Faculty Profiles - DANG Shangyu | The Hong Kong University of Science and Technology

Shangyu DANG
黨尚宇

Doctor of Natural Science in Biology
Tsinghua University, 2014

Assistant Professor
Division of Life Science

ORCID

0000-0001-9141-1865

Scopus ID

26655423700

Research Interest

Structural biology
Deoxyribonucleic acid (DNA) replication
Protein-DNA complexes
Calcium signaling
Electron microscopy
Disease mechanisms
Proteins

Publications

2025 1

DNA bending mediated by ORC is essential for replication licensing in budding yeast

Proceedings of the National Academy of Sciences of the United States of America, v. 122, (14), April 2025, article number e2502277122
Lam, Wai Hei; Yu, Daqi; Zhang, Qiongdan; Lin, Yuhan; Li, Ningning; Wu, Yue; Zhang, Yingyi; Gao, Ning; Tye, Bik Kwoon; Zhai, Yuanliang; Dang, Shangyu
Article

2024 4

Metallo-supermolecular branched polymer protects particles from air-water interface in single-particle cryo-electron microscopy

Communications Biology, v. 7, (1), January 2024, article number 65
Xu, Yixin; Qin, Yuqi; Wang, Lang; Zhang, Yingyi; Wang, Yufeng; Dang, Shangyu
Article

Modular Structure and Polymerization Status of GABA_A Receptors Illustrated with EM Analysis and AlphaFold2 Prediction

International Journal of Molecular Sciences, v. 25, (18), September 2024, article number 10142
Kan, Chloe; Ullah, Ata; Dang, Shangyu; Xue, Hong
Article

Parental histone transfer caught at the replication fork

Nature, v. 627, (8005), March 2024, p. 890-897
Li, Ningning; Gao, Yuan; Zhang, Yujie; Yu, Daqi; Lin, JIanwei; Feng, Jiaxuan; Li, Jian; Xu, Zhichun; Zhang, Yingyi; Dang, Shangyu; Zhou, Keda; Liu, Yang; Li, Xiang David; Tye, Bik Kwoon; Li, Qing; Gao, Ning; Zhai, Yuanliang
Article

Ultrapotent class I neutralizing antibodies post Omicron breakthrough infection overcome broad SARS-CoV-2 escape variants

eBioMedicine, v. 108, October 2024, article number 105354
Luo, Mengxiao; Zhou, Runhong; Tang, Bingjie; Liu, Hang; Chen, Bohao; Liu, Na; Mo, Yufei; Zhang, Pengfei; Lee, Ye Lim; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Chan, Wan-Mui; Man, Hiu-On; Chen, Yuting; To, Kelvin Kai-Wang; Yuen, Kwok-Yung; Dang, Shangyu; Chen, Zhiwei
Article

2023 6

ALS-linked C9orf72–SMCR8 complex is a negative regulator of primary ciliogenesis

Proceedings of the National Academy of Sciences of the United States of America, v. 120, (50), December 2023, article number e2220496120
Tang, Dan; Liu, Hang; Dang, Shangyu; Kong, Eryan; Wang, Kunjie; Lu, Kefeng; Qi, Shiqian
Article

Cryo-EM structure of cyanophage P-SCSP1u offers insights into DNA gating and evolution of T7-like viruses

Nature Communications, v. 14, (1), October 2023, article number 6438
Cai, Lanlan; Liu, Hang; Zhang, Wen; Xiao, Shiwei; Zeng, Qinglu; Dang, Shangyu
Article

Cryo-EM structure of TMEM63C suggests it functions as a monomer

Nature Communications, v. 14, (1), November 2023, article number 7265
Qin, Yuqi; Yu, Daqi; Wu, Dan; Dong, Jiangqing; Li, William Thomas; Ye, Chang; Cheung, Kai Chit; Zhang, Yingyi; Xu, Yun; Wang, YongQiang; Shi, Yun Stone; Dang, Shangyu
Article

Menin “reads” H3K79me2 mark in a nucleosomal context

Science, v. 379, (6633), February 2023, p. 717-723
Lin, Jianwei; Wu, Yiping; Tian, Gaofei; Yu, Daqi; Yang, Eunjeong; Lam, Wai Hei; Liu, Zheng; Jing, Yihang; Dang, Shangyu; Bao, Xiucong; Wong, Jason Wing Hon; Zhai, Yuanliang; Li, Xiang David
Article

Synergism between CMG helicase and leading strand DNA polymerase at replication fork

