Faculty Profiles - LIAO Yi | The Hong Kong University of Science and Technology

Yi LIAO
廖毅

PhD in Chemistry
University of Michigan, 2015

Assistant Professor
Division of Life Science

(852) 2358 7922
liaoy@ust.hk
Room 5471
Personal Web

ORCID

0000-0002-0414-439X

Scopus ID

57204864329

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Microbiology
Quantitative biology
Systems biology
Single particle / molecule / cell studies

Publications

All Years 10 2025 0 2024 1 2023 0 2022 0 2021 1 2020 1 2019 7

2024 1

Emerging tools for uncovering genetic and transcriptomic heterogeneities in bacteria

Biophysical Reviews, v. 16, (1), p. 109-124
Liao, Yi
Article

2021 1

The circadian clock ensures successful DNA replication in cyanobacteria

Proceedings of the National Academy of Sciences of the United States of America, v. 118, (20), article number e2022516118
Liao, Yi; Rust, Michael J.
Article

2020 1

Daily Cycles of Reversible Protein Condensation in Cyanobacteria

Cell Reports, v. 32, (7), article number 108032
Pattanayak, Gopal K.; Liao, Yi; Wallace, Edward W.J.; Budnik, Bogdan; Drummond, D. Allan; Rust, Michael J.
Article

2019 1

Synthesis of site-specific crown ether adducts to DNA abasic sites: 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine and 2′-Deoxycytidine

Methods in Molecular Biology / Humana Press Inc., 2019, p. 15-25
An, Na; Fleming, Aaron M.; Rosecrans, Nicole C.; Liao, Yi; Burrows, Cynthia J.
Book chapter

2018 1

The Min Oscillator Defines Sites of Asymmetric Cell Division in Cyanobacteria during Stress Recovery

Cell Systems, v. 7, (5), p. 471-481.e6
Liao, Yi; Rust, Michael J.
Article

2017 1

Resolution Optimization Based on Fluorophore Photophysics in Single-Molecule Localization Microscopy

Biophysical Journal, v. 113, (9), p. 1907-1908
Liao, Yi
Article

2016 1

Single-Molecule DNA Polymerase Dynamics at a Bacterial Replisome in Live Cells

Biophysical Journal, v. 111, (12), p. 2562-2569
Liao, Yi; Li, Yilai; Schroeder, Jeremy W.; Simmons, Lyle A.; Biteen, Julie S.
Article

2015 1

Single-molecule motions and interactions in live cells reveal target search dynamics in mismatch repair

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (50), p. E6898-E6906
Liao, Yi; Schroeder, Jeremy W.; Gao, Burke; Simmons, Lyle A.; Biteen, Julie S.
Article

2012 1

Heterogeneous single-molecule diffusion in one-, two-, and three-dimensional microporous coordination polymers: Directional, trapped, and immobile guests

Nano Letters, v. 12, (6), p. 3080-3085
Liao, Yi; Yang, Seong K.; Koh, Kyoungmoo; Matzger, Adam J.; Biteen, Julie S.
Article

2011 1

Copper/H₂O₂-Mediated oxidation of 2′-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts

Journal of Organic Chemistry, v. 76, (19), p. 7953-7963
Fleming, Aaron M.; Kannan, Arunkumar; Muller, James G.; Liao, Yi; Burrows, Cynthia J.
Article

Article 1

Emerging tools for uncovering genetic and transcriptomic heterogeneities in bacteria

Biophysical Reviews, v. 16, (1), p. 109-124
Liao, Yi

Article 1

The circadian clock ensures successful DNA replication in cyanobacteria

Proceedings of the National Academy of Sciences of the United States of America, v. 118, (20), article number e2022516118
Liao, Yi; Rust, Michael J.

Article 1

Daily Cycles of Reversible Protein Condensation in Cyanobacteria

Cell Reports, v. 32, (7), article number 108032
Pattanayak, Gopal K.; Liao, Yi; Wallace, Edward W.J.; Budnik, Bogdan; Drummond, D. Allan; Rust, Michael J.

Book chapter 1

Synthesis of site-specific crown ether adducts to DNA abasic sites: 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine and 2′-Deoxycytidine

Methods in Molecular Biology / Humana Press Inc., 2019, p. 15-25
An, Na; Fleming, Aaron M.; Rosecrans, Nicole C.; Liao, Yi; Burrows, Cynthia J.

Article 1

The Min Oscillator Defines Sites of Asymmetric Cell Division in Cyanobacteria during Stress Recovery

Cell Systems, v. 7, (5), p. 471-481.e6
Liao, Yi; Rust, Michael J.

Article 1

Resolution Optimization Based on Fluorophore Photophysics in Single-Molecule Localization Microscopy

Biophysical Journal, v. 113, (9), p. 1907-1908
Liao, Yi

Article 1

Single-Molecule DNA Polymerase Dynamics at a Bacterial Replisome in Live Cells

Biophysical Journal, v. 111, (12), p. 2562-2569
Liao, Yi; Li, Yilai; Schroeder, Jeremy W.; Simmons, Lyle A.; Biteen, Julie S.

