Faculty Profiles - GAO Wenqing | The Hong Kong University of Science and Technology

Wenqing GAO
高文青

PhD in Biochemistry and Molecular Biology
National Institute of Biological Sciences, Beijing (Joint training program with China Agricultural University), 2017

Assistant Professor
Division of Life Science

(852) 2358 7257
gaowq@ust.hk
Room 5446

Google Scholar

q0HYNzwAAAAJ

Scopus ID

58368827100

Research Interest Publications

Research Interest

Immunology
Molecular mechanisms of neurodegeneration
Neurodegenerative and age-related disorders
Spinal cord / optic nerve injury

Publications

All Years 19 2026 0 2025 1 2024 2 2023 1 2022 0 2021 0 2020 15

2025 1

Endogenous self-peptides guard immune privilege of the central nervous system

Nature, v. 637, (8044), p. 176-183
Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F.M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe, Clair; Artyomov, Maxim N.; Unanue, Emil R.; Kipnis, Jonathan
Article

2024 2

Engineered T cell therapy for central nervous system injury

Nature, v. 634, p. 693-701
GAO, Wenqing; Kim, Min Woo; Dykstra, Taitea; Du, Siling; Boskovic, Pavle; Lichti, Cheryl F.; Ruiz-Cardozo, Miguel A.; Gu, Xingxing; Weizman Shapira, Tal; Rustenhoven, Justin; Molina, Camilo; Smirnov, Igor; Merbl, Yifat; Ray, Wilson Z.; Kipnis, Jonathan
Article

Will cellular immunotherapies end neurodegenerative diseases?

Trends in Immunology, v. 45, (5), p. 329-337
Boskovic, Pavle; Gao, Wenqing; Kipnis, Jonathan
Article

2023 1

Age-dependent immune and lymphatic responses after spinal cord injury

Neuron, v. 111, (14), p. 2155-2169.e9
Salvador, Andrea Francesca M.; Dykstra, Taitea; Rustenhoven, Justin; Gao, Wenqing; Blackburn, Susan M.; Bhasiin, Kesshni; Dong, Michael Q.; Guimarães, Rafaela Mano; Gonuguntla, Sriharsha; Smirnov, Igor; Kipnis, Jonathan; Herz, Jasmin
Article

2020 1

A bioorthogonal system reveals antitumour immune function of pyroptosis

Nature, v. 579, (7799), p. 421-426
Wang, Qinyang; Wang, Yupeng; Ding, Jingjin; Wang, Chunhong; Zhou, Xuehan; Gao, Wenqing; Huang, Huanwei; Shao, Feng; Liu, Zhibo
Article

2019 1

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

Cell, v. 178, (3), p. 552-566.e20
Xu, Yue; Zhou, Ping; Cheng, Sen; Lu, Qiuhe; Nowak, Kathrin; Hopp, Ann Katrin; Li, Lin; Shi, Xuyan; Zhou, Zhiwei; Gao, Wenqing; Li, Da; He, Huabin; Liu, Xiaoyun; Ding, Jingjin; Hottiger, Michael O.; Shao, Feng
Article

2018 2

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

Nature, v. 561, (7721), p. 122-126
Zhou, Ping; She, Yang; Dong, Na; Li, Peng; He, Huabin; Borio, Alessio; Wu, Qingcui; Lu, Shan; Ding, Xiaojun; Cao, Yong; Xu, Yue; Gao, Wenqing; Dong, Mengqiu; Ding, Jingjin; Wang, Da Cheng; Zamyatina, Alla; Shao, Feng
Article

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

Cell Reports, v. 25, (9), p. 2339-2353.e4
Vince, James E.; De Nardo, Dominic; Gao, Wenqing; Vince, Angelina J.; Hall, Cathrine; McArthur, Kate; Simpson, Daniel; Vijayaraj, Swarna; Lindqvist, Lisa M.; Bouillet, Philippe; Rizzacasa, Mark A.; Man, Si Ming; Silke, John; Masters, Seth L.; Lessene, Guillaume; Huang, David C.S.; Gray, Daniel H.D.; Kile, Benjamin T.; Shao, Feng; Lawlor, Kate E.
Article

