Faculty Profiles - LIU Kai | The Hong Kong University of Science and Technology

Professor
Division of Life Science
Department of Chemical and Biological Engineering

Associate Director of HKUST-Nan Fung Life Sciences Joint Laboratory

Associate Director of Laboratory Animal Facility

Publications

2024 1

Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum

Developmental Cell, v. 59, (11), June 2024, p. 1396-1409.e5
Song, Yutong; Zhao, Zhihao; Xu, Linyu; Huang, Peiyuan; Gao, Jianyang; Li, Jingxuan; Wang, Xuejie; Zhou, Yiren; Wang, Jinhui; Zhao, Wenting; Wang, Likun; Zheng, Chaogu; Gao, Bo; Jiang, Liwen; Liu, Kai; Guo, Yusong; Yao, Xiaoqiang; Duan, Liting
Article

2023 2

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Neuron, v. 111, (2), January 2023, p. 236-255.e7
Wang, Xu; Yang, Chao; Wang, Xuejie; Miao, Jinmin; Chen, Weitao; Zhou, Yiren; Xu, Ying; An, Yongyan; Cheng, Aifang; Ye, Wenkang; Chen, Mengxian; Song, Dong; Yuan, Xue; Wang, Jiguang; Qian, Peiyuan; Wu, Angela Ruohao; Zhang, Zhong-Yin; Liu, Kai
Article

Minimally Invasive Microglial and Neuronal Imaging in Mouse Spinal Cord Dorsal Horn

IEEE Journal of Selected Topics in Quantum Electronics, v. 29, (4), July 2023, article number 9991155
Wu, Wanjie; He, Sicong; Chen, Yujun; Chen, Congping; Fu, Yiming; Liu, Kai; Qu, Jianan
Article

2022 2

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

Nature Communications, v. 13, (1), April 2022, article number 1959
Wu, Wanjie; He, Sicong; Wu, Junqiang; Chen, Conping; Li, Xuesong; Liu, Kai; Qu, Jianan Y.
Article

RSK1 promotes mammalian axon regeneration by inducing the synthesis of regeneration-related proteins

PLoS Biology, v. 20, (6), June 2022, article number e3001653
Mao, Susu; Chen, Yuanyuan; Feng, Wei; Zhou, Songlin; Jiang, Chunyi; Zhang, Junjie; Liu, Xiaohong; Qian, Tianmei; Liu, Kai; Wang, Yaxian; Yao, Chun; Gu, Xiaosong; Yu, Bin
Article

2021 1

A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D

Proceedings of the National Academy of Sciences of the United States of America, v. 118, (45), 9 November 2021, article number e2106143118
Wu, Ming-Yu; Wong, Alex Y. H.; Leung, Jong-Kai; Kam, Chuen; Wu, Kenneth Lap-Kei; Chan, Ying-Shing; Liu, Kai; Ip, Nancy Yuk-yu; Chen, Sijie
Article

2020 5

Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo

Light: Science & Applications, v. 9, (1), May 2020, article number 79
Qin, Zhongya; He, Sicong; Yang, Chao; Yung, Jasmine Sum-Yee; Chen, Congping; Leung, Christopher Kai-Shun; Liu, Kai; Qu, Jianan
Article

Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly

Science Advances, v. 6, (41), 7 October 2020, article number eabc4824
Jiang, Bojing; Liu, Xiaotian; Yang, Chao; Yang, Zhongguang; Luo, Jiren; Kou, Songzi; Liu, Kai; Sun, Fei
Article

Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration

Neuron, v. 105, (2), January 2020, p. 276-292.e5
Yang, Chao; Wang, Xu; Wang, Jianying; Wang, Xuejie; Chen, Weitao; Lu, Na; Symeon, Siniossoglou; Yao, Zhongping; Liu, Kai
Article

Adaptive optics two-photon microscopy for in vivo imaging of mouse retina

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 11248, February 2020, article number 112480L
Qin, Zhongya; He, Sicong; Chen, Congping; Yang, Chao; Yung, Jasmine; Wu, Wanjie; Leung, Christopher K.S; Liu, Kai; Qu, Jianan
Conference paper

