Faculty Profiles - WONG Hiu Yi | The Hong Kong University of Science and Technology

Hiu Yi WONG
王曉怡

PhD in Immunology
National University of Singapore, 2019

Research Assistant Professor
Office of the Dean of Medicine

(852) 2358 7279
annawong@ust.hk
Room 5486

ORCID

0000-0002-3255-5073

Scopus ID

59392323400

Research Interest Publications Projects

Research Interest

Neurodegenerative disease
Neuroscience
Immunology

Publications

All Years 39 2026 3 2025 4 2024 0 2023 3 2022 7 2021 1 2020 21

2026 3

Ethnic-specific effects of the LILRB2–LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population

Alzheimer's and Dementia, v. 22, (2), article number e71219
Japanese Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Disease Neuroimaging Initiative; Cao, Han; Zheng, Ziyu; Zhou, Xiaopu; Kikuchi, Masataka; Wong, Hiu Yi; Cheng, Elaine Y.L.; Wong, Bonnie W.Y.; Lo, Ronnie M.N.; Shoai, Maryam; Chong, Joyce R.; Chan, Andrew L.T.; Chen, Christopher; Lam, Linda C.W.; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Chen, Yu; Ip, Fanny C.F.; Mok, Kin Y.; Miyashita, Akinori; Ikeuchi, Takeshi; Hardy, John; Fu, Amy K.Y.; Ip, Nancy Y.
Article

Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification

Proceedings of the National Academy of Sciences of the United States of America, v. 123, (10), article number e2536792123
Jiang, Yuanbing; Zheng, Wenyue; Xia, Zengjie; Wong, Wan Wa; Cheng, Lily K W; Ip, Fanny C; Choi, Siu Man; Chan, Andrew L T; Lam, Ching Yu; Ho, Ka Shing; Shum, Chun Keung; Yuen, Jacqueline K Y; Shea, Yat Fung; Wai, Hok Man; Mok, Vincent C T; Kwok, Timothy C Y; Mok, Kin Y; Wong, Hiu Yi; Zetterberg, Henrik; Fu, Amy K Y; Ip, Nancy Y
Article

Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging

Alzheimer's and Dementia, v. 22, (2), article number e71179
Zheng, Wenyue; Jiang, Yuanbing; Wong, Hiu Yi; Wong, Wan Wa; Cheng, Lily K.W.; Cheng, Elaine Y.L.; Wong, Bonnie W.Y.; Lo, Ronnie M.N.; Leung, Siu Ki; Ip, Fanny C.; Yuen, Jacqueline K.Y.; Shea, Yat Fung; Wong, Wai Ming; Shum, Chun Keung; Wai, Hok Man; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Y.; Heslegrave, Amanda; Hardy, John; Zetterberg, Henrik; Fu, Amy K.Y.; Ip, Nancy Y.
Article

2025 4

Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy

Journal of Neuroinflammation, v. 22, (1), article number 219
Chan, Amanda C.Y.; Huang, Hua; Shah, Ameen; Zhang, Boxuan; Foo, Nicholas W.J.; Li, Ruolin; Mohammad Rizal, Nur Afiqah Binte; Wong, Hiu Yi; Teoh, Hock Luen; Mak, Anselm; Soong, Tuck Wah; Sharma, Vijay K.; Schwarz, Herbert
Article

The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes

Alzheimer's and Dementia, v. 21, (9), article number e70586
Tsui, Jackie Shuk Man; Au, Danise M.; Uhm, Hyebin; Wong, Wan wa; Lo, Ronnie Ming Nok; Jiang, Yuanbing; Ip, Fanny C.F.; Mok, Kin Y.; Wong, Hiu Yi; Kwok, Timothy C.Y.; FU, Kit Yu; Ip, Nancy Y.
Article

Prediction of disease outcomes in Parkinson’s disease using biomarkers

Paper presented at 17th ISNI - International Congress of Neuroimmunology & 5th Global School of Neuroimmunology (GSNI), Chiba, Japan
Au, Danise M.; WONG, Hiu Yi; JIANG, Yuanbing; ZHENG, Wenyue; IP, Fanny Chui Fun; CHENG, Kwan Wai; IP, Wing Ling; CHENG, Yee Ling; Or, Serene HF; Chan, Germaine Hiu Fai; Cheung, Nelson Yuk Fai; MOK, Kin Ying Boniface; FU, Amy Kit Yu; IP, Nancy Yuk-Yu
Conference paper

Use of biomarkers to predict disease outcomes in Parkinson's disease

Paper presented at 9th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress, Japan
Au, Danise M.; WONG, Hiu Yi; CHENG, Kwan Wai; CHENG, Yee Ling; Or, Serene HF; MOK, Kin Ying Boniface; IP, Fanny Chui Fun; See, KWM; Chan, Germaine Hiu Fai; Poon, TL; Cheung, Nelson Yuk Fai; FU, Amy Kit Yu; IP, Nancy Yuk-Yu
Conference paper

2023 3

CD137L, a driver of harmful inflammation in the nervous system

Neural Regeneration Research, v. 18, (11), p. 2387-2388
Wong, Hiu Yi; Chan, Amanda C.Y.; Mak, Anselm; Schwarz, Herbert
Article

Expanding the genetic causes of small-fiber neuropathy: SCN genes and beyond

Muscle and Nerve, v. 67, (4), p. 259-271
Chan, Amanda C.Y.; Kumar, Shivaram; Tan, Grace; Wong, Hiu Yi; Ong, Jonathan J.Y.; Chandra, Bharatendu; Huang, Hua; Sharma, Vijay Kumar; Lai, Poh San
Article

