Faculty Profiles - KO Robert Kam Ming | The Hong Kong University of Science and Technology

2024 2

Pharmacological Investigation on the Qi-Invigorating Action of Schisandrin B: Effects on Mitochondrial ATP Generation in Multiple Tissues and Innate/Adaptive Immunity in Mice

Chinese Medicine, v. 15, (2), June 2024, p. 15-26
Leung, Hoi Yan; Sze, Suen Chit; Ko, Robert Kam Ming
Article

The Essential Role of Zheng Qi in Promoting Health: From the Perspective of Chinese Medicine and Modern Medicine

Chinese Medicine, v. 15, (2), June 2024, p. 27-33
Ko, Robert Kam Ming; Leung, Hoi Yan
Article

2023 4

A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

Chinese Medicine, v. 14, (4), December 2023, p. 242-254
Xia, Zumeng; Leung, Hoi Yan; Siu, Hoi Ling Ada; Chan, Chung Wai; Ko, Kam Ming
Article

Cell-Based Biological Markers for Blood-Enriching Chinese Herbs: Erythropoietin Production in HepG2 Cells and Nitric Oxide Release in Human Umbilical Vein Endothelial Cells (HUVECs)

Chinese Medicine, v. 14, (2), June 2023, p. 57-67
Leung, Hoi Yan; Ko, Kam Ming
Article

Differential Effects of Yin- and Yang-Chinese Tonifying Herbs on Innate and Adaptive Immunity

Chinese Medicine, v. 14, (2), June 2023, p. 68-78
Leung, Hoi Yan; Ko, Kam Ming
Article

Exploring the possible mechanism(s) underlying the nephroprotective effect of Zhenwu Decoction in diabetic kidney disease: An integrated analysis

Phytomedicine, v. 119, October 2023, article number 154988
Liu, Zhihao; Shang, Qixiang; Li, Haimeng; Fang, Daozheng; Li, Zhuohuan; Huang, Yuqi; Zhang, Mimi; Ko, Kam Ming; Chen, Jihang
Article

2022 1

Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice

Asian Pacific Journal of Tropical Biomedicine, v. 12, (2), February 2022, p. 59-68
Pan, Si-Yuan; Song, Xue-Lan; Lin, Zhao-Heng; Yu, Qing; Zhang, Yi; Tai, Ha-Chuan; Luo, Gan; Wang, Xiao-Yan; Zhu, Pei-Li; Sun, Nan; Chu, Zhu-Sheng; Yu, Zhi-Ling; Zhang, Yi; Ko, Kam Ming
Article

2021 4

Antioxidant and Immunopotentiating Effects of Cordyceps Mycelium Extract, Chicken Essence, and Their Combination in Experimental Models

Chinese Medicine, v. 12, (1), March 2021, p. 1-9
Leung, Hoi Yan; Yan, Choly Tat Ming; Ko, Kam Ming
Article

Differential Effects of Ursolic Acid and Oleanolic Acid on Mitochondrial ATP Generation in H9c2 Cardiomyocytes and Lipopolysaccharide-Induced Cell Proliferation in Mouse Splenocytes: Yang versus Yin

Chinese Medicine, v. 12, (3), September 2021, article number 11694, p. 37-46
Leung, Hoi Yan; Cheung, Kai Kit; Ko, Kam Ming
Article

Evaluation of Beneficial and Adverse Effects of a Diet Supplemented with Schisandrae Fructus Seed Ethanol Extract on Lipid and Glucose Metabolism in Normal and Hypercholesterolemic/Hyperglycemic Mice

Evidence-based Complementary and Alternative Medicine, v. 2021, February 2021, article number 8858962
Wang, Xiao-Yan; Song, Xue-Lan; Zhang, Yi; Luo, Gan; Tai, Hai-Chuan; Lin, Zhao-Heng; Zhu, Pei-Li; Sun, Nan; Chu, Zhu-Sheng; Yu, Zhi-Ling; Pan, Si-Yuan; Tang, Jin-Fa; Ko, Kam Ming
Article

The Use of Chinese Yang/Qi-Invigorating Tonic Botanical Drugs/Herbal Formulations in Ameliorating Chronic Kidney Disease by Enhancing Mitochondrial Function

Frontiers in Pharmacology, v. 12, 24 June 2021, article number 622498
Tian, Jiayi; Huang, Yuqi; Wu, Tong; Huang, Hsien-Da; Ko, Kam Ming; Zhu, Bao Ting; Chen, Jihang
Article

2020 4

48Biochemical Mechanisms of the Anti-Obesity Effect of a Triterpenoid-Enriched Extract of Cynomorium Songaricum in Mice With High-Fat-Diet-Induced Obesity

Phytomedicine, v. 73, July 2020, article number 153038
Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Wong, Hoi Shan; Ko, Robert Kam Ming
Article

A unifying theory of aging between modern medicine and traditional Chinese medicine

Chinese Medicine, v. 11, (2), June 2020, p. 105-112
Cheung, Kai Chit; Leung, Hoi Yan; Ko, Robert Kam Ming
Article

Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma

Molecules, v. 25, (18), September 2020, article number 4051
Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Leong, Pou Kuan; Yan, Choly Tat Ming; Ko, Kam Ming
Article

Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways

FASEB Journal, v. 34, (3), March 2020, p. 4311-4328
Yu, Xiaodan; Xu, Li Miranda; Yao, Ping; Kwan, Kin Leung; Liu, Yongxiang; Duan, Ran; Dong Ting Xia; Ko, Kam Ming; Tsim, Karl Wah Keung
Article

2019 6

A Chinese Herbal Formulation, Xiao-Er-An-Shen Decoction, Attenuates Tourette Syndrome, Possibly by Reversing Abnormal Changes in Neurotransmitter Levels and Enhancing Antioxidant Status in Mouse Brain

Frontiers in Pharmacology, v. 10, July 2019, article number 812
Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Li, Zhonggui; Qiu, Jingyu; Ko, Kam Ming; Chen, Jianping
Article

Pharmacological Investigation of “Meridian Tropism” in Three “Shen” Chinese Herbs

Chinese Medicine, v. 10, (4), December 2019, p. 121-135
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming
Article

Yang/Qi-invigorating herbs for the prevention and/or treatment of diabetic complications

Longhua Chinese Medicine, v. 2, March 2019, article number 4
Leong, Pou Kuan; Ko, Robert Kam Ming
Article

基于脂质代谢组学评价五味子素B诱导的急性高甘油三酯血症小鼠模型

中国药理学通报=Chinese Pharmacological Bulletin, v. 35, (6), 2019, p. 833-839
王晓艳; 储著胜; 张辉; 张书琦; 潘思源; 唐进法; 高锦明
Article

Biomarkers for quality control of Chinese tonifying herbs and herbal health products

Natural Medicines: Clinical Efficacy, Safety and Quality / Edited by Dilip Ghosh, Pulok K. Mukherjee. Boca Raton : CRC Press, 2019, p. 127-137, Ch. 7
Leong, Pou Kuan; Ko, Kam Ming
Book chapter

Corylin induces bone differentiation and metabolic profiling: illustration by using cultured osteoblasts and bone micromass

Yu, Xiaodan; Xu, Li; Yao, Ping; Kwan, Kin Leung; Liu, Yongxiang; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung
Conference paper

2018 5

Differences in the mechanisms by which Yang-invigorating and Qi-invigorating Chinese tonifying herbs stimulate mitochondrial ATP generation capacity

Chinese Medicine, v. 9, (2), 2018, p. 63-74
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming
Article

Shengmai San: a modern medicine perspective on its remedial effects on Qi and Yin deficiency syndrome in Chinese medicine

Longhua Chinese Medicine, v. 1, 20 September 2018, article number 13
Leong, Pou Kuan; Ko, Robert Kam Ming
Article

Development of Chinese Herbal Health Products for the Prevention of Aging-Associated Diseases

Natural Products and Drug Discovery: An Integrated Approach / Edited by: Subhash C. Mandal, Vivekananda Mandal and Tetsuya Konishi. Elsevier, 2018, p. 73-104, Ch. 4
Leong, Pou Kuan; Chen, Jihang; Ko, Robert Kam Ming
Book chapter

Corylin induced the differentiation, mineralization and metabolic activity in rat osteoblasts and micromass cultures

Yu, Xiaodan; Xu, Li; Yao, Ping; Dai, Kun; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung
Conference paper

Stimulatory effects of corylin on differentiation, mineralization and metabolic activity in rat osteoblasts and micromass cultures

