Faculty Profiles - MIAO Yi | The Hong Kong University of Science and Technology

Yi MIAO
繆義

PhD in Biochemistry
Duke University, 2016

Assistant Professor
Division of Life Science

(852) 2358 7307
yimiao@ust.hk
Room 5463
Personal Web

Google Scholar

Rspedx8AAAAJ

ORCID

0000-0003-0738-6041

ResearcherID

JYQ-8574-2024

Scopus ID

57204030522

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Cell signaling
Structural biology
Molecular medicine
Stem cell biology
Neuroscience

Publications

All Years 25 2026 3 2025 3 2024 1 2023 1 2022 4 2021 1 2020 12

2026 3

BAI adhesion-GPCRs perform distinct functions in neural development differentially controlled by RTN4R and C1ql ligands

Nature Communications, v. 17, (1), article number 6140
WANG, Jie; Wang, Jinzhao; MIAO, Yi; Li, Yang; Zhu, Shaoyuan; ZHANG, Yu; Yousif, Ahmed; Huang, Min; Wernig, Marius; Südhof, Thomas C.
Article

Tethered agonist- and GAIN domain-independent signaling of an adhesion GPCR

Science Advances, v. 12, (27), p. eadu3822
WANG, Jie; MIAO, Yi; Wang, Jinzhao; Zhu, Shaoyuan; ZHANG, Yu; WONG, Tsz Lok; Yousif, Ahmed; Wernig, Marius; Südhof, Thomas C.
Article

Two parallel neural ectoderm progenitors contribute to the developing brain

Nature Neuroscience
Jokhai, Rayyan T.; Dundes, Carolyn E.; Ahsan, Hadia S.; Kang, Rachel S.; Salomon-Shulman, Rachel E.A.; Rajan, Arjun; Kim, Yoon Seok; Stanton, Liam J.; Xu, Christine; Do, Stephanie; McDonald, Brennan D.; Andrade López, José Miguel; Urrutia, Hugo A.; Greenfeld, Hannah; Wong, Alicia; Qu, Yimiao; Petkovic, Andrew S.; Miao, Yi; Garcia, K. Christopher; Monje, Michelle; Wagner, Daniel E.; Bronner, Marianne E.; Lowe, Christopher J.; Loh, Kyle M.
Article

2025 3

FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist response

Developmental Cell, v. 60, (3), p. 342-351.e5
Mu, Qinghui; Ha, Andrew; Santos, Antonio J.M.; Lo, Yuan Hung; van Unen, Vincent; Miao, Yi; Tomaske, Madeline; Guzman, Veronica K.; Alwahabi, Samira; Yuan, Jenny J.; Deng, Lu; Li, Linheng; Garcia, K. Christopher; Kuo, Calvin J.
Article

Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways

mBio, v. 16, (10), p. 1-17
Miao, Yi; Yadav, Vikas; Shadrick, William; Liu, Jiuyu; Jenner, Alexander R.; Nichols, Connie B.; Gee, Clifford; Schäfer, Martin; Tenor, Jennifer L.; Perfect, John R.; Lee, Richard E.; Brennan, Richard G.; Washington, Erica J.
Article

Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3

Communications Biology, v. 8, (1), p. 1-6, article number 693
Miao, Yi; Wang, Haoqing; Jude, Kevin M.; Wang, Jie; Wang, Jinzhao; Wernig, Marius; Südhof, Thomas C.
Article

2024 1

TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling

Stem Cell Reports, v. 19, (7), p. 973-992
Funa, Nina Sofi; Mjoseng, Heidi Katharina; de Lichtenberg, Kristian Honnens; Raineri, Silvia; Esen, Deniz; Egeskov-Madsen, Anuska la Rosa; Quaranta, Roberto; Jørgensen, Mette Christine; Hansen, Maria Skjøtt; van Cuyl Kuylenstierna, Jonas; Jensen, Kim Bak; Miao, Yi; Garcia, K. Christopher; Seymour, Philip A.; Serup, Palle
Article