2017 2

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Nature, v. 547, (7661), p. 99-103
Wang, Yupeng; Gao, Wenqing; Shi, Xuyan; Ding, Jingjin; Liu, Wang; He, Huabin; Wang, Kun; Shao, Feng
Article

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Trends in Biochemical Sciences, v. 42, (4), p. 245-254
Shi, Jianjin; Gao, Wenqing; Shao, Feng
Article

2016 2

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation

Cell Host and Microbe, v. 19, (5), p. 664-674
Aubert, Daniel F.; Xu, Hao; Yang, Jieling; Shi, Xuyan; Gao, Wenqing; Li, Lin; Bisaro, Fabiana; Chen, She; Valvano, Miguel A.; Shao, Feng
Article

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (33), p. E4857-E4866
Gao, Wenqing; Yang, Jieling; Liu, Wang; Wang, Yupeng; Shao, Feng
Article

2014 4

An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis

Cell Host and Microbe, v. 16, (3), p. 351-363
Lu, Qiuhe; Yao, Qing; Xu, Yue; Li, Lin; Li, Shan; Liu, Yanhua; Gao, Wenqing; Niu, Miao; Sharon, Michal; Ben-Nissan, Gili; Zamyatina, Alla; Liu, Xiaoyun; Chen, She; Shao, Feng
Article

Inflammatory caspases are innate immune receptors for intracellular LPS

Nature, v. 514, (7521), p. 187-192
Shi, Jianjin; Zhao, Yue; Wang, Yupeng; Gao, Wenqing; Ding, Jingjin; Li, Peng; Hu, Liyan; Shao, Feng
Article

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Nature, v. 513, (7517), p. 237-241
Xu, Hao; Yang, Jieling; Gao, Wenqing; Li, Lin; Li, Peng; Zhang, Li; Gong, Yi Nan; Peng, Xiaolan; Xi, Jianzhong Jeff; Chen, She; Wang, Fengchao; Shao, Feng
Article

Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus

Journal of Virology, v. 88, (1), p. 237-248
Sun, Yinyan; Qi, Yonghe; Liu, Chenxuan; Gao, Wenqing; Chen, Pan; Fu, Liran; Peng, Bo; Wang, Haimin; Jing, Zhiyi; Zhong, Guocai; Li, Wenhui
Article

2013 1

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

Nature, v. 501, (7466), p. 242-246
Li, Shan; Zhang, Li; Yao, Qing; Li, Lin; Dong, Na; Rong, Jie; Gao, Wenqing; Ding, Xiaojun; Sun, Liming; Chen, Xing; Chen, She; Shao, Feng
Article

2012 2

Hemokinin-1 as an adjuvant molecule enhancing humoral and memory responses to HBsAg DNA vaccination

Viral immunology, v. 25, (4), p. 289-296
Chen, Xuan; Zhang, Wang; Gao, Wenqing; Zou, Qiang; Feng, Congcong; Liu, Hu; Zhou, Chenliang; Zhang, Yu; Wang, Bin
Article

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

eLife, v. 2012, (1), article number e00049
Yan, Huan; Zhong, Guocai; Xu, Guangwei; He, Wenhui; Jing, Zhiyi; Gao, Zhenchao; Huang, Yi; Qi, Yonghe; Peng, Bo; Wang, Haimin; Fu, Liran; Song, Mei; Chen, Pan; Gao, Wenqing; Ren, Bijie; Sun, Yinyan; Cai, Tao; Feng, Xiaofeng; Sui, Jianhua; Li, Wenhui
Article

Article 1

Endogenous self-peptides guard immune privilege of the central nervous system

Nature, v. 637, (8044), p. 176-183
Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F.M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe, Clair; Artyomov, Maxim N.; Unanue, Emil R.; Kipnis, Jonathan

Article 2

Engineered T cell therapy for central nervous system injury

Nature, v. 634, p. 693-701
GAO, Wenqing; Kim, Min Woo; Dykstra, Taitea; Du, Siling; Boskovic, Pavle; Lichti, Cheryl F.; Ruiz-Cardozo, Miguel A.; Gu, Xingxing; Weizman Shapira, Tal; Rustenhoven, Justin; Molina, Camilo; Smirnov, Igor; Merbl, Yifat; Ray, Wilson Z.; Kipnis, Jonathan

Will cellular immunotherapies end neurodegenerative diseases?