Yu, Xiaodan; Xu, Li; Yao, Ping; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung
Conference paper

2017 4

Acute Pre-/Post-Treatment with 8th Day SOD-Like Supreme (a Free Radical Scavenging Health Product) Protects against Oxidant-Induced Injury in Cultured Cardiomyocytes and Hepatocytes In Vitro as Well as in Mouse Myocardium and Liver In Vivo

Antioxidants, v. 6, (2), June 2017, article number 28
Leong, Pou Kuan; Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Chan, Lincoln; Ko, Kam Ming
Article

Biochemical Mechanism Underlying Hypertriglyceridemia and Hepatic Steatosis/Hepatomegaly Induced by Acute Schisandrin B Treatment in Mice

Lipids in Health and Disease, v. 16, (1), January 2017, p. 1-15
Zhang, Yi; Zhao, Jing; Zhou, Shufeng; Yu, Zhiling; Wang, Xiaoyan; Zhu, Peili; Chu, Zhusheng; Pan, Siyuan; Xie, Ming; Ko, Kamming
Article

Inter-organ relationships among gut, lung and skin beyond the pathogenesis of allergies: Relevance to the Zang-Fu Theory in Chinese medicine

Chinese Medicine, v. 8, (3), 2017, article number 78205, p. 73-81
Leung, Hiu Yu Cherie; Leong, Pou Kuan; Chen, Jihang; Ko, Robert Kam Ming
Article

Ursolic Acid Induces Mitochondrial Biogenesis Through the Activation of AMPK and PGC-1 in C2C12 myotubes: A possible Mechanism Underlying its Beneficial Effect on Exercise Endurance

Food and Function, v. 8, (7), 2017, p. 2425-2436
Chen, Jihang; Wong, Hoi Shan; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wingman; Ko, Robert K M
Article

2016 7

A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration

PLoS One, v. 11, (3), March 2016, article number e0149663
Zhang, Liyun; Xiang, Lue; Liu, Yiwen; Venkatraman, Prahatha; Chong, Leelyn; Cho, Jin; Bonilla, Sylvia; Jin, Zi-Bing; Pang, Chi Pui; Ko, Kam Ming; Ma, Ping; Zhang, Mingzhi; Leung, Yuk Fai
Article

An Herbal Formula (GPC) Suppresses the Releases of Pro-Inflammatory Effectors in Lipopolysaccharide/Peptidoglycan-Activated RAW264.7 Macrophages and Reduces the Extent of Chemical-Induced Acute/Chronic Inflammation in Rodents

Chinese Medicine, v. 7, December 2016, p. 153-165
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Chen, Jihang; Zhu, Huawei; Ning, Jialing; Yang, Yiting; Ma, Chung Wah; Ko, Robert Kam Ming
Article

Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response

PLoS ONE, v. 11, (5), May 2016, article number e0155879
Leong, Pou Kuan; Wong, Hoi Shan; Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Ko, Kam Ming
Article

Induction of the Glutathione Antioxidant Response/Glutathione Redox Cycling by Nutraceuticals: Mechanism of Protection against Oxidant-induced Cell Death

Current Trends in Nutraceuticals, v. 1, (1-2), March 2016, p. 1-9
Leong, Pou Kuan; Ko, Robert Kam Ming
Article

Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease

Oxidative Medicine and Cellular Longevity, v. 2016, October 2016, article number 6171658
Leong, Pou Kuan; Ko, Kam Ming
Article

Spleen Function and Anxiety in Chinese Medicine: A Western Medicine Perspective

Chinese Medicine, v. 7, (3), August 2016
Chung, Yin Kwan; Chen, Jihang; Ko, Robert Kam Ming
Article

β-Sitosterol increases mitochondrial electron transport by fluidizing mitochondrial membranes and enhances mitochondrial responsiveness to increasing energy demand by the induction of uncoupling in C2C12 myotubes

Journal of Functional Foods, v. 23, May 2016, p. 253-260
Wong, Hoi Shan; Leong, Pou Kuan; Chen, Jihang; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M.
Article

2015 17

A cistanches herba fraction/ β -sitosterol causes a redox-sensitive induction of mitochondrial uncoupling and activation of adenosine monophosphate-dependent protein kinase/peroxisome proliferator-activated receptor γ coactivator-1 in C2C12 myotubes: A possible mechanism underlying the weight reduction effect

Evidence-based Complementary and Alternative Medicine, v. 2015, 2015, article number 142059
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Kam Ming
Article

A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice

Lipids in Health and Disease, v. 14, (1), August 2015, article number 97
Chu, Zhusheng; Yu, Zhiling; Pan, Siyuan; Jia, Zhanhong; Wang, Xiaoyan; Zhang, Yi; Zhu, Peili; Wang, Xiujuan; Ko, Kamming
Article

A traditional Chinese medicine approach in treating depression by promoting liver Qi circulation: A western medicine perspective

Chinese Medicine, v. 6, (4), November 2015, p. 187-195
So, Raphaella Wai Lam; Wong, Hoi Shan; Ko, Robert K.M.
Article

Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice

Drug Design, Development and Therapy, v. 9, February 2015, p. 923-935
Zhu, Pei-Li; Pan, Si-Yuan; Zhou, Shu-Feng; Zhang, Yi; Wang, Xiao-Yan; Sun, Nan; Chu, Zhu-Sheng; Yu, Zhi-Ling; Ko, Kam-Ming
Article

Evaluation of a topical herbal agent for the promotion of bone healing

Evidence-based Complementary and Alternative Medicine, v. 2015, February 2015, article number 905270
Siu, Wingsum; Ko, Chunhay; Lam, Ka Wing; Wat, Elaine C.L.; Shum, Waiting; Lau, Clara; Ko, Kam Ming; Hung, Leung Kim; Lau, David Tai Wai; Leung, Pingchung
Article

Hawthorn Nectar Enhances Gastrointestinal Motility as Well as Stimulates Intestinal Amylase and Lipase Activities in Mice

Chinese Medicine, v. 6, September 2015, article number 59435, p. 159-168
Zou, Shiyu; Li, Jiangping; Ma, Chungwah; Chen, Jihang; Leong, Poukuan; Leung, Hoiyan; Chan, Wingman; Wong, Hoi Shan; Ko, Robert K.M.
Article

Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry

Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan
Article

Lily bulb nectar produces expectorant and anti-tussive activities, and suppresses cigarette smoke-induced inflammatory response in the respiratory tract in mice

Chinese Medicine, v. 6, June 2015, article number 56861, p. 136-146
Wong, Hoi Shan; Zou, Shiyu; Li, Jiangping; Ma, Chungwah; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M.
Article

Mitochondrial reactive oxygen species production mediates ursolic acid-induced mitochondrial uncoupling and glutathione redox cycling, with protection against oxidant injury in H9c2 cells

Food and Function, v. 6, (2), February 2015, p. 549-557
Chen, Jihang; Wong, Hoi Shan; Ko, Kam Ming
Article

New perspectives on dietary-derived treatments and food safety – Antinomy in a new era

Critical Reviews in Food Science and Nutrition, v. 55, (13), November 2015, p. 1836-1859
Pan, Si-Yuan; Gao, Si-Hua; Lin, Rui-Chao; Zhou, Shu-Feng; Dong, Hong-Guan; Tang, Min-Ke; Yu, Zhi-Ling; Ko, Robert K.M.
Article

Schisandrin B Ameliorates ICV-Infused Amyloid beta Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-kappa B/MAPK and Up-Regulating HSP/Beclin Expression

PLoS One, v. 10, (11), November 2015, article number e0142483
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Arumugam, Somasundaram; Mizuno, Makoto; Nawa, Hiroyuki; Suzuki, Kenji; Ko, Robert K.M.; Krishnamurthy, Prasanna; Watanabe, Kenichi; Konishi, Tetsuya
Article

Schisandrin B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo

BioFactors, v. 41, (5), September 2015, p. 314-323
Leong, Pou-Kuan; Ko, Kam-Ming
Article

Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: Implications for its hepatotoxicity

Drug Design, Development and Therapy, v. 9, April 2015, p. 2001-2027
Zhang, Yi; Zhou, Zhiwei; Jin, Hua; Hu, Chengbin; He, Zhixu; Yu, Zhiling; Ko, Robert K.M.; Yang, Tianxin; Zhang, Xueji; Pan, Siyuan; Zhou, Shufeng
Article

Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling

PLoS ONE, v. 10, (3), March 2015, article number e0119214
Thandavarayan, Rajarajan A.; Giridharan, Vijayasree V.; Arumugam, Somasundaram; Suzuki, Kenji; Ko, Kam Ming; Krishnamurthy, Prasanna; Watanabe, Kenichi; Konishi, Tetsuya
Article

Yang/Qi invigoration: An herbal therapy for chronic fatigue syndrome with yang deficiency?

