Faculty Profiles - NAKAMURA Hugh | The Hong Kong University of Science and Technology

Hugh NAKAMURA
中村斐有

PhD in Pharmaceutical Sciences
Kyoto University, 2017

Assistant Professor
Department of Chemistry

(852) 3469 2552
hnakamura@ust.hk
Room 4515
Personal Web

Google Scholar

tNbpg5gAAAAJ

ORCID

0000-0001-5475-7883

Scopus ID

57195640894

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Total synthesis of natural products
Complex molecule synthesis
Synthetic organic chemistry
Electrochemistry
Organic chemistry

Publications

All Years 20 2025 0 2024 5 2023 1 2022 2 2021 1 2020 1 2019 10

2024 5

Atroposelective Total Synthesis of Cihunamide B

Journal of the American Chemical Society, v. 146, (4), January 2024, p. 2549-2555
Yu, Longhui; Nagata, Yuuya; Nakamura, Hugh
Article

Atroposelective total synthesis of strecintide 839

Tetrahedron Chem, v. 11, August 2024, article number 100084, p. 1-6
Ogawa, Hiroshige; Nakamura, Hugh
Article

Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr-Catalyzed Dimerization

Angewandte Chemie International Edition, August 2024, article number e202414295
Yu, Longhui; Ogawa, Hiroshige; Li, Shangzhao; Cheung, Tsoh Lam; Liu, Wenchao; Yan, Dexiu; Matsuda, Yudai; Kobayashi, Yusuke; Guo, Zhihong; Ikeda, Kotaro; Hamlin, Trevor A.; Yamazaki, Ken; Qian, Peiyuan; Nakamura, Hugh
Article

Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage

Angewandte Chemie International Edition, v. 63, (42), October 2024, article number e202409987
Zhang, Jie; Yu, Longhui; Ogawa, Hiroshige; Nagata, Yuuya; Nakamura, Hugh
Article

Modular, Scalable Total Synthesis of Neopetromin†

Chinese Journal of Chemistry, v. 42, (23), December 2024, p. 3023-3028
Ogawa, Hiroshige; Nagata, Yuuya; Nakamura, Hugh
Article

2023 1

Short, Scalable Access to Pyrrovobasine

JACS Au, v. 3, (11), November 2023, p. 3000-3004
Yu, Longhui; Nakamura, Hugh
Article

2022 2

Atroposelective Total Synthesis of Darobactin A

Journal of the American Chemical Society, v. 144, (32), August 2022, p. 14458-14462
Lin, You-Chen; Schneider, Fabian; Eberle, Kelly J.; Chiodi, Debora; Nakamura, Hugh; Reisberg, Solomon H.; Chen, Jason; Saito, Masato; Baran, Phil S.
Article

アウェーで勝ち抜くためには。

Organometallic News, v. 1, March 2022, p. 17-18
中村斐有
Article

2021 1

Redox-Relay Chain WalkingによるTeleocidin B類の全合成

有機合成化学協会誌=Journal of Synthetic Organic Chemistry, v. 79, (4), April 2021, p. 333-343
中村斐有; 安井孝介; Baran, Phil S.
Article

2020 1

Two-Phase Synthesis of Taxol

Journal of the American Chemical Society, v. 142, (23), June 2020, p. 10526-10533
Kanda, Yuzuru; Nakamura, Hugh; Umemiya, Shigenobu; Puthukanoori, Ravi Kumar; Murthy Appala, Venkata Ramana; Gaddamanugu, Gopi Krishna; Paraselli, Bheema Rao; Baran, Phil S.
Article

2019 6

11-Step Total Synthesis of Teleocidins B-1-B-4

Journal of the American Chemical Society, v. 141, (4), January 2019, p. 1494-1497
Nakamura, Hugh; Yasui, Kosuke; Kanda, Yuzuru; Baran, Phil S.
Article

Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition

Chemistry - A European Journal, v. 25, (37), July 2019, p. 8701-8704
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji
Article

Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

Synlett, v. 30, (20), December 2019, p. 2253-2257
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji
Article

