Faculty Profiles - ZHANG Lisheng | The Hong Kong University of Science and Technology

Lisheng ZHANG
張理升

PhD in Chemistry
The University of Chicago, 2019

Assistant Professor
Division of Life Science
Department of Chemistry

(852) 3469 2392
zhangls@ust.hk
Room 5445
Personal Web

Google Scholar

YMZv4UAAAAAJ

ORCID

0000-0003-1872-9978

Scopus ID

56514199600

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Epigenetics
Chemical biology
Immunology
Cancer
Computational biology

Publications

All Years 33 2025 1 2024 6 2023 8 2022 4 2021 4 2020 2 2019 8

2025 1

Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation

Nature Plants, v. 11, (2), February 2025, article number eadg1805, p. 234-247
Li, Haoxuan; Wang, Guanqun; Ye, Chang; Zou, Zhongyu; Jiang, Bochen; Yang, Fan; He, Kayla; Ju, Cheng-Wei; Zhang, Lisheng; Gao, Boyang; Liu, Shun; Chen, Yanming; Zhang, Jianhua; He, Chuan
Article

2024 6

2′-O-methylation at internal sites on mRNA promotes mRNA stability

Molecular Cell, v. 84, (12), June 2024, p. 2320-2336
Li, Yanqiang; Yang, Li; Gao, Xinlei; Wang, Xin; Zhao, Dongyu; Wang, Rui; Zhang, Lisheng; Gao, Boyang; Zhang, Yadong; Zhang, Lili; Cao, Qi; Chen, Kaifu
Article

A Quantitative Sequencing Method for 5-Formylcytosine in RNA

Israel Journal of Chemistry, v. 64, (3-4), April 2024, article number e202300111
Lyu, Ruitu; Pajdzik, Kinga; Sun, Hui-Lung; Zhang, Linda; Zhang, Lisheng; Wu, Tong; Yang, Lei; Pan, Tao; He, Chuan; Dai, Qing
Article

Base-Resolution Sequencing Methods for Whole-Transcriptome Quantification of mRNA Modifications

Accounts of Chemical Research, v. 57, (1), January 2024, p. 47-58
Zhang, Lisheng; Dai, Qing; He, Chuan
Article

Chemical manipulation of m¹A mediates its detection in human tRNA

RNA, v. 30, (5), May 2024, p. 548-559
Pajdzik, Kinga; Lyu, Ruitu; Dou, Xiaoyang; Ye, Chang; Zhang, Lisheng; Dai, Qing; He, Chuan
Article

IGF2BP3 promotes mRNA degradation through internal m⁷G modification

Nature Communications, v. 15, (1), December 2024, article number 7421, p. 1-16
Liu, Chang; Dou, Xiaoyang; Zhao, Yutao; Zhang, Linda; Zhang, Lisheng; Dai, Qing; Liu, Jun; Wu, Tong; Xiao, Yu; He, Chuan
Article

Sequencing of N⁶-methyl-deoxyadenosine at single-base resolution across the mammalian genome

Molecular Cell, v. 84, (3), February 2024, p. 596-610.e6
Feng, Xinran; Cui, Xiao-Long; Zhang, Lisheng; Ye, Chang; Wang, Pingluan; Zhong, Yuhao; Zheng, Zhong; He, Chuan
Article

2023 8

BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution

Nature Protocols, November 2023
Zhang, Lisheng; Ye, Chang; Ju, Cheng-Wei; Gao, Boyang; Feng, Xinran; Sun, Hui-Lung; Wei, Jiangbo; Yang, Fan; Dai, Qing; He, Chuan
Article

BID-seq: The Quantitative and Base-Resolution Sequencing Method for RNA Pseudouridine

ACS Chemical Biology, v. 18, (1), January 2023, p. 4-6
Zhang, Lisheng; Dai, Qing; He, Chuan
Article

