Faculty Profiles - MAK Ho Yi | The Hong Kong University of Science and Technology

2022 2

A Flexible Network of Lipid Droplet Associated Proteins Support Embryonic Integrity of C. elegans

Frontiers in Cell and Developmental Biology, v. 10, 4 April 2022, article number 856474
Cao, Zhe; Fung, Chun Wing; Mak, Ho Yi
Article

Dietary S. maltophilia induces supersized lipid droplets by enhancing lipogenesis and ER-LD contacts in C. elegans

Gut Microbes, v. 14, (1), February 2022, article number 2013762
Xie, Kang; Liu, Yangli; Li, Xixia; Zhang, Hong; Zhang, Shuyan; Mak, Ho Yi; Liu, Pingsheng
Article

2021 2

Are endoplasmic reticulum subdomains shaped by asymmetric distribution of phospholipids? Evidence from a C. elegans model system

BioEssays, v. 43, (1), January 2021, article number 2000199
Cao, Zhe; Wang, Xiaowei; Huang, Xuhui; Mak, Ho Yi
Article

Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans

PLOS Genetics, v. 17, (7), July 2021, article number e1009635
Zeng, Lidan; Li, Xuesong; Preusch, Christopher Brandon; He, Jiawei; Xu, Ningyi; Cheung, Hiu Tung; Qu, Jianan; Mak, Ho Yi
Article

2020 1

Married at Birth: Regulation of Cellular Fat Metabolism by ER–Lipid Droplet Crosstalk

Contact, v. 3, September 2020, p. 1-17
Cao, Zhe; Mak, Ho Yi
Article

2019 2

Dietary Fatty Acids Promote Lipid Droplet Diversity Through Seipin enrichment in an ER subdomain

Nature Communications, v. 10, (1), December 2019, article number 2902
Cao, Zhe; Hao, Yan; Fung, Chun Wing; Lee, Yiu Yiu; Wang, Pengfei; Li, Xuesong; Xie, Kang; Lam, Wen Jiun; Qiu, Yifei; Tang, Benzhong; Shui, Guanghou; Liu, Pingsheng; Qu, Jianan; Kang, Byung-Ho; Mak, Ho Yi
Article

Quantitative Imaging of Lipid Synthesis and Lipolysis Dynamics in Caenorhabditis elegans by Stimulated Raman Scattering Microscopy

Analytical Chemistry, v. 91, (3), February 2019, p. 2279-2287
Li, Xuesong; Li, Yan; Jiang, Meijuan; Wu, Wanjie; He, Sicong; Chen, Congping; Qin, Zhongya; Tang, Benzhong; Mak, Ho Yi; Qu, Jianan
Article

2018 1

In Vivo Study of Lipid Synthesis and Lipolysis Dynamics by Stimulated Raman Scattering Microscopy

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 10498, 2018, article number 104981Q
Li, Xuesong; Liu, Haiyang; He, Sicong; Chen, Congping; Qin, Zhongya; Mak, Ho Yi; Qu, Jianan Y.
Conference paper

2016 2

Determination of lipid droplets heterogeneity by Seipin in C. elegans

Mak, Ho Yi; Qu, Jianan; Liu, Pingsheng; Xie, Kang; Li, Xuesong; Qiu, Yifei; Lam, Wen Jiun; Hao, Yan; Cao, Zhe
Conference paper

Multimodal Nonlinear Optical Imaging of Subcellular Lipid and Vesicular Structures

Proceedings Biomedical Optics 2016, 2016, article number OTh4C.5, art of Biomedical Optics: Meeting Congress 2016
Li, Xuesong; Wen, Jiun Lam; Cao, Zhe; Hao, Yan; Sun, Qiqi; He, Sicong; Mak, Ho Yi; Qu, Jianan
Conference paper

2015 2

Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, v. 1853, (10), October 2015, p. 2481-2491
Na, Huimin; Zhang, Peng; Chen, Yong; Zhu, Xiaotong; Liu, Yi; Liu, Yangli; Xie, Kang; Xu, Ningyi; Yang, Fuquan; Yu, Yong; Cichello, Simon; Mak, Ho Yi; Wang, Meng C.; Zhang, Hong; Liu, Pingsheng
Article

Integrated femtosecond stimulated Raman scattering and two-photon fluorescence imaging of subcellular lipid and vesicular structures

Journal of Biomedical Optics, v. 20, (11), November 2015, article number 110501
Li, Xuesong; Lam, Wenjiun; Cao, Zhe; Hao, Yan; Sun, Qiqi; He, Sicong; Mak, Ho Yi; Qu, Jianan
Article

2014 1

The DEAD Box Helicase RDE-12 Promotes Amplification of RNAi in Cytoplasmic Foci in C. elegans

Current Biology, v. 24, (8), April 2014, p. 832-838
Yang, Huan; Vallandingham, Jim; Shiu, Philip; Li, Hua; Hunter, Craig P.; Mak, Ho Yi
Article

