Faculty Profiles - LAKERVELD Richard | The Hong Kong University of Science and Technology

Richard LAKERVELD

PhD in Chemical Engineering
Delft University of Technology, 2010

Associate Head and Associate Professor
Department of Chemical and Biological Engineering

(852) 3469 2217
kelakerveld@ust.hk
Room CYT2003
Personal Web

Google Scholar

w6b8BHwAAAAJ

ORCID

0000-0001-7444-2678

ResearcherID

O-8763-2014

Scopus ID

55927970800

Research Interest Publications Projects Teaching Assignment RPG Supervision Space used

Research Interest

Process system engineering
Pharmaceutical manufacturing
Crystallization
Chemical process design and optimization
Process control

Publications

All Years 110 2024 1 2023 5 2022 9 2021 10 2020 9 2019 13 2018 63

2024 1

Data-driven identification of crystallization kinetics

Aiche Journal, v. 70, (5), May 2024, article number e18333
Nyande, Baggie Waponde; Nagy, Zoltan K.; Lakerveld, Richard
Article

2023 5

A Workflow for Crystallization Process Design with Simultaneous Process Optimization and Solvent Selection based on the Perturbed-Chain Statistical Associating Fluid Theory

Chemie Ingenieur Technik, v. 95, (3), March 2023, p. 334-343
Mendis, Nethrue Pramuditha; Wang, Jiayuan; Lakerveld, Richard
Article

An In Vitro Model for Cocrystal Dissolution with Simultaneous Surface and Bulk Precipitation

Molecular Pharmaceutics, v. 20, (11), November 2023, p. 5486-5499
Mendis, Nethrue Pramuditha; Lakerveld, Richard
Article

Induced-charge electroosmosis for rapid mixing of reactive precipitation systems to obtain small and uniform particles

Chemical Engineering Research and Design, v. 190, February 2023, p. 715-729
Gupta, Dishika; Nyande, Baggie Waponde; Mathew Thomas, Kiran; Li, Fei; Mak, Andrew T.C.; Lakerveld, Richard
Article

Integrated Selection of Coformers, Solvents, and Operating Conditions for Optimal Process and Product Performance of Pharmaceutical Cocrystals

Industrial & Engineering Chemistry Research, v. 62, (33), 14 August 2023, p. 13081-13095
Mendis, Nethrue Pramuditha; Li, Jiatao; Lakerveld, Richard
Article

Solvent selection for chemical reactions toward optimal thermodynamic and kinetic performances: Group contribution and COSMO-based modeling

Fluid Phase Equilibria, v. 564, January 2023, article number 113623
Wang, Jiayuan; Song, Zhen; Lakerveld, Richard; Zhou, Teng
Article

2022 9

Control of crystal size distribution in batch protein crystallization by integrating a gapped Kenics static mixer to flexibly produce seed crystals

Chemical Engineering Science, v. 263, December 2022, article number 118085
Nyande, Baggie Waponde; Mathew Thomas, Kiran; Takarianto, Abraham Aditya; Lakerveld, Richard
Article

Design and Characterization of Kenics Static Mixer Crystallizers

Chemical Engineering Research and Design, v. 179, March 2022, p. 549-563
Mathew Thomas, Kiran; Nyande, Baggie Waponde; Lakerveld, Richard
Article

Directed assembly of genetically engineered eukaryotic cells into living functional materials via ultrahigh-affinity protein interactions

Science Advances, v. 8, (44), 4 November 2022, article number eade0073
Yi, Qikun; Dai, Xin; Park, Byung Min; Gu, Junhao; Luo, Jiren; Wang, Ri; Yu, Cong; Kou, Songzi; Huang, Jinqing; Lakerveld, Richard; Sun, Fei
Article

Impact of Cooling Profile on Batch Emulsion Solution Crystallization

Industrial and Engineering Chemistry Research, v. 61, (30), August 2022, p. 11108-11115
Kwon, Soo Jin; Lakerveld, Richard
Article

Integrated membrane emulsification and solution cooling crystallization to obtain a narrow and predictable crystal size distribution

Chemical Engineering and Processing: Process Intensification, v. 171, January 2022, article number 108751
Kwon, Soo Jin; Mathew Thomas, Kiran; Lakerveld, Richard
Article

Rational Development of a Carrier-Free Dry Powder Inhalation Formulation for Respiratory Viral Infections via Quality by Design: A Drug-Drug Cocrystal of Favipiravir and Theophylline

Pharmaceutics, v. 14, (2), February 2022, article number 300
Wong, Si Nga; Weng, Jingwen; Ip, Ignatius; Chen, Ruipeng; Lakerveld, Richard; Telford, Richard; Blagden, Nicholas; Scowen, Ian J.; Chow, Shing Fung
Article

Simultaneous Solvent Selection and Process Design for Continuous Reaction–Extraction–Crystallization Systems

Industrial & Engineering Chemistry Research, v.61, (31), August 2022, p. 11504-11517
Mendis, Nethrue Pramuditha; Wang, Jiayuan; Lakerveld, Richard
Article

Staged Assembly of Colloids Using DNA and Acoustofluidics

Nano Letters, v. 22, (17), 14 September 2022, p. 6907-6915
Gao, Yu; Liu, Kun; Lakerveld, Richard; Ding, Xiaoyun
Article

A Thermodynamic Approach for Simultaneous Solvent, Coformer, and Process Optimization of Continuous Cocrystallization Processes

Proceedings of the 14th International Symposium on Process Systems Engineering – PSE 2021+, v. 49, June 2022, p. 2179-2184
Mendis, Nethrue Pramuditha; Lakerveld, Richard
Conference paper

2021 10

CFD Analysis of a Kenics Static Mixer with a Low Pressure Drop under Laminar Flow Conditions

Industrial & Engineering Chemistry Research, v. 60, (14), April 2021, p. 5264-5277
Nyande, Baggie Waponde; Mathew Thomas, Kiran; Lakerveld, Richard
Article

Characterization of Single-Cell Osmotic Swelling Dynamics for New Physical Biomarkers

Analytical Chemistry, v. 93, (3), 26 January 2021, p. 1317-1325
Fajrial, Apresio K.; Liu, Kun; Gao, Yu; Gu, Junhao; Lakerveld, Richard; Ding, Xiaoyun
Article

Continuous Protein Crystallization in Mixed-Suspension Mixed-Product-Removal Crystallizers

Crystal Growth and Design, v. 21, (2), 3 February 2021, p. 757-769
Mathew Thomas, Kiran; Kwon, Soo Jin; Lakerveld, Richard
Article

DNA dynamics and computation based on toehold-free strand displacement

Nature Communications, v. 12, (1), August 2021, article number 4994
Kang, Hong; Lin, Tong; Xu, Xiaojin; Jia, Qing-Shan; Lakerveld, Richard; Wei, Bryan
Article

Impact of cocrystal solution-state stability on cocrystal dissociation and polymorphic drug recrystallization during dissolution

International Journal of Pharmaceutics, v. 610, December 2021, article number 121239
Xuan, Bianfei; Chen, Yu Chee Sonia; Wong, Kong Ching; Chen, Ruipeng; Lo, Po Sang; Lakerveld, Richard; Tong, Henry Hoi Yee; Chow, Shing Fung
Article

Integrated Continuous Crystallization and Spray Drying of Insulin for Pulmonary Drug Delivery

Crystal Growth & Design, v. 21, (1), January 2021, p. 501-511
Chen, Ruipeng; Weng, Jingwen; Chow, Shing Fung; Lakerveld, Richard
Article

Process modeling and optimization of continuous chiral resolution by integration of membrane and crystallization technologies

Journal of Membrane Science, v. 632, August 2021, article number 119359
Capdevila-Echeverria, Jose; Wang, Jiayuan; Lakerveld, Richard; Ter Horst, Joop H.
Article

A 3D-Printed Low Pressure-Drop Plug-Flow Crystallizer for Protein Crystallization

Nyande, Baggie Waponde; Mathew Thomas, Kiran; Lakerveld, Richard
Conference paper

The Development of a Crystallization-Based Process for the Enantiomeric Enrichment of an Active Ingredient Derived from Traditional Chinese Medicine

Lo, Po Sang; Lakerveld, Richard
Conference paper

The integration of membrane emulsification and cooling crystallization of glycine

Kwon, Soo Jin; Mathew Thomas, Kiran; Lakerveld, Richard
Conference paper

2020 9

A hybrid framework for simultaneous process and solvent optimization of continuous anti-solvent crystallization with distillation for solvent recycling

Processes, v. 8, (1), January 2020, article number 63
Wang, Jiayuan; Zhu, Lingyu; Lakerveld, Richard
Article

An Ion-Specific Electrolyte Non-Random Two-Liquid Segment Activity Coefficient Model with Improved Predictive Capabilities for Aqueous Electrolyte Solutions

Fluid Phase Equilibria, v. 517, August 2020, article number 112605
Wang, Jiayuan; Li, Jintao; Cao, Wenqi; Zhu, Lingyu; Lakerveld, Richard
Article

Emulsion-assisted cooling crystallization of ibuprofen

Chemical Engineering Science, v. 226, 23 November 2020, article number 115861
Wang, Jiayuan; Cao, Wenqi; Zhu, Lingyu; Wang, Jianli; Lakerveld, Richard
Article

Open-loop control of directed self-assembly of colloidal particles in a microfluidic device

Computers & Chemical Engineering, v. 139, 4 August 2020, article number 106837
Gao, Yu; Nyande, Baggie Waponde; Lakerveld, Richard
Article

Process Control

The Handbook of Continuous Crystallization / Edited by Nima Yazdanpanah, Zoltan K Nagy. London : Royal Society of Chemistry, 2020, p. 172-218, Ch. 4
Lakerveld, Richard; Benyahia, Brahim
Book chapter

Process Intensification in Continuous Crystallization

The Handbook of Continuous Crystallization / Edited by Nima Yazdanpanah, Zoltan K Nagy. London : Royal Society of Chemistry, 2020, p. 266-320, Ch. 7
Stelzer, T.; Lakerveld, Richard; Myerson, A.S.
Book chapter

A Thermodynamic Approach for Simultaneous Solvent and Process Design of Continuous Reactive Crystallization with Recycling

Computer Aided Chemical Engineering, v. 48, 2020, p. 805-810
Mendis, Nethrue Pramuditha; Wang, Jiayuan; Lakerveld, Richard
Conference paper

Integrated Continuous Crystallization and Spray Drying of Insulin

AIChE Annual Meeting, Conference Proceedings, v. 2020-November, 2020
Chen, Ruipeng; Weng, Jingwen; Chow, Shing Fung; Lakerveld, Richard
Conference paper