In vivo high-resolution multimodal nonlinear optical microscopy of spinal cord in mice

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 11252, February 2020, article number 112520P
Wu, Wanjie; Qin, Zhongya; Wu, Junqiang; Chen, Congping; Chen, Weitao; Liu, Kai; Qu, Jianan
Conference paper

2019 1

Rapid Depletion of ESCRT Protein Vps4 Underlies Injury-induced Autophagic Impediment and Wallerian Degeneration

Science Advances, v. 5, (2), February 2019, article number eaav4971
Wang, Haiqiong; Wang, Xuejie; Zhang, Kai; Wang, Qingyao; Cao, Xu; Wang, Zhao; Zhang, Shuang; Li, Ang; Liu, Kai; Fang, Yanshan
Article

2018 5

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Cell Transplantation, v. 27, (2), February 2018, p. 310-324
Liu, Kai; CANR; IANR
Article

Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

Neuron, v. 97, (2), January 2018, p. 313-325.e6
Weng, Yi-Lan; Wang, Xu; An, Ran; Cassin, Jessica; Vissers, Caroline; Liu, Yuanyuan; Liu, Yajing; Xu, Tianlei; Wang, Xinyuan; Wong, Samuel Zheng Hao; Joseph, Jessica; Dore, Louis C.; Dong, Qiang; Zheng, Wei; Jin, Peng; Wu, Hao; Shen, Bin; Zhuang, Xiaoxi; He, Chuan; Liu, Kai; Song, Hongjun; Ming, Guo-li
Article

p110α of PI3K is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells

EMBO Journal, v. 37, (8), April 2018, article number e98239
Wang, Gang; Zhu, Han; Situ, Chenghao; Han, Lifang; Yu, Youqian; Cheung, Tom H.; Liu, Kai; Wu, Zhenguo
Article

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1

Frontiers in Molecular Neuroscience, v. 10, January 2018, article number 445
Lou, Wilson Pak-Kin; Mateos, Alvaro; Koch, Marta; Klussman, Stefan; Yang, Chao; Lu, Na; Kumar, Sachin; Limpert, Stefanie; Goepferich, Manuel; Zschaetzsch, Marlen; Sliwinski, Christopher; Kenzelmann, Marc; Seedorf, Matthias; Maillo, Carlos; Senis, Elena; Grimm, Dirk; Puttagunta, Radhika; Mendez, Raul; Liu, Kai; Hassan, Bassem A.; Martin-villalba, Ana
Article

Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth

ACS Applied Nano Materials, v. 1, (4), March 2018, p. 1579-1585
Liu, Xiaotian; Yang, Xin; Yang, Zhongguang; Luo, jiren; Tian, xiaozhen; Liu, Kai; Kou, Songzi; Sun, Fei
Article

2017 1

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

eLife, v. 6, June 2017, article number e28021
Hu, Wenbao; Yu, Xiaojie; Liu, Zhengzhao; Sun, Ying; Chen, Xibing; Yang, Xin; Li, Xiaofen; Lam, Wai Kwan; Duan, Yuanyuan; Cao, Xu; Steller, Hermann; Liu, Kai; Huang, Pingbo
Article

2016 5

A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (22), May 2016, p. E3081-E3090
Zeng, Menglong; Shang, Yuan; Guo, Tingfeng; He, Qinghai; Yung, Wing-Ho; Liu, Kai; Zhang, Mingjie
Article

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai
Article

Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion

eNeuro, v. 3, (6), December 2016, article number e0358, p. 1-17
Chen, Weitao; Lu, Na; Ding, Yue; Wang, Yuan; Chan, Leung Ting; Wang, Xu; Gao, Xin; Jiang, Songshan; Liu, Kai
Article

The progress in optic nerve regeneration, where are we?

