Faculty Profiles - CHUNG Kenny K | The Hong Kong University of Science and Technology

Kenny K CHUNG
鍾家健

PhD in Neuroscience
University of Cambridge, 2001

Associate Professor
Division of Life Science

Program Director of BSc in Biotechnology and Business

(852) 2358 8019
bckchung@ust.hk
Room 5439
Personal Web

ORCID

0000-0002-4002-1338

Scopus ID

23970042200

Research Interest Publications Projects Teaching Assignment RPG Supervision Space used

Research Interest

Molecular mechanisms of neurodegeneration

Publications

All Years 43 2024 1 2023 0 2022 0 2021 0 2020 1 2019 0 2018 41

2024 1

The role of age-associated alpha-synuclein aggregation in a conditional transgenic mouse model of Parkinson's disease: Implications for Lewy body formation

Journal of Neurochemistry, v. 168, (7), July 2024, p. 1215-1236
Li, Jiahua; Ng, Ka Wai; Sung, Chun Chau; Chung, Ka Kin Kenny
Article

2020 1

S-Nitrosylation of G Protein-Coupled Receptor Kinase 6 and Casein Kinase 2 Alpha Modulates Their Kinase Activity Toward Alpha-Synuclein Phosphorylation in an Animal Model of Parkinson's Disease

PLoS ONE, v. 15, (4), 28 April 2020, article number e.0232019
Wu, Weiwei; Sung, Chun Chau; Yu, Peichun; Li, Jiahua; Chung, Kenny K
Article

2018 1

PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.

Proceedings of the National Academy of Sciences of the United States of America, v. 115, (30), July 2018, p. E7193-E7201
He, Jing; Xia, Mengying; Yeung, Patrick K. K.; Li, Jiahua; Li, Zhifang; Chung, Ka Kin Kenny; Chung, Sookja K; Xia, Jun
Article

2017 2

Novel Enhancement Mechanism of Tyrosine Hydroxylase Enzymatic Activity by Nitric Oxide through S-nitrosylation

Scientific Reports, v. 7, March 2017, article number 44154
Wang, Yuanyuan; Sung, Chunchau; Chung, Kenny K K
Article

The role of nitric oxide signaling in the pathogenesis of Parkinson's disease

Wu, Weiwei; Wang, Yuanyuan; Chung, Kenny K
Conference paper

2015 2

S-nitrosylation of XIAP at Cys 213 of BIR2 Domain Impairs XIAP's Anti-caspase 3 Activity and Anti-apoptotic Function

Apoptosis, v. 20, (4), 2015, p. 491-499
Wu, Weiwei; Wan, Oi Wan; Chung, Kenny Ka Kin
Article

Studying Nitrosative Stress in Parkinson’s Disease

Stress Responses / Editors: Christine M. Oslowski. New York : Humana Press, New York, NY, 2015, p. 195-201, Series: Methods in Molecular Biology
Chung, Kenny K K
Book chapter

2012 2

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease

Journal of neurochemistry, v. 122, (2), July 2012, p. 404-414
Xie, Weilin; Chung, Kenny K.K.
Article

The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson's Disease

PLoS ONE, v. 7, (6), June 2012
Wan, Oi Wan; Chung, Kenny K.K.
Article

2011 4

P32 regulates mitochondrial morphology and dynamics through parkin

Neuroscience, v. 199, 2011, p. 346-358
Li, Youjun; Wan, Oi Wan; Xie, W.; Chung, Kenny K.K.
Article

Involvement of S-nitrosylation in neurodegeneration

Post-translational modifications in health and disease / Edited by Cecilio J. Vidal. New York : Springer, 2011, p. 79-95
Chung, Kenny K.K.; Li, Y.
Book chapter

S-Nitrosylation of Cdk5 Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development

Zhang, P.; Yu,P-C; Tsang, A.H.; Chen, Y.; Fu, Kit Yu; Fu, WY; Chung, Kenny Ka Kin; Ip, Nancy Yuk-Yu
Conference paper

The role of alpha-synuclein aggregation in Parkinson's disease

13th International Neuroscience Winter Conference, Sölden Austria, 2011
Wan, Oi Wan; Chung, Kenny
Conference paper

2010 5

Emerging roles of nitric oxide in neurodegeneration

Nitric oxide-biology and CHEMISTRY, v. 22, (4), 2010, MAY 15, p. 290-295
Chung, Kenny K.K.; David, Karen K.
Article

Modulation of pro-survival proteins by S-nitrosylation: implications for neurodegeneration

Apoptosis, v. 15, (11), Nov 2010, p. 1364-1370
Chung, Kenny KK
Article

New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease

BIOCHIMICA ET BIOPHYSICA acta-molecular Basis OF Disease, v. 1802, (11), 2010, NOV, p. 935-941
Xie, Weilin; Wan, Oi Wan; Chung, Kenny K.K.
Article

