Faculty Profiles - PARK Hyo Keun | The Hong Kong University of Science and Technology

Hyo Keun PARK
朴孝根

PhD in Chemical Physics
University of Illinois Urbana-Champaign, 2006

Associate Professor
Division of Life Science
Department of Physics

(852) 2358 7322
hkpark@ust.hk
Room 5452
Personal Web

Google Scholar

fPV6US0AAAAJ

ORCID

0000-0002-2655-4795

Scopus ID

55713623800

Research Interest Publications Projects Teaching Assignment RPG Supervision Space used

Research Interest

Neuroscience
Biophysics
Imaging techniques

Publications

All Years 46 2025 0 2024 3 2023 3 2022 5 2021 4 2020 8 2019 23

2024 3

Altered anterograde axonal transport of mitochondria in cultured striatal neurons of a knock-in mouse model of Huntington's disease

Biochemical and Biophysical Research Communications, v. 691, January 2024, article number 149246
Wu, Chao; Yin, Haoran; Fu, Songdi; Yoo, Hanna; Zhang, Min; Park, Hyo Keun
Article

Altered mitochondrial Ca²⁺ uptake in presynaptic terminals of cultured striatal and cortical neurons from the zQ175 knock-in mouse model of Huntington's disease

Biochemical and Biophysical Research Communications, v. 716, July 2024, article number 150010
Yoo, Hanna; Park, Hyokeun
Article

Myo10 tail is crucial for promoting long filopodia

Journal of Biological Chemistry, v. 300, (1), January 2024, article number 105523
Chen, Xingxiang; Arciola, Jeffrey M.; Lee, Young Il; Wong, Pak Hung Philip; Yin, Haoran; Tao, Quanqing; Jin, Yuqi; Qin, Xianan; Sweeney, H Lee; Park, Hyo Keun
Article

2023 3

Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease

Frontiers in Molecular Neuroscience, v. 16, August 2023, article number 1175522
Xu, Chen; Chen, Sidong; Chen, Xingxiang; Ho, Ka Hei; Park, Chungwon; Yoo, Hanna; Lee, Suk-Ho; Park, Hyo Keun
Article

Nanobead-based single-molecule pulldown for single cells

Heliyon, v. 9, (11), November 2023, article number e22306
Zhao, Qirui; Shen, Yusheng; Li, Xiaofen; Li, Yulin; Tian, Fang; Yu, Xiaojie; Liu, Zhengzhao; Tong, Rongbiao; Park, Hyokeun; Yobas, Levent; Huang, Pingbo
Article

The Antiparallel Coiled-Coil Domain Allows Multiple Forward Step Sizes of Myosin X

The Journal of Physical Chemistry Letters, v. 14, (21), June 2023, p. 4914-4922
Nguyen, Quang Quan; Zhou, Yangbo; Cheng, Man Sze; Qin, Xianan; Cheng, Harry Chun Man; Liu, Xiaoyan; Sweeney, H. Lee; Park, Hyo Keun
Article

2022 5

Alterations of presynaptic proteins in autism spectrum disorder

Frontiers in Molecular Neuroscience, v. 15, 17 November 2022, article number 1062878
Yeo, Xin Yi; Lim, Yi Tang; Chae, Woo Ri; Park, Chungwon; Park, Hyo Keun; Jung, Sangyong
Article

Precise and Long‐Term Tracking of Mitochondria in Neurons using a Bioconjugatable and Photostable AIE Luminogen

Chemical Science, v. 13, (10), February 2022, p. 2965-2970
Park, Hojeong; Niu, Guangle; Wu, Chao; Park, Chungwon; Liu, Haixiang; Park, Hyo Keun; Kwok, Tsz Kin; Zhang, Jing; He, Benzhao; Tang, Benzhong
Article

Single vesicle tracking for studying synaptic vesicle dynamics in small central synapses

Current Opinion in Neurobiology, v. 76, October 2022, article number 102596
Park, Chungwon; Jung, Sangyong; Park, Hyo Keun
Article

α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword

Biomolecules, v. 12, (4), April 2022, article number 507
Tan, Li Yang; Tang, Kwan Hou; Lim, Lynette Yu You; Ong, Jia Xin; Park, Hyo Keun; Jung, Sangyong
Article

Delineating the design features underlying the stepping mechanism of class X myosin

Biophysical Journal, v. 121, (3, Supplement 1), 11 February 2022, p. 262A
Nguyen, Quang Quan; Zhou, Yangbo; Cheng, Man Sze; Qin, Xianan; Cheng, Harry Chun Man; Liu, Xiaoyan; Sweeney, H. Lee; Park, Hyo Keun
Conference paper

2021 4

Analyzing Protein-protein Interactions In Rare Cells Using Microbead-based Single-molecule Pulldown Assay

Lab on a Chip, v. 21, (16), 15 June 2021, p. 3137-3149
Zhao, Qirui; Shen, Yusheng; Li, Xiaofen; Tian, Fang; Yu, Xiaojie; Yobas, Levent; Park, Hyo Keun; Duan, Yuanyuan; Huang, Pingbo
Article

Real-time three-dimensional tracking of single vesicles reveals abnormal motion and pools of synaptic vesicles in neurons of Huntington’s disease mice

iScience, v. 24, (10), October 2021, article number 103181
Chen, Sidong; Yoo, Hanna; Li, Chun Hei; Park, Chungwon; Park, Gyunam; Tan, Li Yang; Jung, Sangyong; Park, Hyo Keun
Article

