Faculty Profiles - SIN Tsz Kwan | The Hong Kong University of Science and Technology

Tsz Kwan SIN
冼子君

PhD in Cancer Genetics
The University of Hong Kong, 2018

Research Assistant Professor
Division of Life Science

(852) 2358 7316
sarahsin@ust.hk
Room 6201F

ResearcherID

FWE-7135-2022

Scopus ID

57210900417

Research Interest Publications

Research Interest

Aging
Molecular biology
Muscle differentiation and regeneration
Muscle stem cells

Publications

All Years 7 2026 0 2025 0 2024 0 2023 0 2022 1 2021 1 2020 5

2022 1

Effects of nucleases on cell-free extrachromosomal circular DNA

JCI Insight, v. 7, (8), article number e156070
Sin, Sarah T.K.; Deng, Jiaen; Ji, Lu; Yukawa, Masashi; Chan, Rebecca W.Y.; Volpi, Stefano; Vaglio, Augusto; Fenaroli, Paride; Bocca, Paola; Cheng, Suk Hang; Wong, Danny K.L.; Lui, Kathy O.; Jiang, Peiyong; Allen Chan, K. C.; Chiu, Rossa W.K.; Dennis Lo, Y. M.
Article

2021 1

Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance

Clinical Chemistry, v. 67, (5), p. 788-796
Sin, Sarah T.K.; Ji, Lu; Deng, Jiaen; Jiang, Peiyong; Cheng, Suk Hang; Heung, Macy M.S.; Lau, Caitlyn S.L.; Leung, Tak Y.; Chan, K. C.Allen; Chiu, Rossa W.K.; Lo, Y. M.Dennis
Article

2020 1

Identification and characterization of extrachromosomal circular DNA in maternal plasma

Proceedings of the National Academy of Sciences of the United States of America, v. 117, (3), p. 1658-1665
Sin, Sarah T.K.; Jiang, Peiyong; Deng, Jiaen; Ji, Lu; Cheng, Suk Hang; Dutta, Anindya; Leung, Tak Y.; Chan, K. C.Allen; Chiu, Rossa W.K.; Lo, Y. M.Dennis
Article

2019 2

Topologic analysis of plasma mitochondrial DNA reveals the coexistence of both linear and circular molecules

Clinical Chemistry, v. 65, (9), p. 1161-1170
Ma, Mary Jane L.; Zhang, Haiqiang; Jiang, Peiyong; Sin, Sarah T.K.; Lam, Wai Kei Jacky; Cheng, Suk Hang; Lee, Wing Shan; Gai, Wanxia; Olivia Tse, O. Y.; Peng, Wenlei; Wong, John; Raghupathy, Radha; Wong, Raymond S.M.; Sahota, Daljit; Leung, Tak Y.; Allen Chan, K. C.; Chiu, Rossa W.K.; Dennis Lo, Y. M.
Article

TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling

Gynecologic Oncology, v. 152, (1), p. 185-193
Sin, Sarah T.K.; Li, Yan; Liu, Ming; Ma, Stephanie; Guan, Xin Yuan
Article

2018 1

Down-regulation of TROP-2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients

Hepatology Communications, v. 2, (11), p. 1408-1414
Sin, Sarah T.K.; Li, Yan; Liu, Ming; Yuan, Yun Fei; Ma, Stephanie; Guan, Xin Yuan
Article

2017 1

AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways

Oncotarget, v. 8, (48), p. 83469-83479
Chow, Raymond Kwok Kei; Sin, Sarah Tsz Kwan; Liu, Ming; Li, Yan; Chan, Tim Hon Man; Song, Yangyang; Chen, Leilei; Kwong, Dora Lai Wan; Guan, Xin Yuan
Article

Article 1

Effects of nucleases on cell-free extrachromosomal circular DNA

JCI Insight, v. 7, (8), article number e156070
Sin, Sarah T.K.; Deng, Jiaen; Ji, Lu; Yukawa, Masashi; Chan, Rebecca W.Y.; Volpi, Stefano; Vaglio, Augusto; Fenaroli, Paride; Bocca, Paola; Cheng, Suk Hang; Wong, Danny K.L.; Lui, Kathy O.; Jiang, Peiyong; Allen Chan, K. C.; Chiu, Rossa W.K.; Dennis Lo, Y. M.