Article 1

Single-molecule motions and interactions in live cells reveal target search dynamics in mismatch repair

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (50), p. E6898-E6906
Liao, Yi; Schroeder, Jeremy W.; Gao, Burke; Simmons, Lyle A.; Biteen, Julie S.

Article 1

Heterogeneous single-molecule diffusion in one-, two-, and three-dimensional microporous coordination polymers: Directional, trapped, and immobile guests

Nano Letters, v. 12, (6), p. 3080-3085
Liao, Yi; Yang, Seong K.; Koh, Kyoungmoo; Matzger, Adam J.; Biteen, Julie S.

Article 1

Copper/H₂O₂-Mediated oxidation of 2′-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts

Journal of Organic Chemistry, v. 76, (19), p. 7953-7963
Fleming, Aaron M.; Kannan, Arunkumar; Muller, James G.; Liao, Yi; Burrows, Cynthia J.

2019 1

Synthesis of site-specific crown ether adducts to DNA abasic sites: 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine and 2′-Deoxycytidine

Methods in Molecular Biology / Humana Press Inc., 2019, p. 15-25
An, Na; Fleming, Aaron M.; Rosecrans, Nicole C.; Liao, Yi; Burrows, Cynthia J.
Book chapter

2018 1

The Min Oscillator Defines Sites of Asymmetric Cell Division in Cyanobacteria during Stress Recovery

Cell Systems, v. 7, (5), p. 471-481.e6
Liao, Yi; Rust, Michael J.
Article

2017 1

Resolution Optimization Based on Fluorophore Photophysics in Single-Molecule Localization Microscopy

Biophysical Journal, v. 113, (9), p. 1907-1908
Liao, Yi
Article

2016 1

Single-Molecule DNA Polymerase Dynamics at a Bacterial Replisome in Live Cells

Biophysical Journal, v. 111, (12), p. 2562-2569
Liao, Yi; Li, Yilai; Schroeder, Jeremy W.; Simmons, Lyle A.; Biteen, Julie S.
Article

2015 1

Single-molecule motions and interactions in live cells reveal target search dynamics in mismatch repair

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (50), p. E6898-E6906
Liao, Yi; Schroeder, Jeremy W.; Gao, Burke; Simmons, Lyle A.; Biteen, Julie S.
Article

2012 1

Heterogeneous single-molecule diffusion in one-, two-, and three-dimensional microporous coordination polymers: Directional, trapped, and immobile guests

Nano Letters, v. 12, (6), p. 3080-3085
Liao, Yi; Yang, Seong K.; Koh, Kyoungmoo; Matzger, Adam J.; Biteen, Julie S.
Article

2011 1

Copper/H₂O₂-Mediated oxidation of 2′-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts

Journal of Organic Chemistry, v. 76, (19), p. 7953-7963
Fleming, Aaron M.; Kannan, Arunkumar; Muller, James G.; Liao, Yi; Burrows, Cynthia J.
Article

No Publications

Teaching Assignment

2025-26 Fall 1 2024-25 Summer 1 2024-25 Spring 2 2024-25 Winter 0 2024-25 Fall 6 2023-24 Summer 1

LIFS5710

Cellular Regulation

UROP2100P

Undergraduate Research Opportunities Series 2

LIFS3060	Microbiology
UROP1100O	Undergraduate Research Opportunities Series 1

DASC3230	Statistical Modeling and Machine Learning
LIFS4910A	Independent Study
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS5710	Cellular Regulation
LIFS6113H	Current Topics in Biochemistry and Biophysics
LIFS6170	Special Topics in Molecular, Cell and Developmental Biology

SISP1114

Mathematical Wonders in Biology

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 19 December 2025)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

CAI, Yanqing
Life Science
HONG, Cheung
Life Science

Master of Philosophy

ZHANG, Wenjie
Life Science
THEN, Claudia Regina
Life Science

Graduated RPGs

Master of Philosophy

CAI, Yanqing
Life Science( Completed in 2025 )
HONG, Cheung
Life Science( Completed in 2025 )

Projects

From January 2023 to December 2025

All Projects 2

No Projects.
Generalizing Covariance Spectrum Theory for Mechanistic Insights into Neural Population Activity

面向神經元群體活動機制的協方差頻譜理論拓展 Leading

RGC - General Research Fund
Project Team (HKUST)
LIAO Yi (Lead)

HU Yu
2025 -
Bacterial Cell-Fate Transitions under Dynamically Changing Environments

動態環境變化下的細菌細胞命運調控 Leading

RGC - Early Career Scheme
Project Team (HKUST)
LIAO Yi (Lead)
2025 -

Research Interest

Publications

2024 1

2021 1

2020 1

2019 1

2018 1

2017 1

2016 1

2015 1

2012 1

2011 1

Article 1

Article 1

Article 1

Book chapter 1

Article 1

Article 1

Article 1

Article 1

Article 1

Article 1

2019 1

2018 1

2017 1

2016 1

2015 1

2012 1

2011 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 19 December 2025)

Current RPGs

Graduated RPGs

Projects

From January 2023 to December 2025

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