Trends in Immunology, v. 45, (5), p. 329-337
Boskovic, Pavle; Gao, Wenqing; Kipnis, Jonathan

Article 1

Age-dependent immune and lymphatic responses after spinal cord injury

Neuron, v. 111, (14), p. 2155-2169.e9
Salvador, Andrea Francesca M.; Dykstra, Taitea; Rustenhoven, Justin; Gao, Wenqing; Blackburn, Susan M.; Bhasiin, Kesshni; Dong, Michael Q.; Guimarães, Rafaela Mano; Gonuguntla, Sriharsha; Smirnov, Igor; Kipnis, Jonathan; Herz, Jasmin

Article 1

A bioorthogonal system reveals antitumour immune function of pyroptosis

Nature, v. 579, (7799), p. 421-426
Wang, Qinyang; Wang, Yupeng; Ding, Jingjin; Wang, Chunhong; Zhou, Xuehan; Gao, Wenqing; Huang, Huanwei; Shao, Feng; Liu, Zhibo

Article 1

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

Cell, v. 178, (3), p. 552-566.e20
Xu, Yue; Zhou, Ping; Cheng, Sen; Lu, Qiuhe; Nowak, Kathrin; Hopp, Ann Katrin; Li, Lin; Shi, Xuyan; Zhou, Zhiwei; Gao, Wenqing; Li, Da; He, Huabin; Liu, Xiaoyun; Ding, Jingjin; Hottiger, Michael O.; Shao, Feng

Article 2

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

Nature, v. 561, (7721), p. 122-126
Zhou, Ping; She, Yang; Dong, Na; Li, Peng; He, Huabin; Borio, Alessio; Wu, Qingcui; Lu, Shan; Ding, Xiaojun; Cao, Yong; Xu, Yue; Gao, Wenqing; Dong, Mengqiu; Ding, Jingjin; Wang, Da Cheng; Zamyatina, Alla; Shao, Feng

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

Cell Reports, v. 25, (9), p. 2339-2353.e4
Vince, James E.; De Nardo, Dominic; Gao, Wenqing; Vince, Angelina J.; Hall, Cathrine; McArthur, Kate; Simpson, Daniel; Vijayaraj, Swarna; Lindqvist, Lisa M.; Bouillet, Philippe; Rizzacasa, Mark A.; Man, Si Ming; Silke, John; Masters, Seth L.; Lessene, Guillaume; Huang, David C.S.; Gray, Daniel H.D.; Kile, Benjamin T.; Shao, Feng; Lawlor, Kate E.

Article 2

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Nature, v. 547, (7661), p. 99-103
Wang, Yupeng; Gao, Wenqing; Shi, Xuyan; Ding, Jingjin; Liu, Wang; He, Huabin; Wang, Kun; Shao, Feng

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Trends in Biochemical Sciences, v. 42, (4), p. 245-254
Shi, Jianjin; Gao, Wenqing; Shao, Feng

Article 2

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation

Cell Host and Microbe, v. 19, (5), p. 664-674
Aubert, Daniel F.; Xu, Hao; Yang, Jieling; Shi, Xuyan; Gao, Wenqing; Li, Lin; Bisaro, Fabiana; Chen, She; Valvano, Miguel A.; Shao, Feng

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (33), p. E4857-E4866
Gao, Wenqing; Yang, Jieling; Liu, Wang; Wang, Yupeng; Shao, Feng

Article 4

An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis

Cell Host and Microbe, v. 16, (3), p. 351-363
Lu, Qiuhe; Yao, Qing; Xu, Yue; Li, Lin; Li, Shan; Liu, Yanhua; Gao, Wenqing; Niu, Miao; Sharon, Michal; Ben-Nissan, Gili; Zamyatina, Alla; Liu, Xiaoyun; Chen, She; Shao, Feng