Simultaneous Real-Time Three-Dimensional Localization and FRET Measurement of Two Distinct Particles

Nano Letters, v. 21, (18), 22 September 2021, p. 7479-7485
Chen, Xingxiang; Liu, Teng; Qin, Xianan; Nguyen, Quang Quan; Lee, Sang Kwon; Lee, Chanwoo; Ren, Yaguang; Chu, Jun; Zhu, Guang; Yoon, Tae-Young; Park, Chan Young; Park, Hyo Keun
Article

Unique dynamics and exocytosis properties of GABAergic synaptic vesicles revealed by three-dimensional single vesicle tracking

Proceedings of the National Academy of Sciences of the United States of America, v. 118, (9), March 2021, article number e2022133118
Park, Chungwon; Chen, Xingxiang; Tian, Chong-Li; Park, Gyu Nam; Chenouard, Nicolas; Lee, Hunki; Yeo, Xin Yi; Jung, Sangyong; Tsien, Richard W.; Bi, Guoqiang; Park, Hyo Keun
Article

2020 8

Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion

Biophysical Journal, v. 118, (1), January 2020, p. 70-84
Qin, Xianan; Liu, Lei; Lee, Sang-kwon; Alsina Lopez, Adolfo; Liu, Teng; Wu, Chao; Park, Hojeong; Yu, Chenglong; Kim, Hajin; Chu, Jun; Triller, Antoine; Tang, Benzhong; Hyeon, Changbong; Park, Chanyoung; Park, Hyo Keun
Article

Mechanical Responses of Breast Cancer Cells to Substrates of Varying Stiffness Revealed by Single-Cell Measurements

The Journal of Physical Chemistry Letters, v. 11, (18), September 2020, p. 7643-7649
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chen, Xingxiang; Yiu, Pak Man; Tsui, Kwan Chui; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun
Article

Simultaneous tracking of two motor domains reveals near simultaneous steps and stutter steps of myosin 10 on actin filament bundles

Biochemical and Biophysical Research Communications, v. 525, (1), April 2020, p. 94-99
Qin, Xianan; Yoo, Hanna; Cheng, Harry Chun Man; Nguyen, Quang Quan; Li, Jing; Liu, Xiaoyan; Prunetti, Laurence; Chen, Xingxiang; Liu, Teng; Sweeney, H. Lee; Park, Hyo Keun
Article

The inactivation domain of STIM1 acts through intramolecular binding to the coiled-coil domain in the resting state

Journal of Cell Science, v. 133, (1), January 2020
Lee, Sang Kwon; Lee, Min-hsun; Jeong, Su Ji; Qin, Xianan; Lee, Ah Reum; Park, Hyo Keun; Park, Chan Young
Article

A novel nanobead-based single-molecule pull-down for cell populations single cells

Zhao, Qirui; Shen, Yusheng; Tian, Fang; Yobas, Levent; Park, Hyo Keun; Huang, Pingbo
Conference paper

Development of simultaneous single-particle tracking and fret measurement

Liu, Teng; Qin, Xianan; Lee, Sang Kwon; Chu, Jun; Park, Chan Young; Park, Hyo Keun
Conference paper

Different Mechanical Responses to Substrate Stiffness between Cancer Cells and Normal Cells

Biophysical Journal, v. 118, (3), February 2020, article number 1227-Pos, p. 249A
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Yan, Caishan; Yiu, Pak Man; Tsui, Kwan Chui; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun
Conference paper

Real-Time Nanometer-Accuracy Tracking of Single Lipid Droplets in Living Cells

Lau, Hoi Man; Park, Hyo Keun
Conference paper

2019 6

Real-time Three-dimensional Tracking of Single Synaptic Vesicles Reveals That Synaptic Vesicles Undergoing Kiss-and-run Fusion Remain Close to Their Original Fusion Site Before Reuse

Biochemical and Biophysical Research Communications, v. 514, (3), June 2019, p. 1004-1008
Qin, Xianan; Tsien, Richard; Park, Hyo Keun
Article

Altered vesicles dynamics in a Huntington’s disease mouse model studied with 3D tracking of single synaptic vesicle in cortical neurons

Chen, Sidong; Park, Chungwon; Park, Hyokeun
Conference paper

Autophagosome Transport in Huntington's Disease

Li, Chun Hei; Park, Hyo Keun
Conference paper

Exocytosis of GABAergic synaptic vesicles tracked by real-time three-dimensional microscopy

Park, Chungwon; Fan, Ching Yeung; Park, Keun Yang; Lee, Cheuk Long Frank; Park, Hyokeun
Conference paper

Mechanical Responses of Cancer Cells to Different Matrices Measured by AFM and FRET

Biophysical Journal, v. 116, (3), February 2019, article number 2633-Pos, p. 531a, Supplement 1
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun
Conference paper

Tracking of Labeled Motor Domains of Single Full-Length Myosin X on Actin Bundles

Biophysical Journal, v. 116, (3, Supplement 1), 15 February 2019, article number 1281-Pos, p. 259a
Qin, Xianan; Cheung, Chun Man; Li, Jing; Yoo, Hanna; Liu, Xiaoyan; Lin, Tianming; Sweeney, H. LEE; Park, Hyo keun
Conference paper

