Faculty Profiles - ZHANG Lisheng | The Hong Kong University of Science and Technology

Lisheng ZHANG
張理升

PhD in Chemistry
The University of Chicago, 2019

Assistant Professor
Division of Life Science
Department of Chemistry

(852) 3469 2392
zhangls@ust.hk
Room 5521
Personal Web

Google Scholar

YMZv4UAAAAAJ

ORCID

0000-0003-1872-9978

ResearcherID

GLM-5059-2022

Scopus ID

56514199600

Research Interest Publications Teaching Assignment RPG Supervision

Research Interest

Epigenetics
Chemical biology
Immunology
Cancer
Computational biology

Publications

All Years 22 2023 4 2022 4 2021 4 2020 2 2019 2 2018 0 2017 6

2023 4

BID-seq: The Quantitative and Base-Resolution Sequencing Method for RNA Pseudouridine

ACS Chemical Biology, v. 18, (1), January 2023, p. 4-6
Zhang, Lisheng; Dai, Qing; He, Chuan
Article

Exon architecture controls mRNA m⁶A modification and gene expression

Science, v. 379, (6633), January 2023, p. 677-682
He, P. Cody; Wei, Jiangbo; Dou, Xiaoyang; Harada, Bryan T.; Zhang, Zijie; Ge, Ruiqi; Liu, Chang; Zhang, Lisheng; Yu, Xianbin; Wang, Shuai; Lyu, Ruitu; Zou, Zhongyu; Chen, Mengjie; He, Chuan
Article

Quantitative sequencing uncovers abundant pseudouridines in mammalian mRNA at base resolution

Nature Biotechnology, v. 41, March 2023, p. 344-354
Dai, Qing; Zhang, Lisheng; Sun, Hui-Lung; Pajdzik, Kinga; Yang, Lei; Ye, Chang; Ju, Cheng-Wei; Liu, Shun; Wang, Yuru; Zheng, Zhong; Zhang, Linda; Harada, Bryan T.; Dou, Xiaoyang; Irkliyenko, Iryna; Feng, Xinran; Zhang, Wen; Pan, Tao; He, Chuan
Article

Quantitative base-resolution sequencing technology for mapping pseudouridines in mammalian mRNA

Methods in Enzymology / Cambridge, Massachusetts : Elsevier, 2023
Zhang, Lisheng; Dai, Qing; He, Chuan
Book chapter

2022 4

5-methylcytosine (m⁵C) RNA modification controls the innate immune response to virus infection by regulating type I interferons

Proceedings of the National Academy of Sciences of the United States of America, v. 119, (42), October 2022, article number e2123338119
Zhang, Yuexiu; Zhang, Lisheng; Dai, Qing; Chen, Phylip; Lu, Mijia; Kairis, Elizabeth L.; Murugaiah, Valarmathy; Xu, Jiayu; Shukla, Rajni Kant; Liang, Xueya; Zou, Zhongyu; Cormet-Boyaka, Estelle; Qiu, Jianming; Peeples, Mark E.; Sharma, Amit; He, Chuan; Li, Jianrong
Article

FTO mediates LINE1 m⁶A demethylation and chromatin regulation in mESCs and mouse development

Science, v. 376, (6596), May 2022, article number eabe9582, p. 968-973
Wei, Jiangbo; Zhang, Lisheng; Gao, Shaorong; Gao, Yawei; He, Chuan
Article

m⁶A RNA modifications are measured at single-base resolution across the mammalian transcriptome

Nature Biotechnology, v. 40, (8), August 2022, p. 1210-1219
Hu, Lulu; Liu, Shun; Peng, Yong; Ge, Ruiqi; Su, Rui; Senevirathne, Chamara; Harada, Bryan T.; Dai, Qing; Wei, Jiangbo; Zhang, Lisheng; Hao, Ziyang; Luo, Liangzhi; Wang, Huanyu; Wang, Yuru; Luo, Minkui; Chen, Mengjie; Chen, Jianjun; He, Chuan
Article

m⁷G-quant-seq: Quantitative Detection of RNA Internal N⁷-Methylguanosine

ACS Chemical Biology, v. 17, (12), December 2022, p. 3306-3312
Zhang, Lisheng; Ju, Cheng-Wei; Liu, Chang; Wei, Jiangbo; Dai, Qing; Chen, Li; Ye, Chang; He, Chuan
Article