Evidence-based Complementary and Alternative Medicine, v. 2015, 2015, article number 945901
Leong, Pou Kuan; Wong, Hoi Shan; Chen, Jihang; Ko, Kam Ming
Article

Schisandra Chinensis: An Herb of North Eastern China Origin

Ko, Kam Ming; Yin, Jun; Qin, Chuixin
Book

An investigation of anti-inflammatory activities produced by schisandrin A and schisandrin B in vitro and in vivo

Leong, Pou Kuan; Ko, Robert K.M.
Conference paper

2014 17

Acute and Long-term Treatment with an Herbal Formula V-Vital Capsule Increase Exercise Endurance Capacity in Weight-loaded Swimming Mice

Chinese Medicine, v. 5, (3), September 2014, p. 153-164
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Chen, Ji Hang; Wong, Hoi Shan; Ma, Chung Wah; Zou, Shi Yu; Ko, Robert K.M.
Article

An ursolic acid-enriched Cynomorium songarium extract attenuates high fat diet-induced obesity in mice possibly through mitochondrial uncoupling

Journal of Functional Foods, v. 9, July 2014, p. 211-224
Chen, Jihang; Wong, Hoi Shan; Leung, Hoi Yan; Leong, Pou Kuan; Chan, Wing Man; Ko, Robert Kam Ming
Article

An ursolic acid-enriched extract of Cynomorium songaricum protects against carbon tetrachloride hepatotoxicity and gentamicin nephrotoxicity in rats possibly through a mitochondrial pathway: A comparison with ursolic acid

Journal of Functional Foods, v. 7, (1), 2014, p. 330-341
Chen, Jihang; Wong, Hoi Shan; Leung, Hoi Yan; Leong, Pou Kuan; Chan, Wing Man; Chen, Na; Ko, Kam Ming
Article

Cistanches Herba reduces the weight gain in high fat diet-induced obese mice possibly through mitochondrial uncoupling

Journal of Functional Foods, v. 10, September 2014, p. 292-304
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M.
Article

Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet

Lipids in Health and Disease, v. 13, (1), March 2014, article number 46
Sun, Nan; Pan, Si-Yuan; Zhang, Yi; Wang, Xiao-Yan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Zhou, Shu-Feng; Ko, Robert K M
Article

Historical Perspective of Traditional Indigenous Medical Practices: The Current Renaissance and Conservation of Herbal Resources

Evidence-based Complementary and Alternative Medicine, v. 2014, 2014, article number 525340
Pan, Si-Yuan; Litscher, Gerhard; Gao, Si-Hua; Zhou, Shu-Feng; Yu, Zhi-Ling; Chen, Hou-Qi; Zhang, Shuo-Feng; Tang, Min-Ke; Sun, Jian-Ning; Ko, Kam-Ming
Article

Long-term Treatment with an Herbal Formula MCC Ameliorates Obesity-associated Metabolic Dysfunction in High Fat Diet-induced Obese Mice: a Comparative Study among MCC and Various Combinations of its Constituents

Chinese Medicine, v. 5, (1), March 2014, article number 44280, p. 34-46
Leong, Pou Kuan; Leung, Hoi Yan; Wong, Hoi Shan; Chen, Jihang; Chan, Wing Man; Ma, Chung Wah; Yang, Yi Ting; Ko, Robert K.M.
Article

New insights into the chemical and biochemical basis of the "yang-invigorating" action of chinese yang-tonic herbs

Evidence-based Complementary and Alternative Medicine, v. 2014, December 2014, article number 856273
Chen, Jihang; Wong, Hoi Shan; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Kam Ming
Article

Quality Assurance of Chinese Herbal Medicines: Procedure for Multiple-Herb Extraction

AIChE journal, v. 60, (12), December 2014, p. 4014-4026
Lau, Yeuk Tin; Ng, Ka Ming; Chen, Na; Lau, David T.W.; Ko, Robert K.M.; Leung, Ping Chung; Wibowo, Christianto
Article

Schisandrin B enhances glutathione redox cycling and protects against β-amyloid-induced apoptosis in human neuroblastoma SH-SY5Y cells: A comparative study of various phytochemicals

The Open Nutraceuticals Journal, v. 7, (1), December 2014 , p. 49-57
Leong, Pou Kuan; Lam,Yeung; Chen, Na; Ko, Kam Ming
Article

Supplementation with the Extract of Schisandrae Fructus Pulp, Seed, or Their Combination Influences the Metabolism of Lipids and Glucose in Mice Fed with Normal and Hypercholesterolemic Diet

Evidence-based Complementary and Alternative Medicine, v. 2014, April 2014, article number 472638
Wang, Xiao-Yan; Yu, Zhi-Ling; Pan, Si-Yuan; Zhang, Yi; Sun, Nan; Zhu, Pei-Li; Jia, Zhan-Hong; Zhou, Shu-Feng; Ko, Kam Ming
Article

Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice

Drug Design, Development and Therapy, v. 8, September 2014, p. 1429-1439
Zhang, Yi; Pan, Si-Yuan; Zhou, Shu-Feng; Wang, Xiao-Yan; Sun, Nan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Ko, Kam-Ming
Article

Ursolic Acid-Enriched Herba Cynomorii Extract Induces Mitochondrial Uncoupling and Glutathione Redox Cycling Through Mitochondrial Reactive Oxygen Species Generation: Protection Against Menadione Cytotoxicity in H9c2 Cells

Molecules, v. 19, January 2014, p. 1576-1591
Chen, Jihang; Wong, Hoi Shan; Ko, Robert Kam Ming
Article

β-Sitosterol Enhances Cellular Glutathione Redox Cycling by Reactive Oxygen Species Generated From Mitochondrial Respiration: Protection Against Oxidant Injury in H9c2 Cells and Rat Hearts

PTR. Phytotherapy research, v. 28, (7), July 2014, p. 999-1006
Wong, Hoi Shan; Chen, Na; Leong, Pou Kuan; Ko, Robert Kam Ming
Article

β-Sitosterol Protects against Carbon Tetrachloride Hepatotoxicity but not Gentamicin Nephrotoxicity in Rats via the Induction of Mitochondrial Glutathione Redox Cycling

Molecules, v. 19, (11), October 2014, p. 17649-17662
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming
Article

Pharmacological profile of dibenzocyclooctadiene lignans and other active ingredients in Schisadrae Fructus

Schisandra Chinensis: An Herb of North Eastern China Origin / By Kam-Ming Ko, Jun Yin, Chuixin Qin. Singapore : World Scientific, 2014, p. 97-138, Ch. 4
Ko, Robert Kam-Ming; Chen, Na; Leong, Pou Kuan; Ma, Chung Wah
Book chapter

Schisandrin B suppresses the lipopolysaccharide/ATP-induced Inflammasome Activation and Cytotoxicity in Isolated Mouse Peritoneal Macrophages and Cultured RAW264.7 Macrophages via Eliciting Nrf2-driven Antioxidant Response

Leong, Pou Kuan; Ko, Kam Ming
Conference paper

2013 7

A Novel Mouse Model of Combined Hyperlipidemia Associated With Steatosis and Liver Injury by a Single-Dose Intragastric Administration of Schisandrin B/Cholesterol/Bile Salts Mixture

Journal of Pharmacological Sciences, v. 123, (2), 2013, p. 110-119
Pan, Si-Yuan; Jia, Zhan-Hong; Zhang, Yi; Yu, Qing; Wang, Xiao-Yan; Sun, Nan; Zhu, Pei-Li; Yu, Zhi-Ling; Ko, Robert K.M.
Article

Caspase-3-Dependent Apoptosis of Citreamicin ε-Induced HeLa Cells Is Associated with Reactive Oxygen Species Generation

Chemical Research in Toxicology, v. 26, (7), July 2013, p. 1055-1063
Liu, Lingli; He, Lisheng; Xu, Sharon Ying; Han, Zhuang; Li, Yongxin; Zhong, Jialiang; Guo, Xianrong; Zhang, Xixiang; Ko, Robert K.M.; Qian, Peiyuan
Article

Herba Cistanches stimulates cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration in H9c2 cardiomyocytes