The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology

Nature Aging, v. 3, (10), p. 1219-1236
LAU, Shun Fat; WU, Wei; Wong, Hiu Yi; OUYANG, Li; QIAO, Yi; XU, Jiahui; LAU, Jessica Hiu Yan; Wong, Carlton; JIANG, Yuanbing; Holtzman, David M.; Fu, Amy K.Y.; Ip, Nancy Y.
Article

2022 7

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Nature Aging, v. 2, (7), p. 616-634
Alzheimer’s Disease Neuroimaging Initiative; JIANG, Yuanbing; Zhou, Xiaopu; Wong, Hiu Yi; OUYANG, Li; IP, Fanny Chui Fun; CHAU, Vicky M.N.; LAU, Shun Fat; WU, Wei; WONG, Daniel Y.K.; SEO, Heukjin; FU, Wing Yu; LAI, Nicole C.H.; CHEN, Yuewen; CHEN, Yu; TONG, Estella P.S.; MOK, Kin Ying Boniface; Fu, Amy K.Y.; Ip, Nancy Y.
Article

Asymmetric limb weakness in Guillain-Barré syndrome: A case report

World Journal of Clinical Cases, v. 10, (6), p. 1896-1902
Hu, Ming; Li, Xiang; Wong, Hiu Yi; Feng, Xun Gang; Wang, Yu Zhong; Zhang, Guo Rong
Article

Biomarkers in small fiber neuropathy

Exploration of Neuroprotective Therapy, v. 2, (6), p. 264-283
Chan, Amanda C.Y.; Ong, Kathleen; Ong, Jonathan J.Y.; Sharma, Vijay K.; Wong, Hiu Yi; Vijayan, Joy
Article

Demographics and Medication Use of Patients with Late-Onset Alzheimer's Disease in Hong Kong

Journal of Alzheimer's Disease, v. 87, (3), p. 1205-1213
Wong, Hiu Yi; ZHONG, Huan; ZHONG, Mingqian; Zhou, Xiaopu; CHAN, Yin Cheung Phillip; Kwok, Timothy C.Y.; MOK, Kin Ying Boniface; Hardy, John; IP, Fanny Chui Fun; Fu, Amy K.Y.; Ip, Nancy Y.
Article

Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors

Cancer Immunology, Immunotherapy, v. 71, (11), p. 2583-2596
Prasad, Mukul; Ponnalagu, Sashigala; Zeng, Qun; Luu, Khang; Lang, Si Min; Wong, Hiu Yi; Cheng, Man Si; Wu, Meihui; Mallilankaraman, Karthik; Sobota, Radoslaw Mikolaj; Lim, Yan Ting; Wang, Loo Chien; Goh, Chuan Keng; Tay, Kai Xun Joshua; Loh, Kwok Seng; Wang, Cheng I.; Lee, Wen Hsien; Goh, Boon Cher; Lim, Chwee Ming; Schwarz, Herbert
Article

Novel Autoantibodies in Idiopathic Small Fiber Neuropathy

Annals of Neurology, v. 91, (1), p. 66-77
Chan, Amanda C.Y.; Wong, Hiu Yi; Chong, Yao Feng; Lai, Poh San; Teoh, Hock Luen; Ng, Alison Y.Y.; Hung, Jennifer H.M.; Chan, Yee Cheun; Ng, Kay W.P.; Vijayan, Joy; Ong, Jonathan J.Y.; Chandra, Bharatendu; Tan, Chi Hsien; Rutt, Nurul H.; Tan, Ti Myen; Ismail, Nur Hafiza; Wilder-Smith, Einar; Schwarz, Herbert; Choi, Hyungwon; Sharma, Vijay K.; Mak, Anselm
Article

An IL1RL1 genetic variant lowers soluble ST2 levels and attenuates the impact of APOE-ε4 in Alzheimer's disease

Paper presented at Unknown Event
SEO, Heukjin; JIANG, Yuanbing; ZHOU, Xiaopu; WONG, Hiu Yi; OUYANG, Li; IP, Fanny Chui Fun; CHAU, Man Ni; LAU, Shun Fat; WU, Wei; FU, Wing Yu; LAI, Chit Hang; CHEN, Yuewen; CHEN, Yu; TONG, Pui Sze; Alzheimer's Disease Neuroimaging Initiative; MOK, Vincent C.T.; KWOK, Timothy C. Y.; LEHALLIER, Benoit; LOSADA, Patricia Morán; O'BRIEN, Eleanor; PORTER, Tenielle; LAWS, Simon M.; WYSS-CORAY, Tony; MASTERS, Colin L.; FU, Kit Yu; IP, Nancy Yuk-yu
Conference paper

2021 1

Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting

OncoImmunology, v. 10, (1), article number 1877459
Lee, Kang Yi; Wong, Hiu Yi; Zeng, Qun; Le Lin, Jia; Cheng, Man Si; Kuick, Chik Hong; Chang, Kenneth Tou En; Loh, Amos Hong Pheng; Schwarz, Herbert
Article

2020 2

CD137 / CD137 ligand signalling regulates the immune balance: A potential target for novel immunotherapy of autoimmune diseases

Journal of Autoimmunity, v. 112, article number 102499
Wong, Hiu Yi; Schwarz, Herbert
Article

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand

Frontiers in Immunology, v. 11, article number 571964
Wong, Hiu Yi; Prasad, Ankshita; Gan, Shu Uin; Chua, John Jia En; Schwarz, Herbert
Article

2019 4

Deletion of CD137 ligand exacerbates renal and cutaneous but alleviates cerebral manifestations in Lupus