Simultaneous Solvent and Process Optimization of Continuous Reactive Crystallization Processes Involving Electrolytes and Recycling Using the Electrolyte PC-SAFT

2020 Virtual AIChE Annual Meeting proceedings, v. 2020-November, November 2020
Mendis, Nethrue Pramuditha; Wang, Jiayuan; Lakerveld, Richard
Conference paper

2019 13

An Airlift Crystallizer for Protein Crystallization

Industrial & Engineering Chemistry Research, v. 58, (44), November 2019, p. 20381-20391
Mathew Thomas, Kiran; Lakerveld, Richard
Article

Cocrystal Engineering of Itraconazole with Suberic Acid via Rotary Evaporation and Spray Drying

Crystal Growth and Design, v. 19, (5), May 2019, p. 2736-2745
Weng, Jingwen; Wong, Singa; Xu, Xiaoyan; Xuan, Bianfei; Wang, Chenguang; Chen, Ruipeng; Sun, Changquan Calvin; Lakerveld, Richard; Kwok, Philip Chi Lip; Chow, Shing Fung
Article

Feedback Control for Shaping Density Distributions of Colloidal Particles in Microfluidic Devices

Lab on a Chip, v. 19, (13), July 2019, p. 2168-2177
Gao, Yu; Lakerveld, Richard
Article

Gain scheduling PID control for directed self‐assembly of colloidal particles in microfluidic devices

AIChE Journal, v. 65, (6), June 2019, article number e16582
Gao, Yu; Lakerveld, Richard
Article

Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation

Industrial and Engineering Chemistry Research, v. 58, (36), August 2019, p. 16843-16857
Hadiwinoto, Gabriela Daisy; Kwok, Philip Chi Lip; Tong, Henry H.Y.; Wong, Singa; Chow, Shingfung; Lakerveld, Richard
Article

The application of automated feedback and feedforward control to a LED-based photocatalytic reactor

Chemical Engineering Journal, v. 362, April 2019, p. 375-382
Khodadadian, Fatemeh; De La Garza, Francisco Galnares; Van Ommen, J. Ruud; Stankiewicz, Andrzej I.; Lakerveld, Richard
Article

Selection and design of industrial crystallizers

Handbook of Industrial Crystallization / Edited by Allan S. Myerson, Deniz Erdemir, Alfred Y. Lee. Cambridge : Cambridge University Press, 2019, p. 197-215, Ch. 7
Kramer, Herman J.M.; Lakerveld, Richard
Book chapter

3D Printed Static mixers for Continuous Reactive Crystallization

Mathew Thomas, Kiran; Lakerveld, Richard
Conference paper

A Dynamic Model for Automated Control of Directed Self-assembly of Colloidal Particles at Low Densities

Computer Aided Chemical Engineering, v. 46, 2019, p. 1783-1788
Nyande, Baggie Waponde; Gao, Yu; Lakerveld, Richard
Conference paper

A Workflow for the Fabrication of Innovative Crystallizers Using 3D-Printing

Mathew Thomas, Kiran; Lakerveld, Richard
Conference paper

Automated Open-loop Control of Directed Self-assembly With Multiple Electrokinetic Actuators in Microfluidic Devices

Computer Aided Chemical Engineering, v. 46, 2019, p. 43-48
Gao, Yu; Lakerveld, Richard
Conference paper

Continuous Protein Crystallization in a 3D Printed Airlift Crystallizer

Mathew Thomas, Kiran; Jin, Yi; Lakerveld, Richard
Conference paper

Open-Loop Optimal Control of Directed Self-Assembly of Colloidal Particles in a Microfluidic Device

AIChE Annual Meeting 2019, Orlando, Fl, USA, 10-15 November 2019
Nyande, Baggie Waponde; Lakerveld, Richard
Conference paper

2018 12

11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons

CrystEngComm, v. 20, (9), March 2018, p. 1205-1219
Nisar, Madiha; Sung, Ho Yung; Puschmann, Horst; Lakerveld, Richard; Haynes, Richard Kingston; Williams, Ian Duncan
Article

A review on recent technologies for the manufacture of pulmonary drugs

Therapeutic Delivery, v. 9, (1), January 2018, p. 47-70
Hadiwinoto, Gabriela Daisy; Lip Kwok, Philip Chi; Lakerveld, Richard
Article

Control system implementation and plant-wide control of continuous pharmaceutical manufacturing pilot plant (end-to-end manufacturing process)

Computer Aided Chemical Engineering: Process Systems Engineering for Pharmaceutical Manufacturing, v. 41, 2018, p. 403-430
Lakerveld, Richard
Article

Design, Characterization and Model Validation of a LED-based Photocatalytic Reactor for Gas Phase Applications

Chemical Engineering Journal, v. 333, February 2018, p. 456-466
Khodadadian, Fatemeh; De boer, Merijn W.; Poursaeidesfahani, Ali; Van ommen, J. Ruud; Stankiewicz, Andrzej I.; Lakerveld, Richard
Article

Electric-Field-Assisted Protein Crystallization in Continuous Flow

Crystal Growth & Design, v. 18, (5), May 2018, p. 2964-2971
Li, Fei; Lakerveld, Richard
Article

Feedback control for defect-free alignment of colloidal particles

Lab on a Chip, v. 18, (14), July 2018, p. 2099-2110
Gao, Yu; Lakerveld, Richard
Article

Process Intensification for Pharmaceutical Crystallization

Chemical Engineering and Processing Process Intensification, v. 127, May 2018, p. 111-126
Wang, Jiayuan; Li, fei; Lakerveld richard
Article

3D Printing for Rapid Prototyping of Innovative Process Equipment for Pharmaceutical Crystallization

Mathew Thomas, Kiran; Ik shin, Dong; Lakerveld, Richard
Conference paper

Batch Crystallization of Rifapentine for Inhalable Tuberculosis Medication

AIP Conference Proceedings, v. 1933, February 2018, article number 030023
Wijanarko, Anondho; Meivita, Maria Prisca; Hermansyah, Heri; Sahlan, Muhamad; Lakerveld, Richard
Conference paper

Experimental validation of scheduled PID control for directed self-assembly of colloidal particles in microfluidic devices

Computer Aided Chemical Engineering, v. 44, 2018, p. 2455-2460
Gao, Yu; Lakerveld, Richard
Conference paper

Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling

Computer Aided Chemical Engineering, v. 44, July 2018, p. 1051-1056
Wang, Jiayuan; Lakerveld, Richard
Conference paper

Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling

Wang, Jiayuan; Lakerveld, Richard
Conference paper

2017 8

An Optimization-based Approach for Structural Design of Self-assembled DNA Tiles

AIChE Journal, 63, 6, June 2017, p. 1804-1817
Gao, Yu; Mi, Yongli; Lakerveld, Richard
Article

Continuous Membrane-Assisted Crystallization To Increase the Attainable Product Quality of Pharmaceuticals and Design Space for Operation

Industrial & Engineering Chemistry Research, v. 56, (19), May 2017, p. 5705-5714
Wang, Jiayuan; Lakerveld, Richard
Article

Influence of Alternating Electric Fields on Protein Crystallization in Microfluidic Devices with Patterned Electrodes in a Parallel-Plate Configuration

Crystal Growth and Design, v. 17, (6), June 2017, p. 3062-3070
Li, Fei; Lakerveld, Richard
Article

Model Predictive Control of an Integrated Continuous Pharmaceutical Manufacturing Pilot Plant

Organic Process Research & Development, v. 21, (6), June 2017, p. 844-854
Mesbah, Ali; Paulson, Joel.A.; Lakerveld, Richard; Braatz, Richard D.
Article

End to End Continuous Manufacturing: Integration of Unit Operations

Continuous Manufacturing of Pharmaceuticals / Peter Kleinebudde, Johannes Khinast, and Jukka Rantanen. John Wiley & Sons Ltd, 2017, p. 447-483
Lakerveld, Richard; Heider, P.L.; Jensen, K.D.; Braatz, R.D.; Jensen, K.F.; Myerson, A.S.; Trout, B.L.
Book chapter

Continuous crystallization of an active pharmaceutical ingredient for pulmonary drug delivery

Hadiwinoto, gabriela d.; Kwok, philip c.l.; Tong, henry h.y.; Lakerveld, Richard
Conference paper

Electric-field-assisted protein crystallization in microfluidic devices with patterned electrodes in a parallel-plate configuration

Li, Fei; Lakerveld, Richard
Conference paper

Integrated Solvent and Process Design Using PC-SAFT for Continuous Anti-Solvent Crystallization Including Solvent Recycling

Wang, Jiayuan; Lakerveld, Richard
Conference paper

2016 4

Microwave Assisted Direct Nucleation Control for Batch Crystallization: Crystal Size Control with Reduced Batch Time

Crystal Growth and Design, v. 16, (1), January 2016, p. 440-446
Kacker, Rohit; Salvador, Pedro M.; Sturm, Guidso S. J.; Stefanidis, Georgios D.; Lakerveld, Richard; Nagy, Zoltan K.; Kramer, Herman J. M.
Article

Model-Based Optimization of a Photocatalytic Reactor with Light-Emitting Diodes

Chemical Engineering and Technology, v. 39, (10), October 2016, p. 1946-1954
Khodadadian, Fatemeh; Poursaeidesfahani, Ali; Li, Zonghan; van Ommen, J. Ruud; Stankiewicz, Andrzej I.; Lakerveld, Richard
Article

Photocatalysis: Past Achievements and Future Trends

Alternative Energy Sources for Green Chemistry / Edited by Georgios Stefanidis, Andrzej Stankiewicz. Cambridge, UK : The Royal Society of Chemistry, 2016, p. 227-269, Ch. 8, Book series: Green Chemistry, v. 47
Khodadadian, Fatemeh; Nasalevich, Maxim; Kapteijn, Freek; Stankiewicz, Andrzej I.; Lakerveld, Richard; Gascon, Jorge
Book chapter

Modelling and Experimental Validation of An Annular LED-based Photocatalytic Reactor

22nd International Congress of Chemical and Process Engineering, CHISA 2016 and 19th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, PRES 2016, v. 1, 2016, p. 39-40
Khodadadian, Fatemeh; De Boer, Merijn W.; Van Ommen, J. Ruud; Stankiewicz, Andrzej; Lakerveld, Richard
Conference paper

2015 5

Controlled formation of nanostructures with desired geometries: Part 3. Dynamic modeling and simulation of directed self-assembly of nanoparticles through adaptive finite state projection