2023 1

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination

Proceedings of the National Academy of Sciences of the United States of America, v. 120, (11), article number e2218238120
Tsutsumi, Naotaka; Hwang, Sunhee; Waghray, Deepa; Hansen, Simon; Judea, Kevin M.; Wang, Nan; Miao, Yi; Glassman, Caleb R.; Caveney, Nathanael A.; Janda, Claudia Y.; Hannoush, Rami N.; Garcia, K. Christopher
Article

2022 4

Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry

Cell Reports, v. 41, (8), article number 111694
Yu, Qing Cissy; Geng, Ajun; Preusch, Christopher B.; Chen, Yujie; Peng, Guangdun; Xu, Yishu; Jia, Yingying; Miao, Yi; Xue, Huaqing; Gao, Dong; Bao, Lan; Pan, Weijun; Chen, Jianfeng; Garcia, K. Christopher; Cheung, Tom H.; Zeng, Yi Arial
Article

Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets

Small, v. 18, (50), article number 2203723
Philippi, Michael; Richter, Christian P.; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspötter, Michael; Kurre, Rainer; Holthuis, Joost C.M.; Garcia, K. Christopher; Plückthun, Andreas; Steinhart, Martin; Piehler, Jacob; You, Changjiang
Article

Erratum: RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development (Cell (2021) 184(24) (5869–5885.e25), (S0092867421012320), (10.1016/j.cell.2021.10.016))

Cell, v. 185, (1), p. 218
Wang, Jie; Miao, Yi; Wicklein, Rebecca; Sun, Zijun; Wang, Jinzhao; Jude, Kevin M.; Fernandes, Ricardo A.; Merrill, Sean A.; Wernig, Marius; Garcia, K. Christopher; Südhof, Thomas C.
Article

Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling

Nature Communications, v. 13, (1), article number 715
Maimets, Martti; Pedersen, Marianne Terndrup; Guiu, Jordi; Dreier, Jes; Thodberg, Malte; Antoku, Yasuko; Schweiger, Pawel J.; Rib, Leonor; Bressan, Raul Bardini; Miao, Yi; Garcia, K. Christopher; Sandelin, Albin; Serup, Palle; Jensen, Kim B.
Article

2021 1

RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development

Cell, v. 184, (24), p. 5869-5885.e25
Wang, Jie; Miao, Yi; Wicklein, Rebecca; Sun, Zijun; Wang, Jinzhao; Jude, Kevin M.; Fernandes, Ricardo A.; Merrill, Sean A.; Wernig, Marius; Garcia, K. Christopher; Südhof, Thomas C.
Article

2020 4

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Cell Stem Cell, v. 27, (5), p. 840-851.e6
Miao, Yi; Ha, Andrew; de Lau, Wim; Yuki, Kanako; Santos, António J.M.; You, Changjiang; Geurts, Maarten H.; Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Peng, Weng Chuan; Senlice, Ramazan; Piani, Carol; Buikema, Jan W.; Gbenedio, Oghenekevwe M.; Vallon, Mario; Yuan, Jenny; de Haan, Sanne; Hemrika, Wieger; Rösch, Kathrin; Dang, Luke T.; Baker, David; Ott, Melanie; Depeille, Philippe; Wu, Sean M.; Drost, Jarno; Nusse, Roeland; Roose, Jeroen P.; Piehler, Jacob; Boj, Sylvia F.; Janda, Claudia Y.; Clevers, Hans; Kuo, Calvin J.; Garcia, K. Christopher
Article

Structure of human frizzled5 by fiducial-assisted cryo-em supports a heterodimeric mechanism of canonical wnt signaling

eLife, v. 9, p. 1-20, article number e58464
Tsutsumi, Naotaka; Mukherjee, Somnath; Waghray, Deepa; Janda, Claudia Y.; Jude, Kevin M.; Miao, Yi; Burg, John S.; Aduri, Nanda Gowtham; Kossiakoff, Anthony A.; Gati, Cornelius; Garcia, K. Christopher
Article

Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling

PLoS ONE, v. 15, (1), article number e0226928
Luca, Vincent C.; Miao, Yi; Li, Xingnan; Hollander, Michael J.; Kuo, Calvin J.; Christopher Garcia, K.
Article

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Cell Stem Cell, v. 27, (1), p. 50-63.e5
Buikema, Jan W.; Lee, Soah; Goodyer, William R.; Maas, Renee G.; Chirikian, Orlando; Li, Guang; Miao, Yi; Paige, Sharon L.; Lee, Daniel; Wu, Haodi; Paik, David T.; Rhee, Siyeon; Tian, Lei; Galdos, Francisco X.; Puluca, Nazan; Beyersdorf, Benjamin; Hu, James; Beck, Aimee; Venkamatran, Sneha; Swami, Srilatha; Wijnker, Paul; Schuldt, Maike; Dorsch, Larissa M.; van Mil, Alain; Red-Horse, Kristy; Wu, Joy Y.; Geisen, Caroline; Hesse, Michael; Serpooshan, Vahid; Jovinge, Stefan; Fleischmann, Bernd K.; Doevendans, Pieter A.; van der Velden, Jolanda; Garcia, K. Christopher; Wu, Joseph C.; Sluijter, Joost P.G.; Wu, Sean M.
Article

2019 3

RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer

JCI Insight, v. 4, (15), article number e127552
Gbenedio, Oghenekevwe M.; Bonnans, Caroline; Grun, Delphine; Wang, Chih Yang; Hatch, Ace J.; Mahoney, Michelle R.; Barras, David; Matli, Mary; Miao, Yi; Christopher Garcia, K.; Tejpar, Sabine; Delorenzi, Mauro; Venook, Alan P.; Nixon, Andrew B.; Warren, Robert S.; Roose, Jeroen P.; Depeille, Philippe
Article

Receptor subtype discrimination using extensive shape complementary designed interfaces

Nature Structural and Molecular Biology, v. 26, (6), p. 407-414
Dang, Luke T.; Miao, Yi; Ha, Andrew; Yuki, Kanako; Park, Keunwan; Janda, Claudia Y.; Jude, Kevin M.; Mohan, Kritika; Ha, Nhi; Vallon, Mario; Yuan, Jenny; Vilches-Moure, José G.; Kuo, Calvin J.; Garcia, K. Christopher; Baker, David
Article

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

Science, v. 364, (6442), article number eaav7532
Mohan, Kritika; Ueda, George; Kim, Ah Ram; Jude, Kevin M.; Fallas, Jorge A.; Guo, Yu; Hafer, Maximillian; Miao, Yi; Saxton, Robert A.; Piehler, Jacob; Sankaran, Vijay G.; Baker, David; Garcia, K. Christopher
Article

2018 1

A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability

Cell Reports, v. 25, (2), p. 339-349.e9
Vallon, Mario; Yuki, Kanako; Nguyen, Thi D.; Chang, Junlei; Yuan, Jenny; Siepe, Dirk; Miao, Yi; Essler, Markus; Noda, Makoto; Garcia, K. Christopher; Kuo, Calvin J.
Article

2017 2

Structural and In vivo studies on trehalose-6-phosphate synthase from pathogenic fungi provide insights into its catalytic mechanism, biological necessity, and potential for novel antifungal drug design

mBio, v. 8, (4), article number e00643-17
Miao, Yi; Tenor, Jennifer L.; Toffaletti, Dena L.; Maskarinec, Stacey A.; Liu, Jiuyu; Lee, Richard E.; Perfect, John R.; Brennan, Richard G.
Article

Trehalose pathway as an antifungal target

Virulence, v. 8, (2), p. 143-149
Perfect, John R.; Tenor, Jennifer L.; Miao, Yi; Brennan, Richard G.
Article