2018 4

Altered synaptic vesicle release and Ca²⁺ influx at single presynaptic terminals of cortical neurons in a knock-in mouse model of huntington's disease

Frontiers in Molecular Neuroscience, v. 11, (478), December 2018
Chen, Sidong; Yu, Chenglong; Li, Chun Hei; Rong, Li; Qin, Xianan; Ryu, Hoon; Park, Hyo Keun
Article

Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease

Scientific Reports, v. 8, December 2018, article number 16976
Yu, Chenglong; Li, Chun Hei; Chen, Sidong; Yoo, Hanna; Qin, Xianan; Park, Hyo Keun
Article

Monitoring the dynamics of cadherin during movement of cancer cells

Tian, Fang; Chen, Sidong; Chu, jun; Wang, liang; Park, Hyo Keun
Conference paper

Subdiffusive Motion of STIM1 at ER Membrane and ER-Plasma Membrane Junction

Biophysical Journal, v. 114, (3), 2 February 2018, p. 94a, Supp. 1
Qin, Xianan; Alsina, adolfo; Lee, sang kwon; Park, chan young; Park, Hyo Keun
Conference paper

2017 3

Real-time Subpixel-Accuracy Tracking of Single Mitochondria in Neurons Reveals Heterogeneous Mitochondrial Motion

Biochemical and Biophysical Research Communications, 5 September 2017
Alsina, Adolfo; Lai, Wu Ming; Wong, Wai Kin; Qin, Xianan; Zhang, Min; Park, Hyo Keun
Article

Altered exocytosis of synaptic vesicles and Ca2+ influx in cortical neurons in a Huntington’s disease mouse studied with real-time imaging of single presynaptic terminals

Yu, Chenglong; Chen, Sidong; Rong, Li; Zhang, Min; Qin, Xianan; Park, Hyo Keun
Conference paper

Mitochondrial Transport Defect in zQ175 Knock-In Mouse Model of Huntington’s Disease

Zhang, Min; Park, Hyo Keun
Conference paper

2016 2

Real-time imaging of single synaptic vesicles in live neurons

Frontiers in Biology, v. 11, (2), April 2016, p. 109-118
Yu, Chenglong; Zhang, Min; Qin, Xianan; Yang, Xiaofeng; Park, Hyokeun
Article

The Myosin X Motor is Optimized for Movement on Actin Bundles

Nature Communications, v. 7, September 2016, article number 12456
Ropars, Virginie; Yang, Zhaohui; Isabet, Tatiana; Blanc, Florian; Zhou, Kaifeng; Lin, Tianming; Liu, Xiaoyan; Hissier, Pascale; Samazan, Frédéric; Amigues, Béatrice; Yang, Eric D.; Park, Hyo Keun; Pylypenko, Olena; Cecchini, Marco; Sindelar, Charles V.; Sweeney, H. Lee; Houdusse, Anne
Article

2012 1

Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode

Science, v. 335, (6074), March 2012, p. 1362-1366
Park, Hyo Keun; Li, Yulong; Tsien, Richard W.
Article

2007 3

How myosin VI coordinates its heads during processive movement

EMBO JOURNAL, v. 26, (11), June 2007, p. 2682-2692
Sweeney, H. Lee; Park, Hyokeun; Zong, Alan B.; Yang, Zhaohui; Selvin, Paul R.; Rosenfeld, Steven S.
Article

Single-molecule fluorescence to study molecular motors

Q. Rev. Biophys, 40, 1, July 2007, p. 87-111
Park, Hyokeun; Toprak, Erdal; Selvin, Paul R.
Article

The unique insert at the end of the myosin VI motor is the sole determinant of directionality

Proc Natl Acad Sci U S A., v. 104, (3), January 2007, p. 778-783
Park, Hyokeun; Li, Anna; Chen, Li-Qiong; Houdusse, Anne; Selvin, Paul R.; Sweeney, H. Lee
Article

2004 3

Full length myosin VI dimerizes and moves processively along actin filaments upon monomerculstering

Mol. Cell, v. 21, (3), 2006, Feb, p. 331-336
Park, Hyokeun; Ramamurthy, Bhagavathi; Safer, Dan; Travaglia, Mirko; Chen, Li-Qiong; Franzini-Armstrong, Clara; Selvin, Paul R.; Sweeney, H. Lee
Article

Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin

Journal of Biological Chemistry, v.279, (36), 2004, Sep, p. 37223-37226
Yildiz, A.; Park, Hyokeun; Safer, Dan; Yang, Zhaohui; Chen, Li-Qiong; Selvin, Paul R.; Sweeney, H. Lee
Article

Nanometer localization of single ReAsH molecules

JOURNAL OF MICROSCOPY-OXFORD, v.216, (3), 2004, Dec, p. 199-205
Park, Hyokeun; Hanson, GT; Duff, SR; Selvin, Paul R.
Article

2003 1

Photoelectron Spectroscopy of s-Triazine Anion Clusters: Polarization-induced Electron Binding in Aza-aromatic Molecule

Journal of Chemical Physics, v.119, (8), 2003, Aug, p.4320-4327
Kim, JH; Song, JK; Park, Hyokeun; Lee, SH; Han, SY; Kim, SK
Article

Article 3

Altered anterograde axonal transport of mitochondria in cultured striatal neurons of a knock-in mouse model of Huntington's disease

