; Yu, Qing Cissy

MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche

Nature, v. 592, (7855), April 2021, p. 606-610
Wu, Ningbo; Zeng, Yi Arial; Su, Bing

Preface to the special topic on tissue stem cell research

Science China Life Sciences, v. 64, (12), December 2021, p. 1995-1997
Li, Jinsong; Zeng, Yi Arial

Recent advances in tissue stem cells

Science China Life Sciences, v. 64, (12), December 2021, p. 1998-2029
Fu, Xin; He, Qiang; Tao, Yu; Wang, Mengdi; Wang, Wei; Wang, Yalong; Yu, Qing Cissy; Zhang, Fang; Zhang, Xiaoyu; Chen, Ye-Guang; Gao, Dong; Hu, Ping; Hui, Lijian; Wang, Xiaoqun; Zeng, Yi Arial

SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling

Protein and Cell, v. 12, (3), March 2021, p. 174-193
Xu, Liang; Li, Peixue; Hao, Xue; Lu, Yi; Liu, Mingxian; Song, Wenqian; Shan, Lin; Yu, Jiao; Ding, Hongyu; Chen, Shishuang; Yang, Ailing; Zeng, Yi Arial; Zhang, Lei; Jiang, Hai

Article 5

A mutation that blocks integrin α₄β₇activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis

BMC Biology, v. 18, (1), June 2020, article number 64
Zhang, Hailong; Zheng, Yajuan; Pan, Youdong; Lin, Changdong; Wang, Shihui; Yan, Zhanjun; Lu, Ling; Ge, Gaoxiang; Li, Jinsong; Zeng, Yi Arial; Chen, Jianfeng

A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling

eLife, v. 9, August 2020, p. 1-20
Geng, Ajun; Wu, Ting; Cai, Cheguo; Song, Wenqian; Wang, Jiqiu; Yu, Qing Cissy; Zeng, Yi Arial

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

Cell Reports, v. 33, (3), October 2020, article number 108284
He, Lingli; Yuan, Liang; Yu, Wentao; Sun, Yang; Jiang, Dan; Wang, Xiaodong; Feng, Xue; Wang, Zuoyun; Xu, Jinjin; Yang, Ruizeng; Zhang, Wenxiang; Feng, Hua; Chen, Hang-zi; Zeng, Yi Arial; Hui, Lijian; Wu, Qiao; Zhang, Yonglong; Zhang, Lei

Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland

Developmental Biology, v. 458, (1), February 2020, p. 43-51
Cai, Cheguo; Geng, Ajun; Wang, Mengran; Yang, Li; Yu, Qing Cissy; Zeng, Yi Arial

Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr⁺ Progenitors

Cell, v. 180, (6), March 2020, p. 1198-1211.e19
Wang, Daisong; Wang, Jingqiang; Bai, Lanyue; Pan, Hong; Feng, Hua; Clevers, Hans; Zeng, Yi Arial

Article 6

Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Nature Communications, v. 10, (1), June 2019, article number 2761
Malinverno, Matteo; Maderna, Claudio; Abu Taha, Abdallah; Corada, Monica; Orsenigo, Fabrizio; Valentino, Mariaelena; Pisati, Federica; Fusco, Carmela; Graziano, Paolo; Giannotta, Monica; Yu, Qing Cissy; Zeng, Yi Arial; Lampugnani, Maria Grazia; Magnusson, Peetra U.; Dejana, Elisabetta

Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression

Cancer Research, v. 79, (17), September 2019, p. 4399-4411
He, Lingli; Yuan, Liang; Sun, Yang; Wang, Pingyang; Zhang, Hailin; Feng, Xue; Wang, Zuoyun; Zhang, Wenxiang; Yang, Chuanyu; Zeng, Yi Arial; Zhao, Yun; Chen, Ceshi; Zhang, Lei

Hormones Induce the Formation of Luminal-derived Basal Cells in the Mammary Gland

Cell Research, v. 29, (3), March 2019, p. 206-220
Song, Wenqian; Wang, Ran; Jiang, Weimin; Yin, Qi; Peng, Guangdun; Yang, Ruikai; Yu, Qing Cissy; Chen, Jianfeng; Li, Jingsong; Cheung, Hiu Tung; Jing, Naihe; Zeng, Yi Arial

Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

Nature Genetics, v. 51, (4), February 2019, p. 728-738
Liu, Qiaozhen; Zeng, Yi Arial; Peng, Guangdun; Ji, Hongbin; Zhou, Bin

Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium

Nature Communications, v. 10, (1), October 2019, article number 4966
Wang, Jingqiang; Wang, Daisong; Chu, Kun; Li, Wen; Zeng, Yi Arial

Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers

Cell Research, v. 29, (10), September 2019, p. 832-845
Wang, Daisong; Shao, Zhi-Ming; Zeng, Yi Arial

Article 2

Protein C receptor stimulates multiple signaling pathways in breast cancer cells

Journal of Biological Chemistry, v. 293, (4), January 2018, p. 1413-1424
Wang, Daisong; Liu, Chunye; Wang, Jingqiang; Jia, Yingying; Hu, Xin; Jiang, Hai; Shao, Zhi-Ming; Zeng, Yi Arial

Th-POK regulates mammary gland lactation through mTOR-SREBP pathway

PLoS Genetics, v. 14, (2), February 2018, article number e1007211
Zhang, Rui; Ma, Huimin; Gao, Yuan; Wu, Yanjun; Qiao, Yuemei; Geng, Ajun; Cai, Cheguo; Han, Yingying; Zeng, Yi Arial; Liu, Xiaolong; Ge, Gaoxiang

Article 2

A Novel Mammary Fat Pad Transplantation Technique to Visualize the Vessel Generation of Vascular Endothelial Stem Cells

Journal of Visualized Experiments, (126), August 2017, article number e55795
Yu, Qing Cissy; Song, Wenqian; Lai, Dengwen; Zeng, Yi Arial

Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells

Scientific Reports, v. 7, (1), September 2017, article number 10941
Liu, Wei; Wu, Ting; Dong, Xiaobing; Zeng, Yi Arial

Article 2

Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells

PLoS Genetics, v. 12, (5), May 2016, article number e1006055
Zeng, Liyong; Cai, Cheguo; Li, Shan; Wang, Wenjuan; Li, Yaping; Chen, Jiangye; Zhu, Xueliang; Zeng, Yi Arial

Mammary Development and Breast Cancer: A Wnt Perspective

Cancers, v. 8, (7), July 2016, article number 65
Yu, Qing Cissy; Verheyen, Esther M.; Zeng, Yi Arial

Article 1

Identification of multipotent mammary stem cells by protein C receptor expression

Nature, v. 517, (7532), January 2015, p. 81-84
Wang, Daisong; Cai, Cheguo; Dong, Xiaobing; Yu, Qing Cissy; Zhang, Xiao-Ou; Yang, Li; Zeng, Yi Arial

Article 2

R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal

Genes and Development, v. 28, (20), October 2014, p. 2205-2218
Cai, Cheguo; Yu, Qing Cissy; Jiang, Weimin; Liu, Wei; Song, Wenqian; Yu, Hua; Zhang, Lei; Yang, Ying; Zeng, Yi Arial

SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

Stem Cell Reports, v. 3, (3), September 2014, p. 385-393
Harburg, Gwyndolen; Compton, Jennifer; Liu, Wei; Iwai, Naomi; Zada, Shahrzad; Marlow, Rebecca; Strickland, Phyllis; Zeng, Yi Arial; Hinck, Lindsay

Article 1

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells

Development (Cambridge), v. 140, (6), March 2013, p. 1196-1206
Jan, Taha Adnan; Chai, Renjie; Sayyid, Zahra Nabi; van Amerongen, Renée; Xia, Anping; Wang, Tian; Sinkkonen, Saku Tapani; Zeng, Yi Arial; Levin, Jared Ruben; Heller, Stefan; Nusse, Roel; Cheng, Alan Gi-Lun

Article 2

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

Cell Stem Cell, v. 6, (6), June 2010, p. 568-577
Zeng, Yi Arial; Nusse, Roel

Wnt Proteins Promote Bone Regeneration

Science Translational Medicine, v. 2, (29), 2010, p. 29
Minear, Steven; Leucht, Philipp; Jiang, Jie; Liu, Bo; Zeng, Yi Arial; Fuerer, Christophe; Nusse, Roel; Helms, Jill A.

