Faculty Profiles - LEUNG Ka Wing | The Hong Kong University of Science and Technology

Ka Wing LEUNG
梁嘉榮

PhD in Biology
The Hong Kong University of Science and Technology, 2009

Lecturer II
Division of Life Science

(852) 2358 5892
lkwing@ust.hk
Room 5459

ORCID

0000-0002-6137-3877

ResearcherID

DSI-4732-2022

Scopus ID

8843438300

Research Interest Publications Projects Teaching Assignment

Research Interest

Drug development
Molecular and cellular neuroscience
Traditional Chinese herbal medicine
Bioanalytical chemistry
Mass spectrometry-based interactomics

Publications

All Years 61 2026 3 2025 8 2024 2 2023 2 2022 4 2021 2 2020 40

2026 3

A chemically synthesized resveratrol dimer is a potent inhibitor of vascular endothelial growth factor (VEGF).

Archives of Clinical and Biomedical Research, v. 10, (2), p. 108-116
LIN, Shengying; GUO, Suisui; TANG, Wai Lun; YE, Yutong; HO, Yuen Man; DUAN, Ran; LEUNG, Ka Wing; ZHOU, Jianlong; DONG, Tingxia; TSIM, Karl Wah Keung
Article

From biodiversity to clinical translation: a global review of lichen-derived natural products and their pharmacological potential

Pharmacological Research - Natural Products, v. 10, article number 100456
Yang, Meixia; Lyu, Lisha; Wang, Xinyu; Lin, Shengying; Leung, Ka Wing; Dong, Tina Tingxia; Wang, Lisong; Tsim, Karl Wah Keung
Article

Natural source, chemical classification and medicinal application of the stilbene-type compounds: a review of structural nodification around stilbene scaffold

Molecules, v. 31, (13), article number 2208
Lin, Shengying; Tang, Roy Wai Lun; Duan, Ran; Leung, Ka Wing; Dong, Tina Ting Xia; Tsim, Karl Wah Keung
Article

2025 8

Design, Synthesis, and Biological Evaluations of a Novel Resveratrol-Type Analogue Against VEGF

Molecules, v. 30, (11), article number 2345
LIN, Shengying; GUO, Suisui; TANG, Wai Lun; YE, Yutong; WU, Jiahui; Ho, Yuen Man; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; Tsim, Karl Wah Keung
Article

Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models

Molecules, v. 30, (2), article number 257
LIN, Shengying; TANG, Wai Lun; YE, Yutong; XIA, Chenxi; WU, Jiahui; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; Tsim, Karl Wah Keung
Article

Drug screening of flavonoids as potential VEGF inhibitors through computational docking and cell models

Paper presented at 2025年中醫藥學術研討會：傳統中醫藥的新藥開發與現代化 (2025 Symposium of Traditional Chinese Medicine: New Drug Development and Modernization of Traditional Chinese Medicine), , Hong Kong, p. 59
LIN, Shengying; TANG, Wai Lun; YE, Yutong; XIA, Chenxi; WU, Jiahui; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; TSIM, Karl Wah Keung; CHEN, Yicun
Conference paper

PT109 promotes neurogenesis in PC12 cells via p38 pathway activation: therapeutic potential for neurological diseases

Zhu, Jiayu; Gao, Xiong; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Pi, Rongbiao; Tsim, Karl Wah Keung
Conference paper

Recycling of Chinese medicine resources - development of pan-health products

Tsim, Karl Wah Keung; Dong, Tingxia; Leung, Ka Wing; Duan, Ran; Lin, Shengying; Gao, Xiong; Xia, Chenxi; Lai, Wing Sze
Conference paper

Sophoricoside, a phytochemical from Fructus Sophorae, promotes hair growth via activation of M4 muscarinic AChR in dermal papilla cells

Yuen, Ka Wing Gary; Lin, Shengying; Tang, Wai Lun; Ye, Yutong; Xia, Chenxi; Wu, Jiahui; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Tsim, Karl Wah Keung
Conference paper

Stictic acid and nonstictic acid as novel therapeutic agents for inhibiting α-synuclein aggregation in Parkinson’s disease

Gao, Jin; Yang, Meixia; Lin, Shengying; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Tsim, Karl Wah Keung
Conference paper

Yu Ping Feng San Prevents the Cisplatin- and 5-FU-Induced Multiple-Drug Resistance of Escherichia coli

Ye, Yutong; Wu, Jiahui; Guo, Suisui; Lai, Wing Sze; Leung, Ka Wing; Gao, Jin; Dong, Tingxia; Tsim, Karl Wah Keung
Conference paper

2024 2

Computational Docking as a Tool in Guiding the Drug Design of Rutaecarpine Derivatives as Potential SARS-CoV-2 Inhibitors

Molecules, v. 29, (11), article number 2636
LIN, Shengying; WANG, Xiaoyang; TANG, Wai Lun; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; HO, Sarah Elizabeth; Miller, Andrew L.; Tsim, Karl Wah Keung
Article

The Extracts of Evodiae Fructus and Stephaniae Tetrandrae Radix Show Synergy in Blocking the Entry of SARS-CoV-2

Journal of Alternative Complementary & Integrative Medicine, v. 10, article number 478
Lin, Shengying; Wang, Xiaoyang; Tang, Wai Lun; Leung, Ka Wing; Duan, Ran; Kwong, Trina; Dong, Tingxia; Ho, Sarah Elizabeth; Miller, Andrew Leitch; Tsim, Karl Wah Keung
Article

2023 2

The Ethanol Extract of Evodiae Fructus and Its Ingredient, Rutaecarpine, Inhibit Infection of SARS-CoV-2 and Inflammatory Responses

International journal of molecular sciences, v. 24, (1), article number 762
LIN, Shengying; WANG, Xiaoyang; GUO, Hongsheng; DAI, Niyu; TANG, Wai Lun; LEE, Hung Chun; LEUNG, Ka Wing; DONG, Tingxia; HO, Sarah Elizabeth; Miller, Andrew L.; Tsim, Karl Wah Keung
Article

The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions

Journal of Functional Foods, v. 107, article number 105607
YANG, Meixia; Cheng, Edwin Hok Chi; OSPONDPANT, Dusadee; TUNG, Ka Ki; Wang, Li Song; LIN, Shengying; LAI, Wing Sze; Wu, Qi Yun; XIA, Yingjie; LEUNG, Ka Wing; DUAN, Ran; DONG, Tingxia; Tsim, Karl Wah Keung
Article

2022 4

Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry

Journal of Virology, v. 96, (24)
CHOI, Sheyne Sta. Ana; CHAN, Ho Hin; CHAN, Ching Man; WANG, Xiaoyang; HO, Sarah Elizabeth; LEUNG, Ka Wing; Tsim, Karl W.K.; Miller, Andrew L.
Article

Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae

Phytomedicine, v. 102, article number 154154
WANG, Xiaoyang; LIN, Shengying; TANG, Wai Lun; LEE, Hung Chun; CHAN, Ho Hin; CHOI, Sheyne Sta. Ana; LEUNG, Ka Wing; HO, Sarah Elizabeth; Miller, Andrew L.; Tsim, Karl Wah Keung
Article

Resveratrol, an Inhibitor Binding to VEGF, Restores the Pathology of Abnormal Angiogenesis in Retinopathy of Prematurity (ROP) in Mice: Application by Intravitreal and Topical Instillation