Article 1

Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance

Clinical Chemistry, v. 67, (5), p. 788-796
Sin, Sarah T.K.; Ji, Lu; Deng, Jiaen; Jiang, Peiyong; Cheng, Suk Hang; Heung, Macy M.S.; Lau, Caitlyn S.L.; Leung, Tak Y.; Chan, K. C.Allen; Chiu, Rossa W.K.; Lo, Y. M.Dennis

Article 1

Identification and characterization of extrachromosomal circular DNA in maternal plasma

Proceedings of the National Academy of Sciences of the United States of America, v. 117, (3), p. 1658-1665
Sin, Sarah T.K.; Jiang, Peiyong; Deng, Jiaen; Ji, Lu; Cheng, Suk Hang; Dutta, Anindya; Leung, Tak Y.; Chan, K. C.Allen; Chiu, Rossa W.K.; Lo, Y. M.Dennis

Article 2

Topologic analysis of plasma mitochondrial DNA reveals the coexistence of both linear and circular molecules

Clinical Chemistry, v. 65, (9), p. 1161-1170
Ma, Mary Jane L.; Zhang, Haiqiang; Jiang, Peiyong; Sin, Sarah T.K.; Lam, Wai Kei Jacky; Cheng, Suk Hang; Lee, Wing Shan; Gai, Wanxia; Olivia Tse, O. Y.; Peng, Wenlei; Wong, John; Raghupathy, Radha; Wong, Raymond S.M.; Sahota, Daljit; Leung, Tak Y.; Allen Chan, K. C.; Chiu, Rossa W.K.; Dennis Lo, Y. M.

TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling

Gynecologic Oncology, v. 152, (1), p. 185-193
Sin, Sarah T.K.; Li, Yan; Liu, Ming; Ma, Stephanie; Guan, Xin Yuan

Article 1

Down-regulation of TROP-2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients

Hepatology Communications, v. 2, (11), p. 1408-1414
Sin, Sarah T.K.; Li, Yan; Liu, Ming; Yuan, Yun Fei; Ma, Stephanie; Guan, Xin Yuan

Article 1

AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways

Oncotarget, v. 8, (48), p. 83469-83479
Chow, Raymond Kwok Kei; Sin, Sarah Tsz Kwan; Liu, Ming; Li, Yan; Chan, Tim Hon Man; Song, Yangyang; Chen, Leilei; Kwong, Dora Lai Wan; Guan, Xin Yuan

2020 1

Identification and characterization of extrachromosomal circular DNA in maternal plasma

Proceedings of the National Academy of Sciences of the United States of America, v. 117, (3), p. 1658-1665
Sin, Sarah T.K.; Jiang, Peiyong; Deng, Jiaen; Ji, Lu; Cheng, Suk Hang; Dutta, Anindya; Leung, Tak Y.; Chan, K. C.Allen; Chiu, Rossa W.K.; Lo, Y. M.Dennis
Article

2019 2

Topologic analysis of plasma mitochondrial DNA reveals the coexistence of both linear and circular molecules

Clinical Chemistry, v. 65, (9), p. 1161-1170
Ma, Mary Jane L.; Zhang, Haiqiang; Jiang, Peiyong; Sin, Sarah T.K.; Lam, Wai Kei Jacky; Cheng, Suk Hang; Lee, Wing Shan; Gai, Wanxia; Olivia Tse, O. Y.; Peng, Wenlei; Wong, John; Raghupathy, Radha; Wong, Raymond S.M.; Sahota, Daljit; Leung, Tak Y.; Allen Chan, K. C.; Chiu, Rossa W.K.; Dennis Lo, Y. M.
Article

TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling

Gynecologic Oncology, v. 152, (1), p. 185-193
Sin, Sarah T.K.; Li, Yan; Liu, Ming; Ma, Stephanie; Guan, Xin Yuan
Article

2018 1

Down-regulation of TROP-2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients

Hepatology Communications, v. 2, (11), p. 1408-1414
Sin, Sarah T.K.; Li, Yan; Liu, Ming; Yuan, Yun Fei; Ma, Stephanie; Guan, Xin Yuan
Article

2017 1

AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways

Oncotarget, v. 8, (48), p. 83469-83479
Chow, Raymond Kwok Kei; Sin, Sarah Tsz Kwan; Liu, Ming; Li, Yan; Chan, Tim Hon Man; Song, Yangyang; Chen, Leilei; Kwong, Dora Lai Wan; Guan, Xin Yuan
Article

No Publications

Research Interest

Publications

2022 1

2021 1

2020 1

2019 2

2018 1

2017 1

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Article 2

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2019 2

2018 1

2017 1

Projects

From January 2024 to December 2026

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