Faculty Profiles - LEUNG Yat Hin Nicki | The Hong Kong University of Science and Technology

Yat Hin Nicki LEUNG
梁逸軒

PhD in Biology
The Chinese University of Hong Kong, 2015

Lecturer I
Division of Life Science

(852) 2358 8153
nickileung@ust.hk
Room 5450

Google Scholar

1ZrdUGcAAAAJ

ORCID

0000-0001-6836-6445

ResearcherID

GRG-6787-2022

Scopus ID

55515985900

Research Interest Publications Teaching Assignment

Research Interest

Immunology
Allergy
Cancer

Publications

All Years 34 2026 0 2025 4 2024 2 2023 1 2022 3 2021 1 2020 23

2025 4

Fish Allergenicity Ladder and Parvalbumin Epitopes for Predicting Clinical Cross-Reactivity and Reintroduction in Chinese Population

Allergy: European Journal of Allergy and Clinical Immunology, v. 80, (10), p. 2810-2823
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Agnes S.Y.; Tang, Man Fung; Marknell DeWitt, Åsa; Rosa Duque, Jaime S.; Chua, Gilbert T.; Yau, Yat Sun; Chan, Wai Hung; Ho, Po Ki; Kwan, Mike Y.W.; Lee, Qun Ui; Wong, Joshua S.C.; Lam, Ivan C.S.; Cheng, James W.C.H.; Luk, David C.K.; Liu, Zhongyi; Ngai, Noelle Anne; Chan, Oi Man; Leung, Patrick S.C.; Wong, Gary W.K.; Leung, Ting Fan
Article

Next-Generation Allergen-Specific Immunotherapy for Food Allergy

Clinical Reviews in Allergy and Immunology, v. 68, (1), article number 93
Lee, Joyce Z.X.; Sit, Jason K.C.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.; Leung, Ting Fan; Wai, Christine Y.Y.
Article

Revealing the Diverse Allergenic Protein Repertoire of Six Widely Consumed Crab Species: A Species-Specific Allergen in King Crab

Allergy: European Journal of Allergy and Clinical Immunology
Li, Shanshan; Bian, Jingyuan; Xiong, Qing; Wong, Brian Shing Hei; Tsui, Stephen Kwok Wing; Kwan, Kin Ming; Leung, Nicki Yat Hin; Leung, Ting Fan; Leung, Patrick S.C.; Chu, Ka Hou; Xiao, Xiaojun; Wai, Christine Yee Yan
Article

Shellfish Allergy Immunotherapy: Are We Moving Forward?

Allergies, v. 5, (4), article number 44
Fung, Lucio H.T.; Yeung, Ho Lam; Lim, Chun Wai; Jiang, Shan; Leung, Nicki Y.H.; Leung, Patrick S.C.; Leung, Ting Fan; Wai, Christine Y.Y.
Article

2024 2

Real-World Sensitization and Tolerance Pattern to Seafood in Fish-Allergic Individuals

Journal of Allergy and Clinical Immunology: In Practice, v. 12, (3), p. 633-642.e9
Leung, Agnes S.Y.; Wai, Christine Y.Y.; Leung, Nicki Y.H.; Ngai, Noelle Anne; Chua, Gilbert T.; Ho, Po Ki; Lam, Ivan C.S.; Cheng, James W.C.H.; Chan, Oi Man; Li, Pui Fung; Au, Ann W.S.; Leung, Chloris H.W.; Cheng, Nam Sze; Tang, Man Fung; Fong, Brian L.Y.; Rosa Duque, Jaime S.; Wong, Joshua S.C.; Luk, David C.K.; Ho, Marco H.K.; Kwan, Mike Y.W.; Yau, Yat Sun; Lee, Qun Ui; Chan, Wai Hung; Wong, Gary W.K.; Leung, Ting Fan
Article

Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy

Clinical Reviews in Allergy and Immunology, v. 66, (2), p. 250-259
Tong, Wai Sze; Li, Shanshan; Leung, Nicki Y.H.; Wong, Wing Tak; Leung, Ting Fan; Leung, Patrick S.C.; Chu, Ka Hou; Wai, Christine Y.Y.
Article

2023 1

Differential patterns of fish sensitization in Asian populations: Implication for precision diagnosis

