Faculty Profiles - ZHOU Fred Xiaopu | The Hong Kong University of Science and Technology

Fred Xiaopu ZHOU
周曉璞

PhD in Life Science
The Hong Kong University of Science and Technology, 2018

Research Assistant Professor
Division of Life Science

(852) 3469 2635
xpzhou@ust.hk
Room CYT5008

Google Scholar

xJFfreAAAAAJ

ORCID

0000-0001-5307-5805

Scopus ID

56843847700

Research Interest Publications Projects Teaching Assignment

Research Interest

Genetics
Neuroscience
Neurodegenerative disease
Genomics

Publications

All Years 37 2023 1 2022 7 2021 9 2020 2 2019 5 2018 2 2017 11

2023 1

Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Communications Medicine, v. 3, April 2023, article number 49
Alzheimer’s Disease Neuroimaging Initiative; Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Lv, Ge; Zhang, Huan; Chen, Jiahang; Ye, Tao; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronnie M.N.; Tong, Pui Sze; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Guo, Qihao; Mok, Kin Ying Boniface; Shoai, Maryam; Hardy, John; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

2022 7

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Nature Aging, v. 2, (7), July 2022, p. 616-634
Jiang, Yuanbing; Zhou, Xiaopu; Wong, Hiu Yi; Ouyang, Li; Ip, Fanny Chui Fun; Chau, Man Ni; Lau, Shun Fat; Wu, Wei; Wong, Yew Kit Daniel; Seo, Heukjin; Fu, Wing Yu; Lai, Chit Hang; Chen, Yuewen; Chen, Yu; Tong, Pui Sze; Alzheimer’s Disease Neuroimaging Initiative; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Ying Boniface; Shoai, Maryam; Lehallier, Benoit; Losada, Patricia Moran; O'Brien, Eleanor; Porter, Tenielle; Laws, Simon M.; Hardy, John; Wyss-Coray, Tony; Masters, Colin L.; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Article

Association of SPI1 haplotypes with altered SPI1 gene expression and Alzheimer’s disease risk

Journal of Alzheimer's Disease, v. 86, (4), April 2022, p. 1861-1873
Cao, Han; Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Chen, Yuewen; Lai, Chit Hang; Lo, Ming Nok; Tong, Pui Sze; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Alzheimer’s Disease Neuroimaging Initiative; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice

Nature Biomedical Engineering, v. 6, (2), February 2022, p. 168-180
Duan, Yangyang; Ye, Tao; Qu, Zhe; Chen, Yuewen; Miranda, Abigail Orquiza; Zhou, Xiaopu; Lok, Ka Chun; Chen, Yu; Fu, Kit Yu; Gradinaru, Viviana; Ip, Nancy Yuk-yu
Article

Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong

Journal of Alzheimer's Disease, v. 87, (3), May 2022, p. 1205-1213
Wong, Hiu Yi; Zhong, Huan; Zhou, Xiaopu; Chan, Phillip Y.C.; Kwok, Timothy C.Y.; Mok, Kin; Hardy, John; Ip, Fanny Chui Fun; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology

Advanced Science, 13 June 2022, article number 2201212
Park, Jong-Chan; Barahona-Torres, Natalia; Jang, So-Young; Mok, KinY.; Kim, HaengJun; Han, Sun-Ho; Cho, Kwang-Hyun; Zhou, Xiaopu; Fu, Amy K.Y.; Ip, Nancy Yuk-yu; Seo, Jieun; Choi, Murim; Jeong, Hyobin; Hwang, Daehee; Lee, Dong Young; Byun, Min Soo; Yi, Dahyun; Han, Jong Won; Mook-Jung, Inhee; Hardy, John
Article

An IL1RL1 genetic variant lowers soluble ST2 levels and attenuates the impact of APOE-ε4 in Alzheimer's disease

