Faculty Profiles - MOK Kin Ying Boniface | The Hong Kong University of Science and Technology

Kin Ying Boniface MOK
莫健英

PhD in Neurogenetics
University College London, 2013

Clinical Professor
Division of Life Science

(852) 3469 3416
mok@ust.hk
Room 5486

ORCID

0000-0003-3145-880X

ResearcherID

F-5860-2012

Scopus ID

36437536800

Research Interest

Neuroscience
Neurodegenerative disease
Genetics

Publications

2025 1

Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease

Alzheimer's and Dementia, v. 21, (1), January 2025, article number e14214
Zhou, Xiaopu; Cao, Han; Jiang, Yuanbing; Chen, Yuewen; Zhong, Huan; Fu, Wing Yu; Lo, Ronnie Ming Nok; Wong, Bonnie Wing Yan; Cheng, Elaine Yee Ling; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Ip, Fanny C. F.; Miyashita, Akinori; Hara, Norikazu; Ikeuchi, Takeshi; Hardy, John; Chen, Yu; Fu, Amy K. Y.; Ip, Nancy Yuk-yu
Article

2024 2

A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups

Alzheimer's and Dementia, v. 20, (3), January 2024, p. 2000-2015
Jiang, Yuanbing; Uhm, Hyebin; Ip, Fanny C.; Ouyang, Li; Lo, Ronnie M. N.; Cheng, Elaine Y. L.; Cao, Xiaoyun; Tan, Clara M. C.; Law, Brian C. H.; Ortiz-Romero, Paula; Puig-Pijoan, Albert; Fernández-Lebrero, Aida; Contador, José; Mok, Kin Ying Boniface; Hardy, John; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Suárez-Calvet, Marc; Zetterberg, Henrik; Fu, Amy K. Y.; Ip, Nancy Yuk-yu
Article

Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification

Alzheimers & Dementia, v. 20, (4), April 2024, p. 2469-2484
Zhong, Huan; Zhou, Xiaopu; Uhm, Hyebin; Jiang, Yuanbing; Cao, Han; Chen, Yu; Mak, Tiffany T. W.; Lo, Ronnie Ming Nok; Wong, Bonnie Wing Yan; Cheng, Elaine Yee Ling; Mok, Kin Ying Boniface; Chan, Andrew Lung Tat; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Ip, Fanny Chui Fun; Hardy, John; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu
Article

2023 1

Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Communications Medicine, v. 3, April 2023, article number 49
Alzheimer’s Disease Neuroimaging Initiative; Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Lv, Ge; Zhang, Huan; Chen, Jiahang; Ye, Tao; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronnie M.N.; Tong, Pui Sze; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Guo, Qihao; Mok, Kin Ying Boniface; Shoai, Maryam; Hardy, John; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

2022 3

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Nature Aging, v. 2, (7), July 2022, p. 616-634
Jiang, Yuanbing; Zhou, Xiaopu; Wong, Hiu Yi; Ouyang, Li; Ip, Fanny Chui Fun; Chau, Man Ni; Lau, Shun Fat; Wu, Wei; Wong, Yew Kit Daniel; Seo, Heukjin; Fu, Wing Yu; Lai, Chit Hang; Chen, Yuewen; Chen, Yu; Tong, Pui Sze; Alzheimer’s Disease Neuroimaging Initiative; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Ying Boniface; Shoai, Maryam; Lehallier, Benoit; Losada, Patricia Moran; O'Brien, Eleanor; Porter, Tenielle; Laws, Simon M.; Hardy, John; Wyss-Coray, Tony; Masters, Colin L.; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Article

Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging

Alzheimer's & Dementia, v. 18, (1), January 2022, p. 88-102
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Nicole C. H.; Cheung, Kit; Lo, Ronnie M. N.; Tong, Pui Sze; Wong, Bonnie W. Y.; Chan, Andrew L. T.; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

Underrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future Directions

Movement Disorders, v. 37, (8), August 2022, p. 1593-1604
Schumacher-Schuh, Artur Francisco; Bieger, Andrei; Okunoye, Olaitan; Mok, Kin Ying Boniface; Lim, Shen-Yang; Bardien, Soraya; Ahmad-Annuar, Azlina; Santos-Lobato, Bruno Lopes; Strelow, Matheus Zschornack; Salama, Mohamed; Rao, Shilpa C.; Zewde, Yared Zenebe; Dindayal, Saiesha; Azar, Jihan; Prashanth, Lingappa Kukkle; Rajan, Roopa; Noyce, Alastair J.; Okubadejo, Njideka; Rizig, Mie; Lesage, Suzanne; Mata, Ignacio Fernandez; Global Parkinson's Genetics Program
Article