Exon architecture controls mRNA m⁶A suppression and gene expression

Science, v. 379, (6633), February 2023, p. 677-682
He, P. Cody; Wei, Jiangbo; Dou, Xiaoyang; Harada, Bryan T.; Zhang, Zijie; Ge, Ruiqi; Liu, Chang; Zhang, Lisheng; Yu, Xianbin; Wang, Shuai; Lyu, Ruitu; Zou, Zhongyu; Chen, Mengjie; He, Chuan
Article

Quantitative sequencing uncovers abundant pseudouridines in mammalian mRNA at base resolution

Nature Biotechnology, v. 41, March 2023, p. 344-354
Dai, Qing; Zhang, Lisheng; Sun, Hui-Lung; Pajdzik, Kinga; Yang, Lei; Ye, Chang; Ju, Cheng-Wei; Liu, Shun; Wang, Yuru; Zheng, Zhong; Zhang, Linda; Harada, Bryan T.; Dou, Xiaoyang; Irkliyenko, Iryna; Feng, Xinran; Zhang, Wen; Pan, Tao; He, Chuan
Article

The regulation of antiviral innate immunity through non-m⁶A RNA modifications

Frontiers in Immunology, v. 14, October 2023, article number 1286820
Shen, Shenghai; Zhang, Lisheng
Article

Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA

Methods in Enzymology, v. 692 / Cambridge, Massachusetts : Elsevier, 2023, p. 39-54, Ch. 3
Zhang, Lisheng; Ju, Cheng-Wei; Jiang, Bochen; He, Chuan
Book chapter

Quantitative base-resolution sequencing technology for mapping pseudouridines in mammalian mRNA

Methods in Enzymology / Cambridge, Massachusetts : Elsevier, 2023
Zhang, Lisheng; Dai, Qing; He, Chuan
Book chapter

5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons

DiscoverBMB: ASBMB Annual Meeting Abstracts, v. 299, (3, Supplement), 2023, article number 104261, Abstract 2659
Zhang, Yuexiu; Zhang, Lisheng; Dai, Qing; Xu, Jiayu; Chen, Phylip; Peeples, Mark; Sharma, Amit; He, Chuan; Li, Jianrong
Conference paper

2022 4

5-methylcytosine (m⁵C) RNA modification controls the innate immune response to virus infection by regulating type I interferons

Proceedings of the National Academy of Sciences of the United States of America, v. 119, (42), October 2022, article number e2123338119
Zhang, Yuexiu; Zhang, Lisheng; Dai, Qing; Chen, Phylip; Lu, Mijia; Kairis, Elizabeth L.; Murugaiah, Valarmathy; Xu, Jiayu; Shukla, Rajni Kant; Liang, Xueya; Zou, Zhongyu; Cormet-Boyaka, Estelle; Qiu, Jianming; Peeples, Mark E.; Sharma, Amit; He, Chuan; Li, Jianrong
Article

FTO mediates LINE1 m⁶A demethylation and chromatin regulation in mESCs and mouse development

Science, v. 376, (6596), May 2022, article number eabe9582, p. 968-973
Wei, Jiangbo; Zhang, Lisheng; Gao, Shaorong; Gao, Yawei; He, Chuan
Article

m⁶A RNA modifications are measured at single-base resolution across the mammalian transcriptome

Nature Biotechnology, v. 40, (8), August 2022, p. 1210-1219
Hu, Lulu; Liu, Shun; Peng, Yong; Ge, Ruiqi; Su, Rui; Senevirathne, Chamara; Harada, Bryan T.; Dai, Qing; Wei, Jiangbo; Zhang, Lisheng; Hao, Ziyang; Luo, Liangzhi; Wang, Huanyu; Wang, Yuru; Luo, Minkui; Chen, Mengjie; Chen, Jianjun; He, Chuan
Article

m⁷G-quant-seq: Quantitative Detection of RNA Internal N⁷-Methylguanosine

ACS Chemical Biology, v. 17, (12), December 2022, p. 3306-3312
Zhang, Lisheng; Ju, Cheng-Wei; Liu, Chang; Wei, Jiangbo; Dai, Qing; Chen, Li; Ye, Chang; He, Chuan
Article