S-Nitrosylation of Cyclin-Dependent Kinase 5 (Cdk5) Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development

Journal of Neuroscience, v. 30, (43), October 2010, p. 14366-14370
Zhang, Peng; Yu, Peichun; Tsang, Anthony H.K.; Chen, Yu; Fu, Kit Yu; Fu, Wing Yu; Chung, Kenny K.K.; Ip, Nancy Yuk-Yu
Article

Regulation of Cyclin-Dependent Kinase-5 Activity by S-Nitrosylation

Fu, Wing Yu; Zhang, Peng; Tsang, Anthony H.K.; Xie, S.Y.; Fu, Kit Yu; Chung, Kenny K K; Ip, Nancy Yuk-Yu
Conference paper

2009 4

Oxidative stress and nitrosative stress in Parkinson's disease

Biochim Biophys Acta., 1792, 643-650
Tsang, Anthony H.K.; Chung, Kenny K.K.
Article

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

Proceedings of the National Academy of Sciences of the United States of America, v. 106, (12), 2009, MAR 24, p. 4900-4905
Tsang, Anthony H.K.; Lee, Yun-Il; Ko, Han Seok; Savitt, Joseph M.; Pletnikova, Olga; Troncoso, Juan C.; Dawson, Valina L.; Dawson, Ted M.; Chung, Kenny K.K.
Article

The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease

Journal of neurochemistry, v. 110, (1), 2009, JUL, p. 208-219
Lee, F.K.M.; Wong, A.K.Y.; Lee, Y.W.; Wan, Oi Wan; Chan, H.Y.E.; Chung, Kenny K.K.
Article

Characterization of p32 as an interactor of parkin

Society for Neuroscience, Chicago
Li, Yihang; Chung, Kenny K.K.
Conference paper

2008 3

Modification of X-linked Inhibitor of Apoptosis Protein by Nitric Oxide

38th Annual Meeting, Society for Neuroscience, Washington DC, 15-19 Nov 2008
Tsang, Anthony H.K.; Chung, Kenny K.K.
Conference paper

S-nitrosylation of x-linked inhibitor of apoptosis protein (xIAP): Implication to the pathogenesis of Parkinson's disease (PD)

Gordon Research Conference, Molecular and Cellular Neurobiology, 8-13/June/2008
Tsang, Anthony; Chung, Kenny
Conference paper

The role of alpha-synuclein aggregation in the pathogenesis of Parkinson's disease

Gordon Research Conference, Molecular and cellular neurobiology, 8-13/June/2008
Wan, Oi Wan; Chung, Kenny K.K.
Conference paper

2007 1

Gaseous Signaling: Nitric Oxide and Carbon Monoxide as Messenger Molecules

Handbook of Contemporary Neuropharmacology / Editor David Robert Sibley. Hoboken, N.J. : John Wiley & Sons, 2007
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.
Book chapter

2006 2

Say NO to neurodegeneration: Role of S-nitrosylation in neurodegenerative disorders

NeuroSignals, v. 15, (6), 2006, p. 307-313
Chung, Kenny K.K.
Article

Functional study of parkin: insights into the pathogenesis of Parkinson's disease

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, The Hong Kong Society of Neuroscience, Hong Kong, Symposium VI
Chung, Kenny K.
Conference paper

2005 5

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

Journal of Neuroscience, 25: 7968-7978
Ko, Han S.; Coelln, Rainer V.; Sriram, Sathya R.; Kim, Seong W.; Chung, Kenny K.K.; Pletnikova, Olga; Troncoso, Juan; Johnson, Brett; Saffary, Roya; Goh, Eyleen L.; Song, Hongjun; Park, Bum-Joon; Kim, Min J.; Kim, Sunghoon; Dawson, Valina L.; Dawson, Ted M.
Article

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

Human Molecular Genetics, 14: 2571-2586
Sriram, Sathya R.; Li, Xiaojie; Ko, Han S.; Chung, Kenny K.K.; Wong, Esther; Lim, Kah L.; Dawson, Valina L.; Dawson, Ted M.
Article

Nitric oxide, S-nitrosylation and neurodegeneration.

Cellular and Molecular Biology, 51: 247-254
Chung, Kenny K.K.; Dawson, Ted M.; Dawson, Valina L.
Article

Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation

J. Neurosci., v. 25, 2005, p. 2002-2009
Lim, K.L.; Chew, K.C.M.; Tan, J.M.M.; Wang, C.; Chung, Kenny K.K.; Zhang, Y.; Tanaka, Y.; Wei, W.L.; Engelender, S.; Ross, C.A.; Dawson, V.L.; Dawson, T.M.
Article

S-nitrosylation in Parkinson's disease and related neurodegenerative disorders

Nitric Oxide, Part E / Edited by Lester Packer, and Enrique Cadenas. London : Academic Press, 2005, p. 139-150, Ch. 14. Book Series: Methods in Enzymology. v. 396
Chung, Kenny K.K.; Dawson, Valina L.; Dawson, Ted M.
Book chapter