2013 3

A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size

Cell Reports, v. 3, (5), May 2013, p. 1465-1475
Klemm, R.W.; Norton, J.P.; Cole, R.A.; Li, C.S.; Park, S.H.; Crane, M.M.; Li, L.; Jin, D.; Boye-Doe, A.; Liu, T.Y.; Shibata, Y.; Lu, H.; Rapoport, T.A.; Farese, R.V.; Blackstone, C.; Guo, Y.; Mak, H.Y.
Article

C.L.I.P.-continuous live imaging platform for direct observation of C. elegans physiological processes

Lab on a Chip, v. 13, (15), August 2013, p. 2963-2971
Krajniak, Jan; Hao, Yan; Mak, Ho Yi; Lu, Hang
Article

Visualization of Lipid Droplets in c. Elegans by Light and Electron Microscopy

Methods in Cell Biology, v. 116, 2013, p. 39-51
Mak, Ho Yi
Article

2012 3

The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface

The Journal of cell biology, v. 198, (5), September 2012, p. 895-911
Xu, Ningyi; Zhang, Shaobing O.; Cole, Ronald A.; McKinney, Sean A.; Guo, Fengli; Haas, Joel T.; Bobba, Sudheer; Farese, Jr, Robert V.; Mak, Ho Yi
Article

The RDE-10/RDE-11 complex triggers RNAi-induced mRNA degradation by association with target mRNA in C. elegans

Genes & Development, v. 26, (8), April 2012, p. 846-856
Yang, Huan; Zhang, Ying; Vallandingham, Jim; Li, Hau; Florens, Laurence; Mak, Ho Yi
Article

Thematic review series: Lipid droplet synthesis and metabolism: From yeast to man: Lipid droplets as fat storage organelles in Caenorhabditis elegans

Journal of Lipid Research, v. 53, (1), January 2012, p. 28-33
Mak, Ho Yi
Article

2011 1

Nuclear cGMP-Dependent Kinase Regulates Gene Expression via Activity-Dependent Recruitment of a Conserved Histone Deacetylase Complex

PLoS Genetics, v. 7, (5), May 2011, article number e1002065
Hao, Yan; Xu, Ningyi; Box, Andrew C.; Schaefer, Laura; Kannan, Kasthuri; Zhang, Ying; Florens, Laurence; Seidel, Christopher; Washburn, Michael P.; Wiegraebe, Winfried; Mak, Ho Yi
Article

2010 2

Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America, v. 107, (10), March 2010, p. 4640-4645
Zhang, Shaobing O.; Box, Andrew C.; Xu, Ningyi; Le Men, Johan; Yu, Jingyi; Guo, Fengli; Trimble, Rhonda; Mak, Ho Yi
Article

Lipid droplets as ubiquitous fat storage organelles in C. elegans

BMC Cell Biology, v. 11, (96), December 2010
Zhang, Shaobing O.; Trimble, Rhonda; Guo, Fengli; Mak, Ho Yi
Article

2009 1

Biosynthesis of the Caenorhabditis elegans dauer pheromone

Proceedings of the National Academy of Sciences of the United States of America, v. 106, (6), February 2009, p. 1875-1879
Butcher, Rebecca A.; Ragains, Justin R.; Li, Weiqing; Ruvkun, Gary; Clardy, Jon; Mak, Ho Yi
Article

BIBU4850	Biotechnology and Business Project Research
BTEC6900	Case Investigation in Biotechnology
LIFS3370	Human Genetics in Practice
LIFS4960	Biological Science Capstone Project
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4963	Biotechnology Capstone Project
LIFS4981	Biochemistry and Cell Biology Project Research II
LIFS4983	Biotechnology Project Research II
LIFS6115F	Current Topics in Development and Systems Biology
SCIE2500	Guided Study on Research II

LIFS2010	Modern Approaches to Biochemical and Cell Biological Research
LIFS4370	Human Genetics and Personalized Medicine
LIFS4963	Biotechnology Capstone Project
LIFS4971	Biochemistry and Cell Biology Project Research I
LIFS4973	Biotechnology Project Research I

UROP1000	Undergraduate Research Opportunities
UROP1100G	Undergraduate Research Opportunities Series 1

BIBU4850	Biotechnology and Business Project Research
LIFS3370	Human Genetics in Practice
LIFS4960	Biological Science Capstone Project
LIFS4983	Biotechnology Project Research II
LIFS6115E	Current Topics in Development and Systems Biology
SCIE1500	Guided Study on Research I
SCIE2500	Guided Study on Research II

Research Interest

Publications

2022 2

2021 2

2020 1

2019 2

2018 1

2016 2

2015 2

2014 1

2013 3

2012 3

2011 1

2010 2

2009 1

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Article 2

Article 1

Article 2

Conference paper 1

Conference paper 2

Article 2

Article 1

Article 3

Article 3

Article 1

Article 2

Article 1

2016 2

2015 2

2014 1

2013 3

2012 3

2011 1

2010 2

2009 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2020 to December 2023 (As of 31 May 2023)

Current RPGs

Graduated RPGs

Projects

From January 2021 to December 2023

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