PhD in Biochemistry
Virginia Polytechnic Institute and State University, 1990
Article
Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Patients with Rapidly Progressive Dementia
Article
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease
Article
Article
TREMendous microglial effects on neurons
Article
A TREM2 antibody energizes microglia
Article
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
Article
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent
Article
An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells
Article
APOE and immunity: Research highlights
Article
Article
APOE genotypes modify the obesity paradox in dementia
Article
APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology
Article
Association of African Ancestry-Specific APOE Missense Variant R145C with Risk of Alzheimer Disease
Article
Article
Article
Article
Article
Article
Pushing the boundaries of brain organoids to study Alzheimer's disease
Article
Sex specific molecular networks and key drivers of Alzheimer’s disease
Article
Article
Article
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
Article
Article
Article
A reference human induced pluripotent stem cell line for large-scale collaborative studies
Article
ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias
Article
ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
Article
APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants
Article
Article
ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease
Article
Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities
Article
Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice
Article
Article
Article
Article
Article
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
Article
Article
Lipoproteins in the Central Nervous System: From Biology to Pathobiology
Article
LRP1 is a neuronal receptor for α-synuclein uptake and spread
Article
Article
Performance of plasma phosphorylated tau 181 and 217 in the community
Article
Article
Solving neurodegeneration: common mechanisms and strategies for new treatments
Article
Article
ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation
Article
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Article
Article
Article
Generation and validation of APOE knockout human iPSC-derived cerebral organoids
Article
Article
Article
Interaction between APOE Genotype and Diabetes in Longevity
Article
Article
Article
Article
TDP-43 Pathology in Alzheimer’s Disease
Article
Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function
Article
Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways
Article
Article
Article
APOE2 is associated with longevity independent of Alzheimer’s disease
Article
APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease
Article
Article
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid
Article
Astrocyte-derived clusterin suppresses amyloid formation in vivo
Article
Article
Article
Interaction between APOE genotype and diabetes in cognitive decline
Article
Article
Article
Article
Article
5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway
Article
A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II
Article
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain
Article
APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1
Article
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Article
Article
Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models
Article
Article
Article
Article
AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model
Article
Article
APOE ε2 is associated with increased tau pathology in primary tauopathy
Article
APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology
Article
Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease
Article
Association study between multiple system atrophy and TREM2 p.R47H
Article
Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal
Article
Article
Article
Lipocalin-2 protects the brain during inflammatory conditions
Article
Article
Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells
Article
Multiple system atrophy and apolipoprotein E
Article
Article
Article
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease
Article
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Article
APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes
Article
ApoE4 Accelerates Early Seeding of Amyloid Pathology
Article
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
Article
Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition
Article
Article
Intracellular trafficking of TREM2 is regulated by presenilin 1
Article
Article
Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Article
Article
Article
Article
Soluble TREM2 induces inflammatory responses and enhances microglial survival
Article
Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice
Article
Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer’s disease
Article
The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death
Article
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity
Article
TREM2 promotes microglial survival by activating wnt/β-catenin pathway
Article
TREM2/DAP12 complex regulates inflammatory responses in Microglia via the JNK signaling pathway
Article
A rapid and cost-effective method for genotyping apolipoprotein e gene polymorphism
Article
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology
Article
APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations
Article
Article
Article
Article
Article
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
Article
Article
Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes
Article
Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease
Article
Implications of GABAergic neurotransmission in Alzheimer's disease
Article
LRP1 modulates the microglial immune response via regulation of JNK and NF-ΚB signaling pathways
Article
MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy
Article
Article
Article
Prosaposin is a regulator of progranulin levels and oligomerization
Article
Quercetin stabilizes apolipoprotein e and reduces brain Aβ levels in amyloid model mice
Article
Article
Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1
Article
SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation
Article
SNX27 deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis
Article
The role of APOE in cerebrovascular dysfunction
Article
TREMs in Alzheimer's disease: Genetic and clinical investigations
Article
TYROBP genetic variants in early-onset Alzheimer's disease
Article
Vascular cell senescence contributes to blood-brain barrier breakdown
Article
VPS35 regulates cell surface recycling and signaling of dopamine receptor D1
Article
Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease
Book chapter
Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway
Article
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
Article
Article
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
Article
Article
Article
Article
Detection and enumeration of circulating tumor cells based on their invasive property
Article
Article
Genetics ignite focus on microglial inflammation in Alzheimer's disease
Article
Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk
Article
Article
Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain
Article
Article
Article
The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation
Article
The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation
Article
The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death
Article
TREM2 in CNS homeostasis and neurodegenerative disease
Article
Article
ApoE and Aβ in Alzheimer's disease: Accidental encounters or partners?