2004 2

Parkin and HSP70 sacked by BAG5

Neuron 44, 2004, p. 899-901
Chung, Kenny K.K.; Dawson, T.M.
Article

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

Science, v. 304, (5675), 2004, p. 1328-1331
Chung, Kenny K.K.; Thomas, B.; Li, X.; Pletnikova, O.; Troncoso, J.C.; Marsh, L.; Dawson, V.L.; Dawson, T.M.
Article

2003 2

New insights into Parkinson's disease

J Neurol 250 Suppl 3, 2003, p. 15-24
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.
Article

SEPT5_v2 is a parkin-binding protein

Brain Res Mol Brain Res, v. 117, (2), 2003, p. 179-189
Choi, Peter; Snyder, Heather M.; Petrucelli, Leonard; Theisler, Catherine M.; Chong, Matthew; Zhang, Yongjie; Kah Leong, Lim; Chung, Kenny K.K.; Kehoe, Kathryn; D'Adamio, Luciano D.; Lee, John; Cochran, Elizabeth J.; Bowser, Robert P.; Dawson, Ted Murray; Wolozin, Benjamin L.
Article

2001 2

Parkin ubiquitinates the alpha-synuclein interacting protein, synphilin-1: implications for Lewy body formation in Parkinson"s disease

Nature Med., v. 7, (10), 2001, p. 1144-1150
Chung, Kenny K.K.; Zhang, Y.; Lim, K.L.; Tanaka, Y.; Huang, H.; Gao, J.; Ross, C.; Dawson, V.L.; Dawson, T.M.
Article

The role of the ubiquitin proteasomal pathway in Parkinson's Disease and other neurodegenerative disorders

TINS., v. 24, (11), 2001, p. S7-S14
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.
Article

2000 2

C-fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin

Neuroscience, v. 95, (2), 2000, p. 453-463
Chung, Kenny K.K.; Martinez, M.; Herbert,J
Article

Parkin functions as an E3-dependent ubiquitin-protein ligase and promotes the degradation of synaptic vesicle associated protein

CDCrel-1. Proc .Natl. Acad. Sci. USA, v. 97, (24), 2000, p. 13354-13359
Zhang, Y.; Gao, J.; Chung, Kenny K.K.; Huang, H.; Dawson, V.L.; Dawson, T.M.
Article

1999 1

Central serotonin depletion modulates the behavioural tendocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats

Neuroscience, v, 92, (2), 1999, p. 613-625.
Chung, Kenny K.K.; Martinez, M.; Herbert, J.
Article

1997 1

The antigenic sites of trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties

Life Sciences, v. 61, (23), 1997, p. 2291-2303
Mulot, S.; Chung, Kenny K.K.; Li, X.B.; Wong, C.C.; Ng, T.B.; Shaw, P.C.
Article

Article 1

The role of age-associated alpha-synuclein aggregation in a conditional transgenic mouse model of Parkinson's disease: Implications for Lewy body formation

Journal of Neurochemistry, v. 168, (7), July 2024, p. 1215-1236
Li, Jiahua; Ng, Ka Wai; Sung, Chun Chau; Chung, Ka Kin Kenny

Article 1

S-Nitrosylation of G Protein-Coupled Receptor Kinase 6 and Casein Kinase 2 Alpha Modulates Their Kinase Activity Toward Alpha-Synuclein Phosphorylation in an Animal Model of Parkinson's Disease

PLoS ONE, v. 15, (4), 28 April 2020, article number e.0232019
Wu, Weiwei; Sung, Chun Chau; Yu, Peichun; Li, Jiahua; Chung, Kenny K

Article 1

PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.

Proceedings of the National Academy of Sciences of the United States of America, v. 115, (30), July 2018, p. E7193-E7201
He, Jing; Xia, Mengying; Yeung, Patrick K. K.; Li, Jiahua; Li, Zhifang; Chung, Ka Kin Kenny; Chung, Sookja K; Xia, Jun

Article 1

Novel Enhancement Mechanism of Tyrosine Hydroxylase Enzymatic Activity by Nitric Oxide through S-nitrosylation

Scientific Reports, v. 7, March 2017, article number 44154
Wang, Yuanyuan; Sung, Chunchau; Chung, Kenny K K

Conference paper 1

The role of nitric oxide signaling in the pathogenesis of Parkinson's disease

Wu, Weiwei; Wang, Yuanyuan; Chung, Kenny K

Article 1

S-nitrosylation of XIAP at Cys 213 of BIR2 Domain Impairs XIAP's Anti-caspase 3 Activity and Anti-apoptotic Function

Apoptosis, v. 20, (4), 2015, p. 491-499
Wu, Weiwei; Wan, Oi Wan; Chung, Kenny Ka Kin

Book chapter 1

Studying Nitrosative Stress in Parkinson’s Disease

Stress Responses / Editors: Christine M. Oslowski. New York : Humana Press, New York, NY, 2015, p. 195-201, Series: Methods in Molecular Biology
Chung, Kenny K K

Article 2

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease

Journal of neurochemistry, v. 122, (2), July 2012, p. 404-414
Xie, Weilin; Chung, Kenny K.K.

