Faculty Profiles - DANG Shangyu | The Hong Kong University of Science and Technology

Shangyu DANG
黨尚宇

Doctor of Natural Science in Biology
Tsinghua University, 2014

Assistant Professor
Division of Life Science

ORCID

0000-0001-9141-1865

Scopus ID

26655423700

Research Interest

Structural biology
Deoxyribonucleic acid (DNA) replication
Protein-DNA complexes
Calcium signaling
Electron microscopy
Disease mechanisms
Proteins

Publications

2023 2

Menin “reads” H3K79me2 mark in a nucleosomal context

Science, v. 379, (6633), February 2023, p. 717-723
Lin, Jianwei; Wu, Yiping; Tian, Gaofei; Yu, Daqi; Yang, Eunjeong; Lam, Wai Hei; Liu, Zheng; Jing, Yihang; Dang, Shangyu; Bao, Xiucong; Wong, Jason Wing Hon; Zhai, Yuanliang; Li, Xiang David
Article

The human pre-replication complex is an open complex

Cell, v. 186, (1), 5 January 2023, p. 98-111
Li, Jian; Dong, Jiangqing; Wang, Weitao; Yu, Daqi; Fan, Xinyu; Hui, Yan Chit; Lee, Clare S.K.; Lam, Wai Hei; Alary, Nathan; Yang, Yang; Zhang, Yingyi; Zhao, Qian; Chen, Chun-Long; Tye Yeung, Bik Kwoon; Dang, Shangyu; Zhai, Yuanliang
Article

2022 5

A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge

Nature Communications, v. 13, (1), June 2022, article number 3589
Zhou, Biao; Dang, Shangyu; Tang, Bingjie; Liu, Hang; Chen, Zhiwei
Article

Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria

Environmental Microbiology, May 2022
Zhao, Fangxin; Lin, Xingqin; Cai, Kun; Jiang, YongLiang; Ni, Tianchi; Chen, Yue; Feng, Jianrong; Dang, Shangyu; Zhou, Cong-Zhao; Zeng, Qinglu
Article

Recent Technical Advances in Sample Preparation for Single-Particle Cryo-EM

Frontiers in Molecular Biosciences, v. 9, June 2022, article number 892459
Xu, Yixin; Dang, Shangyu
Article

Structural Insight into the MCM Double Hexamer Activation by Dbf4-Cdc7 Kinase

Nature Communications, v. 13, (1), March 2022, article number 1396
Cheng, Jiaxuan; Li, Ningning; Huo, Yunjing; Dang, Shangyu; Tye, Bik Kwoon; Gao, Ning; Zhai, Yuanliang
Article

Application of MSBP improves particle distribution and orientation in single-particle cryo-EM

Dang, Shangyu
Conference paper

2021 1

Application of MSBP improves particle distribution and orientation in single-particle cryo-EM

Dang, Shangyu
Conference paper

2020 1

Structural insights into group II TRP channels

Cell Calcium, v. 86, March 2020, article number 102107
Fine, Michael; Li, Xiaochun; Dang, Shangyu
Article

2019 2

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

Cell Reports, v. 28, (2), July 2019, p. 567-579
Feng, Shengjie; Dang, Shangyu; Han, Tina Wei; Ye, Wen Lei; Jin, Peng; Cheng, Tong; Li, Junrui; Jan, Yuh Nung; Jan, Lily Yeh; Cheng, Yifan
Article

Structural insight into TRPV5 channel function and modulation

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (18), April 2019, p. 8869-8878
Dang, Shangyu; van Goor, Mark K.; Asarnow, Daniel; Wang, YongQiang; Julius, David; Cheng, Yifan; van der Wijst, Jenny
Article

2017 1

Cryo-EM structures of the TMEM16A calciumactivated chloride channel

Nature, v. 552, (7685), December 2017, p. 426-429
Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian Joseph; Bulkley, David P.; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S.; Jan, Yuhnung; Minor, Daniel L.; Cheng, Yifan; Jan, L.Y.
Article