2021 4

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Molecular Cell, v. 81, (20), 21 October 2021, p. 4228-4242
Tsao, Ning; Brickner, Joshua R.; Rodell, Rebecca; Ganguly, Adit; Wood, Matthew; Oyeniran, Clement; Ahmad, Tanveer; Sun, Hua; Bacolla, Albino; Zhang, Lisheng; Lukinović, Valentina; Soll, Jennifer M.; Townley, Brittany A.; Casanova, Alexandre G.; Tainer, John A.; He, Chuan; Vindigni, Alessandro; Reynoird, Nicolas; Mosammaparast, Nima
Article

ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing

Nature Cell Biology, v. 23, (7), July 2021, p. 684-691
Zhang, Lisheng; Xiong, Qing-Ping; Peña Perez, Sonia; Liu, Chang; Wei, Jiangbo; Le, Cassy; Zhang, Linda; Harada, Bryan T.; Dai, Qing; Feng, Xinran; Hao, Ziyang; Wang, Yuru; Dong, Xueyang; Hu, Lulu; Wang, En-Duo; Pan, Tao; Klungland, Arne; Liu, Ru-Juan; He, Chuan
Article

LEAD-m⁶A-seq for Locus-Specific Detection of N⁶-Methyladenosine and Quantification of Differential Methylation

Angewandte Chemie - International Edition, v. 60, (2), January 2021, p. 873-880
Wang, Yuru; Zhang, Zijie; Sepich-Poore, Caraline; Zhang, Lisheng; Xiao, Yu; He, Chuan
Article

Transcriptome-Wide Detection of Internal N⁷-Methylguanosine

Methods in Molecular Biology, v. 2298 / edited by Mary McMahon. New York, NY : Humana, 2021, p. 97-104
Zhang, Lisheng; Liu, Chang; He, Chuan
Book chapter

2020 2

DNA 5-Methylcytosine-Specific Amplification and Sequencing

Journal of the American Chemical Society, v. 142, (10), March 2020, p. 4539-4543
Liu, Chang; Cui, Xiaolong; Zhao, Boxuan Simen; Narkhede, Pradnya; Gao, Yawei; Liu, Jun; Dou, Xiaoyang; Dai, Qing; Zhang, Lisheng; He, Chuan
Article

N⁶-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA

Molecular Cell, v. 78, (3), May 2020, p. 382-395
Hao, Ziyang; Wu, Tong; Cui, Xiaolong; Zhu, Pingping; Tan, Caiping; Dou, Xiaoyang; Hsu, Kai-Wen; Lin, Yueh-Te; Peng, Pei-Hua; Zhang, Lisheng; Gao, Yiwei; Hu, Lulu; Sun, Hui-Lung; Zhu, Allen; Liu, Jianzhao; Wu, Kou-Juey; He, Chuan
Article

2019 2

Transcriptome-wide Mapping of Internal N⁷-Methylguanosine Methylome in Mammalian mRNA

Molecular Cell, v. 74, (6), 20 June 2019, p. 1304-1316
Zhang, Lisheng; Liu, Chang; Ma, Honghui; Dai, Qing; Sun, Hui-Lung; Luo, Guanzheng; Zhang, Zijie; Zhang, Linda; Hu, Lulu; Dong, Xueyang; He, Chuan
Article

tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance

Cell Systems, v. 8, (4), 24 April 2019, p. 302-314
Masuda, Isao; Matsubara, Ryuma; Christian, Thomas; Rojas, Enrique R.; Yadavalli, Srujana S.; Zhang, Lisheng; Goulian, Mark; Foster, Leonard J.; Huang, Kerwyn Casey; Hou, Ya-Ming
Article

2016 2

Direct Oxidation of Aliphatic C–H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Organic Letters, v. 18, (6), March 2016, p. 1234-1237
Li, Xin; Che, Xing; Chen, Gui-Hua; Zhang, Jun; Yan, Jia-Lei; Zhang, Yun-Fei; Zhang, Lisheng; Hsu, Chao-Ping; Gao, Yi Qin; Shi, Zhang-Jie
Article

