Faculty Profiles - CHAN Simon Wan | The Hong Kong University of Science and Technology

Simon Wan CHAN
陳雲

PhD in Bioanalytical Chemistry
Hong Kong Baptist University, 2007

Professor
Department of Chemistry
Division of Environment and Sustainability

(852) 2358 7370
chanwan@ust.hk
Room 4517
Personal Web

ORCID

0000-0001-8479-3172

Scopus ID

7403917961

Research Interest Publications Projects Teaching Assignment RPG Supervision Space used

Research Interest

Analytical chemistry
Bioanalytical chemistry
Chemical toxicology
Food chemistry
Mass spectrometry

Publications

All Years 112 2024 4 2023 5 2022 5 2021 9 2020 10 2019 11 2018 68

2024 4

Aristolochic Acid Exposure via Dermal Contact or Inhalation of Herbal Powders: Evidence of Occupational Exposure in Herbalists with Urothelial Cancer

Chemical Research in Toxicology, v. 37, (6), June 2024, p. 873-877
Kwok, Hong Ching; Chan, Wan
Article

Combustion-Derived Pollutants Linked with Kidney Disease in Low-Lying Flood-Affected Areas in the Balkans

Environmental Science & Technology, v. 58, (26), July 2024, p. 11301-11308
Guo, Wanlin; Kwok, Hong Ching; Griffith, Stephen M.; Nagl, Stefan; Milovanovic, Dragan; Pavlovic, Miljana; Pavlovic, Nikola M.; Yu, Jianzhen; Dedon, Peter C.; Chan, Wan
Article

Effects of Heavy Metal Co-Exposure on the formation of DNA Adducts from Aristolochic Acid I: Implications for Balkan Endemic Nephropathy Development

Chemical Research in Toxicology, v. 37, (4), April 2024, p. 545-548
Au, Chun-Kit; Nagl, Stefan; Chan, Wan
Article

Positive Feedback Mechanism in Aristolochic Acid I Exposure-Induced Anemia and DNA Adduct Formation: Implications for Balkan Endemic Nephropathy

Journal of Agricultural and Food Chemistry, v. 72, (32), August 2024, p. 18155-18161
Ham, Yat Hing; Chin, Man Lung; Pan, Guanrui; Wang, Shuangshuang; Pavlovic, Nikola M.; Chan, Wan
Article

2023 5

Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy

Chemical Research in Toxicology, v. 36, (2), February 2023, p. 322-329
Au, Chun Kit; Ham, Yat Hing; Chan, Wan
Article

Effects of Diet on Aristolochic Acid-DNA Adduct Formation: Implications for Balkan Endemic Nephropathy Etiology

Chemical Research in Toxicology, v. 36, (3), March 2023, p. 438-445
Zhang, Jiayin; Chan, Chi Kong; Pavlović, Nikola M.; Chan, Wan
Article

Fabrication of a Simple and Efficient HPLC Reduction Column for Online Conversion of Aristolochic Acids to Aristolactams Prior to Sensitive Fluorescence Detection

Analytical Chemistry, v. 95, (33), August 2023, p. 12365-12372
Chin, Man Lung; Au, Chun Kit; Chan, Chi Kong; Jin, Long; Stošić, Živković Milena Z.; Zlatković, Đorđević Miljana R.; Zlatković, Dragan; Pavlović, Nikola M.; Chan, Wan
Article

Face Mask as a Versatile Sampling Device for the Assessment of Personal Exposure to 54 Toxic Compounds in Environmental Tobacco Smoke

Chemical Research in Toxicology, v. 36, (7), July 2023, p. 1140-1150
Guo, Wanlin; Yu, Jianzhen; Chan, Wan
Article

Occurrence and Stability of PCMX in Water Environments and Its Removal by Municipal Wastewater Treatment Processes

Journal of Hazardous Materials, v. 445, 5 March 2023, article number 130550
Au, Chun Kit; Chan, Kwan Kit; Chan, Wan; Zhang, Xiangru
Article

2022 5

DNA–Protein Cross-Links Formed by Reacting Lysine with Apurinic/Apyrimidinic Sites in DNA and Human Cells: Quantitative Analysis by Liquid Chromatography–Tandem Mass Spectrometry Coupled with Stable Isotope Dilution

Analytical Chemistry, v. 94, (2), January 2022, p. 803-810
Chan, Wan; Jin, Long
Article

LC-MS/MS Quantitation of Formaldehyde-Glutathione Conjugates as Biomarkers of Formaldehyde Exposure and Exposure-Induced Antioxidants: A New Look on an Old Topic

Chemical Research in Toxicology, v. 35, (5), April 2022, p. 858-866
Ham, Yat Hing; Pan, Guanrui; Chan, Ho Wai; Chan, Wan
Article

Polyurethane Foam Face Masks as a Dosimeter for Quantifying Personal Exposure to Airborne Volatile and Semi-Volatile Organic Compounds

Chemical Research in Toxicology, v. 35, (9), 19 September 2022, p. 1604-1613
Sun, Zhihan; Guo, Wanlin; Chan, Chi Kong; Jin, Long; Griffith, Stephen M.; Yu, Jianzhen; Chan, Wan
Article

Synergistic Interaction of Polycyclic Aromatic Hydrocarbons, Phthalate Esters, or Phenol on DNA Adduct Formation by Aristolochic Acid I: Insights into the Etiology of Balkan Endemic Nephropathy

Chemical Research in Toxicology, v. 35, (5), April 2022, p. 849-857
Zhang, Jiayin; Chan, Kwan Kit; Chan, Wan
Article

Wheatgrass (Triticum aestivum) as an Efficient Phytoremediation Plant for Aristolochic Acid-Contaminated Water and Arable Soil

ACS Agricultural Science and Technology, v. 2, (3), June 2022, p. 639-645
Kwok, Hong Ching; Chan, Wan
Article

2021 9

Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid i and Balkan Endemic Nephropathy

Environmental Science and Technology, v. 55, (13), July 2021, p. 9024-9032
Guo, Wanlin; Zhang, Jiayin; Sun, Zhihan; Orem, William H.; Tatu, Calin A.; Radulović, Niko S.; Milovanović, Dragan; Pavlović, Nikola M.; Chan, Wan
Article

Determination of Aristolochic Acids in Soil, Water, and Herbal Plants in Medicinal Plant Cultivation Areas: An Emerging Environmental Contaminant Worth concerning

ACS Agricultural Science and Technology, v. 1, (5), September 2021, p. 522-528
Chan, Chi Kong; Xiong, Lei; Pavlović, Nikola M.; Chan, Wan
Article

Fabric Masks as a Personal Dosimeter for Quantifying Exposure to Airborne Polycyclic Aromatic Hydrocarbons

Environmental Science & Technology, v. 55, (8), April 2021, p. 5128-5135
Chan, Wan; Jin, Long; Sun, Zhihan; Griffith, Stephen M.; Yu, Jianzhen
Article

Formation, Stability, and Antioxidative Properties of 2-Methylthioproline and 2-Methylthioprolineglycine in Grape Wines

ACS Food Science & Technology, v. 1, (5), June 2021, p. 892-898
Chan, Wan; Zhao, Yao; Chan, Kwan Kit
Article

On the Flip Side of Mask Wearing: Increased Exposure to Volatile Organic Compounds and a Risk-Reducing Solution

Environmental Science and Technology, v. 55, (20), October 2021, p. 14095-14104
Jin, Long; Griffith, Stephen M.; Sun, Zhihan; Yu, Jianzhen; Chan, Wan
Article

Polyurethane-Based Face Mask as a Sampling Device for Environmental Tobacco Smoke

Analytical Chemistry, v. 93, (41), 5 October 2021, p. 13912-13918
Chan, Wan; Guo, Wanlin; Yu, Jianzhen
Article

Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid Nephropathy

Chemical Research in Toxicology, v. 24, (8), August 2021, p. 1903-1909
Chan, Wan; Ham, Yat Hing
Article

Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography-Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure

Chemical Research in Toxicology, v. 34, (1), January 2021, p. 144-153
Chan, Chi Kong; Chan, Kwan Kit; Liu, Ning; Chan, Wan
Article

Quantitation of γ-Glutamylcysteine-Formaldehyde Conjugate in Formaldehyde- and Oxidative Stress-Exposed Cells by Liquid Chromatography-Tandem Mass Spectrometry

Chemical Research in Toxicology, v. 34, (7), July 2021, p. 1782-1789
Zhao, Yao; Chan, Wan
Article

2020 10

Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry

Journal of Mass Spectrometry, 31 August 2020
Chan, Chi Kong; Pan, Guanrui; Chan, Wan
Article

Determination of Aristolochic Acids in Vegetables: Nephrotoxic and Carcinogenic Environmental Pollutants Contaminating a Broad Swath of the Food Supply and Driving Incidence of Balkan Endemic Nephropathy

Chemical Research in Toxicology, v. 33, (9), 31 July 2020, p. 2446-2454
Au, Chun Kit; Zhang, Jiayin; Chan, Chi Kong; Li, Cui; Liu, Guorui; Pavlović, Nikola M.; Yao, Jing; Chan, Wan
Article

Identifying Cysteine, N‑Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway

Chemical Research in Toxicology, v. 33, (6), June 2020, p. 1374-1381
Zhang, Jiayin; Chan, Chi Kong; Ham, Yat Hing; Chan, Wan
Article

LC-MS/MS Coupled with a Stable-Isotope Dilution Method for the Quantitation of Thioproline-Glycine: A Novel Metabolite in Formaldehyde- and Oxidative Stress-Exposed Cells

Chemical Research in Toxicology, v. 33, (7), July 2020, p. 1989-1996
Pan, Guanrui; Ham, Yat Hing; Chan, Ho Wai; Yao, Jing; Chan, Wan
Article

Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy

Environmental Science and Technology, v. 54, (3), February 2020, p. 1554-1561
Tung, Ka Ki; Chan, Chi Kong; Zhao, Yao; Chan, Kwan Kit; Liu, Guorui; Pavlovic, Nikola M.; Chan, Wan
Article

Proteomic Analysis of Thioproline Misincorporation in Escherichia coli

Journal of Proteomics, v. 210, January 2020, article number 103541
Liu, Jingjing; Hao, Chunlin; Wu, Long; Madej, Dominik; Chan, Wan; Lam, Hei Ning
Article

Proteomics Study of DNA-Protein Crosslinks in Methylmethanesulfonate and Fe²⁺-EDTA-Exposed Human Cells

Chemical Research in Toxicology, v. 33, (11), November 2020, p. 2739-2744
Ham, Yat Hing; Chan, Kwan Kit; Madej, Dominik; Lam, Hei Ning; Chan, Wan
Article

Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism

Chemical Research in Toxicology, v. 33, (6), June 2020, p. 1323-1327
Au, Chun Kit; Chan, Chi Kong; Tung, Ka Ki; Zhang, Jiayin; Chan, Wan
Article

Remediation of aristolochic acid-contaminated soil by an effective advanced oxidation process

Science of the Total Environment, v. 720, June 2020, article number 137528
Chan, Chi Kong; Tung, Ka Ki; Pavlović, Nikola M; Chan, Wan
Article

Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability

Chemical Research in Toxicology, v. 33, (7), July 2020, p. 1815-1821
Ham, Yat Hing; Chan, Kwan Kit; Chan, Wan
Article

2019 11

Aristolochic acids: Newly identified exposure pathways of this class of environmental and food-borne contaminants and its potential link to chronic kidney diseases

Toxics, v. 7, (1), March 2019, article number 14
Chan, Chi Kong; Liu, Yushuo; Nikola, M.Pavlović; Chan, Wan
Article

Development of a Novel Liquid Chromatography-Tandem Mass Spectrometric Method for Aristolochic Acids Detection: Application in Food and Agricultural Soil Analyses