Article
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease
Article
Article
Article
Dysregulation of protein trafficking in neurodegeneration
Article
Article
M1 muscarinic acetylcholine receptor in Alzheimer's disease
Article
Article
Article
Article
Soluble apoE/Aβ complex: Mechanism and therapeutic target for APOE4-induced AD risk
Article
Sorting nexin 17 regulates ApoER2 recycling and reelin signaling
Article
Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity
Article
Article
Article
Trafficking regulation of proteins in Alzheimer's disease
Article
Article
α2A adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction
Article
Article
Article
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Article
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease
Article
Article
Ferritin light chain interacts with PEN-2 and affects γ-secretase activity
Article
Article
Article
Neuronal clearance of amyloid-β by endocytic receptor LRP1
Article
Article
TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure
Article
Transcriptional regulation and its misregulation in Alzheimer's disease
Article
Book chapter
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid
Article
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease
Article
Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease
Article
Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration
Article
Article
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Article
Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β
Article
Article
Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations
Article
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis
Article
Article
Article
Article
Article
Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6
Article
Dkk1 stabilizes wnt co-receptor LRP6: Implication for Wnt ligand-induced LRP6 down-regulation
Article
Article
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
Article
Article
Article
Article
Article
Article
Article
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
Article
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Article
Cooperative folding and ligand-binding properties of LRP6 β-propeller domains
Article
Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain
Article
Interaction of Reelin with amyloid precursor protein promotes neurite outgrowth
Article
Article
Article
Article
LRP1 and cerebral amyloid angiopathy
Article
LRP1 shedding in human brain: Roles of ADAM10 and ADAM17
Article
Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death
Article
Article
Article
Article
Receptor-associated protein interacts with amyloid-β peptide and promotes its cellular uptake
Article
Article
Article
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
Article
Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2
Article
LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein
Article
Article
tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis
Article
Measurement of receptor endocytosis and recycling
Book chapter
A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155)
Article
Article
Article
Article
Article
Article
Article
Article
Article
Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice
Article
LRP in amyloid-β production and metabolism
Article
Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd
Article
Article
Recent advances in basic neurosciences and brain disease: From synapses to behavior
Article
Article
The generation and function of soluble apoE receptors in the CNS
Article
Article
Article
Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease
Article
Article
Article
LRP1B functions as a receptor for Pseudomonas exotoxin
Article
LRP5/6 in Wnt signaling and tumorigenesis
Article
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Article
Article
Sorting nexin 17 facilitates LRP recycling in the early endosome
Article
Striking differences of LDL receptor-related protein 1B expression in mouse and human
Article
Article
Article
Article
Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway
Article
Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier
Article
Article
Is tissue-type plasminogen activator a neuromodulator?
Article
Article
Article
Article
Article
Article
Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein
Article
Article
Article
Article
Article
Article
Nuclear targeting by the growth factor midkine
Article
Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway
Article
Article
Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs
Article
Article
Article
Article
Article
Article
Low-density lipoprotein receptor family: Endocytosis and signal transduction
Article
Article
Article
Article
Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures
Article
Article
Lipoproteins in the central nervous system
Article
Role of RAP in the biogenesis of lipoprotein receptors
Article
Role of tissue plasminogen activator receptor LRP in hippocampal long- term potentiation
Article
Article
Article
Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide
Article
Article
Article
Biological effects of astrocyte-secreted apoE/lipoproteins: Role of LRP
Book chapter
Article
ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP)
Article
High density lipoprotein decreases β-amyloid toxicity in cortical cell culture
Article
Article
Article
Article
Article
Article
Article
Binding and endocytosis of 39 kDa protein by mdbk cells
Article
Article
Article
Article
Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo
Article
Article
Article
Cellular receptors for the plasminogen activators
Article
Article
Article
LRP and the Receptor‐Mediated Endocytosis of Plasminogen Activators
Article
Article
Assays for cellular protein binding and ligand internalization
Book chapter
Identification of cell surface binding proteins via covalent cross-linking
Book chapter
Book chapter
Receptor-Mediated Endocytosis of Plasminogen Activators
Book chapter
39-kD protein inhibits tissue-type plasminogen activator clearance in vivo
Article
Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures
Article
Article
Article
Article
Article
Article
A nuclear (guanine-7)-methyltransferase isolated from Ehrlich ascites cells
Book chapter
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent
An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells
APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology
Association of African Ancestry-Specific APOE Missense Variant R145C with Risk of Alzheimer Disease
Pushing the boundaries of brain organoids to study Alzheimer's disease
Sex specific molecular networks and key drivers of Alzheimer’s disease
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
A reference human induced pluripotent stem cell line for large-scale collaborative studies
ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias
ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants
ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease
Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities
Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
Lipoproteins in the Central Nervous System: From Biology to Pathobiology
LRP1 is a neuronal receptor for α-synuclein uptake and spread
Performance of plasma phosphorylated tau 181 and 217 in the community
Solving neurodegeneration: common mechanisms and strategies for new treatments
ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Generation and validation of APOE knockout human iPSC-derived cerebral organoids
Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function
Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways
APOE2 is associated with longevity independent of Alzheimer’s disease
APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid
Astrocyte-derived clusterin suppresses amyloid formation in vivo
Interaction between APOE genotype and diabetes in cognitive decline
5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway
A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain
APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models
AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model
APOE ε2 is associated with increased tau pathology in primary tauopathy
APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology
Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease
Association study between multiple system atrophy and TREM2 p.R47H
Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal
Lipocalin-2 protects the brain during inflammatory conditions
Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition
Intracellular trafficking of TREM2 is regulated by presenilin 1
Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Soluble TREM2 induces inflammatory responses and enhances microglial survival
Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice
Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer’s disease
The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity
TREM2 promotes microglial survival by activating wnt/β-catenin pathway
TREM2/DAP12 complex regulates inflammatory responses in Microglia via the JNK signaling pathway
A rapid and cost-effective method for genotyping apolipoprotein e gene polymorphism
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology
APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes
Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease
Implications of GABAergic neurotransmission in Alzheimer's disease
LRP1 modulates the microglial immune response via regulation of JNK and NF-ΚB signaling pathways
MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy
Prosaposin is a regulator of progranulin levels and oligomerization
Quercetin stabilizes apolipoprotein e and reduces brain Aβ levels in amyloid model mice
Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1
SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation
SNX27 deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis
TREMs in Alzheimer's disease: Genetic and clinical investigations
Vascular cell senescence contributes to blood-brain barrier breakdown
VPS35 regulates cell surface recycling and signaling of dopamine receptor D1
Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
Detection and enumeration of circulating tumor cells based on their invasive property
Genetics ignite focus on microglial inflammation in Alzheimer's disease
Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk
Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain
The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation
The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation
The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death
ApoE and Aβ in Alzheimer's disease: Accidental encounters or partners?
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease
Soluble apoE/Aβ complex: Mechanism and therapeutic target for APOE4-induced AD risk
Sorting nexin 17 regulates ApoER2 recycling and reelin signaling
Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity
α2A adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease
Ferritin light chain interacts with PEN-2 and affects γ-secretase activity
TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure
Transcriptional regulation and its misregulation in Alzheimer's disease
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease
Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease
Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Cooperative folding and ligand-binding properties of LRP6 β-propeller domains
Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain
Interaction of Reelin with amyloid precursor protein promotes neurite outgrowth
Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death
Receptor-associated protein interacts with amyloid-β peptide and promotes its cellular uptake
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2
LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein
tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis
Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice
Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd
Recent advances in basic neurosciences and brain disease: From synapses to behavior
The generation and function of soluble apoE receptors in the CNS
Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Sorting nexin 17 facilitates LRP recycling in the early endosome
Striking differences of LDL receptor-related protein 1B expression in mouse and human
AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model
Article
Article
APOE ε2 is associated with increased tau pathology in primary tauopathy
Article
APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology
Article
Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease
Article
Association study between multiple system atrophy and TREM2 p.R47H
Article
Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal
Article
Article
Article
Lipocalin-2 protects the brain during inflammatory conditions
Article
Article
Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells
Article
Multiple system atrophy and apolipoprotein E
Article
Article
Article
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease
Article
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Article
APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes
Article
ApoE4 Accelerates Early Seeding of Amyloid Pathology
Article
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
Article
Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition
Article
Article
Intracellular trafficking of TREM2 is regulated by presenilin 1
Article
Article
Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Article
Article
Article
Article
Soluble TREM2 induces inflammatory responses and enhances microglial survival
Article
Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice
Article
Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer’s disease
Article
The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death
Article
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity
Article
TREM2 promotes microglial survival by activating wnt/β-catenin pathway
Article
TREM2/DAP12 complex regulates inflammatory responses in Microglia via the JNK signaling pathway
Article
A rapid and cost-effective method for genotyping apolipoprotein e gene polymorphism
Article
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology
Article
APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations
Article
Article
Article
Article
Article
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
Article
Article
Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes
Article
Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease
Article
Implications of GABAergic neurotransmission in Alzheimer's disease
Article
LRP1 modulates the microglial immune response via regulation of JNK and NF-ΚB signaling pathways
Article
MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy
Article
Article
Article
Prosaposin is a regulator of progranulin levels and oligomerization
Article
Quercetin stabilizes apolipoprotein e and reduces brain Aβ levels in amyloid model mice
Article
Article
Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1
Article
SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation
Article
SNX27 deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis
Article
The role of APOE in cerebrovascular dysfunction
Article
TREMs in Alzheimer's disease: Genetic and clinical investigations
Article
TYROBP genetic variants in early-onset Alzheimer's disease
Article
Vascular cell senescence contributes to blood-brain barrier breakdown
Article
VPS35 regulates cell surface recycling and signaling of dopamine receptor D1
Article
Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease
Book chapter
Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway
Article
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
Article
Article
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
Article
Article
Article
Article
Detection and enumeration of circulating tumor cells based on their invasive property
Article
Article
Genetics ignite focus on microglial inflammation in Alzheimer's disease
Article
Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk
Article
Article
Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain
Article
Article
Article
The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation
Article
The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation
Article
The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death
Article
TREM2 in CNS homeostasis and neurodegenerative disease
Article
Article