Allergology International, v. 72, (3), p. 458-465
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Agnes S.Y.; Fusayasu, Naoko; Sato, Sakura; Xu, Kary J.Y.; Yau, Yat Sun; Rosa Duque, Jaime S.; Kwan, Mike Y.W.; Cheng, James W.C.H.; Chan, Wai Hung; Chua, Gilbert T.; Lee, Qun Ui; Luk, David C.K.; Ho, Po Ki; Wong, Joshua S.C.; Lam, Ivan C.S.; Wong, Gary W.K.; Ebisawa, Motohiro; Leung, Ting Fan
Article

2022 3

Comprehending the allergen repertoire of shrimp for precision molecular diagnosis of shrimp allergy

Allergy: European Journal of Allergy and Clinical Immunology, v. 77, (10), p. 3041-3051
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Agnes S.Y.; Ngai, Sai Ming; Pacharn, Punchama; Yau, Yat Sun; Rosa Duque, Jaime Sou Da; Kwan, Mike Y W; Jirapongsananuruk, Orathai; Chan, Wai Hung; Chua, Gilbert T; Lee, Qun Ui; Piboonpocanun, Surapon; Ho, Po Ki; Wong, Joshua S C.; Li, Shanshan; Xu, Kary J.Y.; Wong, Gary W.K.; Chu, Ka Hou; Leung, Patrick S.C.; Vichyanond, Pakit; Leung, Ting Fan
Article

Identification of Potentially Tolerated Fish Species by Multiplex IgE Testing of a Multinational Fish-Allergic Patient Cohort

Journal of Allergy and Clinical Immunology: In Practice, v. 10, (12), p. 3284-3292
Kalic, Tanja; Kuehn, Annette; Aumayr, Martina; Bartra, Joan; Bindslev-Jensen, Carsten; Codreanu-Morel, Françoise; Domínguez, Olga; Forstenlechner, Peter; Hemmer, Wolfgang; Kamath, Sandip D.; Leung, Agnes; Leung, Nicki; Lifanov, Yuri; Mortz, Charlotte G.; Pascal, Mariona; Ristl, Robin; Sørensen, Martin; Üzülmez, Öykü; Yeghiazaryan, Lusine; Wong, Gary; Hafner, Christine; Breiteneder, Heimo
Article

Developments and emerging technologies in allergic and immunologic disease management

Allergic and Immunologic Diseases / Elsevier, 2022, p. 187-219
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Shao, Tihong; Chu, Ka Hou; Leung, Patrick S.C.
Book chapter

2021 1

Cell-Based Functional IgE Assays Are Superior to Conventional Allergy Tests for Shrimp Allergy Diagnosis

Journal of Allergy and Clinical Immunology: In Practice, v. 9, (1), p. 236-244.e9
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Agnes S.Y.; Shum, Yuki; Leung, Patrick S.C.; Chu, Ka Hou; Kwan, Yat Wah; Lee, Qun Ui; Wong, Joshua S.C.; Lam, Ivan C.S.; Li, Pui Fung; Xu, Kary J.Y.; Lam, Cheuk Yin; Sun, Jinlyu; Wong, Gary W.K.; Leung, Ting Fan
Article

2020 4

Characteristics of Chinese fish-allergic patients: Findings from double-blind placebo-controlled food challenges

Journal of Allergy and Clinical Immunology: In Practice, v. 8, (6), p. 2098-2100.e8
Leung, Agnes Sze Yin; Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Xu, Kary Jia Ying; Lam, Maco Cheuk Yin; Shum, Yuki Yuk; Lee, Tak Hong; Ho, Marco Hok Kung; Sou Da Rosa Duque, Jaime; Chua, Gilbert T.; Yau, Yat Sun; Chan, Wai Hung; Ho, Po Ki; Wong, Gary Wing Kin; Leung, Ting Fan
Article

Molecular and immunological characterization of grass carp (Ctenopharyngodon idella) parvalbumin Cten i 1: A major fish allergen in Hong Kong

Pediatric Allergy and Immunology, v. 31, (7), p. 792-804
Leung, Nicki Yat Hin; Leung, Agnes Sze Yin; Xu, Kary Jia Ying; Wai, Christine Yee Yan; Lam, Cheuk Yin; Wong, Gary Wing Kin; Leung, Ting Fan
Article

Overcoming shellfish allergy: How far have we come?