2021 4

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Molecular Cell, v. 81, (20), 21 October 2021, p. 4228-4242
Tsao, Ning; Brickner, Joshua R.; Rodell, Rebecca; Ganguly, Adit; Wood, Matthew; Oyeniran, Clement; Ahmad, Tanveer; Sun, Hua; Bacolla, Albino; Zhang, Lisheng; Lukinović, Valentina; Soll, Jennifer M.; Townley, Brittany A.; Casanova, Alexandre G.; Tainer, John A.; He, Chuan; Vindigni, Alessandro; Reynoird, Nicolas; Mosammaparast, Nima
Article

ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing

Nature Cell Biology, v. 23, (7), July 2021, p. 684-691
Zhang, Lisheng; Xiong, Qing-Ping; Peña Perez, Sonia; Liu, Chang; Wei, Jiangbo; Le, Cassy; Zhang, Linda; Harada, Bryan T.; Dai, Qing; Feng, Xinran; Hao, Ziyang; Wang, Yuru; Dong, Xueyang; Hu, Lulu; Wang, En-Duo; Pan, Tao; Klungland, Arne; Liu, Ru-Juan; He, Chuan
Article

LEAD-m⁶A-seq for Locus-Specific Detection of N⁶-Methyladenosine and Quantification of Differential Methylation

Angewandte Chemie - International Edition, v. 60, (2), January 2021, p. 873-880
Wang, Yuru; Zhang, Zijie; Sepich-Poore, Caraline; Zhang, Lisheng; Xiao, Yu; He, Chuan
Article

Transcriptome-Wide Detection of Internal N⁷-Methylguanosine

Methods in Molecular Biology, v. 2298 / edited by Mary McMahon. New York, NY : Humana, 2021, p. 97-104
Zhang, Lisheng; Liu, Chang; He, Chuan
Book chapter

2020 2

DNA 5-Methylcytosine-Specific Amplification and Sequencing

Journal of the American Chemical Society, v. 142, (10), March 2020, p. 4539-4543
Liu, Chang; Cui, Xiaolong; Zhao, Boxuan Simen; Narkhede, Pradnya; Gao, Yawei; Liu, Jun; Dou, Xiaoyang; Dai, Qing; Zhang, Lisheng; He, Chuan
Article

N⁶-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA

Molecular Cell, v. 78, (3), May 2020, p. 382-395
Hao, Ziyang; Wu, Tong; Cui, Xiaolong; Zhu, Pingping; Tan, Caiping; Dou, Xiaoyang; Hsu, Kai-Wen; Lin, Yueh-Te; Peng, Pei-Hua; Zhang, Lisheng; Gao, Yiwei; Hu, Lulu; Sun, Hui-Lung; Zhu, Allen; Liu, Jianzhao; Wu, Kou-Juey; He, Chuan
Article

2019 2

Transcriptome-wide Mapping of Internal N⁷-Methylguanosine Methylome in Mammalian mRNA

Molecular Cell, v. 74, (6), 20 June 2019, p. 1304-1316
Zhang, Lisheng; Liu, Chang; Ma, Honghui; Dai, Qing; Sun, Hui-Lung; Luo, Guanzheng; Zhang, Zijie; Zhang, Linda; Hu, Lulu; Dong, Xueyang; He, Chuan
Article

tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance

Cell Systems, v. 8, (4), 24 April 2019, p. 302-314
Masuda, Isao; Matsubara, Ryuma; Christian, Thomas; Rojas, Enrique R.; Yadavalli, Srujana S.; Zhang, Lisheng; Goulian, Mark; Foster, Leonard J.; Huang, Kerwyn Casey; Hou, Ya-Ming
Article

2016 2

Direct Oxidation of Aliphatic C–H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Organic Letters, v. 18, (6), March 2016, p. 1234-1237
Li, Xin; Che, Xing; Chen, Gui-Hua; Zhang, Jun; Yan, Jia-Lei; Zhang, Yun-Fei; Zhang, Lisheng; Hsu, Chao-Ping; Gao, Yi Qin; Shi, Zhang-Jie
Article

Nickel- or iron- catalyzed cross-coupling of aryl carbamates with arylsilanes

Advanced Synthesis and Catalysis, v. 358, (15), July 2016, p. 2410-2416
Shi, Wen-Juan; Zhao, Hong-Wei; Wang, Yang; Cao, Zhi-Chao; Zhang, Lisheng; Yu, Da-Gang; Shi, Zhang-Jie
Article

2014 1

Direct borylation of primary C–H bonds in functionalized molecules by palladium catalysis

Angewandte Chemie - International Edition, v. 53, (15), April 2014, p. 3899-3903
Zhang, Lisheng; Chen, Guihua; Wang, Xin; Guo, Qing-Yun; Zhang, Xi-Sha; Pan, Fei; Chen, Kang; Shi, Zhang-Jie
Article