Food Chemistry, v. 289, August 2019, p. 673-679
Chan, Chi Kong; Pavlović, Nikola M.; Chan, Wan
Article

Evaluating the Performance of Sample Preparation Methods for Ultra-performance Liquid Chromatography/mass Spectrometry Based Serum Metabonomics

Rapid Communications in Mass Spectrometry, v. 33, (6), March 2019, p. 561-568
Chan, Wan; Zhao, Yao; Zhang, Jiayin
Article

Gas-Phase Fragmentation Reactions of Protonated Cystine Using High-Resolution Tandem Mass Spectrometry

Molecules, v. 24, (4), February 2019, article number 747
Zhang, Pengwei; Chan, Wan; Ang, Irene L.; Wei, Rui; Lam, Melody M. T.; Lei, Kate M. K.; Poon, Terence C. W.
Article

Investigation of the Chemical Structure and Formation Mechanism of Polydopamine From Self-assembly of Dopamine by Liquid Chromatography/mass Spectrometry Coupled With Isotope-labelling Techniques

Rapid Communications in Mass Spectrometry, v. 33, (5), March 2019, p. 429-436
Chan, Wan
Article

Liquid chromatography–tandem mass spectrometry analysis of aristolochic acids in soil samples collected from Serbia: Link to Balkan endemic nephropathy

Rapid Communications in Mass Spectrometry, August 2019
Chan, Chi Kong; Chan, Kwan Kit; Pavlović, N.M.; Chan, Wan
Article

Quantification of a Novel DNA–Protein Cross-Link Product Formed by Reacting Apurinic/Apyrimidinic Sites in DNA with Cysteine Residues in Protein by Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method

Analytical Chemistry, v. 91, (8), 16 April 2019, p. 4987-4994
Chan, Wan; Ham, Yat Hing; Jin, Long; Chan, Ho Wai; Wong, Yee Lam; Chan, Chi Kong; Chung, Pui Yin
Article

Quantitation of DNA Adducts in Target and Nontarget Organs of Aristolochic Acid I-Exposed Rats: Correlating DNA Adduct Levels with Organotropic Activities

Chemical Research in Toxicology, v. 32, (3), March 2019, p. 397-399
Liu, Yushuo; Chan, Chi Kong; Jin, Long; Wong, Sum Kok; Chan, Wan
Article

Quantitation of N6-Formyl-lysine Adduct Following Aristolochic Acid Exposure in Cells and Rat Tissues by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope-Dilution Method

Chemical Research in Toxicology, v. 32, (10), October 2019, p. 2086-2094
Zhao, Yao; Chan, Chi Kong; Chan, Kwan Kit; Chan, Wan
Article

Revisiting Fragmentation Reactions of Protonated alpha-Amino Acids by High-Resolution Electrospray lonization Tandem Mass Spectrometry with Collision-Induced Dissociation

Scientific Reports, v. 9, April 2019, article number 6453
Zhang, Pengwei; Chan, Wan; Ang, Irene L.; Wei, Rui; Lam, Melody M. T.; Lei, Kate M. K.; Poon, Terence C. W.
Article

Transcriptomic Responses of the Marine Cyanobacterium Prochlorococcus to Viral Lysis Products

Environmental Microbiology, v. 21, (6), June 2019, p. 2015-2028
Fang, Xiaoting; Liu, Yaxin; Zhao, Yao; Chen, Yue; Liu, Riyue; Qin, Qi-Long; Li, Gang; Zhang, Yu-Zhong; Chan, Wan; Hess, Wolfgang R.; Zeng, Qinglu
Article

2018 5

Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake

Journal of Agricultural and Food Chemistry, v. 66, (43), October 2018, p. 11468-11476
Li, Weiwei; Chan, Chi Kong; Liu, Yushuo; Yao, Jing; Mitic, Branka; Kostic, Emina N.; Milosavljevic, Biljana; Davinic, Ivana; Orem, William H.; Tatu, Calin A.; Dedon, Peter C.; Pavlovic, Nikola M.; Chan, Wan
Article

Cooking Methods Employing Natural Anti-oxidant Food Additives Effectively Reduced Concentration of Nephrotoxic and Carcinogenic Aristolochic Acids in Contaminated Food Grains

Food Chemistry, v 264, October 2018, p. 270-276
Li, Weiwei; Chan, Chi Kong; Wong, Yee Lam; Chan, Kwan Kit Jason; Chan, Ho Wai; Chan, Wan
Article

Etiology of Balkan Endemic Nephropathy: An Update on Aristolochic Acids Exposure Mechanisms

Chemical Research in Toxicology, v. 31, (11), November 2018, p. 1109-1110
Chan, Chi Kong; Liu, Yushuo; Pavlovic, Nikola M.; Chan, Wan
Article

Quantification of DNA and Protein Adducts of 1‑Nitropyrene: Significantly Higher Levels of Protein than DNA Adducts in the Internal Organs of 1‑Nitropyrene Exposed Rats

Chemical Research in Toxicology, v. 31, (8), Aug 2018, p. 680-687
Chan, Wan; Wong, Sum Kok; Li, Weiwei
Article

Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in Vitamin K Biosynthesis

ChemBioChem, v. 19, (14), July 2018, p. 1514-1522
Qin, Mingming; Song, Haigang; Dai, Xin; Chan, Chi Kong; Chan, Wan; Guo, Zhihong
Article

2017 4

Determination of 2-alkylcyclobutanones in Ultraviolet Light-irradiated Fatty Acids, Triglycerides, Corn oil, and Pork Samples: Identifying a New Source of 2-alkylcyclobutanones

Food Chemistry, v. 217, February 2017, p. 352-359
Meng, Xiangpeng; Chan, Wan
Article

Development of a QuEChERS-Based Method for Determination of Carcinogenic 2-Nitrofluorene and 1-Nitropyrene in Rice Grains and Vegetables: A Comparative Study with Benzo[a]pyrene

Journal of Agricultural and Food Chemistry, v. 65, (9), 8 Mar 2017, p. 1992-1999
Deng, Kailin; Chan, Simon Wan
Article

Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil

Journal of Agricultural and Food Chemistry, v. 65, (21), May 2017, p. 4255-4261
Wang, Yinan; Chan, Kwan Kit Jason; Chan, Wan
Article

A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis

Song, Haigang; Qin, Mingming; Chen, Dong; Dai, Xin; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong
Conference paper

2016 12

A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis

Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong
Article

An Investigation on the Chemical Structure of Nitrogen and Sulfur Codoped Carbon Nanoparticles by Ultra-performance Liquid Chromatography-tandem Mass Spectrometry

Analytical and Bioanalytical Chemistry, v. 408, (19), July 2016, p. 5347-5357
Hu, Qin; Meng, Xiangpeng; Chan, Wan
Article

Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography -Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples

Journal of Agricultural and Food Chemistry, v. 64, (13), April 2016, p. 2802-2808
Wang, Yinan; Chan, Wan
Article

Determination of 2-alkylcyclobutanones by Combining Precolumn Derivatization with 1-naphthalenyl hydrazine and Ultra-performance Liquid Chromatography with Fluorescence Detection

Analytical and Bioanalytical Chemistry, v. 408, (14), May 2016, p. 3707-3714
Meng, Xiangpeng; Tong, Tong; Wang, Lianrong; Liu, Hanxia; Chan, Wan
Article

Determination of DNA Adducts by Combining Acid-Catalyzed Hydrolysis and Chromatographic Analysis of the Carcinogens-Modified Nucleobases

Analytical and Bioanalytical Chemistry, v. 408, (3), January 2016, p. 953-961
Leung, Ming Kit; Deng, Kailin; Wong, Tin Yan; Chan, Wan
Article

Elucidating the structure of carbon nanoparticles by ultra-performance liquid chromatography coupled with electrospray ionisation quadrupole time-of-flight tandem mass spectrometry

Analytica Chimica Acta, v. 911, March 2016, p. 100-107
Hu, Qin; Meng, Xiangpeng; Choi, Martin M. F.; Gong, Xiaojuan; Chan, Wan
Article

Facile Formation of a DNA Adduct of Semicarbazide on Reaction with Apurinic/Apyrimidinic Sites in DNA

Chemical Research in Toxicology, v. 29, (5), May 2016, p. 834-840
Wang, Yinan; Chan, Ho Wai; Chan, Wan
Article

Identification of Protein Thiazolidination as a Novel Molecular Signature for Oxidative Stress and Formaldehyde Exposure

Chemical Research in Toxicology, v. 29, (11), November 2016, p. 1865-1871
Liu, Jingjing; Chan, Kwan Kit Jason; Chan, Wan
Article

Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy

Journal of Agricultural and Food Chemistry, v. 64, (29), July 2016, p. 5928-5934
Chan, Wan; Pavlović, Nikola M.; Li, Weiwei; Chan, Chi Kong; Liu, Jingjing; Deng, Kailin; Wang, Yinan; Milosavljević, Biljana; Kostić, Emina N.
Article

Quantitation of the DNA Adduct of Semicarbazide in Organs of Semicarbazide-Treated Rats by Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry: A Comparative Study with the RNA Adduct

Chemical Research in Toxicology, v. 29, (9), September 2016, p. 1560-1564
Wang, Yinan; Wong, Tin Yan; Chan, Simon Wan
Article

Quantitation of Thioprolines in Grape Wine by Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry

Journal of Agricultural and Food Chemistry, v. 64, (6), February 2016, p. 1361-1366
Liu, Jingjing; Meng, Xiangpeng; Chan, Wan
Article

Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water

Journal of Agricultural and Food Chemistry, v. 64, (1), January 2016, p. 107-112
Li, Weiwei; Hu, Qin; Chan, Wan
Article

2015 9

Combination of Precolumn Nitro-reduction and Ultraperformance Liquid Chromatography with Fluorescence Detection for the Sensitive Quantification of 1-Nitronaphthalene, 2-Nitrofluorene, and 1-Nitropyrene in Meat Products

Journal of Agricultural and Food Chemistry, v. 63, (12), April 2015, p. 3161-3167
Deng, Kailin; Wong, Tin Yan; Wang, Yinan; Leung, Elvis Ming Kit; Chan, Simon Wan
Article

Comparison of DNA and RNA adduct formation: Significantly higher levels of RNA than DNA modifications in the internal organs of aristolochic acids-dosed rats

Chemical Research in Toxicology, v. 28, (2), February 2015, p. 248-255
Leung, Elvis Ming Kit; Chan, Simon Wan
Article

Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry

Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan
Article

Mass spectrometric and spectrofluorometric studies of the interaction of aristolochic acids with proteins

Scientific Reports, v. 5, October 2015, article number 15192
Li, Weiwei; Hu, Qin; Chan, Wan
Article

Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin

Analytical Chemistry, v. 87, (15), August 2015, p. 7958-7963
Li, Yuanjiao; Liu, Jingjing; Wang, Yajie; Chan, Ho Wai; Wang, Lianrong; Chan, Wan
Article

Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (35), September 2015, p. E4845-E4853
Jumpathong, Watthanachai; Chan, Wan; Taghizadeh, Koli; Babu, I. Ramesh; Dedon, Peter C.
Article

Quantification of Aristolochic Acid-RNA Adducts in the Urine of Aristolochic Acid-Treated Rats by Liquid Chromatography-Tandem Mass Spectrometry

Chemical Research in Toxicology, v. 28, (4), April 2015, p. 567-569
Leung, Elvis M.K.; Chan, Wan
Article

Quantification of Thiazolidine-4-carboxylic Acid in Toxicant-Exposed Cells by Isotope-Dilution Liquid Chromatography-Mass Spectrometry Reveals an Intrinsic Antagonistic Response to Oxidative Stress-Induced Toxicity

Chemical Research in Toxicology, v. 28, (3), March 2015, p. 394-400
Liu, Jingjing; Chan, Wan
Article

Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB

Scientific Reports, v. 5, July 2015, article number 12368
He, Wei; Huang, Teng; Tang, You; Liu, Yanhua; Wu, Xiaolin; Chen, Si; Chan, Wan; Wang, Yajie; Liu, Xiaoyun; Chen, Shi; Wang, Lianrong
Article

2014 4

A novel reversed-phase HPLC method for the determination of urinary creatinine by pre-column derivatization with ethyl chloroformate: comparative studies with the standard Jaffé , and isotope-dilution mass spectrometric assays

Analytical and Bioanalytical Chemistry, v. 406, (6), February 2014, p. 1807-1812
Leung, Elvis Ming Kit; Chan, Wan
Article

Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection

Journal of Agricultural and Food Chemistry, v. 62, (25), June 2014, p. 5859-5864
Wang, Yinan; Chan, Wan
Article

Noninvasive measurement of aristolochic acid-DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectrometry: Evidence for DNA repair by nucleotide-excision repair mechanisms

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, v. 766, August 2014, p. 1-6
Leung, Elvis Ming Kit; Chan, Simon Wan
Article

Rapid identification of gamma-irradiated food by direct solvent extraction and liquid chromatography-tandem mass spectrometric analysis of 2-dodecylcyclobutanone: Application in surveillance of irradiated food

Food Chemistry, v. 161, October 2014, p. 312-316
Chan, Simon Wan; Ye, Yuran; Leung, Elvis Ming Kit
Article

2013 6

Analysis of 2-Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2-Alkylcyclobutanones for Irradiated Food Identification

Journal of Agricultural and Food Chemistry, v. 61, (41), October 2013, p. 9950-9954
Leung, Elvis Ming Kit; Tang, Phyllis Nya Yang; Ye, Yuran; Chan, Wan
Article

Capillary electrophoretic study of amine/carboxylic acid-functionalized carbon nanodots

Journal of Chromatography A, v. 1304, August 2013, p. 234-240
Hu, Qin; Paau, Man Chin; Zhang, Yan; Chan, Wan; Gong, Xiaojuan; Zhang, Lei; Choi, Martin M.F.
Article

Combination of pentafluorophenylhydrazine derivatization and isotope dilution LC-MS/MS techniques for the quantification of apurinic/apyrimidinic sites in cellular DNA

Analytical and Bioanalytical Chemistry, v. 405, (12), 2013, p. 4059-4066
Li, Jie; Leung, Elvis Ming Kit; Choi, Martin Ming Fat; Chan, Wan
Article

Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, v. 74, February 2013, p. 156-161
Li, Jie; Chan, Wan
Article

Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometric Analysis of 2-Alkylcyclobutanones in Irradiated Chicken by Precolumn Derivatization with Hydroxylamine

Journal of Agricultural and Food Chemistry, v. 61, (24), June 2013, p. 5758-5763
Ye, Yuran; Liu, Hanxia; Horvatovich, Peter; Chan, Wan
Article

Probing Histidine-Stabilized Gold Nanoclusters Product by High-Performance Liquid Chromatography and Mass Spectrometry

Journal of Physical Chemistry C, v. 117, (36), September 2013, p. 18697-18708
Zhang, Yan; Hu, Qin; Paau, Man Chin; Xie, Shunping; Gao, Pengfei; Chan, Wan; Choi, Martin Ming Fat
Article

2012 2

High-performance liquid chromatographic analysis of as-synthesised N,N '-dimethylformamide-stabilised gold nanoclusters product

Nanoscale, v. 4, (17), 2012, p. 5325-5332
Xie, Shunping; Paau, Man Chin; Zhang, Yan; Shuang, Shaomin; Chan, Wan; Choi, Martin M.F.
Article

In situ analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra

Journal of the American Chemical Society, v. 134, (43), 2012, p. 18053-18064
Lim, K.S.; Cui, L.; Taghizadeh, K.; Wishnok, J.S.; Chan, Wan; Demott, M.S.; Babu, I.R.; Tannenbaum, S.R.; Dedon, P.C.
Article

2011 2

DNA phosphorothioation is widespread and quantized in bacterial genomes

Proceedings of the National Academy of Sciences of the United States of America, v. 108, (7), 2011, p. 2963-2968
Wang, Lianrong; Chen, Shi; Vergin, Kevin, L.; Giovannoni, Stephen J.; Chan, Simon Wan; Demott, Michael S.; Taghizadeh, Koli; Cordero, Otto X.; Cutler, Michael; Timberlake, Sonia; Alm, Eric J.; Polz, Martin F.; Pinhassi, Jarone; Deng, Zixin; Dedon, Peter C.
Article

Metabolomics Analysis of the Responses to Partial Hepatectomy in Hepatocellular Carcinoma Patients

American Journal of Analytical Chemistry, v. 2, 2011, p. 142-151
Chan, Wan; Lin, Shuhai; Sun, Stella; Liu, Hongde; Cai, Zongwei; Luk, John M.
Article

2010 3

Liquid chromatography/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: the plasma metabolome

Rapid Communications in Mass Spectrometry, v. 24, (9), 2010, p. 1312-1318
Lin, Shuhai; Chan, Wan; Li, Jinhua; Cai, Zongwei
Article

Quantification of the 2-Deoxyribonolactone and Nucleoside 5′-Aldehyde Products of 2-Deoxyribose Oxidation in DNA and Cells by Isotope-Dilution Gas Chromatography Mass Spectrometry: Differential Effects of γ-Radiation and Fe²⁺−EDTA

Journal of the American Chemical Society, v. 132, (17), 2010, p. 6145-6153
Chan, Wan; Chen, Bingzi; Wang, Lianrong; Taghizadeh, Koli; Demott, Michael S.; Dedon, Peter C.
Article

The biological and metabolic fates of endogenous DNA damage products

Journal of Nucleic Acids, v. 2010, 2010, article number 929047
Chan, Simon Wan; Dedon, Peter C.
Article

2009 5

A Method to Enhance a 1 Ions and Application for Peptide Sequencing and Protein Identification

Journal of the American Society for Mass Spectrometry, v. 20, (6), 2009, p. 1214-1223
Liu, N.; Chan, Wan; Lee, K.C.; Cai, Z.
Article

A new approach for the sensitive determination of DNA adduct of aristolochic acid II by using high-performance liquid chromatography with fluorescence detection

Journal of chromatography. B, v. 877, (10), 2009, p. 848-852
Chan, Wan; Poon, W.T.; Chan, Y.W.; Wan, K.Y.; Cai, Z.
Article

Determination of aristolochic acid I in rat urine and plasma by high-performance liquid chromatography with fluorescence detection

Journal of chromatography. B, v. 877, (10), 2009, p. 995-999
Yue, H.; Chan, Wan; Guo, L.; Cai, Z.
Article

On-line capillary electrophoresis-electrospray ionization mass spectrometry analysis of urinary porphyrins

Electrophoresis, v. 30, 2009, p. 1790-1797
Li, JH; Chan, Wan; Cai, ZW
Article

Recent progress in quantitative analysis of DNA adducts of nephrotoxin aristolochic acid

Science in China. Series B, Chemistry, v. 52, (10), 2009, p. 1576-1582
Yue, H.; Chan, Wan; Yu, K.; Guo, L.; Liu, N.; Liu, H.; Cai, Z.
Article

2008 8

Aristolochic acid induced changes in the metabolic profile of rat urine

Journal of pharmaceutical and biomedical analysis, v. 46, (4), 2008, p. 757-762
Chan, Wan; Cai, Z.
Article

Characterization of the DNA adducts induced by aristolochic acids in oligonucleotides by electrospray ionization tandem mass spectrometry

Rapid communications in mass spectrometry, v. 22, (23), 2008, p. 3735-3742
Chan, Wan; Yue, H.; Wong, R.N.S.; Cai, Z.
Article

High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen

Talanta, v. 75, (4), 2008, p. 1002-1007
Cui, L.; Chan, Wan; Wu, J.L.; Jiang, Z.H.; Chan, K.; Cai, Z.
Article

Identification of four urea adducts of Andrographolide in human

Drug Metab. Lett., v. 2, 2008, p. 261-268
Cui, L.; Chan, Wan; Qiu, F.; Cai, ZW; Yao, Z.
Article

Liquid chromatography/mass spectrometry for metabonomics investigation of the biochemical effects induced by aristolochic acid in rats: The use of information-dependent acquisition for biomarker identification

Rapid communications in mass spectrometry, v. 22, (6), 2008, p. 873-880
Chan, Wan; Lee, K.C.; Liu, N.; Wong, R.N.S.; Liu, H.; Cai, Z.
Article

Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells

Proteomics, v. 8, 2008, p. 1851-1858
Liu, N.; Song, WJ; Wang, P.; Lee, KC; Chan, Wan; Chen, HL; Cai, ZW
Article

Quantification of Aristolochic Acid-Derived DNA Adducts in Rat Kidney and Liver by Using Liquid Chromatography-Electrospray Ionization Mass Spectrometry

Mutat. Res, v. 646, 2008, p. 17-24
Chan, Wan; Yue, H.; Poon, WY; Chan,Y-W; Schmitz, Oliver J.; Kwong, Daniel WJ; Wong, Ricky NS; Cai, ZW
Article

Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry in negative ion mode

Rapid communications in mass spectrometry, v. 22, (18), 2008, p. 2825-2834
Lee, K.C.; Chan, Wan; Liang, Z.; Liu, N.; Zhao, Z.; Lee, A.W.M.; Cai, Z.
Article

2007 4

A sensitivity enhanced high-performance liquid chromatography fluorescence method for the detection of nephrotoxic and carcinogenic aristolochic acid in herbal medicines

Journal of chromatography. A, v. 1164, (1-2), 2007, p. 113-119
Chan, Wan; Lee, K.C.; Liu, N.; Cai, ZW
Article

Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats

Drug Metab. Dispos, v. 35, 2007, p. 866-874
Chan, Wan; Luo, HB; Zheng, YF; Cheng, YK; Cai, ZW
Article

Liquid Chromatography-Tandem Mass Spectrometry Analysis of the DNA Adducts of Aristolochic Acids

Journal of the American Society for Mass Spectrometry, v. 18, (4), 2007, p. 642-650
Chan, Wan; Zheng, Y.; Cai, Z.
Article

Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry

Analytical and bioanalytical chemistry, v. 387, (6), 2007, p. 2219-2225
Ma, W.T.; Chan, Wan; Steinbach, K.; Cai, Z.
Conference paper

2006 3

Determination of glucosinolates in traditional Chinese herbs by high-performance liquid chromatography and electrospray ionization mass spectrometry

Analytical and bioanalytical chemistry, v. 386, (7-8), 2006, p. 2225-2232
Lee, K.C.; Cheuk, M.W.; Chan, Wan; Lee, A.W.M.; Zhao, Z.Z.; Jiang, Z.H.; Cai, Z.
Article

Differentiation of herbs linked to "Chinese herb nephropathy" from the liquid chromatographic determination of aristolochic acids

Analytica Chimica Acta, v. 576, (1), 2006, p. 112-116
Chan, Wan; Hui, K.M.; Poon, W.T.; Lee, K.C.; Cai, Z.
Article

Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, v. 20, (11), 2006, p. 1755-1760
Chan, Wan; Cui, L.; Xu, G.; Cai, Z.
Article

2005 1

Identification of components in traditional Chinese medicinal products using LC-MS

Encyclopedia of Mass Spectrometry (V8), Pergamon Pr, 2005, article number: Else_EMASV008_93
Chan, Wan; Cai, ZW
Article

Article 4

Aristolochic Acid Exposure via Dermal Contact or Inhalation of Herbal Powders: Evidence of Occupational Exposure in Herbalists with Urothelial Cancer

Chemical Research in Toxicology, v. 37, (6), June 2024, p. 873-877
Kwok, Hong Ching; Chan, Wan