Frontiers in Immunology, v. 10, (JUN), article number 1411
Mak, Anselm; Dharmadhikari, Bhushan; Kow, Nien Yee; Thamboo, Thomas Paulraj; Tang, Qianqiao; Wong, Lik Wei; Sajikumar, Sreedharan; Wong, Hiu Yi; Schwarz, Herbert
Article

Development of a Bispecific Antibody Targeting CD30 and CD137 on Hodgkin and Reed-Sternberg Cells

Frontiers in Oncology, v. 9, article number 945
Rajendran, Sakthi; Li, Yating; Ngoh, Evelyn; Wong, Hiu Yi; Cheng, Man Si; Wang, Cheng I.; Schwarz, Herbert
Article

Epstein–Barr virus-encoded LMP1 induces ectopic CD137 expression on Hodgkin and Reed–Sternberg cells via the PI3K-AKT-mTOR pathway

Leukemia and Lymphoma, v. 60, (11), p. 2697-2704
Aravinth, Sneha Priya; Rajendran, Sakthi; Li, Yating; Wu, Meihui; Yi Wong, Anna Hiu; Schwarz, Herbert
Article

Induction of CD137 expression by viral genes reduces T cell costimulation

Journal of Cellular Physiology, v. 234, (11), p. 21076-21088
Wu, Meihui; Wong, Hiu Yi; Lin, Jia Le; Moliner, Annalena; Schwarz, Herbert
Article

2018 1

Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome

Muscle and Nerve, v. 57, (2), p. 320-324
Yuki, Nobuhiro; Chan, Amanda C.; Wong, Anna Hiu Yi; Inoue, Takayuki; Yokai, Masafumi; Kurihara, Takashi; Devaux, JérôMe J.; Wilder-Smith, Einar
Article

2016 3

Anti-GQ1b antibody syndrome: Anti-ganglioside complex reactivity determines clinical spectrum

European Journal of Neurology, v. 23, (2), p. 320-326
Fukami, Y.; Wong, A. H.Y.; Funakoshi, K.; Safri, A. Y.; Shahrizaila, N.; Yuki, N.
Article

Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy

Neurology, v. 86, (9), p. 800-807
Devaux, Jérôme J.; Miura, Yumako; Fukami, Yuki; Inoue, Takayuki; Manso, Constance; Belghazi, Maya; Sekiguchi, Kenji; Kokubun, Norito; Ichikawa, Hiroo; Wong, Anna Hiu Yi; Yuki, Nobuhiro
Article

Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy

Journal of Neurology, Neurosurgery and Psychiatry, v. 87, (3), March 2016, p. 275-279
Wong, Hiu Yi; Fukami, Yuki; Sudo, Makoto; Kokubun, Norito; Hamada, Shinsuke; Yuki, Nobuhiro
Article

2015 9

Action mechanism of corticosteroids to aggravate Guillain-Barré syndrome

Scientific Reports, v. 5, article number 13931
Wang, Yu Zhong; Lv, Hui; Shi, Qi Guang; Fan, Xu Tao; Li, Lei; Wong, Anna Hiu Yi; Hao, Yan Lei; Si, Chuan Ping; Li, Cui Lan; Yuki, Nobuhiro
Article

Autoimmune inflammatory neuropathies: Updates in pathogenesis, diagnosis, and treatment

Current Opinion in Neurology, v. 28, (5), p. 468-473
Yi Wong, Anna Hiu; Yuki, Nobuhiro
Article

Chronic inflammatory demyelinating polyneuropathy with membranous nephropathy

Journal of the Peripheral Nervous System, v. 20, (1), p. 63-66
Wong, Anna Hiu Yi; Kokubun, Norito; Fukami, Yuki; Miyaji, Kazuki; Yuki, Nobuhiro
Article

Contactin 1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia

Brain, v. 138, (6), p. 1484-1491
CNTN1-CIDP Study Group; Miura, Yumako; Devaux, Jérôme J.; Fukami, Yuki; Manso, Constance; Belghazi, Maya; Wong, Anna Hiu Yi; Yuki, Nobuhiro; Fujimura, Harutoshi; Fukutake, Toshio; Iwanami, Hisatake; Kusaka, Hirohumi; Kuwabara, Satoshi; Okuma, Yasuyuki; Ueda, Mitsuharu; Yamamoto, Toru
Article

Cytoalbuminologic dissociation in Asian patients with Guillain-Barré and Miller Fisher syndromes

Journal of the Peripheral Nervous System, v. 20, (1), p. 47-51
Wong, Anna Hiu Yi; Umapathi, Thirugnanam; Nishimoto, Yukihiro; Wang, Yu Zhong; Chan, Yee Cheun; Yuki, Nobuhiro
Article

Guillain-Barre syndrome: Advances in pathogenic understanding and diagnostic improvements

Expert Opinion on Orphan Drugs, v. 3, (7), p. 809-819
Wong, Anna Hiu Yi; Yuki, Nobuhiro
Article

Intravenous immunoglobulin may reduce relapse frequency in neuromyelitis optica

Journal of Neuroimmunology, v. 282, p. 92-96
Viswanathan, Shanthi; Wong, Anna H.Y.; Quek, Amy M.L.; Yuki, Nobuhiro
Article

Miller Fisher Syndrome is a nodo-paranodopathy, but not a myelinopathy

Future Neurology, v. 10, (1), p. 15-24
Yi Wong, Anna Hiu; Yuki, Nobuhiro
Article

Telephone and teleradiology-guided thrombolysis can achieve similar outcome as thrombolysis by neurologist on-site

Journal of Stroke and Cerebrovascular Diseases, v. 24, (6), p. 1223-1228
Fong, Wing Chi; Ismail, Moamina; Lo, Joyce Wai Ting; Li, Jessica Tsz Ching; Wong, Anna Hiu Yi; Ng, Yee Wah; Chan, Phillip Yin Cheung; Chan, Andrew Lung Tat; Chan, Germaine Hiu Fai; Fong, Ka Wing; Cheung, Nelson Yuk Fai; Wong, Gordon Chi Keung; Ho, Hiu Fai; Chan, Shun Tim; Kwok, Vivian Wai Yan; Yuen, Bernard Man Kam; Chan, John Hiu Ming; Li, Patrick Chung Ki
Article

2014 2

Letter corresponding to the article 'Insights into antibody-associated encephalitis' by Dr Merwick et al.