Jiang, Yuanbing; Zhou, Xiaopu; Wong, Hiu Yi; Ouyang, Li; Ip, Fanny Chui Fun; Chau, Man Ni; Lau, Shun Fat; Wu, Wei; Seo, Heukjin; Fu, Wing Yu; Lai, Chit Hang; Chen, Yuewen; Chen, Yu; Tong, Pui Sze; Alzheimer's Disease Neuroimaging Initiative; Mok, Vincent C.T.; Kwok, Timothy C. Y.; Lehallier, Benoit; Losada, Patricia Morán; O'Brien, Eleanor; Porter, Tenielle; Laws, Simon M.; Wyss-Coray, Tony; Masters, Colin L.; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

SNP2Vec: Scalable Self-Supervised Pre-Training for Genome-Wide Association Study

PROCEEDINGS OF THE 21ST WORKSHOP ON BIOMEDICAL LANGUAGE PROCESSING (BIONLP 2022), 2022, p. 140-154
Cahyawijaya, Samuel; Yu, Tiezheng; Liu, Zihan; Mak, Tiffany T.W.; Zhou, Xiaopu; Ip, Nancy Y.; Fung, Pascale
Conference paper

2021 9

APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

Current Opinion in Neurobiology, v. 69, August 2021, p. 58-67
Zhou, Xiaopu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu
Article

Blood transcriptome analysis for Alzheimer' disease in Hong Kong Chinese population

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, v. 17, (S3), December 2021, article number e056643
Zhong, Huan; Zhou, Xiaopu; Jiang, Yuanbing; Chen, Yu; Lai, N.C.H.; Tong, Pui Sze; Lo, Ronnie M.N.; Kwok, Timonthy C.Y.; Mok, Vincent C.T.; Ip, Fanny Chui Fun; Mok, Kin Ying Boniface; Hardy, John; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese population

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, v. 17, (S3), December 2021, article number e056625
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Zhong, Huan; Chen, Yuewen; Chen, Jiahang; Zhang, Yulin; Ma, Shuangshuang; Lai, Nicole Chit Hang; Lo, Ronnie M.N.; Cheung, Kit; Tong, Pui Sze; Mok, Kin Ying Boniface; Hardy, John; Guo, Qihao; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

GSAP Regulates Lipid Homeostasis and Mitochondrial Function Associated with Alzheimer's Disease

Journal of Experimental Medicine, v. 218, (8), June 2021, article number e20202446
Xu, Peng; Chang, Jerry C.; Zhou, Xiaopu; Wang, Wei; Bamkole, Michael; Wong, Eitan; Bettayeb, Karima; Jiang, Lu-Lin; Huang, Timothy; Luo, Wenjie; Xu, Huaxi; Nairn, Angus C.; Flajolet, Marc; Ip, Nancy Yuk-yu; Li, Yue-Ming; Greengard, Paul
Article

Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging

Alzheimer's and Dementia, 25 May 2021
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Nicole C. H.; Cheung, Kit; Lo, Ronnie M. N.; Tong, Pui Sze; Wong, Bonnie W. Y.; Chan, Andrew L. T.; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

Polygenic Score Models For Alzheimer’s Disease: From Research To Clinical Applications

Frontiers in Neuroscience, v. 15, 29 March 2021, article number 650220
Zhou, Xiaopu; Li, Yolanda Yuen Tung; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu
Article

A high-performance biomarker panel for Alzheimer's disease screening and staging identified by large-scale plasma proteomic profiling

Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Chit Hang; Cheung, Kit; Lo, Ming Nok; Tong, Pui Sze; Wong, Wing Yan; Chan, Andrew L.T.; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Conference paper

A high-performance biomarker panel for Alzheimer's disease screening and staging identified by large-scale plasma proteomic profiling

The Journal of the Alzheimer’s Association, v. 17, (S5), December 2021, article number e056099, Supplement: Biomarkers – Part 2
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Chit Hang; Cheung, Kit; Lo, Ming Nok; Tong, Pui Sze; Wong, Wing Yan; Chan, Andrew L.T.; Mok, Vincent C.T.; Kwok, Timonthy C.Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

Deep learning for polygenic score analysis for Alzheimer’s disease risk prediction in the Chinese population

Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Zhong, Huan; Chen, Yuewen; Chen, Jiahang; Zhang, Yulin; Ma, Shuangshuang; Lai, Chit Hang; Lo, Ming Nok; Cheung, Kit; Tong, Pui Sze; Mok, Kin Ying Boniface; Hardy, John; Guo, Qihao; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Conference paper

2020 2

Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, v. 12, (1), August 2020, article number e12074
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Lai, Nicole C.H.; Li, Yuen Tung; Jiang, Yuanbing; Zhong, Huan; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronie M.N.; Cheung, Kit; Tong, Pui Sze; Ko, Ho; Shoai, Maryam; Mok, Kin Ying Boniface; Hardy, John; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu
Article

Evaluation of genetic risk for Alzheimer’s disease in the Hong Kong Chinese population

Zhou, Xiaopu
Conference paper

2019 5

Changes of Protein Phosphorylation Are Associated with Synaptic Functions during the Early Stage of Alzheimer's Disease

ACS Chemical Neuroscience, v. 10, (9), August 2019, p. 3986-3996
Chen, Yuewen; Xu, Jinying; Zhou, Xiaopu; Liu, Saijuan; Zhang, Yulin; Ma, Shuangshuang; Fu, Kit Yu; Ip, Nancy Yuk-yu; Chen, Yu
Article

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Nature Communications, v. 10, (1), December 2019, article number 3310
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Guo, Qihao; Ip, Chui Fun Fanny; Chen, Yuewen; Mullapudi, Nandita; Giusti-Rodríguez, Paola; Sullivan, Patrick F.; Hardy,John; Fu, Kit Yu; Li, Yun; Ip, Nancy Yuk-yu
Article

Deregulation of IL-33/ST2 signaling in Alzheimer’s disease

Jiang, Yuanbing; Zhou, Xiaopu; Wang, Ye; Lai, N.C.H.; Tong, Pui Sze; Mok, V.C.T.; Kwok, T.C.Y.; Ip, Fanny Chui Fun; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, T.C.Y.; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Mullapudi, Nandita; Hardy, J.; Fu, Kit Yu; Li, Y.; Ip, Nancy Yuk-yu
Conference paper

Whole-genome sequencing for Alzheimer’s disease risk in the Chinese population

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Hardy, J.; Li, Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

2018 2

Identification of Genetic Risk Factors in The Chinese Population Implicates a Role of the Immune System in Alzheimer’s Disease Pathogenesis

Proceedings of the National Academy of Sciences of the United States of America, v. 115, (8), Feb 2018, p. 1697-1706
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Zhao, Qianhua; Chen, Keliang; Chen, Yuewen; Hardy, John; Li, Yun; Fu, Kit Yu; Guo, Qihao; Ip, Nancy Yuk-yu
Article

Identification of Genetic Risk Factors for Alzheimer’s Disease in The Chinese Population

Zhou, Xiaopu
Conference paper

2016 6

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (19), May 2016, p. 2705-2713
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Yat Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, Chi Wai; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu
Article

Fine Mapping of the APOE Locus by Low-pass Whole-genome Sequencing in Chinese Alzheimer’s Disease Patients

Zhou, Xiaopu; Chen, Yu; Zhao, Q.; Chu, M.K.M.; Kwok, C.T.; Mok, K.Y.; Zhang, B.; Fu, Kit Yu; Li, Y.; Guo, Q.; Ip, Nancy Yuk-yu
Conference paper

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline

Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, I.C.W.; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu
Conference paper

IL-33 ameliorates cognitive deficits and amyloid pathology in an Alzheimer’s disease-like mouse model

Fu, Kit Yu; Hung, Kwok Wang; Yuen, M.Y.F.; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Cheung, Tom; Zhang, B; Fu, Wing Yu; Liew, F.Y.; Ip, Nancy Yuk-yu
Conference paper

IL-33 modulates microglial innate immunity in an Alzheimer’s disease-like mouse model

Zhou, Xiaopu; Ip, Nancy Yuk-yu; Cheung, Tom; Liew, F.Y.; Chan, I.C.W.; Mak, D.S.Y.; Yuen, M.Y.F.; Hung, Kwok Wang; Fu, Kit Yu; Fu, Wing Yu
Conference paper