2015 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong
Article

2013 2

Evolutionary mix-and-match with MFS transporters

Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H.
Article

Structure of a presenilin family intramembrane aspartate protease

Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong
Article

2011 1

Structure and mechanism of the uracil transporter UraA

Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng
Article

2010 1

Structure of a fucose transporter in an outward-open conformation

Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng
Article

2009 1

Structure and mechanism of an amino acid antiporter

Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong
Article

Article 2

Menin “reads” H3K79me2 mark in a nucleosomal context

Science, v. 379, (6633), February 2023, p. 717-723
Lin, Jianwei; Wu, Yiping; Tian, Gaofei; Yu, Daqi; Yang, Eunjeong; Lam, Wai Hei; Liu, Zheng; Jing, Yihang; Dang, Shangyu; Bao, Xiucong; Wong, Jason Wing Hon; Zhai, Yuanliang; Li, Xiang David

The human pre-replication complex is an open complex

Cell, v. 186, (1), 5 January 2023, p. 98-111
Li, Jian; Dong, Jiangqing; Wang, Weitao; Yu, Daqi; Fan, Xinyu; Hui, Yan Chit; Lee, Clare S.K.; Lam, Wai Hei; Alary, Nathan; Yang, Yang; Zhang, Yingyi; Zhao, Qian; Chen, Chun-Long; Tye Yeung, Bik Kwoon; Dang, Shangyu; Zhai, Yuanliang

Article 4

A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge

Nature Communications, v. 13, (1), June 2022, article number 3589
Zhou, Biao; Dang, Shangyu; Tang, Bingjie; Liu, Hang; Chen, Zhiwei

Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria

Environmental Microbiology, May 2022
Zhao, Fangxin; Lin, Xingqin; Cai, Kun; Jiang, YongLiang; Ni, Tianchi; Chen, Yue; Feng, Jianrong; Dang, Shangyu; Zhou, Cong-Zhao; Zeng, Qinglu

Recent Technical Advances in Sample Preparation for Single-Particle Cryo-EM

Frontiers in Molecular Biosciences, v. 9, June 2022, article number 892459
Xu, Yixin; Dang, Shangyu

Structural Insight into the MCM Double Hexamer Activation by Dbf4-Cdc7 Kinase

Nature Communications, v. 13, (1), March 2022, article number 1396
Cheng, Jiaxuan; Li, Ningning; Huo, Yunjing; Dang, Shangyu; Tye, Bik Kwoon; Gao, Ning; Zhai, Yuanliang

Conference paper 1

Application of MSBP improves particle distribution and orientation in single-particle cryo-EM

Dang, Shangyu

Conference paper 1

Application of MSBP improves particle distribution and orientation in single-particle cryo-EM

Dang, Shangyu

Article 1

Structural insights into group II TRP channels

Cell Calcium, v. 86, March 2020, article number 102107
Fine, Michael; Li, Xiaochun; Dang, Shangyu

Article 2

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

Cell Reports, v. 28, (2), July 2019, p. 567-579
Feng, Shengjie; Dang, Shangyu; Han, Tina Wei; Ye, Wen Lei; Jin, Peng; Cheng, Tong; Li, Junrui; Jan, Yuh Nung; Jan, Lily Yeh; Cheng, Yifan

Structural insight into TRPV5 channel function and modulation

Proceedings of the National Academy of Sciences of the United States of America, v. 116, (18), April 2019, p. 8869-8878
Dang, Shangyu; van Goor, Mark K.; Asarnow, Daniel; Wang, YongQiang; Julius, David; Cheng, Yifan; van der Wijst, Jenny

Article 1

Cryo-EM structures of the TMEM16A calciumactivated chloride channel

Nature, v. 552, (7685), December 2017, p. 426-429
Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian Joseph; Bulkley, David P.; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S.; Jan, Yuhnung; Minor, Daniel L.; Cheng, Yifan; Jan, L.Y.

Article 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong

Article 2

Evolutionary mix-and-match with MFS transporters

Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H.

Structure of a presenilin family intramembrane aspartate protease

Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong

Article 1

Structure and mechanism of the uracil transporter UraA

Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng

Article 1

Structure of a fucose transporter in an outward-open conformation

Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng

Article 1

Structure and mechanism of an amino acid antiporter

Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong

2017 1

Cryo-EM structures of the TMEM16A calciumactivated chloride channel

Nature, v. 552, (7685), December 2017, p. 426-429
Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian Joseph; Bulkley, David P.; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S.; Jan, Yuhnung; Minor, Daniel L.; Cheng, Yifan; Jan, L.Y.
Article