Neural Regeneration Research, v. 11, (1), January 2016, p. 32-36
Shum, Jennifer Wei Huen; Liu, Kai; So, Kwok Fai
Article

Variable Laterality of Corticospinal Tract Axons that Regenerate After Spinal Cord Injury as a Result of PTEN Deletion or Knock-Down

Journal of Comparative Neurology, v. 524, (13), September 2016, p. 2654-2676
Willenberg, Rafer; Zukor, Katherine; Liu, Kai; He, Zhigang; Steward, Oswald
Article

2015 3

Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice

Journal of Neuroscience, v. 35, (16), April 2015, p. 6413-6428
Geoffroy, Cedric G.; Lorenzana, Ariana O.; Kwan, Jeffrey P.; Lin, Kyle; Ghassemi, Omeed; Ma, Andrew; Xu, Nuo; Creger, Daniel; Liu, Kai; He, Zhigang; Zheng, Binhai
Article

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai
Article

Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury

Journal of Neuroscience, v. 35, (26), July 2015, p. 9754-9763
Du, Kaimeng; Zheng, Susu; Zhang, Qian; Li, Songshan; Gao, Xin; Wang, Juan; Jiang, Liwen; Liu, Kai
Article

2014 1

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

Cell Reports, v. 9, (5), December 2014, p. 1635-1644
Fang, Wei-Qun; Chen, Wei-Wei; Jiang, Liwen; Liu, Kai; Yung, Wing-Ho; Fu, Amy Kit Yu; Ip, Nancy Yuk-Yu
Article

2011 1

Neuronal Intrinsic Mechanisms of Axon Regeneration

Annual Review of Neuroscience, v. 34, July 2011, p. 134-152
Liu, Kai; Tedeschi, Andrea; Park, Kevin Kyungsuk; He, Zhigang
Article

2010 3

Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture

Experimental Neurology, v.229, (1), 2011, May, p.72-79
Babiarz, Joanne; Kane-Goldsmith, Noriko; Basak, Sayantani; Liu, Kai; Young, Wise; Grumet, Martin
Article

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Nature Neuroscience 2010 Sep, v. 13, (9), 2010, p. 1075-1081
Liu, Kai; Lu, Yi; Lee, Jae K.; Samara, Ramsey; Willenberg, Rafer; Sears-Kraxberger, Ilse; Tedeschi, Andrea; Park, Kevin Kyungsuk; Cai, Bin; Xu, Bengang; Connolly, Lauren; Steward, Oswald; Zheng, Binhai; He, Zhigang
Article

PTEN/mTOR and axon regeneration

Experimental Neurology, v. 223, (1), 2010, May, p.45-50
Park, Kevin K.; Liu, Kai; Hu, Yang; Kanter, Jennifer L.; He, Zhigang
Article

2009 1

PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration

Science, v. 326, (5952),October 23 2009, p. 592-596
Shen, Y.; Tenney, AP; Busch, SA; Horn, KP; Cuascut, FX; Liu, Kai; He, Z.; Silver, J.; Flanagan, JG
Article

2008 2

Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury

Molecular and Cellular Neuroscience, v. 39, no. 2, October 2008, p. 258-267
Ji, Benxiu; Case, Lauren C.; Liu, Kai; Shao, Zhaohui; Lee, Xinhua; Yang, Zhongshu; Wang, Joy; Tian, Tim; Shulga-Morskaya, Svetlana; Scott, Martin; He, Zhigang; Relton, Jane K.; Mi, Sha
Article

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

Science, v. 322, no. 5903,November 7 2008, p. 963-966
Park, Kevin Kyungsuk; Liu, Kai; Hu, Yang; Smith, Patrice D.; Wang, Chen; Cai, Bin; Xu, Bengang; Connolly, Lauren; Kramvis, Ioannis; Sahin, Mustafa; He, Zhigang
Article

2007 1

Spinal cord injury-induced immune depression syndrome (SCI-IDS)

European Journal of Neuroscience, v. 25, no. 6, March 2007, p. 1743-1747
Riegger, Tino; Conrad, Sabine; Liu, Kai; Schluesener, Hermann J.; Adibzahdeh, Mahdi; Schwab, Han M.
Article

Article 1

Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum

Developmental Cell, v. 59, (11), June 2024, p. 1396-1409.e5
Song, Yutong; Zhao, Zhihao; Xu, Linyu; Huang, Peiyuan; Gao, Jianyang; Li, Jingxuan; Wang, Xuejie; Zhou, Yiren; Wang, Jinhui; Zhao, Wenting; Wang, Likun; Zheng, Chaogu; Gao, Bo; Jiang, Liwen; Liu, Kai; Guo, Yusong; Yao, Xiaoqiang; Duan, Liting