IL-33 Modulates the Inflammatory Response in the Brains of Alzheimer’s disease mouse model

Fu, Wing Yu; Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Liew, F.Y.; Cheung, Tom H.; Ip, Nancy Yuk-yu
Conference paper

2015 5

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling

PLoS ONE, v. 10, (7), July 2015, article number e0133115
Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Chen, Yuewen; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing-Yu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu
Article

Cdk5 regulates activity-dependent gene expression and dendrite development

Journal of Neuroscience, v. 35, (45), November 2015, p. 15127-15134
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk Yu
Article

Axin Regulates Dendritic Spine Development via Cdc42 Signaling

Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Conference paper

Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development

Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

Role of Cdk5 in Activity-Induced Gene Expression and Dendrite Development

Ye, Tao; Liang, Zhuoyi; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

Article 1

Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Communications Medicine, v. 3, April 2023, article number 49
Alzheimer’s Disease Neuroimaging Initiative; Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Lv, Ge; Zhang, Huan; Chen, Jiahang; Ye, Tao; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronnie M.N.; Tong, Pui Sze; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Guo, Qihao; Mok, Kin Ying Boniface; Shoai, Maryam; Hardy, John; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-yu

Article 5

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Nature Aging, v. 2, (7), July 2022, p. 616-634
Jiang, Yuanbing; Zhou, Xiaopu; Wong, Hiu Yi; Ouyang, Li; Ip, Fanny Chui Fun; Chau, Man Ni; Lau, Shun Fat; Wu, Wei; Wong, Yew Kit Daniel; Seo, Heukjin; Fu, Wing Yu; Lai, Chit Hang; Chen, Yuewen; Chen, Yu; Tong, Pui Sze; Alzheimer’s Disease Neuroimaging Initiative; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Ying Boniface; Shoai, Maryam; Lehallier, Benoit; Losada, Patricia Moran; O'Brien, Eleanor; Porter, Tenielle; Laws, Simon M.; Hardy, John; Wyss-Coray, Tony; Masters, Colin L.; Fu, Kit Yu; Ip, Nancy Yuk-Yu

Association of SPI1 haplotypes with altered SPI1 gene expression and Alzheimer’s disease risk

Journal of Alzheimer's Disease, v. 86, (4), April 2022, p. 1861-1873
Cao, Han; Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Chen, Yuewen; Lai, Chit Hang; Lo, Ming Nok; Tong, Pui Sze; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Alzheimer’s Disease Neuroimaging Initiative; Fu, Kit Yu; Ip, Nancy Yuk-yu

Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice

Nature Biomedical Engineering, v. 6, (2), February 2022, p. 168-180
Duan, Yangyang; Ye, Tao; Qu, Zhe; Chen, Yuewen; Miranda, Abigail Orquiza; Zhou, Xiaopu; Lok, Ka Chun; Chen, Yu; Fu, Kit Yu; Gradinaru, Viviana; Ip, Nancy Yuk-yu

Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong

Journal of Alzheimer's Disease, v. 87, (3), May 2022, p. 1205-1213
Wong, Hiu Yi; Zhong, Huan; Zhou, Xiaopu; Chan, Phillip Y.C.; Kwok, Timothy C.Y.; Mok, Kin; Hardy, John; Ip, Fanny Chui Fun; Fu, Kit Yu; Ip, Nancy Yuk-yu

Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology

Advanced Science, 13 June 2022, article number 2201212
Park, Jong-Chan; Barahona-Torres, Natalia; Jang, So-Young; Mok, KinY.; Kim, HaengJun; Han, Sun-Ho; Cho, Kwang-Hyun; Zhou, Xiaopu; Fu, Amy K.Y.; Ip, Nancy Yuk-yu; Seo, Jieun; Choi, Murim; Jeong, Hyobin; Hwang, Daehee; Lee, Dong Young; Byun, Min Soo; Yi, Dahyun; Han, Jong Won; Mook-Jung, Inhee; Hardy, John