Combustion-Derived Pollutants Linked with Kidney Disease in Low-Lying Flood-Affected Areas in the Balkans

Environmental Science & Technology, v. 58, (26), July 2024, p. 11301-11308
Guo, Wanlin; Kwok, Hong Ching; Griffith, Stephen M.; Nagl, Stefan; Milovanovic, Dragan; Pavlovic, Miljana; Pavlovic, Nikola M.; Yu, Jianzhen; Dedon, Peter C.; Chan, Wan

Effects of Heavy Metal Co-Exposure on the formation of DNA Adducts from Aristolochic Acid I: Implications for Balkan Endemic Nephropathy Development

Chemical Research in Toxicology, v. 37, (4), April 2024, p. 545-548
Au, Chun-Kit; Nagl, Stefan; Chan, Wan

Positive Feedback Mechanism in Aristolochic Acid I Exposure-Induced Anemia and DNA Adduct Formation: Implications for Balkan Endemic Nephropathy

Journal of Agricultural and Food Chemistry, v. 72, (32), August 2024, p. 18155-18161
Ham, Yat Hing; Chin, Man Lung; Pan, Guanrui; Wang, Shuangshuang; Pavlovic, Nikola M.; Chan, Wan

Article 5

Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy

Chemical Research in Toxicology, v. 36, (2), February 2023, p. 322-329
Au, Chun Kit; Ham, Yat Hing; Chan, Wan

Effects of Diet on Aristolochic Acid-DNA Adduct Formation: Implications for Balkan Endemic Nephropathy Etiology

Chemical Research in Toxicology, v. 36, (3), March 2023, p. 438-445
Zhang, Jiayin; Chan, Chi Kong; Pavlović, Nikola M.; Chan, Wan

Fabrication of a Simple and Efficient HPLC Reduction Column for Online Conversion of Aristolochic Acids to Aristolactams Prior to Sensitive Fluorescence Detection

Analytical Chemistry, v. 95, (33), August 2023, p. 12365-12372
Chin, Man Lung; Au, Chun Kit; Chan, Chi Kong; Jin, Long; Stošić, Živković Milena Z.; Zlatković, Đorđević Miljana R.; Zlatković, Dragan; Pavlović, Nikola M.; Chan, Wan

Face Mask as a Versatile Sampling Device for the Assessment of Personal Exposure to 54 Toxic Compounds in Environmental Tobacco Smoke

Chemical Research in Toxicology, v. 36, (7), July 2023, p. 1140-1150
Guo, Wanlin; Yu, Jianzhen; Chan, Wan

Occurrence and Stability of PCMX in Water Environments and Its Removal by Municipal Wastewater Treatment Processes

Journal of Hazardous Materials, v. 445, 5 March 2023, article number 130550
Au, Chun Kit; Chan, Kwan Kit; Chan, Wan; Zhang, Xiangru

Article 5

DNA–Protein Cross-Links Formed by Reacting Lysine with Apurinic/Apyrimidinic Sites in DNA and Human Cells: Quantitative Analysis by Liquid Chromatography–Tandem Mass Spectrometry Coupled with Stable Isotope Dilution

Analytical Chemistry, v. 94, (2), January 2022, p. 803-810
Chan, Wan; Jin, Long

LC-MS/MS Quantitation of Formaldehyde-Glutathione Conjugates as Biomarkers of Formaldehyde Exposure and Exposure-Induced Antioxidants: A New Look on an Old Topic

Chemical Research in Toxicology, v. 35, (5), April 2022, p. 858-866
Ham, Yat Hing; Pan, Guanrui; Chan, Ho Wai; Chan, Wan

Polyurethane Foam Face Masks as a Dosimeter for Quantifying Personal Exposure to Airborne Volatile and Semi-Volatile Organic Compounds

Chemical Research in Toxicology, v. 35, (9), 19 September 2022, p. 1604-1613
Sun, Zhihan; Guo, Wanlin; Chan, Chi Kong; Jin, Long; Griffith, Stephen M.; Yu, Jianzhen; Chan, Wan

Synergistic Interaction of Polycyclic Aromatic Hydrocarbons, Phthalate Esters, or Phenol on DNA Adduct Formation by Aristolochic Acid I: Insights into the Etiology of Balkan Endemic Nephropathy

Chemical Research in Toxicology, v. 35, (5), April 2022, p. 849-857
Zhang, Jiayin; Chan, Kwan Kit; Chan, Wan

Wheatgrass (Triticum aestivum) as an Efficient Phytoremediation Plant for Aristolochic Acid-Contaminated Water and Arable Soil

ACS Agricultural Science and Technology, v. 2, (3), June 2022, p. 639-645
Kwok, Hong Ching; Chan, Wan

Article 9

Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid i and Balkan Endemic Nephropathy

Environmental Science and Technology, v. 55, (13), July 2021, p. 9024-9032
Guo, Wanlin; Zhang, Jiayin; Sun, Zhihan; Orem, William H.; Tatu, Calin A.; Radulović, Niko S.; Milovanović, Dragan; Pavlović, Nikola M.; Chan, Wan

Determination of Aristolochic Acids in Soil, Water, and Herbal Plants in Medicinal Plant Cultivation Areas: An Emerging Environmental Contaminant Worth concerning

ACS Agricultural Science and Technology, v. 1, (5), September 2021, p. 522-528
Chan, Chi Kong; Xiong, Lei; Pavlović, Nikola M.; Chan, Wan

Fabric Masks as a Personal Dosimeter for Quantifying Exposure to Airborne Polycyclic Aromatic Hydrocarbons

Environmental Science & Technology, v. 55, (8), April 2021, p. 5128-5135
Chan, Wan; Jin, Long; Sun, Zhihan; Griffith, Stephen M.; Yu, Jianzhen

Formation, Stability, and Antioxidative Properties of 2-Methylthioproline and 2-Methylthioprolineglycine in Grape Wines

ACS Food Science & Technology, v. 1, (5), June 2021, p. 892-898
Chan, Wan; Zhao, Yao; Chan, Kwan Kit

On the Flip Side of Mask Wearing: Increased Exposure to Volatile Organic Compounds and a Risk-Reducing Solution

Environmental Science and Technology, v. 55, (20), October 2021, p. 14095-14104
Jin, Long; Griffith, Stephen M.; Sun, Zhihan; Yu, Jianzhen; Chan, Wan

Polyurethane-Based Face Mask as a Sampling Device for Environmental Tobacco Smoke

Analytical Chemistry, v. 93, (41), 5 October 2021, p. 13912-13918
Chan, Wan; Guo, Wanlin; Yu, Jianzhen

Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid Nephropathy

Chemical Research in Toxicology, v. 24, (8), August 2021, p. 1903-1909
Chan, Wan; Ham, Yat Hing

Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography-Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure

Chemical Research in Toxicology, v. 34, (1), January 2021, p. 144-153
Chan, Chi Kong; Chan, Kwan Kit; Liu, Ning; Chan, Wan

Quantitation of γ-Glutamylcysteine-Formaldehyde Conjugate in Formaldehyde- and Oxidative Stress-Exposed Cells by Liquid Chromatography-Tandem Mass Spectrometry

Chemical Research in Toxicology, v. 34, (7), July 2021, p. 1782-1789
Zhao, Yao; Chan, Wan

Article 10

Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry

Journal of Mass Spectrometry, 31 August 2020
Chan, Chi Kong; Pan, Guanrui; Chan, Wan

Determination of Aristolochic Acids in Vegetables: Nephrotoxic and Carcinogenic Environmental Pollutants Contaminating a Broad Swath of the Food Supply and Driving Incidence of Balkan Endemic Nephropathy

Chemical Research in Toxicology, v. 33, (9), 31 July 2020, p. 2446-2454
Au, Chun Kit; Zhang, Jiayin; Chan, Chi Kong; Li, Cui; Liu, Guorui; Pavlović, Nikola M.; Yao, Jing; Chan, Wan

Identifying Cysteine, N‑Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway

Chemical Research in Toxicology, v. 33, (6), June 2020, p. 1374-1381
Zhang, Jiayin; Chan, Chi Kong; Ham, Yat Hing; Chan, Wan

LC-MS/MS Coupled with a Stable-Isotope Dilution Method for the Quantitation of Thioproline-Glycine: A Novel Metabolite in Formaldehyde- and Oxidative Stress-Exposed Cells

Chemical Research in Toxicology, v. 33, (7), July 2020, p. 1989-1996
Pan, Guanrui; Ham, Yat Hing; Chan, Ho Wai; Yao, Jing; Chan, Wan

Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy

Environmental Science and Technology, v. 54, (3), February 2020, p. 1554-1561
Tung, Ka Ki; Chan, Chi Kong; Zhao, Yao; Chan, Kwan Kit; Liu, Guorui; Pavlovic, Nikola M.; Chan, Wan

Proteomic Analysis of Thioproline Misincorporation in Escherichia coli

Journal of Proteomics, v. 210, January 2020, article number 103541
Liu, Jingjing; Hao, Chunlin; Wu, Long; Madej, Dominik; Chan, Wan; Lam, Hei Ning

Proteomics Study of DNA-Protein Crosslinks in Methylmethanesulfonate and Fe²⁺-EDTA-Exposed Human Cells

Chemical Research in Toxicology, v. 33, (11), November 2020, p. 2739-2744
Ham, Yat Hing; Chan, Kwan Kit; Madej, Dominik; Lam, Hei Ning; Chan, Wan

Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism

Chemical Research in Toxicology, v. 33, (6), June 2020, p. 1323-1327
Au, Chun Kit; Chan, Chi Kong; Tung, Ka Ki; Zhang, Jiayin; Chan, Wan

Remediation of aristolochic acid-contaminated soil by an effective advanced oxidation process

Science of the Total Environment, v. 720, June 2020, article number 137528
Chan, Chi Kong; Tung, Ka Ki; Pavlović, Nikola M; Chan, Wan

Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability

Chemical Research in Toxicology, v. 33, (7), July 2020, p. 1815-1821
Ham, Yat Hing; Chan, Kwan Kit; Chan, Wan

Article 11

Aristolochic acids: Newly identified exposure pathways of this class of environmental and food-borne contaminants and its potential link to chronic kidney diseases

Toxics, v. 7, (1), March 2019, article number 14
Chan, Chi Kong; Liu, Yushuo; Nikola, M.Pavlović; Chan, Wan

Development of a Novel Liquid Chromatography-Tandem Mass Spectrometric Method for Aristolochic Acids Detection: Application in Food and Agricultural Soil Analyses

Food Chemistry, v. 289, August 2019, p. 673-679
Chan, Chi Kong; Pavlović, Nikola M.; Chan, Wan

Evaluating the Performance of Sample Preparation Methods for Ultra-performance Liquid Chromatography/mass Spectrometry Based Serum Metabonomics

Rapid Communications in Mass Spectrometry, v. 33, (6), March 2019, p. 561-568
Chan, Wan; Zhao, Yao; Zhang, Jiayin

Gas-Phase Fragmentation Reactions of Protonated Cystine Using High-Resolution Tandem Mass Spectrometry

Molecules, v. 24, (4), February 2019, article number 747
Zhang, Pengwei; Chan, Wan; Ang, Irene L.; Wei, Rui; Lam, Melody M. T.; Lei, Kate M. K.; Poon, Terence C. W.