Nature Communications, v. 14, (1), September 2023, article number 5849
Xu, Zhichun; Feng, Jianrong; Yu, Daqi; Huo, Yunjing; Ma, Xiaohui; Lam, Wai Hei; Liu, Zheng; Li, Xiang David; Ishibashi, Toyotaka; Dang, Shangyu; Zhai, Yuanliang
Article

The human pre-replication complex is an open complex

Cell, v. 186, (1), January 2023, p. 98-111
Li, Jian; Dong, Jiangqing; Wang, Weitao; Yu, Daqi; Fan, Xinyu; Hui, Yan Chit; Lee, Clare S.K.; Lam, Wai Hei; Alary, Nathan; Yang, Yang; Zhang, Yingyi; Zhao, Qian; Chen, Chun-Long; Tye yeung, Bik Kwoon; Dang, Shangyu; Zhai, Yuanliang
Article

2022 5

A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge

Nature Communications, v. 13, (1), June 2022, article number 3589
Zhou, Biao; Dang, Shangyu; Tang, Bingjie; Liu, Hang; Chen, Zhiwei
Article

Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria

Environmental Microbiology, v. 24, (7), July 2022, p. 3037-3050
Zhao, Fangxin; Lin, Xingqin; Cai, Kun; Jiang, YongLiang; Ni, Tianchi; Chen, Yue; Feng, Jianrong; Dang, Shangyu; Zhou, Cong-Zhao; Zeng, Qinglu
Article

Recent Technical Advances in Sample Preparation for Single-Particle Cryo-EM

Frontiers in Molecular Biosciences, v. 9, June 2022, article number 892459
Xu, Yixin; Dang, Shangyu
Article

Structural Insight into the MCM Double Hexamer Activation by Dbf4-Cdc7 Kinase

Nature Communications, v. 13, (1), March 2022, article number 1396
Cheng, Jiaxuan; Li, Ningning; Huo, Yunjing; Dang, Shangyu; Tye, Bik Kwoon; Gao, Ning; Zhai, Yuanliang
Article

Application of MSBP improves particle distribution and orientation in single-particle cryo-EM

Dang, Shangyu
Conference paper

2021 1

Application of MSBP improves particle distribution and orientation in single-particle cryo-EM

Dang, Shangyu
Conference paper

2020 1

Structural insights into group II TRP channels

Cell Calcium, v. 86, March 2020, article number 102107
Fine, Michael; Li, Xiaochun; Dang, Shangyu
Article

2019 2

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

Cell Reports, v. 28, (2), July 2019, p. 567-579
Feng, Shengjie; Dang, Shangyu; Han, Tina Wei; Ye, Wen Lei; Jin, Peng; Cheng, Tong; Li, Junrui; Jan, Yuh Nung; Jan, Lily Yeh; Cheng, Yifan
Article

Structural insight into TRPV5 channel function and modulation

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (18), April 2019, p. 8869-8878
Dang, Shangyu; van Goor, Mark K.; Asarnow, Daniel; Wang, YongQiang; Julius, David; Cheng, Yifan; van der Wijst, Jenny
Article

2017 1

Cryo-EM structures of the TMEM16A calciumactivated chloride channel

Nature, v. 552, (7685), December 2017, p. 426-429
Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian Joseph; Bulkley, David P.; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S.; Jan, Yuhnung; Minor, Daniel L.; Cheng, Yifan; Jan, L.Y.
Article

2015 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong
Article

2013 2

Evolutionary mix-and-match with MFS transporters

Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H.
Article

Structure of a presenilin family intramembrane aspartate protease

Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong
Article

2011 1

Structure and mechanism of the uracil transporter UraA

Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng
Article

2010 1

Structure of a fucose transporter in an outward-open conformation

Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng
Article

2009 1

Structure and mechanism of an amino acid antiporter

Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong
Article

Article 1

DNA bending mediated by ORC is essential for replication licensing in budding yeast

Proceedings of the National Academy of Sciences of the United States of America, v. 122, (14), April 2025, article number e2502277122
Lam, Wai Hei; Yu, Daqi; Zhang, Qiongdan; Lin, Yuhan; Li, Ningning; Wu, Yue; Zhang, Yingyi; Gao, Ning; Tye, Bik Kwoon; Zhai, Yuanliang; Dang, Shangyu

Article 4

Metallo-supermolecular branched polymer protects particles from air-water interface in single-particle cryo-electron microscopy

Communications Biology, v. 7, (1), January 2024, article number 65
Xu, Yixin; Qin, Yuqi; Wang, Lang; Zhang, Yingyi; Wang, Yufeng; Dang, Shangyu

Modular Structure and Polymerization Status of GABA_A Receptors Illustrated with EM Analysis and AlphaFold2 Prediction