Pharmaceutical Biology, v. 51, (1), 2013, p. 64-73
Wong, Hoi Shan; Ko, Robert K.M.
Article

Long-Term Treatment with an Herbal Formula MCC Reduces the Weight Gain in High Fat Diet-Induced Obese Mice

Chinese Medicine, v. 4, (3), September 2013, article number 36112, p. 63-71
Leong, Pou Kuan; Leung, Hoi Yan; Wong, Hoi Shan; Chen, Jihang; Ma, Chung Wa; Yang, Yiting; Ko, Robert K.M.
Article

New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics

Evidence-based Complementary and Alternative Medicine, v. 2013, 2013, article number 627375
Pan, Si-Yuan; Zhou, Shu-Feng; Gao, Si-Hua; Yu, Zhi-Ling; Zhang, Shuo-Feng; Tang, Min-Ke; Sun, Jian-Ning; Ma, Dik-Lung; Han, Yi-Fan; Fong, Wang-Fun; Ko, Robert K.M.
Article

Schisandrin B enhances hepatic/myocardial glutathione regeneration capacity and protects against oxidant injury in rat livers and hearts

The Open Nutraceuticals Journal, v. 6, (1), 2013, p. 124-128
Leong, Pou Kuan; Chen, Na; Ko, Robert K.M.
Article

Ursolic-Acid-Enriched Herba Cynomorii Extract Protects against Oxidant Injury in H9c2 Cells and Rat Myocardium by Increasing Mitochondrial ATP Generation Capacity and Enhancing Cellular Glutathione Redox Cycling, Possibly through Mitochondrial Uncoupling

Evidence-Based Complementary and Alternative Medicine, v. 2013, March 2013, article number 924128
Chen, Jihang; Ko, Robert K.M.
Article

2012 15

"Qi-Invigorating” Chinese Tonic Herbs (Shens) Stimulate Mitochondrial ATP Generation Capacity in H9c2 Cardiomyocytes in Situ and Rat Hearts ex Vivo

Chinese Medicine, v. 3, (2), June 2012, p. 101-105
Wong, Hoi Shan; Cheung, Weng Fat; Tang, Wai Ling; Ko, Robert K.M.
Article

A Hypothetical Anti-Aging Mechanism of “Yang-Invigorating” Chinese Tonic Herbs

Chinese Medicine, v. 3, (1), March 2012, article number 18126
Lam, Yeung; Wong, Hoi Shan; Chen, Jihang; Ko, Robert K.M.
Article

Beneficial effect of (-)Schisandrin B against 3-nitropropionic acid-induced cell death in PC12 cells

BioFactors, v. 38, (3), May/June 2012, p. 219-225
Lam, Yeung; Ko, Robert K.M.
Article

Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes

Cell Biology International, v. 36, (3), March 2012, p. 321-326
Leong, Pou Kuan; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M.
Article

Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes

Indian Journal of Pharmacology, v. 44, (2), March 2012, p. 204-209
Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M.
Article

Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity

Lipids in Health and Disease, v. 11, September 2012, article number 120
Pan, Si-Yuan; Yu, Qing; Zhang, Yi; Wang, Xiao-Yan; Sun, Nan; Yu, Zhi-Ling; Ko, Robert K.M.
Article

Long-Term Treatment with a Health Product (Squina Diacylglyceryl Ether) Enhances Innate and Adaptive Immunity in Mice

Journal of Complementary and Integrative Medicine, v. 9, (1), November 2012
Leung, Hoi Yan; Ko, Robert K.M.
Article

Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases

Clinical and Experimental Pharmacology & Physiology, v. 39, (3), March 2012, p. 256-264
Leong, Pou Kuan; Chen, Na; Ko, Robert K.M.
Article

Neuroprotection against oxidative injury by a nucleic acid-based health product (Squina DNA) through enhancing mitochondrial antioxidant status and functional capacity

Journal of Medicinal Food, v. 15, (7), June 2012, p. 629-638
Lam, Yeung; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M.
Article

New Perspectives on Complementary and Alternative Medicine: An Overview and Alternative Therapy

Alternative Therapies in Health and Medicine, v. 18, (4), July 2012, p. 20-36
Pan, Si-Yuan; Gao, Si-Hua; Zhou, Shu-Feng; Tang, Min-Ke; Yu, Zhi-Ling; Ko, Robert K.M.
Article

Product Design: A Nanomized Nutraceutical with Enhanced Bioactivity and Bioavailability

Industrial & Engineering Chemistry Research, v. 51, (21), May 2012, p. 7320-7326
Lau, Yeuk Tin; Chen, Na; Ko, Robert K.M.; Ng, Ka Ming
Article

Prooxidant-Induced Glutathione Antioxidant Response in Vitro and in Vivo: A Comparative Study between Schisandrin B and Curcumin

Biological and Pharmaceutical Bulletin, v. 35, (4), April 2012, p. 464-472
Leong, Pou Kuan; Chiu, Po Yee; Ko, Robert K.M.
Article

Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases

Oxidative Medicine and Cellular Longevity, v. 2012, March 2012, article number 250825
Lam, Yeung; Ko, Robert K.M.
Article

Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice

Free Radical Research, v. 46, (1), January 2012, p. 50-60
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Bhilwade, Hari N.; Ko, Robert K.M.; Watanabe, Kenichi; Konishi, Tetsuya
Article

五味子及其成分的葯理毒理研究

东北道地药材-五味子 - Schisandra chinensis from North East China / 殷军. 中国医药科技出版社, 2012, p. 74-129
Ko, Robert Kam Ming; Chen, Na; Hua, Y.L.
Book chapter

2011 20

(-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells

BioFactors, v. 37, (1), January/February 2011, p. 51-57
Lam, Yeung; Ko, Robert K.M.
Article

‘Yang-Invigorating’ Chinese Tonic Herbs Enhance Mitochondrial ATP Generation in H9c2 Cardiomyocytes

Chinese Medicine, v. 2, March 2011
Wong, Hoi Shan; Leung, Hoi Yan; Ko, Robert K.M.
Article

A Proteomic Approach in Investigating the Hepatoprotective Mechanism of Schisandrin B: Role of Raf Kinase Inhibitor Protein

Journal of proteome research, v. 10, (1), January 2011, p. 299-304
Chen, Yan; Ip, Siu-Po; Ko, Robert K.M.; Poon, Terence C.W.; Ng, Eddy W.Y.; Lai, Paul B.S.; Mao, Qing-Qiu; Xian, Yan-Fang; Che, Chun-Tao
Article

Acute treatment with Danshen–Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCɛ/mK_ATP pathway in rats

Phytomedicine, v. 18, (11), August 2011, p. 916-925
Chiu, Po Yee; Wong, Sze Man; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M.
Article

Co-treatment with shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats

Rejuvenation Research, v. 14, (1), February 2011, p. 17-23
Chiu, Po Yee; Lam, Yeung; Leung, Hoi Yan; Leong, Pou Kuan; Ma, Chung Wah; Tang, Qing Tao; Ko, Robert K.M.
Article

Danshen–Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKCɛ/mK_ATP pathways in H9c2 cardiomyocytes

Phytomedicine, v. 19, (2), January 2012, p. 99-110
Chiu, Po Yee; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zou, Zhong; Lam, Yeung; Ko, Robert K.M.
Article

Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate

Naunyn-Schmiedeberg's Archives of Pharmacology, v. 383, (6), June 2011, p. 585-591
Pan, Si-Yuan; Dong, Hango; Guo, Bao-Feng; Zhang, Yi; Yu, Zhi-Ling; Fong, Wang-Fun; Han, Yi-Fan; Ko, Robert K.M.
Article

Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High Fat/Cholesterol Diet, with Attention to Acute Toxicity

Evidence-Based Complementary and Alternative Medicine, v. 2011, 2011
Pan, Si-Yuan; Yu, Zhi-Ling; Dong, Hang; Xiang, Chun-Jing; Fong, Wang-Fun; Ko, Robert K.M.
Article

Immunopotentiating Activity of Dendrobium Species in Mouse Splenocytes

Chinese Medicine, v. 2, (3), September 2011, p. 103-108
Lau, David T.W.; Poon, Michel K.T.; Leung, Hoi Yan; Ko, Robert K.M.
Article

Long-term treatment with danshen-gegen decoction protects the myocardium against Ischemia/reperfusion injury via the redox-sensitive protein kinase C-ε/mK_ATP pathway in rats

Rejuvenation Research, v. 14, (2), May 2011, p. 173-184
Chiu, Po Yee; Wong, Sze Man; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M.
Article

Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mK_ATP-mediated pathway in rats

Chinese Medicine, v. 6, February 2011, article number 7
Wong, Sze Man; Chiu, Po Yee; Leung, Hoi Yan; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M.
Article

New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development

Evidence-Based Complementary and Alternative Medicine, v. 2011, 2011
Pan, Si-Yuan; Chen, Si-Bao; Dong, Hong-Guang; Yu, Zhi-Ling; Dong, Ji-Cui; Long, Zhi-Xian; Fong, Wang-Fun; Han, Yifan; Ko, Robert K.M.
Article

Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice

Free Radical Research, v. 45, (8), August 2011, p. 950-958
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Sato, Shinji; Ko, Robert K.M.; Konishi, Tetsuya
Article

Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes

Free Radical Research, v. 45, (4), 2011, p. 483-495
Leong, Pou Kuan; Chiu, Po Yee; Chen, Na; Leung, Hoi Yan; Ko, Kam Ming
Article

Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells

Molecular and Cellular Biochemistry, v. 350, (1-2), April 2011, p. 237-250
Chiu, Po Yee; Chen, Na; Leong, Po Kuan; Leung, Hoi Yan; Ko, Robert K.M.
Article

Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells

BioFactors, v. 37, (6), November/December 2011, p. 439-446
Lam, Yeung; Leong, Pou Kuan; Chen, Na; Ko, Robert K.M.
Article

Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts

Fitoterapia, v. 82, (4), June 2011, p. 682-691
Chiu, Po Yee; Lam, Yeung; Yan, Chung Wai; Ko, Robert K.M.
Article

Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue

Fitoterapia, v. 82, (3), April 2011, p. 393-400
Lam, Yeung; Yan, Chung Wai; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M.
Article

Tacrine and Bis(7)-Tacrine Attenuate Cycloheximide-Induced Amnesia in Mice, with Attention to Acute Toxicity

Basic & Clinical Pharmacology & Toxicology, v. 109, (4), October 2011, p. 261-265
Pan, Si-Yuan; Zhang, Yi; Guo, Bao-feng; Han, Yi-Fan; Ko, Robert K.M.
Article

Tacrine Treatment at High Dose Suppresses the Recognition Memory in Juvenile and Adult Mice with Attention to Hepatotoxicity

Basic & Clinical Pharmacology & Toxicology, v. 108, (6), June 2011, p. 421-427
Pan, Si-Yuan; Guo, Bao-Feng; Zhang, Yi; Yu, Qing; Yu, Zhi-Ling; Dong, Hang; Ye, Yan; Han, Yi-Fan; Ko, Robert K.M.
Article

2010 10

A Red Wine Extract Supplement Protects against Apoptosis and Inhibits Changes in Mitochondrial Permeability and Membrane Potential

Journal of Complementary and Integrative Medicine, v. 7, (1), January 2010
Chen, Na; Chiu, Po Yee; Ko, Robert K.M.
Article

Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells

Journal of Ethnopharmacology, v. 128, (1), March 2010, p. 116-122
Chen, Meng-Li; Ip, Siu-Po; Tsai, Sam-Hip; Ko, Robert K.M.; Che, Chun-Tao
Article

Herba Cistanche extract enhances mitochondrial glutathione status and respiration in rat hearts, with possible induction of uncoupling proteins

Pharmaceutical Biology, v. 48, (5), April 2010, p. 512-517
Siu, A.H.L.; Ko, Robert K.M.
Article

Long-Term Dietary Supplementation with a Yang-Invigorating Chinese Herbal Formula Increases Lifespan and Mitigates Age-Associated Declines in Mitochondrial Antioxidant Status and Functional Ability of Various Tissues in Male and Female C57BL/6J Mice

Rejuvenation Research, v. 13, (2-3), May 2010, p. 168-171
Ko, Robert K.M.; Chiu, Po Yee; Leung, Hoi Yan; Siu, A.H.L.; Chen, Na; Leong, Eriol Pou Kwan; Poon, Michel K.T.
Article

Long-Term Treatment with a "Yang-Invigorating" Chinese Herbal Formula, Wu-Zi-Yan-Zong-Wan, Reduces Mortality and Liver Oxidative Damage in Chronic Alcohol-Intoxicated Rats

Rejuvenation Research, v. 13, (4), August 2010, p. 459-467
Chen, Meng-Li; Tsai, Sam-Hip; Ip, Siu-Po; Ko, Robert K.M.; Che, Chun-Tao
Article

Long-Term Treatment with Shengmai San-Derived Herbal Supplement (Wei Kang Su) Enhances Antioxidant Response in Various Tissues of Rats with Protection Against Carbon Tetrachloride Hepatotoxicity

Journal of Medicinal Food, v. 13, (2), April 2010, p. 427-438
Leong, Pou Kuan; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ma, Chung Wah; Tang, Qing Tao; Ko, Robert K.M.
Article

New perspectives on innovative drug discovery: An overview

Journal of Pharmacy and Pharmaceutical Sciences, v. 13, (3), 2010, p. 450-471
Pan, Si-Yuan; Pan, Shan; Yu, Zhi-Ling; Ma, Dik-Lung; Chen, Si-Bao; Fong, Wang-Fun; Han, Yifan; Ko, Robert K.M.
Article

Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats

Fitoterapia, v. 81, (8), December 2010, p. 1239-1245
Lam, Yeung; Chiu, Po Yee; Leung, Hoi Yan; Chen, Na; Leong, Pou Kuan; Ko, Robert K.M.
Article

Schisandrin B-Induced Glutathione Antioxidant Response and Cardioprotection are Mediated by Reactive Oxidant Species Production in Rat Hearts

Biological and Pharmaceutical Bulletin, v. 33, (5), May 2010, p. 825-829
Chen, Na; Ko, Robert K.M.
Article

Antioxidant and anticarcinogenic potential of sesame lignans

Sesame: The genus Sesamum. Medicinal and Aromatic Plants – Industrial Profiles. / Edited by Dorothea Bedigian. Boca Raton : CRC Press, Taylor & Francis Group, 2010, p. 111-131, Ch. 5
Mak, Duncan H.K.; Chiu, Po Yee; Ko, Robert Kam Ming
Book chapter

2009 10

An integrative approach to product development-A skin-care cream

Computers & chemical engineering, v, 33, (5), May 2009, p. 1097-1113
Cheng, Yuen Shan; Lam, Ka Wing; Ng, Ka Ming; Ko, Robert Kam Ming; Wibowo, Christianto
Article

Comparison Studies of Tacrine and Bis(7)-Tacrine on the Suppression of Scopolamine-Induced Behavioral Changes and Inhibition of Acetylcholinesterase in Mice

Pharmacology, v. 83, (5), 2009, article number PHA2009083005294, p. 294-300
Pan, Si-Yuan; Yu, Zhi-Ling; Xiang, Chun-Jing; Dong, Hang; Fang, Hai-Yan; Ko, Kam-Ming
Article

Effect of Extraction Solvent on the Bioactivity of an Herbal Formulation

Industrial and Engineering Chemistry Research, v. 48, (10), May 2009, p. 4852-4857
Chan, Kin N.; Lau, Choi C.; Chow, King Lau; Ko, Robert Kam Ming; Tsim, Karl Wah Keung; Ng, Ka Ming
Article

Effects of peony glycosides on mice exposed to chronic unpredictable stress: Further evidence for antidepressant-like activity

Journal of ethnopharmacology, v. 124, (2), July 2009, p. 316-320
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Xian, Yan-Fang; Che, Chun-Tao
Article

Exposure to oscillating high electrical potential and the associated low frequency magnetic field enhances the hepatoprotective action of schisandrin B in vivo and in vitro

Journal of Complementary and Integrative Medicine, v. 6, (1), 2009, article number 23
Ko, Kam Ming; Siu, Ada Hoi Ling; Poon, Michel Kong Tat; Leung, Hoi Yan; Chiu, Po Yee
Article

Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response

Nucleic acids research, v. 37, (17), September 2009, p. 5678-5689
Nishida, Hiroshi; Tatewaki, Naoto; Nakajima, Yuki; Magara, Taku; Ko, Kam Ming; Hamamori, Yasuo; Konishi, Tetsuya
Article

Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: Effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor

Progress in neuro-psychopharmacology & biological psychiatry, v. 33, (7), October 2009, p. 1211-1216
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Che, Chun-Tao
Article