2015 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong
Article

2013 2

Evolutionary mix-and-match with MFS transporters

Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H.
Article

Structure of a presenilin family intramembrane aspartate protease

Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong
Article

2011 1

Structure and mechanism of the uracil transporter UraA

Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng
Article

2010 1

Structure of a fucose transporter in an outward-open conformation

Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng
Article

2009 1

Structure and mechanism of an amino acid antiporter

Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong
Article

No Publications

Teaching Assignment

LIFS3070	Introduction to Biophysical Instrumentation
LIFS4540	Structure and Function of Proteins
SCIE2500	Guided Study on Research II
SCIE4500	IRE Research Project II

LIFS2210	Biochemistry I
LIFS4960	Biological Science Capstone Project
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS6113F	Current Topics in Biochemistry and Biophysics

LIFS3070	Introduction to Biophysical Instrumentation
LIFS4540	Structure and Function of Proteins
LIFS4981	Biochemistry and Cell Biology Project Research II

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2020 to December 2023 (As of 28 May 2023)

Current RPGs

Doctor of Philosophy

CHEN, Yan
Life Science
LIU, Hang
Life Science
DENG, Siqi
Life Science
QIN, Yuqi
Life Science
QIU, Qinling
Life Science

Master of Philosophy

NG, Tin Ying
Life Science
ZHAO, Xiaolong
Life Science
TANG, Bingjie
Life Science

Graduated RPGs

Master of Philosophy

LI, Sirui
Life Science( Completed in 2022 )
LIU, Hang
Life Science( Completed in 2022 )
XU, Yixin
Life Science( Completed in 2021 )

Projects

From January 2021 to December 2023

Mechanistic study of the defense systems in marine cyanobacteria against bacteriophage infection

海洋藍藻的抗病毒侵染機制 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
ZENG Qinglu (Lead)

DANG Shangyu

GUO Yusong

WANG Jiguang
2023 -
Molecular mechanism of phosphate transporter in bacteria to tackle phosphorus scarcity

細菌中磷酸鹽轉運蛋白解決磷缺乏的分子機制 Leading

RGC - General Research Fund
Project Team (HKUST)
DANG Shangyu (Lead)
2023 -
IAS Symposium on Biological Cryo-EM Leading

Croucher Foundation
Project Team (HKUST)
DANG Shangyu (Lead)
2023 -
In situ investigation of cellular ultrastructures and biological macromolecules using correlative light and electron microscopy and cryo-electron tomography

利用光電關聯顯微技術和超低溫電子斷層掃描技術研究細胞顯微結構及生物大分子原位結構 Leading

RGC - Collaborative Research Fund
Project Team (HKUST)
DANG Shangyu (Lead)

TONG Penger

WU Zhenguo

XIE Ting

ZENG Qinglu
2022 -
Mechanism for the TMEM63B mechanosensitive ion channel, an osmosensor required for hearing

對機械敏感離子通道TMEM63B作為聽力所需滲透傳感器的機制研究 Leading

RGC - General Research Fund
Project Team (HKUST)
DANG Shangyu (Lead)
2022 -
Structure and molecular mechanisms of the eukaryotic replisome

真核生物複製機器的結構和分子機制研究 Participating

RGC - Collaborative Research Fund
Project Team (HKUST)
DANG Shangyu
2021 -
Application of gel-like branched polymer to improve particle distribution and orientation in single-particle cryo-EM

利用凝膠狀支鏈聚合物改善單顆粒冷凍電子顯微技術中顆粒的分布與取向 Leading

Shenzhen Science and Technology Innovation Strategy Research and Technology Transfer Promotion Center
Project Team (HKUST)
DANG Shangyu (Lead)
2021 -
Mechanism study of ABHD2, a key regulatory protein of sperm hyperactivated motility

精子超活化運動關鍵調控蛋白ABHD2的機理研究 Leading

Guangdong Natural Science Foundation
Project Team (HKUST)
DANG Shangyu (Lead)
2021 -
Investigation of calcium signaling in sperm cells

精子細胞中鈣信號的研究 Leading

RGC - Early Career Scheme
Project Team (HKUST)
DANG Shangyu (Lead)
2020 - 2022

Research Interest

Publications

2023 2

2022 5

2021 1

2020 1

2019 2

2017 1

2015 1

2013 2

2011 1

2010 1

2009 1

Article 2

Article 4

Conference paper 1

Conference paper 1

Article 1

Article 2

Article 1

Article 1

Article 2

Article 1

Article 1

Article 1

2017 1

2015 1

2013 2

2011 1

2010 1

2009 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2020 to December 2023 (As of 28 May 2023)

Current RPGs

Graduated RPGs

Projects

From January 2021 to December 2023

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