Biochemical and Biophysical Research Communications, v. 691, January 2024, article number 149246
Wu, Chao; Yin, Haoran; Fu, Songdi; Yoo, Hanna; Zhang, Min; Park, Hyo Keun

Altered mitochondrial Ca²⁺ uptake in presynaptic terminals of cultured striatal and cortical neurons from the zQ175 knock-in mouse model of Huntington's disease

Biochemical and Biophysical Research Communications, v. 716, July 2024, article number 150010
Yoo, Hanna; Park, Hyokeun

Myo10 tail is crucial for promoting long filopodia

Journal of Biological Chemistry, v. 300, (1), January 2024, article number 105523
Chen, Xingxiang; Arciola, Jeffrey M.; Lee, Young Il; Wong, Pak Hung Philip; Yin, Haoran; Tao, Quanqing; Jin, Yuqi; Qin, Xianan; Sweeney, H Lee; Park, Hyo Keun

Article 3

Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease

Frontiers in Molecular Neuroscience, v. 16, August 2023, article number 1175522
Xu, Chen; Chen, Sidong; Chen, Xingxiang; Ho, Ka Hei; Park, Chungwon; Yoo, Hanna; Lee, Suk-Ho; Park, Hyo Keun

Nanobead-based single-molecule pulldown for single cells

Heliyon, v. 9, (11), November 2023, article number e22306
Zhao, Qirui; Shen, Yusheng; Li, Xiaofen; Li, Yulin; Tian, Fang; Yu, Xiaojie; Liu, Zhengzhao; Tong, Rongbiao; Park, Hyokeun; Yobas, Levent; Huang, Pingbo

The Antiparallel Coiled-Coil Domain Allows Multiple Forward Step Sizes of Myosin X

The Journal of Physical Chemistry Letters, v. 14, (21), June 2023, p. 4914-4922
Nguyen, Quang Quan; Zhou, Yangbo; Cheng, Man Sze; Qin, Xianan; Cheng, Harry Chun Man; Liu, Xiaoyan; Sweeney, H. Lee; Park, Hyo Keun

Article 4

Alterations of presynaptic proteins in autism spectrum disorder

Frontiers in Molecular Neuroscience, v. 15, 17 November 2022, article number 1062878
Yeo, Xin Yi; Lim, Yi Tang; Chae, Woo Ri; Park, Chungwon; Park, Hyo Keun; Jung, Sangyong

Precise and Long‐Term Tracking of Mitochondria in Neurons using a Bioconjugatable and Photostable AIE Luminogen

Chemical Science, v. 13, (10), February 2022, p. 2965-2970
Park, Hojeong; Niu, Guangle; Wu, Chao; Park, Chungwon; Liu, Haixiang; Park, Hyo Keun; Kwok, Tsz Kin; Zhang, Jing; He, Benzhao; Tang, Benzhong

Single vesicle tracking for studying synaptic vesicle dynamics in small central synapses

Current Opinion in Neurobiology, v. 76, October 2022, article number 102596
Park, Chungwon; Jung, Sangyong; Park, Hyo Keun

α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword

Biomolecules, v. 12, (4), April 2022, article number 507
Tan, Li Yang; Tang, Kwan Hou; Lim, Lynette Yu You; Ong, Jia Xin; Park, Hyo Keun; Jung, Sangyong

Conference paper 1

Delineating the design features underlying the stepping mechanism of class X myosin

Biophysical Journal, v. 121, (3, Supplement 1), 11 February 2022, p. 262A
Nguyen, Quang Quan; Zhou, Yangbo; Cheng, Man Sze; Qin, Xianan; Cheng, Harry Chun Man; Liu, Xiaoyan; Sweeney, H. Lee; Park, Hyo Keun

Article 4

Analyzing Protein-protein Interactions In Rare Cells Using Microbead-based Single-molecule Pulldown Assay

Lab on a Chip, v. 21, (16), 15 June 2021, p. 3137-3149
Zhao, Qirui; Shen, Yusheng; Li, Xiaofen; Tian, Fang; Yu, Xiaojie; Yobas, Levent; Park, Hyo Keun; Duan, Yuanyuan; Huang, Pingbo

Real-time three-dimensional tracking of single vesicles reveals abnormal motion and pools of synaptic vesicles in neurons of Huntington’s disease mice

iScience, v. 24, (10), October 2021, article number 103181
Chen, Sidong; Yoo, Hanna; Li, Chun Hei; Park, Chungwon; Park, Gyunam; Tan, Li Yang; Jung, Sangyong; Park, Hyo Keun

Simultaneous Real-Time Three-Dimensional Localization and FRET Measurement of Two Distinct Particles

Nano Letters, v. 21, (18), 22 September 2021, p. 7479-7485
Chen, Xingxiang; Liu, Teng; Qin, Xianan; Nguyen, Quang Quan; Lee, Sang Kwon; Lee, Chanwoo; Ren, Yaguang; Chu, Jun; Zhu, Guang; Yoon, Tae-Young; Park, Chan Young; Park, Hyo Keun

Unique dynamics and exocytosis properties of GABAergic synaptic vesicles revealed by three-dimensional single vesicle tracking

Proceedings of the National Academy of Sciences of the United States of America, v. 118, (9), March 2021, article number e2022133118
Park, Chungwon; Chen, Xingxiang; Tian, Chong-Li; Park, Gyu Nam; Chenouard, Nicolas; Lee, Hunki; Yeo, Xin Yi; Jung, Sangyong; Tsien, Richard W.; Bi, Guoqiang; Park, Hyo Keun