2013 2

Direct arylation of primary and secondary sp³ C–H bonds with diarylhyperiodonium salts via Pd catalysis

Organic Letters, v. 15, (18), September 2013, p. 4758-4761
Pan, Fei; Shen, Peng-Xiang; Zhang, Lisheng; Wang, Xin; Shi, Zhang-Jie
Article

Palladium-catalyzed trifluoromethylation of aromatic C–H bond directed by an acetamino group

Organic Letters, v. 15, (1), January 2013, p. 10-13
Zhang, Lisheng; Chen, Kang; Chen, Guihua; Li, Bi-Jie; Luo, Shuang; Guo, Qing-Yun; Wei, Jiangbo; Shi, Zhang-Jie
Article

2012 1

Reductive Cleavage of the C_sp2–C_sp3 Bond of Secondary Benzyl Alcohols: Rhodium Catalysis Directed by N-Containing Groups

Angewandte Chemie - International Edition, v. 51, (39), September 2012, p. 9851-9855
Chen, Kang; Li, Hu; Lei, Zhi-Quan; Ye, Wen-He; Zhang, Lisheng; Sun, Jian; Shi, Zhang-Jie
Article

Article 3

BID-seq: The Quantitative and Base-Resolution Sequencing Method for RNA Pseudouridine

ACS Chemical Biology, v. 18, (1), January 2023, p. 4-6
Zhang, Lisheng; Dai, Qing; He, Chuan

Exon architecture controls mRNA m⁶A modification and gene expression

Science, v. 379, (6633), January 2023, p. 677-682
He, P. Cody; Wei, Jiangbo; Dou, Xiaoyang; Harada, Bryan T.; Zhang, Zijie; Ge, Ruiqi; Liu, Chang; Zhang, Lisheng; Yu, Xianbin; Wang, Shuai; Lyu, Ruitu; Zou, Zhongyu; Chen, Mengjie; He, Chuan

Quantitative sequencing uncovers abundant pseudouridines in mammalian mRNA at base resolution

Nature Biotechnology, v. 41, March 2023, p. 344-354
Dai, Qing; Zhang, Lisheng; Sun, Hui-Lung; Pajdzik, Kinga; Yang, Lei; Ye, Chang; Ju, Cheng-Wei; Liu, Shun; Wang, Yuru; Zheng, Zhong; Zhang, Linda; Harada, Bryan T.; Dou, Xiaoyang; Irkliyenko, Iryna; Feng, Xinran; Zhang, Wen; Pan, Tao; He, Chuan

Book chapter 1

Quantitative base-resolution sequencing technology for mapping pseudouridines in mammalian mRNA

Methods in Enzymology / Cambridge, Massachusetts : Elsevier, 2023
Zhang, Lisheng; Dai, Qing; He, Chuan

Article 4

5-methylcytosine (m⁵C) RNA modification controls the innate immune response to virus infection by regulating type I interferons

Proceedings of the National Academy of Sciences of the United States of America, v. 119, (42), October 2022, article number e2123338119
Zhang, Yuexiu; Zhang, Lisheng; Dai, Qing; Chen, Phylip; Lu, Mijia; Kairis, Elizabeth L.; Murugaiah, Valarmathy; Xu, Jiayu; Shukla, Rajni Kant; Liang, Xueya; Zou, Zhongyu; Cormet-Boyaka, Estelle; Qiu, Jianming; Peeples, Mark E.; Sharma, Amit; He, Chuan; Li, Jianrong

FTO mediates LINE1 m⁶A demethylation and chromatin regulation in mESCs and mouse development

Science, v. 376, (6596), May 2022, article number eabe9582, p. 968-973
Wei, Jiangbo; Zhang, Lisheng; Gao, Shaorong; Gao, Yawei; He, Chuan

m⁶A RNA modifications are measured at single-base resolution across the mammalian transcriptome

Nature Biotechnology, v. 40, (8), August 2022, p. 1210-1219
Hu, Lulu; Liu, Shun; Peng, Yong; Ge, Ruiqi; Su, Rui; Senevirathne, Chamara; Harada, Bryan T.; Dai, Qing; Wei, Jiangbo; Zhang, Lisheng; Hao, Ziyang; Luo, Liangzhi; Wang, Huanyu; Wang, Yuru; Luo, Minkui; Chen, Mengjie; Chen, Jianjun; He, Chuan

m⁷G-quant-seq: Quantitative Detection of RNA Internal N⁷-Methylguanosine

ACS Chemical Biology, v. 17, (12), December 2022, p. 3306-3312
Zhang, Lisheng; Ju, Cheng-Wei; Liu, Chang; Wei, Jiangbo; Dai, Qing; Chen, Li; Ye, Chang; He, Chuan