Journal of the Neurological Sciences, v. 341, (1-2), p. 172
Wong, Anna Hiu Yi; Wilder-Smith, Einar; Yuki, Nobuhiro
Article

The value of comparing mortality of Guillain-Barré syndrome across different regions

Journal of the Neurological Sciences, v. 344, (1-2), p. 60-62
Wong, A. H.Y.; Umapathi, T.; Shahrizaila, N.; Chan, Y. C.; Kokubun, N.; Fong, M. K.; Chu, Y. P.; Lau, P. K.; Yuki, N.
Article

Article 3

Ethnic-specific effects of the LILRB2–LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population

Alzheimer's and Dementia, v. 22, (2), article number e71219
Japanese Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Disease Neuroimaging Initiative; Cao, Han; Zheng, Ziyu; Zhou, Xiaopu; Kikuchi, Masataka; Wong, Hiu Yi; Cheng, Elaine Y.L.; Wong, Bonnie W.Y.; Lo, Ronnie M.N.; Shoai, Maryam; Chong, Joyce R.; Chan, Andrew L.T.; Chen, Christopher; Lam, Linda C.W.; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Chen, Yu; Ip, Fanny C.F.; Mok, Kin Y.; Miyashita, Akinori; Ikeuchi, Takeshi; Hardy, John; Fu, Amy K.Y.; Ip, Nancy Y.

Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification

Proceedings of the National Academy of Sciences of the United States of America, v. 123, (10), article number e2536792123
Jiang, Yuanbing; Zheng, Wenyue; Xia, Zengjie; Wong, Wan Wa; Cheng, Lily K W; Ip, Fanny C; Choi, Siu Man; Chan, Andrew L T; Lam, Ching Yu; Ho, Ka Shing; Shum, Chun Keung; Yuen, Jacqueline K Y; Shea, Yat Fung; Wai, Hok Man; Mok, Vincent C T; Kwok, Timothy C Y; Mok, Kin Y; Wong, Hiu Yi; Zetterberg, Henrik; Fu, Amy K Y; Ip, Nancy Y

Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging

Alzheimer's and Dementia, v. 22, (2), article number e71179
Zheng, Wenyue; Jiang, Yuanbing; Wong, Hiu Yi; Wong, Wan Wa; Cheng, Lily K.W.; Cheng, Elaine Y.L.; Wong, Bonnie W.Y.; Lo, Ronnie M.N.; Leung, Siu Ki; Ip, Fanny C.; Yuen, Jacqueline K.Y.; Shea, Yat Fung; Wong, Wai Ming; Shum, Chun Keung; Wai, Hok Man; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Y.; Heslegrave, Amanda; Hardy, John; Zetterberg, Henrik; Fu, Amy K.Y.; Ip, Nancy Y.

Article 2

Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy

Journal of Neuroinflammation, v. 22, (1), article number 219
Chan, Amanda C.Y.; Huang, Hua; Shah, Ameen; Zhang, Boxuan; Foo, Nicholas W.J.; Li, Ruolin; Mohammad Rizal, Nur Afiqah Binte; Wong, Hiu Yi; Teoh, Hock Luen; Mak, Anselm; Soong, Tuck Wah; Sharma, Vijay K.; Schwarz, Herbert

The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes

Alzheimer's and Dementia, v. 21, (9), article number e70586
Tsui, Jackie Shuk Man; Au, Danise M.; Uhm, Hyebin; Wong, Wan wa; Lo, Ronnie Ming Nok; Jiang, Yuanbing; Ip, Fanny C.F.; Mok, Kin Y.; Wong, Hiu Yi; Kwok, Timothy C.Y.; FU, Kit Yu; Ip, Nancy Y.

Conference paper 2

Prediction of disease outcomes in Parkinson’s disease using biomarkers

Paper presented at 17th ISNI - International Congress of Neuroimmunology & 5th Global School of Neuroimmunology (GSNI), Chiba, Japan
Au, Danise M.; WONG, Hiu Yi; JIANG, Yuanbing; ZHENG, Wenyue; IP, Fanny Chui Fun; CHENG, Kwan Wai; IP, Wing Ling; CHENG, Yee Ling; Or, Serene HF; Chan, Germaine Hiu Fai; Cheung, Nelson Yuk Fai; MOK, Kin Ying Boniface; FU, Amy Kit Yu; IP, Nancy Yuk-Yu

Use of biomarkers to predict disease outcomes in Parkinson's disease

Paper presented at 9th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress, Japan
Au, Danise M.; WONG, Hiu Yi; CHENG, Kwan Wai; CHENG, Yee Ling; Or, Serene HF; MOK, Kin Ying Boniface; IP, Fanny Chui Fun; See, KWM; Chan, Germaine Hiu Fai; Poon, TL; Cheung, Nelson Yuk Fai; FU, Amy Kit Yu; IP, Nancy Yuk-Yu

Article 3

CD137L, a driver of harmful inflammation in the nervous system

Neural Regeneration Research, v. 18, (11), p. 2387-2388
Wong, Hiu Yi; Chan, Amanda C.Y.; Mak, Anselm; Schwarz, Herbert

Expanding the genetic causes of small-fiber neuropathy: SCN genes and beyond

Muscle and Nerve, v. 67, (4), p. 259-271
Chan, Amanda C.Y.; Kumar, Shivaram; Tan, Grace; Wong, Hiu Yi; Ong, Jonathan J.Y.; Chandra, Bharatendu; Huang, Hua; Sharma, Vijay Kumar; Lai, Poh San

The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology

Nature Aging, v. 3, (10), p. 1219-1236
LAU, Shun Fat; WU, Wei; Wong, Hiu Yi; OUYANG, Li; QIAO, Yi; XU, Jiahui; LAU, Jessica Hiu Yan; Wong, Carlton; JIANG, Yuanbing; Holtzman, David M.; Fu, Amy K.Y.; Ip, Nancy Y.

