Faculty Profiles - NAKAMURA Hugh | The Hong Kong University of Science and Technology

Hugh NAKAMURA
中村斐有

PhD in Pharmaceutical Sciences
Kyoto University, 2017

Assistant Professor
Department of Chemistry

(852) 3469 2552
hnakamura@ust.hk
Room 4515
Personal Web

Google Scholar

tNbpg5gAAAAJ

ORCID

0000-0001-5475-7883

Scopus ID

57195640894

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Total synthesis of natural products
Complex molecule synthesis
Synthetic organic chemistry
Electrochemistry
Organic chemistry

Publications

All Years 26 2026 3 2025 3 2024 5 2023 1 2022 2 2021 1 2020 11

2026 3

Advances in Zr-Catalyzed Radical Transformations

Beilstein Journal of Organic Chemistry, v. 22, p. 71-87
OGAWA, Hiroshige; NAKAMURA, Hugh
Article

Reprogramming RiPP scaffolds through skeletal editing unlocks chemical space

Chemical Science
Ogawa, Hiroshige; Yu, Longhui; Li, Shangzhao; Nagata, Yuuya; Chan, Tsz Ki; Matsuda, Yudai; Liu, Jing; Li, Yong Xin; Nakamura, Hugh
Article

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie - International Edition, v. 65, (15), article number e26149
Zhang, Jie; Nakamura, Hugh
Article

2025 3

Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr-Catalyzed Dimerization

Angewandte Chemie - International Edition, v. 64, (2), article number e202414295
Yu, Longhui; Ogawa, Hiroshige; Li, Shangzhao; Lam Cheung, Tsoh; Liu, Wenchao; Yan, Dexiu; Matsuda, Yudai; Kobayashi, Yusuke; Guo, Zhihong; Ikeda, Kotaro; Hamlin, Trevor A; Yamazaki, Ken; Qian, Pei-Yuan; Nakamura, Hugh
Article

Fe-electrocatalytic deoxygenative Giese reaction

Nature Communications, v. 16, (1), article number 8379
Yu, Longhui; Li, Shangzhao; Ogawa, Hiroshige; Ma, Yilin; Chen, Qing; Yamazaki, Ken; Nagata, Yuuya; Nakamura, Hugh
Article

Rapid Construction of a Tyr C6–Trp C5′ Linkage: Application in the Total Synthesis of Micitide 982, a Noncanonical Cyclic Peptide

Angewandte Chemie - International Edition, v. 64, (46), p. 1-10, article number e202516053
Ogawa, Hiroshige; Nagata, Yuuya; Chan, Tsz Ki; Matsuda, Yudai; Nakamura, Hugh
Article

2024 5

Atroposelective Total Synthesis of Cihunamide B

Journal of the American Chemical Society, v. 146, (4), p. 2549-2555
Yu, Longhui; Nagata, Yuuya; Nakamura, Hugh
Article

Atroposelective total synthesis of strecintide 839

Tetrahedron Chem, v. 11, article number 100084
OGAWA, Hiroshige; NAKAMURA, Hugh
Article

Hugh Nakamura

Angewandte Chemie (International ed. in English), v. v. 63, article number e202415362
Nakamura, Hugh
Article

Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage

Angewandte Chemie - International Edition, v. 63, (42), article number e202409987
Zhang, Jie; Yu, Longhui; Ogawa, Hiroshige; Nagata, Yuuya; Nakamura, Hugh
Article

Modular, Scalable Total Synthesis of Neopetromin^†

Chinese Journal of Chemistry, v. 42, (23), p. 3023-3028
Ogawa, Hiroshige; Nagata, Yuuya; Nakamura, Hugh
Article

2023 1

Short, Scalable Access to Pyrrovobasine

JACS Au, v. 3, (11), p. 3000-3004
Yu, Longhui; Nakamura, Hugh
Article

2022 2

Atroposelective Total Synthesis of Darobactin A

Journal of the American Chemical Society, v. 144, (32), p. 14458-14462
Lin, You Chen; Schneider, Fabian; Eberle, Kelly J.; Chiodi, Debora; Nakamura, Hugh; Reisberg, Solomon H.; Chen, Jason; Saito, Masato; Baran, Phil S.
Article