Article 2

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Neuron, v. 111, (2), January 2023, p. 236-255.e7
Wang, Xu; Yang, Chao; Wang, Xuejie; Miao, Jinmin; Chen, Weitao; Zhou, Yiren; Xu, Ying; An, Yongyan; Cheng, Aifang; Ye, Wenkang; Chen, Mengxian; Song, Dong; Yuan, Xue; Wang, Jiguang; Qian, Peiyuan; Wu, Angela Ruohao; Zhang, Zhong-Yin; Liu, Kai

Minimally Invasive Microglial and Neuronal Imaging in Mouse Spinal Cord Dorsal Horn

IEEE Journal of Selected Topics in Quantum Electronics, v. 29, (4), July 2023, article number 9991155
Wu, Wanjie; He, Sicong; Chen, Yujun; Chen, Congping; Fu, Yiming; Liu, Kai; Qu, Jianan

Article 2

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

Nature Communications, v. 13, (1), April 2022, article number 1959
Wu, Wanjie; He, Sicong; Wu, Junqiang; Chen, Conping; Li, Xuesong; Liu, Kai; Qu, Jianan Y.

RSK1 promotes mammalian axon regeneration by inducing the synthesis of regeneration-related proteins

PLoS Biology, v. 20, (6), June 2022, article number e3001653
Mao, Susu; Chen, Yuanyuan; Feng, Wei; Zhou, Songlin; Jiang, Chunyi; Zhang, Junjie; Liu, Xiaohong; Qian, Tianmei; Liu, Kai; Wang, Yaxian; Yao, Chun; Gu, Xiaosong; Yu, Bin

Article 1

A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D

Proceedings of the National Academy of Sciences of the United States of America, v. 118, (45), 9 November 2021, article number e2106143118
Wu, Ming-Yu; Wong, Alex Y. H.; Leung, Jong-Kai; Kam, Chuen; Wu, Kenneth Lap-Kei; Chan, Ying-Shing; Liu, Kai; Ip, Nancy Yuk-yu; Chen, Sijie

Article 3

Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo

Light: Science & Applications, v. 9, (1), May 2020, article number 79
Qin, Zhongya; He, Sicong; Yang, Chao; Yung, Jasmine Sum-Yee; Chen, Congping; Leung, Christopher Kai-Shun; Liu, Kai; Qu, Jianan

Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly

Science Advances, v. 6, (41), 7 October 2020, article number eabc4824
Jiang, Bojing; Liu, Xiaotian; Yang, Chao; Yang, Zhongguang; Luo, Jiren; Kou, Songzi; Liu, Kai; Sun, Fei

Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration

Neuron, v. 105, (2), January 2020, p. 276-292.e5
Yang, Chao; Wang, Xu; Wang, Jianying; Wang, Xuejie; Chen, Weitao; Lu, Na; Symeon, Siniossoglou; Yao, Zhongping; Liu, Kai

Conference paper 2

Adaptive optics two-photon microscopy for in vivo imaging of mouse retina

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 11248, February 2020, article number 112480L
Qin, Zhongya; He, Sicong; Chen, Congping; Yang, Chao; Yung, Jasmine; Wu, Wanjie; Leung, Christopher K.S; Liu, Kai; Qu, Jianan

In vivo high-resolution multimodal nonlinear optical microscopy of spinal cord in mice

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 11252, February 2020, article number 112520P
Wu, Wanjie; Qin, Zhongya; Wu, Junqiang; Chen, Congping; Chen, Weitao; Liu, Kai; Qu, Jianan

Article 1

Rapid Depletion of ESCRT Protein Vps4 Underlies Injury-induced Autophagic Impediment and Wallerian Degeneration

Science Advances, v. 5, (2), February 2019, article number eaav4971
Wang, Haiqiong; Wang, Xuejie; Zhang, Kai; Wang, Qingyao; Cao, Xu; Wang, Zhao; Zhang, Shuang; Li, Ang; Liu, Kai; Fang, Yanshan

Article 5

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Cell Transplantation, v. 27, (2), February 2018, p. 310-324
Liu, Kai; CANR; IANR

Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

Neuron, v. 97, (2), January 2018, p. 313-325.e6
Weng, Yi-Lan; Wang, Xu; An, Ran; Cassin, Jessica; Vissers, Caroline; Liu, Yuanyuan; Liu, Yajing; Xu, Tianlei; Wang, Xinyuan; Wong, Samuel Zheng Hao; Joseph, Jessica; Dore, Louis C.; Dong, Qiang; Zheng, Wei; Jin, Peng; Wu, Hao; Shen, Bin; Zhuang, Xiaoxi; He, Chuan; Liu, Kai; Song, Hongjun; Ming, Guo-li

p110α of PI3K is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells

EMBO Journal, v. 37, (8), April 2018, article number e98239
Wang, Gang; Zhu, Han; Situ, Chenghao; Han, Lifang; Yu, Youqian; Cheung, Tom H.; Liu, Kai; Wu, Zhenguo

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1

Frontiers in Molecular Neuroscience, v. 10, January 2018, article number 445
Lou, Wilson Pak-Kin; Mateos, Alvaro; Koch, Marta; Klussman, Stefan; Yang, Chao; Lu, Na; Kumar, Sachin; Limpert, Stefanie; Goepferich, Manuel; Zschaetzsch, Marlen; Sliwinski, Christopher; Kenzelmann, Marc; Seedorf, Matthias; Maillo, Carlos; Senis, Elena; Grimm, Dirk; Puttagunta, Radhika; Mendez, Raul; Liu, Kai; Hassan, Bassem A.; Martin-villalba, Ana

Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth

ACS Applied Nano Materials, v. 1, (4), March 2018, p. 1579-1585
Liu, Xiaotian; Yang, Xin; Yang, Zhongguang; Luo, jiren; Tian, xiaozhen; Liu, Kai; Kou, Songzi; Sun, Fei

Article 1

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

eLife, v. 6, June 2017, article number e28021
Hu, Wenbao; Yu, Xiaojie; Liu, Zhengzhao; Sun, Ying; Chen, Xibing; Yang, Xin; Li, Xiaofen; Lam, Wai Kwan; Duan, Yuanyuan; Cao, Xu; Steller, Hermann; Liu, Kai; Huang, Pingbo

Article 5

A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (22), May 2016, p. E3081-E3090
Zeng, Menglong; Shang, Yuan; Guo, Tingfeng; He, Qinghai; Yung, Wing-Ho; Liu, Kai; Zhang, Mingjie

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai

Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion

eNeuro, v. 3, (6), December 2016, article number e0358, p. 1-17
Chen, Weitao; Lu, Na; Ding, Yue; Wang, Yuan; Chan, Leung Ting; Wang, Xu; Gao, Xin; Jiang, Songshan; Liu, Kai

The progress in optic nerve regeneration, where are we?

Neural Regeneration Research, v. 11, (1), January 2016, p. 32-36
Shum, Jennifer Wei Huen; Liu, Kai; So, Kwok Fai

Variable Laterality of Corticospinal Tract Axons that Regenerate After Spinal Cord Injury as a Result of PTEN Deletion or Knock-Down

Journal of Comparative Neurology, v. 524, (13), September 2016, p. 2654-2676
Willenberg, Rafer; Zukor, Katherine; Liu, Kai; He, Zhigang; Steward, Oswald

Article 3

Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice

Journal of Neuroscience, v. 35, (16), April 2015, p. 6413-6428
Geoffroy, Cedric G.; Lorenzana, Ariana O.; Kwan, Jeffrey P.; Lin, Kyle; Ghassemi, Omeed; Ma, Andrew; Xu, Nuo; Creger, Daniel; Liu, Kai; He, Zhigang; Zheng, Binhai

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai

Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury

Journal of Neuroscience, v. 35, (26), July 2015, p. 9754-9763
Du, Kaimeng; Zheng, Susu; Zhang, Qian; Li, Songshan; Gao, Xin; Wang, Juan; Jiang, Liwen; Liu, Kai

