Faculty Profiles - WANG Lan | The Hong Kong University of Science and Technology

Lan WANG
王瀾

PhD in Chemistry
Harvard University, 2016

Assistant Professor
Division of Life Science

(852) 2358 7271
lanwang@ust.hk
Room 5472
Personal Web

ORCID

0000-0002-8931-7201

Scopus ID

57214807697

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Structural biology
Cell biology
Membrane trafficking
Disease mechanisms

Publications

All Years 12 2024 1 2023 1 2022 2 2021 2 2020 2 2019 0 2018 4

2024 1

A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling

Nature Chemical Biology, v. 20, (4), April 2024, p. 422-431
Lawrence, Rosalie E.; Shoemaker, Sophie R.; Deal, Aniliese; Sangwan, Smriti; Anand, Aditya A.; Wang, Lan; Marqusee, Susan; Walter, Peter
Article

2023 1

A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response

Nature Cell Biology, v. 25, (11), October 2023, p. 1600-1615
Subramanian, Advait; Wang, Lan; Moss, Tom; Voorhies, Mark; Sangwan, Smriti; Stevenson, Erica; Pulido, Ernst; Kwok, Samentha; Chalkley, Robert; Li, Kathy; Krogan, Nevan; Swaney, Danielle; Burlingame, Alma; Floor, Stephen; Sil, Anita; Walter, Peter; Mukherjee, Shaeri
Article

2022 2

A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

eLife, v. 11, April 2022, article number e76171
Boone, Morgane; Wang, Lan; Lawrence, Rosalie E.; Frost, Adam; Walter, Peter; Schoof, Michael
Article

Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

eLife, v. 11, May 2022, article number e73941
Wang, Lan; Toutkoushian, Hanah; Belyy, Vladisav; Kokontis, Claire; Walter, Peter
Article

2021 2

eIF2B conformation and assembly state regulate the integrated stress response

eLife, v. 10, March 2021, article number e65703
Schoof, Michael; Boone, Morgane; Wang, Lan; Lawrence, Rosalie; Frost, Adam; Walter, Peter
Article

Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B

Nature Communications, v. 12, (1), December 2021, article number 7013
Schoof, Michael; Wang, Lan; Cogan, J. Zachery; Lawrence, Rosalie E.; Boone, Morgane; Wuerth, Jennifer Deborah; Frost, Adam; Walter, Peter
Article

2020 2

Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities

Annual Review of Cell and Developmental Biology, v. 36, October 2020, p. 141-164
Wang, Lan; Walter, Peter
Article

Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

eLife, v. 9, January 2020, article number e54031
Wang, Lan; Myasnikov, Alexander; Pan, Xingjie; Walter, Peter
Article

2017 1

Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase

Journal of Biological Chemistry, v. 292, (12), March 2017, p. 5007-5017
Wang, Lan; Chakravarthy, Srinivas; Verdine, Gregory L.
Article

2015 1

Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase

Journal of Biological Chemistry, v. 290, (28), July 2015, p. 17096-17105
Wang, Lan; Lee, Seung-Joo; Verdine, Gregory L.
Article

2012 1

Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides’ connection with antimicrobial peptides

Biological Chemistry, v. 393, (7), July 2012, p. 641-646
Wang, Lan; Liu, Qian; Chen, Jin-Chun; Cui, Yi-Xian; Zhou, Bing; Chen, Yong-Xiang; Zhao, Yu-Fen; Li, Yan-Mei
Article

2009 1

Reactivity of [(2-Phosphino)ethenyl] zirconocene Chloride toward CpM(CO)3Cl (M=Mo, W): Formation of [(3-Phosphino)propenoyl] dicarbonyl (cyclopentadienyl) metal, {CpM(CO)2[(CO)CRdCRPPh2]}

Organometallics, v. 28, (23), November 2009, p. 6827-6830
Yan, Xiaoyu; Yu, Bingran; Wang, Lan; Tang, Ning; Xi, Chanjuan
Article

Article 1

A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling

Nature Chemical Biology, v. 20, (4), April 2024, p. 422-431
Lawrence, Rosalie E.; Shoemaker, Sophie R.; Deal, Aniliese; Sangwan, Smriti; Anand, Aditya A.; Wang, Lan; Marqusee, Susan; Walter, Peter

Article 1

A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response

Nature Cell Biology, v. 25, (11), October 2023, p. 1600-1615
Subramanian, Advait; Wang, Lan; Moss, Tom; Voorhies, Mark; Sangwan, Smriti; Stevenson, Erica; Pulido, Ernst; Kwok, Samentha; Chalkley, Robert; Li, Kathy; Krogan, Nevan; Swaney, Danielle; Burlingame, Alma; Floor, Stephen; Sil, Anita; Walter, Peter; Mukherjee, Shaeri

Article 2

A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

eLife, v. 11, April 2022, article number e76171
Boone, Morgane; Wang, Lan; Lawrence, Rosalie E.; Frost, Adam; Walter, Peter; Schoof, Michael

Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

eLife, v. 11, May 2022, article number e73941
Wang, Lan; Toutkoushian, Hanah; Belyy, Vladisav; Kokontis, Claire; Walter, Peter

Article 2

eIF2B conformation and assembly state regulate the integrated stress response

eLife, v. 10, March 2021, article number e65703
Schoof, Michael; Boone, Morgane; Wang, Lan; Lawrence, Rosalie; Frost, Adam; Walter, Peter

Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B

Nature Communications, v. 12, (1), December 2021, article number 7013
Schoof, Michael; Wang, Lan; Cogan, J. Zachery; Lawrence, Rosalie E.; Boone, Morgane; Wuerth, Jennifer Deborah; Frost, Adam; Walter, Peter

Article 2

Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities

Annual Review of Cell and Developmental Biology, v. 36, October 2020, p. 141-164
Wang, Lan; Walter, Peter

Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

eLife, v. 9, January 2020, article number e54031
Wang, Lan; Myasnikov, Alexander; Pan, Xingjie; Walter, Peter

Article 1

Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase

Journal of Biological Chemistry, v. 292, (12), March 2017, p. 5007-5017
Wang, Lan; Chakravarthy, Srinivas; Verdine, Gregory L.

Article 1

Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase

Journal of Biological Chemistry, v. 290, (28), July 2015, p. 17096-17105
Wang, Lan; Lee, Seung-Joo; Verdine, Gregory L.

Article 1

Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides’ connection with antimicrobial peptides

Biological Chemistry, v. 393, (7), July 2012, p. 641-646
Wang, Lan; Liu, Qian; Chen, Jin-Chun; Cui, Yi-Xian; Zhou, Bing; Chen, Yong-Xiang; Zhao, Yu-Fen; Li, Yan-Mei

Article 1

Reactivity of [(2-Phosphino)ethenyl] zirconocene Chloride toward CpM(CO)3Cl (M=Mo, W): Formation of [(3-Phosphino)propenoyl] dicarbonyl (cyclopentadienyl) metal, {CpM(CO)2[(CO)CRdCRPPh2]}

Organometallics, v. 28, (23), November 2009, p. 6827-6830
Yan, Xiaoyu; Yu, Bingran; Wang, Lan; Tang, Ning; Xi, Chanjuan

2017 1

Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase

Journal of Biological Chemistry, v. 292, (12), March 2017, p. 5007-5017
Wang, Lan; Chakravarthy, Srinivas; Verdine, Gregory L.
Article

2015 1

Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase

Journal of Biological Chemistry, v. 290, (28), July 2015, p. 17096-17105
Wang, Lan; Lee, Seung-Joo; Verdine, Gregory L.
Article

2012 1

Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides’ connection with antimicrobial peptides

Biological Chemistry, v. 393, (7), July 2012, p. 641-646
Wang, Lan; Liu, Qian; Chen, Jin-Chun; Cui, Yi-Xian; Zhou, Bing; Chen, Yong-Xiang; Zhao, Yu-Fen; Li, Yan-Mei
Article

2009 1

Reactivity of [(2-Phosphino)ethenyl] zirconocene Chloride toward CpM(CO)3Cl (M=Mo, W): Formation of [(3-Phosphino)propenoyl] dicarbonyl (cyclopentadienyl) metal, {CpM(CO)2[(CO)CRdCRPPh2]}

Organometallics, v. 28, (23), November 2009, p. 6827-6830
Yan, Xiaoyu; Yu, Bingran; Wang, Lan; Tang, Ning; Xi, Chanjuan
Article

No Publications

Teaching Assignment

2024-25 Fall 2 2023-24 Summer 0 2023-24 Spring 9 2023-24 Winter 0 2023-24 Fall 6 2022-23 Summer 1

LIFS2210	Biochemistry I
UROP2100N	Undergraduate Research Opportunities Series 2

LIFS4910A	Independent Study
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4981	Biochemistry and Cell Biology Project Research II
LIFS5260	Biochemical and Molecular Basis of Diseases
LIFS6115G	Current Topics in Development and Systems Biology
LIFS6660	Molecular Medicine
SCIE1500	Guided Study on Research I
UROP1100L	Undergraduate Research Opportunities Series 1
UROP2100L	Undergraduate Research Opportunities Series 2

LIFS2210	Biochemistry I
LIFS3520	Junior Research Project II
LIFS4910A	Independent Study
LIFS4971	Biochemistry and Cell Biology Project Research I
LIFS6111S	Life Science Postgraduate Student Seminar
UROP1100K	Undergraduate Research Opportunities Series 1

UROP1000

Undergraduate Research Opportunities

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

Current RPGs

Doctor of Philosophy

WANG, Jin
Life Science

Master of Philosophy

CHEN, Zhiqin
Life Science
LI, Yuke
Life Science
TIAN, Leyuan
Life Science
HE, Shuang
Life Science

Projects

From January 2022 to December 2024

All Projects 2

No Projects.
Mechanistic Elucidation of Mitochondria Quality Control Leading

Croucher Foundation
Project Team (HKUST)
WANG Lan (Lead)
2023 -
Structural investigation of ATAD1-mediated tail-anchored protein extraction on the outer mitochondrial membrane

關于ATAD1在線粒體質量控制中機理的研究 Leading

RGC - Early Career Scheme
Project Team (HKUST)
WANG Lan (Lead)
2023 -

Research Interest

Publications

2024 1

2023 1

2022 2

2021 2

2020 2

2017 1

2015 1

2012 1

2009 1

Article 1

Article 1

Article 2

Article 2

Article 2

Article 1

Article 1

Article 1

Article 1

2017 1

2015 1

2012 1

2009 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

Current RPGs

Projects

From January 2022 to December 2024

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