International Journal of Molecular Sciences, v. 25, (18), September 2024, article number 10142
Kan, Chloe; Ullah, Ata; Dang, Shangyu; Xue, Hong

Parental histone transfer caught at the replication fork

Nature, v. 627, (8005), March 2024, p. 890-897
Li, Ningning; Gao, Yuan; Zhang, Yujie; Yu, Daqi; Lin, JIanwei; Feng, Jiaxuan; Li, Jian; Xu, Zhichun; Zhang, Yingyi; Dang, Shangyu; Zhou, Keda; Liu, Yang; Li, Xiang David; Tye, Bik Kwoon; Li, Qing; Gao, Ning; Zhai, Yuanliang

Ultrapotent class I neutralizing antibodies post Omicron breakthrough infection overcome broad SARS-CoV-2 escape variants

eBioMedicine, v. 108, October 2024, article number 105354
Luo, Mengxiao; Zhou, Runhong; Tang, Bingjie; Liu, Hang; Chen, Bohao; Liu, Na; Mo, Yufei; Zhang, Pengfei; Lee, Ye Lim; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Chan, Wan-Mui; Man, Hiu-On; Chen, Yuting; To, Kelvin Kai-Wang; Yuen, Kwok-Yung; Dang, Shangyu; Chen, Zhiwei

Article 6

ALS-linked C9orf72–SMCR8 complex is a negative regulator of primary ciliogenesis

Proceedings of the National Academy of Sciences of the United States of America, v. 120, (50), December 2023, article number e2220496120
Tang, Dan; Liu, Hang; Dang, Shangyu; Kong, Eryan; Wang, Kunjie; Lu, Kefeng; Qi, Shiqian

Cryo-EM structure of cyanophage P-SCSP1u offers insights into DNA gating and evolution of T7-like viruses

Nature Communications, v. 14, (1), October 2023, article number 6438
Cai, Lanlan; Liu, Hang; Zhang, Wen; Xiao, Shiwei; Zeng, Qinglu; Dang, Shangyu

Cryo-EM structure of TMEM63C suggests it functions as a monomer

Nature Communications, v. 14, (1), November 2023, article number 7265
Qin, Yuqi; Yu, Daqi; Wu, Dan; Dong, Jiangqing; Li, William Thomas; Ye, Chang; Cheung, Kai Chit; Zhang, Yingyi; Xu, Yun; Wang, YongQiang; Shi, Yun Stone; Dang, Shangyu

Menin “reads” H3K79me2 mark in a nucleosomal context

Science, v. 379, (6633), February 2023, p. 717-723
Lin, Jianwei; Wu, Yiping; Tian, Gaofei; Yu, Daqi; Yang, Eunjeong; Lam, Wai Hei; Liu, Zheng; Jing, Yihang; Dang, Shangyu; Bao, Xiucong; Wong, Jason Wing Hon; Zhai, Yuanliang; Li, Xiang David

Synergism between CMG helicase and leading strand DNA polymerase at replication fork

Nature Communications, v. 14, (1), September 2023, article number 5849
Xu, Zhichun; Feng, Jianrong; Yu, Daqi; Huo, Yunjing; Ma, Xiaohui; Lam, Wai Hei; Liu, Zheng; Li, Xiang David; Ishibashi, Toyotaka; Dang, Shangyu; Zhai, Yuanliang

The human pre-replication complex is an open complex

Cell, v. 186, (1), January 2023, p. 98-111
Li, Jian; Dong, Jiangqing; Wang, Weitao; Yu, Daqi; Fan, Xinyu; Hui, Yan Chit; Lee, Clare S.K.; Lam, Wai Hei; Alary, Nathan; Yang, Yang; Zhang, Yingyi; Zhao, Qian; Chen, Chun-Long; Tye yeung, Bik Kwoon; Dang, Shangyu; Zhai, Yuanliang

Article 4

A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge

Nature Communications, v. 13, (1), June 2022, article number 3589
Zhou, Biao; Dang, Shangyu; Tang, Bingjie; Liu, Hang; Chen, Zhiwei

Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria

Environmental Microbiology, v. 24, (7), July 2022, p. 3037-3050
Zhao, Fangxin; Lin, Xingqin; Cai, Kun; Jiang, YongLiang; Ni, Tianchi; Chen, Yue; Feng, Jianrong; Dang, Shangyu; Zhou, Cong-Zhao; Zeng, Qinglu

Recent Technical Advances in Sample Preparation for Single-Particle Cryo-EM

Frontiers in Molecular Biosciences, v. 9, June 2022, article number 892459
Xu, Yixin; Dang, Shangyu