Article 1

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

Cell Reports, v. 9, (5), December 2014, p. 1635-1644
Fang, Wei-Qun; Chen, Wei-Wei; Jiang, Liwen; Liu, Kai; Yung, Wing-Ho; Fu, Amy Kit Yu; Ip, Nancy Yuk-Yu

Article 1

Neuronal Intrinsic Mechanisms of Axon Regeneration

Annual Review of Neuroscience, v. 34, July 2011, p. 134-152
Liu, Kai; Tedeschi, Andrea; Park, Kevin Kyungsuk; He, Zhigang

Article 3

Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture

Experimental Neurology, v.229, (1), 2011, May, p.72-79
Babiarz, Joanne; Kane-Goldsmith, Noriko; Basak, Sayantani; Liu, Kai; Young, Wise; Grumet, Martin

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Nature Neuroscience 2010 Sep, v. 13, (9), 2010, p. 1075-1081
Liu, Kai; Lu, Yi; Lee, Jae K.; Samara, Ramsey; Willenberg, Rafer; Sears-Kraxberger, Ilse; Tedeschi, Andrea; Park, Kevin Kyungsuk; Cai, Bin; Xu, Bengang; Connolly, Lauren; Steward, Oswald; Zheng, Binhai; He, Zhigang

PTEN/mTOR and axon regeneration

Experimental Neurology, v. 223, (1), 2010, May, p.45-50
Park, Kevin K.; Liu, Kai; Hu, Yang; Kanter, Jennifer L.; He, Zhigang

Article 1

PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration

Science, v. 326, (5952),October 23 2009, p. 592-596
Shen, Y.; Tenney, AP; Busch, SA; Horn, KP; Cuascut, FX; Liu, Kai; He, Z.; Silver, J.; Flanagan, JG

Article 2

Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury

Molecular and Cellular Neuroscience, v. 39, no. 2, October 2008, p. 258-267
Ji, Benxiu; Case, Lauren C.; Liu, Kai; Shao, Zhaohui; Lee, Xinhua; Yang, Zhongshu; Wang, Joy; Tian, Tim; Shulga-Morskaya, Svetlana; Scott, Martin; He, Zhigang; Relton, Jane K.; Mi, Sha

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

Science, v. 322, no. 5903,November 7 2008, p. 963-966
Park, Kevin Kyungsuk; Liu, Kai; Hu, Yang; Smith, Patrice D.; Wang, Chen; Cai, Bin; Xu, Bengang; Connolly, Lauren; Kramvis, Ioannis; Sahin, Mustafa; He, Zhigang

Article 1

Spinal cord injury-induced immune depression syndrome (SCI-IDS)

European Journal of Neuroscience, v. 25, no. 6, March 2007, p. 1743-1747
Riegger, Tino; Conrad, Sabine; Liu, Kai; Schluesener, Hermann J.; Adibzahdeh, Mahdi; Schwab, Han M.

2018 5

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Cell Transplantation, v. 27, (2), February 2018, p. 310-324
Liu, Kai; CANR; IANR
Article

Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

Neuron, v. 97, (2), January 2018, p. 313-325.e6
Weng, Yi-Lan; Wang, Xu; An, Ran; Cassin, Jessica; Vissers, Caroline; Liu, Yuanyuan; Liu, Yajing; Xu, Tianlei; Wang, Xinyuan; Wong, Samuel Zheng Hao; Joseph, Jessica; Dore, Louis C.; Dong, Qiang; Zheng, Wei; Jin, Peng; Wu, Hao; Shen, Bin; Zhuang, Xiaoxi; He, Chuan; Liu, Kai; Song, Hongjun; Ming, Guo-li
Article

p110α of PI3K is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells

EMBO Journal, v. 37, (8), April 2018, article number e98239
Wang, Gang; Zhu, Han; Situ, Chenghao; Han, Lifang; Yu, Youqian; Cheung, Tom H.; Liu, Kai; Wu, Zhenguo
Article

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1

Frontiers in Molecular Neuroscience, v. 10, January 2018, article number 445
Lou, Wilson Pak-Kin; Mateos, Alvaro; Koch, Marta; Klussman, Stefan; Yang, Chao; Lu, Na; Kumar, Sachin; Limpert, Stefanie; Goepferich, Manuel; Zschaetzsch, Marlen; Sliwinski, Christopher; Kenzelmann, Marc; Seedorf, Matthias; Maillo, Carlos; Senis, Elena; Grimm, Dirk; Puttagunta, Radhika; Mendez, Raul; Liu, Kai; Hassan, Bassem A.; Martin-villalba, Ana
Article

Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth

ACS Applied Nano Materials, v. 1, (4), March 2018, p. 1579-1585
Liu, Xiaotian; Yang, Xin; Yang, Zhongguang; Luo, jiren; Tian, xiaozhen; Liu, Kai; Kou, Songzi; Sun, Fei
Article

2017 1

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

eLife, v. 6, June 2017, article number e28021
Hu, Wenbao; Yu, Xiaojie; Liu, Zhengzhao; Sun, Ying; Chen, Xibing; Yang, Xin; Li, Xiaofen; Lam, Wai Kwan; Duan, Yuanyuan; Cao, Xu; Steller, Hermann; Liu, Kai; Huang, Pingbo
Article

2016 5

A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (22), May 2016, p. E3081-E3090
Zeng, Menglong; Shang, Yuan; Guo, Tingfeng; He, Qinghai; Yung, Wing-Ho; Liu, Kai; Zhang, Mingjie
Article

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (7), February 2016, p. 1937-1942
Li, Songshan; Yang, Chao; Zhang, Li; Gao, Xin; Wang, Xuejie; Liu, Wen; Wang, Yuqi; Jiang, Songshan; Wong, Yung Hou; Zhang, Yifeng; Liu, Kai
Article

Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion

eNeuro, v. 3, (6), December 2016, article number e0358, p. 1-17
Chen, Weitao; Lu, Na; Ding, Yue; Wang, Yuan; Chan, Leung Ting; Wang, Xu; Gao, Xin; Jiang, Songshan; Liu, Kai
Article

The progress in optic nerve regeneration, where are we?

Neural Regeneration Research, v. 11, (1), January 2016, p. 32-36
Shum, Jennifer Wei Huen; Liu, Kai; So, Kwok Fai
Article

Variable Laterality of Corticospinal Tract Axons that Regenerate After Spinal Cord Injury as a Result of PTEN Deletion or Knock-Down

Journal of Comparative Neurology, v. 524, (13), September 2016, p. 2654-2676
Willenberg, Rafer; Zukor, Katherine; Liu, Kai; He, Zhigang; Steward, Oswald
Article

2015 3

Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice

Journal of Neuroscience, v. 35, (16), April 2015, p. 6413-6428
Geoffroy, Cedric G.; Lorenzana, Ariana O.; Kwan, Jeffrey P.; Lin, Kyle; Ghassemi, Omeed; Ma, Andrew; Xu, Nuo; Creger, Daniel; Liu, Kai; He, Zhigang; Zheng, Binhai
Article

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Neurobiology of Disease, v. 73, January 2015, p. 366-376
Li, Songshan; He, Qinghai; Wang, Hao; Tang, Xuming; Ho, Kam Wing; Gao, Xin; Zhang, Qian; Shen, Yang; Cheung, Annie; Wong, Francis; Wong, Yung Hou; Ip, Nancy Yuk-yu; Jiang, Liwen; Yung, Wing Ho; Liu, Kai
Article

Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury

Journal of Neuroscience, v. 35, (26), July 2015, p. 9754-9763
Du, Kaimeng; Zheng, Susu; Zhang, Qian; Li, Songshan; Gao, Xin; Wang, Juan; Jiang, Liwen; Liu, Kai
Article

2014 1

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

Cell Reports, v. 9, (5), December 2014, p. 1635-1644
Fang, Wei-Qun; Chen, Wei-Wei; Jiang, Liwen; Liu, Kai; Yung, Wing-Ho; Fu, Amy Kit Yu; Ip, Nancy Yuk-Yu
Article

2011 1

Neuronal Intrinsic Mechanisms of Axon Regeneration

Annual Review of Neuroscience, v. 34, July 2011, p. 134-152
Liu, Kai; Tedeschi, Andrea; Park, Kevin Kyungsuk; He, Zhigang
Article