Electrochemical C(sp 3)-H Fluorination

Synlett, v. 30, (10), June 2019, article number st-2018-b1827-c, p. 1178-1182
Takahira, Yusuke; Chen, Miao; Kawamata, Yu; Mykhailiuk, Pavel; Nakamura, Hugh; Peters, Byron K.; Reisberg, Solomon H.; Li, Chao; Chen, Longrui; Hoshikawa, Tamaki; Shibuguchi, Tomoyuki; Baran, Phil S.
Article

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Journal of the American Chemical Society, v. 141, (15), April 2019, p. 6392-6402
Nakamura, Hugh; Neurock, Matthew; Minteer, Shelly; Baran, Phil S.
Article

Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

Journal of the American Chemical Society, v. 141, (21), May 2019, p. 8527-8540
Nakamura, Hugh; Tsukano, Chihiro; Yoshida, Takuma; Yasui, Motohiro; Yokouchi, Shinsuke; Kobayashi, Yusuke; Igarashi, Masayuki; Takemoto, Yoshiji
Article

2017 1

Electrochemically Enabled, Nickel-Catalyzed Amination

Angewandte Chemie - International Edition, v. 56, (42), October 2017, p. 13088-13093
Li, Chao; Kawamata, Yu; Nakamura, Hugh; Vantourout, Julien C.; Liu, Zhiqing; Hou, Qinglong; Bao, Denghui; Starr, Jeremy T.; Chen, Jinshan; Yan, Ming; Baran, Phil S.
Article

2016 1

Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Organic Letters, v. 18, (9), May 2016, p. 2300-2303
Nakamura, Hugh; Yoshida, Takuma; Tsukano, Chihiro; Takemoto, Yoshiji
Article

2015 1

Total synthesis of (-)-caprazamycin a

Angewandte Chemie - International Edition, v. 54, (10), March 2015, p. 3136-3139
Nakamura, Hugh; Tsukano, Chihiro; Yasui, Motohiro; Yokouchi, Shinsuke; Igarashi, Masayuki; Takemoto, Yoshiji
Article

2013 1

Direct nucleophilic addition to N-alkoxyamides

Chemistry - A European Journal, v. 19, (2), January 2013, p. 678-684
Yanagita, Yuta; Nakamura, Hugh; Shirokane, Kenji; Kurosaki, Yusuke; Sato, Takaaki; Chida, Noritaka
Article

Article 5

Atroposelective Total Synthesis of Cihunamide B

Journal of the American Chemical Society, v. 146, (4), January 2024, p. 2549-2555
Yu, Longhui; Nagata, Yuuya; Nakamura, Hugh

Atroposelective total synthesis of strecintide 839

Tetrahedron Chem, v. 11, August 2024, article number 100084, p. 1-6
Ogawa, Hiroshige; Nakamura, Hugh

Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr-Catalyzed Dimerization

Angewandte Chemie International Edition, August 2024, article number e202414295
Yu, Longhui; Ogawa, Hiroshige; Li, Shangzhao; Cheung, Tsoh Lam; Liu, Wenchao; Yan, Dexiu; Matsuda, Yudai; Kobayashi, Yusuke; Guo, Zhihong; Ikeda, Kotaro; Hamlin, Trevor A.; Yamazaki, Ken; Qian, Peiyuan; Nakamura, Hugh

Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage

Angewandte Chemie International Edition, v. 63, (42), October 2024, article number e202409987
Zhang, Jie; Yu, Longhui; Ogawa, Hiroshige; Nagata, Yuuya; Nakamura, Hugh

Modular, Scalable Total Synthesis of Neopetromin†

Chinese Journal of Chemistry, v. 42, (23), December 2024, p. 3023-3028
Ogawa, Hiroshige; Nagata, Yuuya; Nakamura, Hugh

Article 1

Short, Scalable Access to Pyrrovobasine

JACS Au, v. 3, (11), November 2023, p. 3000-3004
Yu, Longhui; Nakamura, Hugh

Article 2

Atroposelective Total Synthesis of Darobactin A

Journal of the American Chemical Society, v. 144, (32), August 2022, p. 14458-14462
Lin, You-Chen; Schneider, Fabian; Eberle, Kelly J.; Chiodi, Debora; Nakamura, Hugh; Reisberg, Solomon H.; Chen, Jason; Saito, Masato; Baran, Phil S.