International journal of molecular sciences, v. 23, (12), article number 6455
Hu, Wei Hui; Zhang, Xiao Yong; LEUNG, Ka Wing; DUAN, Ran; DONG, Tingxia; Qin, Qi Wei; Tsim, Karl Wah Keung
Article

The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease

Molecules, v. 27, (12), article number 3806
LIN, Shengying; WANG, Xiaoyang; TANG, Wai Lun; LEE, Hung Chun; CHAN, Ho Hin; CHOI, Sheyne Sta. Ana; DONG, Tingxia; LEUNG, Ka Wing; HO, Sarah Elizabeth; Miller, Andrew L.; Tsim, Karl Wah Keung
Article

2021 2

Identification of Lingnan Chinese Medicines against COVID-19 Infection

Paper presented at Health Research Symposium 2021
Webb, Sarah E; Chan, Ho Hin; Choi, Sheyne Sta. Ana; Lee, Hung Chun; Leung, Ka Wing; Lin, Shengying; Miller, Andrew Leitch; Tang, Wai Lun; Tsim, Karl Wah Keung; Wang, Xiaoyang
Conference paper

Traditional Chinese medicine promotes the anti-inflammatory effect of probiotics in fighting against skin eczema

Paper presented at International Conference of the Modernization of Chinese Medicine & Health Products (ICMCM 2021)
Chen, Yanxian; Dong, Tingxia; Leung, Ka Wing; Tsim, Karl Wah Keung; Zheng, Zhongyu
Conference paper

2020 2

The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats

Phytomedicine, v. 74, article number 152815
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; DONG, Tingxia; Chen, Yicun; Qin, Qi Wei; Tsim, Karl Wah Keung
Article

The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix

Molecules, v. 25, (24), article number 5914
Kong, Xiang Peng; Ren, Hai Qin; Liu, Etta Y.L.; LEUNG, Ka Wing; Guo, Shu Chen; DUAN, Ran; DONG, Tingxia; Tsim, Karl W.K.
Article

2019 4

Danggui buxue tang, a Chinese herbal decoction containing Astragali radix and Angelicae sinensis Radix, modulates mitochondrial bioenergetics in cultured cardiomyoblasts

Frontiers in Pharmacology, v. 10, (JUN), article number 614
KWAN, Kin Leung; HUANG, Yun; LEUNG, Ka Wing; DONG, Tingxia; Tsim, Karl W.K.
Article

Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents

Journal of Ginseng Research, v. 43, (4), p. 517-526
HUANG, Yun; KWAN, Kin Leung; LEUNG, Ka Wing; YAO, Ping; Wang, Huaiyou; DONG, Tingxia; Tsim, Karl Wah Keung
Article

Mass spectrometry based omics technology to reveal the effect of herbal decoction in cultured osteoblasts

Paper presented at Unknown Event
KWAN, Kin Leung; WONG, Tin Yan; YU, Xiaodan; LEUNG, Ka Wing; DONG, Tingxia; LAM, Hei Ning; TSIM, Karl Wah Keung
Conference paper

Mass-Spectrometry-Based Omics Technology to Reveal the Effect of Herbal Decoction in Cultured Osteoblasts

Paper presented at Unknown Event
KWAN, Kin Leung; WONG, Tin Yan; YU, Xiaodan; LEUNG, Ka Wing; DONG, Tingxia; LAM, Hei Ning; TSIM, Karl Wah Keung
Conference paper

2018 5

Surveillance of drug abuse in Hong Kong by hair analysis using LC-MS/MS

Drug Testing and Analysis, v. 10, (6), p. 977-983
LEUNG, Ka Wing; WONG, Chun Fai; Ho, Janet Y.M.; Yip, Ada W.S.; CHEUNG, Ka Hei; HO, Ka Lam Karen; DUAN, Ran; Tsim, Karl W.K.
Article

The extracts and major compounds derived from astragali radix alter mitochondrial bioenergetics in cultured cardiomyocytes: Comparison of various polar solvents and compounds

International journal of molecular sciences, v. 19, (6), article number 1574
HUANG, Yun; KWAN, Kin Leung; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; DONG, Tingxia; Tsim, Karl Wah Keung
Article

The yin-yang property of Chinese medicinal herbs relates to chemical composition but not anti-oxidative activity: An illustration using spleen-meridian herbs

Frontiers in Pharmacology, v. 9, (NOV), article number 1304
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; Wang, Long; DONG, Tingxia; Chen, Yicun; Tsim, Karl Wah Keung
Article

Comparison of the thermoregulatory effects of spleen-meridian herbs with different herbal properties on yeast induced animal model

Paper presented at Unknown Event
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; WANG, Huai-you; KONG, Xiang-Peng; DONG, Tingxia; CHEN, Yi-Cun; TSIM, Karl Wah Keung
Conference paper

Study on the correlation between “Yin-Yang” nature of spleen-meridian herbs with the chemical composition, antioxidant activity and effects to energy metabolism

Paper presented at International Conference of the Modernization of Chinese Medicine & Health Products (ICMCM) 2018: Inheritance and Innovation - In Commemoration of the 500th Anniversary of the Birth of Li Shizhen, Hong Kong
Wang, Huaiyou; Kong, Xiang-Peng; Dong, Tingxia; Huang, Yun; Leung, Ka Wing; Tsim, Karl Wah Keung; Yao, Ping
Conference paper

2016 2

Determination of hair ketamine cut-off value from Hong Kong ketamine users by LC-MS/MS analysis

Forensic Science International, v. 259, p. 53-58
LEUNG, Ka Wing; WONG, Chun Fai; Ho, Janet Y.M.; Yip, Ada W.S.; Ng, Jenny S.C.; Ip, Stanley P.H.; Ng, Winki Y.Y.; HO, Ka Lam Karen; DUAN, Ran; Zhu, Kevin Y.; Tsim, Karl W.K.
Article

Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species

Pharmaceutica Analytica Acta, v. v. 7, (4), article number 1000474
BI, Dan; ZHANG, L.M.L.; TANG, Wai Lun; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; WONG, Yung Hou; LIN, Huangquan; TSIM, Karl Wah Keung
Article

2014 2

UPLC-MS/MS法測定吸毒者頭發中10種毒品代謝物的含量

药物分析杂志=Chinese Journal of Pharmaceutical Analysis, v. v. 34, p. 516-522
謝, 普; 王, 鐵杰; 殷, 果; 閆, 研; 丁, 振浩; 肖, 麗和; 詹, 華強; 梁, 嘉榮; 李, 璐; 孫, 新珺; 畢, 開順
Article

头发验毒技术和服务平台的研究及应用: 深港创新合作共建头发验毒服务平台( II)

中国药物滥用防治杂志, (20), p. 1-4
谢, 普; 王, 铁杰; 殷, 果; 闫, 研; 丁, 振浩; 肖, 丽和; 詹, 华强; 梁, 嘉荣; 李, 璐; 李, 晓东; 孙, 新珺; 毕, 开顺
Article

2012 3

Isorhamnetin, a flavonol aglycone from Ginkgo biloba L., induces neuronal differentiation of cultured PC12 cells: Potentiating the effect of nerve growth factor

Evidence-based Complementary and Alternative Medicine, v. 2012, article number 278273
XU, Li; CHOI, Cheuk Yiu; Zhu, Kevin Y.; LEUNG, Ka Wing; Guo, Ava J.Y.; Bi, Dan; Xu, Hong; Lau, David T.W.; DONG, Tingxia; Tsim, Karl W.K.
Article

Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair

Analytical and Bioanalytical Chemistry, v. 402, (9), p. 2805-2815
Zhu, Kevin Y.; LEUNG, Ka Wing; Ting, Annie K.L.; WONG, Chun Fai; Ng, Winki Y.Y.; CHOI, Cheuk Yiu; DONG, Tingxia; Wang, Tiejie; Lau, David T.W.; Tsim, Karl W.K.
Article

UPLC-MS /MS 同时测定头发中十种残留毒品含量: 深港创新合作共建头发验毒服务平台

中国药物滥用防治杂志, v. v. 18, (6), p. 317-319
王, 铁杰; 詹, 华强; 孙, 新珺; 肖, 丽和; 殷, 果; 闫, 研; 谢, 普; 丁, 振浩; 梁, 嘉荣; 李, 晓东
Article

2011 3

Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation

Frontiers in Molecular Neuroscience
Chan, Gallant K.L.; Choi, Chi Yan; Leung, K. Wing; Luk, Wilson K.W.; Tsim, Karl Wah Keung; Xu, Sherry L.
Article

The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS

Forensic Science International, v. 208, (1-3), p. 53-58
Zhu, Kevin Y.; LEUNG, Ka Wing; Ting, Annie K.L.; WONG, Chun Fai; Fu, Qiang; Ng, Winki Y.Y.; CHOI, Cheuk Yiu; DONG, Tingxia; Wang, Tiejie; Lau, David T.W.; Tsim, Karl W.K.
Article

The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, v. 879, (11-12), p. 737-742
Zhu, Kevin Y.; Fu, Qiang; LEUNG, Ka Wing; WONG, Chun Fai; CHOI, Cheuk Yiu; Tsim, Karl W.K.
Article

2010 3

A new species of cholinesterase in chicken brain: PRiMA-linked AChE-BChE hybrid tetramer

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chan, GKL; Chen, VP; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung; Zhang, VQ
Conference paper

A novel G-protein-coupled receptor complex: heterodimerization of purinergic P2Y1 and P2Y2 receptors

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chan, GKL; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

Post-translational modification of PRiMA-linked G4 AChE by glycosylation

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chen, VP; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung; Zhang, VQ
Conference paper

2009 3

Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions - Contribution and expression from motor neurons

FEBS Journal, v. 276, (11), p. 3031-3042
LEUNG, Ka Wing; Xie, Heidi Q.; Chen, Vicky P.; MOK, Weng Kei; Chu, Glanice K.Y.; CHOI, Cheuk Yiu; Tsim, Karl W.K.
Article

Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: An inductive effect of neuron differentiation

Brain Research, v. 1265, p. 13-23
Xie, Heidi Q.; CHOI, Cheuk Yiu; LEUNG, Ka Wing; Chen, Vicky P.; Chu, Glanice K.Y.; Tsim, Karl W.K.
Article

The molecular assembly of acetylcholinesterase and butyrylcholinesterase: the formation of PRiMA-linked G4 hybrid

Paper presented at The 6th Asian Biophysics Association (ABA) Symposium organized by the Biophysical Society of Hong Kong and the Hong Kong Society of Neurosciences, Hong Kong
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

2008 5

Myocyte enhancer factor 2 mediates acetylcholine-induced expression of acetylcholinesterase-associated collagen ColQ in cultured myotubes

Molecular and Cellular Neuroscience, v. 39, (3), p. 429-438
Lau, Faye T.C.; CHOI, Cheuk Yiu; Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Zhu, Judy T.T.; BI, Wenchuan; Chu, Glanice K.Y.; Tsim, Karl W.K.
Article

The promoter activity of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in muscle: Suppressive roles of myogenesis and innervating nerve

Chemico-Biological Interactions, v. 175, (1-3), p. 79-82
Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Lau, Faye T.C.; Liu, Lois S.; CHOI, Cheuk Yiu; Tsim, Karl W.K.
Article

Transcriptional control of different subunits of AChE in muscles: Signals triggered by the motor nerve-derived factors

Chemico-Biological Interactions, v. 175, (1-3), p. 58-63
Tsim, Karl W.K.; CHOI, Cheuk Yiu; Xie, Heidi Q.; Zhu, Judy T.T.; LEUNG, Ka Wing; Lau, Faye T.C.; Chu, Glanice K.Y.; Chen, Vicky P.; MOK, Weng Kei; Cheung, Anna W.H.; BI, Wenchuan
Article

Localization of Proline-Rich Membrane Anchor (PRiMA)-associated acetylcholinesterase in vertebrate neuromuscular junctions

Paper presented at The XIIIth International Symposium on Cholinergic Mechanisms 'Neuronal and Non-Neuronal Cholinergic Systems: Molecular and Translational Significance'
Bi, Wenchuan; Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

Regulation of PRiMA-linked acetylcholinesterase in muscles, neurons and osteoblasts

Paper presented at The XIIIth International Symposium on Cholinergic Mechanisms 'Neuronal and Non-Neuronal Cholinergic Systems: Molecular and Translational Significance', Foz do Iguacu, Brazil
Choi, Chi Yan; Chu, Kin Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

2007 5

Calcitonin gene-related peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle: A distinction in driving two different promoters between fast- and slow-twitch muscle fibers

Journal of Neurochemistry, v. 102, (4), p. 1316-1328
CHOI, Cheuk Yiu; Ting, Annie K.L.; Lau, Faye T.C.; Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Siow, Nina L.; Tsim, Karl W.K.
Article

Regulation of a transcript encoding the proline-rich membrane anchor of globular muscle acetylcholinesterase: The suppressive roles of myogenesis and innervating nerves

Journal of Biological Chemistry, v. 282, (16), p. 11765-11775
Xie, Heidi Q.; CHOI, Cheuk Yiu; LEUNG, Ka Wing; Siow, Nina L.; Kong, Ling W.; Lau, Faye T.C.; Peng, H. Benjamin; Tsim, Karl W.K.
Article

Characterization of proline-rich membrane anchor (PRiMA)-associated acetylcholinesterase in cholinergic synapses

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

Regulation of a transcript encoding the proline-rich membrane anchor of globular muscle acetylcholinesterase: The suppressive roles of myogenesis and innervating nerves

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Massoulie, J.; Tsim, Karl Wah Keung
Conference paper

Regulation of different subunits of acetylcholinesterase expression during the nerve growth factor-induced neuronal differentiation in cultured PC12 cells

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Mok, M.K.W.; Tsim, Karl Wah Keung
Conference paper

2006 3

莪术二酮对ADP诱导的兔血小板聚集的抑制作用

中国药理学通报=Chinese Pharmacological Bulletin, v. 2006, p. 1151-1152
夏泉; 李紹平; 詹華強, Karl Wah Keung; 梁嘉榮, Ka Wing; 董婷霞, Tingxia
Article

Identification and characterization of interacting partners of PRiMA, a membrane anchor of acetylcholinesterase-A proteomic approach

Paper presented at The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS), organized by FAONS, Hong Kong
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

Regulation of Transcript Encoding Proline-rich Membrane Anchor (PRiMA) of Globular form Acetylcholinesterase in Muscle: Suppressive Role of Myogenesis and Innervating Nerve

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Massoulie, J.; Peng, Benjamin H; Tsim, Karl Wah Keung
Conference paper

Article 3

A chemically synthesized resveratrol dimer is a potent inhibitor of vascular endothelial growth factor (VEGF).