Industrial and Engineering Chemistry Research, v. 54, (16), April 2015, p. 4371-4384
Ramaswamy, Sivaraman; Lakerveld, Richard; Barton, Paul I.; Stephanopoulos, George
Article

The Application of an Automated Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant

Organic process research & development, v. 19, (9), 2015, p. 1088-1100
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick l.; Zhang, Haitao; Wolfe, Aaron; Testa, Christopher j.; Ogden, Sean; Hersey, Devin r.; Mascia, Salvatore; Evans, James M.B.; Braatz, Richard D.; Barton, Paul I.
Article

Model-based Optimization of a LED-based Photocatalytic Reactor

Catalysis and Reaction Engineering Division 2015: Core Programming Area at the 2015 AIChE Annual Meeting, American Institute of Chemical Engineers (AIChE), 2015, p. 470-472
Khodadadian, Fatemeh; Li, Zonghan; Van ommen, Ruud; Stankiewicz, Andrzej; Lakerveld, Richard
Conference paper

Model-based Optimization of LED-based photocatalytic reactors

Khodadadian, Fatemeh; Li, Zonghan; Stankiewicz, Andrzej; Lakerveld, Richard
Conference paper

Plant-wide Model Predictive Control for a Continuous Pharmaceutical Process

2015 American Control Conference (ACC 2015) /IEEE. New York, USA : Institute of Electrical and Electronics Engineers (IEEE), 2015, p. 4301-4307
Mesbah, Ali; Paulson, Joel A.; Lakerveld, Richard; Braatz, Richard D.
Conference paper

2014 6

An Air-Lift Crystallizer Can Suppress Secondary Nucleation at a Higher Supersaturation Compared to a Stirred Crystallizer

Crystal Growth and Design, v. 14, (7), July 2014, p. 3264-3275
Lakerveld, Richard; Van Krochten, Jeroen J.H.; Kramer, Herman J.M.
Article

Application of Continuous Crystallization in an Integrated Continuous Pharmaceutical Pilot Plant

Crystal growth & design, v. 14, (5), May 2014, p. 2148-2157
Zhang, Haitao; Lakerveld, Richard; Heider, Patrick L.; Tao, Mengying; Su, Min; Testa, Christopher J.; D'Antonio, Alyssa N.; Barton, Paul I.; Braatz, Richard D.; Trout, Bernhardt L.; Myerson, Allan S.; Jensen, Klavs F.; Evans, James M.B.
Article

Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

Organic Process Research and Development, v. 18, (3), March 2014, p. 402-409
Heider, Patrick L.; Born, Stephen C.; Basak, Soubir; Benyahia, Brahim; Lakerveld, Richard; Zhang, Haitao; Hogan, Rachael; Buchbinder, Louis; Wolfe, Aaron; Mascia, Salvatore; Evans, James M.B.; Jamison, Timothy F.; Jensen, Klavs F.
Article

Integrated design of microwave and photocatalytic reactors. Where are we now?

Current Opinion in Chemical Engineering, v. 5, 2014, p. 37-41
Lakerveld, Richard; Sturm, Gsj S.J.; Stankiewicz, Ai I.; Stefanidis, Georgios D.
Article

Microwave Assisted Fines Control during Crystallization

BIWIC 2014 : 21st International workshop on industrial crystallization : September 10-12, 2014, University of Rouen, France, Gérard Coquerel, Yohann Cartigny, Nicolas Couvrat. Mont-Saint-Aignan : Presses universitaires de Rouen et du Havre, 2014, p. 97-104
Kacker, R.; Lakerveld, Richard; Kramer, Herman J.M.
Conference paper

The application of an automated plant-wide control strategy for a continuous pharmaceutical pilot plant

Proceedings of the American Control Conference, 2014, article number 6858854, p. 3512-3517
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick L.; Zhang, Haitao; Wolfe, Aaron; Testa, Christopher J.; Ogden, Sean; Hersey, Devin R.; Mascia, Salvatore; Evans, James M.B.; Braatz, Richard D.; Barton, Paul I.
Conference paper

2013 5

Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant

Processes, v. 1, (3), November 2013, p. 330-348
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick L.; Zhang, Haitao; Braatz, Richard D.; Barton, Paul I.
Article

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

Angewandte Chemie - International Edition, v. 52, (47), November 2013, p. 12359-12363
Mascia, Salvatore; Heider, Patrick L.; Zhang, Haitao; Lakerveld, Richard; Benyahia, Brahim; Barton, Paul I.; Braatz, Richard D.; Cooney, Charles L.; Evans, James M.B.; Jamison, Timothy F.; Jensen, Klavs F.; Myerson, Allan S.; Trout, Bernhardt L.
Article

Model-Based Design of a Plant-Wide Control Strategy for a Continuous Pharmaceutical Plant

AIChE Journal, v. 59, (10), October 2013, p. 3671-3685
Lakerveld, Richard; Benyahia, Brahim; Braatz, Richard D.; Barton, Paul I.
Article

Crystallization of L-ascorbic acid in a 18-L airlift crystallizer

Pharmaceutical Discovery, Development and Manufacturing Forum 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, 2013, p. 142-143
Lakerveld, Richard; Van krochten, Jeroen; Anisi, Fatemeh; Stankiewicz, Andrzej; Kramer, Herman
Conference paper

Membrane-assisted Crystallization of L-ascorbic Acid

Lakerveld, Richard; Goddrie, S.F.M.; Anisi, Fatemeh; Stankiewicz, Andrzej I.; Kramer, Herman J.M.
Conference paper

2012 3

A master-equation approach to simulate kinetic traps during directed self-assembly

The Journal of Chemical Physics, v. 136, (18), May 2012, article number 184109
Lakerveld, Richard; Stephanopoulos, George; Barton, Paul I.
Article

A Plant-Wide Dynamic Model of a Continuous Pharmaceutical Process

Industrial & Engineering Chemistry Research, v. 51, (47), November 2012, p. 15393-15412
Benyahia, Brahim; Lakerveld, Richard; Barton, Paul I.
Article

Minimization of Attrition and Breakage in an Airlift Crystallizer

Industrial & Engineering Chemistry Research, v. 51, (33), August 2012, p. 10895-10909
Soare, Anamaria; Lakerveld, Richard; Van Royen, Jurjen; Zocchi, Giorgia; Stankiewicz, Andrzej I.; Kramer, Herman J.M.
Article

2011 2

Application of Ultrasound for Start-Up of Evaporative Batch Crystallization of Ammonium Sulfate in a 75-L Crystallizer

AIChE Journal, v. 57, (12), December 2011, p. 3367-3377
Lakerveld, Richard; Verzijden, Nelleke G.; Kramer, Herman; Jansens, Peter; Grievink, Johan
Article

Towards robust fabrication of non-periodic nanoscale systems via directed self assembly

Computer-aided chemical engineering, v. 29, 2011, p. 1603-1607
Lakerveld, Richard; Stephanopoulos, George; Barton, Paul I.
Conference paper

2010 3

Application of generic principles of process intensification to solution crystallization enabled by a task-based design approach

Chemical Engineering and Processing: Process Intensification, v. 49, (9), September 2010, p. 979-991
Lakerveld, Richard; Kramer, Herman J.M.; Stankiewicz, Andrzej I.; Grievink, Johan
Article

Membrane assisted crystallization using reverse osmosis: Influence of solubility characteristics on experimental application and energy saving potential

Chemical Engineering Science, v. 65, (9), May 2010, p. 2689-2699
Lakerveld, Richard; Kuhn, Jelan; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Article

A Plant-Wide Control Strategy for Continuous Pharmaceutical Manufacturing

AlChE, 10 Nov 2010
Lakerveld, Richard; Braatz, Richard D.; Barton, Paul I.
Conference paper

2009 5

Characterization and Dynamic Optimization of Membrane-Assisted Crystallization of Adipic Acid

Industrial & Engineering Chemistry Research, v. 48, (11), June 2009, p. 5360-5369
Kuhn, Jelan; Lakerveld, Richard; Kramer, Herman J.M.; Grievink, Johan; Jansens, Peter J.
Article

The application of a task-based concept for the design of innovative industrial crystallizers

Computers & Chemical Engineering, v. 33, (10), October 2009, p. 1692-1700, Selected Papers from the 18th European Symposium on Computer Aided Process Engineering (ESCAPE-18)
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Article

Opportunities for process intensification in crystallization: application of air-mixed devices

EPIC 2009 Conference Proceedings, Venice, Italy, 2009
Lakerveld, R.; Kramer, H.J.M.; Stankiewicz, A.I.; Jansens, P.J.; Grievink, J.
Conference paper

The Application of a Task Based Design Approach to Solution Crystallization

Design for Energy and the Environment: Proceedings of the Seventh International Conference on the Foundations of Computer-Aided Process Design, Breckenridge, Colorado, United States, 2009
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Conference paper

The Application of a Task-Based Concept for Design of Innovative Industrial Crystallizers

Computer-aided chemical engineering, v. 27, 2009, p. 909-914
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Conference paper

2008 6

A task based design approach for solution crystallization

BIWIC 2008 - 15th International Workshop on Industrial Crystallization, Aachen, Germany, 10-12 September 2008 p. 95-102
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

A Task Based Design Approach for Solution Crystallization

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 27-34
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

Membrane Assisted Evaporative Crystallization: Optimization of Task Supersaturation Generation

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 827-834
Lakerveld, R.; Kuhn, J.; Bosch, M.A.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

Solution Crystallization in a Bubble Column Optimization of the task: Crystal Growth

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 819-826
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

The Application Of A Task-Based Concept For The Design Of Innovative Industrial Crystallizers

Computer-aided chemical engineering, v. 25, 2008, p. 103-108
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Conference paper

The Application of Ultrasound for Seeding Purposes Optimization of the task: Nucleation

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 835-842
Lakerveld, R.; Verzijden, P.G.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

2007 2

Novel design strategies for solution crystallization processes

AIChE Annual Meeting, Conference Proceedings, 2007
Kramer, Herman J.M.; Lakerveld, Richard; Jansens, Peter J.; Grievink, Johan
Conference paper

The application of different seeding techniques for solution crystallization of ammonium sulphate

BIWIC 2007, 2007, p. 221-228
Lakerveld, Richard; Kalbasenka, A.N.; Kramer, Herman J.M.; Grievink, Johan; Jansens, Peter J.
Conference paper

2006 1

Task based design techniques for solution crystallisation processes: Application to a bubble column setup

BIWIC 2006, 2006, p. 114-121
Lakerveld, Richard; Djatmiko, M.E.; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Conference paper