Nickel- or iron- catalyzed cross-coupling of aryl carbamates with arylsilanes

Advanced Synthesis and Catalysis, v. 358, (15), July 2016, p. 2410-2416
Shi, Wen-Juan; Zhao, Hong-Wei; Wang, Yang; Cao, Zhi-Chao; Zhang, Lisheng; Yu, Da-Gang; Shi, Zhang-Jie
Article

2014 1

Direct borylation of primary C–H bonds in functionalized molecules by palladium catalysis

Angewandte Chemie - International Edition, v. 53, (15), April 2014, p. 3899-3903
Zhang, Lisheng; Chen, Guihua; Wang, Xin; Guo, Qing-Yun; Zhang, Xi-Sha; Pan, Fei; Chen, Kang; Shi, Zhang-Jie
Article

2013 2

Direct arylation of primary and secondary sp³ C–H bonds with diarylhyperiodonium salts via Pd catalysis

Organic Letters, v. 15, (18), September 2013, p. 4758-4761
Pan, Fei; Shen, Peng-Xiang; Zhang, Lisheng; Wang, Xin; Shi, Zhang-Jie
Article

Palladium-catalyzed trifluoromethylation of aromatic C–H bond directed by an acetamino group

Organic Letters, v. 15, (1), January 2013, p. 10-13
Zhang, Lisheng; Chen, Kang; Chen, Guihua; Li, Bi-Jie; Luo, Shuang; Guo, Qing-Yun; Wei, Jiangbo; Shi, Zhang-Jie
Article

2012 1

Reductive Cleavage of the C_sp2–C_sp3 Bond of Secondary Benzyl Alcohols: Rhodium Catalysis Directed by N-Containing Groups

Angewandte Chemie - International Edition, v. 51, (39), September 2012, p. 9851-9855
Chen, Kang; Li, Hu; Lei, Zhi-Quan; Ye, Wen-He; Zhang, Lisheng; Sun, Jian; Shi, Zhang-Jie
Article

Article 1

Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation

Nature Plants, v. 11, (2), February 2025, article number eadg1805, p. 234-247
Li, Haoxuan; Wang, Guanqun; Ye, Chang; Zou, Zhongyu; Jiang, Bochen; Yang, Fan; He, Kayla; Ju, Cheng-Wei; Zhang, Lisheng; Gao, Boyang; Liu, Shun; Chen, Yanming; Zhang, Jianhua; He, Chuan

Article 6

2′-O-methylation at internal sites on mRNA promotes mRNA stability

Molecular Cell, v. 84, (12), June 2024, p. 2320-2336
Li, Yanqiang; Yang, Li; Gao, Xinlei; Wang, Xin; Zhao, Dongyu; Wang, Rui; Zhang, Lisheng; Gao, Boyang; Zhang, Yadong; Zhang, Lili; Cao, Qi; Chen, Kaifu

A Quantitative Sequencing Method for 5-Formylcytosine in RNA

Israel Journal of Chemistry, v. 64, (3-4), April 2024, article number e202300111
Lyu, Ruitu; Pajdzik, Kinga; Sun, Hui-Lung; Zhang, Linda; Zhang, Lisheng; Wu, Tong; Yang, Lei; Pan, Tao; He, Chuan; Dai, Qing

Base-Resolution Sequencing Methods for Whole-Transcriptome Quantification of mRNA Modifications

Accounts of Chemical Research, v. 57, (1), January 2024, p. 47-58
Zhang, Lisheng; Dai, Qing; He, Chuan

Chemical manipulation of m¹A mediates its detection in human tRNA

RNA, v. 30, (5), May 2024, p. 548-559
Pajdzik, Kinga; Lyu, Ruitu; Dou, Xiaoyang; Ye, Chang; Zhang, Lisheng; Dai, Qing; He, Chuan

IGF2BP3 promotes mRNA degradation through internal m⁷G modification

Nature Communications, v. 15, (1), December 2024, article number 7421, p. 1-16
Liu, Chang; Dou, Xiaoyang; Zhao, Yutao; Zhang, Linda; Zhang, Lisheng; Dai, Qing; Liu, Jun; Wu, Tong; Xiao, Yu; He, Chuan