International journal of molecular sciences, v. 21, (6), article number 2234
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.; Leung, Agnes S.Y.; Wong, Gary W.K.; Leung, Ting Fan
Article

T-Cell Epitope Immunotherapy in Mouse Models of Food Allergy

Methods in Molecular Biology / Humana Press Inc., 2020, p. 337-355
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.
Book chapter

2019 6

Allergen immunotherapy for food allergy from the Asian perspective: key challenges and opportunities

Expert Review of Clinical Immunology, v. 15, (2), p. 153-164
Leung, Agnes Sze Yin; Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Leung, Ting Fan; Wong, Gary Wing Kin
Article

Immunotherapy of Food Allergy: a Comprehensive Review

Clinical Reviews in Allergy and Immunology, v. 57, (1), p. 55-73
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Patrick S.C.; Chu, Ka Hou
Article

Mimotope-based allergen-specific immunotherapy: ready for prime time?

Cellular and Molecular Immunology, v. 16, (11), p. 890-891
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Chu, Ka Hou; Leung, Patrick S.C.
Article

Modulating shrimp tropomyosin-mediated allergy: Hypoallergen DNA vaccines induce regulatory T cells to reduce hypersensitivity in mouse model

International journal of molecular sciences, v. 20, (18), article number 4656
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Patrick S.C.; Chu, Ka Hou
Article

Component-resolved Diagnosis of IgE-mediated Fish Allergy with Grass Carp Allergens

LEUNG, Yat Hin Nicki; Wai, Christine Y.Y.; Leung, Agnes Sze Yin; Wong MD , Gary WK.; Leung MD FRCPCH FAAAAI, Ting Fan
Conference paper

Differential IgE binding to freshwater and seawater fishes in a Chinese population offish allergic subjects

Paper presented at Abstracts from the European Academy of Allergy and Clinical Immunology Congress, Lisbon, Portugal, p. 471
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wai, Christine Yee Yan; Xu, Kary J.Y.; Lam, Maco Cheuk Yin; Wong, G. W.K.; Leung, T. F.
Conference paper

2018 1

Diagnosis of fish and shellfish allergies

Journal of Asthma and Allergy, v. 11, p. 247-260
Tong, Wai Sze; Yuen, Agatha W.T.; Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.
Article

2017 5

Low-Dose Allergen-Specific Immunotherapy Induces Tolerance in a Murine Model of Shrimp Allergy

International Archives of Allergy and Immunology, v. 174, (2), p. 86-96
Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Shu, Shang An; Chang, Christopher C.; Chu, Ka Hou; Leung, Patrick S.C.
Article

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries

Cellular and Molecular Immunology, v. 14, (3), p. 308-318
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Ho, Marco H.K.; Liu, Ruiwu; Lam, Kit S.; Wang, Jin Jun; Shu, Shang An; Chu, Ka Hou; Leung, Patrick S.C.
Article

Advances in seafood allergy research: Allergen detection and allergen-specific immunotherapy

Food Allergy / CRC Press, 2017, p. 80-105
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Chu, Ka Hou; Leung, Patrick S.C.
Book chapter

Clinical value of component-resolved diagnosis in fish allergy

Paper presented at Korean Academy of Allergy and Clinical Immunology Congress, Seoul, Korea, Republic of
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wong, G. W.K.; Leung, T. F.
Conference paper

Is testing for different allergen components useful in diagnosing IgE-mediated allergy to freshwater and seawater fishes?

Paper presented at European Academy of Allergy and Clinical Immunology Congress, Helsinki, Finland, p. 185
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wong, G. W.K.; Leung , T
Conference paper

2016 2

T cell epitope immunotherapy ameliorates allergic responses in a murine model of shrimp allergy

Clinical and Experimental Allergy, v. 46, (3), p. 491-503
Wai, C. Y.Y.; Leung, N. Y.H.; Leung, P. S.C.; Chu, K. H.
Article

Mimotopes of the major shellfish allergen tropomyosin suppress splenocyte proliferation and local cytokine expression in a mouse model of shellfish allergy

LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Leung, Patrick S.C.; Chu, Ka Hou
Conference paper

2015 1

Screening of OBOC peptide libraries with polyclonal IgE identifies mimotopes corresponding to immunodominant regions of the major shrimp allergen tropomyosin

Paper presented at The 2015 Hong Kong Inter-University Postgraduate Symposium in Life Sciences, , Hong Kong
LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Leung, Patrick S.C.; Chu, Ka Hou
Conference paper

2014 3

Current immunological and molecular biological perspectives on seafood allergy: A comprehensive review