Investigation of the Chemical Structure and Formation Mechanism of Polydopamine From Self-assembly of Dopamine by Liquid Chromatography/mass Spectrometry Coupled With Isotope-labelling Techniques

Rapid Communications in Mass Spectrometry, v. 33, (5), March 2019, p. 429-436
Chan, Wan

Liquid chromatography–tandem mass spectrometry analysis of aristolochic acids in soil samples collected from Serbia: Link to Balkan endemic nephropathy

Rapid Communications in Mass Spectrometry, August 2019
Chan, Chi Kong; Chan, Kwan Kit; Pavlović, N.M.; Chan, Wan

Quantification of a Novel DNA–Protein Cross-Link Product Formed by Reacting Apurinic/Apyrimidinic Sites in DNA with Cysteine Residues in Protein by Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method

Analytical Chemistry, v. 91, (8), 16 April 2019, p. 4987-4994
Chan, Wan; Ham, Yat Hing; Jin, Long; Chan, Ho Wai; Wong, Yee Lam; Chan, Chi Kong; Chung, Pui Yin

Quantitation of DNA Adducts in Target and Nontarget Organs of Aristolochic Acid I-Exposed Rats: Correlating DNA Adduct Levels with Organotropic Activities

Chemical Research in Toxicology, v. 32, (3), March 2019, p. 397-399
Liu, Yushuo; Chan, Chi Kong; Jin, Long; Wong, Sum Kok; Chan, Wan

Quantitation of N6-Formyl-lysine Adduct Following Aristolochic Acid Exposure in Cells and Rat Tissues by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope-Dilution Method

Chemical Research in Toxicology, v. 32, (10), October 2019, p. 2086-2094
Zhao, Yao; Chan, Chi Kong; Chan, Kwan Kit; Chan, Wan

Revisiting Fragmentation Reactions of Protonated alpha-Amino Acids by High-Resolution Electrospray lonization Tandem Mass Spectrometry with Collision-Induced Dissociation

Scientific Reports, v. 9, April 2019, article number 6453
Zhang, Pengwei; Chan, Wan; Ang, Irene L.; Wei, Rui; Lam, Melody M. T.; Lei, Kate M. K.; Poon, Terence C. W.

Transcriptomic Responses of the Marine Cyanobacterium Prochlorococcus to Viral Lysis Products

Environmental Microbiology, v. 21, (6), June 2019, p. 2015-2028
Fang, Xiaoting; Liu, Yaxin; Zhao, Yao; Chen, Yue; Liu, Riyue; Qin, Qi-Long; Li, Gang; Zhang, Yu-Zhong; Chan, Wan; Hess, Wolfgang R.; Zeng, Qinglu

Article 5

Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake

Journal of Agricultural and Food Chemistry, v. 66, (43), October 2018, p. 11468-11476
Li, Weiwei; Chan, Chi Kong; Liu, Yushuo; Yao, Jing; Mitic, Branka; Kostic, Emina N.; Milosavljevic, Biljana; Davinic, Ivana; Orem, William H.; Tatu, Calin A.; Dedon, Peter C.; Pavlovic, Nikola M.; Chan, Wan

Cooking Methods Employing Natural Anti-oxidant Food Additives Effectively Reduced Concentration of Nephrotoxic and Carcinogenic Aristolochic Acids in Contaminated Food Grains

Food Chemistry, v 264, October 2018, p. 270-276
Li, Weiwei; Chan, Chi Kong; Wong, Yee Lam; Chan, Kwan Kit Jason; Chan, Ho Wai; Chan, Wan

Etiology of Balkan Endemic Nephropathy: An Update on Aristolochic Acids Exposure Mechanisms

Chemical Research in Toxicology, v. 31, (11), November 2018, p. 1109-1110
Chan, Chi Kong; Liu, Yushuo; Pavlovic, Nikola M.; Chan, Wan

Quantification of DNA and Protein Adducts of 1‑Nitropyrene: Significantly Higher Levels of Protein than DNA Adducts in the Internal Organs of 1‑Nitropyrene Exposed Rats

Chemical Research in Toxicology, v. 31, (8), Aug 2018, p. 680-687
Chan, Wan; Wong, Sum Kok; Li, Weiwei

Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in Vitamin K Biosynthesis

ChemBioChem, v. 19, (14), July 2018, p. 1514-1522
Qin, Mingming; Song, Haigang; Dai, Xin; Chan, Chi Kong; Chan, Wan; Guo, Zhihong

Article 3

Determination of 2-alkylcyclobutanones in Ultraviolet Light-irradiated Fatty Acids, Triglycerides, Corn oil, and Pork Samples: Identifying a New Source of 2-alkylcyclobutanones

Food Chemistry, v. 217, February 2017, p. 352-359
Meng, Xiangpeng; Chan, Wan

Development of a QuEChERS-Based Method for Determination of Carcinogenic 2-Nitrofluorene and 1-Nitropyrene in Rice Grains and Vegetables: A Comparative Study with Benzo[a]pyrene

Journal of Agricultural and Food Chemistry, v. 65, (9), 8 Mar 2017, p. 1992-1999
Deng, Kailin; Chan, Simon Wan

Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil

Journal of Agricultural and Food Chemistry, v. 65, (21), May 2017, p. 4255-4261
Wang, Yinan; Chan, Kwan Kit Jason; Chan, Wan

Conference paper 1

A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis

Song, Haigang; Qin, Mingming; Chen, Dong; Dai, Xin; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong

Article 12

A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis

Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong

An Investigation on the Chemical Structure of Nitrogen and Sulfur Codoped Carbon Nanoparticles by Ultra-performance Liquid Chromatography-tandem Mass Spectrometry

Analytical and Bioanalytical Chemistry, v. 408, (19), July 2016, p. 5347-5357
Hu, Qin; Meng, Xiangpeng; Chan, Wan

Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography -Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples

Journal of Agricultural and Food Chemistry, v. 64, (13), April 2016, p. 2802-2808
Wang, Yinan; Chan, Wan

Determination of 2-alkylcyclobutanones by Combining Precolumn Derivatization with 1-naphthalenyl hydrazine and Ultra-performance Liquid Chromatography with Fluorescence Detection

Analytical and Bioanalytical Chemistry, v. 408, (14), May 2016, p. 3707-3714
Meng, Xiangpeng; Tong, Tong; Wang, Lianrong; Liu, Hanxia; Chan, Wan

Determination of DNA Adducts by Combining Acid-Catalyzed Hydrolysis and Chromatographic Analysis of the Carcinogens-Modified Nucleobases

Analytical and Bioanalytical Chemistry, v. 408, (3), January 2016, p. 953-961
Leung, Ming Kit; Deng, Kailin; Wong, Tin Yan; Chan, Wan

Elucidating the structure of carbon nanoparticles by ultra-performance liquid chromatography coupled with electrospray ionisation quadrupole time-of-flight tandem mass spectrometry

Analytica Chimica Acta, v. 911, March 2016, p. 100-107
Hu, Qin; Meng, Xiangpeng; Choi, Martin M. F.; Gong, Xiaojuan; Chan, Wan

Facile Formation of a DNA Adduct of Semicarbazide on Reaction with Apurinic/Apyrimidinic Sites in DNA

Chemical Research in Toxicology, v. 29, (5), May 2016, p. 834-840
Wang, Yinan; Chan, Ho Wai; Chan, Wan

Identification of Protein Thiazolidination as a Novel Molecular Signature for Oxidative Stress and Formaldehyde Exposure

Chemical Research in Toxicology, v. 29, (11), November 2016, p. 1865-1871
Liu, Jingjing; Chan, Kwan Kit Jason; Chan, Wan

Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy

Journal of Agricultural and Food Chemistry, v. 64, (29), July 2016, p. 5928-5934
Chan, Wan; Pavlović, Nikola M.; Li, Weiwei; Chan, Chi Kong; Liu, Jingjing; Deng, Kailin; Wang, Yinan; Milosavljević, Biljana; Kostić, Emina N.

Quantitation of the DNA Adduct of Semicarbazide in Organs of Semicarbazide-Treated Rats by Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry: A Comparative Study with the RNA Adduct

Chemical Research in Toxicology, v. 29, (9), September 2016, p. 1560-1564
Wang, Yinan; Wong, Tin Yan; Chan, Simon Wan

Quantitation of Thioprolines in Grape Wine by Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry

Journal of Agricultural and Food Chemistry, v. 64, (6), February 2016, p. 1361-1366
Liu, Jingjing; Meng, Xiangpeng; Chan, Wan

Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water

Journal of Agricultural and Food Chemistry, v. 64, (1), January 2016, p. 107-112
Li, Weiwei; Hu, Qin; Chan, Wan

Article 9

Combination of Precolumn Nitro-reduction and Ultraperformance Liquid Chromatography with Fluorescence Detection for the Sensitive Quantification of 1-Nitronaphthalene, 2-Nitrofluorene, and 1-Nitropyrene in Meat Products

Journal of Agricultural and Food Chemistry, v. 63, (12), April 2015, p. 3161-3167
Deng, Kailin; Wong, Tin Yan; Wang, Yinan; Leung, Elvis Ming Kit; Chan, Simon Wan

Comparison of DNA and RNA adduct formation: Significantly higher levels of RNA than DNA modifications in the internal organs of aristolochic acids-dosed rats

Chemical Research in Toxicology, v. 28, (2), February 2015, p. 248-255
Leung, Elvis Ming Kit; Chan, Simon Wan

Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry

Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan

Mass spectrometric and spectrofluorometric studies of the interaction of aristolochic acids with proteins

Scientific Reports, v. 5, October 2015, article number 15192
Li, Weiwei; Hu, Qin; Chan, Wan

Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin

Analytical Chemistry, v. 87, (15), August 2015, p. 7958-7963
Li, Yuanjiao; Liu, Jingjing; Wang, Yajie; Chan, Ho Wai; Wang, Lianrong; Chan, Wan

Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (35), September 2015, p. E4845-E4853
Jumpathong, Watthanachai; Chan, Wan; Taghizadeh, Koli; Babu, I. Ramesh; Dedon, Peter C.

Quantification of Aristolochic Acid-RNA Adducts in the Urine of Aristolochic Acid-Treated Rats by Liquid Chromatography-Tandem Mass Spectrometry

Chemical Research in Toxicology, v. 28, (4), April 2015, p. 567-569
Leung, Elvis M.K.; Chan, Wan

Quantification of Thiazolidine-4-carboxylic Acid in Toxicant-Exposed Cells by Isotope-Dilution Liquid Chromatography-Mass Spectrometry Reveals an Intrinsic Antagonistic Response to Oxidative Stress-Induced Toxicity

Chemical Research in Toxicology, v. 28, (3), March 2015, p. 394-400
Liu, Jingjing; Chan, Wan

Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB

Scientific Reports, v. 5, July 2015, article number 12368
He, Wei; Huang, Teng; Tang, You; Liu, Yanhua; Wu, Xiaolin; Chen, Si; Chan, Wan; Wang, Yajie; Liu, Xiaoyun; Chen, Shi; Wang, Lianrong

Article 4

A novel reversed-phase HPLC method for the determination of urinary creatinine by pre-column derivatization with ethyl chloroformate: comparative studies with the standard Jaffé , and isotope-dilution mass spectrometric assays

Analytical and Bioanalytical Chemistry, v. 406, (6), February 2014, p. 1807-1812
Leung, Elvis Ming Kit; Chan, Wan

Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection

Journal of Agricultural and Food Chemistry, v. 62, (25), June 2014, p. 5859-5864
Wang, Yinan; Chan, Wan

Noninvasive measurement of aristolochic acid-DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectrometry: Evidence for DNA repair by nucleotide-excision repair mechanisms

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, v. 766, August 2014, p. 1-6
Leung, Elvis Ming Kit; Chan, Simon Wan

Rapid identification of gamma-irradiated food by direct solvent extraction and liquid chromatography-tandem mass spectrometric analysis of 2-dodecylcyclobutanone: Application in surveillance of irradiated food

Food Chemistry, v. 161, October 2014, p. 312-316
Chan, Simon Wan; Ye, Yuran; Leung, Elvis Ming Kit

Article 6

Analysis of 2-Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2-Alkylcyclobutanones for Irradiated Food Identification

Journal of Agricultural and Food Chemistry, v. 61, (41), October 2013, p. 9950-9954
Leung, Elvis Ming Kit; Tang, Phyllis Nya Yang; Ye, Yuran; Chan, Wan

Capillary electrophoretic study of amine/carboxylic acid-functionalized carbon nanodots

Journal of Chromatography A, v. 1304, August 2013, p. 234-240
Hu, Qin; Paau, Man Chin; Zhang, Yan; Chan, Wan; Gong, Xiaojuan; Zhang, Lei; Choi, Martin M.F.