Conference paper 2

An IL1RL1 genetic variant lowers soluble ST2 levels and attenuates the impact of APOE-ε4 in Alzheimer's disease

Jiang, Yuanbing; Zhou, Xiaopu; Wong, Hiu Yi; Ouyang, Li; Ip, Fanny Chui Fun; Chau, Man Ni; Lau, Shun Fat; Wu, Wei; Seo, Heukjin; Fu, Wing Yu; Lai, Chit Hang; Chen, Yuewen; Chen, Yu; Tong, Pui Sze; Alzheimer's Disease Neuroimaging Initiative; Mok, Vincent C.T.; Kwok, Timothy C. Y.; Lehallier, Benoit; Losada, Patricia Morán; O'Brien, Eleanor; Porter, Tenielle; Laws, Simon M.; Wyss-Coray, Tony; Masters, Colin L.; Fu, Kit Yu; Ip, Nancy Yuk-yu

SNP2Vec: Scalable Self-Supervised Pre-Training for Genome-Wide Association Study

PROCEEDINGS OF THE 21ST WORKSHOP ON BIOMEDICAL LANGUAGE PROCESSING (BIONLP 2022), 2022, p. 140-154
Cahyawijaya, Samuel; Yu, Tiezheng; Liu, Zihan; Mak, Tiffany T.W.; Zhou, Xiaopu; Ip, Nancy Y.; Fung, Pascale

Article 6

APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

Current Opinion in Neurobiology, v. 69, August 2021, p. 58-67
Zhou, Xiaopu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu

Blood transcriptome analysis for Alzheimer' disease in Hong Kong Chinese population

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, v. 17, (S3), December 2021, article number e056643
Zhong, Huan; Zhou, Xiaopu; Jiang, Yuanbing; Chen, Yu; Lai, N.C.H.; Tong, Pui Sze; Lo, Ronnie M.N.; Kwok, Timonthy C.Y.; Mok, Vincent C.T.; Ip, Fanny Chui Fun; Mok, Kin Ying Boniface; Hardy, John; Fu, Kit Yu; Ip, Nancy Yuk-yu

Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese population

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, v. 17, (S3), December 2021, article number e056625
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Zhong, Huan; Chen, Yuewen; Chen, Jiahang; Zhang, Yulin; Ma, Shuangshuang; Lai, Nicole Chit Hang; Lo, Ronnie M.N.; Cheung, Kit; Tong, Pui Sze; Mok, Kin Ying Boniface; Hardy, John; Guo, Qihao; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-yu

GSAP Regulates Lipid Homeostasis and Mitochondrial Function Associated with Alzheimer's Disease

Journal of Experimental Medicine, v. 218, (8), June 2021, article number e20202446
Xu, Peng; Chang, Jerry C.; Zhou, Xiaopu; Wang, Wei; Bamkole, Michael; Wong, Eitan; Bettayeb, Karima; Jiang, Lu-Lin; Huang, Timothy; Luo, Wenjie; Xu, Huaxi; Nairn, Angus C.; Flajolet, Marc; Ip, Nancy Yuk-yu; Li, Yue-Ming; Greengard, Paul

Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging

Alzheimer's and Dementia, 25 May 2021
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Nicole C. H.; Cheung, Kit; Lo, Ronnie M. N.; Tong, Pui Sze; Wong, Bonnie W. Y.; Chan, Andrew L. T.; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu

Polygenic Score Models For Alzheimer’s Disease: From Research To Clinical Applications

Frontiers in Neuroscience, v. 15, 29 March 2021, article number 650220
Zhou, Xiaopu; Li, Yolanda Yuen Tung; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu

Conference paper 3

A high-performance biomarker panel for Alzheimer's disease screening and staging identified by large-scale plasma proteomic profiling

Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Chit Hang; Cheung, Kit; Lo, Ming Nok; Tong, Pui Sze; Wong, Wing Yan; Chan, Andrew L.T.; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-Yu

A high-performance biomarker panel for Alzheimer's disease screening and staging identified by large-scale plasma proteomic profiling