2005 1

Exothermic isomerization reaction in a reactive flash: Steady-state behavior

Industrial & Engineering Chemistry Research, v. 44, (10), May 2005, p. 3815-3822
Lakerveld, Richard; Bildea, Costin Sorin; Almeida-Rivera, Cristhian P.
Article

Article 1

Data-driven identification of crystallization kinetics

Aiche Journal, v. 70, (5), May 2024, article number e18333
Nyande, Baggie Waponde; Nagy, Zoltan K.; Lakerveld, Richard

Article 5

A Workflow for Crystallization Process Design with Simultaneous Process Optimization and Solvent Selection based on the Perturbed-Chain Statistical Associating Fluid Theory

Chemie Ingenieur Technik, v. 95, (3), March 2023, p. 334-343
Mendis, Nethrue Pramuditha; Wang, Jiayuan; Lakerveld, Richard

An In Vitro Model for Cocrystal Dissolution with Simultaneous Surface and Bulk Precipitation

Molecular Pharmaceutics, v. 20, (11), November 2023, p. 5486-5499
Mendis, Nethrue Pramuditha; Lakerveld, Richard

Induced-charge electroosmosis for rapid mixing of reactive precipitation systems to obtain small and uniform particles

Chemical Engineering Research and Design, v. 190, February 2023, p. 715-729
Gupta, Dishika; Nyande, Baggie Waponde; Mathew Thomas, Kiran; Li, Fei; Mak, Andrew T.C.; Lakerveld, Richard

Integrated Selection of Coformers, Solvents, and Operating Conditions for Optimal Process and Product Performance of Pharmaceutical Cocrystals

Industrial & Engineering Chemistry Research, v. 62, (33), 14 August 2023, p. 13081-13095
Mendis, Nethrue Pramuditha; Li, Jiatao; Lakerveld, Richard

Solvent selection for chemical reactions toward optimal thermodynamic and kinetic performances: Group contribution and COSMO-based modeling

Fluid Phase Equilibria, v. 564, January 2023, article number 113623
Wang, Jiayuan; Song, Zhen; Lakerveld, Richard; Zhou, Teng

Article 8

Control of crystal size distribution in batch protein crystallization by integrating a gapped Kenics static mixer to flexibly produce seed crystals

Chemical Engineering Science, v. 263, December 2022, article number 118085
Nyande, Baggie Waponde; Mathew Thomas, Kiran; Takarianto, Abraham Aditya; Lakerveld, Richard

Design and Characterization of Kenics Static Mixer Crystallizers

Chemical Engineering Research and Design, v. 179, March 2022, p. 549-563
Mathew Thomas, Kiran; Nyande, Baggie Waponde; Lakerveld, Richard

Directed assembly of genetically engineered eukaryotic cells into living functional materials via ultrahigh-affinity protein interactions

Science Advances, v. 8, (44), 4 November 2022, article number eade0073
Yi, Qikun; Dai, Xin; Park, Byung Min; Gu, Junhao; Luo, Jiren; Wang, Ri; Yu, Cong; Kou, Songzi; Huang, Jinqing; Lakerveld, Richard; Sun, Fei

Impact of Cooling Profile on Batch Emulsion Solution Crystallization

Industrial and Engineering Chemistry Research, v. 61, (30), August 2022, p. 11108-11115
Kwon, Soo Jin; Lakerveld, Richard

Integrated membrane emulsification and solution cooling crystallization to obtain a narrow and predictable crystal size distribution

Chemical Engineering and Processing: Process Intensification, v. 171, January 2022, article number 108751
Kwon, Soo Jin; Mathew Thomas, Kiran; Lakerveld, Richard

Rational Development of a Carrier-Free Dry Powder Inhalation Formulation for Respiratory Viral Infections via Quality by Design: A Drug-Drug Cocrystal of Favipiravir and Theophylline

Pharmaceutics, v. 14, (2), February 2022, article number 300
Wong, Si Nga; Weng, Jingwen; Ip, Ignatius; Chen, Ruipeng; Lakerveld, Richard; Telford, Richard; Blagden, Nicholas; Scowen, Ian J.; Chow, Shing Fung

Simultaneous Solvent Selection and Process Design for Continuous Reaction–Extraction–Crystallization Systems

Industrial & Engineering Chemistry Research, v.61, (31), August 2022, p. 11504-11517
Mendis, Nethrue Pramuditha; Wang, Jiayuan; Lakerveld, Richard

Staged Assembly of Colloids Using DNA and Acoustofluidics

Nano Letters, v. 22, (17), 14 September 2022, p. 6907-6915
Gao, Yu; Liu, Kun; Lakerveld, Richard; Ding, Xiaoyun

Conference paper 1

A Thermodynamic Approach for Simultaneous Solvent, Coformer, and Process Optimization of Continuous Cocrystallization Processes

Proceedings of the 14th International Symposium on Process Systems Engineering – PSE 2021+, v. 49, June 2022, p. 2179-2184
Mendis, Nethrue Pramuditha; Lakerveld, Richard

Article 7

CFD Analysis of a Kenics Static Mixer with a Low Pressure Drop under Laminar Flow Conditions

Industrial & Engineering Chemistry Research, v. 60, (14), April 2021, p. 5264-5277
Nyande, Baggie Waponde; Mathew Thomas, Kiran; Lakerveld, Richard

Characterization of Single-Cell Osmotic Swelling Dynamics for New Physical Biomarkers

Analytical Chemistry, v. 93, (3), 26 January 2021, p. 1317-1325
Fajrial, Apresio K.; Liu, Kun; Gao, Yu; Gu, Junhao; Lakerveld, Richard; Ding, Xiaoyun

Continuous Protein Crystallization in Mixed-Suspension Mixed-Product-Removal Crystallizers

Crystal Growth and Design, v. 21, (2), 3 February 2021, p. 757-769
Mathew Thomas, Kiran; Kwon, Soo Jin; Lakerveld, Richard

DNA dynamics and computation based on toehold-free strand displacement

Nature Communications, v. 12, (1), August 2021, article number 4994
Kang, Hong; Lin, Tong; Xu, Xiaojin; Jia, Qing-Shan; Lakerveld, Richard; Wei, Bryan

Impact of cocrystal solution-state stability on cocrystal dissociation and polymorphic drug recrystallization during dissolution

International Journal of Pharmaceutics, v. 610, December 2021, article number 121239
Xuan, Bianfei; Chen, Yu Chee Sonia; Wong, Kong Ching; Chen, Ruipeng; Lo, Po Sang; Lakerveld, Richard; Tong, Henry Hoi Yee; Chow, Shing Fung

Integrated Continuous Crystallization and Spray Drying of Insulin for Pulmonary Drug Delivery

Crystal Growth & Design, v. 21, (1), January 2021, p. 501-511
Chen, Ruipeng; Weng, Jingwen; Chow, Shing Fung; Lakerveld, Richard

Process modeling and optimization of continuous chiral resolution by integration of membrane and crystallization technologies

Journal of Membrane Science, v. 632, August 2021, article number 119359
Capdevila-Echeverria, Jose; Wang, Jiayuan; Lakerveld, Richard; Ter Horst, Joop H.

Conference paper 3

A 3D-Printed Low Pressure-Drop Plug-Flow Crystallizer for Protein Crystallization

Nyande, Baggie Waponde; Mathew Thomas, Kiran; Lakerveld, Richard

The Development of a Crystallization-Based Process for the Enantiomeric Enrichment of an Active Ingredient Derived from Traditional Chinese Medicine

Lo, Po Sang; Lakerveld, Richard

The integration of membrane emulsification and cooling crystallization of glycine

Kwon, Soo Jin; Mathew Thomas, Kiran; Lakerveld, Richard

Article 4

A hybrid framework for simultaneous process and solvent optimization of continuous anti-solvent crystallization with distillation for solvent recycling

Processes, v. 8, (1), January 2020, article number 63
Wang, Jiayuan; Zhu, Lingyu; Lakerveld, Richard

An Ion-Specific Electrolyte Non-Random Two-Liquid Segment Activity Coefficient Model with Improved Predictive Capabilities for Aqueous Electrolyte Solutions

Fluid Phase Equilibria, v. 517, August 2020, article number 112605
Wang, Jiayuan; Li, Jintao; Cao, Wenqi; Zhu, Lingyu; Lakerveld, Richard

Emulsion-assisted cooling crystallization of ibuprofen

Chemical Engineering Science, v. 226, 23 November 2020, article number 115861
Wang, Jiayuan; Cao, Wenqi; Zhu, Lingyu; Wang, Jianli; Lakerveld, Richard

Open-loop control of directed self-assembly of colloidal particles in a microfluidic device

Computers & Chemical Engineering, v. 139, 4 August 2020, article number 106837
Gao, Yu; Nyande, Baggie Waponde; Lakerveld, Richard

Book chapter 2

Process Control

The Handbook of Continuous Crystallization / Edited by Nima Yazdanpanah, Zoltan K Nagy. London : Royal Society of Chemistry, 2020, p. 172-218, Ch. 4
Lakerveld, Richard; Benyahia, Brahim

Process Intensification in Continuous Crystallization

The Handbook of Continuous Crystallization / Edited by Nima Yazdanpanah, Zoltan K Nagy. London : Royal Society of Chemistry, 2020, p. 266-320, Ch. 7
Stelzer, T.; Lakerveld, Richard; Myerson, A.S.