Combination of pentafluorophenylhydrazine derivatization and isotope dilution LC-MS/MS techniques for the quantification of apurinic/apyrimidinic sites in cellular DNA

Analytical and Bioanalytical Chemistry, v. 405, (12), 2013, p. 4059-4066
Li, Jie; Leung, Elvis Ming Kit; Choi, Martin Ming Fat; Chan, Wan

Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, v. 74, February 2013, p. 156-161
Li, Jie; Chan, Wan

Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometric Analysis of 2-Alkylcyclobutanones in Irradiated Chicken by Precolumn Derivatization with Hydroxylamine

Journal of Agricultural and Food Chemistry, v. 61, (24), June 2013, p. 5758-5763
Ye, Yuran; Liu, Hanxia; Horvatovich, Peter; Chan, Wan

Probing Histidine-Stabilized Gold Nanoclusters Product by High-Performance Liquid Chromatography and Mass Spectrometry

Journal of Physical Chemistry C, v. 117, (36), September 2013, p. 18697-18708
Zhang, Yan; Hu, Qin; Paau, Man Chin; Xie, Shunping; Gao, Pengfei; Chan, Wan; Choi, Martin Ming Fat

Article 2

High-performance liquid chromatographic analysis of as-synthesised N,N '-dimethylformamide-stabilised gold nanoclusters product

Nanoscale, v. 4, (17), 2012, p. 5325-5332
Xie, Shunping; Paau, Man Chin; Zhang, Yan; Shuang, Shaomin; Chan, Wan; Choi, Martin M.F.

In situ analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra

Journal of the American Chemical Society, v. 134, (43), 2012, p. 18053-18064
Lim, K.S.; Cui, L.; Taghizadeh, K.; Wishnok, J.S.; Chan, Wan; Demott, M.S.; Babu, I.R.; Tannenbaum, S.R.; Dedon, P.C.

Article 2

DNA phosphorothioation is widespread and quantized in bacterial genomes

Proceedings of the National Academy of Sciences of the United States of America, v. 108, (7), 2011, p. 2963-2968
Wang, Lianrong; Chen, Shi; Vergin, Kevin, L.; Giovannoni, Stephen J.; Chan, Simon Wan; Demott, Michael S.; Taghizadeh, Koli; Cordero, Otto X.; Cutler, Michael; Timberlake, Sonia; Alm, Eric J.; Polz, Martin F.; Pinhassi, Jarone; Deng, Zixin; Dedon, Peter C.

Metabolomics Analysis of the Responses to Partial Hepatectomy in Hepatocellular Carcinoma Patients

American Journal of Analytical Chemistry, v. 2, 2011, p. 142-151
Chan, Wan; Lin, Shuhai; Sun, Stella; Liu, Hongde; Cai, Zongwei; Luk, John M.

Article 3

Liquid chromatography/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: the plasma metabolome

Rapid Communications in Mass Spectrometry, v. 24, (9), 2010, p. 1312-1318
Lin, Shuhai; Chan, Wan; Li, Jinhua; Cai, Zongwei

Quantification of the 2-Deoxyribonolactone and Nucleoside 5′-Aldehyde Products of 2-Deoxyribose Oxidation in DNA and Cells by Isotope-Dilution Gas Chromatography Mass Spectrometry: Differential Effects of γ-Radiation and Fe²⁺−EDTA

Journal of the American Chemical Society, v. 132, (17), 2010, p. 6145-6153
Chan, Wan; Chen, Bingzi; Wang, Lianrong; Taghizadeh, Koli; Demott, Michael S.; Dedon, Peter C.

The biological and metabolic fates of endogenous DNA damage products

Journal of Nucleic Acids, v. 2010, 2010, article number 929047
Chan, Simon Wan; Dedon, Peter C.

Article 5

A Method to Enhance a 1 Ions and Application for Peptide Sequencing and Protein Identification

Journal of the American Society for Mass Spectrometry, v. 20, (6), 2009, p. 1214-1223
Liu, N.; Chan, Wan; Lee, K.C.; Cai, Z.

A new approach for the sensitive determination of DNA adduct of aristolochic acid II by using high-performance liquid chromatography with fluorescence detection

Journal of chromatography. B, v. 877, (10), 2009, p. 848-852
Chan, Wan; Poon, W.T.; Chan, Y.W.; Wan, K.Y.; Cai, Z.

Determination of aristolochic acid I in rat urine and plasma by high-performance liquid chromatography with fluorescence detection

Journal of chromatography. B, v. 877, (10), 2009, p. 995-999
Yue, H.; Chan, Wan; Guo, L.; Cai, Z.

On-line capillary electrophoresis-electrospray ionization mass spectrometry analysis of urinary porphyrins

Electrophoresis, v. 30, 2009, p. 1790-1797
Li, JH; Chan, Wan; Cai, ZW

Recent progress in quantitative analysis of DNA adducts of nephrotoxin aristolochic acid

Science in China. Series B, Chemistry, v. 52, (10), 2009, p. 1576-1582
Yue, H.; Chan, Wan; Yu, K.; Guo, L.; Liu, N.; Liu, H.; Cai, Z.

Article 8

Aristolochic acid induced changes in the metabolic profile of rat urine

Journal of pharmaceutical and biomedical analysis, v. 46, (4), 2008, p. 757-762
Chan, Wan; Cai, Z.

Characterization of the DNA adducts induced by aristolochic acids in oligonucleotides by electrospray ionization tandem mass spectrometry

Rapid communications in mass spectrometry, v. 22, (23), 2008, p. 3735-3742
Chan, Wan; Yue, H.; Wong, R.N.S.; Cai, Z.

High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen

Talanta, v. 75, (4), 2008, p. 1002-1007
Cui, L.; Chan, Wan; Wu, J.L.; Jiang, Z.H.; Chan, K.; Cai, Z.

Identification of four urea adducts of Andrographolide in human

Drug Metab. Lett., v. 2, 2008, p. 261-268
Cui, L.; Chan, Wan; Qiu, F.; Cai, ZW; Yao, Z.

Liquid chromatography/mass spectrometry for metabonomics investigation of the biochemical effects induced by aristolochic acid in rats: The use of information-dependent acquisition for biomarker identification

Rapid communications in mass spectrometry, v. 22, (6), 2008, p. 873-880
Chan, Wan; Lee, K.C.; Liu, N.; Wong, R.N.S.; Liu, H.; Cai, Z.

Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells

Proteomics, v. 8, 2008, p. 1851-1858
Liu, N.; Song, WJ; Wang, P.; Lee, KC; Chan, Wan; Chen, HL; Cai, ZW

Quantification of Aristolochic Acid-Derived DNA Adducts in Rat Kidney and Liver by Using Liquid Chromatography-Electrospray Ionization Mass Spectrometry

Mutat. Res, v. 646, 2008, p. 17-24
Chan, Wan; Yue, H.; Poon, WY; Chan,Y-W; Schmitz, Oliver J.; Kwong, Daniel WJ; Wong, Ricky NS; Cai, ZW

Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry in negative ion mode

Rapid communications in mass spectrometry, v. 22, (18), 2008, p. 2825-2834
Lee, K.C.; Chan, Wan; Liang, Z.; Liu, N.; Zhao, Z.; Lee, A.W.M.; Cai, Z.

Article 3

A sensitivity enhanced high-performance liquid chromatography fluorescence method for the detection of nephrotoxic and carcinogenic aristolochic acid in herbal medicines

Journal of chromatography. A, v. 1164, (1-2), 2007, p. 113-119
Chan, Wan; Lee, K.C.; Liu, N.; Cai, ZW

Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats

Drug Metab. Dispos, v. 35, 2007, p. 866-874
Chan, Wan; Luo, HB; Zheng, YF; Cheng, YK; Cai, ZW

Liquid Chromatography-Tandem Mass Spectrometry Analysis of the DNA Adducts of Aristolochic Acids

Journal of the American Society for Mass Spectrometry, v. 18, (4), 2007, p. 642-650
Chan, Wan; Zheng, Y.; Cai, Z.

Conference paper 1

Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry

Analytical and bioanalytical chemistry, v. 387, (6), 2007, p. 2219-2225
Ma, W.T.; Chan, Wan; Steinbach, K.; Cai, Z.

Article 3

Determination of glucosinolates in traditional Chinese herbs by high-performance liquid chromatography and electrospray ionization mass spectrometry

Analytical and bioanalytical chemistry, v. 386, (7-8), 2006, p. 2225-2232
Lee, K.C.; Cheuk, M.W.; Chan, Wan; Lee, A.W.M.; Zhao, Z.Z.; Jiang, Z.H.; Cai, Z.

Differentiation of herbs linked to "Chinese herb nephropathy" from the liquid chromatographic determination of aristolochic acids

Analytica Chimica Acta, v. 576, (1), 2006, p. 112-116
Chan, Wan; Hui, K.M.; Poon, W.T.; Lee, K.C.; Cai, Z.

Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, v. 20, (11), 2006, p. 1755-1760
Chan, Wan; Cui, L.; Xu, G.; Cai, Z.

Article 1

Identification of components in traditional Chinese medicinal products using LC-MS

Encyclopedia of Mass Spectrometry (V8), Pergamon Pr, 2005, article number: Else_EMASV008_93
Chan, Wan; Cai, ZW

2018 5

Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake

Journal of Agricultural and Food Chemistry, v. 66, (43), October 2018, p. 11468-11476
Li, Weiwei; Chan, Chi Kong; Liu, Yushuo; Yao, Jing; Mitic, Branka; Kostic, Emina N.; Milosavljevic, Biljana; Davinic, Ivana; Orem, William H.; Tatu, Calin A.; Dedon, Peter C.; Pavlovic, Nikola M.; Chan, Wan
Article

Cooking Methods Employing Natural Anti-oxidant Food Additives Effectively Reduced Concentration of Nephrotoxic and Carcinogenic Aristolochic Acids in Contaminated Food Grains

Food Chemistry, v 264, October 2018, p. 270-276
Li, Weiwei; Chan, Chi Kong; Wong, Yee Lam; Chan, Kwan Kit Jason; Chan, Ho Wai; Chan, Wan
Article

Etiology of Balkan Endemic Nephropathy: An Update on Aristolochic Acids Exposure Mechanisms

Chemical Research in Toxicology, v. 31, (11), November 2018, p. 1109-1110
Chan, Chi Kong; Liu, Yushuo; Pavlovic, Nikola M.; Chan, Wan
Article

Quantification of DNA and Protein Adducts of 1‑Nitropyrene: Significantly Higher Levels of Protein than DNA Adducts in the Internal Organs of 1‑Nitropyrene Exposed Rats

Chemical Research in Toxicology, v. 31, (8), Aug 2018, p. 680-687
Chan, Wan; Wong, Sum Kok; Li, Weiwei
Article

Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in Vitamin K Biosynthesis

ChemBioChem, v. 19, (14), July 2018, p. 1514-1522
Qin, Mingming; Song, Haigang; Dai, Xin; Chan, Chi Kong; Chan, Wan; Guo, Zhihong
Article

2017 4

Determination of 2-alkylcyclobutanones in Ultraviolet Light-irradiated Fatty Acids, Triglycerides, Corn oil, and Pork Samples: Identifying a New Source of 2-alkylcyclobutanones