Article 2

Inhibition of Drosophila Wg Signaling Involves Competition between Mad and Armadillo/β-Catenin for dTcf Binding

PLoS ONE, v. 3, (12), December 2008, article number e3893
Zeng, Yi Arial; Rahnama, Maryam; Wang, Simon; Lee, Wendy; Verheyen, Ester M.

Wnt Signaling and Stem Cell Control

Cold Spring Harbor Symposia on Quantitative Biology, v. 73, January 2008, p. 59-66
Nusse, R.; Fuerer, C.; Ching, W.; Harnish, K.; Logan, C.; Zeng, A.; Ten Berge, D.; Kalani, Y.

Article 1

Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad inhibition of its nuclear accumulation

Development, v. 134, (11), June 2007, p. 2061-2071
Zeng, Yi Arial; Rahnama, Maryam; Wang, Simon; Sosu-Sedzorme, Worlanyo; Verheyen, Esther M.

Article 1

Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development

Development, v. 131, (12), June 2004, p. 2911-2920
Zeng, Yi A.; Verheyen, Esther M.

2019 6

Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Nature Communications, v. 10, (1), June 2019, article number 2761
Malinverno, Matteo; Maderna, Claudio; Abu Taha, Abdallah; Corada, Monica; Orsenigo, Fabrizio; Valentino, Mariaelena; Pisati, Federica; Fusco, Carmela; Graziano, Paolo; Giannotta, Monica; Yu, Qing Cissy; Zeng, Yi Arial; Lampugnani, Maria Grazia; Magnusson, Peetra U.; Dejana, Elisabetta
Article

Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression

Cancer Research, v. 79, (17), September 2019, p. 4399-4411
He, Lingli; Yuan, Liang; Sun, Yang; Wang, Pingyang; Zhang, Hailin; Feng, Xue; Wang, Zuoyun; Zhang, Wenxiang; Yang, Chuanyu; Zeng, Yi Arial; Zhao, Yun; Chen, Ceshi; Zhang, Lei
Article

Hormones Induce the Formation of Luminal-derived Basal Cells in the Mammary Gland

Cell Research, v. 29, (3), March 2019, p. 206-220
Song, Wenqian; Wang, Ran; Jiang, Weimin; Yin, Qi; Peng, Guangdun; Yang, Ruikai; Yu, Qing Cissy; Chen, Jianfeng; Li, Jingsong; Cheung, Hiu Tung; Jing, Naihe; Zeng, Yi Arial
Article

Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

Nature Genetics, v. 51, (4), February 2019, p. 728-738
Liu, Qiaozhen; Zeng, Yi Arial; Peng, Guangdun; Ji, Hongbin; Zhou, Bin
Article

Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium

Nature Communications, v. 10, (1), October 2019, article number 4966
Wang, Jingqiang; Wang, Daisong; Chu, Kun; Li, Wen; Zeng, Yi Arial
Article

Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers

Cell Research, v. 29, (10), September 2019, p. 832-845
Wang, Daisong; Shao, Zhi-Ming; Zeng, Yi Arial
Article

2018 2

Protein C receptor stimulates multiple signaling pathways in breast cancer cells

Journal of Biological Chemistry, v. 293, (4), January 2018, p. 1413-1424
Wang, Daisong; Liu, Chunye; Wang, Jingqiang; Jia, Yingying; Hu, Xin; Jiang, Hai; Shao, Zhi-Ming; Zeng, Yi Arial
Article

Th-POK regulates mammary gland lactation through mTOR-SREBP pathway

PLoS Genetics, v. 14, (2), February 2018, article number e1007211
Zhang, Rui; Ma, Huimin; Gao, Yuan; Wu, Yanjun; Qiao, Yuemei; Geng, Ajun; Cai, Cheguo; Han, Yingying; Zeng, Yi Arial; Liu, Xiaolong; Ge, Gaoxiang
Article