2021 4

Blood transcriptome analysis for Alzheimer' disease in Hong Kong Chinese population

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, v. 17, (S3), December 2021, article number e056643
Zhong, Huan; Zhou, Xiaopu; Jiang, Yuanbing; Chen, Yu; Lai, N.C.H.; Tong, Pui Sze; Lo, Ronnie M.N.; Kwok, Timonthy C.Y.; Mok, Vincent C.T.; Ip, Fanny Chui Fun; Mok, Kin Ying Boniface; Hardy, John; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese population

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, v. 17, (S3), December 2021, article number e056625
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Zhong, Huan; Chen, Yuewen; Chen, Jiahang; Zhang, Yulin; Ma, Shuangshuang; Lai, Nicole Chit Hang; Lo, Ronnie M.N.; Cheung, Kit; Tong, Pui Sze; Mok, Kin Ying Boniface; Hardy, John; Guo, Qihao; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

A high-performance biomarker panel for Alzheimer's disease screening and staging identified by large-scale plasma proteomic profiling

Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Chit Hang; Cheung, Kit; Lo, Ming Nok; Tong, Pui Sze; Wong, Wing Yan; Chan, Andrew L.T.; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Conference paper

A high-performance biomarker panel for Alzheimer's disease screening and staging identified by large-scale plasma proteomic profiling

The Journal of the Alzheimer’s Association, v. 17, (S5), December 2021, article number e056099, Supplement: Biomarkers – Part 2
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Chit Hang; Cheung, Kit; Lo, Ming Nok; Tong, Pui Sze; Wong, Wing Yan; Chan, Andrew L.T.; Mok, Vincent C.T.; Kwok, Timonthy C.Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

2020 4

Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome

JAMA Network Open, v. 3, (9), 28 September 2020, article number e2018221
D'Souza, Hana; Mason, Luke; Mok, Kin Ying Boniface; Startin, Carla M.; Hamburg, Sarah; Hithersay, Rosalyn; Baksh, R. Asaad; Hardy, John; Strydom, Andre; Thomas, Michael S.C.; London Down Syndrome (LonDownS), Consortium
Article

Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R

Neurobiology of Disease, v. 146, December 2020, article number 105079
Sandberg, Alexander; Ling, Helen; Gearing, Marla; Dombroski, Beth; Cantwell, Laura; R'Bibo, Lea; Levey, Allan; Schellenberg, Gerard.D.; Hardy, John; Wood, Nicholas; Fernius, Josefin; Nyström, Sofie; Svensson, Samuel; Thor, Stefan; Hammarström, Per; Revesz, Tamas; Mok, Kin Ying Boniface
Article

Fulminant Corticobasal Degeneration: A Distinct Variant With Predominant Neuronal Tau Aggregates

Acta Neuropathologica, v. 139, (4), April 2020, p. 717-734
Mok, Kin Ying Boniface
Article

Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, v. 12, (1), August 2020, article number e12074
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Lai, Nicole C.H.; Li, Yuen Tung; Jiang, Yuanbing; Zhong, Huan; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronie M.N.; Cheung, Kit; Tong, Pui Sze; Ko, Ho; Shoai, Maryam; Mok, Kin Ying Boniface; Hardy, John; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

2019 7

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

JAMA Neurology, v. 76, (2), February 2019, p. 152-160
Hithersay, Rosalyn; Startin, Carla M.; Hamburg, Sarah; Mok, Kin Ying Boniface; Hardy, John; Fisher, Elizabeth M. C.; Tybulewicz, Victor L. J.; Nizetic, Dean; Strydom, Andre
Article

C9orf72 Intermediate Repeats Are Associated With Corticobasal Degeneration, Increased C9orf72 Expression And Disruption Of Autophagy

Acta Neuropathologica, v. 138, (5), November 2019, p. 795-811
Cali, Christopher P.; Patino, Maribel; Tai, Yee Kit; Ho, Wan Yun; McLean, Catriona A.; Morris, Christopher M.; Seeley, William W.; Miller, Bruce L.; Gaig, Carles; Vonsattel, Jean Paul G.; White III, Charles L.; Roeber, Sigrun; Kretzschmar, Hans; Troncoso, Juan C.; Troakes, Claire; Gearing, Marla; Ghetti, Bernardino; Van Deerlin, Vivianna M.; Lee, Virginia Man Yee C.; Trojanowski, John Q.; Mok, Kin Ying Boniface; Ling, Helen; Dickson, Dennis W.; Schellenberg, Gerard D.; Ling, Shuo-Chien; Lee, Edward B.
Article

Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome

Alzheimer's & Dementia, v. 15, (2), February 2019, p. 245-257
Startin, Carla M.; Hamburg, Sarah; Hithersay, Rosalyn; Al-Janabi, Tamara; Mok, Kin Ying Boniface; Hardy, John; LonDownS Consortium; Strydom, Andre
Article

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Nature Communications, v. 10, (1), December 2019, article number 3310
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Guo, Qihao; Ip, Chui Fun Fanny; Chen, Yuewen; Mullapudi, Nandita; Giusti-Rodríguez, Paola; Sullivan, Patrick F.; Hardy,John; Fu, Kit Yu; Li, Yun; Ip, Nancy Yuk-yu
Article

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease

Alzheimer's Research and Therapy, v. 11, (1), March 2019, article number 26
Startin, Carla M.; Ashton, Nicholas J.; Hamburg, Sarah; Hithersay, Rosalyn; Wiseman, Frances K.; Mok, Kin Ying Boniface; Hardy, John; Lleo, Alberto; Lovestone, Simon; Parnetti, Lucilla; Zetterberg, Henrik; Hye, Abdul; Fisher, Elizabeth; Nizetic, Dean; Weston, Reta Lila; Tybulewicz, Victor; Karmiloff-Smith, Annette; Strydom, Andre; LonDownS, Consortium
Article

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, T.C.Y.; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Mullapudi, Nandita; Hardy, J.; Fu, Kit Yu; Li, Y.; Ip, Nancy Yuk-yu
Conference paper

Whole-genome sequencing for Alzheimer’s disease risk in the Chinese population

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Hardy, J.; Li, Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

2018 6

Aging related cognitive changes associated with Alzheimer's disease in Down syndrome

Annals of Clinical and Translational Neurology, v. 5, (6), June 2018, p. 741-751
Firth, Nicholas C.; Startin, Carla M.; Hithersay, Rosalyn; Hamburg, Sarah; Wijeratne, Peter A.; Mok, Kin Ying Boniface; Hardy, John; Alexander, Daniel C.; Strydom, Andre; LonDownS, Consortium
Article

Analysis of shared heritability in common disorders of the brain

Science, v. 360, (6395), June 2018, article number 8757
Mok, Kin Ying Boniface
Article

Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease

JAMA Neurology, v. 75, (11), November 2018, p. 1416-1422
COURAGE-PD Consortium; French Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium (IPDGC); Mok, Kin Ying Boniface
Article

Identification of Genetic Risk Factors in The Chinese Population Implicates a Role of the Immune System in Alzheimer’s Disease Pathogenesis

Proceedings of the National Academy of Sciences of the United States of America, v. 115, (8), February 2018, p. 1697-1706
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Zhao, Qianhua; Chen, Keliang; Chen, Yuewen; Hardy, John; Li, Yun; Fu, Kit Yu; Guo, Qihao; Ip, Nancy Yuk-yu
Article

Neurofilament Light as a Blood Biomarker for Neurodegeneration in Down Syndrome

Alzheimer's Research and Therapy, v. 10, (1), April 2018, article number 39
Strydom, André; Heslegrave, Amanda J.; Startin, C. M.; Mok, Kin Ying Boniface; Hardy, John A.; Groet, Jürgen; Nižetić, Dean; Zetterberg, Henrik; Fisher, Elizabeth M.C.; Tybulewicz, Victor L Lj J.; Karmiloff-Smith, Annette D.; Hamburg, Sarah; Hithersay, Rosalyn
Article

Response to the commentary of Yates RL and DeLuca GC on the study: HLA-DRB1^*}1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Multiple Sclerosis and Related Disorders, v.19, January 2018, p. 168-170
Yaldizli, Ozgur; Sethi, Varun; Pardini, Matteo; Tur, Carmen; Mok, Kin Ying Boniface; Muhlert, Nils; Liu, Zheng; Samson, Rebecca S.; Wheeler-Kingshott, Claudia A. M.; Yousry, Tarek A.; Houlden, Henry; Hardy, John; Miller, David H.; Chard, Declan T.
Article

2016 3

Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data

The Lancet Neurology, v. 15, (6), May 2016, p. 585-596
Mok, Kin Ying Boniface
Article

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Multiple Sclerosis and Related Disorders, v. 7, May 2016, p. 47-52
Yaldizli, Özgür; Sethi, Varun; Pardini, Matteo; Tur, Carmen; Mok, Kin Ying Boniface; Muhlert, Nils; Liu, Zheng; Samson, Rebecca S.; Wheeler-Kingshott, Claudia A. M.; Yousry, Tarek A; Houlden, Henry; Hardy, John; Miller, David H.; Chard, Declan T.
Article

Parkinson's disease without nigral degeneration: A pathological correlate of scans without evidence of dopaminergic deficit (SWEDD)?