The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson's Disease

PLoS ONE, v. 7, (6), June 2012
Wan, Oi Wan; Chung, Kenny K.K.

Article 1

P32 regulates mitochondrial morphology and dynamics through parkin

Neuroscience, v. 199, 2011, p. 346-358
Li, Youjun; Wan, Oi Wan; Xie, W.; Chung, Kenny K.K.

Book chapter 1

Involvement of S-nitrosylation in neurodegeneration

Post-translational modifications in health and disease / Edited by Cecilio J. Vidal. New York : Springer, 2011, p. 79-95
Chung, Kenny K.K.; Li, Y.

Conference paper 2

S-Nitrosylation of Cdk5 Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development

Zhang, P.; Yu,P-C; Tsang, A.H.; Chen, Y.; Fu, Kit Yu; Fu, WY; Chung, Kenny Ka Kin; Ip, Nancy Yuk-Yu

The role of alpha-synuclein aggregation in Parkinson's disease

13th International Neuroscience Winter Conference, Sölden Austria, 2011
Wan, Oi Wan; Chung, Kenny

Article 4

Emerging roles of nitric oxide in neurodegeneration

Nitric oxide-biology and CHEMISTRY, v. 22, (4), 2010, MAY 15, p. 290-295
Chung, Kenny K.K.; David, Karen K.

Modulation of pro-survival proteins by S-nitrosylation: implications for neurodegeneration

Apoptosis, v. 15, (11), Nov 2010, p. 1364-1370
Chung, Kenny KK

New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease

BIOCHIMICA ET BIOPHYSICA acta-molecular Basis OF Disease, v. 1802, (11), 2010, NOV, p. 935-941
Xie, Weilin; Wan, Oi Wan; Chung, Kenny K.K.

S-Nitrosylation of Cyclin-Dependent Kinase 5 (Cdk5) Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development

Journal of Neuroscience, v. 30, (43), October 2010, p. 14366-14370
Zhang, Peng; Yu, Peichun; Tsang, Anthony H.K.; Chen, Yu; Fu, Kit Yu; Fu, Wing Yu; Chung, Kenny K.K.; Ip, Nancy Yuk-Yu

Conference paper 1

Regulation of Cyclin-Dependent Kinase-5 Activity by S-Nitrosylation

Fu, Wing Yu; Zhang, Peng; Tsang, Anthony H.K.; Xie, S.Y.; Fu, Kit Yu; Chung, Kenny K K; Ip, Nancy Yuk-Yu

Article 3

Oxidative stress and nitrosative stress in Parkinson's disease

Biochim Biophys Acta., 1792, 643-650
Tsang, Anthony H.K.; Chung, Kenny K.K.

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

Proceedings of the National Academy of Sciences of the United States of America, v. 106, (12), 2009, MAR 24, p. 4900-4905
Tsang, Anthony H.K.; Lee, Yun-Il; Ko, Han Seok; Savitt, Joseph M.; Pletnikova, Olga; Troncoso, Juan C.; Dawson, Valina L.; Dawson, Ted M.; Chung, Kenny K.K.

The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease

Journal of neurochemistry, v. 110, (1), 2009, JUL, p. 208-219
Lee, F.K.M.; Wong, A.K.Y.; Lee, Y.W.; Wan, Oi Wan; Chan, H.Y.E.; Chung, Kenny K.K.

Conference paper 1

Characterization of p32 as an interactor of parkin

Society for Neuroscience, Chicago
Li, Yihang; Chung, Kenny K.K.

Conference paper 3

Modification of X-linked Inhibitor of Apoptosis Protein by Nitric Oxide

38th Annual Meeting, Society for Neuroscience, Washington DC, 15-19 Nov 2008
Tsang, Anthony H.K.; Chung, Kenny K.K.

S-nitrosylation of x-linked inhibitor of apoptosis protein (xIAP): Implication to the pathogenesis of Parkinson's disease (PD)

Gordon Research Conference, Molecular and Cellular Neurobiology, 8-13/June/2008
Tsang, Anthony; Chung, Kenny

The role of alpha-synuclein aggregation in the pathogenesis of Parkinson's disease

Gordon Research Conference, Molecular and cellular neurobiology, 8-13/June/2008
Wan, Oi Wan; Chung, Kenny K.K.

Book chapter 1

Gaseous Signaling: Nitric Oxide and Carbon Monoxide as Messenger Molecules

Handbook of Contemporary Neuropharmacology / Editor David Robert Sibley. Hoboken, N.J. : John Wiley & Sons, 2007
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.