Article 3

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Molecular Cell, v. 81, (20), 21 October 2021, p. 4228-4242
Tsao, Ning; Brickner, Joshua R.; Rodell, Rebecca; Ganguly, Adit; Wood, Matthew; Oyeniran, Clement; Ahmad, Tanveer; Sun, Hua; Bacolla, Albino; Zhang, Lisheng; Lukinović, Valentina; Soll, Jennifer M.; Townley, Brittany A.; Casanova, Alexandre G.; Tainer, John A.; He, Chuan; Vindigni, Alessandro; Reynoird, Nicolas; Mosammaparast, Nima

ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing

Nature Cell Biology, v. 23, (7), July 2021, p. 684-691
Zhang, Lisheng; Xiong, Qing-Ping; Peña Perez, Sonia; Liu, Chang; Wei, Jiangbo; Le, Cassy; Zhang, Linda; Harada, Bryan T.; Dai, Qing; Feng, Xinran; Hao, Ziyang; Wang, Yuru; Dong, Xueyang; Hu, Lulu; Wang, En-Duo; Pan, Tao; Klungland, Arne; Liu, Ru-Juan; He, Chuan

LEAD-m⁶A-seq for Locus-Specific Detection of N⁶-Methyladenosine and Quantification of Differential Methylation

Angewandte Chemie - International Edition, v. 60, (2), January 2021, p. 873-880
Wang, Yuru; Zhang, Zijie; Sepich-Poore, Caraline; Zhang, Lisheng; Xiao, Yu; He, Chuan

Book chapter 1

Transcriptome-Wide Detection of Internal N⁷-Methylguanosine

Methods in Molecular Biology, v. 2298 / edited by Mary McMahon. New York, NY : Humana, 2021, p. 97-104
Zhang, Lisheng; Liu, Chang; He, Chuan

Article 2

DNA 5-Methylcytosine-Specific Amplification and Sequencing

Journal of the American Chemical Society, v. 142, (10), March 2020, p. 4539-4543
Liu, Chang; Cui, Xiaolong; Zhao, Boxuan Simen; Narkhede, Pradnya; Gao, Yawei; Liu, Jun; Dou, Xiaoyang; Dai, Qing; Zhang, Lisheng; He, Chuan

N⁶-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA

Molecular Cell, v. 78, (3), May 2020, p. 382-395
Hao, Ziyang; Wu, Tong; Cui, Xiaolong; Zhu, Pingping; Tan, Caiping; Dou, Xiaoyang; Hsu, Kai-Wen; Lin, Yueh-Te; Peng, Pei-Hua; Zhang, Lisheng; Gao, Yiwei; Hu, Lulu; Sun, Hui-Lung; Zhu, Allen; Liu, Jianzhao; Wu, Kou-Juey; He, Chuan

Article 2

Transcriptome-wide Mapping of Internal N⁷-Methylguanosine Methylome in Mammalian mRNA

Molecular Cell, v. 74, (6), 20 June 2019, p. 1304-1316
Zhang, Lisheng; Liu, Chang; Ma, Honghui; Dai, Qing; Sun, Hui-Lung; Luo, Guanzheng; Zhang, Zijie; Zhang, Linda; Hu, Lulu; Dong, Xueyang; He, Chuan

tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance

Cell Systems, v. 8, (4), 24 April 2019, p. 302-314
Masuda, Isao; Matsubara, Ryuma; Christian, Thomas; Rojas, Enrique R.; Yadavalli, Srujana S.; Zhang, Lisheng; Goulian, Mark; Foster, Leonard J.; Huang, Kerwyn Casey; Hou, Ya-Ming

Article 2

Direct Oxidation of Aliphatic C–H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Organic Letters, v. 18, (6), March 2016, p. 1234-1237
Li, Xin; Che, Xing; Chen, Gui-Hua; Zhang, Jun; Yan, Jia-Lei; Zhang, Yun-Fei; Zhang, Lisheng; Hsu, Chao-Ping; Gao, Yi Qin; Shi, Zhang-Jie

Nickel- or iron- catalyzed cross-coupling of aryl carbamates with arylsilanes

Advanced Synthesis and Catalysis, v. 358, (15), July 2016, p. 2410-2416
Shi, Wen-Juan; Zhao, Hong-Wei; Wang, Yang; Cao, Zhi-Chao; Zhang, Lisheng; Yu, Da-Gang; Shi, Zhang-Jie

Article 1

Direct borylation of primary C–H bonds in functionalized molecules by palladium catalysis