Clinical Reviews in Allergy and Immunology, v. 46, (3), p. 180-197
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Shu, Shangan; Wang, Jinjun; Kenny, Thomas P.; Chu, Ka Hou; Leung, Patrick S.C.
Article

Immunization with hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity

PLoS ONE, v. 9, (11), article number e111649
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Ho, Marco H.K.; Gershwin, Laurel J.; Shu, Shang An; Leung, Patrick S.C.; Chu, Ka Hou
Article

High throughput screening of mimotopes using OBOC combinatorial peptide library: in silico and in vitro validation of mimicry potential and speciﬁcity for allergy treatment

LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Ho, Marco H.K.; Lam, K.; Leung, Patrick S.C.; Chu, Ka Hou
Conference paper

2012 1

From Molecular Studies of Allergens to Development of Immunotherapy of Allergies

Journal of Allergy & Therapy, v. 3, (3), article number 1000124
Wai, Christine Y.Y.; LEUNG, Yat Hin Nicki; Chu, Ka Hou; Leung, Patrick S.C.
Article

Article 4

Fish Allergenicity Ladder and Parvalbumin Epitopes for Predicting Clinical Cross-Reactivity and Reintroduction in Chinese Population

Allergy: European Journal of Allergy and Clinical Immunology, v. 80, (10), p. 2810-2823
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Agnes S.Y.; Tang, Man Fung; Marknell DeWitt, Åsa; Rosa Duque, Jaime S.; Chua, Gilbert T.; Yau, Yat Sun; Chan, Wai Hung; Ho, Po Ki; Kwan, Mike Y.W.; Lee, Qun Ui; Wong, Joshua S.C.; Lam, Ivan C.S.; Cheng, James W.C.H.; Luk, David C.K.; Liu, Zhongyi; Ngai, Noelle Anne; Chan, Oi Man; Leung, Patrick S.C.; Wong, Gary W.K.; Leung, Ting Fan

Next-Generation Allergen-Specific Immunotherapy for Food Allergy

Clinical Reviews in Allergy and Immunology, v. 68, (1), article number 93
Lee, Joyce Z.X.; Sit, Jason K.C.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.; Leung, Ting Fan; Wai, Christine Y.Y.

Revealing the Diverse Allergenic Protein Repertoire of Six Widely Consumed Crab Species: A Species-Specific Allergen in King Crab

Allergy: European Journal of Allergy and Clinical Immunology
Li, Shanshan; Bian, Jingyuan; Xiong, Qing; Wong, Brian Shing Hei; Tsui, Stephen Kwok Wing; Kwan, Kin Ming; Leung, Nicki Yat Hin; Leung, Ting Fan; Leung, Patrick S.C.; Chu, Ka Hou; Xiao, Xiaojun; Wai, Christine Yee Yan

Shellfish Allergy Immunotherapy: Are We Moving Forward?

Allergies, v. 5, (4), article number 44
Fung, Lucio H.T.; Yeung, Ho Lam; Lim, Chun Wai; Jiang, Shan; Leung, Nicki Y.H.; Leung, Patrick S.C.; Leung, Ting Fan; Wai, Christine Y.Y.

Article 2

Real-World Sensitization and Tolerance Pattern to Seafood in Fish-Allergic Individuals

Journal of Allergy and Clinical Immunology: In Practice, v. 12, (3), p. 633-642.e9
Leung, Agnes S.Y.; Wai, Christine Y.Y.; Leung, Nicki Y.H.; Ngai, Noelle Anne; Chua, Gilbert T.; Ho, Po Ki; Lam, Ivan C.S.; Cheng, James W.C.H.; Chan, Oi Man; Li, Pui Fung; Au, Ann W.S.; Leung, Chloris H.W.; Cheng, Nam Sze; Tang, Man Fung; Fong, Brian L.Y.; Rosa Duque, Jaime S.; Wong, Joshua S.C.; Luk, David C.K.; Ho, Marco H.K.; Kwan, Mike Y.W.; Yau, Yat Sun; Lee, Qun Ui; Chan, Wai Hung; Wong, Gary W.K.; Leung, Ting Fan

Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy

Clinical Reviews in Allergy and Immunology, v. 66, (2), p. 250-259
Tong, Wai Sze; Li, Shanshan; Leung, Nicki Y.H.; Wong, Wing Tak; Leung, Ting Fan; Leung, Patrick S.C.; Chu, Ka Hou; Wai, Christine Y.Y.