Journal of Neurology, Neurosurgery and Psychiatry, v. 87, (6), June 2016, p. 633-641
Ling, Helen; Kearney, Seamus; Yip, Helen Lai Kuen; Silveira-Moriyama, Laura; Revesz, Tamas; Holton, Janice L.; Strand, Catherine; Davey, Karen; Mok, Kin Ying Boniface; Polke, James M.; Lees, Andrew J.
Article

Article 1

Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease

Alzheimer's and Dementia, v. 21, (1), January 2025, article number e14214
Zhou, Xiaopu; Cao, Han; Jiang, Yuanbing; Chen, Yuewen; Zhong, Huan; Fu, Wing Yu; Lo, Ronnie Ming Nok; Wong, Bonnie Wing Yan; Cheng, Elaine Yee Ling; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Ip, Fanny C. F.; Miyashita, Akinori; Hara, Norikazu; Ikeuchi, Takeshi; Hardy, John; Chen, Yu; Fu, Amy K. Y.; Ip, Nancy Yuk-yu

Article 2

A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups

Alzheimer's and Dementia, v. 20, (3), January 2024, p. 2000-2015
Jiang, Yuanbing; Uhm, Hyebin; Ip, Fanny C.; Ouyang, Li; Lo, Ronnie M. N.; Cheng, Elaine Y. L.; Cao, Xiaoyun; Tan, Clara M. C.; Law, Brian C. H.; Ortiz-Romero, Paula; Puig-Pijoan, Albert; Fernández-Lebrero, Aida; Contador, José; Mok, Kin Ying Boniface; Hardy, John; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Suárez-Calvet, Marc; Zetterberg, Henrik; Fu, Amy K. Y.; Ip, Nancy Yuk-yu

Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification

Alzheimers & Dementia, v. 20, (4), April 2024, p. 2469-2484
Zhong, Huan; Zhou, Xiaopu; Uhm, Hyebin; Jiang, Yuanbing; Cao, Han; Chen, Yu; Mak, Tiffany T. W.; Lo, Ronnie Ming Nok; Wong, Bonnie Wing Yan; Cheng, Elaine Yee Ling; Mok, Kin Ying Boniface; Chan, Andrew Lung Tat; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Ip, Fanny Chui Fun; Hardy, John; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu

Article 1

Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Communications Medicine, v. 3, April 2023, article number 49
Alzheimer’s Disease Neuroimaging Initiative; Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Lv, Ge; Zhang, Huan; Chen, Jiahang; Ye, Tao; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronnie M.N.; Tong, Pui Sze; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Guo, Qihao; Mok, Kin Ying Boniface; Shoai, Maryam; Hardy, John; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-yu

Article 3

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Nature Aging, v. 2, (7), July 2022, p. 616-634
Jiang, Yuanbing; Zhou, Xiaopu; Wong, Hiu Yi; Ouyang, Li; Ip, Fanny Chui Fun; Chau, Man Ni; Lau, Shun Fat; Wu, Wei; Wong, Yew Kit Daniel; Seo, Heukjin; Fu, Wing Yu; Lai, Chit Hang; Chen, Yuewen; Chen, Yu; Tong, Pui Sze; Alzheimer’s Disease Neuroimaging Initiative; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Ying Boniface; Shoai, Maryam; Lehallier, Benoit; Losada, Patricia Moran; O'Brien, Eleanor; Porter, Tenielle; Laws, Simon M.; Hardy, John; Wyss-Coray, Tony; Masters, Colin L.; Fu, Kit Yu; Ip, Nancy Yuk-Yu

Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging

Alzheimer's & Dementia, v. 18, (1), January 2022, p. 88-102
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Nicole C. H.; Cheung, Kit; Lo, Ronnie M. N.; Tong, Pui Sze; Wong, Bonnie W. Y.; Chan, Andrew L. T.; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu

Underrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future Directions

Movement Disorders, v. 37, (8), August 2022, p. 1593-1604
Schumacher-Schuh, Artur Francisco; Bieger, Andrei; Okunoye, Olaitan; Mok, Kin Ying Boniface; Lim, Shen-Yang; Bardien, Soraya; Ahmad-Annuar, Azlina; Santos-Lobato, Bruno Lopes; Strelow, Matheus Zschornack; Salama, Mohamed; Rao, Shilpa C.; Zewde, Yared Zenebe; Dindayal, Saiesha; Azar, Jihan; Prashanth, Lingappa Kukkle; Rajan, Roopa; Noyce, Alastair J.; Okubadejo, Njideka; Rizig, Mie; Lesage, Suzanne; Mata, Ignacio Fernandez; Global Parkinson's Genetics Program

Article 2

Blood transcriptome analysis for Alzheimer' disease in Hong Kong Chinese population

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, v. 17, (S3), December 2021, article number e056643
Zhong, Huan; Zhou, Xiaopu; Jiang, Yuanbing; Chen, Yu; Lai, N.C.H.; Tong, Pui Sze; Lo, Ronnie M.N.; Kwok, Timonthy C.Y.; Mok, Vincent C.T.; Ip, Fanny Chui Fun; Mok, Kin Ying Boniface; Hardy, John; Fu, Kit Yu; Ip, Nancy Yuk-yu

Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese population

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, v. 17, (S3), December 2021, article number e056625
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Zhong, Huan; Chen, Yuewen; Chen, Jiahang; Zhang, Yulin; Ma, Shuangshuang; Lai, Nicole Chit Hang; Lo, Ronnie M.N.; Cheung, Kit; Tong, Pui Sze; Mok, Kin Ying Boniface; Hardy, John; Guo, Qihao; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-yu

Conference paper 2

A high-performance biomarker panel for Alzheimer's disease screening and staging identified by large-scale plasma proteomic profiling

Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Chit Hang; Cheung, Kit; Lo, Ming Nok; Tong, Pui Sze; Wong, Wing Yan; Chan, Andrew L.T.; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-Yu

A high-performance biomarker panel for Alzheimer's disease screening and staging identified by large-scale plasma proteomic profiling

The Journal of the Alzheimer’s Association, v. 17, (S5), December 2021, article number e056099, Supplement: Biomarkers – Part 2
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Chit Hang; Cheung, Kit; Lo, Ming Nok; Tong, Pui Sze; Wong, Wing Yan; Chan, Andrew L.T.; Mok, Vincent C.T.; Kwok, Timonthy C.Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu

Article 4

Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome

JAMA Network Open, v. 3, (9), 28 September 2020, article number e2018221
D'Souza, Hana; Mason, Luke; Mok, Kin Ying Boniface; Startin, Carla M.; Hamburg, Sarah; Hithersay, Rosalyn; Baksh, R. Asaad; Hardy, John; Strydom, Andre; Thomas, Michael S.C.; London Down Syndrome (LonDownS), Consortium

Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R

Neurobiology of Disease, v. 146, December 2020, article number 105079
Sandberg, Alexander; Ling, Helen; Gearing, Marla; Dombroski, Beth; Cantwell, Laura; R'Bibo, Lea; Levey, Allan; Schellenberg, Gerard.D.; Hardy, John; Wood, Nicholas; Fernius, Josefin; Nyström, Sofie; Svensson, Samuel; Thor, Stefan; Hammarström, Per; Revesz, Tamas; Mok, Kin Ying Boniface

Fulminant Corticobasal Degeneration: A Distinct Variant With Predominant Neuronal Tau Aggregates

Acta Neuropathologica, v. 139, (4), April 2020, p. 717-734
Mok, Kin Ying Boniface

Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, v. 12, (1), August 2020, article number e12074
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Lai, Nicole C.H.; Li, Yuen Tung; Jiang, Yuanbing; Zhong, Huan; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronie M.N.; Cheung, Kit; Tong, Pui Sze; Ko, Ho; Shoai, Maryam; Mok, Kin Ying Boniface; Hardy, John; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu

Article 5

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

JAMA Neurology, v. 76, (2), February 2019, p. 152-160
Hithersay, Rosalyn; Startin, Carla M.; Hamburg, Sarah; Mok, Kin Ying Boniface; Hardy, John; Fisher, Elizabeth M. C.; Tybulewicz, Victor L. J.; Nizetic, Dean; Strydom, Andre