Inflammatory caspases are innate immune receptors for intracellular LPS

Nature, v. 514, (7521), p. 187-192
Shi, Jianjin; Zhao, Yue; Wang, Yupeng; Gao, Wenqing; Ding, Jingjin; Li, Peng; Hu, Liyan; Shao, Feng

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Nature, v. 513, (7517), p. 237-241
Xu, Hao; Yang, Jieling; Gao, Wenqing; Li, Lin; Li, Peng; Zhang, Li; Gong, Yi Nan; Peng, Xiaolan; Xi, Jianzhong Jeff; Chen, She; Wang, Fengchao; Shao, Feng

Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus

Journal of Virology, v. 88, (1), p. 237-248
Sun, Yinyan; Qi, Yonghe; Liu, Chenxuan; Gao, Wenqing; Chen, Pan; Fu, Liran; Peng, Bo; Wang, Haimin; Jing, Zhiyi; Zhong, Guocai; Li, Wenhui

Article 1

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

Nature, v. 501, (7466), p. 242-246
Li, Shan; Zhang, Li; Yao, Qing; Li, Lin; Dong, Na; Rong, Jie; Gao, Wenqing; Ding, Xiaojun; Sun, Liming; Chen, Xing; Chen, She; Shao, Feng

Article 2

Hemokinin-1 as an adjuvant molecule enhancing humoral and memory responses to HBsAg DNA vaccination

Viral immunology, v. 25, (4), p. 289-296
Chen, Xuan; Zhang, Wang; Gao, Wenqing; Zou, Qiang; Feng, Congcong; Liu, Hu; Zhou, Chenliang; Zhang, Yu; Wang, Bin

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

eLife, v. 2012, (1), article number e00049
Yan, Huan; Zhong, Guocai; Xu, Guangwei; He, Wenhui; Jing, Zhiyi; Gao, Zhenchao; Huang, Yi; Qi, Yonghe; Peng, Bo; Wang, Haimin; Fu, Liran; Song, Mei; Chen, Pan; Gao, Wenqing; Ren, Bijie; Sun, Yinyan; Cai, Tao; Feng, Xiaofeng; Sui, Jianhua; Li, Wenhui

2020 1

A bioorthogonal system reveals antitumour immune function of pyroptosis

Nature, v. 579, (7799), p. 421-426
Wang, Qinyang; Wang, Yupeng; Ding, Jingjin; Wang, Chunhong; Zhou, Xuehan; Gao, Wenqing; Huang, Huanwei; Shao, Feng; Liu, Zhibo
Article

2019 1

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

Cell, v. 178, (3), p. 552-566.e20
Xu, Yue; Zhou, Ping; Cheng, Sen; Lu, Qiuhe; Nowak, Kathrin; Hopp, Ann Katrin; Li, Lin; Shi, Xuyan; Zhou, Zhiwei; Gao, Wenqing; Li, Da; He, Huabin; Liu, Xiaoyun; Ding, Jingjin; Hottiger, Michael O.; Shao, Feng
Article

2018 2

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

Nature, v. 561, (7721), p. 122-126
Zhou, Ping; She, Yang; Dong, Na; Li, Peng; He, Huabin; Borio, Alessio; Wu, Qingcui; Lu, Shan; Ding, Xiaojun; Cao, Yong; Xu, Yue; Gao, Wenqing; Dong, Mengqiu; Ding, Jingjin; Wang, Da Cheng; Zamyatina, Alla; Shao, Feng
Article

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

Cell Reports, v. 25, (9), p. 2339-2353.e4
Vince, James E.; De Nardo, Dominic; Gao, Wenqing; Vince, Angelina J.; Hall, Cathrine; McArthur, Kate; Simpson, Daniel; Vijayaraj, Swarna; Lindqvist, Lisa M.; Bouillet, Philippe; Rizzacasa, Mark A.; Man, Si Ming; Silke, John; Masters, Seth L.; Lessene, Guillaume; Huang, David C.S.; Gray, Daniel H.D.; Kile, Benjamin T.; Shao, Feng; Lawlor, Kate E.
Article