Article 6

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Nature Aging, v. 2, (7), p. 616-634
Alzheimer’s Disease Neuroimaging Initiative; JIANG, Yuanbing; Zhou, Xiaopu; Wong, Hiu Yi; OUYANG, Li; IP, Fanny Chui Fun; CHAU, Vicky M.N.; LAU, Shun Fat; WU, Wei; WONG, Daniel Y.K.; SEO, Heukjin; FU, Wing Yu; LAI, Nicole C.H.; CHEN, Yuewen; CHEN, Yu; TONG, Estella P.S.; MOK, Kin Ying Boniface; Fu, Amy K.Y.; Ip, Nancy Y.

Asymmetric limb weakness in Guillain-Barré syndrome: A case report

World Journal of Clinical Cases, v. 10, (6), p. 1896-1902
Hu, Ming; Li, Xiang; Wong, Hiu Yi; Feng, Xun Gang; Wang, Yu Zhong; Zhang, Guo Rong

Biomarkers in small fiber neuropathy

Exploration of Neuroprotective Therapy, v. 2, (6), p. 264-283
Chan, Amanda C.Y.; Ong, Kathleen; Ong, Jonathan J.Y.; Sharma, Vijay K.; Wong, Hiu Yi; Vijayan, Joy

Demographics and Medication Use of Patients with Late-Onset Alzheimer's Disease in Hong Kong

Journal of Alzheimer's Disease, v. 87, (3), p. 1205-1213
Wong, Hiu Yi; ZHONG, Huan; ZHONG, Mingqian; Zhou, Xiaopu; CHAN, Yin Cheung Phillip; Kwok, Timothy C.Y.; MOK, Kin Ying Boniface; Hardy, John; IP, Fanny Chui Fun; Fu, Amy K.Y.; Ip, Nancy Y.

Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors

Cancer Immunology, Immunotherapy, v. 71, (11), p. 2583-2596
Prasad, Mukul; Ponnalagu, Sashigala; Zeng, Qun; Luu, Khang; Lang, Si Min; Wong, Hiu Yi; Cheng, Man Si; Wu, Meihui; Mallilankaraman, Karthik; Sobota, Radoslaw Mikolaj; Lim, Yan Ting; Wang, Loo Chien; Goh, Chuan Keng; Tay, Kai Xun Joshua; Loh, Kwok Seng; Wang, Cheng I.; Lee, Wen Hsien; Goh, Boon Cher; Lim, Chwee Ming; Schwarz, Herbert

Novel Autoantibodies in Idiopathic Small Fiber Neuropathy

Annals of Neurology, v. 91, (1), p. 66-77
Chan, Amanda C.Y.; Wong, Hiu Yi; Chong, Yao Feng; Lai, Poh San; Teoh, Hock Luen; Ng, Alison Y.Y.; Hung, Jennifer H.M.; Chan, Yee Cheun; Ng, Kay W.P.; Vijayan, Joy; Ong, Jonathan J.Y.; Chandra, Bharatendu; Tan, Chi Hsien; Rutt, Nurul H.; Tan, Ti Myen; Ismail, Nur Hafiza; Wilder-Smith, Einar; Schwarz, Herbert; Choi, Hyungwon; Sharma, Vijay K.; Mak, Anselm

Conference paper 1

An IL1RL1 genetic variant lowers soluble ST2 levels and attenuates the impact of APOE-ε4 in Alzheimer's disease

Paper presented at Unknown Event
SEO, Heukjin; JIANG, Yuanbing; ZHOU, Xiaopu; WONG, Hiu Yi; OUYANG, Li; IP, Fanny Chui Fun; CHAU, Man Ni; LAU, Shun Fat; WU, Wei; FU, Wing Yu; LAI, Chit Hang; CHEN, Yuewen; CHEN, Yu; TONG, Pui Sze; Alzheimer's Disease Neuroimaging Initiative; MOK, Vincent C.T.; KWOK, Timothy C. Y.; LEHALLIER, Benoit; LOSADA, Patricia Morán; O'BRIEN, Eleanor; PORTER, Tenielle; LAWS, Simon M.; WYSS-CORAY, Tony; MASTERS, Colin L.; FU, Kit Yu; IP, Nancy Yuk-yu

Article 1

Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting

OncoImmunology, v. 10, (1), article number 1877459
Lee, Kang Yi; Wong, Hiu Yi; Zeng, Qun; Le Lin, Jia; Cheng, Man Si; Kuick, Chik Hong; Chang, Kenneth Tou En; Loh, Amos Hong Pheng; Schwarz, Herbert

Article 2

CD137 / CD137 ligand signalling regulates the immune balance: A potential target for novel immunotherapy of autoimmune diseases

Journal of Autoimmunity, v. 112, article number 102499
Wong, Hiu Yi; Schwarz, Herbert

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand

Frontiers in Immunology, v. 11, article number 571964
Wong, Hiu Yi; Prasad, Ankshita; Gan, Shu Uin; Chua, John Jia En; Schwarz, Herbert