Article 1

Differential patterns of fish sensitization in Asian populations: Implication for precision diagnosis

Allergology International, v. 72, (3), p. 458-465
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Agnes S.Y.; Fusayasu, Naoko; Sato, Sakura; Xu, Kary J.Y.; Yau, Yat Sun; Rosa Duque, Jaime S.; Kwan, Mike Y.W.; Cheng, James W.C.H.; Chan, Wai Hung; Chua, Gilbert T.; Lee, Qun Ui; Luk, David C.K.; Ho, Po Ki; Wong, Joshua S.C.; Lam, Ivan C.S.; Wong, Gary W.K.; Ebisawa, Motohiro; Leung, Ting Fan

Article 2

Comprehending the allergen repertoire of shrimp for precision molecular diagnosis of shrimp allergy

Allergy: European Journal of Allergy and Clinical Immunology, v. 77, (10), p. 3041-3051
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Agnes S.Y.; Ngai, Sai Ming; Pacharn, Punchama; Yau, Yat Sun; Rosa Duque, Jaime Sou Da; Kwan, Mike Y W; Jirapongsananuruk, Orathai; Chan, Wai Hung; Chua, Gilbert T; Lee, Qun Ui; Piboonpocanun, Surapon; Ho, Po Ki; Wong, Joshua S C.; Li, Shanshan; Xu, Kary J.Y.; Wong, Gary W.K.; Chu, Ka Hou; Leung, Patrick S.C.; Vichyanond, Pakit; Leung, Ting Fan

Identification of Potentially Tolerated Fish Species by Multiplex IgE Testing of a Multinational Fish-Allergic Patient Cohort

Journal of Allergy and Clinical Immunology: In Practice, v. 10, (12), p. 3284-3292
Kalic, Tanja; Kuehn, Annette; Aumayr, Martina; Bartra, Joan; Bindslev-Jensen, Carsten; Codreanu-Morel, Françoise; Domínguez, Olga; Forstenlechner, Peter; Hemmer, Wolfgang; Kamath, Sandip D.; Leung, Agnes; Leung, Nicki; Lifanov, Yuri; Mortz, Charlotte G.; Pascal, Mariona; Ristl, Robin; Sørensen, Martin; Üzülmez, Öykü; Yeghiazaryan, Lusine; Wong, Gary; Hafner, Christine; Breiteneder, Heimo

Book chapter 1

Developments and emerging technologies in allergic and immunologic disease management

Allergic and Immunologic Diseases / Elsevier, 2022, p. 187-219
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Shao, Tihong; Chu, Ka Hou; Leung, Patrick S.C.

Article 1

Cell-Based Functional IgE Assays Are Superior to Conventional Allergy Tests for Shrimp Allergy Diagnosis

Journal of Allergy and Clinical Immunology: In Practice, v. 9, (1), p. 236-244.e9
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Agnes S.Y.; Shum, Yuki; Leung, Patrick S.C.; Chu, Ka Hou; Kwan, Yat Wah; Lee, Qun Ui; Wong, Joshua S.C.; Lam, Ivan C.S.; Li, Pui Fung; Xu, Kary J.Y.; Lam, Cheuk Yin; Sun, Jinlyu; Wong, Gary W.K.; Leung, Ting Fan

Article 3

Characteristics of Chinese fish-allergic patients: Findings from double-blind placebo-controlled food challenges

Journal of Allergy and Clinical Immunology: In Practice, v. 8, (6), p. 2098-2100.e8
Leung, Agnes Sze Yin; Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Xu, Kary Jia Ying; Lam, Maco Cheuk Yin; Shum, Yuki Yuk; Lee, Tak Hong; Ho, Marco Hok Kung; Sou Da Rosa Duque, Jaime; Chua, Gilbert T.; Yau, Yat Sun; Chan, Wai Hung; Ho, Po Ki; Wong, Gary Wing Kin; Leung, Ting Fan

Molecular and immunological characterization of grass carp (Ctenopharyngodon idella) parvalbumin Cten i 1: A major fish allergen in Hong Kong

Pediatric Allergy and Immunology, v. 31, (7), p. 792-804
Leung, Nicki Yat Hin; Leung, Agnes Sze Yin; Xu, Kary Jia Ying; Wai, Christine Yee Yan; Lam, Cheuk Yin; Wong, Gary Wing Kin; Leung, Ting Fan

Overcoming shellfish allergy: How far have we come?