Sequencing of N⁶-methyl-deoxyadenosine at single-base resolution across the mammalian genome

Molecular Cell, v. 84, (3), February 2024, p. 596-610.e6
Feng, Xinran; Cui, Xiao-Long; Zhang, Lisheng; Ye, Chang; Wang, Pingluan; Zhong, Yuhao; Zheng, Zhong; He, Chuan

Article 5

BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution

Nature Protocols, November 2023
Zhang, Lisheng; Ye, Chang; Ju, Cheng-Wei; Gao, Boyang; Feng, Xinran; Sun, Hui-Lung; Wei, Jiangbo; Yang, Fan; Dai, Qing; He, Chuan

BID-seq: The Quantitative and Base-Resolution Sequencing Method for RNA Pseudouridine

ACS Chemical Biology, v. 18, (1), January 2023, p. 4-6
Zhang, Lisheng; Dai, Qing; He, Chuan

Exon architecture controls mRNA m⁶A suppression and gene expression

Science, v. 379, (6633), February 2023, p. 677-682
He, P. Cody; Wei, Jiangbo; Dou, Xiaoyang; Harada, Bryan T.; Zhang, Zijie; Ge, Ruiqi; Liu, Chang; Zhang, Lisheng; Yu, Xianbin; Wang, Shuai; Lyu, Ruitu; Zou, Zhongyu; Chen, Mengjie; He, Chuan

Quantitative sequencing uncovers abundant pseudouridines in mammalian mRNA at base resolution

Nature Biotechnology, v. 41, March 2023, p. 344-354
Dai, Qing; Zhang, Lisheng; Sun, Hui-Lung; Pajdzik, Kinga; Yang, Lei; Ye, Chang; Ju, Cheng-Wei; Liu, Shun; Wang, Yuru; Zheng, Zhong; Zhang, Linda; Harada, Bryan T.; Dou, Xiaoyang; Irkliyenko, Iryna; Feng, Xinran; Zhang, Wen; Pan, Tao; He, Chuan

The regulation of antiviral innate immunity through non-m⁶A RNA modifications

Frontiers in Immunology, v. 14, October 2023, article number 1286820
Shen, Shenghai; Zhang, Lisheng

Book chapter 2

Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA

Methods in Enzymology, v. 692 / Cambridge, Massachusetts : Elsevier, 2023, p. 39-54, Ch. 3
Zhang, Lisheng; Ju, Cheng-Wei; Jiang, Bochen; He, Chuan

Quantitative base-resolution sequencing technology for mapping pseudouridines in mammalian mRNA

Methods in Enzymology / Cambridge, Massachusetts : Elsevier, 2023
Zhang, Lisheng; Dai, Qing; He, Chuan

Conference paper 1

5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons

DiscoverBMB: ASBMB Annual Meeting Abstracts, v. 299, (3, Supplement), 2023, article number 104261, Abstract 2659
Zhang, Yuexiu; Zhang, Lisheng; Dai, Qing; Xu, Jiayu; Chen, Phylip; Peeples, Mark; Sharma, Amit; He, Chuan; Li, Jianrong

Article 4

5-methylcytosine (m⁵C) RNA modification controls the innate immune response to virus infection by regulating type I interferons

Proceedings of the National Academy of Sciences of the United States of America, v. 119, (42), October 2022, article number e2123338119
Zhang, Yuexiu; Zhang, Lisheng; Dai, Qing; Chen, Phylip; Lu, Mijia; Kairis, Elizabeth L.; Murugaiah, Valarmathy; Xu, Jiayu; Shukla, Rajni Kant; Liang, Xueya; Zou, Zhongyu; Cormet-Boyaka, Estelle; Qiu, Jianming; Peeples, Mark E.; Sharma, Amit; He, Chuan; Li, Jianrong

FTO mediates LINE1 m⁶A demethylation and chromatin regulation in mESCs and mouse development

