Faculty Profiles - SIN Tsz Kwan | The Hong Kong University of Science and Technology

Tsz Kwan SIN
冼子君

PhD in Cancer Genetics
The University of Hong Kong, 2018

Research Assistant Professor
Division of Life Science

(852) 2358 7316
sarahsin@ust.hk
Room 6201

ResearcherID

FWE-7135-2022

Scopus ID

57210900417

Research Interest Publications

Research Interest

Aging
Molecular biology
Muscle differentiation and regeneration
Muscle stem cells

Publications

All Years 7 2025 0 2024 0 2023 0 2022 1 2021 1 2020 1 2019 4

2022 1

Effects of nucleases on cell-free extrachromosomal circular DNA

JCI Insight, v. 7, (8), April 2022, article number e156070
Sin, Sarah T.K.; Deng, Jiaen; Ji, Lu; Yukawa, Masashi; Chan, Rebecca W.Y.; Volpi, Stefano; Vaglio, Augusto; Fenaroli, Paride; Bocca, Paola; Cheng, Suk Hang; Wong, Danny K.L.; Lui, Kathy O.; Jiang, Peiyong; Allen Chan, K.C.; Chiu, Rossa W.K.; Dennis Lo, Y.M.
Article

2021 1

Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance

Clinical Chemistry, v. 67, (5), May 2021, p. 788-796
Sin, Sarah T. K; Ji, Lu; Deng, Jiaen; Jiang, Peiyong; Cheng, Suk Hang; Heung, Macy M. S; Lau, Caitlyn S. L; Leung, Tak Y; Chan, K. C. Allen; Chiu, Rossa W. K; Lo, Y. M. Dennis
Article

2020 1

Identification and characterization of extrachromosomal circular DNA in maternal plasma

Proceedings of the National Academy of Sciences of the United States of America, v. 117, (3), January 2020, p. 1658-1665
Sin, Sarah T.K.; Jiang, Peiyong; Deng, Jiaen; Ji, Lu; Cheng, Suk Hang; Dutta, Anindya; Leung, Tak Y.; Chan, K.C. Allen; Chiu, Rossa W.K.; Lo, Y.M. Dennis
Article

2019 2

Topologic analysis of plasma mitochondrial DNA reveals the coexistence of both linear and circular molecules

Clinical Chemistry, v. 65, (9), September 2019, p. 1161-1170
Ma, Mary-Jane L.; Zhang, Haiqiang; Jiang, Peiyong; Sin, Sarah T.K.; Lam, Wai Kei Jacky; Cheng, Suk Hang; Lee, Wing-Shan; Gai, Wanxia; Olivia Tse, O.Y.; Peng, Wenlei; Wong, John; Raghupathy, Radha; Wong, Raymond S.M.; Sahota, Daljit; Leung, Tak Y.; Allen Chan, K.C.; Chiu, Rossa W.K.; Dennis Lo, Y.M.
Article

TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling

Gynecologic Oncology, v. 152, (1), January 2019, p. 185-193
Sin, Tsz Kwan; Li, Yan; Liu, Ming; Ma, Stephanie; Guan, Xin-Yuan
Article

2018 1

Down-regulation of TROP-2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients

Hepatology Communications, v. 2, (11), November 2018, p. 1408-1414
Sin, Sarah T. K.; Li, Yan; Liu, Ming; Yuan, Yun-Fei; Ma, Stephanie; Guan, Xin-Yuan
Article

2016 1

AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways

Oncotarget, v. 8, (48), October 2016, p. 83469-83479
Chow, Raymond Kwok Kei; Sin, Tsz Kwan; Liu, Ming; Li, Yan; Chan, Tim Hon Man; Song, Yangyang; Chen, Leilei; Kwong, Dora Lai-Wan; Guan, Xin-Yuan
Article

Article 1

Effects of nucleases on cell-free extrachromosomal circular DNA

JCI Insight, v. 7, (8), April 2022, article number e156070
Sin, Sarah T.K.; Deng, Jiaen; Ji, Lu; Yukawa, Masashi; Chan, Rebecca W.Y.; Volpi, Stefano; Vaglio, Augusto; Fenaroli, Paride; Bocca, Paola; Cheng, Suk Hang; Wong, Danny K.L.; Lui, Kathy O.; Jiang, Peiyong; Allen Chan, K.C.; Chiu, Rossa W.K.; Dennis Lo, Y.M.