International journal of molecular sciences, v. 21, (6), article number 2234
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.; Leung, Agnes S.Y.; Wong, Gary W.K.; Leung, Ting Fan

Book chapter 1

T-Cell Epitope Immunotherapy in Mouse Models of Food Allergy

Methods in Molecular Biology / Humana Press Inc., 2020, p. 337-355
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.

Article 4

Allergen immunotherapy for food allergy from the Asian perspective: key challenges and opportunities

Expert Review of Clinical Immunology, v. 15, (2), p. 153-164
Leung, Agnes Sze Yin; Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Leung, Ting Fan; Wong, Gary Wing Kin

Immunotherapy of Food Allergy: a Comprehensive Review

Clinical Reviews in Allergy and Immunology, v. 57, (1), p. 55-73
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Patrick S.C.; Chu, Ka Hou

Mimotope-based allergen-specific immunotherapy: ready for prime time?

Cellular and Molecular Immunology, v. 16, (11), p. 890-891
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Chu, Ka Hou; Leung, Patrick S.C.

Modulating shrimp tropomyosin-mediated allergy: Hypoallergen DNA vaccines induce regulatory T cells to reduce hypersensitivity in mouse model

International journal of molecular sciences, v. 20, (18), article number 4656
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Patrick S.C.; Chu, Ka Hou

Conference paper 2

Component-resolved Diagnosis of IgE-mediated Fish Allergy with Grass Carp Allergens

LEUNG, Yat Hin Nicki; Wai, Christine Y.Y.; Leung, Agnes Sze Yin; Wong MD , Gary WK.; Leung MD FRCPCH FAAAAI, Ting Fan

Differential IgE binding to freshwater and seawater fishes in a Chinese population offish allergic subjects

Paper presented at Abstracts from the European Academy of Allergy and Clinical Immunology Congress, Lisbon, Portugal, p. 471
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wai, Christine Yee Yan; Xu, Kary J.Y.; Lam, Maco Cheuk Yin; Wong, G. W.K.; Leung, T. F.

Article 1

Diagnosis of fish and shellfish allergies

Journal of Asthma and Allergy, v. 11, p. 247-260
Tong, Wai Sze; Yuen, Agatha W.T.; Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.

Article 2

Low-Dose Allergen-Specific Immunotherapy Induces Tolerance in a Murine Model of Shrimp Allergy

International Archives of Allergy and Immunology, v. 174, (2), p. 86-96
Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Shu, Shang An; Chang, Christopher C.; Chu, Ka Hou; Leung, Patrick S.C.

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries

Cellular and Molecular Immunology, v. 14, (3), p. 308-318
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Ho, Marco H.K.; Liu, Ruiwu; Lam, Kit S.; Wang, Jin Jun; Shu, Shang An; Chu, Ka Hou; Leung, Patrick S.C.

Book chapter 1

Advances in seafood allergy research: Allergen detection and allergen-specific immunotherapy

Food Allergy / CRC Press, 2017, p. 80-105
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Chu, Ka Hou; Leung, Patrick S.C.

Conference paper 2

Clinical value of component-resolved diagnosis in fish allergy

Paper presented at Korean Academy of Allergy and Clinical Immunology Congress, Seoul, Korea, Republic of
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wong, G. W.K.; Leung, T. F.

Is testing for different allergen components useful in diagnosing IgE-mediated allergy to freshwater and seawater fishes?

Paper presented at European Academy of Allergy and Clinical Immunology Congress, Helsinki, Finland, p. 185
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wong, G. W.K.; Leung , T

Article 1

T cell epitope immunotherapy ameliorates allergic responses in a murine model of shrimp allergy

Clinical and Experimental Allergy, v. 46, (3), p. 491-503
Wai, C. Y.Y.; Leung, N. Y.H.; Leung, P. S.C.; Chu, K. H.

Conference paper 1

Mimotopes of the major shellfish allergen tropomyosin suppress splenocyte proliferation and local cytokine expression in a mouse model of shellfish allergy

LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Leung, Patrick S.C.; Chu, Ka Hou

Conference paper 1

Screening of OBOC peptide libraries with polyclonal IgE identifies mimotopes corresponding to immunodominant regions of the major shrimp allergen tropomyosin

Paper presented at The 2015 Hong Kong Inter-University Postgraduate Symposium in Life Sciences, , Hong Kong
LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Leung, Patrick S.C.; Chu, Ka Hou

Article 2

Current immunological and molecular biological perspectives on seafood allergy: A comprehensive review

Clinical Reviews in Allergy and Immunology, v. 46, (3), p. 180-197
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Shu, Shangan; Wang, Jinjun; Kenny, Thomas P.; Chu, Ka Hou; Leung, Patrick S.C.