Archives of Clinical and Biomedical Research, v. 10, (2), p. 108-116
LIN, Shengying; GUO, Suisui; TANG, Wai Lun; YE, Yutong; HO, Yuen Man; DUAN, Ran; LEUNG, Ka Wing; ZHOU, Jianlong; DONG, Tingxia; TSIM, Karl Wah Keung

From biodiversity to clinical translation: a global review of lichen-derived natural products and their pharmacological potential

Pharmacological Research - Natural Products, v. 10, article number 100456
Yang, Meixia; Lyu, Lisha; Wang, Xinyu; Lin, Shengying; Leung, Ka Wing; Dong, Tina Tingxia; Wang, Lisong; Tsim, Karl Wah Keung

Natural source, chemical classification and medicinal application of the stilbene-type compounds: a review of structural nodification around stilbene scaffold

Molecules, v. 31, (13), article number 2208
Lin, Shengying; Tang, Roy Wai Lun; Duan, Ran; Leung, Ka Wing; Dong, Tina Ting Xia; Tsim, Karl Wah Keung

Article 2

Design, Synthesis, and Biological Evaluations of a Novel Resveratrol-Type Analogue Against VEGF

Molecules, v. 30, (11), article number 2345
LIN, Shengying; GUO, Suisui; TANG, Wai Lun; YE, Yutong; WU, Jiahui; Ho, Yuen Man; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; Tsim, Karl Wah Keung

Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models

Molecules, v. 30, (2), article number 257
LIN, Shengying; TANG, Wai Lun; YE, Yutong; XIA, Chenxi; WU, Jiahui; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; Tsim, Karl Wah Keung

Conference paper 6

Drug screening of flavonoids as potential VEGF inhibitors through computational docking and cell models

Paper presented at 2025年中醫藥學術研討會：傳統中醫藥的新藥開發與現代化 (2025 Symposium of Traditional Chinese Medicine: New Drug Development and Modernization of Traditional Chinese Medicine), , Hong Kong, p. 59
LIN, Shengying; TANG, Wai Lun; YE, Yutong; XIA, Chenxi; WU, Jiahui; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; TSIM, Karl Wah Keung; CHEN, Yicun

PT109 promotes neurogenesis in PC12 cells via p38 pathway activation: therapeutic potential for neurological diseases

Zhu, Jiayu; Gao, Xiong; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Pi, Rongbiao; Tsim, Karl Wah Keung

Recycling of Chinese medicine resources - development of pan-health products

Tsim, Karl Wah Keung; Dong, Tingxia; Leung, Ka Wing; Duan, Ran; Lin, Shengying; Gao, Xiong; Xia, Chenxi; Lai, Wing Sze

Sophoricoside, a phytochemical from Fructus Sophorae, promotes hair growth via activation of M4 muscarinic AChR in dermal papilla cells

Yuen, Ka Wing Gary; Lin, Shengying; Tang, Wai Lun; Ye, Yutong; Xia, Chenxi; Wu, Jiahui; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Tsim, Karl Wah Keung

Stictic acid and nonstictic acid as novel therapeutic agents for inhibiting α-synuclein aggregation in Parkinson’s disease

Gao, Jin; Yang, Meixia; Lin, Shengying; Duan, Ran; Leung, Ka Wing; Dong, Tingxia; Tsim, Karl Wah Keung

Yu Ping Feng San Prevents the Cisplatin- and 5-FU-Induced Multiple-Drug Resistance of Escherichia coli

Ye, Yutong; Wu, Jiahui; Guo, Suisui; Lai, Wing Sze; Leung, Ka Wing; Gao, Jin; Dong, Tingxia; Tsim, Karl Wah Keung

Article 2

Computational Docking as a Tool in Guiding the Drug Design of Rutaecarpine Derivatives as Potential SARS-CoV-2 Inhibitors

Molecules, v. 29, (11), article number 2636
LIN, Shengying; WANG, Xiaoyang; TANG, Wai Lun; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; HO, Sarah Elizabeth; Miller, Andrew L.; Tsim, Karl Wah Keung

The Extracts of Evodiae Fructus and Stephaniae Tetrandrae Radix Show Synergy in Blocking the Entry of SARS-CoV-2

Journal of Alternative Complementary & Integrative Medicine, v. 10, article number 478
Lin, Shengying; Wang, Xiaoyang; Tang, Wai Lun; Leung, Ka Wing; Duan, Ran; Kwong, Trina; Dong, Tingxia; Ho, Sarah Elizabeth; Miller, Andrew Leitch; Tsim, Karl Wah Keung

Article 2

The Ethanol Extract of Evodiae Fructus and Its Ingredient, Rutaecarpine, Inhibit Infection of SARS-CoV-2 and Inflammatory Responses

International journal of molecular sciences, v. 24, (1), article number 762
LIN, Shengying; WANG, Xiaoyang; GUO, Hongsheng; DAI, Niyu; TANG, Wai Lun; LEE, Hung Chun; LEUNG, Ka Wing; DONG, Tingxia; HO, Sarah Elizabeth; Miller, Andrew L.; Tsim, Karl Wah Keung

The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions

Journal of Functional Foods, v. 107, article number 105607
YANG, Meixia; Cheng, Edwin Hok Chi; OSPONDPANT, Dusadee; TUNG, Ka Ki; Wang, Li Song; LIN, Shengying; LAI, Wing Sze; Wu, Qi Yun; XIA, Yingjie; LEUNG, Ka Wing; DUAN, Ran; DONG, Tingxia; Tsim, Karl Wah Keung

Article 4

Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry

Journal of Virology, v. 96, (24)
CHOI, Sheyne Sta. Ana; CHAN, Ho Hin; CHAN, Ching Man; WANG, Xiaoyang; HO, Sarah Elizabeth; LEUNG, Ka Wing; Tsim, Karl W.K.; Miller, Andrew L.

Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae

Phytomedicine, v. 102, article number 154154
WANG, Xiaoyang; LIN, Shengying; TANG, Wai Lun; LEE, Hung Chun; CHAN, Ho Hin; CHOI, Sheyne Sta. Ana; LEUNG, Ka Wing; HO, Sarah Elizabeth; Miller, Andrew L.; Tsim, Karl Wah Keung

Resveratrol, an Inhibitor Binding to VEGF, Restores the Pathology of Abnormal Angiogenesis in Retinopathy of Prematurity (ROP) in Mice: Application by Intravitreal and Topical Instillation

International journal of molecular sciences, v. 23, (12), article number 6455
Hu, Wei Hui; Zhang, Xiao Yong; LEUNG, Ka Wing; DUAN, Ran; DONG, Tingxia; Qin, Qi Wei; Tsim, Karl Wah Keung

The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease

Molecules, v. 27, (12), article number 3806
LIN, Shengying; WANG, Xiaoyang; TANG, Wai Lun; LEE, Hung Chun; CHAN, Ho Hin; CHOI, Sheyne Sta. Ana; DONG, Tingxia; LEUNG, Ka Wing; HO, Sarah Elizabeth; Miller, Andrew L.; Tsim, Karl Wah Keung

Conference paper 2

Identification of Lingnan Chinese Medicines against COVID-19 Infection

Paper presented at Health Research Symposium 2021
Webb, Sarah E; Chan, Ho Hin; Choi, Sheyne Sta. Ana; Lee, Hung Chun; Leung, Ka Wing; Lin, Shengying; Miller, Andrew Leitch; Tang, Wai Lun; Tsim, Karl Wah Keung; Wang, Xiaoyang

Traditional Chinese medicine promotes the anti-inflammatory effect of probiotics in fighting against skin eczema

Paper presented at International Conference of the Modernization of Chinese Medicine & Health Products (ICMCM 2021)
Chen, Yanxian; Dong, Tingxia; Leung, Ka Wing; Tsim, Karl Wah Keung; Zheng, Zhongyu

Article 2

The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats

Phytomedicine, v. 74, article number 152815
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; DONG, Tingxia; Chen, Yicun; Qin, Qi Wei; Tsim, Karl Wah Keung

The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix

Molecules, v. 25, (24), article number 5914
Kong, Xiang Peng; Ren, Hai Qin; Liu, Etta Y.L.; LEUNG, Ka Wing; Guo, Shu Chen; DUAN, Ran; DONG, Tingxia; Tsim, Karl W.K.