Peony Glycosides Protect Against Corticosterone-Induced Neurotoxicity in PC12 Cells

Cellular and molecular neurobiology, v. 29, (5), July 2009, p. 643-647
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Zhao, Ming; Che, Chun-Tao
Article

Protective effect of red wine extract supplement against myocardial ischemia/reperfusion injury in rats: Effects on mitochondrial antioxidant and structural parameters

Journal of Complementary and Integrative Medicine, v. 6, (1), 2009, article number 21
Ko, Kam Ming; Chen, Na; Chiu, Po Yee
Article

Schisandrin B Stereoisomers Protect against Hypoxia/Reoxygenation-induced Apoptosis and Associated Changes in the Ca-2+-induced Mitochondrial Permeability Transition and Mitochondrial Membrane Potential in AML12 Hepatocytes

Phytotherapy research, v. 23, (11), November 2009, p. 1592-1602
Chiu, Po Yee; Luk, Ka Fai; Leung, Hoi Yan; Ng, Ka Ming; Ko, Robert Kam Ming
Article

2008 13

A `Yang-invigorating' Chinese herbal formula protects against gentamicin-induced nephrotoxicity in rats

Phytotherapy research, v. 22, (1), January 2008, p. 131-133
Poon, Michel Kwong Tat; Chiu, Po Yee; Leung, Hoi Yan; Sin, Ada Hoi Ling; Ko, Kam Ming
Article

Herba Cistanche extract enhances mitochondrial ATP generation in rat hearts and H9C2 cells

Pharmaceutical biology, v. 46, (6), October 2008, p. 428-424
Leung, Hoi Yan; Ko, Kam Ming
Article

Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice

BioFactors, v. 34, (4), December 2008, p. 331-342
Ko, Kam Ming; Chen, Na; Leung, Hoi Yan; Leong, Eriol P.K.; Poon, Michel K.T.; Chiu, Po Yee
Article

Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis

Rejuvenation Research, v. 11, (6), December 2008, p. 991-1000
Zhang, Guang-Qin; Wang, Hui; Liu, Wen-Tao; Dong, Hang; Fong, Wang-Fun; Tang, Li-Min; Xiong, Yun-Hua; Yu, Zhi-Ling; Ko, Kam-Ming
Article

Long-term treatment with a yang-invigorating chinese herbal formula produces generalized tissue protection against oxidative damage in rats

Rejuvenation research, v. 11, (1), February 2008, p. 43-62
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Chen, Na; Poon, Michel K.T.; Ko, Kam Ming
Article

Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats

Biological and Pharmaceutical Bulletin, v. 31, (7), July 2008, p. 1387-1391
Chen, Na; Chiu, Po Yee; Ko, Kam Ming
Article

Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats

Biological & pharmaceutical bulletin, v. 31, (4), April 2008, p. 602-605
Chiu, Po Yee; Leung, Hoi Yan; Ko, Kam Ming
Article

Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice

Journal of Pharmacy and Pharmacology, v. 60, (3), March 2008, p. 399-403
Pan, Si-Yuan; Dong, Hang; Zhao, Xing-Ye; Xiang, Chun-Jing; Fang, Hai-Yan; Fong, Wang-Fun; Yu, Zhi-Ling; Ko, Kam-Ming
Article

Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes

Life Sciences, v. 82, (21-22), May 2008, p. 1092-1101
Chiu, Po Yee; Luk, Ka Fai; Leung, Hoi Yan; Ng, Ka Ming; Ko, Kam Ming
Article

Separation and purification of (-)schisandrin B from schisandrin B stereoisomers

Biochemical Engineering Journal, v. 42, (1), October 2008, p. 55-60
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming
Article

Separation and purification of schisandrin B from Fructus schisandrae

Industrial and Engineering Chemistry Research, v. 47, (12), June 2008, p. 4193-4201
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming
Article

Development of a skin-care cream containing zinc oxide nanoparticles and an herbal extract

2008 AIChE Annual Meeting, AIChE 100, Philadelphia, PA, United States, 16-21 November 2008
Cheng, Yuen Shan; Lam, Ka Wing; Ng, Ka Ming; Ko, Robert Kam Ming; Wibowo, Christianto
Conference paper

Separation and purification of (-)schisandrin B from schisandrin B stereoisomers

AIChE Annual Meeting, Conference Proceedings, AIChE 100, Philadelphia, PA, United States, 16-21 November 2008, 2008
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming
Conference paper

2007 6

Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice

Journal of Pharmacy and Pharmacology, v. 59, (12), 2007, DEC, p. 1657-1662
Pan, Si-Yuan; Dong, Hang; Yu, Zhi-Ling; Zhao, Xin-Ye; Xiang, Chun-Jing; Wang, Hui; Fong, Wang-Fun; Ko, Kam-Ming
Article

Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: Role of glutathione synthesis and regeneration

Planta medica, v. 73, (2), 2007, FEB, p. 134-141
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada H.Y.; Poon, Michel K.T.; Dong, Tina Tingxia; Tsim, Karl Wah Keung; Ko, Kam Ming
Article

Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs

Chinese Medicine, v. 2, 2007
Ko, Kam Ming; Leung, Hoi Yan
Article

Evaluation of acute bis(7)-tacrine treatment on behavioral functions in 17-day-old and 30-day-old mice, with attention to drug toxicity

Pharmacology BIOCHEMISTRY and Behavior, v. 86, (4), 2007, APR, p. 778-783
Pan, Si Yuan; Yu, Zhi Ling; Dong, Hang; Lee, Nelson Tsz Kin; Wang, Hui; Fong, Wang Fun; Han, Yi Fan; Ko, Kam Ming
Article

Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers

Biological & pharmaceutical bulletin, v. 30, (6), 2007, JUN, p. 1108-1112
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Poon, Michel Kong Tat; Ko, Kam Ming
Article

Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts

ACTA PHARMACOLOGICA SINICA, v. 28, (10), 2007, OCT, p. 1559-1565
Chiu, Po-Yee; Leung, Hoi-Yan; Siu, Ada Hoi Ling; Poon, Michel Kwong Tat; Ko, Kam-Ming
Article

2006 14

(-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes

Molecular and cellular biochemistry, v. 289, (1-2), 2006, SEP, p. 185-191
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Mak, Duncan H.F.; Ko, Kam Ming
Article

A characteristic pharmacological action of `Yang-invigorating' Chinese tonifying herbs: Enhancement of myocardial ATP-generation capacity

Phytomedicine, v. 13, (9-10), 2006, NOV, p. 636-642
Ko, Kam-Ming; Leon, T.Y.Y.; Mak, Duncan H.F.; Chiu, Po-Yee; Du, Ying; Poon, Michel Kwong Tat
Article

A novel experimental model of acute hypertriglyceridemia induced by schisandrin B

European journal of pharmacology, v. 537, (1-3), 2006, MAY 10, p. 200-204
Pan, Si Yuan; Dong, Hang; Han, Yi Fan; Li, Wen Yuan; Zhao, Xing Y.; Ko, Kam Ming
Article

Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice

European journal of pharmacology, v. 552, (1-3), 2006, DEC 15, p. 170-175
Pan, Si-Yuan; Yang, Rong; Dong, Hang; Yu, Zhi-ling; Ko, Kam-Ming
Article

Biochemical basis of the "Qi-invigorating" action of Schisandra berry (Wu-Wei-Zi) in Chinese medicine

AMERICAN JOURNAL OF CHINESE MEDICINE, v. 34, (2), 2006, p. 171-176
Ko, Kam Ming; Chiu, Po Yee
Article

Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats

Biogerontology, v. 7, (4), 2006, AUG, p. 199-210
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Ko, Kam Ming
Article

Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes

Phytotherapy research, v. 20, (7), 2006, JUL, p. 561-567
Mak, Duncan Hon Fai; Chiu, Po Yee; Dong, Tina Ting Xia; Tsim, Karl Wah Keung; Ko, Kam Ming
Article

Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts

Molecular and cellular biochemistry, v. 288, (1-2), 2006, AUG, p. 135-142
Du, Ying; Ko, Kam Ming
Article

Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes

Pharmacology, v. 77, (2), 2006, p. 63-70
Chiu, PY; Leung, HY; Poon, MKT; Mak, DHF; Ko, KM
Article

Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17-and 30-day-old mice

Pharmacology BIOCHEMISTRY and Behavior, v. 85, (1), 2006, SEP, p. 50-56
Pan, Si Yuan; Han, Yi Fan; Yu, Zhi Ling; Yang, Rong; Dong, Hang; Ko, Kam Ming
Article

