CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly

Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Patients with Rapidly Progressive Dementia

Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

TREMendous microglial effects on neurons

A TREM2 antibody energizes microglia

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent

An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells

APOE and immunity: Research highlights

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

APOE genotypes modify the obesity paradox in dementia

APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology

Association of African Ancestry-Specific APOE Missense Variant R145C with Risk of Alzheimer Disease

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

Pushing the boundaries of brain organoids to study Alzheimer's disease

Sex specific molecular networks and key drivers of Alzheimer’s disease

Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody

Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer’s Disease

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology

A reference human induced pluripotent stem cell line for large-scale collaborative studies

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants

APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology

ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease

Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities

Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice

Clinicopathologic Factors Associated with Reversion to Normal Cognition in Patients with Mild Cognitive Impairment

Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 1): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s diseases

Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (part 2): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s diseases

Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia

Emerging point-of-care autologous cellular therapy using adipose-derived stromal vascular fraction for neurodegenerative diseases

Lipoproteins in the Central Nervous System: From Biology to Pathobiology

LRP1 is a neuronal receptor for α-synuclein uptake and spread

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Performance of plasma phosphorylated tau 181 and 217 in the community

Peripheral apoE4 impairs brain cognition and enhances Alzheimer’s pathology by compromising cerebrovascular function

Solving neurodegeneration: common mechanisms and strategies for new treatments

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation

APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

Comparison of Plasma Phosphorylated Tau Species with Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

Generation and validation of APOE knockout human iPSC-derived cerebral organoids

Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease

Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

Interaction between APOE Genotype and Diabetes in Longevity

Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

Preparation of single cell suspensions enriched in mouse brain vascular cells for single-cell RNA sequencing

Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples

TDP-43 Pathology in Alzheimer’s Disease

Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function

Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis

ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components

APOE2 is associated with longevity independent of Alzheimer’s disease

APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Astrocyte-derived clusterin suppresses amyloid formation in vivo

Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome

Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)

Interaction between APOE genotype and diabetes in cognitive decline

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease

Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3

5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Differential effects of extracellular vesicles of lineage-specific human pluripotent stem cells on the cellular behaviors of isogenic cortical spheroids

Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer’s Disease–Associated Cognitive Deficits

Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

APOE ε2 is associated with increased tau pathology in primary tauopathy

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

Association study between multiple system atrophy and TREM2 p.R47H

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model

Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death

Lipocalin-2 protects the brain during inflammatory conditions

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells

Multiple system atrophy and apolipoprotein E

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β₄₂ in Alzheimer's disease

Intracellular trafficking of TREM2 is regulated by presenilin 1

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Role of LRP1 in the pathogenesis of Alzheimer's disease: Evidence from clinical and preclinical studies

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer’s disease

The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

TREM2/DAP12 complex regulates inflammatory responses in Microglia via the JNK signaling pathway

A rapid and cost-effective method for genotyping apolipoprotein e gene polymorphism

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population

Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Implications of GABAergic neurotransmission in Alzheimer's disease

LRP1 modulates the microglial immune response via regulation of JNK and NF-ΚB signaling pathways

MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Prosaposin is a regulator of progranulin levels and oligomerization

Quercetin stabilizes apolipoprotein e and reduces brain Aβ levels in amyloid model mice

Rapid in vivo measurement of ß-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation

SNX27 deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis

The role of APOE in cerebrovascular dysfunction

TREMs in Alzheimer's disease: Genetic and clinical investigations

TYROBP genetic variants in early-onset Alzheimer's disease

Vascular cell senescence contributes to blood-brain barrier breakdown

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease

Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway

Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Cyclin-dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis

DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response

Demographic and lifestyle characteristics, but not apolipoprotein e genotype, are associated with intelligence among young Chinese college students

Detection and enumeration of circulating tumor cells based on their invasive property

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

Genetics ignite focus on microglial inflammation in Alzheimer's disease

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation

The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation

The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

TREM2 in CNS homeostasis and neurodegenerative disease

Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner

ApoE and Aβ in Alzheimer's disease: Accidental encounters or partners?

ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease

Assessment of peptide chemical modifications on the development of an accurate and precise multiplex selected reaction monitoring assay for Apolipoprotein E isoforms

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Dysregulation of protein trafficking in neurodegeneration

Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionicacid (AMPA) receptor in neurons

M1 muscarinic acetylcholine receptor in Alzheimer's disease

Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells

Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

Soluble apoE/Aβ complex: Mechanism and therapeutic target for APOE4-induced AD risk

Sorting nexin 17 regulates ApoER2 recycling and reelin signaling

Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease

Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls

Trafficking regulation of proteins in Alzheimer's disease

Tyrosine-based Signal Mediates LRP6 Receptor Endocytosis and Desensitization of Wnt/β-Catenin Pathway Signaling

α_2A adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction

A Sorting Nexin 17-Binding Domain Within the LRP1 Cytoplasmic Tail Mediates Receptor Recycling Through the Basolateral Sorting Endosome

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease

Brain regional correlation of amyloid-β with synapses and apolipoprotein e in non-demented individuals: Potential mechanisms underlying regional vulnerability to amyloid-β accumulation

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

Neuronal clearance of amyloid-β by endocytic receptor LRP1

The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/β-Catenin Signaling in Cancer Cells

TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure

Transcriptional regulation and its misregulation in Alzheimer's disease

Apolipoprotein E

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease

Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease

Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β

LRP1-Dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis

Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-β uptake

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6

Dkk1 stabilizes wnt co-receptor LRP6: Implication for Wnt ligand-induced LRP6 down-regulation

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Aβ42 uptake and lysosomal trafficking

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

Mesd is a Universal Inhibitor of Wnt Coreceptors LRP5 and LRP6 and Blocks Wnt/β-Catenin Signaling in Cancer Cells

Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

tPA Activates LDL Receptor-Related Protein 1-Mediated Mitogenic Signaling Involving the p90RSK and GSK3β Pathway

Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: Implication for breast cancer tumorigenesis

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Cooperative folding and ligand-binding properties of LRP6 β-propeller domains

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

Interaction of Reelin with amyloid precursor protein promotes neurite outgrowth

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway

Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9

LRP1 and cerebral amyloid angiopathy

LRP1 shedding in human brain: Roles of ADAM10 and ADAM17

Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death

MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90α autocrine signaling to promote keratinocyte migration

Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways

Receptor-associated protein interacts with amyloid-β peptide and promotes its cellular uptake

Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid β peptides in an in vitro model of the blood-brain barrier cells

tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis

Measurement of receptor endocytosis and recycling

A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155)

A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression

Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

Lipoprotein receptor-related protein-1 mediates amyloid-β-mediated cell death of cerebrovascular cells

Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells

Slow endocytosis of the LDL receptor-related protein 1B: Implications for a novel cytoplasmic tail conformation

The γ/σ1 and α/σ2 hemicomplexes of clathrin adaptors AP-1 and AP-2 Harbor the dileucine recognition site

Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ42 accumulation in amyloid model mice

Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice

LRP in amyloid-β production and metabolism

Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd

Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

Recent advances in basic neurosciences and brain disease: From synapses to behavior

Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein

The generation and function of soluble apoE receptors in the CNS

Zoom in on neurodegeneration

ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its rafts' association

Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease

Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein

LRP and Alzheimer's disease

LRP1B functions as a receptor for Pseudomonas exotoxin

LRP5/6 in Wnt signaling and tumorigenesis

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the β-amyloid precursor protein

Sorting nexin 17 facilitates LRP recycling in the early endosome

Striking differences of LDL receptor-related protein 1B expression in mouse and human

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation

Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway

Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

Is tissue-type plasminogen activator a neuromodulator?

Lipoprotein receptor binding, cellular uptake, and lysosomal delivery of fusions between the Receptor-associated Protein (RAP) and α-L-iduronidase or acid α-glucosidase

LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering β-catenin subcellular distribution

The low density lipoprotein receptor-related protein 1B retains β-amyloid precursor protein at the cell surface and reduces amyloid-β peptide production

Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains

Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration

Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein

Genetics and molecular biology: Phosphorylation of low-density lipoprotein receptor-related protein by platelet-derived growth factor

Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)

Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis

Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration

Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration

Nuclear targeting by the growth factor midkine

Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway

Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants

Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs

Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses

Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by their Distinct Endocytosis Rates

Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein

High Affinity Binding of Receptor-associated Protein to Heparin and Low Density Lipoprotein Receptor-related Protein Requires Similar Basic Amino Acid Sequence Motifs

Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: Implication for receptor-mediated endocytosis

Low-density lipoprotein receptor family: Endocytosis and signal transduction

Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins

The Putative Tumor Suppressor LRP1B, a Novel Member of the Low Density Lipoprotein (LDL) Receptor Family, Exhibits Both Overlapping and Distinct Properties with the LDL Receptor-related Protein

The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family

Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures

Expression of α₂-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells

Lipoproteins in the central nervous system

Role of RAP in the biogenesis of lipoprotein receptors

Role of tissue plasminogen activator receptor LRP in hippocampal long- term potentiation