2016 1

Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (26), p. 7148-7153
Miaoa, Yi; Tenorb, Jennifer L.; Toffalettib, Dena L.; Washingtona, Erica J.; Liuc, Jiuyu; Shadrickc, William R.; Schumachera, Maria A.; Leec, Richard E.; Perfectb, John R.; Brennana, Richard G.
Article

2010 1

Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China

Protein & Cell, v. 1, (5), p. 491-500
Wu, Yang; Lou, Zhiyong; Miao, Yi; Yu, Yue; Dong, Hui; Peng, Wei; Bartlam, Mark; Li, Xuemei; Rao, Zihe
Article

Article 3

BAI adhesion-GPCRs perform distinct functions in neural development differentially controlled by RTN4R and C1ql ligands

Nature Communications, v. 17, (1), article number 6140
WANG, Jie; Wang, Jinzhao; MIAO, Yi; Li, Yang; Zhu, Shaoyuan; ZHANG, Yu; Yousif, Ahmed; Huang, Min; Wernig, Marius; Südhof, Thomas C.

Tethered agonist- and GAIN domain-independent signaling of an adhesion GPCR

Science Advances, v. 12, (27), p. eadu3822
WANG, Jie; MIAO, Yi; Wang, Jinzhao; Zhu, Shaoyuan; ZHANG, Yu; WONG, Tsz Lok; Yousif, Ahmed; Wernig, Marius; Südhof, Thomas C.

Two parallel neural ectoderm progenitors contribute to the developing brain

Nature Neuroscience
Jokhai, Rayyan T.; Dundes, Carolyn E.; Ahsan, Hadia S.; Kang, Rachel S.; Salomon-Shulman, Rachel E.A.; Rajan, Arjun; Kim, Yoon Seok; Stanton, Liam J.; Xu, Christine; Do, Stephanie; McDonald, Brennan D.; Andrade López, José Miguel; Urrutia, Hugo A.; Greenfeld, Hannah; Wong, Alicia; Qu, Yimiao; Petkovic, Andrew S.; Miao, Yi; Garcia, K. Christopher; Monje, Michelle; Wagner, Daniel E.; Bronner, Marianne E.; Lowe, Christopher J.; Loh, Kyle M.

Article 3

FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist response

Developmental Cell, v. 60, (3), p. 342-351.e5
Mu, Qinghui; Ha, Andrew; Santos, Antonio J.M.; Lo, Yuan Hung; van Unen, Vincent; Miao, Yi; Tomaske, Madeline; Guzman, Veronica K.; Alwahabi, Samira; Yuan, Jenny J.; Deng, Lu; Li, Linheng; Garcia, K. Christopher; Kuo, Calvin J.

Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways

mBio, v. 16, (10), p. 1-17
Miao, Yi; Yadav, Vikas; Shadrick, William; Liu, Jiuyu; Jenner, Alexander R.; Nichols, Connie B.; Gee, Clifford; Schäfer, Martin; Tenor, Jennifer L.; Perfect, John R.; Lee, Richard E.; Brennan, Richard G.; Washington, Erica J.

Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3

Communications Biology, v. 8, (1), p. 1-6, article number 693
Miao, Yi; Wang, Haoqing; Jude, Kevin M.; Wang, Jie; Wang, Jinzhao; Wernig, Marius; Südhof, Thomas C.

Article 1

TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling

Stem Cell Reports, v. 19, (7), p. 973-992
Funa, Nina Sofi; Mjoseng, Heidi Katharina; de Lichtenberg, Kristian Honnens; Raineri, Silvia; Esen, Deniz; Egeskov-Madsen, Anuska la Rosa; Quaranta, Roberto; Jørgensen, Mette Christine; Hansen, Maria Skjøtt; van Cuyl Kuylenstierna, Jonas; Jensen, Kim Bak; Miao, Yi; Garcia, K. Christopher; Seymour, Philip A.; Serup, Palle