Immunization with hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity

PLoS ONE, v. 9, (11), article number e111649
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Ho, Marco H.K.; Gershwin, Laurel J.; Shu, Shang An; Leung, Patrick S.C.; Chu, Ka Hou

Conference paper 1

High throughput screening of mimotopes using OBOC combinatorial peptide library: in silico and in vitro validation of mimicry potential and speciﬁcity for allergy treatment

LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Ho, Marco H.K.; Lam, K.; Leung, Patrick S.C.; Chu, Ka Hou

Article 1

From Molecular Studies of Allergens to Development of Immunotherapy of Allergies

Journal of Allergy & Therapy, v. 3, (3), article number 1000124
Wai, Christine Y.Y.; LEUNG, Yat Hin Nicki; Chu, Ka Hou; Leung, Patrick S.C.

2020 4

Characteristics of Chinese fish-allergic patients: Findings from double-blind placebo-controlled food challenges

Journal of Allergy and Clinical Immunology: In Practice, v. 8, (6), p. 2098-2100.e8
Leung, Agnes Sze Yin; Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Xu, Kary Jia Ying; Lam, Maco Cheuk Yin; Shum, Yuki Yuk; Lee, Tak Hong; Ho, Marco Hok Kung; Sou Da Rosa Duque, Jaime; Chua, Gilbert T.; Yau, Yat Sun; Chan, Wai Hung; Ho, Po Ki; Wong, Gary Wing Kin; Leung, Ting Fan
Article

Molecular and immunological characterization of grass carp (Ctenopharyngodon idella) parvalbumin Cten i 1: A major fish allergen in Hong Kong

Pediatric Allergy and Immunology, v. 31, (7), p. 792-804
Leung, Nicki Yat Hin; Leung, Agnes Sze Yin; Xu, Kary Jia Ying; Wai, Christine Yee Yan; Lam, Cheuk Yin; Wong, Gary Wing Kin; Leung, Ting Fan
Article

Overcoming shellfish allergy: How far have we come?

International journal of molecular sciences, v. 21, (6), article number 2234
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.; Leung, Agnes S.Y.; Wong, Gary W.K.; Leung, Ting Fan
Article

T-Cell Epitope Immunotherapy in Mouse Models of Food Allergy

Methods in Molecular Biology / Humana Press Inc., 2020, p. 337-355
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.
Book chapter

2019 6

Allergen immunotherapy for food allergy from the Asian perspective: key challenges and opportunities

Expert Review of Clinical Immunology, v. 15, (2), p. 153-164
Leung, Agnes Sze Yin; Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Leung, Ting Fan; Wong, Gary Wing Kin
Article

Immunotherapy of Food Allergy: a Comprehensive Review

Clinical Reviews in Allergy and Immunology, v. 57, (1), p. 55-73
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Patrick S.C.; Chu, Ka Hou
Article

Mimotope-based allergen-specific immunotherapy: ready for prime time?

Cellular and Molecular Immunology, v. 16, (11), p. 890-891
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Chu, Ka Hou; Leung, Patrick S.C.
Article

Modulating shrimp tropomyosin-mediated allergy: Hypoallergen DNA vaccines induce regulatory T cells to reduce hypersensitivity in mouse model

International journal of molecular sciences, v. 20, (18), article number 4656
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Leung, Patrick S.C.; Chu, Ka Hou
Article

Component-resolved Diagnosis of IgE-mediated Fish Allergy with Grass Carp Allergens

LEUNG, Yat Hin Nicki; Wai, Christine Y.Y.; Leung, Agnes Sze Yin; Wong MD , Gary WK.; Leung MD FRCPCH FAAAAI, Ting Fan
Conference paper

Differential IgE binding to freshwater and seawater fishes in a Chinese population offish allergic subjects

Paper presented at Abstracts from the European Academy of Allergy and Clinical Immunology Congress, Lisbon, Portugal, p. 471
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wai, Christine Yee Yan; Xu, Kary J.Y.; Lam, Maco Cheuk Yin; Wong, G. W.K.; Leung, T. F.
Conference paper