Article 4

Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion

Biophysical Journal, v. 118, (1), January 2020, p. 70-84
Qin, Xianan; Liu, Lei; Lee, Sang-kwon; Alsina Lopez, Adolfo; Liu, Teng; Wu, Chao; Park, Hojeong; Yu, Chenglong; Kim, Hajin; Chu, Jun; Triller, Antoine; Tang, Benzhong; Hyeon, Changbong; Park, Chanyoung; Park, Hyo Keun

Mechanical Responses of Breast Cancer Cells to Substrates of Varying Stiffness Revealed by Single-Cell Measurements

The Journal of Physical Chemistry Letters, v. 11, (18), September 2020, p. 7643-7649
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chen, Xingxiang; Yiu, Pak Man; Tsui, Kwan Chui; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun

Simultaneous tracking of two motor domains reveals near simultaneous steps and stutter steps of myosin 10 on actin filament bundles

Biochemical and Biophysical Research Communications, v. 525, (1), April 2020, p. 94-99
Qin, Xianan; Yoo, Hanna; Cheng, Harry Chun Man; Nguyen, Quang Quan; Li, Jing; Liu, Xiaoyan; Prunetti, Laurence; Chen, Xingxiang; Liu, Teng; Sweeney, H. Lee; Park, Hyo Keun

The inactivation domain of STIM1 acts through intramolecular binding to the coiled-coil domain in the resting state

Journal of Cell Science, v. 133, (1), January 2020
Lee, Sang Kwon; Lee, Min-hsun; Jeong, Su Ji; Qin, Xianan; Lee, Ah Reum; Park, Hyo Keun; Park, Chan Young

Conference paper 4

A novel nanobead-based single-molecule pull-down for cell populations single cells

Zhao, Qirui; Shen, Yusheng; Tian, Fang; Yobas, Levent; Park, Hyo Keun; Huang, Pingbo

Development of simultaneous single-particle tracking and fret measurement

Liu, Teng; Qin, Xianan; Lee, Sang Kwon; Chu, Jun; Park, Chan Young; Park, Hyo Keun

Different Mechanical Responses to Substrate Stiffness between Cancer Cells and Normal Cells

Biophysical Journal, v. 118, (3), February 2020, article number 1227-Pos, p. 249A
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Yan, Caishan; Yiu, Pak Man; Tsui, Kwan Chui; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun

Real-Time Nanometer-Accuracy Tracking of Single Lipid Droplets in Living Cells

Lau, Hoi Man; Park, Hyo Keun

Article 1

Real-time Three-dimensional Tracking of Single Synaptic Vesicles Reveals That Synaptic Vesicles Undergoing Kiss-and-run Fusion Remain Close to Their Original Fusion Site Before Reuse

Biochemical and Biophysical Research Communications, v. 514, (3), June 2019, p. 1004-1008
Qin, Xianan; Tsien, Richard; Park, Hyo Keun

Conference paper 5

Altered vesicles dynamics in a Huntington’s disease mouse model studied with 3D tracking of single synaptic vesicle in cortical neurons

Chen, Sidong; Park, Chungwon; Park, Hyokeun

Autophagosome Transport in Huntington's Disease

Li, Chun Hei; Park, Hyo Keun

Exocytosis of GABAergic synaptic vesicles tracked by real-time three-dimensional microscopy

Park, Chungwon; Fan, Ching Yeung; Park, Keun Yang; Lee, Cheuk Long Frank; Park, Hyokeun

Mechanical Responses of Cancer Cells to Different Matrices Measured by AFM and FRET

Biophysical Journal, v. 116, (3), February 2019, article number 2633-Pos, p. 531a, Supplement 1
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun

Tracking of Labeled Motor Domains of Single Full-Length Myosin X on Actin Bundles

Biophysical Journal, v. 116, (3, Supplement 1), 15 February 2019, article number 1281-Pos, p. 259a
Qin, Xianan; Cheung, Chun Man; Li, Jing; Yoo, Hanna; Liu, Xiaoyan; Lin, Tianming; Sweeney, H. LEE; Park, Hyo keun

Article 2

Altered synaptic vesicle release and Ca²⁺ influx at single presynaptic terminals of cortical neurons in a knock-in mouse model of huntington's disease

Frontiers in Molecular Neuroscience, v. 11, (478), December 2018
Chen, Sidong; Yu, Chenglong; Li, Chun Hei; Rong, Li; Qin, Xianan; Ryu, Hoon; Park, Hyo Keun

Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease

Scientific Reports, v. 8, December 2018, article number 16976
Yu, Chenglong; Li, Chun Hei; Chen, Sidong; Yoo, Hanna; Qin, Xianan; Park, Hyo Keun

Conference paper 2

Monitoring the dynamics of cadherin during movement of cancer cells

Tian, Fang; Chen, Sidong; Chu, jun; Wang, liang; Park, Hyo Keun

Subdiffusive Motion of STIM1 at ER Membrane and ER-Plasma Membrane Junction

Biophysical Journal, v. 114, (3), 2 February 2018, p. 94a, Supp. 1
Qin, Xianan; Alsina, adolfo; Lee, sang kwon; Park, chan young; Park, Hyo Keun