Angewandte Chemie - International Edition, v. 53, (15), April 2014, p. 3899-3903
Zhang, Lisheng; Chen, Guihua; Wang, Xin; Guo, Qing-Yun; Zhang, Xi-Sha; Pan, Fei; Chen, Kang; Shi, Zhang-Jie

Article 2

Direct arylation of primary and secondary sp³ C–H bonds with diarylhyperiodonium salts via Pd catalysis

Organic Letters, v. 15, (18), September 2013, p. 4758-4761
Pan, Fei; Shen, Peng-Xiang; Zhang, Lisheng; Wang, Xin; Shi, Zhang-Jie

Palladium-catalyzed trifluoromethylation of aromatic C–H bond directed by an acetamino group

Organic Letters, v. 15, (1), January 2013, p. 10-13
Zhang, Lisheng; Chen, Kang; Chen, Guihua; Li, Bi-Jie; Luo, Shuang; Guo, Qing-Yun; Wei, Jiangbo; Shi, Zhang-Jie

Article 1

Reductive Cleavage of the C_sp2–C_sp3 Bond of Secondary Benzyl Alcohols: Rhodium Catalysis Directed by N-Containing Groups

Angewandte Chemie - International Edition, v. 51, (39), September 2012, p. 9851-9855
Chen, Kang; Li, Hu; Lei, Zhi-Quan; Ye, Wen-He; Zhang, Lisheng; Sun, Jian; Shi, Zhang-Jie

2016 2

Direct Oxidation of Aliphatic C–H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Organic Letters, v. 18, (6), March 2016, p. 1234-1237
Li, Xin; Che, Xing; Chen, Gui-Hua; Zhang, Jun; Yan, Jia-Lei; Zhang, Yun-Fei; Zhang, Lisheng; Hsu, Chao-Ping; Gao, Yi Qin; Shi, Zhang-Jie
Article

Nickel- or iron- catalyzed cross-coupling of aryl carbamates with arylsilanes

Advanced Synthesis and Catalysis, v. 358, (15), July 2016, p. 2410-2416
Shi, Wen-Juan; Zhao, Hong-Wei; Wang, Yang; Cao, Zhi-Chao; Zhang, Lisheng; Yu, Da-Gang; Shi, Zhang-Jie
Article

2014 1

Direct borylation of primary C–H bonds in functionalized molecules by palladium catalysis

Angewandte Chemie - International Edition, v. 53, (15), April 2014, p. 3899-3903
Zhang, Lisheng; Chen, Guihua; Wang, Xin; Guo, Qing-Yun; Zhang, Xi-Sha; Pan, Fei; Chen, Kang; Shi, Zhang-Jie
Article

2013 2

Direct arylation of primary and secondary sp³ C–H bonds with diarylhyperiodonium salts via Pd catalysis

Organic Letters, v. 15, (18), September 2013, p. 4758-4761
Pan, Fei; Shen, Peng-Xiang; Zhang, Lisheng; Wang, Xin; Shi, Zhang-Jie
Article

Palladium-catalyzed trifluoromethylation of aromatic C–H bond directed by an acetamino group

Organic Letters, v. 15, (1), January 2013, p. 10-13
Zhang, Lisheng; Chen, Kang; Chen, Guihua; Li, Bi-Jie; Luo, Shuang; Guo, Qing-Yun; Wei, Jiangbo; Shi, Zhang-Jie
Article

2012 1

Reductive Cleavage of the C_sp2–C_sp3 Bond of Secondary Benzyl Alcohols: Rhodium Catalysis Directed by N-Containing Groups

Angewandte Chemie - International Edition, v. 51, (39), September 2012, p. 9851-9855
Chen, Kang; Li, Hu; Lei, Zhi-Quan; Ye, Wen-He; Zhang, Lisheng; Sun, Jian; Shi, Zhang-Jie
Article

No Publications

Teaching Assignment

2023-24 Fall 3 2022-23 Summer 0 2022-23 Spring 0 2022-23 Winter 0 2022-23 Fall 0 2021-22 Summer 0

LIFS6111S	Life Science Postgraduate Student Seminar
LIFS6114G	Current Topics in Biotechnology and Traditional Chinese Medicine
SCIE3500	IRE Research Project I

Research Interest

Publications

2023 4

2022 4

2021 4

2020 2

2019 2

2016 2

2014 1

2013 2

2012 1

Article 3

Book chapter 1

Article 4

Article 3

Book chapter 1

Article 2

Article 2

Article 2

Article 1

Article 2

Article 1

2016 2

2014 1

2013 2

2012 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2020 to December 2023 (As of 30 September 2023)

Current RPGs

Projects

From January 2021 to December 2023

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