Article 2

Danggui buxue tang, a Chinese herbal decoction containing Astragali radix and Angelicae sinensis Radix, modulates mitochondrial bioenergetics in cultured cardiomyoblasts

Frontiers in Pharmacology, v. 10, (JUN), article number 614
KWAN, Kin Leung; HUANG, Yun; LEUNG, Ka Wing; DONG, Tingxia; Tsim, Karl W.K.

Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents

Journal of Ginseng Research, v. 43, (4), p. 517-526
HUANG, Yun; KWAN, Kin Leung; LEUNG, Ka Wing; YAO, Ping; Wang, Huaiyou; DONG, Tingxia; Tsim, Karl Wah Keung

Conference paper 2

Mass spectrometry based omics technology to reveal the effect of herbal decoction in cultured osteoblasts

Paper presented at Unknown Event
KWAN, Kin Leung; WONG, Tin Yan; YU, Xiaodan; LEUNG, Ka Wing; DONG, Tingxia; LAM, Hei Ning; TSIM, Karl Wah Keung

Mass-Spectrometry-Based Omics Technology to Reveal the Effect of Herbal Decoction in Cultured Osteoblasts

Paper presented at Unknown Event
KWAN, Kin Leung; WONG, Tin Yan; YU, Xiaodan; LEUNG, Ka Wing; DONG, Tingxia; LAM, Hei Ning; TSIM, Karl Wah Keung

Article 3

Surveillance of drug abuse in Hong Kong by hair analysis using LC-MS/MS

Drug Testing and Analysis, v. 10, (6), p. 977-983
LEUNG, Ka Wing; WONG, Chun Fai; Ho, Janet Y.M.; Yip, Ada W.S.; CHEUNG, Ka Hei; HO, Ka Lam Karen; DUAN, Ran; Tsim, Karl W.K.

The extracts and major compounds derived from astragali radix alter mitochondrial bioenergetics in cultured cardiomyocytes: Comparison of various polar solvents and compounds

International journal of molecular sciences, v. 19, (6), article number 1574
HUANG, Yun; KWAN, Kin Leung; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; DONG, Tingxia; Tsim, Karl Wah Keung

The yin-yang property of Chinese medicinal herbs relates to chemical composition but not anti-oxidative activity: An illustration using spleen-meridian herbs

Frontiers in Pharmacology, v. 9, (NOV), article number 1304
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; Wang, Long; DONG, Tingxia; Chen, Yicun; Tsim, Karl Wah Keung

Conference paper 2

Comparison of the thermoregulatory effects of spleen-meridian herbs with different herbal properties on yeast induced animal model

Paper presented at Unknown Event
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; WANG, Huai-you; KONG, Xiang-Peng; DONG, Tingxia; CHEN, Yi-Cun; TSIM, Karl Wah Keung

Study on the correlation between “Yin-Yang” nature of spleen-meridian herbs with the chemical composition, antioxidant activity and effects to energy metabolism

Paper presented at International Conference of the Modernization of Chinese Medicine & Health Products (ICMCM) 2018: Inheritance and Innovation - In Commemoration of the 500th Anniversary of the Birth of Li Shizhen, Hong Kong
Wang, Huaiyou; Kong, Xiang-Peng; Dong, Tingxia; Huang, Yun; Leung, Ka Wing; Tsim, Karl Wah Keung; Yao, Ping

Article 2

Determination of hair ketamine cut-off value from Hong Kong ketamine users by LC-MS/MS analysis

Forensic Science International, v. 259, p. 53-58
LEUNG, Ka Wing; WONG, Chun Fai; Ho, Janet Y.M.; Yip, Ada W.S.; Ng, Jenny S.C.; Ip, Stanley P.H.; Ng, Winki Y.Y.; HO, Ka Lam Karen; DUAN, Ran; Zhu, Kevin Y.; Tsim, Karl W.K.

Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species

Pharmaceutica Analytica Acta, v. v. 7, (4), article number 1000474
BI, Dan; ZHANG, L.M.L.; TANG, Wai Lun; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; WONG, Yung Hou; LIN, Huangquan; TSIM, Karl Wah Keung

Article 2

UPLC-MS/MS法測定吸毒者頭發中10種毒品代謝物的含量

药物分析杂志=Chinese Journal of Pharmaceutical Analysis, v. v. 34, p. 516-522
謝, 普; 王, 鐵杰; 殷, 果; 閆, 研; 丁, 振浩; 肖, 麗和; 詹, 華強; 梁, 嘉榮; 李, 璐; 孫, 新珺; 畢, 開順

头发验毒技术和服务平台的研究及应用: 深港创新合作共建头发验毒服务平台( II)

中国药物滥用防治杂志, (20), p. 1-4
谢, 普; 王, 铁杰; 殷, 果; 闫, 研; 丁, 振浩; 肖, 丽和; 詹, 华强; 梁, 嘉荣; 李, 璐; 李, 晓东; 孙, 新珺; 毕, 开顺

Article 3

Isorhamnetin, a flavonol aglycone from Ginkgo biloba L., induces neuronal differentiation of cultured PC12 cells: Potentiating the effect of nerve growth factor

Evidence-based Complementary and Alternative Medicine, v. 2012, article number 278273
XU, Li; CHOI, Cheuk Yiu; Zhu, Kevin Y.; LEUNG, Ka Wing; Guo, Ava J.Y.; Bi, Dan; Xu, Hong; Lau, David T.W.; DONG, Tingxia; Tsim, Karl W.K.

Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair

Analytical and Bioanalytical Chemistry, v. 402, (9), p. 2805-2815
Zhu, Kevin Y.; LEUNG, Ka Wing; Ting, Annie K.L.; WONG, Chun Fai; Ng, Winki Y.Y.; CHOI, Cheuk Yiu; DONG, Tingxia; Wang, Tiejie; Lau, David T.W.; Tsim, Karl W.K.

UPLC-MS /MS 同时测定头发中十种残留毒品含量: 深港创新合作共建头发验毒服务平台

中国药物滥用防治杂志, v. v. 18, (6), p. 317-319
王, 铁杰; 詹, 华强; 孙, 新珺; 肖, 丽和; 殷, 果; 闫, 研; 谢, 普; 丁, 振浩; 梁, 嘉荣; 李, 晓东

Article 3

Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation

Frontiers in Molecular Neuroscience
Chan, Gallant K.L.; Choi, Chi Yan; Leung, K. Wing; Luk, Wilson K.W.; Tsim, Karl Wah Keung; Xu, Sherry L.

The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS

Forensic Science International, v. 208, (1-3), p. 53-58
Zhu, Kevin Y.; LEUNG, Ka Wing; Ting, Annie K.L.; WONG, Chun Fai; Fu, Qiang; Ng, Winki Y.Y.; CHOI, Cheuk Yiu; DONG, Tingxia; Wang, Tiejie; Lau, David T.W.; Tsim, Karl W.K.