Conference paper 3

A Thermodynamic Approach for Simultaneous Solvent and Process Design of Continuous Reactive Crystallization with Recycling

Computer Aided Chemical Engineering, v. 48, 2020, p. 805-810
Mendis, Nethrue Pramuditha; Wang, Jiayuan; Lakerveld, Richard

Integrated Continuous Crystallization and Spray Drying of Insulin

AIChE Annual Meeting, Conference Proceedings, v. 2020-November, 2020
Chen, Ruipeng; Weng, Jingwen; Chow, Shing Fung; Lakerveld, Richard

Simultaneous Solvent and Process Optimization of Continuous Reactive Crystallization Processes Involving Electrolytes and Recycling Using the Electrolyte PC-SAFT

2020 Virtual AIChE Annual Meeting proceedings, v. 2020-November, November 2020
Mendis, Nethrue Pramuditha; Wang, Jiayuan; Lakerveld, Richard

Article 6

An Airlift Crystallizer for Protein Crystallization

Industrial & Engineering Chemistry Research, v. 58, (44), November 2019, p. 20381-20391
Mathew Thomas, Kiran; Lakerveld, Richard

Cocrystal Engineering of Itraconazole with Suberic Acid via Rotary Evaporation and Spray Drying

Crystal Growth and Design, v. 19, (5), May 2019, p. 2736-2745
Weng, Jingwen; Wong, Singa; Xu, Xiaoyan; Xuan, Bianfei; Wang, Chenguang; Chen, Ruipeng; Sun, Changquan Calvin; Lakerveld, Richard; Kwok, Philip Chi Lip; Chow, Shing Fung

Feedback Control for Shaping Density Distributions of Colloidal Particles in Microfluidic Devices

Lab on a Chip, v. 19, (13), July 2019, p. 2168-2177
Gao, Yu; Lakerveld, Richard

Gain scheduling PID control for directed self‐assembly of colloidal particles in microfluidic devices

AIChE Journal, v. 65, (6), June 2019, article number e16582
Gao, Yu; Lakerveld, Richard

Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation

Industrial and Engineering Chemistry Research, v. 58, (36), August 2019, p. 16843-16857
Hadiwinoto, Gabriela Daisy; Kwok, Philip Chi Lip; Tong, Henry H.Y.; Wong, Singa; Chow, Shingfung; Lakerveld, Richard

The application of automated feedback and feedforward control to a LED-based photocatalytic reactor

Chemical Engineering Journal, v. 362, April 2019, p. 375-382
Khodadadian, Fatemeh; De La Garza, Francisco Galnares; Van Ommen, J. Ruud; Stankiewicz, Andrzej I.; Lakerveld, Richard

Book chapter 1

Selection and design of industrial crystallizers

Handbook of Industrial Crystallization / Edited by Allan S. Myerson, Deniz Erdemir, Alfred Y. Lee. Cambridge : Cambridge University Press, 2019, p. 197-215, Ch. 7
Kramer, Herman J.M.; Lakerveld, Richard

Conference paper 6

3D Printed Static mixers for Continuous Reactive Crystallization

Mathew Thomas, Kiran; Lakerveld, Richard

A Dynamic Model for Automated Control of Directed Self-assembly of Colloidal Particles at Low Densities

Computer Aided Chemical Engineering, v. 46, 2019, p. 1783-1788
Nyande, Baggie Waponde; Gao, Yu; Lakerveld, Richard

A Workflow for the Fabrication of Innovative Crystallizers Using 3D-Printing

Mathew Thomas, Kiran; Lakerveld, Richard

Automated Open-loop Control of Directed Self-assembly With Multiple Electrokinetic Actuators in Microfluidic Devices

Computer Aided Chemical Engineering, v. 46, 2019, p. 43-48
Gao, Yu; Lakerveld, Richard

Continuous Protein Crystallization in a 3D Printed Airlift Crystallizer

Mathew Thomas, Kiran; Jin, Yi; Lakerveld, Richard

Open-Loop Optimal Control of Directed Self-Assembly of Colloidal Particles in a Microfluidic Device

AIChE Annual Meeting 2019, Orlando, Fl, USA, 10-15 November 2019
Nyande, Baggie Waponde; Lakerveld, Richard

Article 7

11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons

CrystEngComm, v. 20, (9), March 2018, p. 1205-1219
Nisar, Madiha; Sung, Ho Yung; Puschmann, Horst; Lakerveld, Richard; Haynes, Richard Kingston; Williams, Ian Duncan

A review on recent technologies for the manufacture of pulmonary drugs

Therapeutic Delivery, v. 9, (1), January 2018, p. 47-70
Hadiwinoto, Gabriela Daisy; Lip Kwok, Philip Chi; Lakerveld, Richard

Control system implementation and plant-wide control of continuous pharmaceutical manufacturing pilot plant (end-to-end manufacturing process)

Computer Aided Chemical Engineering: Process Systems Engineering for Pharmaceutical Manufacturing, v. 41, 2018, p. 403-430
Lakerveld, Richard

Design, Characterization and Model Validation of a LED-based Photocatalytic Reactor for Gas Phase Applications

Chemical Engineering Journal, v. 333, February 2018, p. 456-466
Khodadadian, Fatemeh; De boer, Merijn W.; Poursaeidesfahani, Ali; Van ommen, J. Ruud; Stankiewicz, Andrzej I.; Lakerveld, Richard

Electric-Field-Assisted Protein Crystallization in Continuous Flow

Crystal Growth & Design, v. 18, (5), May 2018, p. 2964-2971
Li, Fei; Lakerveld, Richard

Feedback control for defect-free alignment of colloidal particles

Lab on a Chip, v. 18, (14), July 2018, p. 2099-2110
Gao, Yu; Lakerveld, Richard

Process Intensification for Pharmaceutical Crystallization

Chemical Engineering and Processing Process Intensification, v. 127, May 2018, p. 111-126
Wang, Jiayuan; Li, fei; Lakerveld richard

Conference paper 5

3D Printing for Rapid Prototyping of Innovative Process Equipment for Pharmaceutical Crystallization

Mathew Thomas, Kiran; Ik shin, Dong; Lakerveld, Richard

Batch Crystallization of Rifapentine for Inhalable Tuberculosis Medication

AIP Conference Proceedings, v. 1933, February 2018, article number 030023
Wijanarko, Anondho; Meivita, Maria Prisca; Hermansyah, Heri; Sahlan, Muhamad; Lakerveld, Richard

Experimental validation of scheduled PID control for directed self-assembly of colloidal particles in microfluidic devices

Computer Aided Chemical Engineering, v. 44, 2018, p. 2455-2460
Gao, Yu; Lakerveld, Richard

Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling

Computer Aided Chemical Engineering, v. 44, July 2018, p. 1051-1056
Wang, Jiayuan; Lakerveld, Richard

Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling

Wang, Jiayuan; Lakerveld, Richard

Article 4

An Optimization-based Approach for Structural Design of Self-assembled DNA Tiles

AIChE Journal, 63, 6, June 2017, p. 1804-1817
Gao, Yu; Mi, Yongli; Lakerveld, Richard

Continuous Membrane-Assisted Crystallization To Increase the Attainable Product Quality of Pharmaceuticals and Design Space for Operation

Industrial & Engineering Chemistry Research, v. 56, (19), May 2017, p. 5705-5714
Wang, Jiayuan; Lakerveld, Richard

Influence of Alternating Electric Fields on Protein Crystallization in Microfluidic Devices with Patterned Electrodes in a Parallel-Plate Configuration

Crystal Growth and Design, v. 17, (6), June 2017, p. 3062-3070
Li, Fei; Lakerveld, Richard

Model Predictive Control of an Integrated Continuous Pharmaceutical Manufacturing Pilot Plant

Organic Process Research & Development, v. 21, (6), June 2017, p. 844-854
Mesbah, Ali; Paulson, Joel.A.; Lakerveld, Richard; Braatz, Richard D.

Book chapter 1

End to End Continuous Manufacturing: Integration of Unit Operations

Continuous Manufacturing of Pharmaceuticals / Peter Kleinebudde, Johannes Khinast, and Jukka Rantanen. John Wiley & Sons Ltd, 2017, p. 447-483
Lakerveld, Richard; Heider, P.L.; Jensen, K.D.; Braatz, R.D.; Jensen, K.F.; Myerson, A.S.; Trout, B.L.

Conference paper 3

Continuous crystallization of an active pharmaceutical ingredient for pulmonary drug delivery

Hadiwinoto, gabriela d.; Kwok, philip c.l.; Tong, henry h.y.; Lakerveld, Richard

Electric-field-assisted protein crystallization in microfluidic devices with patterned electrodes in a parallel-plate configuration

Li, Fei; Lakerveld, Richard

Integrated Solvent and Process Design Using PC-SAFT for Continuous Anti-Solvent Crystallization Including Solvent Recycling

Wang, Jiayuan; Lakerveld, Richard

Article 2

Microwave Assisted Direct Nucleation Control for Batch Crystallization: Crystal Size Control with Reduced Batch Time

Crystal Growth and Design, v. 16, (1), January 2016, p. 440-446
Kacker, Rohit; Salvador, Pedro M.; Sturm, Guidso S. J.; Stefanidis, Georgios D.; Lakerveld, Richard; Nagy, Zoltan K.; Kramer, Herman J. M.

Model-Based Optimization of a Photocatalytic Reactor with Light-Emitting Diodes

Chemical Engineering and Technology, v. 39, (10), October 2016, p. 1946-1954
Khodadadian, Fatemeh; Poursaeidesfahani, Ali; Li, Zonghan; van Ommen, J. Ruud; Stankiewicz, Andrzej I.; Lakerveld, Richard

Book chapter 1

Photocatalysis: Past Achievements and Future Trends

Alternative Energy Sources for Green Chemistry / Edited by Georgios Stefanidis, Andrzej Stankiewicz. Cambridge, UK : The Royal Society of Chemistry, 2016, p. 227-269, Ch. 8, Book series: Green Chemistry, v. 47
Khodadadian, Fatemeh; Nasalevich, Maxim; Kapteijn, Freek; Stankiewicz, Andrzej I.; Lakerveld, Richard; Gascon, Jorge

Conference paper 1

Modelling and Experimental Validation of An Annular LED-based Photocatalytic Reactor

22nd International Congress of Chemical and Process Engineering, CHISA 2016 and 19th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, PRES 2016, v. 1, 2016, p. 39-40
Khodadadian, Fatemeh; De Boer, Merijn W.; Van Ommen, J. Ruud; Stankiewicz, Andrzej; Lakerveld, Richard

Article 2

Controlled formation of nanostructures with desired geometries: Part 3. Dynamic modeling and simulation of directed self-assembly of nanoparticles through adaptive finite state projection

Industrial and Engineering Chemistry Research, v. 54, (16), April 2015, p. 4371-4384
Ramaswamy, Sivaraman; Lakerveld, Richard; Barton, Paul I.; Stephanopoulos, George

The Application of an Automated Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant

Organic process research & development, v. 19, (9), 2015, p. 1088-1100
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick l.; Zhang, Haitao; Wolfe, Aaron; Testa, Christopher j.; Ogden, Sean; Hersey, Devin r.; Mascia, Salvatore; Evans, James M.B.; Braatz, Richard D.; Barton, Paul I.