Science, v. 376, (6596), May 2022, article number eabe9582, p. 968-973
Wei, Jiangbo; Zhang, Lisheng; Gao, Shaorong; Gao, Yawei; He, Chuan

m⁶A RNA modifications are measured at single-base resolution across the mammalian transcriptome

Nature Biotechnology, v. 40, (8), August 2022, p. 1210-1219
Hu, Lulu; Liu, Shun; Peng, Yong; Ge, Ruiqi; Su, Rui; Senevirathne, Chamara; Harada, Bryan T.; Dai, Qing; Wei, Jiangbo; Zhang, Lisheng; Hao, Ziyang; Luo, Liangzhi; Wang, Huanyu; Wang, Yuru; Luo, Minkui; Chen, Mengjie; Chen, Jianjun; He, Chuan

m⁷G-quant-seq: Quantitative Detection of RNA Internal N⁷-Methylguanosine

ACS Chemical Biology, v. 17, (12), December 2022, p. 3306-3312
Zhang, Lisheng; Ju, Cheng-Wei; Liu, Chang; Wei, Jiangbo; Dai, Qing; Chen, Li; Ye, Chang; He, Chuan

Article 3

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Molecular Cell, v. 81, (20), 21 October 2021, p. 4228-4242
Tsao, Ning; Brickner, Joshua R.; Rodell, Rebecca; Ganguly, Adit; Wood, Matthew; Oyeniran, Clement; Ahmad, Tanveer; Sun, Hua; Bacolla, Albino; Zhang, Lisheng; Lukinović, Valentina; Soll, Jennifer M.; Townley, Brittany A.; Casanova, Alexandre G.; Tainer, John A.; He, Chuan; Vindigni, Alessandro; Reynoird, Nicolas; Mosammaparast, Nima

ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing

Nature Cell Biology, v. 23, (7), July 2021, p. 684-691
Zhang, Lisheng; Xiong, Qing-Ping; Peña Perez, Sonia; Liu, Chang; Wei, Jiangbo; Le, Cassy; Zhang, Linda; Harada, Bryan T.; Dai, Qing; Feng, Xinran; Hao, Ziyang; Wang, Yuru; Dong, Xueyang; Hu, Lulu; Wang, En-Duo; Pan, Tao; Klungland, Arne; Liu, Ru-Juan; He, Chuan

LEAD-m⁶A-seq for Locus-Specific Detection of N⁶-Methyladenosine and Quantification of Differential Methylation

Angewandte Chemie - International Edition, v. 60, (2), January 2021, p. 873-880
Wang, Yuru; Zhang, Zijie; Sepich-Poore, Caraline; Zhang, Lisheng; Xiao, Yu; He, Chuan

Book chapter 1

Transcriptome-Wide Detection of Internal N⁷-Methylguanosine

Methods in Molecular Biology, v. 2298 / edited by Mary McMahon. New York, NY : Humana, 2021, p. 97-104
Zhang, Lisheng; Liu, Chang; He, Chuan

Article 2

DNA 5-Methylcytosine-Specific Amplification and Sequencing

Journal of the American Chemical Society, v. 142, (10), March 2020, p. 4539-4543
Liu, Chang; Cui, Xiaolong; Zhao, Boxuan Simen; Narkhede, Pradnya; Gao, Yawei; Liu, Jun; Dou, Xiaoyang; Dai, Qing; Zhang, Lisheng; He, Chuan

N⁶-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA

Molecular Cell, v. 78, (3), May 2020, p. 382-395
Hao, Ziyang; Wu, Tong; Cui, Xiaolong; Zhu, Pingping; Tan, Caiping; Dou, Xiaoyang; Hsu, Kai-Wen; Lin, Yueh-Te; Peng, Pei-Hua; Zhang, Lisheng; Gao, Yiwei; Hu, Lulu; Sun, Hui-Lung; Zhu, Allen; Liu, Jianzhao; Wu, Kou-Juey; He, Chuan

Article 2

Transcriptome-wide Mapping of Internal N⁷-Methylguanosine Methylome in Mammalian mRNA