The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein

Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands

Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide

Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein

The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor

Biological effects of astrocyte-secreted apoE/lipoproteins: Role of LRP

Ca²⁺ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the LDL receptor-related protein

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins

Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein

RAP, a novel type of ER chaperone

Receptor-associated protein: A specialized chaperone and antagonist for members of the LDL receptor gene family

The domain structure of human receptor-associated protein. Protease sensitivity and guanidine HCl denaturation

Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone

ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP)

High density lipoprotein decreases β-amyloid toxicity in cortical cell culture

Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts

The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development

α2-macroglobulin complexes with and mediates the endocytosis of β- amyloid peptide via cell surface low-density lipoprotein receptor-related protein

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein

Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone far LDL receptor-related protein

Binding and endocytosis of 39 kDa protein by mdbk cells

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

Sites Within the 39-kDa Protein Important for Regulating Ligand Binding to the Low-Density Lipoprotein Receptor-Related Protein

The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo

Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo

Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo

Binding analysis of amino-terminal and carboxyl-terminal regions of the 39-kDa protein to the low density lipoprotein receptor-related protein

Cellular receptors for the plasminogen activators

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons

Identification of Domains on the 39‐kDa Protein That Inhibit the Binding of Ligands to the Low Density Lipoprotein Receptor–Related Protein: DOMAINS

LRP and the Receptor‐Mediated Endocytosis of Plasminogen Activators

Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells

Assays for cellular protein binding and ligand internalization

Identification of cell surface binding proteins via covalent cross-linking

Receptor-mediated endocytosis

Receptor-Mediated Endocytosis of Plasminogen Activators

39-kD protein inhibits tissue-type plasminogen activator clearance in vivo

Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures

Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein

Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells

Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells

Identification and partial characterization by chemical cross-linking of a binding protein for tissue-type plasminogen activator (t-PA) on rat hepatoma cells: A plasminogen activator inhibitor type 1-independent t-PA receptor

Low density lipoprotein receptor-related protein/α2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator

A nuclear (guanine-7)-methyltransferase isolated from Ehrlich ascites cells

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model

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Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

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APOE ε2 is associated with increased tau pathology in primary tauopathy

Article

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

Article

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

Article

Association study between multiple system atrophy and TREM2 p.R47H

Article

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Article

Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model

Article

Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death

Article

Lipocalin-2 protects the brain during inflammatory conditions

Article

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

Article

Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells

Article

Multiple system atrophy and apolipoprotein E

Article

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression

Article

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

Article

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease

Article

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Article

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Article

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Article

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

Article

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

Article

Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β₄₂ in Alzheimer's disease

Article

Intracellular trafficking of TREM2 is regulated by presenilin 1

Article

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Article

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

Article

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Article

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Article

Role of LRP1 in the pathogenesis of Alzheimer's disease: Evidence from clinical and preclinical studies

Article

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Article

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Article

Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer’s disease

Article

The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death

Article

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Article

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Article

TREM2/DAP12 complex regulates inflammatory responses in Microglia via the JNK signaling pathway

Article

A rapid and cost-effective method for genotyping apolipoprotein e gene polymorphism

Article

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

Article

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Article

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Article

Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population

Article

Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Article

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology

Article

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Article

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Article

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Article

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Article

Implications of GABAergic neurotransmission in Alzheimer's disease

Article

LRP1 modulates the microglial immune response via regulation of JNK and NF-ΚB signaling pathways

Article

MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy

Article

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease

Article

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Article

Prosaposin is a regulator of progranulin levels and oligomerization

Article

Quercetin stabilizes apolipoprotein e and reduces brain Aβ levels in amyloid model mice

Article

Rapid in vivo measurement of ß-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model

Article

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

Article

SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation

Article

SNX27 deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis

Article

The role of APOE in cerebrovascular dysfunction

Article

TREMs in Alzheimer's disease: Genetic and clinical investigations

Article

TYROBP genetic variants in early-onset Alzheimer's disease

Article

Vascular cell senescence contributes to blood-brain barrier breakdown

Article

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

Article

Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease

Book chapter

Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway

Article

Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Article

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Article

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Article

Cyclin-dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis

Article

DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response

Article

Demographic and lifestyle characteristics, but not apolipoprotein e genotype, are associated with intelligence among young Chinese college students

Article

Detection and enumeration of circulating tumor cells based on their invasive property

Article

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

Article

Genetics ignite focus on microglial inflammation in Alzheimer's disease

Article

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk

Article

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Article

Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain

Article

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

Article

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

Article

The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation

Article

The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation

Article

The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

Article

TREM2 in CNS homeostasis and neurodegenerative disease

Article

Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner

Article

ApoE and Aβ in Alzheimer's disease: Accidental encounters or partners?