Structural Insight into the MCM Double Hexamer Activation by Dbf4-Cdc7 Kinase

Nature Communications, v. 13, (1), March 2022, article number 1396
Cheng, Jiaxuan; Li, Ningning; Huo, Yunjing; Dang, Shangyu; Tye, Bik Kwoon; Gao, Ning; Zhai, Yuanliang

Conference paper 1

Application of MSBP improves particle distribution and orientation in single-particle cryo-EM

Dang, Shangyu

Conference paper 1

Application of MSBP improves particle distribution and orientation in single-particle cryo-EM

Dang, Shangyu

Article 1

Structural insights into group II TRP channels

Cell Calcium, v. 86, March 2020, article number 102107
Fine, Michael; Li, Xiaochun; Dang, Shangyu

Article 2

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

Cell Reports, v. 28, (2), July 2019, p. 567-579
Feng, Shengjie; Dang, Shangyu; Han, Tina Wei; Ye, Wen Lei; Jin, Peng; Cheng, Tong; Li, Junrui; Jan, Yuh Nung; Jan, Lily Yeh; Cheng, Yifan

Structural insight into TRPV5 channel function and modulation

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (18), April 2019, p. 8869-8878
Dang, Shangyu; van Goor, Mark K.; Asarnow, Daniel; Wang, YongQiang; Julius, David; Cheng, Yifan; van der Wijst, Jenny

Article 1

Cryo-EM structures of the TMEM16A calciumactivated chloride channel

Nature, v. 552, (7685), December 2017, p. 426-429
Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian Joseph; Bulkley, David P.; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S.; Jan, Yuhnung; Minor, Daniel L.; Cheng, Yifan; Jan, L.Y.

Article 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong

Article 2

Evolutionary mix-and-match with MFS transporters

Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H.

Structure of a presenilin family intramembrane aspartate protease

Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong

Article 1

Structure and mechanism of the uracil transporter UraA

Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng

Article 1

Structure of a fucose transporter in an outward-open conformation

Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng

Article 1

Structure and mechanism of an amino acid antiporter

Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong

2019 2

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

Cell Reports, v. 28, (2), July 2019, p. 567-579
Feng, Shengjie; Dang, Shangyu; Han, Tina Wei; Ye, Wen Lei; Jin, Peng; Cheng, Tong; Li, Junrui; Jan, Yuh Nung; Jan, Lily Yeh; Cheng, Yifan
Article

Structural insight into TRPV5 channel function and modulation

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (18), April 2019, p. 8869-8878
Dang, Shangyu; van Goor, Mark K.; Asarnow, Daniel; Wang, YongQiang; Julius, David; Cheng, Yifan; van der Wijst, Jenny
Article

2017 1

Cryo-EM structures of the TMEM16A calciumactivated chloride channel

Nature, v. 552, (7685), December 2017, p. 426-429
Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian Joseph; Bulkley, David P.; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S.; Jan, Yuhnung; Minor, Daniel L.; Cheng, Yifan; Jan, L.Y.
Article

2015 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong
Article

2013 2

Evolutionary mix-and-match with MFS transporters

Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H.
Article

Structure of a presenilin family intramembrane aspartate protease

Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong
Article

2011 1

Structure and mechanism of the uracil transporter UraA

Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng
Article

2010 1

Structure of a fucose transporter in an outward-open conformation

Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng
Article

2009 1

Structure and mechanism of an amino acid antiporter

Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong
Article

Teaching Assignment

LIFS3070	Introduction to Biophysical Instrumentation
LIFS4540	Structure and Function of Proteins
UROP2100O	Undergraduate Research Opportunities Series 2

LIFS2210	Biochemistry I
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS6113H	Current Topics in Biochemistry and Biophysics
SCIE4500	IRE Research Project II
UROP1100N	Undergraduate Research Opportunities Series 1

UROP1100M	Undergraduate Research Opportunities Series 1
UROP2100M	Undergraduate Research Opportunities Series 2

LIFS3070	Introduction to Biophysical Instrumentation
LIFS4540	Structure and Function of Proteins
LIFS4960	Biological Science Capstone Project
LIFS4983	Biotechnology Project Research II
SCIE1500	Guided Study on Research I
SCIE2500	Guided Study on Research II
UROP1100L	Undergraduate Research Opportunities Series 1
UROP3100L	Undergraduate Research Opportunities Series 3

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 13 May 2025)

Current RPGs

Doctor of Philosophy

CHENG, Kefan
Life Science
LI, William Thomas
Life Science
NG, Tin Ying
Life Science
SUN, Zhaowei
Life Science
ZHAO, Xiaolong
Life Science
TANG, Bingjie
Life Science
CHEN, Yan
Life Science
LIU, Hang
Life Science
DENG, Siqi
Life Science
QIN, Yuqi
Life Science
QIU, Qinling
Life Science