C9orf72 Intermediate Repeats Are Associated With Corticobasal Degeneration, Increased C9orf72 Expression And Disruption Of Autophagy

Acta Neuropathologica, v. 138, (5), November 2019, p. 795-811
Cali, Christopher P.; Patino, Maribel; Tai, Yee Kit; Ho, Wan Yun; McLean, Catriona A.; Morris, Christopher M.; Seeley, William W.; Miller, Bruce L.; Gaig, Carles; Vonsattel, Jean Paul G.; White III, Charles L.; Roeber, Sigrun; Kretzschmar, Hans; Troncoso, Juan C.; Troakes, Claire; Gearing, Marla; Ghetti, Bernardino; Van Deerlin, Vivianna M.; Lee, Virginia Man Yee C.; Trojanowski, John Q.; Mok, Kin Ying Boniface; Ling, Helen; Dickson, Dennis W.; Schellenberg, Gerard D.; Ling, Shuo-Chien; Lee, Edward B.

Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome

Alzheimer's & Dementia, v. 15, (2), February 2019, p. 245-257
Startin, Carla M.; Hamburg, Sarah; Hithersay, Rosalyn; Al-Janabi, Tamara; Mok, Kin Ying Boniface; Hardy, John; LonDownS Consortium; Strydom, Andre

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Nature Communications, v. 10, (1), December 2019, article number 3310
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Guo, Qihao; Ip, Chui Fun Fanny; Chen, Yuewen; Mullapudi, Nandita; Giusti-Rodríguez, Paola; Sullivan, Patrick F.; Hardy,John; Fu, Kit Yu; Li, Yun; Ip, Nancy Yuk-yu

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease

Alzheimer's Research and Therapy, v. 11, (1), March 2019, article number 26
Startin, Carla M.; Ashton, Nicholas J.; Hamburg, Sarah; Hithersay, Rosalyn; Wiseman, Frances K.; Mok, Kin Ying Boniface; Hardy, John; Lleo, Alberto; Lovestone, Simon; Parnetti, Lucilla; Zetterberg, Henrik; Hye, Abdul; Fisher, Elizabeth; Nizetic, Dean; Weston, Reta Lila; Tybulewicz, Victor; Karmiloff-Smith, Annette; Strydom, Andre; LonDownS, Consortium

Conference paper 2

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, T.C.Y.; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Mullapudi, Nandita; Hardy, J.; Fu, Kit Yu; Li, Y.; Ip, Nancy Yuk-yu

Whole-genome sequencing for Alzheimer’s disease risk in the Chinese population

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Hardy, J.; Li, Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu

Article 6

Aging related cognitive changes associated with Alzheimer's disease in Down syndrome

Annals of Clinical and Translational Neurology, v. 5, (6), June 2018, p. 741-751
Firth, Nicholas C.; Startin, Carla M.; Hithersay, Rosalyn; Hamburg, Sarah; Wijeratne, Peter A.; Mok, Kin Ying Boniface; Hardy, John; Alexander, Daniel C.; Strydom, Andre; LonDownS, Consortium

Analysis of shared heritability in common disorders of the brain

Science, v. 360, (6395), June 2018, article number 8757
Mok, Kin Ying Boniface

Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease

JAMA Neurology, v. 75, (11), November 2018, p. 1416-1422
COURAGE-PD Consortium; French Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium (IPDGC); Mok, Kin Ying Boniface

Identification of Genetic Risk Factors in The Chinese Population Implicates a Role of the Immune System in Alzheimer’s Disease Pathogenesis

Proceedings of the National Academy of Sciences of the United States of America, v. 115, (8), February 2018, p. 1697-1706
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Zhao, Qianhua; Chen, Keliang; Chen, Yuewen; Hardy, John; Li, Yun; Fu, Kit Yu; Guo, Qihao; Ip, Nancy Yuk-yu

Neurofilament Light as a Blood Biomarker for Neurodegeneration in Down Syndrome

Alzheimer's Research and Therapy, v. 10, (1), April 2018, article number 39
Strydom, André; Heslegrave, Amanda J.; Startin, C. M.; Mok, Kin Ying Boniface; Hardy, John A.; Groet, Jürgen; Nižetić, Dean; Zetterberg, Henrik; Fisher, Elizabeth M.C.; Tybulewicz, Victor L Lj J.; Karmiloff-Smith, Annette D.; Hamburg, Sarah; Hithersay, Rosalyn

Response to the commentary of Yates RL and DeLuca GC on the study: HLA-DRB1^*}1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Multiple Sclerosis and Related Disorders, v.19, January 2018, p. 168-170
Yaldizli, Ozgur; Sethi, Varun; Pardini, Matteo; Tur, Carmen; Mok, Kin Ying Boniface; Muhlert, Nils; Liu, Zheng; Samson, Rebecca S.; Wheeler-Kingshott, Claudia A. M.; Yousry, Tarek A.; Houlden, Henry; Hardy, John; Miller, David H.; Chard, Declan T.