Food Chemistry, v. 217, February 2017, p. 352-359
Meng, Xiangpeng; Chan, Wan
Article

Development of a QuEChERS-Based Method for Determination of Carcinogenic 2-Nitrofluorene and 1-Nitropyrene in Rice Grains and Vegetables: A Comparative Study with Benzo[a]pyrene

Journal of Agricultural and Food Chemistry, v. 65, (9), 8 Mar 2017, p. 1992-1999
Deng, Kailin; Chan, Simon Wan
Article

Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil

Journal of Agricultural and Food Chemistry, v. 65, (21), May 2017, p. 4255-4261
Wang, Yinan; Chan, Kwan Kit Jason; Chan, Wan
Article

A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis

Song, Haigang; Qin, Mingming; Chen, Dong; Dai, Xin; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong
Conference paper

2016 12

A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis

Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong
Article

An Investigation on the Chemical Structure of Nitrogen and Sulfur Codoped Carbon Nanoparticles by Ultra-performance Liquid Chromatography-tandem Mass Spectrometry

Analytical and Bioanalytical Chemistry, v. 408, (19), July 2016, p. 5347-5357
Hu, Qin; Meng, Xiangpeng; Chan, Wan
Article

Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography -Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples

Journal of Agricultural and Food Chemistry, v. 64, (13), April 2016, p. 2802-2808
Wang, Yinan; Chan, Wan
Article

Determination of 2-alkylcyclobutanones by Combining Precolumn Derivatization with 1-naphthalenyl hydrazine and Ultra-performance Liquid Chromatography with Fluorescence Detection

Analytical and Bioanalytical Chemistry, v. 408, (14), May 2016, p. 3707-3714
Meng, Xiangpeng; Tong, Tong; Wang, Lianrong; Liu, Hanxia; Chan, Wan
Article

Determination of DNA Adducts by Combining Acid-Catalyzed Hydrolysis and Chromatographic Analysis of the Carcinogens-Modified Nucleobases

Analytical and Bioanalytical Chemistry, v. 408, (3), January 2016, p. 953-961
Leung, Ming Kit; Deng, Kailin; Wong, Tin Yan; Chan, Wan
Article

Elucidating the structure of carbon nanoparticles by ultra-performance liquid chromatography coupled with electrospray ionisation quadrupole time-of-flight tandem mass spectrometry

Analytica Chimica Acta, v. 911, March 2016, p. 100-107
Hu, Qin; Meng, Xiangpeng; Choi, Martin M. F.; Gong, Xiaojuan; Chan, Wan
Article

Facile Formation of a DNA Adduct of Semicarbazide on Reaction with Apurinic/Apyrimidinic Sites in DNA

Chemical Research in Toxicology, v. 29, (5), May 2016, p. 834-840
Wang, Yinan; Chan, Ho Wai; Chan, Wan
Article

Identification of Protein Thiazolidination as a Novel Molecular Signature for Oxidative Stress and Formaldehyde Exposure

Chemical Research in Toxicology, v. 29, (11), November 2016, p. 1865-1871
Liu, Jingjing; Chan, Kwan Kit Jason; Chan, Wan
Article

Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy

Journal of Agricultural and Food Chemistry, v. 64, (29), July 2016, p. 5928-5934
Chan, Wan; Pavlović, Nikola M.; Li, Weiwei; Chan, Chi Kong; Liu, Jingjing; Deng, Kailin; Wang, Yinan; Milosavljević, Biljana; Kostić, Emina N.
Article

Quantitation of the DNA Adduct of Semicarbazide in Organs of Semicarbazide-Treated Rats by Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry: A Comparative Study with the RNA Adduct

Chemical Research in Toxicology, v. 29, (9), September 2016, p. 1560-1564
Wang, Yinan; Wong, Tin Yan; Chan, Simon Wan
Article

Quantitation of Thioprolines in Grape Wine by Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry

Journal of Agricultural and Food Chemistry, v. 64, (6), February 2016, p. 1361-1366
Liu, Jingjing; Meng, Xiangpeng; Chan, Wan
Article

Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water

Journal of Agricultural and Food Chemistry, v. 64, (1), January 2016, p. 107-112
Li, Weiwei; Hu, Qin; Chan, Wan
Article

2015 9

Combination of Precolumn Nitro-reduction and Ultraperformance Liquid Chromatography with Fluorescence Detection for the Sensitive Quantification of 1-Nitronaphthalene, 2-Nitrofluorene, and 1-Nitropyrene in Meat Products

Journal of Agricultural and Food Chemistry, v. 63, (12), April 2015, p. 3161-3167
Deng, Kailin; Wong, Tin Yan; Wang, Yinan; Leung, Elvis Ming Kit; Chan, Simon Wan
Article

Comparison of DNA and RNA adduct formation: Significantly higher levels of RNA than DNA modifications in the internal organs of aristolochic acids-dosed rats

Chemical Research in Toxicology, v. 28, (2), February 2015, p. 248-255
Leung, Elvis Ming Kit; Chan, Simon Wan
Article

Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry

Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan
Article

Mass spectrometric and spectrofluorometric studies of the interaction of aristolochic acids with proteins

Scientific Reports, v. 5, October 2015, article number 15192
Li, Weiwei; Hu, Qin; Chan, Wan
Article

Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin

Analytical Chemistry, v. 87, (15), August 2015, p. 7958-7963
Li, Yuanjiao; Liu, Jingjing; Wang, Yajie; Chan, Ho Wai; Wang, Lianrong; Chan, Wan
Article

Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (35), September 2015, p. E4845-E4853
Jumpathong, Watthanachai; Chan, Wan; Taghizadeh, Koli; Babu, I. Ramesh; Dedon, Peter C.
Article

Quantification of Aristolochic Acid-RNA Adducts in the Urine of Aristolochic Acid-Treated Rats by Liquid Chromatography-Tandem Mass Spectrometry

Chemical Research in Toxicology, v. 28, (4), April 2015, p. 567-569
Leung, Elvis M.K.; Chan, Wan
Article

Quantification of Thiazolidine-4-carboxylic Acid in Toxicant-Exposed Cells by Isotope-Dilution Liquid Chromatography-Mass Spectrometry Reveals an Intrinsic Antagonistic Response to Oxidative Stress-Induced Toxicity

Chemical Research in Toxicology, v. 28, (3), March 2015, p. 394-400
Liu, Jingjing; Chan, Wan
Article

Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB

Scientific Reports, v. 5, July 2015, article number 12368
He, Wei; Huang, Teng; Tang, You; Liu, Yanhua; Wu, Xiaolin; Chen, Si; Chan, Wan; Wang, Yajie; Liu, Xiaoyun; Chen, Shi; Wang, Lianrong
Article

2014 4

A novel reversed-phase HPLC method for the determination of urinary creatinine by pre-column derivatization with ethyl chloroformate: comparative studies with the standard Jaffé , and isotope-dilution mass spectrometric assays

Analytical and Bioanalytical Chemistry, v. 406, (6), February 2014, p. 1807-1812
Leung, Elvis Ming Kit; Chan, Wan
Article

Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection

Journal of Agricultural and Food Chemistry, v. 62, (25), June 2014, p. 5859-5864
Wang, Yinan; Chan, Wan
Article

Noninvasive measurement of aristolochic acid-DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectrometry: Evidence for DNA repair by nucleotide-excision repair mechanisms

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, v. 766, August 2014, p. 1-6
Leung, Elvis Ming Kit; Chan, Simon Wan
Article

Rapid identification of gamma-irradiated food by direct solvent extraction and liquid chromatography-tandem mass spectrometric analysis of 2-dodecylcyclobutanone: Application in surveillance of irradiated food

Food Chemistry, v. 161, October 2014, p. 312-316
Chan, Simon Wan; Ye, Yuran; Leung, Elvis Ming Kit
Article

2013 6

Analysis of 2-Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2-Alkylcyclobutanones for Irradiated Food Identification

Journal of Agricultural and Food Chemistry, v. 61, (41), October 2013, p. 9950-9954
Leung, Elvis Ming Kit; Tang, Phyllis Nya Yang; Ye, Yuran; Chan, Wan
Article

Capillary electrophoretic study of amine/carboxylic acid-functionalized carbon nanodots

Journal of Chromatography A, v. 1304, August 2013, p. 234-240
Hu, Qin; Paau, Man Chin; Zhang, Yan; Chan, Wan; Gong, Xiaojuan; Zhang, Lei; Choi, Martin M.F.
Article

Combination of pentafluorophenylhydrazine derivatization and isotope dilution LC-MS/MS techniques for the quantification of apurinic/apyrimidinic sites in cellular DNA

Analytical and Bioanalytical Chemistry, v. 405, (12), 2013, p. 4059-4066
Li, Jie; Leung, Elvis Ming Kit; Choi, Martin Ming Fat; Chan, Wan
Article

Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, v. 74, February 2013, p. 156-161
Li, Jie; Chan, Wan
Article

Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometric Analysis of 2-Alkylcyclobutanones in Irradiated Chicken by Precolumn Derivatization with Hydroxylamine

Journal of Agricultural and Food Chemistry, v. 61, (24), June 2013, p. 5758-5763
Ye, Yuran; Liu, Hanxia; Horvatovich, Peter; Chan, Wan
Article

Probing Histidine-Stabilized Gold Nanoclusters Product by High-Performance Liquid Chromatography and Mass Spectrometry

Journal of Physical Chemistry C, v. 117, (36), September 2013, p. 18697-18708
Zhang, Yan; Hu, Qin; Paau, Man Chin; Xie, Shunping; Gao, Pengfei; Chan, Wan; Choi, Martin Ming Fat
Article

2012 2

High-performance liquid chromatographic analysis of as-synthesised N,N '-dimethylformamide-stabilised gold nanoclusters product

Nanoscale, v. 4, (17), 2012, p. 5325-5332
Xie, Shunping; Paau, Man Chin; Zhang, Yan; Shuang, Shaomin; Chan, Wan; Choi, Martin M.F.
Article

In situ analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra

Journal of the American Chemical Society, v. 134, (43), 2012, p. 18053-18064
Lim, K.S.; Cui, L.; Taghizadeh, K.; Wishnok, J.S.; Chan, Wan; Demott, M.S.; Babu, I.R.; Tannenbaum, S.R.; Dedon, P.C.
Article

2011 2

DNA phosphorothioation is widespread and quantized in bacterial genomes

Proceedings of the National Academy of Sciences of the United States of America, v. 108, (7), 2011, p. 2963-2968
Wang, Lianrong; Chen, Shi; Vergin, Kevin, L.; Giovannoni, Stephen J.; Chan, Simon Wan; Demott, Michael S.; Taghizadeh, Koli; Cordero, Otto X.; Cutler, Michael; Timberlake, Sonia; Alm, Eric J.; Polz, Martin F.; Pinhassi, Jarone; Deng, Zixin; Dedon, Peter C.
Article

Metabolomics Analysis of the Responses to Partial Hepatectomy in Hepatocellular Carcinoma Patients

American Journal of Analytical Chemistry, v. 2, 2011, p. 142-151
Chan, Wan; Lin, Shuhai; Sun, Stella; Liu, Hongde; Cai, Zongwei; Luk, John M.
Article

2010 3

Liquid chromatography/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: the plasma metabolome

Rapid Communications in Mass Spectrometry, v. 24, (9), 2010, p. 1312-1318
Lin, Shuhai; Chan, Wan; Li, Jinhua; Cai, Zongwei
Article

Quantification of the 2-Deoxyribonolactone and Nucleoside 5′-Aldehyde Products of 2-Deoxyribose Oxidation in DNA and Cells by Isotope-Dilution Gas Chromatography Mass Spectrometry: Differential Effects of γ-Radiation and Fe²⁺−EDTA