Article 1

Say NO to neurodegeneration: Role of S-nitrosylation in neurodegenerative disorders

NeuroSignals, v. 15, (6), 2006, p. 307-313
Chung, Kenny K.K.

Conference paper 1

Functional study of parkin: insights into the pathogenesis of Parkinson's disease

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, The Hong Kong Society of Neuroscience, Hong Kong, Symposium VI
Chung, Kenny K.

Article 4

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

Journal of Neuroscience, 25: 7968-7978
Ko, Han S.; Coelln, Rainer V.; Sriram, Sathya R.; Kim, Seong W.; Chung, Kenny K.K.; Pletnikova, Olga; Troncoso, Juan; Johnson, Brett; Saffary, Roya; Goh, Eyleen L.; Song, Hongjun; Park, Bum-Joon; Kim, Min J.; Kim, Sunghoon; Dawson, Valina L.; Dawson, Ted M.

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

Human Molecular Genetics, 14: 2571-2586
Sriram, Sathya R.; Li, Xiaojie; Ko, Han S.; Chung, Kenny K.K.; Wong, Esther; Lim, Kah L.; Dawson, Valina L.; Dawson, Ted M.

Nitric oxide, S-nitrosylation and neurodegeneration.

Cellular and Molecular Biology, 51: 247-254
Chung, Kenny K.K.; Dawson, Ted M.; Dawson, Valina L.

Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation

J. Neurosci., v. 25, 2005, p. 2002-2009
Lim, K.L.; Chew, K.C.M.; Tan, J.M.M.; Wang, C.; Chung, Kenny K.K.; Zhang, Y.; Tanaka, Y.; Wei, W.L.; Engelender, S.; Ross, C.A.; Dawson, V.L.; Dawson, T.M.

Book chapter 1

S-nitrosylation in Parkinson's disease and related neurodegenerative disorders

Nitric Oxide, Part E / Edited by Lester Packer, and Enrique Cadenas. London : Academic Press, 2005, p. 139-150, Ch. 14. Book Series: Methods in Enzymology. v. 396
Chung, Kenny K.K.; Dawson, Valina L.; Dawson, Ted M.

Article 2

Parkin and HSP70 sacked by BAG5

Neuron 44, 2004, p. 899-901
Chung, Kenny K.K.; Dawson, T.M.

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

Science, v. 304, (5675), 2004, p. 1328-1331
Chung, Kenny K.K.; Thomas, B.; Li, X.; Pletnikova, O.; Troncoso, J.C.; Marsh, L.; Dawson, V.L.; Dawson, T.M.

Article 2

New insights into Parkinson's disease

J Neurol 250 Suppl 3, 2003, p. 15-24
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.

SEPT5_v2 is a parkin-binding protein

Brain Res Mol Brain Res, v. 117, (2), 2003, p. 179-189
Choi, Peter; Snyder, Heather M.; Petrucelli, Leonard; Theisler, Catherine M.; Chong, Matthew; Zhang, Yongjie; Kah Leong, Lim; Chung, Kenny K.K.; Kehoe, Kathryn; D'Adamio, Luciano D.; Lee, John; Cochran, Elizabeth J.; Bowser, Robert P.; Dawson, Ted Murray; Wolozin, Benjamin L.

Article 2

Parkin ubiquitinates the alpha-synuclein interacting protein, synphilin-1: implications for Lewy body formation in Parkinson"s disease

Nature Med., v. 7, (10), 2001, p. 1144-1150
Chung, Kenny K.K.; Zhang, Y.; Lim, K.L.; Tanaka, Y.; Huang, H.; Gao, J.; Ross, C.; Dawson, V.L.; Dawson, T.M.

The role of the ubiquitin proteasomal pathway in Parkinson's Disease and other neurodegenerative disorders

TINS., v. 24, (11), 2001, p. S7-S14
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.

Article 2

C-fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin

Neuroscience, v. 95, (2), 2000, p. 453-463
Chung, Kenny K.K.; Martinez, M.; Herbert,J

Parkin functions as an E3-dependent ubiquitin-protein ligase and promotes the degradation of synaptic vesicle associated protein

CDCrel-1. Proc .Natl. Acad. Sci. USA, v. 97, (24), 2000, p. 13354-13359
Zhang, Y.; Gao, J.; Chung, Kenny K.K.; Huang, H.; Dawson, V.L.; Dawson, T.M.

Article 1

Central serotonin depletion modulates the behavioural tendocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats

Neuroscience, v, 92, (2), 1999, p. 613-625.
Chung, Kenny K.K.; Martinez, M.; Herbert, J.

Article 1

The antigenic sites of trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties

Life Sciences, v. 61, (23), 1997, p. 2291-2303
Mulot, S.; Chung, Kenny K.K.; Li, X.B.; Wong, C.C.; Ng, T.B.; Shaw, P.C.