2017 2

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Nature, v. 547, (7661), p. 99-103
Wang, Yupeng; Gao, Wenqing; Shi, Xuyan; Ding, Jingjin; Liu, Wang; He, Huabin; Wang, Kun; Shao, Feng
Article

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Trends in Biochemical Sciences, v. 42, (4), p. 245-254
Shi, Jianjin; Gao, Wenqing; Shao, Feng
Article

2016 2

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation

Cell Host and Microbe, v. 19, (5), p. 664-674
Aubert, Daniel F.; Xu, Hao; Yang, Jieling; Shi, Xuyan; Gao, Wenqing; Li, Lin; Bisaro, Fabiana; Chen, She; Valvano, Miguel A.; Shao, Feng
Article

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (33), p. E4857-E4866
Gao, Wenqing; Yang, Jieling; Liu, Wang; Wang, Yupeng; Shao, Feng
Article

2014 4

An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis

Cell Host and Microbe, v. 16, (3), p. 351-363
Lu, Qiuhe; Yao, Qing; Xu, Yue; Li, Lin; Li, Shan; Liu, Yanhua; Gao, Wenqing; Niu, Miao; Sharon, Michal; Ben-Nissan, Gili; Zamyatina, Alla; Liu, Xiaoyun; Chen, She; Shao, Feng
Article

Inflammatory caspases are innate immune receptors for intracellular LPS

Nature, v. 514, (7521), p. 187-192
Shi, Jianjin; Zhao, Yue; Wang, Yupeng; Gao, Wenqing; Ding, Jingjin; Li, Peng; Hu, Liyan; Shao, Feng
Article

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Nature, v. 513, (7517), p. 237-241
Xu, Hao; Yang, Jieling; Gao, Wenqing; Li, Lin; Li, Peng; Zhang, Li; Gong, Yi Nan; Peng, Xiaolan; Xi, Jianzhong Jeff; Chen, She; Wang, Fengchao; Shao, Feng
Article

Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus

Journal of Virology, v. 88, (1), p. 237-248
Sun, Yinyan; Qi, Yonghe; Liu, Chenxuan; Gao, Wenqing; Chen, Pan; Fu, Liran; Peng, Bo; Wang, Haimin; Jing, Zhiyi; Zhong, Guocai; Li, Wenhui
Article

2013 1

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

Nature, v. 501, (7466), p. 242-246
Li, Shan; Zhang, Li; Yao, Qing; Li, Lin; Dong, Na; Rong, Jie; Gao, Wenqing; Ding, Xiaojun; Sun, Liming; Chen, Xing; Chen, She; Shao, Feng
Article

2012 2

Hemokinin-1 as an adjuvant molecule enhancing humoral and memory responses to HBsAg DNA vaccination

Viral immunology, v. 25, (4), p. 289-296
Chen, Xuan; Zhang, Wang; Gao, Wenqing; Zou, Qiang; Feng, Congcong; Liu, Hu; Zhou, Chenliang; Zhang, Yu; Wang, Bin
Article

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

eLife, v. 2012, (1), article number e00049
Yan, Huan; Zhong, Guocai; Xu, Guangwei; He, Wenhui; Jing, Zhiyi; Gao, Zhenchao; Huang, Yi; Qi, Yonghe; Peng, Bo; Wang, Haimin; Fu, Liran; Song, Mei; Chen, Pan; Gao, Wenqing; Ren, Bijie; Sun, Yinyan; Cai, Tao; Feng, Xiaofeng; Sui, Jianhua; Li, Wenhui
Article

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Research Interest

Publications

2025 1

2024 2

2023 1

2020 1

2019 1

2018 2

2017 2

2016 2

2014 4

2013 1

2012 2

Article 1

Article 2

Article 1

Article 1

Article 1

Article 2

Article 2

Article 2

Article 4

Article 1

Article 2

2020 1

2019 1

2018 2

2017 2

2016 2

2014 4

2013 1

2012 2

Projects

From January 2024 to December 2026

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