Article 1

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination

Proceedings of the National Academy of Sciences of the United States of America, v. 120, (11), article number e2218238120
Tsutsumi, Naotaka; Hwang, Sunhee; Waghray, Deepa; Hansen, Simon; Judea, Kevin M.; Wang, Nan; Miao, Yi; Glassman, Caleb R.; Caveney, Nathanael A.; Janda, Claudia Y.; Hannoush, Rami N.; Garcia, K. Christopher

Article 4

Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry

Cell Reports, v. 41, (8), article number 111694
Yu, Qing Cissy; Geng, Ajun; Preusch, Christopher B.; Chen, Yujie; Peng, Guangdun; Xu, Yishu; Jia, Yingying; Miao, Yi; Xue, Huaqing; Gao, Dong; Bao, Lan; Pan, Weijun; Chen, Jianfeng; Garcia, K. Christopher; Cheung, Tom H.; Zeng, Yi Arial

Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets

Small, v. 18, (50), article number 2203723
Philippi, Michael; Richter, Christian P.; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspötter, Michael; Kurre, Rainer; Holthuis, Joost C.M.; Garcia, K. Christopher; Plückthun, Andreas; Steinhart, Martin; Piehler, Jacob; You, Changjiang

Erratum: RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development (Cell (2021) 184(24) (5869–5885.e25), (S0092867421012320), (10.1016/j.cell.2021.10.016))

Cell, v. 185, (1), p. 218
Wang, Jie; Miao, Yi; Wicklein, Rebecca; Sun, Zijun; Wang, Jinzhao; Jude, Kevin M.; Fernandes, Ricardo A.; Merrill, Sean A.; Wernig, Marius; Garcia, K. Christopher; Südhof, Thomas C.

Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling

Nature Communications, v. 13, (1), article number 715
Maimets, Martti; Pedersen, Marianne Terndrup; Guiu, Jordi; Dreier, Jes; Thodberg, Malte; Antoku, Yasuko; Schweiger, Pawel J.; Rib, Leonor; Bressan, Raul Bardini; Miao, Yi; Garcia, K. Christopher; Sandelin, Albin; Serup, Palle; Jensen, Kim B.

Article 1

RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development

Cell, v. 184, (24), p. 5869-5885.e25
Wang, Jie; Miao, Yi; Wicklein, Rebecca; Sun, Zijun; Wang, Jinzhao; Jude, Kevin M.; Fernandes, Ricardo A.; Merrill, Sean A.; Wernig, Marius; Garcia, K. Christopher; Südhof, Thomas C.

Article 4

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Cell Stem Cell, v. 27, (5), p. 840-851.e6
Miao, Yi; Ha, Andrew; de Lau, Wim; Yuki, Kanako; Santos, António J.M.; You, Changjiang; Geurts, Maarten H.; Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Peng, Weng Chuan; Senlice, Ramazan; Piani, Carol; Buikema, Jan W.; Gbenedio, Oghenekevwe M.; Vallon, Mario; Yuan, Jenny; de Haan, Sanne; Hemrika, Wieger; Rösch, Kathrin; Dang, Luke T.; Baker, David; Ott, Melanie; Depeille, Philippe; Wu, Sean M.; Drost, Jarno; Nusse, Roeland; Roose, Jeroen P.; Piehler, Jacob; Boj, Sylvia F.; Janda, Claudia Y.; Clevers, Hans; Kuo, Calvin J.; Garcia, K. Christopher

Structure of human frizzled5 by fiducial-assisted cryo-em supports a heterodimeric mechanism of canonical wnt signaling

eLife, v. 9, p. 1-20, article number e58464
Tsutsumi, Naotaka; Mukherjee, Somnath; Waghray, Deepa; Janda, Claudia Y.; Jude, Kevin M.; Miao, Yi; Burg, John S.; Aduri, Nanda Gowtham; Kossiakoff, Anthony A.; Gati, Cornelius; Garcia, K. Christopher

Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling

PLoS ONE, v. 15, (1), article number e0226928
Luca, Vincent C.; Miao, Yi; Li, Xingnan; Hollander, Michael J.; Kuo, Calvin J.; Christopher Garcia, K.