2018 1

PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.

Proceedings of the National Academy of Sciences of the United States of America, v. 115, (30), July 2018, p. E7193-E7201
He, Jing; Xia, Mengying; Yeung, Patrick K. K.; Li, Jiahua; Li, Zhifang; Chung, Ka Kin Kenny; Chung, Sookja K; Xia, Jun
Article

2017 2

Novel Enhancement Mechanism of Tyrosine Hydroxylase Enzymatic Activity by Nitric Oxide through S-nitrosylation

Scientific Reports, v. 7, March 2017, article number 44154
Wang, Yuanyuan; Sung, Chunchau; Chung, Kenny K K
Article

The role of nitric oxide signaling in the pathogenesis of Parkinson's disease

Wu, Weiwei; Wang, Yuanyuan; Chung, Kenny K
Conference paper

2015 2

S-nitrosylation of XIAP at Cys 213 of BIR2 Domain Impairs XIAP's Anti-caspase 3 Activity and Anti-apoptotic Function

Apoptosis, v. 20, (4), 2015, p. 491-499
Wu, Weiwei; Wan, Oi Wan; Chung, Kenny Ka Kin
Article

Studying Nitrosative Stress in Parkinson’s Disease

Stress Responses / Editors: Christine M. Oslowski. New York : Humana Press, New York, NY, 2015, p. 195-201, Series: Methods in Molecular Biology
Chung, Kenny K K
Book chapter

2012 2

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease

Journal of neurochemistry, v. 122, (2), July 2012, p. 404-414
Xie, Weilin; Chung, Kenny K.K.
Article

The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson's Disease

PLoS ONE, v. 7, (6), June 2012
Wan, Oi Wan; Chung, Kenny K.K.
Article

2011 4

P32 regulates mitochondrial morphology and dynamics through parkin

Neuroscience, v. 199, 2011, p. 346-358
Li, Youjun; Wan, Oi Wan; Xie, W.; Chung, Kenny K.K.
Article

Involvement of S-nitrosylation in neurodegeneration

Post-translational modifications in health and disease / Edited by Cecilio J. Vidal. New York : Springer, 2011, p. 79-95
Chung, Kenny K.K.; Li, Y.
Book chapter

S-Nitrosylation of Cdk5 Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development

Zhang, P.; Yu,P-C; Tsang, A.H.; Chen, Y.; Fu, Kit Yu; Fu, WY; Chung, Kenny Ka Kin; Ip, Nancy Yuk-Yu
Conference paper

The role of alpha-synuclein aggregation in Parkinson's disease

13th International Neuroscience Winter Conference, Sölden Austria, 2011
Wan, Oi Wan; Chung, Kenny
Conference paper

2010 5

Emerging roles of nitric oxide in neurodegeneration

Nitric oxide-biology and CHEMISTRY, v. 22, (4), 2010, MAY 15, p. 290-295
Chung, Kenny K.K.; David, Karen K.
Article

Modulation of pro-survival proteins by S-nitrosylation: implications for neurodegeneration

Apoptosis, v. 15, (11), Nov 2010, p. 1364-1370
Chung, Kenny KK
Article

New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease

BIOCHIMICA ET BIOPHYSICA acta-molecular Basis OF Disease, v. 1802, (11), 2010, NOV, p. 935-941
Xie, Weilin; Wan, Oi Wan; Chung, Kenny K.K.
Article

S-Nitrosylation of Cyclin-Dependent Kinase 5 (Cdk5) Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development

Journal of Neuroscience, v. 30, (43), October 2010, p. 14366-14370
Zhang, Peng; Yu, Peichun; Tsang, Anthony H.K.; Chen, Yu; Fu, Kit Yu; Fu, Wing Yu; Chung, Kenny K.K.; Ip, Nancy Yuk-Yu
Article

Regulation of Cyclin-Dependent Kinase-5 Activity by S-Nitrosylation

Fu, Wing Yu; Zhang, Peng; Tsang, Anthony H.K.; Xie, S.Y.; Fu, Kit Yu; Chung, Kenny K K; Ip, Nancy Yuk-Yu
Conference paper

2009 4

Oxidative stress and nitrosative stress in Parkinson's disease

Biochim Biophys Acta., 1792, 643-650
Tsang, Anthony H.K.; Chung, Kenny K.K.
Article

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

Proceedings of the National Academy of Sciences of the United States of America, v. 106, (12), 2009, MAR 24, p. 4900-4905
Tsang, Anthony H.K.; Lee, Yun-Il; Ko, Han Seok; Savitt, Joseph M.; Pletnikova, Olga; Troncoso, Juan C.; Dawson, Valina L.; Dawson, Ted M.; Chung, Kenny K.K.
Article