Article 1

Real-time Subpixel-Accuracy Tracking of Single Mitochondria in Neurons Reveals Heterogeneous Mitochondrial Motion

Biochemical and Biophysical Research Communications, 5 September 2017
Alsina, Adolfo; Lai, Wu Ming; Wong, Wai Kin; Qin, Xianan; Zhang, Min; Park, Hyo Keun

Conference paper 2

Altered exocytosis of synaptic vesicles and Ca2+ influx in cortical neurons in a Huntington’s disease mouse studied with real-time imaging of single presynaptic terminals

Yu, Chenglong; Chen, Sidong; Rong, Li; Zhang, Min; Qin, Xianan; Park, Hyo Keun

Mitochondrial Transport Defect in zQ175 Knock-In Mouse Model of Huntington’s Disease

Zhang, Min; Park, Hyo Keun

Article 2

Real-time imaging of single synaptic vesicles in live neurons

Frontiers in Biology, v. 11, (2), April 2016, p. 109-118
Yu, Chenglong; Zhang, Min; Qin, Xianan; Yang, Xiaofeng; Park, Hyokeun

The Myosin X Motor is Optimized for Movement on Actin Bundles

Nature Communications, v. 7, September 2016, article number 12456
Ropars, Virginie; Yang, Zhaohui; Isabet, Tatiana; Blanc, Florian; Zhou, Kaifeng; Lin, Tianming; Liu, Xiaoyan; Hissier, Pascale; Samazan, Frédéric; Amigues, Béatrice; Yang, Eric D.; Park, Hyo Keun; Pylypenko, Olena; Cecchini, Marco; Sindelar, Charles V.; Sweeney, H. Lee; Houdusse, Anne

Article 1

Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode

Science, v. 335, (6074), March 2012, p. 1362-1366
Park, Hyo Keun; Li, Yulong; Tsien, Richard W.

Article 3

How myosin VI coordinates its heads during processive movement

EMBO JOURNAL, v. 26, (11), June 2007, p. 2682-2692
Sweeney, H. Lee; Park, Hyokeun; Zong, Alan B.; Yang, Zhaohui; Selvin, Paul R.; Rosenfeld, Steven S.

Single-molecule fluorescence to study molecular motors

Q. Rev. Biophys, 40, 1, July 2007, p. 87-111
Park, Hyokeun; Toprak, Erdal; Selvin, Paul R.

The unique insert at the end of the myosin VI motor is the sole determinant of directionality

Proc Natl Acad Sci U S A., v. 104, (3), January 2007, p. 778-783
Park, Hyokeun; Li, Anna; Chen, Li-Qiong; Houdusse, Anne; Selvin, Paul R.; Sweeney, H. Lee

Article 3

Full length myosin VI dimerizes and moves processively along actin filaments upon monomerculstering

Mol. Cell, v. 21, (3), 2006, Feb, p. 331-336
Park, Hyokeun; Ramamurthy, Bhagavathi; Safer, Dan; Travaglia, Mirko; Chen, Li-Qiong; Franzini-Armstrong, Clara; Selvin, Paul R.; Sweeney, H. Lee

Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin

Journal of Biological Chemistry, v.279, (36), 2004, Sep, p. 37223-37226
Yildiz, A.; Park, Hyokeun; Safer, Dan; Yang, Zhaohui; Chen, Li-Qiong; Selvin, Paul R.; Sweeney, H. Lee

Nanometer localization of single ReAsH molecules

JOURNAL OF MICROSCOPY-OXFORD, v.216, (3), 2004, Dec, p. 199-205
Park, Hyokeun; Hanson, GT; Duff, SR; Selvin, Paul R.

Article 1

Photoelectron Spectroscopy of s-Triazine Anion Clusters: Polarization-induced Electron Binding in Aza-aromatic Molecule

Journal of Chemical Physics, v.119, (8), 2003, Aug, p.4320-4327
Kim, JH; Song, JK; Park, Hyokeun; Lee, SH; Han, SY; Kim, SK

2019 6

Real-time Three-dimensional Tracking of Single Synaptic Vesicles Reveals That Synaptic Vesicles Undergoing Kiss-and-run Fusion Remain Close to Their Original Fusion Site Before Reuse

Biochemical and Biophysical Research Communications, v. 514, (3), June 2019, p. 1004-1008
Qin, Xianan; Tsien, Richard; Park, Hyo Keun
Article

Altered vesicles dynamics in a Huntington’s disease mouse model studied with 3D tracking of single synaptic vesicle in cortical neurons

Chen, Sidong; Park, Chungwon; Park, Hyokeun
Conference paper

Autophagosome Transport in Huntington's Disease

Li, Chun Hei; Park, Hyo Keun
Conference paper

Exocytosis of GABAergic synaptic vesicles tracked by real-time three-dimensional microscopy

Park, Chungwon; Fan, Ching Yeung; Park, Keun Yang; Lee, Cheuk Long Frank; Park, Hyokeun
Conference paper

Mechanical Responses of Cancer Cells to Different Matrices Measured by AFM and FRET

Biophysical Journal, v. 116, (3), February 2019, article number 2633-Pos, p. 531a, Supplement 1
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun
Conference paper

Tracking of Labeled Motor Domains of Single Full-Length Myosin X on Actin Bundles