The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, v. 879, (11-12), p. 737-742
Zhu, Kevin Y.; Fu, Qiang; LEUNG, Ka Wing; WONG, Chun Fai; CHOI, Cheuk Yiu; Tsim, Karl W.K.

Conference paper 3

A new species of cholinesterase in chicken brain: PRiMA-linked AChE-BChE hybrid tetramer

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chan, GKL; Chen, VP; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung; Zhang, VQ

A novel G-protein-coupled receptor complex: heterodimerization of purinergic P2Y1 and P2Y2 receptors

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chan, GKL; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung

Post-translational modification of PRiMA-linked G4 AChE by glycosylation

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chen, VP; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung; Zhang, VQ

Article 2

Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions - Contribution and expression from motor neurons

FEBS Journal, v. 276, (11), p. 3031-3042
LEUNG, Ka Wing; Xie, Heidi Q.; Chen, Vicky P.; MOK, Weng Kei; Chu, Glanice K.Y.; CHOI, Cheuk Yiu; Tsim, Karl W.K.

Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: An inductive effect of neuron differentiation

Brain Research, v. 1265, p. 13-23
Xie, Heidi Q.; CHOI, Cheuk Yiu; LEUNG, Ka Wing; Chen, Vicky P.; Chu, Glanice K.Y.; Tsim, Karl W.K.

Conference paper 1

The molecular assembly of acetylcholinesterase and butyrylcholinesterase: the formation of PRiMA-linked G4 hybrid

Paper presented at The 6th Asian Biophysics Association (ABA) Symposium organized by the Biophysical Society of Hong Kong and the Hong Kong Society of Neurosciences, Hong Kong
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung

Article 3

Myocyte enhancer factor 2 mediates acetylcholine-induced expression of acetylcholinesterase-associated collagen ColQ in cultured myotubes

Molecular and Cellular Neuroscience, v. 39, (3), p. 429-438
Lau, Faye T.C.; CHOI, Cheuk Yiu; Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Zhu, Judy T.T.; BI, Wenchuan; Chu, Glanice K.Y.; Tsim, Karl W.K.

The promoter activity of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in muscle: Suppressive roles of myogenesis and innervating nerve

Chemico-Biological Interactions, v. 175, (1-3), p. 79-82
Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Lau, Faye T.C.; Liu, Lois S.; CHOI, Cheuk Yiu; Tsim, Karl W.K.

Transcriptional control of different subunits of AChE in muscles: Signals triggered by the motor nerve-derived factors

Chemico-Biological Interactions, v. 175, (1-3), p. 58-63
Tsim, Karl W.K.; CHOI, Cheuk Yiu; Xie, Heidi Q.; Zhu, Judy T.T.; LEUNG, Ka Wing; Lau, Faye T.C.; Chu, Glanice K.Y.; Chen, Vicky P.; MOK, Weng Kei; Cheung, Anna W.H.; BI, Wenchuan

Conference paper 2

Localization of Proline-Rich Membrane Anchor (PRiMA)-associated acetylcholinesterase in vertebrate neuromuscular junctions

Paper presented at The XIIIth International Symposium on Cholinergic Mechanisms 'Neuronal and Non-Neuronal Cholinergic Systems: Molecular and Translational Significance'
Bi, Wenchuan; Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung

Regulation of PRiMA-linked acetylcholinesterase in muscles, neurons and osteoblasts

Paper presented at The XIIIth International Symposium on Cholinergic Mechanisms 'Neuronal and Non-Neuronal Cholinergic Systems: Molecular and Translational Significance', Foz do Iguacu, Brazil
Choi, Chi Yan; Chu, Kin Yan; Leung, Ka Wing; Tsim, Karl Wah Keung

Article 2

Calcitonin gene-related peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle: A distinction in driving two different promoters between fast- and slow-twitch muscle fibers

Journal of Neurochemistry, v. 102, (4), p. 1316-1328
CHOI, Cheuk Yiu; Ting, Annie K.L.; Lau, Faye T.C.; Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Siow, Nina L.; Tsim, Karl W.K.

Regulation of a transcript encoding the proline-rich membrane anchor of globular muscle acetylcholinesterase: The suppressive roles of myogenesis and innervating nerves

Journal of Biological Chemistry, v. 282, (16), p. 11765-11775
Xie, Heidi Q.; CHOI, Cheuk Yiu; LEUNG, Ka Wing; Siow, Nina L.; Kong, Ling W.; Lau, Faye T.C.; Peng, H. Benjamin; Tsim, Karl W.K.

Conference paper 3

Characterization of proline-rich membrane anchor (PRiMA)-associated acetylcholinesterase in cholinergic synapses

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung

Regulation of a transcript encoding the proline-rich membrane anchor of globular muscle acetylcholinesterase: The suppressive roles of myogenesis and innervating nerves

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Massoulie, J.; Tsim, Karl Wah Keung

Regulation of different subunits of acetylcholinesterase expression during the nerve growth factor-induced neuronal differentiation in cultured PC12 cells

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Mok, M.K.W.; Tsim, Karl Wah Keung

Article 1

莪术二酮对ADP诱导的兔血小板聚集的抑制作用

中国药理学通报=Chinese Pharmacological Bulletin, v. 2006, p. 1151-1152
夏泉; 李紹平; 詹華強, Karl Wah Keung; 梁嘉榮, Ka Wing; 董婷霞, Tingxia

Conference paper 2

Identification and characterization of interacting partners of PRiMA, a membrane anchor of acetylcholinesterase-A proteomic approach

Paper presented at The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS), organized by FAONS, Hong Kong
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung

Regulation of Transcript Encoding Proline-rich Membrane Anchor (PRiMA) of Globular form Acetylcholinesterase in Muscle: Suppressive Role of Myogenesis and Innervating Nerve

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Massoulie, J.; Peng, Benjamin H; Tsim, Karl Wah Keung

2020 2

The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats

Phytomedicine, v. 74, article number 152815
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; DONG, Tingxia; Chen, Yicun; Qin, Qi Wei; Tsim, Karl Wah Keung
Article

The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix

Molecules, v. 25, (24), article number 5914
Kong, Xiang Peng; Ren, Hai Qin; Liu, Etta Y.L.; LEUNG, Ka Wing; Guo, Shu Chen; DUAN, Ran; DONG, Tingxia; Tsim, Karl W.K.
Article

2019 4

Danggui buxue tang, a Chinese herbal decoction containing Astragali radix and Angelicae sinensis Radix, modulates mitochondrial bioenergetics in cultured cardiomyoblasts

Frontiers in Pharmacology, v. 10, (JUN), article number 614
KWAN, Kin Leung; HUANG, Yun; LEUNG, Ka Wing; DONG, Tingxia; Tsim, Karl W.K.
Article

Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents

Journal of Ginseng Research, v. 43, (4), p. 517-526
HUANG, Yun; KWAN, Kin Leung; LEUNG, Ka Wing; YAO, Ping; Wang, Huaiyou; DONG, Tingxia; Tsim, Karl Wah Keung
Article

Mass spectrometry based omics technology to reveal the effect of herbal decoction in cultured osteoblasts

Paper presented at Unknown Event
KWAN, Kin Leung; WONG, Tin Yan; YU, Xiaodan; LEUNG, Ka Wing; DONG, Tingxia; LAM, Hei Ning; TSIM, Karl Wah Keung
Conference paper