The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease

Journal of neurochemistry, v. 110, (1), 2009, JUL, p. 208-219
Lee, F.K.M.; Wong, A.K.Y.; Lee, Y.W.; Wan, Oi Wan; Chan, H.Y.E.; Chung, Kenny K.K.
Article

Characterization of p32 as an interactor of parkin

Society for Neuroscience, Chicago
Li, Yihang; Chung, Kenny K.K.
Conference paper

2008 3

Modification of X-linked Inhibitor of Apoptosis Protein by Nitric Oxide

38th Annual Meeting, Society for Neuroscience, Washington DC, 15-19 Nov 2008
Tsang, Anthony H.K.; Chung, Kenny K.K.
Conference paper

S-nitrosylation of x-linked inhibitor of apoptosis protein (xIAP): Implication to the pathogenesis of Parkinson's disease (PD)

Gordon Research Conference, Molecular and Cellular Neurobiology, 8-13/June/2008
Tsang, Anthony; Chung, Kenny
Conference paper

The role of alpha-synuclein aggregation in the pathogenesis of Parkinson's disease

Gordon Research Conference, Molecular and cellular neurobiology, 8-13/June/2008
Wan, Oi Wan; Chung, Kenny K.K.
Conference paper

2007 1

Gaseous Signaling: Nitric Oxide and Carbon Monoxide as Messenger Molecules

Handbook of Contemporary Neuropharmacology / Editor David Robert Sibley. Hoboken, N.J. : John Wiley & Sons, 2007
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.
Book chapter

2006 2

Say NO to neurodegeneration: Role of S-nitrosylation in neurodegenerative disorders

NeuroSignals, v. 15, (6), 2006, p. 307-313
Chung, Kenny K.K.
Article

Functional study of parkin: insights into the pathogenesis of Parkinson's disease

The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, The Hong Kong Society of Neuroscience, Hong Kong, Symposium VI
Chung, Kenny K.
Conference paper

2005 5

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

Journal of Neuroscience, 25: 7968-7978
Ko, Han S.; Coelln, Rainer V.; Sriram, Sathya R.; Kim, Seong W.; Chung, Kenny K.K.; Pletnikova, Olga; Troncoso, Juan; Johnson, Brett; Saffary, Roya; Goh, Eyleen L.; Song, Hongjun; Park, Bum-Joon; Kim, Min J.; Kim, Sunghoon; Dawson, Valina L.; Dawson, Ted M.
Article

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

Human Molecular Genetics, 14: 2571-2586
Sriram, Sathya R.; Li, Xiaojie; Ko, Han S.; Chung, Kenny K.K.; Wong, Esther; Lim, Kah L.; Dawson, Valina L.; Dawson, Ted M.
Article

Nitric oxide, S-nitrosylation and neurodegeneration.

Cellular and Molecular Biology, 51: 247-254
Chung, Kenny K.K.; Dawson, Ted M.; Dawson, Valina L.
Article

Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation

J. Neurosci., v. 25, 2005, p. 2002-2009
Lim, K.L.; Chew, K.C.M.; Tan, J.M.M.; Wang, C.; Chung, Kenny K.K.; Zhang, Y.; Tanaka, Y.; Wei, W.L.; Engelender, S.; Ross, C.A.; Dawson, V.L.; Dawson, T.M.
Article

S-nitrosylation in Parkinson's disease and related neurodegenerative disorders

Nitric Oxide, Part E / Edited by Lester Packer, and Enrique Cadenas. London : Academic Press, 2005, p. 139-150, Ch. 14. Book Series: Methods in Enzymology. v. 396
Chung, Kenny K.K.; Dawson, Valina L.; Dawson, Ted M.
Book chapter

2004 2

Parkin and HSP70 sacked by BAG5

Neuron 44, 2004, p. 899-901
Chung, Kenny K.K.; Dawson, T.M.
Article

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

Science, v. 304, (5675), 2004, p. 1328-1331
Chung, Kenny K.K.; Thomas, B.; Li, X.; Pletnikova, O.; Troncoso, J.C.; Marsh, L.; Dawson, V.L.; Dawson, T.M.
Article

2003 2

New insights into Parkinson's disease

J Neurol 250 Suppl 3, 2003, p. 15-24
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.
Article

SEPT5_v2 is a parkin-binding protein

Brain Res Mol Brain Res, v. 117, (2), 2003, p. 179-189
Choi, Peter; Snyder, Heather M.; Petrucelli, Leonard; Theisler, Catherine M.; Chong, Matthew; Zhang, Yongjie; Kah Leong, Lim; Chung, Kenny K.K.; Kehoe, Kathryn; D'Adamio, Luciano D.; Lee, John; Cochran, Elizabeth J.; Bowser, Robert P.; Dawson, Ted Murray; Wolozin, Benjamin L.
Article

2001 2

Parkin ubiquitinates the alpha-synuclein interacting protein, synphilin-1: implications for Lewy body formation in Parkinson"s disease