Biophysical Journal, v. 116, (3, Supplement 1), 15 February 2019, article number 1281-Pos, p. 259a
Qin, Xianan; Cheung, Chun Man; Li, Jing; Yoo, Hanna; Liu, Xiaoyan; Lin, Tianming; Sweeney, H. LEE; Park, Hyo keun
Conference paper

2018 4

Altered synaptic vesicle release and Ca²⁺ influx at single presynaptic terminals of cortical neurons in a knock-in mouse model of huntington's disease

Frontiers in Molecular Neuroscience, v. 11, (478), December 2018
Chen, Sidong; Yu, Chenglong; Li, Chun Hei; Rong, Li; Qin, Xianan; Ryu, Hoon; Park, Hyo Keun
Article

Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease

Scientific Reports, v. 8, December 2018, article number 16976
Yu, Chenglong; Li, Chun Hei; Chen, Sidong; Yoo, Hanna; Qin, Xianan; Park, Hyo Keun
Article

Monitoring the dynamics of cadherin during movement of cancer cells

Tian, Fang; Chen, Sidong; Chu, jun; Wang, liang; Park, Hyo Keun
Conference paper

Subdiffusive Motion of STIM1 at ER Membrane and ER-Plasma Membrane Junction

Biophysical Journal, v. 114, (3), 2 February 2018, p. 94a, Supp. 1
Qin, Xianan; Alsina, adolfo; Lee, sang kwon; Park, chan young; Park, Hyo Keun
Conference paper

2017 3

Real-time Subpixel-Accuracy Tracking of Single Mitochondria in Neurons Reveals Heterogeneous Mitochondrial Motion

Biochemical and Biophysical Research Communications, 5 September 2017
Alsina, Adolfo; Lai, Wu Ming; Wong, Wai Kin; Qin, Xianan; Zhang, Min; Park, Hyo Keun
Article

Altered exocytosis of synaptic vesicles and Ca2+ influx in cortical neurons in a Huntington’s disease mouse studied with real-time imaging of single presynaptic terminals

Yu, Chenglong; Chen, Sidong; Rong, Li; Zhang, Min; Qin, Xianan; Park, Hyo Keun
Conference paper

Mitochondrial Transport Defect in zQ175 Knock-In Mouse Model of Huntington’s Disease

Zhang, Min; Park, Hyo Keun
Conference paper

2016 2

Real-time imaging of single synaptic vesicles in live neurons

Frontiers in Biology, v. 11, (2), April 2016, p. 109-118
Yu, Chenglong; Zhang, Min; Qin, Xianan; Yang, Xiaofeng; Park, Hyokeun
Article

The Myosin X Motor is Optimized for Movement on Actin Bundles

Nature Communications, v. 7, September 2016, article number 12456
Ropars, Virginie; Yang, Zhaohui; Isabet, Tatiana; Blanc, Florian; Zhou, Kaifeng; Lin, Tianming; Liu, Xiaoyan; Hissier, Pascale; Samazan, Frédéric; Amigues, Béatrice; Yang, Eric D.; Park, Hyo Keun; Pylypenko, Olena; Cecchini, Marco; Sindelar, Charles V.; Sweeney, H. Lee; Houdusse, Anne
Article

2012 1

Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode

Science, v. 335, (6074), March 2012, p. 1362-1366
Park, Hyo Keun; Li, Yulong; Tsien, Richard W.
Article

2007 3

How myosin VI coordinates its heads during processive movement

EMBO JOURNAL, v. 26, (11), June 2007, p. 2682-2692
Sweeney, H. Lee; Park, Hyokeun; Zong, Alan B.; Yang, Zhaohui; Selvin, Paul R.; Rosenfeld, Steven S.
Article

Single-molecule fluorescence to study molecular motors

Q. Rev. Biophys, 40, 1, July 2007, p. 87-111
Park, Hyokeun; Toprak, Erdal; Selvin, Paul R.
Article

The unique insert at the end of the myosin VI motor is the sole determinant of directionality

Proc Natl Acad Sci U S A., v. 104, (3), January 2007, p. 778-783
Park, Hyokeun; Li, Anna; Chen, Li-Qiong; Houdusse, Anne; Selvin, Paul R.; Sweeney, H. Lee
Article

2004 3

Full length myosin VI dimerizes and moves processively along actin filaments upon monomerculstering

Mol. Cell, v. 21, (3), 2006, Feb, p. 331-336
Park, Hyokeun; Ramamurthy, Bhagavathi; Safer, Dan; Travaglia, Mirko; Chen, Li-Qiong; Franzini-Armstrong, Clara; Selvin, Paul R.; Sweeney, H. Lee
Article

Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin

Journal of Biological Chemistry, v.279, (36), 2004, Sep, p. 37223-37226
Yildiz, A.; Park, Hyokeun; Safer, Dan; Yang, Zhaohui; Chen, Li-Qiong; Selvin, Paul R.; Sweeney, H. Lee
Article

Nanometer localization of single ReAsH molecules

JOURNAL OF MICROSCOPY-OXFORD, v.216, (3), 2004, Dec, p. 199-205
Park, Hyokeun; Hanson, GT; Duff, SR; Selvin, Paul R.
Article

2003 1

Photoelectron Spectroscopy of s-Triazine Anion Clusters: Polarization-induced Electron Binding in Aza-aromatic Molecule

Journal of Chemical Physics, v.119, (8), 2003, Aug, p.4320-4327
Kim, JH; Song, JK; Park, Hyokeun; Lee, SH; Han, SY; Kim, SK
Article