2017 2

A Novel Mammary Fat Pad Transplantation Technique to Visualize the Vessel Generation of Vascular Endothelial Stem Cells

Journal of Visualized Experiments, (126), August 2017, article number e55795
Yu, Qing Cissy; Song, Wenqian; Lai, Dengwen; Zeng, Yi Arial
Article

Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells

Scientific Reports, v. 7, (1), September 2017, article number 10941
Liu, Wei; Wu, Ting; Dong, Xiaobing; Zeng, Yi Arial
Article

2016 2

Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells

PLoS Genetics, v. 12, (5), May 2016, article number e1006055
Zeng, Liyong; Cai, Cheguo; Li, Shan; Wang, Wenjuan; Li, Yaping; Chen, Jiangye; Zhu, Xueliang; Zeng, Yi Arial
Article

Mammary Development and Breast Cancer: A Wnt Perspective

Cancers, v. 8, (7), July 2016, article number 65
Yu, Qing Cissy; Verheyen, Esther M.; Zeng, Yi Arial
Article

2015 1

Identification of multipotent mammary stem cells by protein C receptor expression

Nature, v. 517, (7532), January 2015, p. 81-84
Wang, Daisong; Cai, Cheguo; Dong, Xiaobing; Yu, Qing Cissy; Zhang, Xiao-Ou; Yang, Li; Zeng, Yi Arial
Article

2014 2

R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal

Genes and Development, v. 28, (20), October 2014, p. 2205-2218
Cai, Cheguo; Yu, Qing Cissy; Jiang, Weimin; Liu, Wei; Song, Wenqian; Yu, Hua; Zhang, Lei; Yang, Ying; Zeng, Yi Arial
Article

SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

Stem Cell Reports, v. 3, (3), September 2014, p. 385-393
Harburg, Gwyndolen; Compton, Jennifer; Liu, Wei; Iwai, Naomi; Zada, Shahrzad; Marlow, Rebecca; Strickland, Phyllis; Zeng, Yi Arial; Hinck, Lindsay
Article

2013 1

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells

Development (Cambridge), v. 140, (6), March 2013, p. 1196-1206
Jan, Taha Adnan; Chai, Renjie; Sayyid, Zahra Nabi; van Amerongen, Renée; Xia, Anping; Wang, Tian; Sinkkonen, Saku Tapani; Zeng, Yi Arial; Levin, Jared Ruben; Heller, Stefan; Nusse, Roel; Cheng, Alan Gi-Lun
Article

2010 2

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

Cell Stem Cell, v. 6, (6), June 2010, p. 568-577
Zeng, Yi Arial; Nusse, Roel
Article

Wnt Proteins Promote Bone Regeneration

Science Translational Medicine, v. 2, (29), 2010, p. 29
Minear, Steven; Leucht, Philipp; Jiang, Jie; Liu, Bo; Zeng, Yi Arial; Fuerer, Christophe; Nusse, Roel; Helms, Jill A.
Article

2008 2

Inhibition of Drosophila Wg Signaling Involves Competition between Mad and Armadillo/β-Catenin for dTcf Binding

PLoS ONE, v. 3, (12), December 2008, article number e3893
Zeng, Yi Arial; Rahnama, Maryam; Wang, Simon; Lee, Wendy; Verheyen, Ester M.
Article

Wnt Signaling and Stem Cell Control

Cold Spring Harbor Symposia on Quantitative Biology, v. 73, January 2008, p. 59-66
Nusse, R.; Fuerer, C.; Ching, W.; Harnish, K.; Logan, C.; Zeng, A.; Ten Berge, D.; Kalani, Y.
Article

2007 1

Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad inhibition of its nuclear accumulation

Development, v. 134, (11), June 2007, p. 2061-2071
Zeng, Yi Arial; Rahnama, Maryam; Wang, Simon; Sosu-Sedzorme, Worlanyo; Verheyen, Esther M.
Article

2004 1

Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development

Development, v. 131, (12), June 2004, p. 2911-2920
Zeng, Yi A.; Verheyen, Esther M.
Article

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