Mass-Spectrometry-Based Omics Technology to Reveal the Effect of Herbal Decoction in Cultured Osteoblasts

Paper presented at Unknown Event
KWAN, Kin Leung; WONG, Tin Yan; YU, Xiaodan; LEUNG, Ka Wing; DONG, Tingxia; LAM, Hei Ning; TSIM, Karl Wah Keung
Conference paper

2018 5

Surveillance of drug abuse in Hong Kong by hair analysis using LC-MS/MS

Drug Testing and Analysis, v. 10, (6), p. 977-983
LEUNG, Ka Wing; WONG, Chun Fai; Ho, Janet Y.M.; Yip, Ada W.S.; CHEUNG, Ka Hei; HO, Ka Lam Karen; DUAN, Ran; Tsim, Karl W.K.
Article

The extracts and major compounds derived from astragali radix alter mitochondrial bioenergetics in cultured cardiomyocytes: Comparison of various polar solvents and compounds

International journal of molecular sciences, v. 19, (6), article number 1574
HUANG, Yun; KWAN, Kin Leung; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; DONG, Tingxia; Tsim, Karl Wah Keung
Article

The yin-yang property of Chinese medicinal herbs relates to chemical composition but not anti-oxidative activity: An illustration using spleen-meridian herbs

Frontiers in Pharmacology, v. 9, (NOV), article number 1304
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; Wang, Huaiyou; Kong, Xiang Peng; Wang, Long; DONG, Tingxia; Chen, Yicun; Tsim, Karl Wah Keung
Article

Comparison of the thermoregulatory effects of spleen-meridian herbs with different herbal properties on yeast induced animal model

Paper presented at Unknown Event
HUANG, Yun; YAO, Ping; LEUNG, Ka Wing; WANG, Huai-you; KONG, Xiang-Peng; DONG, Tingxia; CHEN, Yi-Cun; TSIM, Karl Wah Keung
Conference paper

Study on the correlation between “Yin-Yang” nature of spleen-meridian herbs with the chemical composition, antioxidant activity and effects to energy metabolism

Paper presented at International Conference of the Modernization of Chinese Medicine & Health Products (ICMCM) 2018: Inheritance and Innovation - In Commemoration of the 500th Anniversary of the Birth of Li Shizhen, Hong Kong
Wang, Huaiyou; Kong, Xiang-Peng; Dong, Tingxia; Huang, Yun; Leung, Ka Wing; Tsim, Karl Wah Keung; Yao, Ping
Conference paper

2016 2

Determination of hair ketamine cut-off value from Hong Kong ketamine users by LC-MS/MS analysis

Forensic Science International, v. 259, p. 53-58
LEUNG, Ka Wing; WONG, Chun Fai; Ho, Janet Y.M.; Yip, Ada W.S.; Ng, Jenny S.C.; Ip, Stanley P.H.; Ng, Winki Y.Y.; HO, Ka Lam Karen; DUAN, Ran; Zhu, Kevin Y.; Tsim, Karl W.K.
Article

Quantitative Analysis of Nucleosides and Nucleobases in Deer Antler: Variation in Different Species

Pharmaceutica Analytica Acta, v. v. 7, (4), article number 1000474
BI, Dan; ZHANG, L.M.L.; TANG, Wai Lun; DUAN, Ran; LEUNG, Ka Wing; DONG, Tingxia; WONG, Yung Hou; LIN, Huangquan; TSIM, Karl Wah Keung
Article

2014 2

UPLC-MS/MS法測定吸毒者頭發中10種毒品代謝物的含量

药物分析杂志=Chinese Journal of Pharmaceutical Analysis, v. v. 34, p. 516-522
謝, 普; 王, 鐵杰; 殷, 果; 閆, 研; 丁, 振浩; 肖, 麗和; 詹, 華強; 梁, 嘉榮; 李, 璐; 孫, 新珺; 畢, 開順
Article

头发验毒技术和服务平台的研究及应用: 深港创新合作共建头发验毒服务平台( II)

中国药物滥用防治杂志, (20), p. 1-4
谢, 普; 王, 铁杰; 殷, 果; 闫, 研; 丁, 振浩; 肖, 丽和; 詹, 华强; 梁, 嘉荣; 李, 璐; 李, 晓东; 孙, 新珺; 毕, 开顺
Article

2012 3

Isorhamnetin, a flavonol aglycone from Ginkgo biloba L., induces neuronal differentiation of cultured PC12 cells: Potentiating the effect of nerve growth factor

Evidence-based Complementary and Alternative Medicine, v. 2012, article number 278273
XU, Li; CHOI, Cheuk Yiu; Zhu, Kevin Y.; LEUNG, Ka Wing; Guo, Ava J.Y.; Bi, Dan; Xu, Hong; Lau, David T.W.; DONG, Tingxia; Tsim, Karl W.K.
Article

Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair

Analytical and Bioanalytical Chemistry, v. 402, (9), p. 2805-2815
Zhu, Kevin Y.; LEUNG, Ka Wing; Ting, Annie K.L.; WONG, Chun Fai; Ng, Winki Y.Y.; CHOI, Cheuk Yiu; DONG, Tingxia; Wang, Tiejie; Lau, David T.W.; Tsim, Karl W.K.
Article

UPLC-MS /MS 同时测定头发中十种残留毒品含量: 深港创新合作共建头发验毒服务平台

中国药物滥用防治杂志, v. v. 18, (6), p. 317-319
王, 铁杰; 詹, 华强; 孙, 新珺; 肖, 丽和; 殷, 果; 闫, 研; 谢, 普; 丁, 振浩; 梁, 嘉荣; 李, 晓东
Article

2011 3

Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation

Frontiers in Molecular Neuroscience
Chan, Gallant K.L.; Choi, Chi Yan; Leung, K. Wing; Luk, Wilson K.W.; Tsim, Karl Wah Keung; Xu, Sherry L.
Article

The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS

Forensic Science International, v. 208, (1-3), p. 53-58
Zhu, Kevin Y.; LEUNG, Ka Wing; Ting, Annie K.L.; WONG, Chun Fai; Fu, Qiang; Ng, Winki Y.Y.; CHOI, Cheuk Yiu; DONG, Tingxia; Wang, Tiejie; Lau, David T.W.; Tsim, Karl W.K.
Article

The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, v. 879, (11-12), p. 737-742
Zhu, Kevin Y.; Fu, Qiang; LEUNG, Ka Wing; WONG, Chun Fai; CHOI, Cheuk Yiu; Tsim, Karl W.K.
Article

2010 3

A new species of cholinesterase in chicken brain: PRiMA-linked AChE-BChE hybrid tetramer

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chan, GKL; Chen, VP; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung; Zhang, VQ
Conference paper

A novel G-protein-coupled receptor complex: heterodimerization of purinergic P2Y1 and P2Y2 receptors

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chan, GKL; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

Post-translational modification of PRiMA-linked G4 AChE by glycosylation

Paper presented at Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong
Chen, VP; Choi, Roy Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung; Zhang, VQ
Conference paper

2009 3

Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions - Contribution and expression from motor neurons

FEBS Journal, v. 276, (11), p. 3031-3042
LEUNG, Ka Wing; Xie, Heidi Q.; Chen, Vicky P.; MOK, Weng Kei; Chu, Glanice K.Y.; CHOI, Cheuk Yiu; Tsim, Karl W.K.
Article

Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: An inductive effect of neuron differentiation