アウェーで勝ち抜くためには。

Organometallic News, v. 1, March 2022, p. 17-18
中村斐有

Article 1

Redox-Relay Chain WalkingによるTeleocidin B類の全合成

有機合成化学協会誌=Journal of Synthetic Organic Chemistry, v. 79, (4), April 2021, p. 333-343
中村斐有; 安井孝介; Baran, Phil S.

Article 1

Two-Phase Synthesis of Taxol

Journal of the American Chemical Society, v. 142, (23), June 2020, p. 10526-10533
Kanda, Yuzuru; Nakamura, Hugh; Umemiya, Shigenobu; Puthukanoori, Ravi Kumar; Murthy Appala, Venkata Ramana; Gaddamanugu, Gopi Krishna; Paraselli, Bheema Rao; Baran, Phil S.

Article 6

11-Step Total Synthesis of Teleocidins B-1-B-4

Journal of the American Chemical Society, v. 141, (4), January 2019, p. 1494-1497
Nakamura, Hugh; Yasui, Kosuke; Kanda, Yuzuru; Baran, Phil S.

Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition

Chemistry - A European Journal, v. 25, (37), July 2019, p. 8701-8704
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji

Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

Synlett, v. 30, (20), December 2019, p. 2253-2257
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji

Electrochemical C(sp 3)-H Fluorination

Synlett, v. 30, (10), June 2019, article number st-2018-b1827-c, p. 1178-1182
Takahira, Yusuke; Chen, Miao; Kawamata, Yu; Mykhailiuk, Pavel; Nakamura, Hugh; Peters, Byron K.; Reisberg, Solomon H.; Li, Chao; Chen, Longrui; Hoshikawa, Tamaki; Shibuguchi, Tomoyuki; Baran, Phil S.

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Journal of the American Chemical Society, v. 141, (15), April 2019, p. 6392-6402
Nakamura, Hugh; Neurock, Matthew; Minteer, Shelly; Baran, Phil S.

Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

Journal of the American Chemical Society, v. 141, (21), May 2019, p. 8527-8540
Nakamura, Hugh; Tsukano, Chihiro; Yoshida, Takuma; Yasui, Motohiro; Yokouchi, Shinsuke; Kobayashi, Yusuke; Igarashi, Masayuki; Takemoto, Yoshiji

Article 1

Electrochemically Enabled, Nickel-Catalyzed Amination

Angewandte Chemie - International Edition, v. 56, (42), October 2017, p. 13088-13093
Li, Chao; Kawamata, Yu; Nakamura, Hugh; Vantourout, Julien C.; Liu, Zhiqing; Hou, Qinglong; Bao, Denghui; Starr, Jeremy T.; Chen, Jinshan; Yan, Ming; Baran, Phil S.

Article 1

Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Organic Letters, v. 18, (9), May 2016, p. 2300-2303
Nakamura, Hugh; Yoshida, Takuma; Tsukano, Chihiro; Takemoto, Yoshiji

Article 1

Total synthesis of (-)-caprazamycin a

Angewandte Chemie - International Edition, v. 54, (10), March 2015, p. 3136-3139
Nakamura, Hugh; Tsukano, Chihiro; Yasui, Motohiro; Yokouchi, Shinsuke; Igarashi, Masayuki; Takemoto, Yoshiji

Article 1

Direct nucleophilic addition to N-alkoxyamides

Chemistry - A European Journal, v. 19, (2), January 2013, p. 678-684
Yanagita, Yuta; Nakamura, Hugh; Shirokane, Kenji; Kurosaki, Yusuke; Sato, Takaaki; Chida, Noritaka

2019 6

11-Step Total Synthesis of Teleocidins B-1-B-4

Journal of the American Chemical Society, v. 141, (4), January 2019, p. 1494-1497
Nakamura, Hugh; Yasui, Kosuke; Kanda, Yuzuru; Baran, Phil S.
Article

Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition

Chemistry - A European Journal, v. 25, (37), July 2019, p. 8701-8704
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji
Article

Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

Synlett, v. 30, (20), December 2019, p. 2253-2257
Nakamura, Hugh; Kawakami, Manami; Tsukano, Chihiro; Takemoto, Yoshiji
Article

Electrochemical C(sp 3)-H Fluorination

Synlett, v. 30, (10), June 2019, article number st-2018-b1827-c, p. 1178-1182
Takahira, Yusuke; Chen, Miao; Kawamata, Yu; Mykhailiuk, Pavel; Nakamura, Hugh; Peters, Byron K.; Reisberg, Solomon H.; Li, Chao; Chen, Longrui; Hoshikawa, Tamaki; Shibuguchi, Tomoyuki; Baran, Phil S.
Article

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Journal of the American Chemical Society, v. 141, (15), April 2019, p. 6392-6402
Nakamura, Hugh; Neurock, Matthew; Minteer, Shelly; Baran, Phil S.
Article

Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

Journal of the American Chemical Society, v. 141, (21), May 2019, p. 8527-8540
Nakamura, Hugh; Tsukano, Chihiro; Yoshida, Takuma; Yasui, Motohiro; Yokouchi, Shinsuke; Kobayashi, Yusuke; Igarashi, Masayuki; Takemoto, Yoshiji
Article

2017 1

Electrochemically Enabled, Nickel-Catalyzed Amination

Angewandte Chemie - International Edition, v. 56, (42), October 2017, p. 13088-13093
Li, Chao; Kawamata, Yu; Nakamura, Hugh; Vantourout, Julien C.; Liu, Zhiqing; Hou, Qinglong; Bao, Denghui; Starr, Jeremy T.; Chen, Jinshan; Yan, Ming; Baran, Phil S.
Article

2016 1

Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Organic Letters, v. 18, (9), May 2016, p. 2300-2303
Nakamura, Hugh; Yoshida, Takuma; Tsukano, Chihiro; Takemoto, Yoshiji
Article

2015 1

Total synthesis of (-)-caprazamycin a

Angewandte Chemie - International Edition, v. 54, (10), March 2015, p. 3136-3139
Nakamura, Hugh; Tsukano, Chihiro; Yasui, Motohiro; Yokouchi, Shinsuke; Igarashi, Masayuki; Takemoto, Yoshiji
Article

2013 1

Direct nucleophilic addition to N-alkoxyamides

Chemistry - A European Journal, v. 19, (2), January 2013, p. 678-684
Yanagita, Yuta; Nakamura, Hugh; Shirokane, Kenji; Kurosaki, Yusuke; Sato, Takaaki; Chida, Noritaka
Article

No Publications

Teaching Assignment

2024-25 Spring 1 2024-25 Winter 0 2024-25 Fall 2 2023-24 Summer 0 2023-24 Spring 3 2023-24 Winter 0

CHEM5160

Advanced Medicinal Chemistry

CHEM2110	Organic Chemistry I
CHEM4689	Capstone Project

CHEM3120	Organic Chemistry II
CHEM4689	Capstone Project
SCIE1500	Guided Study on Research I

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 21 April 2025)

Current RPGs

Doctor of Philosophy

OGAWA, Hiroshige
Chemistry
ZHANG, Jie
Chemistry

Projects

From January 2023 to December 2025

All Projects 2 Leading Projects 1 Participating Projects 1

Total synthesis of highly strained biaryl-containing cyclic peptides

含雙芳基環肽的高度應變全合成 Leading

RGC - Early Career Scheme
Project Team (HKUST)
NAKAMURA Hugh (Lead)
2024 -
Development of novel technique to control immune cell migration in vivo toward understanding of immune cell mediated regeneration process Participating

Japan Agency for Medical Research and Development
Project Team (HKUST)
NAKAMURA Hugh
2022 - 2023

Research Interest

Publications

2024 5

2023 1

2022 2

2021 1

2020 1

2019 6

2017 1

2016 1

2015 1

2013 1

Article 5

Article 1

Article 2

Article 1

Article 1

Article 6

Article 1

Article 1

Article 1

Article 1

2019 6

2017 1

2016 1

2015 1

2013 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 21 April 2025)

Current RPGs

Projects

From January 2023 to December 2025

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