The Journal of the Alzheimer’s Association, v. 17, (S5), December 2021, article number e056099, Supplement: Biomarkers – Part 2
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Chit Hang; Cheung, Kit; Lo, Ming Nok; Tong, Pui Sze; Wong, Wing Yan; Chan, Andrew L.T.; Mok, Vincent C.T.; Kwok, Timonthy C.Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu

Deep learning for polygenic score analysis for Alzheimer’s disease risk prediction in the Chinese population

Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Zhong, Huan; Chen, Yuewen; Chen, Jiahang; Zhang, Yulin; Ma, Shuangshuang; Lai, Chit Hang; Lo, Ming Nok; Cheung, Kit; Tong, Pui Sze; Mok, Kin Ying Boniface; Hardy, John; Guo, Qihao; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu

Article 1

Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, v. 12, (1), August 2020, article number e12074
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Lai, Nicole C.H.; Li, Yuen Tung; Jiang, Yuanbing; Zhong, Huan; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronie M.N.; Cheung, Kit; Tong, Pui Sze; Ko, Ho; Shoai, Maryam; Mok, Kin Ying Boniface; Hardy, John; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu

Conference paper 1

Evaluation of genetic risk for Alzheimer’s disease in the Hong Kong Chinese population

Zhou, Xiaopu

Article 2

Changes of Protein Phosphorylation Are Associated with Synaptic Functions during the Early Stage of Alzheimer's Disease

ACS Chemical Neuroscience, v. 10, (9), August 2019, p. 3986-3996
Chen, Yuewen; Xu, Jinying; Zhou, Xiaopu; Liu, Saijuan; Zhang, Yulin; Ma, Shuangshuang; Fu, Kit Yu; Ip, Nancy Yuk-yu; Chen, Yu

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Nature Communications, v. 10, (1), December 2019, article number 3310
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Guo, Qihao; Ip, Chui Fun Fanny; Chen, Yuewen; Mullapudi, Nandita; Giusti-Rodríguez, Paola; Sullivan, Patrick F.; Hardy,John; Fu, Kit Yu; Li, Yun; Ip, Nancy Yuk-yu

Conference paper 3

Deregulation of IL-33/ST2 signaling in Alzheimer’s disease

Jiang, Yuanbing; Zhou, Xiaopu; Wang, Ye; Lai, N.C.H.; Tong, Pui Sze; Mok, V.C.T.; Kwok, T.C.Y.; Ip, Fanny Chui Fun; Fu, Kit Yu; Ip, Nancy Yuk-yu

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, T.C.Y.; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Mullapudi, Nandita; Hardy, J.; Fu, Kit Yu; Li, Y.; Ip, Nancy Yuk-yu

Whole-genome sequencing for Alzheimer’s disease risk in the Chinese population

Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Hardy, J.; Li, Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu

Article 1

Identification of Genetic Risk Factors in The Chinese Population Implicates a Role of the Immune System in Alzheimer’s Disease Pathogenesis

Proceedings of the National Academy of Sciences of the United States of America, v. 115, (8), Feb 2018, p. 1697-1706
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Zhao, Qianhua; Chen, Keliang; Chen, Yuewen; Hardy, John; Li, Yun; Fu, Kit Yu; Guo, Qihao; Ip, Nancy Yuk-yu

Conference paper 1

Identification of Genetic Risk Factors for Alzheimer’s Disease in The Chinese Population

Zhou, Xiaopu

Article 1

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (19), May 2016, p. 2705-2713
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Yat Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, Chi Wai; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu

Conference paper 5

Fine Mapping of the APOE Locus by Low-pass Whole-genome Sequencing in Chinese Alzheimer’s Disease Patients

Zhou, Xiaopu; Chen, Yu; Zhao, Q.; Chu, M.K.M.; Kwok, C.T.; Mok, K.Y.; Zhang, B.; Fu, Kit Yu; Li, Y.; Guo, Q.; Ip, Nancy Yuk-yu

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline

Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, I.C.W.; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu

IL-33 ameliorates cognitive deficits and amyloid pathology in an Alzheimer’s disease-like mouse model