Journal of the American Chemical Society, v. 132, (17), 2010, p. 6145-6153
Chan, Wan; Chen, Bingzi; Wang, Lianrong; Taghizadeh, Koli; Demott, Michael S.; Dedon, Peter C.
Article

The biological and metabolic fates of endogenous DNA damage products

Journal of Nucleic Acids, v. 2010, 2010, article number 929047
Chan, Simon Wan; Dedon, Peter C.
Article

2009 5

A Method to Enhance a 1 Ions and Application for Peptide Sequencing and Protein Identification

Journal of the American Society for Mass Spectrometry, v. 20, (6), 2009, p. 1214-1223
Liu, N.; Chan, Wan; Lee, K.C.; Cai, Z.
Article

A new approach for the sensitive determination of DNA adduct of aristolochic acid II by using high-performance liquid chromatography with fluorescence detection

Journal of chromatography. B, v. 877, (10), 2009, p. 848-852
Chan, Wan; Poon, W.T.; Chan, Y.W.; Wan, K.Y.; Cai, Z.
Article

Determination of aristolochic acid I in rat urine and plasma by high-performance liquid chromatography with fluorescence detection

Journal of chromatography. B, v. 877, (10), 2009, p. 995-999
Yue, H.; Chan, Wan; Guo, L.; Cai, Z.
Article

On-line capillary electrophoresis-electrospray ionization mass spectrometry analysis of urinary porphyrins

Electrophoresis, v. 30, 2009, p. 1790-1797
Li, JH; Chan, Wan; Cai, ZW
Article

Recent progress in quantitative analysis of DNA adducts of nephrotoxin aristolochic acid

Science in China. Series B, Chemistry, v. 52, (10), 2009, p. 1576-1582
Yue, H.; Chan, Wan; Yu, K.; Guo, L.; Liu, N.; Liu, H.; Cai, Z.
Article

2008 8

Aristolochic acid induced changes in the metabolic profile of rat urine

Journal of pharmaceutical and biomedical analysis, v. 46, (4), 2008, p. 757-762
Chan, Wan; Cai, Z.
Article

Characterization of the DNA adducts induced by aristolochic acids in oligonucleotides by electrospray ionization tandem mass spectrometry

Rapid communications in mass spectrometry, v. 22, (23), 2008, p. 3735-3742
Chan, Wan; Yue, H.; Wong, R.N.S.; Cai, Z.
Article

High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen

Talanta, v. 75, (4), 2008, p. 1002-1007
Cui, L.; Chan, Wan; Wu, J.L.; Jiang, Z.H.; Chan, K.; Cai, Z.
Article

Identification of four urea adducts of Andrographolide in human

Drug Metab. Lett., v. 2, 2008, p. 261-268
Cui, L.; Chan, Wan; Qiu, F.; Cai, ZW; Yao, Z.
Article

Liquid chromatography/mass spectrometry for metabonomics investigation of the biochemical effects induced by aristolochic acid in rats: The use of information-dependent acquisition for biomarker identification

Rapid communications in mass spectrometry, v. 22, (6), 2008, p. 873-880
Chan, Wan; Lee, K.C.; Liu, N.; Wong, R.N.S.; Liu, H.; Cai, Z.
Article

Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells

Proteomics, v. 8, 2008, p. 1851-1858
Liu, N.; Song, WJ; Wang, P.; Lee, KC; Chan, Wan; Chen, HL; Cai, ZW
Article

Quantification of Aristolochic Acid-Derived DNA Adducts in Rat Kidney and Liver by Using Liquid Chromatography-Electrospray Ionization Mass Spectrometry

Mutat. Res, v. 646, 2008, p. 17-24
Chan, Wan; Yue, H.; Poon, WY; Chan,Y-W; Schmitz, Oliver J.; Kwong, Daniel WJ; Wong, Ricky NS; Cai, ZW
Article

Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry in negative ion mode

Rapid communications in mass spectrometry, v. 22, (18), 2008, p. 2825-2834
Lee, K.C.; Chan, Wan; Liang, Z.; Liu, N.; Zhao, Z.; Lee, A.W.M.; Cai, Z.
Article

2007 4

A sensitivity enhanced high-performance liquid chromatography fluorescence method for the detection of nephrotoxic and carcinogenic aristolochic acid in herbal medicines

Journal of chromatography. A, v. 1164, (1-2), 2007, p. 113-119
Chan, Wan; Lee, K.C.; Liu, N.; Cai, ZW
Article

Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats

Drug Metab. Dispos, v. 35, 2007, p. 866-874
Chan, Wan; Luo, HB; Zheng, YF; Cheng, YK; Cai, ZW
Article

Liquid Chromatography-Tandem Mass Spectrometry Analysis of the DNA Adducts of Aristolochic Acids

Journal of the American Society for Mass Spectrometry, v. 18, (4), 2007, p. 642-650
Chan, Wan; Zheng, Y.; Cai, Z.
Article

Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry

Analytical and bioanalytical chemistry, v. 387, (6), 2007, p. 2219-2225
Ma, W.T.; Chan, Wan; Steinbach, K.; Cai, Z.
Conference paper

2006 3

Determination of glucosinolates in traditional Chinese herbs by high-performance liquid chromatography and electrospray ionization mass spectrometry

Analytical and bioanalytical chemistry, v. 386, (7-8), 2006, p. 2225-2232
Lee, K.C.; Cheuk, M.W.; Chan, Wan; Lee, A.W.M.; Zhao, Z.Z.; Jiang, Z.H.; Cai, Z.
Article

Differentiation of herbs linked to "Chinese herb nephropathy" from the liquid chromatographic determination of aristolochic acids

Analytica Chimica Acta, v. 576, (1), 2006, p. 112-116
Chan, Wan; Hui, K.M.; Poon, W.T.; Lee, K.C.; Cai, Z.
Article

Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, v. 20, (11), 2006, p. 1755-1760
Chan, Wan; Cui, L.; Xu, G.; Cai, Z.
Article

2005 1

Identification of components in traditional Chinese medicinal products using LC-MS

Encyclopedia of Mass Spectrometry (V8), Pergamon Pr, 2005, article number: Else_EMASV008_93
Chan, Wan; Cai, ZW
Article

Teaching Assignment

2024-25 Fall 2 2023-24 Summer 0 2023-24 Spring 2 2023-24 Winter 0 2023-24 Fall 2 2022-23 Summer 0

CHEM2310	Fundamentals of Analytical Chemistry
CHMS5040	Separation Methods

CHEM4330	Separation Science
CHMS5112	Food and Drug Analysis

CHEM2310	Fundamentals of Analytical Chemistry
CHMS5040	Separation Methods

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

BAYER, Steevanson
Chemistry
XIAO, Kaiting
Chemistry
LUK, Wing Laam
Chemistry
NG, Ka Ki
Chemistry
TSE, Hei Tak
Chemistry
WANG, Shuangshuang
Chemistry
KWOK, Hong Ching
Chemistry

Master of Philosophy

CHENG, King Hei
Chemistry

Graduated RPGs

Doctor of Philosophy

CHIN, Man Lung
Chemistry( Completed in 2024 )
GUO, Wanlin
Chemistry( Completed in 2024 )
PAN, Guanrui
Chemistry( Completed in 2024 )
AU, Chun Kit
Chemistry( Completed in 2023 )
CHAN, Chi Kong
Chemistry( Completed in 2023 )
HAM, Yat Hing
Chemistry( Completed in 2023 )
JIN, Long
Chemistry( Completed in 2023 )
TUNG, Ka Ki
Chemistry( Completed in 2023 )
ZHANG, Jiayin
Chemistry( Completed in 2023 )
ZHAO, Yao
Chemistry( Completed in 2022 )

Master of Philosophy

CHOI, King San
Chemistry( Completed in 2024 )
ZHANG, Haoyu
Chemistry( Completed in 2024 )
NG, Ka Ki
Chemistry( Completed in 2023 )
TSE, Hei Tak
Chemistry( Completed in 2023 )
SUN, Zhihan
Chemistry( Completed in 2022 )

Projects

From January 2022 to December 2024

All Projects 8 Leading Projects 5 Participating Projects 3

Hidden Roles of the Gut Microbiome in Aristolochic Acid Nephrotoxicity and Risk Mitigation Strategies

腸道微生物在馬兜鈴酸腎炎中的角色和風險緩解策略研究 Leading

RGC - General Research Fund
Project Team (HKUST)
CHAN Simon Wan (Lead)
2024 -
Chemical Approaches to Investigate the Potential Health Effects of 2-Chlorobenzalmalononitrile and to Develop a Biomarker of Exposure

以化學方法研究2-氯苯亞甲基丙二腈的潛在健康影響並開發其暴露的生物標誌物 Leading

RGC - General Research Fund
Project Team (HKUST)
CHAN Simon Wan (Lead)
2022 -
Synergism of Kai-Xin-San, a Chinese Herbal Formula, with Fluoxetine in Relieving Symptoms of Depression and Side Effect: A Mechanistic Analysis Based on the Brain-Gut Axis

基於“腦-腸軸”調控研究中藥開心散與氟西汀聯合用藥抗抑鬱增效減副的作用機制 Participating

Dynamic Star Limited, Innovation and Technology Fund
Project Team (HKUST)
TSIM Karl Wah Keung (Lead)

CHAN Simon Wan
2022 - 2024
Survey of Environmental Pollution from Aristolochic Acids in Herbal Medicine Cultivation areas of Mainland China Leading

The TUYF Charitable Trust
Project Team (HKUST)
CHAN Simon Wan (Lead)

TSIM Karl Wah Keung
2021 -
Liquid chromatography-coupled mass spectrometry-based adductomics to discovery etiological agents and biomarkers of leukemia in human

液相色譜-串聯質譜法加合物組學用于發現人類白血病病原物及生物標志物 Leading

RGC - General Research Fund
Project Team (HKUST)
CHAN Simon Wan (Lead)
2021 - 2023
Research & Development of Traditional Chinese Medicine Classics formula——Data Platform Establishing

經典名方作用機理、物質基準和二次開發研究——數據平臺的建立 Participating

Nanhai People's Government of Foshan
Project Team (HKUST)
TSIM Karl Wah Keung (Lead)

CHAN Simon Wan

LAM Henry Hei Ning

WANG Yang
2020 - 2023
Developing Protein Adducts as Clinically Useful Biomarkers for Identifying Kidney Diseases Caused by Aristolochic Acids Exposure Using Mass Spectrometry-Based Analytical Methods

使用基于質譜分析方法開發蛋白加合物作為臨床上識別馬兜鈴酸導致的腎病的生物標志物 Leading

RGC - General Research Fund
Project Team (HKUST)
CHAN Simon Wan (Lead)
2020 - 2022
Recognition of the role of aristolochic acids poisoning in chronic kidney disease observed in China

闡明馬兜鈴酸中毒在中國慢性腎臟疾病中扮演的角色 Participating

The TUYF Charitable Trust
Project Team (HKUST)
CHAN Simon Wan

LAU Stanley Chun Kwan

TSIM Karl Wah Keung

YU Jianzhen
2018 - 2022

Research Interest

Publications

2024 4

2023 5

2022 5

2021 9

2020 10

2019 11

2018 5

2017 4

2016 12

2015 9

2014 4

2013 6

2012 2

2011 2

2010 3

2009 5

2008 8

2007 4

2006 3

2005 1

Article 4

Article 5

Article 5

Article 9

Article 10

Article 11

Article 5

Article 3

Conference paper 1

Article 12

Article 9

Article 4

Article 6

Article 2

Article 2

Article 3

Article 5

Article 8

Article 3

Conference paper 1

Article 3

Article 1

2018 5

2017 4

2016 12

2015 9

2014 4

2013 6

2012 2

2011 2

2010 3

2009 5

2008 8

2007 4

2006 3

2005 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

Current RPGs

Graduated RPGs

Projects

From January 2022 to December 2024

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