Article 1

Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance

Clinical Chemistry, v. 67, (5), May 2021, p. 788-796
Sin, Sarah T. K; Ji, Lu; Deng, Jiaen; Jiang, Peiyong; Cheng, Suk Hang; Heung, Macy M. S; Lau, Caitlyn S. L; Leung, Tak Y; Chan, K. C. Allen; Chiu, Rossa W. K; Lo, Y. M. Dennis

Article 1

Identification and characterization of extrachromosomal circular DNA in maternal plasma

Proceedings of the National Academy of Sciences of the United States of America, v. 117, (3), January 2020, p. 1658-1665
Sin, Sarah T.K.; Jiang, Peiyong; Deng, Jiaen; Ji, Lu; Cheng, Suk Hang; Dutta, Anindya; Leung, Tak Y.; Chan, K.C. Allen; Chiu, Rossa W.K.; Lo, Y.M. Dennis

Article 2

Topologic analysis of plasma mitochondrial DNA reveals the coexistence of both linear and circular molecules

Clinical Chemistry, v. 65, (9), September 2019, p. 1161-1170
Ma, Mary-Jane L.; Zhang, Haiqiang; Jiang, Peiyong; Sin, Sarah T.K.; Lam, Wai Kei Jacky; Cheng, Suk Hang; Lee, Wing-Shan; Gai, Wanxia; Olivia Tse, O.Y.; Peng, Wenlei; Wong, John; Raghupathy, Radha; Wong, Raymond S.M.; Sahota, Daljit; Leung, Tak Y.; Allen Chan, K.C.; Chiu, Rossa W.K.; Dennis Lo, Y.M.

TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling

Gynecologic Oncology, v. 152, (1), January 2019, p. 185-193
Sin, Tsz Kwan; Li, Yan; Liu, Ming; Ma, Stephanie; Guan, Xin-Yuan

Article 1

Down-regulation of TROP-2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients

Hepatology Communications, v. 2, (11), November 2018, p. 1408-1414
Sin, Sarah T. K.; Li, Yan; Liu, Ming; Yuan, Yun-Fei; Ma, Stephanie; Guan, Xin-Yuan

Article 1

AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways

Oncotarget, v. 8, (48), October 2016, p. 83469-83479
Chow, Raymond Kwok Kei; Sin, Tsz Kwan; Liu, Ming; Li, Yan; Chan, Tim Hon Man; Song, Yangyang; Chen, Leilei; Kwong, Dora Lai-Wan; Guan, Xin-Yuan

2019 2

Topologic analysis of plasma mitochondrial DNA reveals the coexistence of both linear and circular molecules

Clinical Chemistry, v. 65, (9), September 2019, p. 1161-1170
Ma, Mary-Jane L.; Zhang, Haiqiang; Jiang, Peiyong; Sin, Sarah T.K.; Lam, Wai Kei Jacky; Cheng, Suk Hang; Lee, Wing-Shan; Gai, Wanxia; Olivia Tse, O.Y.; Peng, Wenlei; Wong, John; Raghupathy, Radha; Wong, Raymond S.M.; Sahota, Daljit; Leung, Tak Y.; Allen Chan, K.C.; Chiu, Rossa W.K.; Dennis Lo, Y.M.
Article

TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling

Gynecologic Oncology, v. 152, (1), January 2019, p. 185-193
Sin, Tsz Kwan; Li, Yan; Liu, Ming; Ma, Stephanie; Guan, Xin-Yuan
Article

2018 1

Down-regulation of TROP-2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients

Hepatology Communications, v. 2, (11), November 2018, p. 1408-1414
Sin, Sarah T. K.; Li, Yan; Liu, Ming; Yuan, Yun-Fei; Ma, Stephanie; Guan, Xin-Yuan
Article

2016 1

AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways

Oncotarget, v. 8, (48), October 2016, p. 83469-83479
Chow, Raymond Kwok Kei; Sin, Tsz Kwan; Liu, Ming; Li, Yan; Chan, Tim Hon Man; Song, Yangyang; Chen, Leilei; Kwong, Dora Lai-Wan; Guan, Xin-Yuan
Article

No Publications

Research Interest

Publications

2022 1

2021 1

2020 1

2019 2

2018 1

2016 1

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2019 2

2018 1

2016 1

Projects

From January 2023 to December 2025

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