Brain Research, v. 1265, p. 13-23
Xie, Heidi Q.; CHOI, Cheuk Yiu; LEUNG, Ka Wing; Chen, Vicky P.; Chu, Glanice K.Y.; Tsim, Karl W.K.
Article

The molecular assembly of acetylcholinesterase and butyrylcholinesterase: the formation of PRiMA-linked G4 hybrid

Paper presented at The 6th Asian Biophysics Association (ABA) Symposium organized by the Biophysical Society of Hong Kong and the Hong Kong Society of Neurosciences, Hong Kong
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

2008 5

Myocyte enhancer factor 2 mediates acetylcholine-induced expression of acetylcholinesterase-associated collagen ColQ in cultured myotubes

Molecular and Cellular Neuroscience, v. 39, (3), p. 429-438
Lau, Faye T.C.; CHOI, Cheuk Yiu; Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Zhu, Judy T.T.; BI, Wenchuan; Chu, Glanice K.Y.; Tsim, Karl W.K.
Article

The promoter activity of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in muscle: Suppressive roles of myogenesis and innervating nerve

Chemico-Biological Interactions, v. 175, (1-3), p. 79-82
Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Lau, Faye T.C.; Liu, Lois S.; CHOI, Cheuk Yiu; Tsim, Karl W.K.
Article

Transcriptional control of different subunits of AChE in muscles: Signals triggered by the motor nerve-derived factors

Chemico-Biological Interactions, v. 175, (1-3), p. 58-63
Tsim, Karl W.K.; CHOI, Cheuk Yiu; Xie, Heidi Q.; Zhu, Judy T.T.; LEUNG, Ka Wing; Lau, Faye T.C.; Chu, Glanice K.Y.; Chen, Vicky P.; MOK, Weng Kei; Cheung, Anna W.H.; BI, Wenchuan
Article

Localization of Proline-Rich Membrane Anchor (PRiMA)-associated acetylcholinesterase in vertebrate neuromuscular junctions

Paper presented at The XIIIth International Symposium on Cholinergic Mechanisms 'Neuronal and Non-Neuronal Cholinergic Systems: Molecular and Translational Significance'
Bi, Wenchuan; Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

Regulation of PRiMA-linked acetylcholinesterase in muscles, neurons and osteoblasts

Paper presented at The XIIIth International Symposium on Cholinergic Mechanisms 'Neuronal and Non-Neuronal Cholinergic Systems: Molecular and Translational Significance', Foz do Iguacu, Brazil
Choi, Chi Yan; Chu, Kin Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

2007 5

Calcitonin gene-related peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle: A distinction in driving two different promoters between fast- and slow-twitch muscle fibers

Journal of Neurochemistry, v. 102, (4), p. 1316-1328
CHOI, Cheuk Yiu; Ting, Annie K.L.; Lau, Faye T.C.; Xie, Heidi Q.; LEUNG, Ka Wing; Chen, Vicky P.; Siow, Nina L.; Tsim, Karl W.K.
Article

Regulation of a transcript encoding the proline-rich membrane anchor of globular muscle acetylcholinesterase: The suppressive roles of myogenesis and innervating nerves

Journal of Biological Chemistry, v. 282, (16), p. 11765-11775
Xie, Heidi Q.; CHOI, Cheuk Yiu; LEUNG, Ka Wing; Siow, Nina L.; Kong, Ling W.; Lau, Faye T.C.; Peng, H. Benjamin; Tsim, Karl W.K.
Article

Characterization of proline-rich membrane anchor (PRiMA)-associated acetylcholinesterase in cholinergic synapses

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

Regulation of a transcript encoding the proline-rich membrane anchor of globular muscle acetylcholinesterase: The suppressive roles of myogenesis and innervating nerves

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Massoulie, J.; Tsim, Karl Wah Keung
Conference paper

Regulation of different subunits of acetylcholinesterase expression during the nerve growth factor-induced neuronal differentiation in cultured PC12 cells

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Mok, M.K.W.; Tsim, Karl Wah Keung
Conference paper

2006 3

莪术二酮对ADP诱导的兔血小板聚集的抑制作用

中国药理学通报=Chinese Pharmacological Bulletin, v. 2006, p. 1151-1152
夏泉; 李紹平; 詹華強, Karl Wah Keung; 梁嘉榮, Ka Wing; 董婷霞, Tingxia
Article

Identification and characterization of interacting partners of PRiMA, a membrane anchor of acetylcholinesterase-A proteomic approach

Paper presented at The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS), organized by FAONS, Hong Kong
Choi, Chi Yan; Leung, Ka Wing; Tsim, Karl Wah Keung
Conference paper

Regulation of Transcript Encoding Proline-rich Membrane Anchor (PRiMA) of Globular form Acetylcholinesterase in Muscle: Suppressive Role of Myogenesis and Innervating Nerve

Paper presented at Conference Contribution
Choi, Chi Yan; Leung, Ka Wing; Massoulie, J.; Peng, Benjamin H; Tsim, Karl Wah Keung
Conference paper

Teaching Assignment

2026-27 Fall 4 2025-26 Summer 0 2025-26 Spring 0 2025-26 Winter 0 2025-26 Fall 0 2024-25 Summer 0

DRAP5103	Big Data, Artificial Intelligence and Machine Learning in Drug Safety
DRAP6201	Industrial Internship
DRAP6202	Regulatory Affairs Capstone Project
LIFS4220	Modern Food Science and Technology

No Teaching Assignments

Projects

From January 2024 to December 2026

All Projects 2

No Projects.
The Studies of Astrocyte Reprogramming to Dopaminergic Neurons by the Natural Product of Lipoic Acid Derivative PT109 and Its Composition in treating Parkinson’s Disease and Its Mechanism

天然産物硫辛酸衍生物PT109及其組合物原位重編程星形膠質細胞爲多巴胺神經元治療帕金森氏病及其機制研究 Participating

Innovation and Technology Fund, Lee's Pharmaceutical (HK) Ltd.
Project Team (HKUST)
TSIM Karl Wah Keung (Lead)

LEUNG Ka Wing
2023 - 2025
Synergism of Kai-Xin-San, a Chinese Herbal Formula, with Fluoxetine in Relieving Symptoms of Depression and Side Effect: A Mechanistic Analysis Based on the Brain-Gut Axis

基於“腦-腸軸”調控研究中藥開心散與氟西汀聯合用藥抗抑鬱增效減副的作用機制 Participating

Dynamic Star Limited, Innovation and Technology Fund
Project Team (HKUST)
TSIM Karl Wah Keung (Lead)

CHAN Simon Wan

LEUNG Ka Wing
2022 - 2024

Research Interest

Publications

2026 3

2025 8

2024 2

2023 2

2022 4

2021 2

2020 2

2019 4

2018 5

2016 2

2014 2

2012 3

2011 3

2010 3

2009 3

2008 5

2007 5

2006 3

Article 3

Article 2

Conference paper 6

Article 2

Article 2

Article 4

Conference paper 2

Article 2

Article 2

Conference paper 2

Article 3

Conference paper 2

Article 2

Article 2

Article 3

Article 3

Conference paper 3

Article 2

Conference paper 1

Article 3

Conference paper 2

Article 2

Conference paper 3

Article 1

Conference paper 2

2020 2

2019 4

2018 5

2016 2

2014 2

2012 3

2011 3

2010 3

2009 3

2008 5

2007 5

2006 3

Teaching Assignment

Projects

From January 2024 to December 2026

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