アウェーで勝ち抜くためには。

Organometallic News, v. 1, p. 17-18
中村斐有, Hugh
Article

2021 1

Total synthesis of teleocidins B-1-B-4 by redox-relay chain walking (RRCW)

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, v. 79, (4), p. 333-343
Nakamura, Hugh; Yasui, Kosuke; Baran, Phil S.
Article

2020 1

Two-Phase Synthesis of Taxol

Journal of the American Chemical Society, v. 142, (23), p. 10526-10533
Kanda, Yuzuru; Nakamura, Hugh; Umemiya, Shigenobu; Puthukanoori, Ravi Kumar; Murthy Appala, Venkata Ramana; Gaddamanugu, Gopi Krishna; Paraselli, Bheema Rao; Baran, Phil S.
Article

2019 6

11-Step Total Synthesis of Teleocidins B-1-B-4

Journal of the American Chemical Society, v. 141, (4), p. 1494-1497
Nakamura, Hugh; Yasui, Kosuke; Kanda, Yuzuru; Baran, Phil S.
Article

Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition

Chemistry - A European Journal, v. 25, (37), p. 8701-8704
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji
Article

Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

Synlett, v. 30, (20), p. 2253-2257
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji
Article

Electrochemical C(sp ³)-H Fluorination

Synlett, v. 30, (10), p. 1178-1182, article number st-2018-b1827-c
Takahira, Yusuke; Chen, Miao; Kawamata, Yu; Mykhailiuk, Pavel; Nakamura, Hugh; Peters, Byron K.; Reisberg, Solomon H.; Li, Chao; Chen, Longrui; Hoshikawa, Tamaki; Shibuguchi, Tomoyuki; Baran, Phil S.
Article

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Journal of the American Chemical Society, v. 141, (15), p. 6392-6402
Kawamata, Yu; Vantourout, Julien C.; Hickey, David P.; Bai, Peng; Chen, Longrui; Hou, Qinglong; Qiao, Wenhua; Barman, Koushik; Edwards, Martin A.; Garrido-Castro, Alberto F.; Degruyter, Justine N.; Nakamura, Hugh; Knouse, Kyle; Qin, Chuanguang; Clay, Khalyd J.; Bao, Denghui; Li, Chao; Starr, Jeremy T.; Garcia-Irizarry, Carmen; Sach, Neal; White, Henry S.; Neurock, Matthew; Minteer, Shelley D.; Baran, Phil S.
Article

Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

Journal of the American Chemical Society, v. 141, (21), p. 8527-8540
Nakamura, Hugh; Tsukano, Chihiro; Yoshida, Takuma; Yasui, Motohiro; Yokouchi, Shinsuke; Kobayashi, Yusuke; Igarashi, Masayuki; Takemoto, Yoshiji
Article

2017 1

Electrochemically Enabled, Nickel-Catalyzed Amination

Angewandte Chemie - International Edition, v. 56, (42), p. 13088-13093
Li, Chao; Kawamata, Yu; Nakamura, Hugh; Vantourout, Julien C.; Liu, Zhiqing; Hou, Qinglong; Bao, Denghui; Starr, Jeremy T.; Chen, Jinshan; Yan, Ming; Baran, Phil S.
Article

2016 1

Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Organic Letters, v. 18, (9), p. 2300-2303
Nakamura, Hugh; Yoshida, Takuma; Tsukano, Chihiro; Takemoto, Yoshiji
Article

2015 1

Total synthesis of (-)-caprazamycin a

Angewandte Chemie - International Edition, v. 54, (10), p. 3136-3139
Nakamura, Hugh; Tsukano, Chihiro; Yasui, Motohiro; Yokouchi, Shinsuke; Igarashi, Masayuki; Takemoto, Yoshiji
Article

2013 1

Direct nucleophilic addition to N-alkoxyamides

Chemistry - A European Journal, v. 19, (2), p. 678-684
Yanagita, Yuta; Nakamura, Hugh; Shirokane, Kenji; Kurosaki, Yusuke; Sato, Takaaki; Chida, Noritaka
Article

Article 3

Advances in Zr-Catalyzed Radical Transformations

Beilstein Journal of Organic Chemistry, v. 22, p. 71-87
OGAWA, Hiroshige; NAKAMURA, Hugh