Molecular Cell, v. 74, (6), 20 June 2019, p. 1304-1316
Zhang, Lisheng; Liu, Chang; Ma, Honghui; Dai, Qing; Sun, Hui-Lung; Luo, Guanzheng; Zhang, Zijie; Zhang, Linda; Hu, Lulu; Dong, Xueyang; He, Chuan

tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance

Cell Systems, v. 8, (4), 24 April 2019, p. 302-314
Masuda, Isao; Matsubara, Ryuma; Christian, Thomas; Rojas, Enrique R.; Yadavalli, Srujana S.; Zhang, Lisheng; Goulian, Mark; Foster, Leonard J.; Huang, Kerwyn Casey; Hou, Ya-Ming

Article 2

Direct Oxidation of Aliphatic C–H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Organic Letters, v. 18, (6), March 2016, p. 1234-1237
Li, Xin; Che, Xing; Chen, Gui-Hua; Zhang, Jun; Yan, Jia-Lei; Zhang, Yun-Fei; Zhang, Lisheng; Hsu, Chao-Ping; Gao, Yi Qin; Shi, Zhang-Jie

Nickel- or iron- catalyzed cross-coupling of aryl carbamates with arylsilanes

Advanced Synthesis and Catalysis, v. 358, (15), July 2016, p. 2410-2416
Shi, Wen-Juan; Zhao, Hong-Wei; Wang, Yang; Cao, Zhi-Chao; Zhang, Lisheng; Yu, Da-Gang; Shi, Zhang-Jie

Article 1

Direct borylation of primary C–H bonds in functionalized molecules by palladium catalysis

Angewandte Chemie - International Edition, v. 53, (15), April 2014, p. 3899-3903
Zhang, Lisheng; Chen, Guihua; Wang, Xin; Guo, Qing-Yun; Zhang, Xi-Sha; Pan, Fei; Chen, Kang; Shi, Zhang-Jie

Article 2

Direct arylation of primary and secondary sp³ C–H bonds with diarylhyperiodonium salts via Pd catalysis

Organic Letters, v. 15, (18), September 2013, p. 4758-4761
Pan, Fei; Shen, Peng-Xiang; Zhang, Lisheng; Wang, Xin; Shi, Zhang-Jie

Palladium-catalyzed trifluoromethylation of aromatic C–H bond directed by an acetamino group

Organic Letters, v. 15, (1), January 2013, p. 10-13
Zhang, Lisheng; Chen, Kang; Chen, Guihua; Li, Bi-Jie; Luo, Shuang; Guo, Qing-Yun; Wei, Jiangbo; Shi, Zhang-Jie

Article 1

Reductive Cleavage of the C_sp2–C_sp3 Bond of Secondary Benzyl Alcohols: Rhodium Catalysis Directed by N-Containing Groups

Angewandte Chemie - International Edition, v. 51, (39), September 2012, p. 9851-9855
Chen, Kang; Li, Hu; Lei, Zhi-Quan; Ye, Wen-He; Zhang, Lisheng; Sun, Jian; Shi, Zhang-Jie

2019 2

Transcriptome-wide Mapping of Internal N⁷-Methylguanosine Methylome in Mammalian mRNA

Molecular Cell, v. 74, (6), 20 June 2019, p. 1304-1316
Zhang, Lisheng; Liu, Chang; Ma, Honghui; Dai, Qing; Sun, Hui-Lung; Luo, Guanzheng; Zhang, Zijie; Zhang, Linda; Hu, Lulu; Dong, Xueyang; He, Chuan
Article

tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance

Cell Systems, v. 8, (4), 24 April 2019, p. 302-314
Masuda, Isao; Matsubara, Ryuma; Christian, Thomas; Rojas, Enrique R.; Yadavalli, Srujana S.; Zhang, Lisheng; Goulian, Mark; Foster, Leonard J.; Huang, Kerwyn Casey; Hou, Ya-Ming
Article

2016 2

Direct Oxidation of Aliphatic C–H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Organic Letters, v. 18, (6), March 2016, p. 1234-1237
Li, Xin; Che, Xing; Chen, Gui-Hua; Zhang, Jun; Yan, Jia-Lei; Zhang, Yun-Fei; Zhang, Lisheng; Hsu, Chao-Ping; Gao, Yi Qin; Shi, Zhang-Jie
Article