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Cell Stem Cell, v. 27, (1), p. 50-63.e5
Buikema, Jan W.; Lee, Soah; Goodyer, William R.; Maas, Renee G.; Chirikian, Orlando; Li, Guang; Miao, Yi; Paige, Sharon L.; Lee, Daniel; Wu, Haodi; Paik, David T.; Rhee, Siyeon; Tian, Lei; Galdos, Francisco X.; Puluca, Nazan; Beyersdorf, Benjamin; Hu, James; Beck, Aimee; Venkamatran, Sneha; Swami, Srilatha; Wijnker, Paul; Schuldt, Maike; Dorsch, Larissa M.; van Mil, Alain; Red-Horse, Kristy; Wu, Joy Y.; Geisen, Caroline; Hesse, Michael; Serpooshan, Vahid; Jovinge, Stefan; Fleischmann, Bernd K.; Doevendans, Pieter A.; van der Velden, Jolanda; Garcia, K. Christopher; Wu, Joseph C.; Sluijter, Joost P.G.; Wu, Sean M.

Article 3

RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer

JCI Insight, v. 4, (15), article number e127552
Gbenedio, Oghenekevwe M.; Bonnans, Caroline; Grun, Delphine; Wang, Chih Yang; Hatch, Ace J.; Mahoney, Michelle R.; Barras, David; Matli, Mary; Miao, Yi; Christopher Garcia, K.; Tejpar, Sabine; Delorenzi, Mauro; Venook, Alan P.; Nixon, Andrew B.; Warren, Robert S.; Roose, Jeroen P.; Depeille, Philippe

Receptor subtype discrimination using extensive shape complementary designed interfaces

Nature Structural and Molecular Biology, v. 26, (6), p. 407-414
Dang, Luke T.; Miao, Yi; Ha, Andrew; Yuki, Kanako; Park, Keunwan; Janda, Claudia Y.; Jude, Kevin M.; Mohan, Kritika; Ha, Nhi; Vallon, Mario; Yuan, Jenny; Vilches-Moure, José G.; Kuo, Calvin J.; Garcia, K. Christopher; Baker, David

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

Science, v. 364, (6442), article number eaav7532
Mohan, Kritika; Ueda, George; Kim, Ah Ram; Jude, Kevin M.; Fallas, Jorge A.; Guo, Yu; Hafer, Maximillian; Miao, Yi; Saxton, Robert A.; Piehler, Jacob; Sankaran, Vijay G.; Baker, David; Garcia, K. Christopher

Article 1

A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability

Cell Reports, v. 25, (2), p. 339-349.e9
Vallon, Mario; Yuki, Kanako; Nguyen, Thi D.; Chang, Junlei; Yuan, Jenny; Siepe, Dirk; Miao, Yi; Essler, Markus; Noda, Makoto; Garcia, K. Christopher; Kuo, Calvin J.

Article 2

Structural and In vivo studies on trehalose-6-phosphate synthase from pathogenic fungi provide insights into its catalytic mechanism, biological necessity, and potential for novel antifungal drug design

mBio, v. 8, (4), article number e00643-17
Miao, Yi; Tenor, Jennifer L.; Toffaletti, Dena L.; Maskarinec, Stacey A.; Liu, Jiuyu; Lee, Richard E.; Perfect, John R.; Brennan, Richard G.

Trehalose pathway as an antifungal target

Virulence, v. 8, (2), p. 143-149
Perfect, John R.; Tenor, Jennifer L.; Miao, Yi; Brennan, Richard G.

Article 1

Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (26), p. 7148-7153
Miaoa, Yi; Tenorb, Jennifer L.; Toffalettib, Dena L.; Washingtona, Erica J.; Liuc, Jiuyu; Shadrickc, William R.; Schumachera, Maria A.; Leec, Richard E.; Perfectb, John R.; Brennana, Richard G.