Article 4

Deletion of CD137 ligand exacerbates renal and cutaneous but alleviates cerebral manifestations in Lupus

Frontiers in Immunology, v. 10, (JUN), article number 1411
Mak, Anselm; Dharmadhikari, Bhushan; Kow, Nien Yee; Thamboo, Thomas Paulraj; Tang, Qianqiao; Wong, Lik Wei; Sajikumar, Sreedharan; Wong, Hiu Yi; Schwarz, Herbert

Development of a Bispecific Antibody Targeting CD30 and CD137 on Hodgkin and Reed-Sternberg Cells

Frontiers in Oncology, v. 9, article number 945
Rajendran, Sakthi; Li, Yating; Ngoh, Evelyn; Wong, Hiu Yi; Cheng, Man Si; Wang, Cheng I.; Schwarz, Herbert

Epstein–Barr virus-encoded LMP1 induces ectopic CD137 expression on Hodgkin and Reed–Sternberg cells via the PI3K-AKT-mTOR pathway

Leukemia and Lymphoma, v. 60, (11), p. 2697-2704
Aravinth, Sneha Priya; Rajendran, Sakthi; Li, Yating; Wu, Meihui; Yi Wong, Anna Hiu; Schwarz, Herbert

Induction of CD137 expression by viral genes reduces T cell costimulation

Journal of Cellular Physiology, v. 234, (11), p. 21076-21088
Wu, Meihui; Wong, Hiu Yi; Lin, Jia Le; Moliner, Annalena; Schwarz, Herbert

Article 1

Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome

Muscle and Nerve, v. 57, (2), p. 320-324
Yuki, Nobuhiro; Chan, Amanda C.; Wong, Anna Hiu Yi; Inoue, Takayuki; Yokai, Masafumi; Kurihara, Takashi; Devaux, JérôMe J.; Wilder-Smith, Einar

Article 3

Anti-GQ1b antibody syndrome: Anti-ganglioside complex reactivity determines clinical spectrum

European Journal of Neurology, v. 23, (2), p. 320-326
Fukami, Y.; Wong, A. H.Y.; Funakoshi, K.; Safri, A. Y.; Shahrizaila, N.; Yuki, N.

Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy

Neurology, v. 86, (9), p. 800-807
Devaux, Jérôme J.; Miura, Yumako; Fukami, Yuki; Inoue, Takayuki; Manso, Constance; Belghazi, Maya; Sekiguchi, Kenji; Kokubun, Norito; Ichikawa, Hiroo; Wong, Anna Hiu Yi; Yuki, Nobuhiro

Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy

Journal of Neurology, Neurosurgery and Psychiatry, v. 87, (3), March 2016, p. 275-279
Wong, Hiu Yi; Fukami, Yuki; Sudo, Makoto; Kokubun, Norito; Hamada, Shinsuke; Yuki, Nobuhiro

Article 9

Action mechanism of corticosteroids to aggravate Guillain-Barré syndrome

Scientific Reports, v. 5, article number 13931
Wang, Yu Zhong; Lv, Hui; Shi, Qi Guang; Fan, Xu Tao; Li, Lei; Wong, Anna Hiu Yi; Hao, Yan Lei; Si, Chuan Ping; Li, Cui Lan; Yuki, Nobuhiro

Autoimmune inflammatory neuropathies: Updates in pathogenesis, diagnosis, and treatment

Current Opinion in Neurology, v. 28, (5), p. 468-473
Yi Wong, Anna Hiu; Yuki, Nobuhiro

Chronic inflammatory demyelinating polyneuropathy with membranous nephropathy

Journal of the Peripheral Nervous System, v. 20, (1), p. 63-66
Wong, Anna Hiu Yi; Kokubun, Norito; Fukami, Yuki; Miyaji, Kazuki; Yuki, Nobuhiro

Contactin 1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia

Brain, v. 138, (6), p. 1484-1491
CNTN1-CIDP Study Group; Miura, Yumako; Devaux, Jérôme J.; Fukami, Yuki; Manso, Constance; Belghazi, Maya; Wong, Anna Hiu Yi; Yuki, Nobuhiro; Fujimura, Harutoshi; Fukutake, Toshio; Iwanami, Hisatake; Kusaka, Hirohumi; Kuwabara, Satoshi; Okuma, Yasuyuki; Ueda, Mitsuharu; Yamamoto, Toru

Cytoalbuminologic dissociation in Asian patients with Guillain-Barré and Miller Fisher syndromes

Journal of the Peripheral Nervous System, v. 20, (1), p. 47-51
Wong, Anna Hiu Yi; Umapathi, Thirugnanam; Nishimoto, Yukihiro; Wang, Yu Zhong; Chan, Yee Cheun; Yuki, Nobuhiro

Guillain-Barre syndrome: Advances in pathogenic understanding and diagnostic improvements

Expert Opinion on Orphan Drugs, v. 3, (7), p. 809-819
Wong, Anna Hiu Yi; Yuki, Nobuhiro

Intravenous immunoglobulin may reduce relapse frequency in neuromyelitis optica

Journal of Neuroimmunology, v. 282, p. 92-96
Viswanathan, Shanthi; Wong, Anna H.Y.; Quek, Amy M.L.; Yuki, Nobuhiro

Miller Fisher Syndrome is a nodo-paranodopathy, but not a myelinopathy

Future Neurology, v. 10, (1), p. 15-24
Yi Wong, Anna Hiu; Yuki, Nobuhiro

Telephone and teleradiology-guided thrombolysis can achieve similar outcome as thrombolysis by neurologist on-site

Journal of Stroke and Cerebrovascular Diseases, v. 24, (6), p. 1223-1228
Fong, Wing Chi; Ismail, Moamina; Lo, Joyce Wai Ting; Li, Jessica Tsz Ching; Wong, Anna Hiu Yi; Ng, Yee Wah; Chan, Phillip Yin Cheung; Chan, Andrew Lung Tat; Chan, Germaine Hiu Fai; Fong, Ka Wing; Cheung, Nelson Yuk Fai; Wong, Gordon Chi Keung; Ho, Hiu Fai; Chan, Shun Tim; Kwok, Vivian Wai Yan; Yuen, Bernard Man Kam; Chan, John Hiu Ming; Li, Patrick Chung Ki

Article 2

Letter corresponding to the article 'Insights into antibody-associated encephalitis' by Dr Merwick et al.