Article 3

Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data

The Lancet Neurology, v. 15, (6), May 2016, p. 585-596
Mok, Kin Ying Boniface

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Multiple Sclerosis and Related Disorders, v. 7, May 2016, p. 47-52
Yaldizli, Özgür; Sethi, Varun; Pardini, Matteo; Tur, Carmen; Mok, Kin Ying Boniface; Muhlert, Nils; Liu, Zheng; Samson, Rebecca S.; Wheeler-Kingshott, Claudia A. M.; Yousry, Tarek A; Houlden, Henry; Hardy, John; Miller, David H.; Chard, Declan T.

Parkinson's disease without nigral degeneration: A pathological correlate of scans without evidence of dopaminergic deficit (SWEDD)?

Journal of Neurology, Neurosurgery and Psychiatry, v. 87, (6), June 2016, p. 633-641
Ling, Helen; Kearney, Seamus; Yip, Helen Lai Kuen; Silveira-Moriyama, Laura; Revesz, Tamas; Holton, Janice L.; Strand, Catherine; Davey, Karen; Mok, Kin Ying Boniface; Polke, James M.; Lees, Andrew J.

2019 7

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

JAMA Neurology, v. 76, (2), February 2019, p. 152-160
Hithersay, Rosalyn; Startin, Carla M.; Hamburg, Sarah; Mok, Kin Ying Boniface; Hardy, John; Fisher, Elizabeth M. C.; Tybulewicz, Victor L. J.; Nizetic, Dean; Strydom, Andre
Article

C9orf72 Intermediate Repeats Are Associated With Corticobasal Degeneration, Increased C9orf72 Expression And Disruption Of Autophagy

Acta Neuropathologica, v. 138, (5), November 2019, p. 795-811
Cali, Christopher P.; Patino, Maribel; Tai, Yee Kit; Ho, Wan Yun; McLean, Catriona A.; Morris, Christopher M.; Seeley, William W.; Miller, Bruce L.; Gaig, Carles; Vonsattel, Jean Paul G.; White III, Charles L.; Roeber, Sigrun; Kretzschmar, Hans; Troncoso, Juan C.; Troakes, Claire; Gearing, Marla; Ghetti, Bernardino; Van Deerlin, Vivianna M.; Lee, Virginia Man Yee C.; Trojanowski, John Q.; Mok, Kin Ying Boniface; Ling, Helen; Dickson, Dennis W.; Schellenberg, Gerard D.; Ling, Shuo-Chien; Lee, Edward B.
Article

Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome

Alzheimer's & Dementia, v. 15, (2), February 2019, p. 245-257
Startin, Carla M.; Hamburg, Sarah; Hithersay, Rosalyn; Al-Janabi, Tamara; Mok, Kin Ying Boniface; Hardy, John; LonDownS Consortium; Strydom, Andre
Article

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Nature Communications, v. 10, (1), December 2019, article number 3310
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Guo, Qihao; Ip, Chui Fun Fanny; Chen, Yuewen; Mullapudi, Nandita; Giusti-Rodríguez, Paola; Sullivan, Patrick F.; Hardy,John; Fu, Kit Yu; Li, Yun; Ip, Nancy Yuk-yu
Article

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease

Alzheimer's Research and Therapy, v. 11, (1), March 2019, article number 26
Startin, Carla M.; Ashton, Nicholas J.; Hamburg, Sarah; Hithersay, Rosalyn; Wiseman, Frances K.; Mok, Kin Ying Boniface; Hardy, John; Lleo, Alberto; Lovestone, Simon; Parnetti, Lucilla; Zetterberg, Henrik; Hye, Abdul; Fisher, Elizabeth; Nizetic, Dean; Weston, Reta Lila; Tybulewicz, Victor; Karmiloff-Smith, Annette; Strydom, Andre; LonDownS, Consortium
Article

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, T.C.Y.; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Mullapudi, Nandita; Hardy, J.; Fu, Kit Yu; Li, Y.; Ip, Nancy Yuk-yu
Conference paper