Master of Philosophy

SU, Hang
Life Science

Graduated RPGs

Doctor of Philosophy

LIN, Guanzhen
Life Science( Completed in 2025 )

Master of Philosophy

NG, Tin Ying
Life Science( Completed in 2024 )
ZHAO, Xiaolong
Life Science( Completed in 2024 )
TANG, Bingjie
Life Science( Completed in 2023 )
LI, Sirui
Life Science( Completed in 2022 )
LIU, Hang
Life Science( Completed in 2022 )

Projects

From January 2023 to December 2025

Integrative structural and chemical biology approaches to investigate pre-replicative complex assembly and its applications in human diseases

整合結構和化學生物學方法研究人體細胞複製前始複合物的組裝及其在疾病治療中的應用 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
ZHAI Yuanliang (Lead)

DANG Shangyu
2025 -
Biological Cryo-EM

生物冷凍電鏡 Leading

Croucher Foundation
Project Team (HKUST)
DANG Shangyu (Lead)
2025 -
Structural and functional study of SLC26A3, an important anion transporter for sperm capacitation.

精子獲能重要陰離子轉運蛋白SLC26A3的結構和功能研究 Leading

RGC - General Research Fund
Project Team (HKUST)
DANG Shangyu (Lead)
2024 -
Mechanistic study of the defense systems in marine cyanobacteria against bacteriophage infection

海洋藍藻的抗病毒侵染機制 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
ZENG Qinglu (Lead)

DANG Shangyu

GUO Yusong

WANG Jiguang
2023 -
Probing structure-function relationship of TMIE in auditory mechanotransduction using in vitro and in vivo assays

利用體外和體內方法探索TMIE在聽覺轉導中的結構和功能關係 Participating

RGC - General Research Fund
Project Team (HKUST)
HUANG Pingbo (Lead)

DANG Shangyu
2023 -
Molecular mechanism of phosphate transporter in bacteria to tackle phosphorus scarcity

細菌中磷酸鹽轉運蛋白解決磷缺乏的分子機制 Leading

RGC - General Research Fund
Project Team (HKUST)
DANG Shangyu (Lead)
2023 -
IAS Symposium on Biological Cryo-EM Leading

Croucher Foundation
Project Team (HKUST)
DANG Shangyu (Lead)
2023 - 2023
In situ investigation of cellular ultrastructures and biological macromolecules using correlative light and electron microscopy and cryo-electron tomography

利用光電關聯顯微技術和超低溫電子斷層掃描技術研究細胞顯微結構及生物大分子原位結構 Leading

RGC - Collaborative Research Fund
Project Team (HKUST)
DANG Shangyu (Lead)

TONG Penger

WU Zhenguo

XIE Ting

ZENG Qinglu
2022 -
Mechanism for the TMEM63B mechanosensitive ion channel, an osmosensor required for hearing

對機械敏感離子通道TMEM63B作為聽力所需滲透傳感器的機制研究 Leading

RGC - General Research Fund
Project Team (HKUST)
DANG Shangyu (Lead)
2022 - 2024
Structure and molecular mechanisms of the eukaryotic replisome

真核生物複製機器的結構和分子機制研究 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
DANG Shangyu
2021 - 2024
Application of gel-like branched polymer to improve particle distribution and orientation in single-particle cryo-EM

利用凝膠狀支鏈聚合物改善單顆粒冷凍電子顯微技術中顆粒的分布與取向 Leading

Shenzhen Science and Technology Innovation Strategy Research and Technology Transfer Promotion Center
Project Team (HKUST)
DANG Shangyu (Lead)
2021 - 2023
Mechanism study of ABHD2, a key regulatory protein of sperm hyperactivated motility

精子超活化運動關鍵調控蛋白ABHD2的機理研究 Leading

Guangdong Natural Science Foundation
Project Team (HKUST)
DANG Shangyu (Lead)

FENG Jianrong
2021 - 2023

Research Interest

Publications

2025 1

2024 4

2023 6

2022 5

2021 1

2020 1

2019 2

2017 1

2015 1

2013 2

2011 1

2010 1

2009 1

Article 1

Article 4

Article 6

Article 4

Conference paper 1

Conference paper 1

Article 1

Article 2

Article 1

Article 1

Article 2

Article 1

Article 1

Article 1

2019 2

2017 1

2015 1

2013 2

2011 1

2010 1

2009 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 13 May 2025)

Current RPGs

Graduated RPGs

Projects

From January 2023 to December 2025

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