Article

ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease

Article

Assessment of peptide chemical modifications on the development of an accurate and precise multiplex selected reaction monitoring assay for Apolipoprotein E isoforms

Article

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Article

Dysregulation of protein trafficking in neurodegeneration

Article

Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionicacid (AMPA) receptor in neurons

Article

M1 muscarinic acetylcholine receptor in Alzheimer's disease

Article

Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells

Article

Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease

Article

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

Article

Soluble apoE/Aβ complex: Mechanism and therapeutic target for APOE4-induced AD risk

Article

Sorting nexin 17 regulates ApoER2 recycling and reelin signaling

Article

Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity

Article

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease

Article

Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls

Article

Trafficking regulation of proteins in Alzheimer's disease

Article

Tyrosine-based Signal Mediates LRP6 Receptor Endocytosis and Desensitization of Wnt/β-Catenin Pathway Signaling

Article

α_2A adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction

Article

A Sorting Nexin 17-Binding Domain Within the LRP1 Cytoplasmic Tail Mediates Receptor Recycling Through the Basolateral Sorting Endosome

Article

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Article

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Article

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease

Article

Brain regional correlation of amyloid-β with synapses and apolipoprotein e in non-demented individuals: Potential mechanisms underlying regional vulnerability to amyloid-β accumulation

Article

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity

Article

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples

Article

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

Article

Neuronal clearance of amyloid-β by endocytic receptor LRP1

Article

The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/β-Catenin Signaling in Cancer Cells

Article

TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure

Article

Transcriptional regulation and its misregulation in Alzheimer's disease

Article

Apolipoprotein E

Book chapter

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

Article

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease

Article

Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease

Article

Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration

Article

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms

Article

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Article

Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β

Article

LRP1-Dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis

Article

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

Article

Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis

Article

Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

Article

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-β uptake

Article

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

Article

Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1

Article

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6

Article

Dkk1 stabilizes wnt co-receptor LRP6: Implication for Wnt ligand-induced LRP6 down-regulation

Article

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Aβ42 uptake and lysosomal trafficking

Article

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

Article

Mesd is a Universal Inhibitor of Wnt Coreceptors LRP5 and LRP6 and Blocks Wnt/β-Catenin Signaling in Cancer Cells

Article

Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4

Article

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration

Article

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

Article

tPA Activates LDL Receptor-Related Protein 1-Mediated Mitogenic Signaling Involving the p90RSK and GSK3β Pathway

Article

Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: Implication for breast cancer tumorigenesis

Article

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

Article

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Article

Cooperative folding and ligand-binding properties of LRP6 β-propeller domains

Article

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

Article

Interaction of Reelin with amyloid precursor protein promotes neurite outgrowth

Article

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

Article

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway

Article

Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9

Article

LRP1 and cerebral amyloid angiopathy

Article

LRP1 shedding in human brain: Roles of ADAM10 and ADAM17

Article

Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death

Article

MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1

Article

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90α autocrine signaling to promote keratinocyte migration

Article

Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways

Article

Receptor-associated protein interacts with amyloid-β peptide and promotes its cellular uptake

Article

Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

Article

Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases

Article

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

Article

Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2

Article

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

Article

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid β peptides in an in vitro model of the blood-brain barrier cells

Article

tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis

Article

Measurement of receptor endocytosis and recycling

Book chapter

A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155)

Article

A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression

Article

Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

Article

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

Article

Lipoprotein receptor-related protein-1 mediates amyloid-β-mediated cell death of cerebrovascular cells

Article

Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells

Article

Slow endocytosis of the LDL receptor-related protein 1B: Implications for a novel cytoplasmic tail conformation

Article

The γ/σ1 and α/σ2 hemicomplexes of clathrin adaptors AP-1 and AP-2 Harbor the dileucine recognition site

Article

Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ42 accumulation in amyloid model mice

Article

Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice

Article

LRP in amyloid-β production and metabolism

Article

Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd

Article

Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

Article

Recent advances in basic neurosciences and brain disease: From synapses to behavior

Article

Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein

Article

The generation and function of soluble apoE receptors in the CNS

Article

Zoom in on neurodegeneration

Article

ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its rafts' association

Article

Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease

Article

Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein

Article

LRP and Alzheimer's disease

Article

LRP1B functions as a receptor for Pseudomonas exotoxin

Article

LRP5/6 in Wnt signaling and tumorigenesis

Article

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

Article

Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the β-amyloid precursor protein

Article

Sorting nexin 17 facilitates LRP recycling in the early endosome

Article

Striking differences of LDL receptor-related protein 1B expression in mouse and human

Article

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

Article

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

Article

Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation

Article

Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway

Article

Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

Article

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

Article

Is tissue-type plasminogen activator a neuromodulator?