Journal of the Neurological Sciences, v. 341, (1-2), p. 172
Wong, Anna Hiu Yi; Wilder-Smith, Einar; Yuki, Nobuhiro

The value of comparing mortality of Guillain-Barré syndrome across different regions

Journal of the Neurological Sciences, v. 344, (1-2), p. 60-62
Wong, A. H.Y.; Umapathi, T.; Shahrizaila, N.; Chan, Y. C.; Kokubun, N.; Fong, M. K.; Chu, Y. P.; Lau, P. K.; Yuki, N.

2020 2

CD137 / CD137 ligand signalling regulates the immune balance: A potential target for novel immunotherapy of autoimmune diseases

Journal of Autoimmunity, v. 112, article number 102499
Wong, Hiu Yi; Schwarz, Herbert
Article

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand

Frontiers in Immunology, v. 11, article number 571964
Wong, Hiu Yi; Prasad, Ankshita; Gan, Shu Uin; Chua, John Jia En; Schwarz, Herbert
Article

2019 4

Deletion of CD137 ligand exacerbates renal and cutaneous but alleviates cerebral manifestations in Lupus

Frontiers in Immunology, v. 10, (JUN), article number 1411
Mak, Anselm; Dharmadhikari, Bhushan; Kow, Nien Yee; Thamboo, Thomas Paulraj; Tang, Qianqiao; Wong, Lik Wei; Sajikumar, Sreedharan; Wong, Hiu Yi; Schwarz, Herbert
Article

Development of a Bispecific Antibody Targeting CD30 and CD137 on Hodgkin and Reed-Sternberg Cells

Frontiers in Oncology, v. 9, article number 945
Rajendran, Sakthi; Li, Yating; Ngoh, Evelyn; Wong, Hiu Yi; Cheng, Man Si; Wang, Cheng I.; Schwarz, Herbert
Article

Epstein–Barr virus-encoded LMP1 induces ectopic CD137 expression on Hodgkin and Reed–Sternberg cells via the PI3K-AKT-mTOR pathway

Leukemia and Lymphoma, v. 60, (11), p. 2697-2704
Aravinth, Sneha Priya; Rajendran, Sakthi; Li, Yating; Wu, Meihui; Yi Wong, Anna Hiu; Schwarz, Herbert
Article

Induction of CD137 expression by viral genes reduces T cell costimulation

Journal of Cellular Physiology, v. 234, (11), p. 21076-21088
Wu, Meihui; Wong, Hiu Yi; Lin, Jia Le; Moliner, Annalena; Schwarz, Herbert
Article

2018 1

Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome

Muscle and Nerve, v. 57, (2), p. 320-324
Yuki, Nobuhiro; Chan, Amanda C.; Wong, Anna Hiu Yi; Inoue, Takayuki; Yokai, Masafumi; Kurihara, Takashi; Devaux, JérôMe J.; Wilder-Smith, Einar
Article

2016 3

Anti-GQ1b antibody syndrome: Anti-ganglioside complex reactivity determines clinical spectrum

European Journal of Neurology, v. 23, (2), p. 320-326
Fukami, Y.; Wong, A. H.Y.; Funakoshi, K.; Safri, A. Y.; Shahrizaila, N.; Yuki, N.
Article

Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy

Neurology, v. 86, (9), p. 800-807
Devaux, Jérôme J.; Miura, Yumako; Fukami, Yuki; Inoue, Takayuki; Manso, Constance; Belghazi, Maya; Sekiguchi, Kenji; Kokubun, Norito; Ichikawa, Hiroo; Wong, Anna Hiu Yi; Yuki, Nobuhiro
Article

Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy

Journal of Neurology, Neurosurgery and Psychiatry, v. 87, (3), March 2016, p. 275-279
Wong, Hiu Yi; Fukami, Yuki; Sudo, Makoto; Kokubun, Norito; Hamada, Shinsuke; Yuki, Nobuhiro
Article

2015 9

Action mechanism of corticosteroids to aggravate Guillain-Barré syndrome

Scientific Reports, v. 5, article number 13931
Wang, Yu Zhong; Lv, Hui; Shi, Qi Guang; Fan, Xu Tao; Li, Lei; Wong, Anna Hiu Yi; Hao, Yan Lei; Si, Chuan Ping; Li, Cui Lan; Yuki, Nobuhiro
Article

Autoimmune inflammatory neuropathies: Updates in pathogenesis, diagnosis, and treatment

Current Opinion in Neurology, v. 28, (5), p. 468-473
Yi Wong, Anna Hiu; Yuki, Nobuhiro
Article

Chronic inflammatory demyelinating polyneuropathy with membranous nephropathy

Journal of the Peripheral Nervous System, v. 20, (1), p. 63-66
Wong, Anna Hiu Yi; Kokubun, Norito; Fukami, Yuki; Miyaji, Kazuki; Yuki, Nobuhiro
Article