Article 1

Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China

Protein & Cell, v. 1, (5), p. 491-500
Wu, Yang; Lou, Zhiyong; Miao, Yi; Yu, Yue; Dong, Hui; Peng, Wei; Bartlam, Mark; Li, Xuemei; Rao, Zihe

2020 4

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Cell Stem Cell, v. 27, (5), p. 840-851.e6
Miao, Yi; Ha, Andrew; de Lau, Wim; Yuki, Kanako; Santos, António J.M.; You, Changjiang; Geurts, Maarten H.; Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Peng, Weng Chuan; Senlice, Ramazan; Piani, Carol; Buikema, Jan W.; Gbenedio, Oghenekevwe M.; Vallon, Mario; Yuan, Jenny; de Haan, Sanne; Hemrika, Wieger; Rösch, Kathrin; Dang, Luke T.; Baker, David; Ott, Melanie; Depeille, Philippe; Wu, Sean M.; Drost, Jarno; Nusse, Roeland; Roose, Jeroen P.; Piehler, Jacob; Boj, Sylvia F.; Janda, Claudia Y.; Clevers, Hans; Kuo, Calvin J.; Garcia, K. Christopher
Article

Structure of human frizzled5 by fiducial-assisted cryo-em supports a heterodimeric mechanism of canonical wnt signaling

eLife, v. 9, p. 1-20, article number e58464
Tsutsumi, Naotaka; Mukherjee, Somnath; Waghray, Deepa; Janda, Claudia Y.; Jude, Kevin M.; Miao, Yi; Burg, John S.; Aduri, Nanda Gowtham; Kossiakoff, Anthony A.; Gati, Cornelius; Garcia, K. Christopher
Article

Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling

PLoS ONE, v. 15, (1), article number e0226928
Luca, Vincent C.; Miao, Yi; Li, Xingnan; Hollander, Michael J.; Kuo, Calvin J.; Christopher Garcia, K.
Article

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Cell Stem Cell, v. 27, (1), p. 50-63.e5
Buikema, Jan W.; Lee, Soah; Goodyer, William R.; Maas, Renee G.; Chirikian, Orlando; Li, Guang; Miao, Yi; Paige, Sharon L.; Lee, Daniel; Wu, Haodi; Paik, David T.; Rhee, Siyeon; Tian, Lei; Galdos, Francisco X.; Puluca, Nazan; Beyersdorf, Benjamin; Hu, James; Beck, Aimee; Venkamatran, Sneha; Swami, Srilatha; Wijnker, Paul; Schuldt, Maike; Dorsch, Larissa M.; van Mil, Alain; Red-Horse, Kristy; Wu, Joy Y.; Geisen, Caroline; Hesse, Michael; Serpooshan, Vahid; Jovinge, Stefan; Fleischmann, Bernd K.; Doevendans, Pieter A.; van der Velden, Jolanda; Garcia, K. Christopher; Wu, Joseph C.; Sluijter, Joost P.G.; Wu, Sean M.
Article

2019 3

RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer

JCI Insight, v. 4, (15), article number e127552
Gbenedio, Oghenekevwe M.; Bonnans, Caroline; Grun, Delphine; Wang, Chih Yang; Hatch, Ace J.; Mahoney, Michelle R.; Barras, David; Matli, Mary; Miao, Yi; Christopher Garcia, K.; Tejpar, Sabine; Delorenzi, Mauro; Venook, Alan P.; Nixon, Andrew B.; Warren, Robert S.; Roose, Jeroen P.; Depeille, Philippe
Article

Receptor subtype discrimination using extensive shape complementary designed interfaces

Nature Structural and Molecular Biology, v. 26, (6), p. 407-414
Dang, Luke T.; Miao, Yi; Ha, Andrew; Yuki, Kanako; Park, Keunwan; Janda, Claudia Y.; Jude, Kevin M.; Mohan, Kritika; Ha, Nhi; Vallon, Mario; Yuan, Jenny; Vilches-Moure, José G.; Kuo, Calvin J.; Garcia, K. Christopher; Baker, David
Article