Conference paper 3

Model-based Optimization of a LED-based Photocatalytic Reactor

Catalysis and Reaction Engineering Division 2015: Core Programming Area at the 2015 AIChE Annual Meeting, American Institute of Chemical Engineers (AIChE), 2015, p. 470-472
Khodadadian, Fatemeh; Li, Zonghan; Van ommen, Ruud; Stankiewicz, Andrzej; Lakerveld, Richard

Model-based Optimization of LED-based photocatalytic reactors

Khodadadian, Fatemeh; Li, Zonghan; Stankiewicz, Andrzej; Lakerveld, Richard

Plant-wide Model Predictive Control for a Continuous Pharmaceutical Process

2015 American Control Conference (ACC 2015) /IEEE. New York, USA : Institute of Electrical and Electronics Engineers (IEEE), 2015, p. 4301-4307
Mesbah, Ali; Paulson, Joel A.; Lakerveld, Richard; Braatz, Richard D.

Article 4

An Air-Lift Crystallizer Can Suppress Secondary Nucleation at a Higher Supersaturation Compared to a Stirred Crystallizer

Crystal Growth and Design, v. 14, (7), July 2014, p. 3264-3275
Lakerveld, Richard; Van Krochten, Jeroen J.H.; Kramer, Herman J.M.

Application of Continuous Crystallization in an Integrated Continuous Pharmaceutical Pilot Plant

Crystal growth & design, v. 14, (5), May 2014, p. 2148-2157
Zhang, Haitao; Lakerveld, Richard; Heider, Patrick L.; Tao, Mengying; Su, Min; Testa, Christopher J.; D'Antonio, Alyssa N.; Barton, Paul I.; Braatz, Richard D.; Trout, Bernhardt L.; Myerson, Allan S.; Jensen, Klavs F.; Evans, James M.B.

Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

Organic Process Research and Development, v. 18, (3), March 2014, p. 402-409
Heider, Patrick L.; Born, Stephen C.; Basak, Soubir; Benyahia, Brahim; Lakerveld, Richard; Zhang, Haitao; Hogan, Rachael; Buchbinder, Louis; Wolfe, Aaron; Mascia, Salvatore; Evans, James M.B.; Jamison, Timothy F.; Jensen, Klavs F.

Integrated design of microwave and photocatalytic reactors. Where are we now?

Current Opinion in Chemical Engineering, v. 5, 2014, p. 37-41
Lakerveld, Richard; Sturm, Gsj S.J.; Stankiewicz, Ai I.; Stefanidis, Georgios D.

Conference paper 2

Microwave Assisted Fines Control during Crystallization

BIWIC 2014 : 21st International workshop on industrial crystallization : September 10-12, 2014, University of Rouen, France, Gérard Coquerel, Yohann Cartigny, Nicolas Couvrat. Mont-Saint-Aignan : Presses universitaires de Rouen et du Havre, 2014, p. 97-104
Kacker, R.; Lakerveld, Richard; Kramer, Herman J.M.

The application of an automated plant-wide control strategy for a continuous pharmaceutical pilot plant

Proceedings of the American Control Conference, 2014, article number 6858854, p. 3512-3517
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick L.; Zhang, Haitao; Wolfe, Aaron; Testa, Christopher J.; Ogden, Sean; Hersey, Devin R.; Mascia, Salvatore; Evans, James M.B.; Braatz, Richard D.; Barton, Paul I.

Article 3

Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant

Processes, v. 1, (3), November 2013, p. 330-348
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick L.; Zhang, Haitao; Braatz, Richard D.; Barton, Paul I.

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

Angewandte Chemie - International Edition, v. 52, (47), November 2013, p. 12359-12363
Mascia, Salvatore; Heider, Patrick L.; Zhang, Haitao; Lakerveld, Richard; Benyahia, Brahim; Barton, Paul I.; Braatz, Richard D.; Cooney, Charles L.; Evans, James M.B.; Jamison, Timothy F.; Jensen, Klavs F.; Myerson, Allan S.; Trout, Bernhardt L.

Model-Based Design of a Plant-Wide Control Strategy for a Continuous Pharmaceutical Plant

AIChE Journal, v. 59, (10), October 2013, p. 3671-3685
Lakerveld, Richard; Benyahia, Brahim; Braatz, Richard D.; Barton, Paul I.

Conference paper 2

Crystallization of L-ascorbic acid in a 18-L airlift crystallizer

Pharmaceutical Discovery, Development and Manufacturing Forum 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, 2013, p. 142-143
Lakerveld, Richard; Van krochten, Jeroen; Anisi, Fatemeh; Stankiewicz, Andrzej; Kramer, Herman

Membrane-assisted Crystallization of L-ascorbic Acid

Lakerveld, Richard; Goddrie, S.F.M.; Anisi, Fatemeh; Stankiewicz, Andrzej I.; Kramer, Herman J.M.

Article 3

A master-equation approach to simulate kinetic traps during directed self-assembly

The Journal of Chemical Physics, v. 136, (18), May 2012, article number 184109
Lakerveld, Richard; Stephanopoulos, George; Barton, Paul I.

A Plant-Wide Dynamic Model of a Continuous Pharmaceutical Process

Industrial & Engineering Chemistry Research, v. 51, (47), November 2012, p. 15393-15412
Benyahia, Brahim; Lakerveld, Richard; Barton, Paul I.

Minimization of Attrition and Breakage in an Airlift Crystallizer

Industrial & Engineering Chemistry Research, v. 51, (33), August 2012, p. 10895-10909
Soare, Anamaria; Lakerveld, Richard; Van Royen, Jurjen; Zocchi, Giorgia; Stankiewicz, Andrzej I.; Kramer, Herman J.M.

Article 1

Application of Ultrasound for Start-Up of Evaporative Batch Crystallization of Ammonium Sulfate in a 75-L Crystallizer

AIChE Journal, v. 57, (12), December 2011, p. 3367-3377
Lakerveld, Richard; Verzijden, Nelleke G.; Kramer, Herman; Jansens, Peter; Grievink, Johan

Conference paper 1

Towards robust fabrication of non-periodic nanoscale systems via directed self assembly

Computer-aided chemical engineering, v. 29, 2011, p. 1603-1607
Lakerveld, Richard; Stephanopoulos, George; Barton, Paul I.

Article 2

Application of generic principles of process intensification to solution crystallization enabled by a task-based design approach

Chemical Engineering and Processing: Process Intensification, v. 49, (9), September 2010, p. 979-991
Lakerveld, Richard; Kramer, Herman J.M.; Stankiewicz, Andrzej I.; Grievink, Johan

Membrane assisted crystallization using reverse osmosis: Influence of solubility characteristics on experimental application and energy saving potential

Chemical Engineering Science, v. 65, (9), May 2010, p. 2689-2699
Lakerveld, Richard; Kuhn, Jelan; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan

Conference paper 1

A Plant-Wide Control Strategy for Continuous Pharmaceutical Manufacturing

AlChE, 10 Nov 2010
Lakerveld, Richard; Braatz, Richard D.; Barton, Paul I.

Article 2

Characterization and Dynamic Optimization of Membrane-Assisted Crystallization of Adipic Acid

Industrial & Engineering Chemistry Research, v. 48, (11), June 2009, p. 5360-5369
Kuhn, Jelan; Lakerveld, Richard; Kramer, Herman J.M.; Grievink, Johan; Jansens, Peter J.

The application of a task-based concept for the design of innovative industrial crystallizers

Computers & Chemical Engineering, v. 33, (10), October 2009, p. 1692-1700, Selected Papers from the 18th European Symposium on Computer Aided Process Engineering (ESCAPE-18)
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan

Conference paper 3

Opportunities for process intensification in crystallization: application of air-mixed devices

EPIC 2009 Conference Proceedings, Venice, Italy, 2009
Lakerveld, R.; Kramer, H.J.M.; Stankiewicz, A.I.; Jansens, P.J.; Grievink, J.

The Application of a Task Based Design Approach to Solution Crystallization

Design for Energy and the Environment: Proceedings of the Seventh International Conference on the Foundations of Computer-Aided Process Design, Breckenridge, Colorado, United States, 2009
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan

The Application of a Task-Based Concept for Design of Innovative Industrial Crystallizers

Computer-aided chemical engineering, v. 27, 2009, p. 909-914
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan

Conference paper 6

A task based design approach for solution crystallization

BIWIC 2008 - 15th International Workshop on Industrial Crystallization, Aachen, Germany, 10-12 September 2008 p. 95-102
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.

A Task Based Design Approach for Solution Crystallization

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 27-34
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.

Membrane Assisted Evaporative Crystallization: Optimization of Task Supersaturation Generation

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 827-834
Lakerveld, R.; Kuhn, J.; Bosch, M.A.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.

Solution Crystallization in a Bubble Column Optimization of the task: Crystal Growth

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 819-826
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.

The Application Of A Task-Based Concept For The Design Of Innovative Industrial Crystallizers

Computer-aided chemical engineering, v. 25, 2008, p. 103-108
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan

The Application of Ultrasound for Seeding Purposes Optimization of the task: Nucleation

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 835-842
Lakerveld, R.; Verzijden, P.G.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.

Conference paper 2

Novel design strategies for solution crystallization processes

AIChE Annual Meeting, Conference Proceedings, 2007
Kramer, Herman J.M.; Lakerveld, Richard; Jansens, Peter J.; Grievink, Johan

The application of different seeding techniques for solution crystallization of ammonium sulphate

BIWIC 2007, 2007, p. 221-228
Lakerveld, Richard; Kalbasenka, A.N.; Kramer, Herman J.M.; Grievink, Johan; Jansens, Peter J.

Conference paper 1

Task based design techniques for solution crystallisation processes: Application to a bubble column setup

BIWIC 2006, 2006, p. 114-121
Lakerveld, Richard; Djatmiko, M.E.; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan

Article 1

Exothermic isomerization reaction in a reactive flash: Steady-state behavior

Industrial & Engineering Chemistry Research, v. 44, (10), May 2005, p. 3815-3822
Lakerveld, Richard; Bildea, Costin Sorin; Almeida-Rivera, Cristhian P.