Contactin 1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia

Brain, v. 138, (6), p. 1484-1491
CNTN1-CIDP Study Group; Miura, Yumako; Devaux, Jérôme J.; Fukami, Yuki; Manso, Constance; Belghazi, Maya; Wong, Anna Hiu Yi; Yuki, Nobuhiro; Fujimura, Harutoshi; Fukutake, Toshio; Iwanami, Hisatake; Kusaka, Hirohumi; Kuwabara, Satoshi; Okuma, Yasuyuki; Ueda, Mitsuharu; Yamamoto, Toru
Article

Cytoalbuminologic dissociation in Asian patients with Guillain-Barré and Miller Fisher syndromes

Journal of the Peripheral Nervous System, v. 20, (1), p. 47-51
Wong, Anna Hiu Yi; Umapathi, Thirugnanam; Nishimoto, Yukihiro; Wang, Yu Zhong; Chan, Yee Cheun; Yuki, Nobuhiro
Article

Guillain-Barre syndrome: Advances in pathogenic understanding and diagnostic improvements

Expert Opinion on Orphan Drugs, v. 3, (7), p. 809-819
Wong, Anna Hiu Yi; Yuki, Nobuhiro
Article

Intravenous immunoglobulin may reduce relapse frequency in neuromyelitis optica

Journal of Neuroimmunology, v. 282, p. 92-96
Viswanathan, Shanthi; Wong, Anna H.Y.; Quek, Amy M.L.; Yuki, Nobuhiro
Article

Miller Fisher Syndrome is a nodo-paranodopathy, but not a myelinopathy

Future Neurology, v. 10, (1), p. 15-24
Yi Wong, Anna Hiu; Yuki, Nobuhiro
Article

Telephone and teleradiology-guided thrombolysis can achieve similar outcome as thrombolysis by neurologist on-site

Journal of Stroke and Cerebrovascular Diseases, v. 24, (6), p. 1223-1228
Fong, Wing Chi; Ismail, Moamina; Lo, Joyce Wai Ting; Li, Jessica Tsz Ching; Wong, Anna Hiu Yi; Ng, Yee Wah; Chan, Phillip Yin Cheung; Chan, Andrew Lung Tat; Chan, Germaine Hiu Fai; Fong, Ka Wing; Cheung, Nelson Yuk Fai; Wong, Gordon Chi Keung; Ho, Hiu Fai; Chan, Shun Tim; Kwok, Vivian Wai Yan; Yuen, Bernard Man Kam; Chan, John Hiu Ming; Li, Patrick Chung Ki
Article

2014 2

Letter corresponding to the article 'Insights into antibody-associated encephalitis' by Dr Merwick et al.

Journal of the Neurological Sciences, v. 341, (1-2), p. 172
Wong, Anna Hiu Yi; Wilder-Smith, Einar; Yuki, Nobuhiro
Article

The value of comparing mortality of Guillain-Barré syndrome across different regions

Journal of the Neurological Sciences, v. 344, (1-2), p. 60-62
Wong, A. H.Y.; Umapathi, T.; Shahrizaila, N.; Chan, Y. C.; Kokubun, N.; Fong, M. K.; Chu, Y. P.; Lau, P. K.; Yuki, N.
Article

No Publications

Projects

From January 2024 to December 2026

All Projects 5

No Projects.
Neuropsychiatric symptoms in cognitive progression and Alzheimer’s disease Continuum: biomarker discovery using plasma proteomics

認知進展及阿茲海默癥的神經精神癥狀連續體：運用血漿蛋白組學進行生物標誌物的發掘 Participating

Shanghai Medical Innovation & Development Foundation
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

FU Amy Kit Yu

JIANG Yuanbing

WONG Hiu Yi
2026 -
Deciphering the Factors of Longevity through a Multi-Omics Study in Long-Lived Individuals in Hong Kong

通過多組學研究解密香港長壽個體的長壽因素 Participating

Bright Future Charitable Foundation Limited
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

FU Amy Kit Yu

MOK Kin Ying Boniface

WONG Hiu Yi
2025 -
Explainable AI for Early Prediction of Alzheimer's Disease Using Proteomics and Clinical Data

可解釋人工智能融合蛋白質組學及臨床數據預測阿茲海默癥 Participating

Microsoft Research Asia
Project Team (HKUST)
FU Amy Kit Yu (Lead)

IP Nancy Yuk-Yu

WONG Hiu Yi
2025 - 2026
A Randomized-Controlled Trial of Trazodone on Reducing Plasma sST2 Level and Neurodegeneration Progression in Patients with Amnestic Mild Cognitive Impairment and Obstructive Sleep Apnea

曲唑酮降低輕度認知功能障礙和阻塞性睡眠呼吸暫停患者血漿sST2水平和神經退化的隨機對照試驗 Participating

Innovation and Technology Fund, Morningside Life Science Limited
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

FU Amy Kit Yu

WONG Hiu Yi
2021 - 2024
Development Of A Blood-based Proteome Biomarker Panel For Alzheimer's Disease In Chinese

阿爾茨海默病相關血液蛋白質組學生物標誌物的研發 Participating

Innovation and Technology Fund
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

FU Amy Kit Yu

WONG Hiu Yi
2021 - 2024

Research Interest

Publications

2026 3

2025 4

2023 3

2022 7

2021 1

2020 2

2019 4

2018 1

2016 3

2015 9

2014 2

Article 3

Article 2

Conference paper 2

Article 3

Article 6

Conference paper 1

Article 1

Article 2

Article 4

Article 1

Article 3

Article 9

Article 2

2020 2

2019 4

2018 1

2016 3

2015 9

2014 2

Projects

From January 2024 to December 2026

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