Reprogramming RiPP scaffolds through skeletal editing unlocks chemical space

Chemical Science
Ogawa, Hiroshige; Yu, Longhui; Li, Shangzhao; Nagata, Yuuya; Chan, Tsz Ki; Matsuda, Yudai; Liu, Jing; Li, Yong Xin; Nakamura, Hugh

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie - International Edition, v. 65, (15), article number e26149
Zhang, Jie; Nakamura, Hugh

Article 3

Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr-Catalyzed Dimerization

Angewandte Chemie - International Edition, v. 64, (2), article number e202414295
Yu, Longhui; Ogawa, Hiroshige; Li, Shangzhao; Lam Cheung, Tsoh; Liu, Wenchao; Yan, Dexiu; Matsuda, Yudai; Kobayashi, Yusuke; Guo, Zhihong; Ikeda, Kotaro; Hamlin, Trevor A; Yamazaki, Ken; Qian, Pei-Yuan; Nakamura, Hugh

Fe-electrocatalytic deoxygenative Giese reaction

Nature Communications, v. 16, (1), article number 8379
Yu, Longhui; Li, Shangzhao; Ogawa, Hiroshige; Ma, Yilin; Chen, Qing; Yamazaki, Ken; Nagata, Yuuya; Nakamura, Hugh

Rapid Construction of a Tyr C6–Trp C5′ Linkage: Application in the Total Synthesis of Micitide 982, a Noncanonical Cyclic Peptide

Angewandte Chemie - International Edition, v. 64, (46), p. 1-10, article number e202516053
Ogawa, Hiroshige; Nagata, Yuuya; Chan, Tsz Ki; Matsuda, Yudai; Nakamura, Hugh

Article 5

Atroposelective Total Synthesis of Cihunamide B

Journal of the American Chemical Society, v. 146, (4), p. 2549-2555
Yu, Longhui; Nagata, Yuuya; Nakamura, Hugh

Atroposelective total synthesis of strecintide 839

Tetrahedron Chem, v. 11, article number 100084
OGAWA, Hiroshige; NAKAMURA, Hugh

Hugh Nakamura

Angewandte Chemie (International ed. in English), v. v. 63, article number e202415362
Nakamura, Hugh

Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage

Angewandte Chemie - International Edition, v. 63, (42), article number e202409987
Zhang, Jie; Yu, Longhui; Ogawa, Hiroshige; Nagata, Yuuya; Nakamura, Hugh

Modular, Scalable Total Synthesis of Neopetromin^†

Chinese Journal of Chemistry, v. 42, (23), p. 3023-3028
Ogawa, Hiroshige; Nagata, Yuuya; Nakamura, Hugh

Article 1

Short, Scalable Access to Pyrrovobasine

JACS Au, v. 3, (11), p. 3000-3004
Yu, Longhui; Nakamura, Hugh

Article 2

Atroposelective Total Synthesis of Darobactin A

Journal of the American Chemical Society, v. 144, (32), p. 14458-14462
Lin, You Chen; Schneider, Fabian; Eberle, Kelly J.; Chiodi, Debora; Nakamura, Hugh; Reisberg, Solomon H.; Chen, Jason; Saito, Masato; Baran, Phil S.

アウェーで勝ち抜くためには。

Organometallic News, v. 1, p. 17-18
中村斐有, Hugh

Article 1

Total synthesis of teleocidins B-1-B-4 by redox-relay chain walking (RRCW)

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, v. 79, (4), p. 333-343
Nakamura, Hugh; Yasui, Kosuke; Baran, Phil S.

Article 1

Two-Phase Synthesis of Taxol

Journal of the American Chemical Society, v. 142, (23), p. 10526-10533
Kanda, Yuzuru; Nakamura, Hugh; Umemiya, Shigenobu; Puthukanoori, Ravi Kumar; Murthy Appala, Venkata Ramana; Gaddamanugu, Gopi Krishna; Paraselli, Bheema Rao; Baran, Phil S.

Article 6

11-Step Total Synthesis of Teleocidins B-1-B-4

Journal of the American Chemical Society, v. 141, (4), p. 1494-1497
Nakamura, Hugh; Yasui, Kosuke; Kanda, Yuzuru; Baran, Phil S.

Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition

Chemistry - A European Journal, v. 25, (37), p. 8701-8704
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji

Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

Synlett, v. 30, (20), p. 2253-2257
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji

Electrochemical C(sp ³)-H Fluorination

Synlett, v. 30, (10), p. 1178-1182, article number st-2018-b1827-c
Takahira, Yusuke; Chen, Miao; Kawamata, Yu; Mykhailiuk, Pavel; Nakamura, Hugh; Peters, Byron K.; Reisberg, Solomon H.; Li, Chao; Chen, Longrui; Hoshikawa, Tamaki; Shibuguchi, Tomoyuki; Baran, Phil S.

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Journal of the American Chemical Society, v. 141, (15), p. 6392-6402
Kawamata, Yu; Vantourout, Julien C.; Hickey, David P.; Bai, Peng; Chen, Longrui; Hou, Qinglong; Qiao, Wenhua; Barman, Koushik; Edwards, Martin A.; Garrido-Castro, Alberto F.; Degruyter, Justine N.; Nakamura, Hugh; Knouse, Kyle; Qin, Chuanguang; Clay, Khalyd J.; Bao, Denghui; Li, Chao; Starr, Jeremy T.; Garcia-Irizarry, Carmen; Sach, Neal; White, Henry S.; Neurock, Matthew; Minteer, Shelley D.; Baran, Phil S.

Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

Journal of the American Chemical Society, v. 141, (21), p. 8527-8540
Nakamura, Hugh; Tsukano, Chihiro; Yoshida, Takuma; Yasui, Motohiro; Yokouchi, Shinsuke; Kobayashi, Yusuke; Igarashi, Masayuki; Takemoto, Yoshiji

Article 1

Electrochemically Enabled, Nickel-Catalyzed Amination

Angewandte Chemie - International Edition, v. 56, (42), p. 13088-13093
Li, Chao; Kawamata, Yu; Nakamura, Hugh; Vantourout, Julien C.; Liu, Zhiqing; Hou, Qinglong; Bao, Denghui; Starr, Jeremy T.; Chen, Jinshan; Yan, Ming; Baran, Phil S.

Article 1

Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Organic Letters, v. 18, (9), p. 2300-2303
Nakamura, Hugh; Yoshida, Takuma; Tsukano, Chihiro; Takemoto, Yoshiji

Article 1

Total synthesis of (-)-caprazamycin a

Angewandte Chemie - International Edition, v. 54, (10), p. 3136-3139
Nakamura, Hugh; Tsukano, Chihiro; Yasui, Motohiro; Yokouchi, Shinsuke; Igarashi, Masayuki; Takemoto, Yoshiji

Article 1

Direct nucleophilic addition to N-alkoxyamides

Chemistry - A European Journal, v. 19, (2), p. 678-684
Yanagita, Yuta; Nakamura, Hugh; Shirokane, Kenji; Kurosaki, Yusuke; Sato, Takaaki; Chida, Noritaka

2020 1

Two-Phase Synthesis of Taxol

Journal of the American Chemical Society, v. 142, (23), p. 10526-10533
Kanda, Yuzuru; Nakamura, Hugh; Umemiya, Shigenobu; Puthukanoori, Ravi Kumar; Murthy Appala, Venkata Ramana; Gaddamanugu, Gopi Krishna; Paraselli, Bheema Rao; Baran, Phil S.
Article

2019 6

11-Step Total Synthesis of Teleocidins B-1-B-4

Journal of the American Chemical Society, v. 141, (4), p. 1494-1497
Nakamura, Hugh; Yasui, Kosuke; Kanda, Yuzuru; Baran, Phil S.
Article

Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition

Chemistry - A European Journal, v. 25, (37), p. 8701-8704
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji
Article

Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

Synlett, v. 30, (20), p. 2253-2257
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji
Article

Electrochemical C(sp ³)-H Fluorination

Synlett, v. 30, (10), p. 1178-1182, article number st-2018-b1827-c
Takahira, Yusuke; Chen, Miao; Kawamata, Yu; Mykhailiuk, Pavel; Nakamura, Hugh; Peters, Byron K.; Reisberg, Solomon H.; Li, Chao; Chen, Longrui; Hoshikawa, Tamaki; Shibuguchi, Tomoyuki; Baran, Phil S.
Article