2018 12

11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons

CrystEngComm, v. 20, (9), March 2018, p. 1205-1219
Nisar, Madiha; Sung, Ho Yung; Puschmann, Horst; Lakerveld, Richard; Haynes, Richard Kingston; Williams, Ian Duncan
Article

A review on recent technologies for the manufacture of pulmonary drugs

Therapeutic Delivery, v. 9, (1), January 2018, p. 47-70
Hadiwinoto, Gabriela Daisy; Lip Kwok, Philip Chi; Lakerveld, Richard
Article

Control system implementation and plant-wide control of continuous pharmaceutical manufacturing pilot plant (end-to-end manufacturing process)

Computer Aided Chemical Engineering: Process Systems Engineering for Pharmaceutical Manufacturing, v. 41, 2018, p. 403-430
Lakerveld, Richard
Article

Design, Characterization and Model Validation of a LED-based Photocatalytic Reactor for Gas Phase Applications

Chemical Engineering Journal, v. 333, February 2018, p. 456-466
Khodadadian, Fatemeh; De boer, Merijn W.; Poursaeidesfahani, Ali; Van ommen, J. Ruud; Stankiewicz, Andrzej I.; Lakerveld, Richard
Article

Electric-Field-Assisted Protein Crystallization in Continuous Flow

Crystal Growth & Design, v. 18, (5), May 2018, p. 2964-2971
Li, Fei; Lakerveld, Richard
Article

Feedback control for defect-free alignment of colloidal particles

Lab on a Chip, v. 18, (14), July 2018, p. 2099-2110
Gao, Yu; Lakerveld, Richard
Article

Process Intensification for Pharmaceutical Crystallization

Chemical Engineering and Processing Process Intensification, v. 127, May 2018, p. 111-126
Wang, Jiayuan; Li, fei; Lakerveld richard
Article

3D Printing for Rapid Prototyping of Innovative Process Equipment for Pharmaceutical Crystallization

Mathew Thomas, Kiran; Ik shin, Dong; Lakerveld, Richard
Conference paper

Batch Crystallization of Rifapentine for Inhalable Tuberculosis Medication

AIP Conference Proceedings, v. 1933, February 2018, article number 030023
Wijanarko, Anondho; Meivita, Maria Prisca; Hermansyah, Heri; Sahlan, Muhamad; Lakerveld, Richard
Conference paper

Experimental validation of scheduled PID control for directed self-assembly of colloidal particles in microfluidic devices

Computer Aided Chemical Engineering, v. 44, 2018, p. 2455-2460
Gao, Yu; Lakerveld, Richard
Conference paper

Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling

Computer Aided Chemical Engineering, v. 44, July 2018, p. 1051-1056
Wang, Jiayuan; Lakerveld, Richard
Conference paper

Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling

Wang, Jiayuan; Lakerveld, Richard
Conference paper

2017 8

An Optimization-based Approach for Structural Design of Self-assembled DNA Tiles

AIChE Journal, 63, 6, June 2017, p. 1804-1817
Gao, Yu; Mi, Yongli; Lakerveld, Richard
Article

Continuous Membrane-Assisted Crystallization To Increase the Attainable Product Quality of Pharmaceuticals and Design Space for Operation

Industrial & Engineering Chemistry Research, v. 56, (19), May 2017, p. 5705-5714
Wang, Jiayuan; Lakerveld, Richard
Article

Influence of Alternating Electric Fields on Protein Crystallization in Microfluidic Devices with Patterned Electrodes in a Parallel-Plate Configuration

Crystal Growth and Design, v. 17, (6), June 2017, p. 3062-3070
Li, Fei; Lakerveld, Richard
Article

Model Predictive Control of an Integrated Continuous Pharmaceutical Manufacturing Pilot Plant

Organic Process Research & Development, v. 21, (6), June 2017, p. 844-854
Mesbah, Ali; Paulson, Joel.A.; Lakerveld, Richard; Braatz, Richard D.
Article

End to End Continuous Manufacturing: Integration of Unit Operations

Continuous Manufacturing of Pharmaceuticals / Peter Kleinebudde, Johannes Khinast, and Jukka Rantanen. John Wiley & Sons Ltd, 2017, p. 447-483
Lakerveld, Richard; Heider, P.L.; Jensen, K.D.; Braatz, R.D.; Jensen, K.F.; Myerson, A.S.; Trout, B.L.
Book chapter

Continuous crystallization of an active pharmaceutical ingredient for pulmonary drug delivery

Hadiwinoto, gabriela d.; Kwok, philip c.l.; Tong, henry h.y.; Lakerveld, Richard
Conference paper

Electric-field-assisted protein crystallization in microfluidic devices with patterned electrodes in a parallel-plate configuration

Li, Fei; Lakerveld, Richard
Conference paper

Integrated Solvent and Process Design Using PC-SAFT for Continuous Anti-Solvent Crystallization Including Solvent Recycling

Wang, Jiayuan; Lakerveld, Richard
Conference paper

2016 4

Microwave Assisted Direct Nucleation Control for Batch Crystallization: Crystal Size Control with Reduced Batch Time

Crystal Growth and Design, v. 16, (1), January 2016, p. 440-446
Kacker, Rohit; Salvador, Pedro M.; Sturm, Guidso S. J.; Stefanidis, Georgios D.; Lakerveld, Richard; Nagy, Zoltan K.; Kramer, Herman J. M.
Article

Model-Based Optimization of a Photocatalytic Reactor with Light-Emitting Diodes

Chemical Engineering and Technology, v. 39, (10), October 2016, p. 1946-1954
Khodadadian, Fatemeh; Poursaeidesfahani, Ali; Li, Zonghan; van Ommen, J. Ruud; Stankiewicz, Andrzej I.; Lakerveld, Richard
Article

Photocatalysis: Past Achievements and Future Trends

Alternative Energy Sources for Green Chemistry / Edited by Georgios Stefanidis, Andrzej Stankiewicz. Cambridge, UK : The Royal Society of Chemistry, 2016, p. 227-269, Ch. 8, Book series: Green Chemistry, v. 47
Khodadadian, Fatemeh; Nasalevich, Maxim; Kapteijn, Freek; Stankiewicz, Andrzej I.; Lakerveld, Richard; Gascon, Jorge
Book chapter

Modelling and Experimental Validation of An Annular LED-based Photocatalytic Reactor

22nd International Congress of Chemical and Process Engineering, CHISA 2016 and 19th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, PRES 2016, v. 1, 2016, p. 39-40
Khodadadian, Fatemeh; De Boer, Merijn W.; Van Ommen, J. Ruud; Stankiewicz, Andrzej; Lakerveld, Richard
Conference paper

2015 5

Controlled formation of nanostructures with desired geometries: Part 3. Dynamic modeling and simulation of directed self-assembly of nanoparticles through adaptive finite state projection

Industrial and Engineering Chemistry Research, v. 54, (16), April 2015, p. 4371-4384
Ramaswamy, Sivaraman; Lakerveld, Richard; Barton, Paul I.; Stephanopoulos, George
Article

The Application of an Automated Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant

Organic process research & development, v. 19, (9), 2015, p. 1088-1100
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick l.; Zhang, Haitao; Wolfe, Aaron; Testa, Christopher j.; Ogden, Sean; Hersey, Devin r.; Mascia, Salvatore; Evans, James M.B.; Braatz, Richard D.; Barton, Paul I.
Article

Model-based Optimization of a LED-based Photocatalytic Reactor

Catalysis and Reaction Engineering Division 2015: Core Programming Area at the 2015 AIChE Annual Meeting, American Institute of Chemical Engineers (AIChE), 2015, p. 470-472
Khodadadian, Fatemeh; Li, Zonghan; Van ommen, Ruud; Stankiewicz, Andrzej; Lakerveld, Richard
Conference paper

Model-based Optimization of LED-based photocatalytic reactors

Khodadadian, Fatemeh; Li, Zonghan; Stankiewicz, Andrzej; Lakerveld, Richard
Conference paper

Plant-wide Model Predictive Control for a Continuous Pharmaceutical Process

2015 American Control Conference (ACC 2015) /IEEE. New York, USA : Institute of Electrical and Electronics Engineers (IEEE), 2015, p. 4301-4307
Mesbah, Ali; Paulson, Joel A.; Lakerveld, Richard; Braatz, Richard D.
Conference paper

2014 6

An Air-Lift Crystallizer Can Suppress Secondary Nucleation at a Higher Supersaturation Compared to a Stirred Crystallizer

Crystal Growth and Design, v. 14, (7), July 2014, p. 3264-3275
Lakerveld, Richard; Van Krochten, Jeroen J.H.; Kramer, Herman J.M.
Article

Application of Continuous Crystallization in an Integrated Continuous Pharmaceutical Pilot Plant

Crystal growth & design, v. 14, (5), May 2014, p. 2148-2157
Zhang, Haitao; Lakerveld, Richard; Heider, Patrick L.; Tao, Mengying; Su, Min; Testa, Christopher J.; D'Antonio, Alyssa N.; Barton, Paul I.; Braatz, Richard D.; Trout, Bernhardt L.; Myerson, Allan S.; Jensen, Klavs F.; Evans, James M.B.
Article

Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

Organic Process Research and Development, v. 18, (3), March 2014, p. 402-409
Heider, Patrick L.; Born, Stephen C.; Basak, Soubir; Benyahia, Brahim; Lakerveld, Richard; Zhang, Haitao; Hogan, Rachael; Buchbinder, Louis; Wolfe, Aaron; Mascia, Salvatore; Evans, James M.B.; Jamison, Timothy F.; Jensen, Klavs F.
Article

Integrated design of microwave and photocatalytic reactors. Where are we now?

Current Opinion in Chemical Engineering, v. 5, 2014, p. 37-41
Lakerveld, Richard; Sturm, Gsj S.J.; Stankiewicz, Ai I.; Stefanidis, Georgios D.
Article

Microwave Assisted Fines Control during Crystallization

BIWIC 2014 : 21st International workshop on industrial crystallization : September 10-12, 2014, University of Rouen, France, Gérard Coquerel, Yohann Cartigny, Nicolas Couvrat. Mont-Saint-Aignan : Presses universitaires de Rouen et du Havre, 2014, p. 97-104
Kacker, R.; Lakerveld, Richard; Kramer, Herman J.M.
Conference paper

The application of an automated plant-wide control strategy for a continuous pharmaceutical pilot plant

Proceedings of the American Control Conference, 2014, article number 6858854, p. 3512-3517
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick L.; Zhang, Haitao; Wolfe, Aaron; Testa, Christopher J.; Ogden, Sean; Hersey, Devin R.; Mascia, Salvatore; Evans, James M.B.; Braatz, Richard D.; Barton, Paul I.
Conference paper

2013 5

Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant

Processes, v. 1, (3), November 2013, p. 330-348
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick L.; Zhang, Haitao; Braatz, Richard D.; Barton, Paul I.
Article

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

Angewandte Chemie - International Edition, v. 52, (47), November 2013, p. 12359-12363
Mascia, Salvatore; Heider, Patrick L.; Zhang, Haitao; Lakerveld, Richard; Benyahia, Brahim; Barton, Paul I.; Braatz, Richard D.; Cooney, Charles L.; Evans, James M.B.; Jamison, Timothy F.; Jensen, Klavs F.; Myerson, Allan S.; Trout, Bernhardt L.
Article

Model-Based Design of a Plant-Wide Control Strategy for a Continuous Pharmaceutical Plant