2018 1

Diagnosis of fish and shellfish allergies

Journal of Asthma and Allergy, v. 11, p. 247-260
Tong, Wai Sze; Yuen, Agatha W.T.; Wai, Christine Y.Y.; Leung, Nicki Y.H.; Chu, Ka Hou; Leung, Patrick S.C.
Article

2017 5

Low-Dose Allergen-Specific Immunotherapy Induces Tolerance in a Murine Model of Shrimp Allergy

International Archives of Allergy and Immunology, v. 174, (2), p. 86-96
Leung, Nicki Yat Hin; Wai, Christine Yee Yan; Shu, Shang An; Chang, Christopher C.; Chu, Ka Hou; Leung, Patrick S.C.
Article

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries

Cellular and Molecular Immunology, v. 14, (3), p. 308-318
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Ho, Marco H.K.; Liu, Ruiwu; Lam, Kit S.; Wang, Jin Jun; Shu, Shang An; Chu, Ka Hou; Leung, Patrick S.C.
Article

Advances in seafood allergy research: Allergen detection and allergen-specific immunotherapy

Food Allergy / CRC Press, 2017, p. 80-105
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Chu, Ka Hou; Leung, Patrick S.C.
Book chapter

Clinical value of component-resolved diagnosis in fish allergy

Paper presented at Korean Academy of Allergy and Clinical Immunology Congress, Seoul, Korea, Republic of
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wong, G. W.K.; Leung, T. F.
Conference paper

Is testing for different allergen components useful in diagnosing IgE-mediated allergy to freshwater and seawater fishes?

Paper presented at European Academy of Allergy and Clinical Immunology Congress, Helsinki, Finland, p. 185
LEUNG, Yat Hin Nicki; Leung, Agnes Sze Yin; Wong, G. W.K.; Leung , T
Conference paper

2016 2

T cell epitope immunotherapy ameliorates allergic responses in a murine model of shrimp allergy

Clinical and Experimental Allergy, v. 46, (3), p. 491-503
Wai, C. Y.Y.; Leung, N. Y.H.; Leung, P. S.C.; Chu, K. H.
Article

Mimotopes of the major shellfish allergen tropomyosin suppress splenocyte proliferation and local cytokine expression in a mouse model of shellfish allergy

LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Leung, Patrick S.C.; Chu, Ka Hou
Conference paper

2015 1

Screening of OBOC peptide libraries with polyclonal IgE identifies mimotopes corresponding to immunodominant regions of the major shrimp allergen tropomyosin

Paper presented at The 2015 Hong Kong Inter-University Postgraduate Symposium in Life Sciences, , Hong Kong
LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Leung, Patrick S.C.; Chu, Ka Hou
Conference paper

2014 3

Current immunological and molecular biological perspectives on seafood allergy: A comprehensive review

Clinical Reviews in Allergy and Immunology, v. 46, (3), p. 180-197
Leung, Nicki Y.H.; Wai, Christine Y.Y.; Shu, Shangan; Wang, Jinjun; Kenny, Thomas P.; Chu, Ka Hou; Leung, Patrick S.C.
Article

Immunization with hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity

PLoS ONE, v. 9, (11), article number e111649
Wai, Christine Y.Y.; Leung, Nicki Y.H.; Ho, Marco H.K.; Gershwin, Laurel J.; Shu, Shang An; Leung, Patrick S.C.; Chu, Ka Hou
Article

High throughput screening of mimotopes using OBOC combinatorial peptide library: in silico and in vitro validation of mimicry potential and speciﬁcity for allergy treatment

LEUNG, Yat Hin Nicki; Wai, Christine Yee Yan; Ho, Marco H.K.; Lam, K.; Leung, Patrick S.C.; Chu, Ka Hou
Conference paper

2012 1

From Molecular Studies of Allergens to Development of Immunotherapy of Allergies

Journal of Allergy & Therapy, v. 3, (3), article number 1000124
Wai, Christine Y.Y.; LEUNG, Yat Hin Nicki; Chu, Ka Hou; Leung, Patrick S.C.
Article

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Teaching Assignment

2025-26 Spring 3 2025-26 Winter 0 2025-26 Fall 0 2024-25 Summer 0 2024-25 Spring 0 2024-25 Winter 0

LIFS3580	Bioinformatics
LIFS6116I	Current Topics in Genomics and Bioinformatics
LIFS6800	Frontiers in Nucleic Acid Research

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From January 2024 to December 2026

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