High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia

ACTA PHARMACOLOGICA SINICA, v. 27, (6), 2006, JUN, p. 673-678
Pan, Si Yuan; Yang, Rong; Han, Yi Fan; Dong, Hang; Feng, Xu Dong; Li, Na; Geng, Wei; Ko, Kam Ming
Article

Oleanolic acid protects against myocardial ischemia-reperfusion injury by enhancing mitochondrial antioxidant mechanism mediated by glutathione and alpha-tocopherol in rats

Planta medica, v. 72, (3), 2006, FEB, p. 222-227
Du, Ying; Ko, Kam Ming
Article

Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver

Molecular and cellular biochemistry, v. 293, (1-2), 2006, DEC, p. 87-92
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Lee, Susanna S.T.; Ko, Kam Ming
Article

Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells

BioFactors, v. 26, (4), 2006, p. 221-230
Chiu, Po Yee; Ko, Kam Ming
Article

2005 4

A Yang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats

Rejuvenation research, v. 8, (4), 2005, WIN, p. 238-247
Leung, Hoi Yan; Chiu, Po Yee; Poon, Michel Kwong Tat; Ko, Kam Ming
Article

Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: Single versus multiple doses and gender difference

Life sciences, v. 77, (22), 2005, OCT 14, p. 2770-2782
Du, Ying; Ko, Kam Ming
Article

Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver

Life sciences, v. 77, (23), 2005, OCT 21, p. 2887-2895
Chiu, PY; Mak, DHF; Poon, MKT; Ko, KM
Article

A "Yang-invigorating" Chinese herbal suppository preparation relieves symptoms in patients with Parkinson's disease

New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005, 2005, p. 243-246
Ko, KM; Chan, K.; Shek, L.; Yeung, J.; Chui, SH
Conference paper

2004 7

A Yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects

Phytotherapy research, v. 18, (7), 2004, JUL, p. 525-530
Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat; Ng, Timothy TL; Chung, YK; Lam, BYH; Du, Ying; Ko, KM
Article

Comparing an in vitro electrochemical measurement of superoxide scavenging activity with an in vivo assessment of antioxidant potential in Chinese tonifying herbs

Phytotherapy research, v. 18, (2), 2004, FEB, p. 149-153
Beissenhirtz, Moritz K.; Kwan, Roger Cheuk Hung; Ko, Kam Ming; Renneberg, Reinhard; Scheller, Frieder W.; Lisdat, Fred
Article

Pharmacological basis of `Yang-invigoration' in Chinese medicine

Trends in pharmacological sciences, v. 25, (1), 2004, JAN, p. 3-6
Ko, Kam Ming; Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat
Article

Pharmacological basis of `Yin-nourishing' and `Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb

Life sciences, v. 76, (4), 2004, DEC 10, p. 385-395
Siu, Kai Ming; Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat; Du, Ying; Ko, KM
Article

Processing control of Chinese herbal products: An ultimate approach for quality assurance

Asia-Pacific Biotech News, v. 8, (23), 2004, p. 1338-1341
Ko, Robert Kam Ming; Ng, Ka Ming
Article

Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats

Molecular and cellular biochemistry, v. 266, (1-2), 2004, NOV, p. 139-144
Chiu, Po Yee; Ko, Kam Ming
Article

Deciphering the Myth of Fructus Schisandrae in Traditional Chinese Medicine: Biochemical Basis of its Qi-invigorating Action

Recent Progress in Medicinal Plants Volume 9: Plant Bioactives in Traditional Medicine / J.N. Govil, V.K. Singh, Rajeev Kr. Sharma. Studium Press LLC, 2005, p. 147-163
Ko, K.M.; Chiu, P.Y.
Book chapter

2003 10

Challenges in the globalization of Chinese herbal medicine

Asia-Pacific Biotech News., 7:1287-89
Ko, K.M.
Article

East meets west in anti-aging medicine

Annal Asia Anti-aging Med. Assoc., 2004:39-44
Ko, K.M.
Article

Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice

BioFactors, v. 19, (1-2), 2003, p. 33-42
Tang, Man Ho; Chiu, Po Yee; Ko, Kam Ming
Article

Hepatoprotective mechanism of schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins

FREE RADICAL BIOLOGY AND MEDICINE, v. 35, (4), 2003, AUG 15, p. 368-380
Chiu, Po Yee; Tang, Man Ho; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Ko, Kam Ming
Article

Metformin protects against carbon tetrachlordie hepatootoxicity in mice: Enhancement of mitochondrial glutathione redox status

Journal of pharmacological sciences, v. 93, (4), 2003, DEC, p. 501-504
Poon, Michel Kwong Tat; Chiu, Po Yee; Mak, Duncan Hon Fai; Ko, Kam Ming
Article

Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury

BioFactors, v. 19, (1-2), 2003, p. 43-51
Chiu, Po Yee; Ko, Kam Ming
Article

Schisandrin B and other Dibenzocyclooctadiene lignans. In: Herbal Medicines: Molecular Basis in Health & Diseases Management

Ko, K.M.
Book

Anti-aging effects of a Chinese medicine preparation on elderly male subjects

2nd Asia Pacific Conferenece and Exhibition on Anti-Aging Medicine, Singapore, p.73, September
Ko, K.M.
Conference paper

Antioxidant potential of a Chinese Medicine Preparation in vitro and in vivo/ex vivo

2nd Asia Pacific Conference and Exhibition on Anti-Aging Medicine 2003, Singapore, p.50, September
Ko, K.M.; Mak, Duncan H.F.; Poon, Michel K.T.
Conference paper

Biochemical, immunological, hormonal and anti-oxidant effects of a Chinese Herbal Suppository, Vigconic HY28, on Elderly Male Subjects - An anti-aging solution?

Anti-Aging World Conference, Paris, France, p.105
Chui, Siu Hon; Ko, Kam Ming
Conference paper

2002 10

Antioxidant and immunomodulatory activities of Chinese tonifying herbs

Pharmaceutical biology, v. 40, (5), 2002, AUG, p. 329-335
Yim, Tze Kin; Ko, Kam Ming
Article

In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin

Planta medica, v. 68, (11), 2002, NOV, p. 951-956
Chiu, Po Yee; Mak, Duncan Hon Fai; Poon, Michel Kong Tat; Ko, Kam Ming
Article

Protection against carbon tetrachloride liver toxicity by enantiomers of schisandrin B associated with differential changes in hepatic glutathione antioxidant system in mice

Pharmaceutical biology, v. 40, (4), 2002, p. 298-301
Ko, Kam Ming; Poon, Michel Kwong Tat; Ip, Siu Po; Wu, Kim
Article

Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice

Planta medica, v. 68, (3), 2002, MAR, p. 217-220
Pan, Si Yuan; Han, Yi Fan; Carlier, Paul R.; Pang, Yuan Ping; Mak, Duncan Hon Fai; Lam, Brian Yee Hong; Ko, Kam Ming
Article

Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain

Molecular and cellular biochemistry, v. 238, (1-2), 2002, SEP, p. 181-186
Ko, Kam Ming; Lam, Brian Yee Hong
Article

Shengmai San

Ko, Kam Ming
Book

Pharmacological studies on Shengmai San

Shengmai San / Editied by Kam-Ming Ko. London: Taylor & Francis, 2002, p. 16-40
Ko, Kam Ming; Mak, Duncan Hon Fai; Yim, Tsz Kin; Yan, Yong Qing
Book chapter

A question of quality

Current Drug Discovery, (MAY), 2002, p. 41-42
Ko, Robert Kam Ming
Conference paper

Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione antioxidant status and induction of heat shock proteins in mice.

2nd International Symposium on Antioxidants in Nutrition & Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Society for Free Radical Research, Bali, Indonesia, October 2-4, p.77
Tang, Man Ho; Chiu, Po Yee; Ko, Kam Ming
Conference paper

Time-dependent enhancement in mitochondrial glutathione antioxidant and functional status by schisandrin B treatment decrease the susceptibility of rats hearts to ischemia-reperfusion injury.