Fu, Kit Yu; Hung, Kwok Wang; Yuen, M.Y.F.; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Cheung, Tom; Zhang, B; Fu, Wing Yu; Liew, F.Y.; Ip, Nancy Yuk-yu

IL-33 modulates microglial innate immunity in an Alzheimer’s disease-like mouse model

Zhou, Xiaopu; Ip, Nancy Yuk-yu; Cheung, Tom; Liew, F.Y.; Chan, I.C.W.; Mak, D.S.Y.; Yuen, M.Y.F.; Hung, Kwok Wang; Fu, Kit Yu; Fu, Wing Yu

IL-33 Modulates the Inflammatory Response in the Brains of Alzheimer’s disease mouse model

Fu, Wing Yu; Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Liew, F.Y.; Cheung, Tom H.; Ip, Nancy Yuk-yu

Article 2

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling

PLoS ONE, v. 10, (7), July 2015, article number e0133115
Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Chen, Yuewen; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing-Yu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu

Cdk5 regulates activity-dependent gene expression and dendrite development

Journal of Neuroscience, v. 35, (45), November 2015, p. 15127-15134
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk Yu

Conference paper 3

Axin Regulates Dendritic Spine Development via Cdc42 Signaling

Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu

Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development

Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu

Role of Cdk5 in Activity-Induced Gene Expression and Dendrite Development

Ye, Tao; Liang, Zhuoyi; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu

2016 6

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline

Proceedings of the National Academy of Sciences of the United States of America, v. 113, (19), May 2016, p. 2705-2713
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Yat Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, Chi Wai; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu
Article

Fine Mapping of the APOE Locus by Low-pass Whole-genome Sequencing in Chinese Alzheimer’s Disease Patients

Zhou, Xiaopu; Chen, Yu; Zhao, Q.; Chu, M.K.M.; Kwok, C.T.; Mok, K.Y.; Zhang, B.; Fu, Kit Yu; Li, Y.; Guo, Q.; Ip, Nancy Yuk-yu
Conference paper

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline

Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, I.C.W.; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu
Conference paper

IL-33 ameliorates cognitive deficits and amyloid pathology in an Alzheimer’s disease-like mouse model

Fu, Kit Yu; Hung, Kwok Wang; Yuen, M.Y.F.; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Cheung, Tom; Zhang, B; Fu, Wing Yu; Liew, F.Y.; Ip, Nancy Yuk-yu
Conference paper

IL-33 modulates microglial innate immunity in an Alzheimer’s disease-like mouse model

Zhou, Xiaopu; Ip, Nancy Yuk-yu; Cheung, Tom; Liew, F.Y.; Chan, I.C.W.; Mak, D.S.Y.; Yuen, M.Y.F.; Hung, Kwok Wang; Fu, Kit Yu; Fu, Wing Yu
Conference paper

IL-33 Modulates the Inflammatory Response in the Brains of Alzheimer’s disease mouse model

Fu, Wing Yu; Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Liew, F.Y.; Cheung, Tom H.; Ip, Nancy Yuk-yu
Conference paper

2015 5

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling

PLoS ONE, v. 10, (7), July 2015, article number e0133115
Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Chen, Yuewen; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing-Yu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu
Article

Cdk5 regulates activity-dependent gene expression and dendrite development

Journal of Neuroscience, v. 35, (45), November 2015, p. 15127-15134
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk Yu
Article

Axin Regulates Dendritic Spine Development via Cdc42 Signaling

Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing Yu; Fu, Kit Yu; Ip, Nancy Yuk-Yu
Conference paper

Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development

Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

Role of Cdk5 in Activity-Induced Gene Expression and Dendrite Development

Ye, Tao; Liang, Zhuoyi; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu
Conference paper

Teaching Assignment

2022-23 Spring 1 2022-23 Winter 0 2022-23 Fall 0 2021-22 Summer 0 2021-22 Spring 0 2021-22 Winter 0