2010 3

Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture

Experimental Neurology, v.229, (1), 2011, May, p.72-79
Babiarz, Joanne; Kane-Goldsmith, Noriko; Basak, Sayantani; Liu, Kai; Young, Wise; Grumet, Martin
Article

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Nature Neuroscience 2010 Sep, v. 13, (9), 2010, p. 1075-1081
Liu, Kai; Lu, Yi; Lee, Jae K.; Samara, Ramsey; Willenberg, Rafer; Sears-Kraxberger, Ilse; Tedeschi, Andrea; Park, Kevin Kyungsuk; Cai, Bin; Xu, Bengang; Connolly, Lauren; Steward, Oswald; Zheng, Binhai; He, Zhigang
Article

PTEN/mTOR and axon regeneration

Experimental Neurology, v. 223, (1), 2010, May, p.45-50
Park, Kevin K.; Liu, Kai; Hu, Yang; Kanter, Jennifer L.; He, Zhigang
Article

2009 1

PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration

Science, v. 326, (5952),October 23 2009, p. 592-596
Shen, Y.; Tenney, AP; Busch, SA; Horn, KP; Cuascut, FX; Liu, Kai; He, Z.; Silver, J.; Flanagan, JG
Article

2008 2

Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury

Molecular and Cellular Neuroscience, v. 39, no. 2, October 2008, p. 258-267
Ji, Benxiu; Case, Lauren C.; Liu, Kai; Shao, Zhaohui; Lee, Xinhua; Yang, Zhongshu; Wang, Joy; Tian, Tim; Shulga-Morskaya, Svetlana; Scott, Martin; He, Zhigang; Relton, Jane K.; Mi, Sha
Article

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

Science, v. 322, no. 5903,November 7 2008, p. 963-966
Park, Kevin Kyungsuk; Liu, Kai; Hu, Yang; Smith, Patrice D.; Wang, Chen; Cai, Bin; Xu, Bengang; Connolly, Lauren; Kramvis, Ioannis; Sahin, Mustafa; He, Zhigang
Article

2007 1

Spinal cord injury-induced immune depression syndrome (SCI-IDS)

European Journal of Neuroscience, v. 25, no. 6, March 2007, p. 1743-1747
Riegger, Tino; Conrad, Sabine; Liu, Kai; Schluesener, Hermann J.; Adibzahdeh, Mahdi; Schwab, Han M.
Article

Teaching Assignment

LIFS6112H	Current Topics in Neuroscience
LIFS6170	Special Topics in Molecular, Cell and Developmental Biology
SCIE1130	Scientific Understanding of Our World
SCIE4500	IRE Research Project II
UROP1100N	Undergraduate Research Opportunities Series 1
UROP2100N	Undergraduate Research Opportunities Series 2

UROP1100M

Undergraduate Research Opportunities Series 1

LIFS3150	Biostatistics
LIFS4910A	Independent Study
LIFS4981	Biochemistry and Cell Biology Project Research II
LIFS5260	Biochemical and Molecular Basis of Diseases
SCIE3500	IRE Research Project I
UROP1100L	Undergraduate Research Opportunities Series 1

LIFS4910A	Independent Study
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4971	Biochemistry and Cell Biology Project Research I
LIFS6112G	Current Topics in Neuroscience
LIFS6170	Special Topics in Molecular, Cell and Developmental Biology
UROP4100K	Undergraduate Research Opportunities Series 4

UROP1000	Undergraduate Research Opportunities
UROP3100J	Undergraduate Research Opportunities Series 3

No Teaching Assignments

Research Interest

Publications

2024 1

2023 2

2022 2

2021 1

2020 5

2019 1

2018 5

2017 1

2016 5

2015 3

2014 1

2011 1

2010 3

2009 1

2008 2

2007 1

Article 1

Article 2

Article 2

Article 1

Article 3

Conference paper 2

Article 1

Article 5

Article 1

Article 5

Article 3

Article 1

Article 1

Article 3

Article 1

Article 2

Article 1

2018 5

2017 1

2016 5

2015 3

2014 1

2011 1

2010 3

2009 1

2008 2

2007 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

Current RPGs

Graduated RPGs

Projects

From January 2022 to December 2024

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