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Journal of the American Chemical Society, v. 141, (15), p. 6392-6402
Kawamata, Yu; Vantourout, Julien C.; Hickey, David P.; Bai, Peng; Chen, Longrui; Hou, Qinglong; Qiao, Wenhua; Barman, Koushik; Edwards, Martin A.; Garrido-Castro, Alberto F.; Degruyter, Justine N.; Nakamura, Hugh; Knouse, Kyle; Qin, Chuanguang; Clay, Khalyd J.; Bao, Denghui; Li, Chao; Starr, Jeremy T.; Garcia-Irizarry, Carmen; Sach, Neal; White, Henry S.; Neurock, Matthew; Minteer, Shelley D.; Baran, Phil S.
Article

Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

Journal of the American Chemical Society, v. 141, (21), p. 8527-8540
Nakamura, Hugh; Tsukano, Chihiro; Yoshida, Takuma; Yasui, Motohiro; Yokouchi, Shinsuke; Kobayashi, Yusuke; Igarashi, Masayuki; Takemoto, Yoshiji
Article

2017 1

Electrochemically Enabled, Nickel-Catalyzed Amination

Angewandte Chemie - International Edition, v. 56, (42), p. 13088-13093
Li, Chao; Kawamata, Yu; Nakamura, Hugh; Vantourout, Julien C.; Liu, Zhiqing; Hou, Qinglong; Bao, Denghui; Starr, Jeremy T.; Chen, Jinshan; Yan, Ming; Baran, Phil S.
Article

2016 1

Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Organic Letters, v. 18, (9), p. 2300-2303
Nakamura, Hugh; Yoshida, Takuma; Tsukano, Chihiro; Takemoto, Yoshiji
Article

2015 1

Total synthesis of (-)-caprazamycin a

Angewandte Chemie - International Edition, v. 54, (10), p. 3136-3139
Nakamura, Hugh; Tsukano, Chihiro; Yasui, Motohiro; Yokouchi, Shinsuke; Igarashi, Masayuki; Takemoto, Yoshiji
Article

2013 1

Direct nucleophilic addition to N-alkoxyamides

Chemistry - A European Journal, v. 19, (2), p. 678-684
Yanagita, Yuta; Nakamura, Hugh; Shirokane, Kenji; Kurosaki, Yusuke; Sato, Takaaki; Chida, Noritaka
Article

Teaching Assignment

2025-26 Summer 0 2025-26 Spring 3 2025-26 Winter 0 2025-26 Fall 1 2024-25 Summer 0 2024-25 Spring 1

CHEM4130	Medicinal Chemistry
CHEM4691	Capstone Research I
SCIE2500	Guided Study on Research II

CHEM2110

Organic Chemistry I

CHEM5160

Advanced Medicinal Chemistry

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2023 to December 2026 (As of 20 July 2026)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

LI, Yuxiang
Chemistry
AU, Chak Hin
Chemistry
LIU, Ruoyu
Chemistry
OGAWA, Hiroshige
Chemistry

Master of Philosophy

WU, Xilun
Chemistry

Graduated RPGs

Doctor of Philosophy

ZHANG, Jie
Chemistry( Completed in 2026 )

Projects

From January 2024 to December 2026

All Projects 3

No Projects.
Comprehensive synthesis of geleganidine and related natural products by Fe-electrocatalytic direct conversion of alcohols

通過Fe電催化醇的直接轉化實現Geleganidine及相關天然產物的全面合成 Leading

National Natural Science Foundation of China
Project Team (HKUST)
NAKAMURA Hugh (Lead)
2026 -
Total synthesis of spirocyclic peptides

螺環肽的全合成 Leading

RGC - General Research Fund
Project Team (HKUST)
NAKAMURA Hugh (Lead)
2026 -
Total synthesis of highly strained biaryl-containing cyclic peptides

含雙芳基環肽的高度應變全合成 Leading

RGC - Early Career Scheme
Project Team (HKUST)
NAKAMURA Hugh (Lead)
2024 -

Research Interest

Publications

2026 3

2025 3

2024 5

2023 1

2022 2

2021 1

2020 1

2019 6

2017 1

2016 1

2015 1

2013 1

Article 3

Article 3

Article 5

Article 1

Article 2

Article 1

Article 1

Article 6

Article 1

Article 1

Article 1

Article 1

2020 1

2019 6

2017 1

2016 1

2015 1

2013 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2023 to December 2026 (As of 20 July 2026)

Current RPGs

Graduated RPGs

Projects

From January 2024 to December 2026

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