Nickel- or iron- catalyzed cross-coupling of aryl carbamates with arylsilanes

Advanced Synthesis and Catalysis, v. 358, (15), July 2016, p. 2410-2416
Shi, Wen-Juan; Zhao, Hong-Wei; Wang, Yang; Cao, Zhi-Chao; Zhang, Lisheng; Yu, Da-Gang; Shi, Zhang-Jie
Article

2014 1

Direct borylation of primary C–H bonds in functionalized molecules by palladium catalysis

Angewandte Chemie - International Edition, v. 53, (15), April 2014, p. 3899-3903
Zhang, Lisheng; Chen, Guihua; Wang, Xin; Guo, Qing-Yun; Zhang, Xi-Sha; Pan, Fei; Chen, Kang; Shi, Zhang-Jie
Article

2013 2

Direct arylation of primary and secondary sp³ C–H bonds with diarylhyperiodonium salts via Pd catalysis

Organic Letters, v. 15, (18), September 2013, p. 4758-4761
Pan, Fei; Shen, Peng-Xiang; Zhang, Lisheng; Wang, Xin; Shi, Zhang-Jie
Article

Palladium-catalyzed trifluoromethylation of aromatic C–H bond directed by an acetamino group

Organic Letters, v. 15, (1), January 2013, p. 10-13
Zhang, Lisheng; Chen, Kang; Chen, Guihua; Li, Bi-Jie; Luo, Shuang; Guo, Qing-Yun; Wei, Jiangbo; Shi, Zhang-Jie
Article

2012 1

Reductive Cleavage of the C_sp2–C_sp3 Bond of Secondary Benzyl Alcohols: Rhodium Catalysis Directed by N-Containing Groups

Angewandte Chemie - International Edition, v. 51, (39), September 2012, p. 9851-9855
Chen, Kang; Li, Hu; Lei, Zhi-Quan; Ye, Wen-He; Zhang, Lisheng; Sun, Jian; Shi, Zhang-Jie
Article

Teaching Assignment

2024-25 Spring 2 2024-25 Winter 0 2024-25 Fall 3 2023-24 Summer 0 2023-24 Spring 6 2023-24 Winter 0

LIFS4060	Immunobiology
SCIE1120	Chemistry and Life

LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS6114H	Current Topics in Biotechnology and Traditional Chinese Medicine
SCIE4500	IRE Research Project II

CHEM4680	Undergraduate Research
LIFS4060	Immunobiology
LIFS4963	Biotechnology Capstone Project
LIFS4981	Biochemistry and Cell Biology Project Research II
LIFS4983	Biotechnology Project Research II
SCIE1500	Guided Study on Research I

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 20 April 2025)

Current RPGs

Doctor of Philosophy

REN, Shuxing
Life Science
SHEN, Yitong
Life Science
LIU, Weijin
Life Science
LU, Jijun
Life Science
SHEN, Shenghai
Life Science

Master of Philosophy

CHAN, Hei Man
Life Science
TSE, Man Hin
Life Science

Projects

From January 2023 to December 2025

All Projects 1

No Projects.
Quantitative base-resolution sequencing technology to study biological functions of RNA modifications

運用單鹼基分辨率定量測序技術研究RNA修飾的生物學功能 Leading

RGC - Early Career Scheme
Project Team (HKUST)
ZHANG Lisheng (Lead)
2024 -

Research Interest

Publications

2025 1

2024 6

2023 8

2022 4

2021 4

2020 2

2019 2

2016 2

2014 1

2013 2

2012 1

Article 1

Article 6

Article 5

Book chapter 2

Conference paper 1

Article 4

Article 3

Book chapter 1

Article 2

Article 2

Article 2

Article 1

Article 2

Article 1

2019 2

2016 2

2014 1

2013 2

2012 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 20 April 2025)

Current RPGs

Projects

From January 2023 to December 2025

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