Article

Lipoprotein receptor binding, cellular uptake, and lysosomal delivery of fusions between the Receptor-associated Protein (RAP) and α-L-iduronidase or acid α-glucosidase

Article

LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering β-catenin subcellular distribution

Article

The low density lipoprotein receptor-related protein 1B retains β-amyloid precursor protein at the cell surface and reduces amyloid-β peptide production

Article

Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains

Article

Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration

Article

Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein

Article

Genetics and molecular biology: Phosphorylation of low-density lipoprotein receptor-related protein by platelet-derived growth factor

Article

Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)

Article

Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis

Article

Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration

Article

Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration

Article

Nuclear targeting by the growth factor midkine

Article

Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway

Article

Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants

Article

Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs

Article

Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses

Article

Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by their Distinct Endocytosis Rates

Article

Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein

Article

High Affinity Binding of Receptor-associated Protein to Heparin and Low Density Lipoprotein Receptor-related Protein Requires Similar Basic Amino Acid Sequence Motifs

Article

Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: Implication for receptor-mediated endocytosis

Article

Low-density lipoprotein receptor family: Endocytosis and signal transduction

Article

Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins

Article

The Putative Tumor Suppressor LRP1B, a Novel Member of the Low Density Lipoprotein (LDL) Receptor Family, Exhibits Both Overlapping and Distinct Properties with the LDL Receptor-related Protein

Article

The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family

Article

Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures

Article

Expression of α₂-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells

Article

Lipoproteins in the central nervous system

Article

Role of RAP in the biogenesis of lipoprotein receptors

Article

Role of tissue plasminogen activator receptor LRP in hippocampal long- term potentiation

Article

The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein

Article

Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands

Article

Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide

Article

Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein

Article

The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor

Article

Biological effects of astrocyte-secreted apoE/lipoproteins: Role of LRP

Book chapter

Ca²⁺ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the LDL receptor-related protein

Article

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury

Article

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins

Article

Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein

Article

RAP, a novel type of ER chaperone

Article

Receptor-associated protein: A specialized chaperone and antagonist for members of the LDL receptor gene family

Article

The domain structure of human receptor-associated protein. Protease sensitivity and guanidine HCl denaturation

Article

Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone

Article

ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP)

Article

High density lipoprotein decreases β-amyloid toxicity in cortical cell culture

Article

Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts

Article

The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development

Article

α2-macroglobulin complexes with and mediates the endocytosis of β- amyloid peptide via cell surface low-density lipoprotein receptor-related protein

Article

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein

Article

Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein

Article

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone far LDL receptor-related protein

Article

Binding and endocytosis of 39 kDa protein by mdbk cells

Article

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

Article

Sites Within the 39-kDa Protein Important for Regulating Ligand Binding to the Low-Density Lipoprotein Receptor-Related Protein

Article

The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo

Article

Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo

Article

Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo

Article

Binding analysis of amino-terminal and carboxyl-terminal regions of the 39-kDa protein to the low density lipoprotein receptor-related protein

Article

Cellular receptors for the plasminogen activators

Article

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons

Article

Identification of Domains on the 39‐kDa Protein That Inhibit the Binding of Ligands to the Low Density Lipoprotein Receptor–Related Protein: DOMAINS

Article

LRP and the Receptor‐Mediated Endocytosis of Plasminogen Activators

Article

Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells

Article

Assays for cellular protein binding and ligand internalization

Book chapter

Identification of cell surface binding proteins via covalent cross-linking

Book chapter

Receptor-mediated endocytosis

Book chapter

Receptor-Mediated Endocytosis of Plasminogen Activators

Book chapter

39-kD protein inhibits tissue-type plasminogen activator clearance in vivo

Article

Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures

Article

Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein

Article

Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells

Article

Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells

Article

Identification and partial characterization by chemical cross-linking of a binding protein for tissue-type plasminogen activator (t-PA) on rat hepatoma cells: A plasminogen activator inhibitor type 1-independent t-PA receptor

Article

Low density lipoprotein receptor-related protein/α2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator

Article

A nuclear (guanine-7)-methyltransferase isolated from Ehrlich ascites cells

Book chapter