No Publications

Teaching Assignment

2024-25 Spring 5 2024-25 Winter 0 2024-25 Fall 11 2023-24 Summer 4 2023-24 Spring 11 2023-24 Winter 0

LIFS3070	Introduction to Biophysical Instrumentation
LIFS6111V	Life Science Postgraduate Student Seminar
MSDM6980	Computational Modeling and Simulation Project
PHYS2010	Introductory Biological Physics
UROP1100O	Undergraduate Research Opportunities Series 1

LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4971	Biochemistry and Cell Biology Project Research I
LIFS5070	Workshops in Biosciences
LIFS5710	Cellular Regulation
LIFS6112H	Current Topics in Neuroscience
PHYS2080	Physics Seminar and Tutorial I
PHYS3090B	Directed Studies in Physics II
PHYS4814	Contemporary Applications of Physics: Medical Physics
UROP1100N	Undergraduate Research Opportunities Series 1
UROP2100N	Undergraduate Research Opportunities Series 2
UROP4100N	Undergraduate Research Opportunities Series 4

UROP1000	Undergraduate Research Opportunities
UROP1100M	Undergraduate Research Opportunities Series 1
UROP2100M	Undergraduate Research Opportunities Series 2
UROP3200	Undergraduate Research Opportunities with Mini-conference Experience

LIFS3070	Introduction to Biophysical Instrumentation
LIFS4910D	Independent Study
LIFS4963	Biotechnology Capstone Project
LIFS4980	Biological Science Project Research II
LIFS4981	Biochemistry and Cell Biology Project Research II
LIFS4983	Biotechnology Project Research II
MSDM6980	Computational Modeling and Simulation Project
PHYS2010	Introductory Biological Physics
PHYS4291	Capstone Research
UROP1100L	Undergraduate Research Opportunities Series 1
UROP2100L	Undergraduate Research Opportunities Series 2

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 15 May 2025)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

CHEN, Yawen
Life Science
ZHANG, Ziyin
Life Science
ZENG, Jiamin
Life Science
YIN, Haoran
Life Science
FU, Songdi
Life Science

Master of Philosophy

AU-YEUNG, Hoi Dik
Life Science
BUI, Truong Son
Physics
JEONG, Hyunsu
Life Science
WU, Chun Pui
Physics
MOON, Woo Jin
Life Science

Graduated RPGs

Doctor of Philosophy

CHEN, Xingxiang
Life Science( Completed in 2024 )
YOO, Hanna
Life Science( Completed in 2024 )
MA, Xiangyu
Physics( Completed in 2023 )
NGUYEN, Quang Quan
Physics( Completed in 2023 )
PARK, Chungwon
Life Science( Completed in 2022 )

Master of Philosophy

HO, Ka Hei
Life Science( Completed in 2024 )
WONG, Pak Hung Philip
Physics( Completed in 2024 )
XU, Chen
Life Science( Completed in 2023 )

Projects

From January 2023 to December 2025

All Projects 4 Leading Projects 3 Participating Projects 1

Investigating the Mechanisms of Single Synaptic Vesicle Recycling Using Real-Time Three-dimensional Nanometer-accuracy Tracking Microscope and Cryo-Electron Tomography

利用納米精度三維實時追蹤顯微成像與冷凍電鏡斷層三維成像技術研究單個突觸囊泡回收機制 Leading

National Natural Science Foundation of China (NSFC) / Research Grants Council (RGC)
Project Team (HKUST)
PARK Hyo Keun (Lead)
2025 -
Investigating the Molecular Mechanisms of the Unique Dynamics and Release of GABAergic Synaptic Vesicles in GABAergic Presynaptic Terminals

研究 GABA 能突觸前末梢中 GABA 能突觸囊泡的獨特動力學和釋放的分子機制 Leading

Germany / Hong Kong Joint Research Scheme
Project Team (HKUST)
PARK Hyo Keun (Lead)
2023 - 2023
Investigating the Exocytosis and Mobility of Single GABAergic Synaptic Vesicles Undergoing Spontaneous Release in Living Neurons Using a Real-time Three-dimensional Nanometer-accuracy Tracking Microscope

使用實時三維納米精度跟蹤顯微鏡研究單個 GABA 能突觸小泡在活神經元中自發釋放的胞吐作用和遷移率 Leading

RGC - General Research Fund
Project Team (HKUST)
PARK Hyo Keun (Lead)
2022 -
Ectopic expression and functional study of full-length human TMC1 in the absence or presence of TMIE

人全長TMC1單獨或和TMIE一起的外源表達和功能研究 Participating

RGC - General Research Fund
Project Team (HKUST)
HUANG Pingbo (Lead)

PARK Hyo Keun
2021 - 2024

Research Interest

Publications

2024 3

2023 3

2022 5

2021 4

2020 8

2019 6

2018 4

2017 3

2016 2

2012 1

2007 3

2004 3

2003 1

Article 3

Article 3

Article 4

Conference paper 1

Article 4

Article 4

Conference paper 4

Article 1

Conference paper 5

Article 2

Conference paper 2

Article 1

Conference paper 2

Article 2

Article 1

Article 3

Article 3

Article 1

2019 6

2018 4

2017 3

2016 2

2012 1

2007 3

2004 3

2003 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 15 May 2025)

Current RPGs

Graduated RPGs

Projects

From January 2023 to December 2025

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