Whole-genome sequencing for Alzheimer’s disease risk in the Chinese population

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Hardy, J.; Li, Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

2018 6

Aging related cognitive changes associated with Alzheimer's disease in Down syndrome

Annals of Clinical and Translational Neurology, v. 5, (6), June 2018, p. 741-751
Firth, Nicholas C.; Startin, Carla M.; Hithersay, Rosalyn; Hamburg, Sarah; Wijeratne, Peter A.; Mok, Kin Ying Boniface; Hardy, John; Alexander, Daniel C.; Strydom, Andre; LonDownS, Consortium
Article

Analysis of shared heritability in common disorders of the brain

Science, v. 360, (6395), June 2018, article number 8757
Mok, Kin Ying Boniface
Article

Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease

JAMA Neurology, v. 75, (11), November 2018, p. 1416-1422
COURAGE-PD Consortium; French Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium (IPDGC); Mok, Kin Ying Boniface
Article

Identification of Genetic Risk Factors in The Chinese Population Implicates a Role of the Immune System in Alzheimer’s Disease Pathogenesis

Proceedings of the National Academy of Sciences of the United States of America, v. 115, (8), February 2018, p. 1697-1706
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Zhao, Qianhua; Chen, Keliang; Chen, Yuewen; Hardy, John; Li, Yun; Fu, Kit Yu; Guo, Qihao; Ip, Nancy Yuk-yu
Article

Neurofilament Light as a Blood Biomarker for Neurodegeneration in Down Syndrome

Alzheimer's Research and Therapy, v. 10, (1), April 2018, article number 39
Strydom, André; Heslegrave, Amanda J.; Startin, C. M.; Mok, Kin Ying Boniface; Hardy, John A.; Groet, Jürgen; Nižetić, Dean; Zetterberg, Henrik; Fisher, Elizabeth M.C.; Tybulewicz, Victor L Lj J.; Karmiloff-Smith, Annette D.; Hamburg, Sarah; Hithersay, Rosalyn
Article

Response to the commentary of Yates RL and DeLuca GC on the study: HLA-DRB1^*}1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Multiple Sclerosis and Related Disorders, v.19, January 2018, p. 168-170
Yaldizli, Ozgur; Sethi, Varun; Pardini, Matteo; Tur, Carmen; Mok, Kin Ying Boniface; Muhlert, Nils; Liu, Zheng; Samson, Rebecca S.; Wheeler-Kingshott, Claudia A. M.; Yousry, Tarek A.; Houlden, Henry; Hardy, John; Miller, David H.; Chard, Declan T.
Article

2016 3

Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data

The Lancet Neurology, v. 15, (6), May 2016, p. 585-596
Mok, Kin Ying Boniface
Article

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Multiple Sclerosis and Related Disorders, v. 7, May 2016, p. 47-52
Yaldizli, Özgür; Sethi, Varun; Pardini, Matteo; Tur, Carmen; Mok, Kin Ying Boniface; Muhlert, Nils; Liu, Zheng; Samson, Rebecca S.; Wheeler-Kingshott, Claudia A. M.; Yousry, Tarek A; Houlden, Henry; Hardy, John; Miller, David H.; Chard, Declan T.
Article

Parkinson's disease without nigral degeneration: A pathological correlate of scans without evidence of dopaminergic deficit (SWEDD)?

Journal of Neurology, Neurosurgery and Psychiatry, v. 87, (6), June 2016, p. 633-641
Ling, Helen; Kearney, Seamus; Yip, Helen Lai Kuen; Silveira-Moriyama, Laura; Revesz, Tamas; Holton, Janice L.; Strand, Catherine; Davey, Karen; Mok, Kin Ying Boniface; Polke, James M.; Lees, Andrew J.
Article

Projects

From January 2023 to December 2025

No Projects.
Comprehensive database of Alzheimer's disease for Han Chinese in Hong Kong

「阿茲海默氏癥」神經退化疾病研究 Participating

Chow Tai Fook Charity Foundation Limited
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

FU Amy Kit Yu

MOK Kin Ying Boniface
2017 -

Research Interest

Publications

2025 1

2024 2

2023 1

2022 3

2021 4

2020 4

2019 7

2018 6

2016 3

Article 1

Article 2

Article 1

Article 3

Article 2

Conference paper 2

Article 4

Article 5

Conference paper 2

Article 6

Article 3

2019 7

2018 6

2016 3

Projects

From January 2023 to December 2025

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