2nd International Symposium on Antioxidants in Nutrition & Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Society for Free Radical Research, Bali, Indonesia, October 2-4, p. 75
Chiu, Po Yee; Ko, Kam Ming
Conference paper

2001 5

Altered susceptibility to ischemia-reperfusion injury in isolated-perfused hearts of short-term diabetic rats associated with changes in non-enzymatic antioxidants

Japanese journal of pharmacology, v. 85, (4), 2001, APR, p. 435-442
Ko, Kam Ming; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Yiu, Ho Yan
Article

Effects of Fructus Ligustri Lucidi extracts on concanavalin A-stimulated proliferation of isolated murine splenocytes

Pharmaceutical biology, v. 39, (2), 2001, p. 146-151
Yim, Tze Kin; Ko, Kam Ming
Article

Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver

Cell stress & chaperones, v. 6, (1), 2001, JAN, p. 44-48
Ip, Siu Po; Che, Chun Tao; Kong, Yun Cheung; Ko, Kam Ming
Article

Hepatoprotective action of an oleanolic acid-enriched extract of Ligustrum lucidum fruits is mediated through an enhancement on hepatic glutathione regeneration capacity in mice

Phytotherapy research, v. 15, (7), 2001, NOV, p. 589-592
Yim, Tze Kin; Wu, WK; Pak, WF; Ko, Kam Ming
Article

Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts

Molecular and cellular biochemistry, v. 220, (1-2), 2001, APR, p. 141-147
Ko, Kam Ming; Yiu, Ho Yan
Article

2000 3

Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice

Molecular and cellular biochemistry, v. 205, (1-2), 2000, FEB, p. 111-114
Ip, Siu Po; Yiu, Ho Yan; Ko, Kam Ming
Article

Myocardial protection against ischaemia-reperfusion injury by a Polygonum multiflorum extract supplemented `Dang-Gui Decoction for Enriching Blood', a compound formulation, ex vivo

Phytotherapy research, v. 14, (3), 2000, MAY, p. 195-199
Yim, Tze Kin; Wu, WK; Pak, WF; Mak, Duncan Hon Fai; Liang, SM; Ko, Kam Ming
Article

Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity

Molecular and cellular biochemistry, v. 208, (1-2), 2000, MAY, p. 151-155
Ip, Siu Po; Yiu, Ho Yan; Ko, Kam Ming
Article

1999 2

Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats

Biochemical pharmacology, v. 57, (1), 1999, JAN 1, p. 77-81
Yim, Tze Kin; Ko, Kam Ming
Article

Schisandrin B protects against myocardial ischemia-reperfusion injury by enhancing myocardial glutathione antioxidant status

Molecular and cellular biochemistry, v. 196, (1-2), 1999, JUN, p. 151-156
Yim, Tze Kin; Ko, Kam Ming
Article

1998 3

In vivo antioxidant mechanism of `Sheng Mai San', a compound formulation

Pharmaceutical biology, v. 36, (3), 1998, JUL, p. 189-193
Yick, Pak Kin; Poon, Michel Kwong Tat; Ip, Siu Po; Ko, Kam Ming
Article

Myocardial protective effect of an anthraquinone-containing extract of Polygonum multiflorum ex vivo

Planta medica, v. 64, (7), 1998, OCT, p. 607-611
Yim, Tze Kin; Wu, WK; Mak, Duncan Hon Fai; Ko, Kam Ming
Article

Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice

ACTA PHARMACOLOGICA SINICA, v. 19, (4), 1998, JUL, p. 313-316
Ip, Siu Po; Che, Chun Tao; Ko, Kam Ming
Article

1997 4

Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: Effects of insulin and Schisandrin B treatment

Molecular and cellular biochemistry, v. 175, (1-2), 1997, OCT, p. 225-232
Mak, Duncan Hon Fai; Ko, Kam Ming
Article

Antioxidant activities of Polygonum multiflorum Thunb, in vivo and in vitro

Phytotherapy research, v. 11, (1), 1997, FEB, p. 42-44
Ip, Siu Po; Tse, ASM; Poon, Michel Kwong Tat; Ko, Kam Ming; Ma, CY
Article

Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice

Biochemical pharmacology, v. 54, (2), 1997, JUL 15, p. 317-319
Ip, Siu Po; Ma, Cui Ying; Che, Chun Tao; Ko, Kam Ming
Article

Protective effect of a lignan-enriched extract of fructus schisandrae on physical exercise induced muscle damage in rats

Phytotherapy Research, v. 11, (8), 1997, p. 450-452
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po
Article

1996 8

Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats

Molecular and cellular biochemistry, v. 162, (2), 1996, SEP 20, p. 153-158
Mak, Duncan Hon Fai; Ip, Siu Po; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming
Article

Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats

Pharmacology & toxicology, v. 78, (6), 1996, JUN, p. 413-416
Ip, Siu Po; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming
Article

Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo

Molecular and cellular biochemistry, v. 165, (2), 1996, DEC 20, p. 161-165
Mak, Duncan Hon Fai; Ip, Siu Po; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming
Article

Myocardial protective effect of Sheng Mai San (SMS) and a lignan-enriched extract of Fructus Schisandrae, in vivo and ex vivo

Phytomedicine, v. 3, (2), 1996, SEP, p. 217-221
Li, Pui Chun; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Ip, Siu Po; Ko, Kam Ming
Article

Protective effect of a lignan-enriched extract of Fructus schisandrae on physical exercise induced muscle damage in rats

Phytotherapy research, v. 10, (5), 1996, AUG, p. 450-452
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po
Article

Schisandra chinensis-dependent myocardial protective action of Sheng-Mai-San in rats

AMERICAN JOURNAL OF CHINESE MEDICINE, v. 24, (3-4), 1996, p. 255-262
Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming
Article

Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver

FREE RADICAL BIOLOGY AND MEDICINE, v. 21, (5), 1996, p. 709-712
Ip, Siu Po; Poon, Michel Kwong Tat; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung; Ko, Kam Ming
Article

The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: A comparative study with butylated hydroxytoluene

Biochemical pharmacology, v. 52, (11), 1996, DEC 13, p. 1687-1693
Ip, Siu Po; Ko, Kam Ming
Article

1995 4

Effect of a lignan-enriched fructus Schisandrae extract on hepatic glutathione status in rats: Protection against carbon tetrachloride toxicity

Planta medica, v. 61, (2), 1995, APR, p. 134-137
Ko, Kam Ming; Ip, Siu Po; Poon, Michel Kwong Tat; Wu, S.S.; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung
Article

Effect of Schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity

Planta medica, v. 61, (5), 1995, OCT, p. 398-401
Ip, Siu Po; Poon, Michel Kwong Tat; Wu, S.S.; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung; Ko, Kam Ming
Article

Enhancement of hepatic glutathione regeneration capacity by a lignan-enriched extract of fructus schisandrae in rats

Japanese journal of pharmacology, v. 69, (4), 1995, DEC, p. 439-442
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po
Article

Schisandra Chinensis-derived antioxidant activities in 'Sheng Mai San', a compound formulation, in vivo and in vitro

Phytotherapy research, v. 9, (3), 1995, MAY, p. 203-206
Ko, Kam Ming; Yick, Pak Kin; Poon, Michel Kwong Tat; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung
Article

1994 1

Prooxidant and antioxidant effects of trolox on ferric ion-induced oxidation of erythrocyte membrane lipids

Molecular and Cellular Biochemistry, v. 141, (1), p. 65-70
Ko, Kam Ming; Yick, Pak Kin; Poon, Michael K.T.; Ip, Siu Po
Article

1993 1

Impaired hepatic antioxidant status in carbon tetrachloride intoxicated rats: An in vivo model for screening herbal extracts with antioxidant activities

Fitoterapia, v. 64, (6), 1993, p. 539-544
Ko, Kam Ming; Yick, Pak Kin; Chiu, Tillie; Hui, T.Y.; Cheng, Christopher Hon Ki; Kong, Yun Cheung
Article

1990 1

Inhibition of transition metal ion-catalysed ascorbate oxidation and lipid peroxidation by allopurinol and oxypurinol

Biochemical Pharmacology, v. 40, Issue 4, 15 August 1990, Pages 803-809
Ko, Kam Ming; Godin, David V.
Article

BTEC5550	Nutraceuticals and Transgenic Products
LIFS1010	Introduction to Biological Sciences
LIFS2720	Biochemistry Laboratory
LIFS4760	Biochemistry of Diseases

BIBU4840	Biotechnology and Business Capstone Project
LIFS2220	Biochemistry II
LIFS4960	Biological Science Capstone Project
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4981	Biochemistry and Cell Biology Project Research II

BIBU4840	Biotechnology and Business Capstone Project
LIFS1010	Introduction to Biological Sciences
LIFS4760	Biochemistry of Diseases
LIFS4960	Biological Science Capstone Project
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4971	Biochemistry and Cell Biology Project Research I

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