Nature Med., v. 7, (10), 2001, p. 1144-1150
Chung, Kenny K.K.; Zhang, Y.; Lim, K.L.; Tanaka, Y.; Huang, H.; Gao, J.; Ross, C.; Dawson, V.L.; Dawson, T.M.
Article

The role of the ubiquitin proteasomal pathway in Parkinson's Disease and other neurodegenerative disorders

TINS., v. 24, (11), 2001, p. S7-S14
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.
Article

2000 2

C-fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin

Neuroscience, v. 95, (2), 2000, p. 453-463
Chung, Kenny K.K.; Martinez, M.; Herbert,J
Article

Parkin functions as an E3-dependent ubiquitin-protein ligase and promotes the degradation of synaptic vesicle associated protein

CDCrel-1. Proc .Natl. Acad. Sci. USA, v. 97, (24), 2000, p. 13354-13359
Zhang, Y.; Gao, J.; Chung, Kenny K.K.; Huang, H.; Dawson, V.L.; Dawson, T.M.
Article

1999 1

Central serotonin depletion modulates the behavioural tendocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats

Neuroscience, v, 92, (2), 1999, p. 613-625.
Chung, Kenny K.K.; Martinez, M.; Herbert, J.
Article

1997 1

The antigenic sites of trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties

Life Sciences, v. 61, (23), 1997, p. 2291-2303
Mulot, S.; Chung, Kenny K.K.; Li, X.B.; Wong, C.C.; Ng, T.B.; Shaw, P.C.
Article

No Publications

Teaching Assignment

2024-25 Fall 0 2023-24 Summer 1 2023-24 Spring 5 2023-24 Winter 0 2023-24 Fall 5 2022-23 Summer 1

BTEC5210

Principles and Application in Biotechnology

BIBU1010	Biotechnology and Business Seminar
BIBU4840	Biotechnology and Business Capstone Project
BIBU4850	Biotechnology and Business Project Research
LIFS4980	Biological Science Project Research II
LIFS5260	Biochemical and Molecular Basis of Diseases

BIBU4820	Biotechnology Entrepreneurship and Business Operations
BIBU4840	Biotechnology and Business Capstone Project
LIFS4950	Neurochemistry
LIFS4970	Biological Science Project Research I
LIFS6112G	Current Topics in Neuroscience

BTEC5210

Principles and Application in Biotechnology

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

NG, Ka Wai
Life Science

Graduated RPGs

Doctor of Philosophy

SUNG, Chun Chau
Life Science( Completed in 2021 )

Master of Philosophy

LAM, Wai Yun
Life Science( Completed in 2021 )

Projects

From January 2022 to December 2024

All Projects 3 Leading Projects 1 Participating Projects 2

The Role of Relaxin in Alleviating Type 2 Diabetes Mellitus Symptoms and Providing Neuroprotection Against Parkinson’s Disease.

研究鬆弛素如何減緩II類糖尿病癥狀以及探究其為柏金遜疾病患者提供神經保護的可能性 Leading

ALSKY-Z Pharma Limited, Innovation and Technology Fund
Project Team (HKUST)
CHUNG Kenny K (Lead)

TSIM Karl Wah Keung
2022 - 2024
A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases

以幹細胞方法解析神經退行性疾病的分子基礎 Participating

RGC - Theme-based Research Scheme
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

CHEUNG Tom

CHUNG Kenny K

FU Amy Kit Yu

QU Jianan

TSIM Karl Wah Keung

WONG Yung Hou

WU Zhenguo
2019 -
State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)

分子神經科學國家重點實驗室（香港科技大學） Participating

Innovation and Technology Fund
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

CHOW King Lau

CHUNG Kenny K

GUO Zhihong

HUANG Pingbo

LIANG Chun

POON Randy Yat Choi

TSIM Karl Wah Keung

WONG Joseph Tin Yum

WONG Yung Hou

WU Zhenguo

ZHU Guang
2011 -

Research Interest

Publications

2024 1

2020 1

2018 1

2017 2

2015 2

2012 2

2011 4

2010 5

2009 4

2008 3

2007 1

2006 2

2005 5

2004 2

2003 2

2001 2

2000 2

1999 1

1997 1

Article 1

Article 1

Article 1

Article 1

Conference paper 1

Article 1

Book chapter 1

Article 2

Article 1

Book chapter 1

Conference paper 2

Article 4

Conference paper 1

Article 3

Conference paper 1

Conference paper 3

Book chapter 1

Article 1

Conference paper 1

Article 4

Book chapter 1

Article 2

Article 2

Article 2

Article 2

Article 1

Article 1

2018 1

2017 2

2015 2

2012 2

2011 4

2010 5

2009 4

2008 3

2007 1

2006 2

2005 5

2004 2

2003 2

2001 2

2000 2

1999 1

1997 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

Current RPGs

Graduated RPGs

Projects

From January 2022 to December 2024

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