AIChE Journal, v. 59, (10), October 2013, p. 3671-3685
Lakerveld, Richard; Benyahia, Brahim; Braatz, Richard D.; Barton, Paul I.
Article

Crystallization of L-ascorbic acid in a 18-L airlift crystallizer

Pharmaceutical Discovery, Development and Manufacturing Forum 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, 2013, p. 142-143
Lakerveld, Richard; Van krochten, Jeroen; Anisi, Fatemeh; Stankiewicz, Andrzej; Kramer, Herman
Conference paper

Membrane-assisted Crystallization of L-ascorbic Acid

Lakerveld, Richard; Goddrie, S.F.M.; Anisi, Fatemeh; Stankiewicz, Andrzej I.; Kramer, Herman J.M.
Conference paper

2012 3

A master-equation approach to simulate kinetic traps during directed self-assembly

The Journal of Chemical Physics, v. 136, (18), May 2012, article number 184109
Lakerveld, Richard; Stephanopoulos, George; Barton, Paul I.
Article

A Plant-Wide Dynamic Model of a Continuous Pharmaceutical Process

Industrial & Engineering Chemistry Research, v. 51, (47), November 2012, p. 15393-15412
Benyahia, Brahim; Lakerveld, Richard; Barton, Paul I.
Article

Minimization of Attrition and Breakage in an Airlift Crystallizer

Industrial & Engineering Chemistry Research, v. 51, (33), August 2012, p. 10895-10909
Soare, Anamaria; Lakerveld, Richard; Van Royen, Jurjen; Zocchi, Giorgia; Stankiewicz, Andrzej I.; Kramer, Herman J.M.
Article

2011 2

Application of Ultrasound for Start-Up of Evaporative Batch Crystallization of Ammonium Sulfate in a 75-L Crystallizer

AIChE Journal, v. 57, (12), December 2011, p. 3367-3377
Lakerveld, Richard; Verzijden, Nelleke G.; Kramer, Herman; Jansens, Peter; Grievink, Johan
Article

Towards robust fabrication of non-periodic nanoscale systems via directed self assembly

Computer-aided chemical engineering, v. 29, 2011, p. 1603-1607
Lakerveld, Richard; Stephanopoulos, George; Barton, Paul I.
Conference paper

2010 3

Application of generic principles of process intensification to solution crystallization enabled by a task-based design approach

Chemical Engineering and Processing: Process Intensification, v. 49, (9), September 2010, p. 979-991
Lakerveld, Richard; Kramer, Herman J.M.; Stankiewicz, Andrzej I.; Grievink, Johan
Article

Membrane assisted crystallization using reverse osmosis: Influence of solubility characteristics on experimental application and energy saving potential

Chemical Engineering Science, v. 65, (9), May 2010, p. 2689-2699
Lakerveld, Richard; Kuhn, Jelan; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Article

A Plant-Wide Control Strategy for Continuous Pharmaceutical Manufacturing

AlChE, 10 Nov 2010
Lakerveld, Richard; Braatz, Richard D.; Barton, Paul I.
Conference paper

2009 5

Characterization and Dynamic Optimization of Membrane-Assisted Crystallization of Adipic Acid

Industrial & Engineering Chemistry Research, v. 48, (11), June 2009, p. 5360-5369
Kuhn, Jelan; Lakerveld, Richard; Kramer, Herman J.M.; Grievink, Johan; Jansens, Peter J.
Article

The application of a task-based concept for the design of innovative industrial crystallizers

Computers & Chemical Engineering, v. 33, (10), October 2009, p. 1692-1700, Selected Papers from the 18th European Symposium on Computer Aided Process Engineering (ESCAPE-18)
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Article

Opportunities for process intensification in crystallization: application of air-mixed devices

EPIC 2009 Conference Proceedings, Venice, Italy, 2009
Lakerveld, R.; Kramer, H.J.M.; Stankiewicz, A.I.; Jansens, P.J.; Grievink, J.
Conference paper

The Application of a Task Based Design Approach to Solution Crystallization

Design for Energy and the Environment: Proceedings of the Seventh International Conference on the Foundations of Computer-Aided Process Design, Breckenridge, Colorado, United States, 2009
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Conference paper

The Application of a Task-Based Concept for Design of Innovative Industrial Crystallizers

Computer-aided chemical engineering, v. 27, 2009, p. 909-914
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Conference paper

2008 6

A task based design approach for solution crystallization

BIWIC 2008 - 15th International Workshop on Industrial Crystallization, Aachen, Germany, 10-12 September 2008 p. 95-102
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

A Task Based Design Approach for Solution Crystallization

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 27-34
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

Membrane Assisted Evaporative Crystallization: Optimization of Task Supersaturation Generation

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 827-834
Lakerveld, R.; Kuhn, J.; Bosch, M.A.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

Solution Crystallization in a Bubble Column Optimization of the task: Crystal Growth

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 819-826
Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

The Application Of A Task-Based Concept For The Design Of Innovative Industrial Crystallizers

Computer-aided chemical engineering, v. 25, 2008, p. 103-108
Lakerveld, Richard; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Conference paper

The Application of Ultrasound for Seeding Purposes Optimization of the task: Nucleation

17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, the Netherlands, 2008, p. 835-842
Lakerveld, R.; Verzijden, P.G.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J.
Conference paper

2007 2

Novel design strategies for solution crystallization processes

AIChE Annual Meeting, Conference Proceedings, 2007
Kramer, Herman J.M.; Lakerveld, Richard; Jansens, Peter J.; Grievink, Johan
Conference paper

The application of different seeding techniques for solution crystallization of ammonium sulphate

BIWIC 2007, 2007, p. 221-228
Lakerveld, Richard; Kalbasenka, A.N.; Kramer, Herman J.M.; Grievink, Johan; Jansens, Peter J.
Conference paper

2006 1

Task based design techniques for solution crystallisation processes: Application to a bubble column setup

BIWIC 2006, 2006, p. 114-121
Lakerveld, Richard; Djatmiko, M.E.; Kramer, Herman J.M.; Jansens, Peter J.; Grievink, Johan
Conference paper

2005 1

Exothermic isomerization reaction in a reactive flash: Steady-state behavior

Industrial & Engineering Chemistry Research, v. 44, (10), May 2005, p. 3815-3822
Lakerveld, Richard; Bildea, Costin Sorin; Almeida-Rivera, Cristhian P.
Article

Teaching Assignment

2024-25 Fall 6 2023-24 Summer 3 2023-24 Spring 6 2023-24 Winter 0 2023-24 Fall 9 2022-23 Summer 0

BIEN4920	Bioengineering Capstone Design
BIEN4930	Bioengineering Thesis Research
CENG2110	Process and Product Design Principles
CENG4920	Chemical Engineering Capstone Design
CENG4930	Chemical Engineering Thesis Research
ENEG4920	Final Year Design Project

BIEN4930	Bioengineering Thesis Research
BIEN4990	Academic and Professional Development II
UROP1000	Undergraduate Research Opportunities

BEHI5008	Pharmaceutical Engineering
BIEN4920	Bioengineering Capstone Design
BIEN4930	Bioengineering Thesis Research
CENG3150	Integrated Chemical Process and Product Design
CENG4920	Chemical Engineering Capstone Design
ENEG4920	Final Year Design Project

BIEN2990	Academic and Professional Development I
BIEN4920	Bioengineering Capstone Design
BIEN4930	Bioengineering Thesis Research
BIEN4990	Academic and Professional Development II
CENG1010	Academic and Professional Development I
CENG4020	Academic and Professional Development II
CENG4670	Pharmaceutical Engineering
CENG4920	Chemical Engineering Capstone Design
ENEG4920	Final Year Design Project

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

WANG, Yunlong
Chemical and Biomolecular Engineering
LI, Jiatao
Chemical and Biomolecular Engineering

Master of Philosophy

OVERGAARD, Rasmus
Chemical and Biomolecular Engineering

Graduated RPGs

Doctor of Philosophy

GUPTA, Dishika
Chemical and Biomolecular Engineering( Completed in 2024 )
LO, Po Sang
Chemical and Biomolecular Engineering( Completed in 2024 )
MENDIS, Nethrue Pramuditha
Chemical and Biomolecular Engineering( Completed in 2023 )
XU, Xiaojin
Chemical and Biomolecular Engineering( Completed in 2023 )
YEOH, Keat Ping (co-supervision)
Chemical and Biomolecular Engineering( Completed in 2023 )
KWON, Soo Jin
Chemical and Biomolecular Engineering( Completed in 2022 )
NYANDE, Baggie Waponde
Chemical and Biomolecular Engineering( Completed in 2022 )
CHEN, Ruipeng
Chemical and Biomolecular Engineering( Completed in 2021 )
MATHEW THOMAS, Kiran
Chemical and Biomolecular Engineering( Completed in 2021 )

Master of Philosophy

HO, Cheuk Hei
Chemical and Biomolecular Engineering( Completed in 2021 )

Projects

From January 2022 to December 2024

All Projects 4 Leading Projects 3 Participating Projects 1

A Proof of Concept for the Electric-field-assisted Crystallization of a Monoclonal Antibody for Industrial Purification

用於工業純化的電場輔助結晶單克隆抗體的概念性驗證 Leading

Innovation and Technology Fund
Project Team (HKUST)
LAKERVELD Richard (Lead)

SUN Fei
2023 -
Toward the optimal model-based design of multi-component pharmaceutical crystals with enhanced solubility for improved oral delivery of drugs with low aqueous solubility

研究具有提高溶解度的多組分藥物晶體的最優模型設計以改善低水溶性藥物的口服效果 Leading

RGC - General Research Fund
Project Team (HKUST)
LAKERVELD Richard (Lead)
2022 -
Large-Scale Screening of Infected Individuals by Fragment Length Identification of Pooled Nucleic Acid Samples (FLIPNAS)

利用片段長度標記的集合核酸檢測法對大規模樣本中感染個體的篩查與鑒定的研究 Participating

Innovation and Technology Fund, Raymond Industrial Ltd., Shenzhen Uni-medica Technology Co., Ltd.
Project Team (HKUST)
HSING I-ming (Lead)

LAKERVELD Richard

YAO Shuhuai
2021 - 2024
A novel combined crystallization and membrane emulsification process for the manufacture of pharmaceutical crystals of uniform and controllable size

一種新型的用於製造均勻和可控尺寸的藥物晶體的結晶和膜乳化相結合的過程 Leading

RGC - General Research Fund
Project Team (HKUST)
LAKERVELD Richard (Lead)
2019 - 2023