LIFS5260

Biochemical and Molecular Basis of Diseases

No Teaching Assignments

Projects

From January 2021 to December 2023

All Projects 10 Leading Projects 2 Participating Projects 8

Investigating the genetic factors and associated mechanisms that modulate the risk effects of APOE-ε4 in Alzheimer’s disease

探究影響APOE-ε4在阿爾茨海默癥中風險作用的遺傳因素和相關機制 Leading

RGC - General Research Fund
Project Team (HKUST)
ZHOU Fred Xiaopu (Lead)

FU Amy Kit Yu

IP Nancy Yuk-Yu
2022 -
A Deep Learning Algorithm for Aging Prediction Based on Plasma Protein

一種基於血漿蛋白的衰老預測深度學習算法 Participating

Microsoft Research Asia
Project Team (HKUST)
CHEN Lei (Lead)

ZHOU Fred Xiaopu
2022 -
A Randomized-Controlled Trial of Trazodone on Reducing Plasma sST2 Level and Neurodegeneration Progression in Patients with Amnestic Mild Cognitive Impairment and Obstructive Sleep Apnea

曲唑酮降低輕度認知功能障礙和阻塞性睡眠呼吸暫停患者血漿sST2水平和神經退化的隨機對照試驗 Participating

Innovation and Technology Fund, Morningside Life Science Limited
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

FU Amy Kit Yu

WONG Hiu Yi

ZHOU Fred Xiaopu
2021 -
Development Of A Blood-based Proteome Biomarker Panel For Alzheimer's Disease In Chinese

阿爾茨海默病相關血液蛋白質組學生物標誌物的研發 Participating

Innovation and Technology Fund
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

FU Amy Kit Yu

WONG Hiu Yi

ZHOU Fred Xiaopu
2021 -
Fox Genetic Diversity in PD Program: Genomewide Association Study in Parkinson’s Disease among East Asian Participating

Michael J Fox Foundation for Parkinson's Research
Project Team (HKUST)
FU Amy Kit Yu

IP Nancy Yuk-Yu

ZHOU Fred Xiaopu
2021 -
Regulation of the pathogenesis of Alzheimer's disease by SORL1 genetic variants

SORL1基因突變調控阿爾茨海默癥病變發生的分子機制 Leading

Shenzhen Science and Technology Innovation Strategy Research and Technology Transfer Promotion Center
Project Team (HKUST)
ZHOU Fred Xiaopu (Lead)
2021 -
Study on the biomarkers for neurodegenerative diseases

神經退行性疾病的生物標志物研究 Participating

Guangdong Natural Science Foundation
Project Team (HKUST)
FU Amy Kit Yu

IP Nancy Yuk-Yu

ZHOU Fred Xiaopu
2020 -
Modelling and application of risk assessment based on molecular biomakers

基于生物標志物的風險評估模型建立和應用 Participating

Shenzhen Science and Technology Innovation Committee
Project Team (HKUST)
CHEUNG Tom (Lead)

ZHOU Fred Xiaopu
2020 - 2022
Multi-dimensional analysis of biomarkers for Alzheimer's disease in the Chinese population

中國人群阿爾茨海默癥多維度生物標志物綜合研究 Participating

Ministry of Science and Technology of the People's Republic of China
Project Team (HKUST)
CHEUNG Tom

IP Nancy Yuk-Yu

ZHOU Fred Xiaopu
2019 - 2022
The Research on diagnosis and treatment of Alzheimer's disease

阿爾茨海默癥的診治方法研究 Participating

Department of Science and Technology of Guangdong Province
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

CHEUNG Tom

FU Amy Kit Yu

LIU Kai

WONG Yung Hou

WU Zhenguo

ZHOU Fred Xiaopu
2018 - 2022

Research Interest

Publications

2023 1

2022 7

2021 9

2020 2

2019 5

2018 2

2016 6

2015 5

Article 1

Article 5

Conference paper 2

Article 6

Conference paper 3

Article 1

Conference paper 1

Article 2

Conference paper 3

Article 1

Conference paper 1

Article 1

Conference paper 5

Article 2

Conference paper 3

2016 6

2015 5

Teaching Assignment

Projects

From January 2021 to December 2023

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