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

Science, v. 364, (6442), article number eaav7532
Mohan, Kritika; Ueda, George; Kim, Ah Ram; Jude, Kevin M.; Fallas, Jorge A.; Guo, Yu; Hafer, Maximillian; Miao, Yi; Saxton, Robert A.; Piehler, Jacob; Sankaran, Vijay G.; Baker, David; Garcia, K. Christopher
Article

2018 1

A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability

Cell Reports, v. 25, (2), p. 339-349.e9
Vallon, Mario; Yuki, Kanako; Nguyen, Thi D.; Chang, Junlei; Yuan, Jenny; Siepe, Dirk; Miao, Yi; Essler, Markus; Noda, Makoto; Garcia, K. Christopher; Kuo, Calvin J.
Article

2017 2

Structural and In vivo studies on trehalose-6-phosphate synthase from pathogenic fungi provide insights into its catalytic mechanism, biological necessity, and potential for novel antifungal drug design

mBio, v. 8, (4), article number e00643-17
Miao, Yi; Tenor, Jennifer L.; Toffaletti, Dena L.; Maskarinec, Stacey A.; Liu, Jiuyu; Lee, Richard E.; Perfect, John R.; Brennan, Richard G.
Article

Trehalose pathway as an antifungal target

Virulence, v. 8, (2), p. 143-149
Perfect, John R.; Tenor, Jennifer L.; Miao, Yi; Brennan, Richard G.
Article

2016 1

Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (26), p. 7148-7153
Miaoa, Yi; Tenorb, Jennifer L.; Toffalettib, Dena L.; Washingtona, Erica J.; Liuc, Jiuyu; Shadrickc, William R.; Schumachera, Maria A.; Leec, Richard E.; Perfectb, John R.; Brennana, Richard G.
Article

2010 1

Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China

Protein & Cell, v. 1, (5), p. 491-500
Wu, Yang; Lou, Zhiyong; Miao, Yi; Yu, Yue; Dong, Hui; Peng, Wei; Bartlam, Mark; Li, Xuemei; Rao, Zihe
Article

Teaching Assignment

2026-27 Fall 1 2025-26 Summer 1 2025-26 Spring 4 2025-26 Winter 0 2025-26 Fall 3 2024-25 Summer 0

LIFS6114J

Current Topics in Biotechnology and Traditional Chinese Medicine

UROP1100S

Undergraduate Research Opportunities Series 1

LIFS2220	Biochemistry II
LIFS4963	Biotechnology Capstone Project
LIFS6111X	Life Science Postgraduate Student Seminar
SCIE1500	Guided Study on Research I

LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4963	Biotechnology Capstone Project
LIFS6114I	Current Topics in Biotechnology and Traditional Chinese Medicine

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2023 to December 2026 (As of 27 October 2026)

Current RPGs

Master of Philosophy

LI, Yajin
Life Science
MU, Wenyu
Life Science
WANG, Ying
Life Science
WONG, Tsz Lok
Life Science

Projects

From January 2024 to December 2026

All Projects 1

No Projects.
Structural and Mechanistic Insights into Adhesion GPCR GPR125

黏附GPCR GPR125的結構與機制研究 Leading

RGC - Early Career Scheme
Project Team (HKUST)
MIAO Yi (Lead)
2026 -

Research Interest

Publications

2026 3

2025 3

2024 1

2023 1

2022 4

2021 1

2020 4

2019 3

2018 1

2017 2

2016 1

2010 1

Article 3

Article 3

Article 1

Article 1

Article 4

Article 1

Article 4

Article 3

Article 1

Article 2

Article 1

Article 1

2020 4

2019 3

2018 1

2017 2

2016 1

2010 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2023 to December 2026 (As of 27 October 2026)

Current RPGs

Projects

From January 2024 to December 2026

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