Faculty Profiles - SUN Fei | The Hong Kong University of Science and Technology

2024 2

Identifications of novel host cell factors that interact with the receptor binding domain of the SARS-CoV-2 spike protein

Journal of biological chemistry, v. 300, (6), June 2024, article number 107390
Tang, Xiao; Liu, Yang; Wang, Jinhui; Long, Teng; Mok, Bobo Wing Yee; Huang, Yan; Peng, Ziqing; Jia, Qinyu; Liu, Chengxi; So, Pui-Kin; Tse, Sirius Pui-Kam; Ng, Cheuk Hei; Liu, Shiyi; Sun, Fei; Tang, Shaojun; Yao, Zhong-Ping; Chen, Honglin; Guo, Yusong
Article

Nonionic Water-Soluble Oligo(ethylene glycol)-Modified Polypeptides with a β-Sheet Conformation

Biomacromolecules, v. 25, (8), July 2024, p. 5343-5351
Jing, Xiaodong; Zhu, Zhen; Wang, Shuo; Xin, Jiaqi; Zhou, Haisen; Wang, Letian; Tong, Huimin; Cui, Chenhui; Zhang, Yanfeng; Sun, Fei; Yang, Lijiang; Gao, Yiqin; Lu, Hua
Article

2023 2

Designed Multifunctional Spider Silk Enabled by Genetically Encoded Click Chemistry

Advanced Functional Materials, June 2023, article number 2304143
Jiang, Bojing; Tan, Sin Yen; Fang, Shiyu; Feng, Xiaohan; Park, Byung Min; Fok, Hong Kiu Francis; Yang, Zhongguang; Wang, Ri; Kou, Songzi; Wu, Angela Ruohao; Sun, Fei
Article

SpyStapler-mediated assembly of nanoparticle vaccines

Nano Research, v. 16, (2), February 2023, p. 2821-2828
Kou, Songzi; Chen, Weitao; Sun, Chenbo; Sun, Fei
Article

2022 8

B₁₂-dependent photoreceptor protein as an emerging tool for materials synthetic biology

Smart Materials in Medicine, v. 3, January 2022, p. 297-303
Fok, Hong Kiu Francis; Sun, Fei
Article

B₁₂-induced reassembly of split photoreceptor protein enables photoresponsive hydrogels with tunable mechanics

Science Advances, v. 8, (13), April 2022, article number eabm5482
Yang, Zhongguang; Fok, Hong Kiu Francis; Luo, Jiren; Yang, Yang; Wang, Ri; Zhuang, Xinyu; Sun, Fei
Article

Controlling synthetic membraneless organelles by a red-light-dependent singlet oxygen-generating protein

Nature Communications, v. 13, (1), June 2022, article number 3197
Li, Manjia; Park, Byung Min; Dai, Xin; Xu, Yingjie; Huang, Jinqing; Sun, Fei
Article

Directed assembly of genetically engineered eukaryotic cells into living functional materials via ultrahigh-affinity protein interactions

Science Advances, v. 8, (44), 4 November 2022, article number eade0073
Yi, Qikun; Dai, Xin; Park, Byung Min; Gu, Junhao; Luo, Jiren; Wang, Ri; Yu, Cong; Kou, Songzi; Huang, Jinqing; Lakerveld, Richard; Sun, Fei
Article

From 4-arm star proteins to diverse stimuli-responsive molecular networks enabled by orthogonal genetically encoded click chemistries

Polymer Chemistry, v. 13, (16), April 2022, p. 2331-2339
Fok, Hong Kiu Francis; Yang, Zhongguang; Jiang, Bojing; Sun, Fei
Article

Genetically engineered materials: Proteins and beyond

Science China Chemistry, v. 65, (3), March 2022, p. 486-496
Wei, Jingjing; Xu, Lianjie; Wu, Wen Hao; Sun, Fei; Zhang, Wen Bin
Article

PETase gets hot

Chem Catalysis, v. 2, (10), October 2022, p. 2437-2439
Alvina, Maria Joscelind; Wei, Jingjing; Sun, Fei
Article

可基因编码点击化学在材料合成生物学中的应用

合成生物学=Synthetic Biology Journal, v. 3, March 2022, p. 1-19
易琪昆; 孙晨博; 杨中光; 王日; 寇松姿; 李朝霞; 孙飞
Article

2021 6

Cu₃Pd_xN nanocrystals for efficient CO₂ electrochemical reduction to methane

Electrochimica Acta, v. 371, March 2021, article number 137793
Li, Tiehuai; Wang, Jing; Zhu, Shangqian; Delmo, Ernest Pahuyo; Sun, Fei; Zhang, Lili; Gu, Meng; Shao, Minhua
Article

Harnessing Proteins For Engineered Living Materials

Current Opinion in Solid State and Materials Science, v. 25, (1), February 2021, article number 100896
Xu, Lianjie; Wang, Xinyu; Sun, Fei; Cao, Yi; Zhong, Chao; Zhang, Wen Bin
Article

Reaction: Engineer Biology for Uranium

Chem, v. 7, (2), February 2021, p. 274-275
Sun, Fei; He, Chuan
Article

Time-dependent response of bio-polymer networks regulated by catch and slip bond-like kinetics of cross-linkers

Journal of the Mechanics and Physics of Solids, v. 147, February 2021, article number 104267
Wei, X.; Fang, C.; Gong, B.; Shao, X.; Sun, Fei; Qian, J.; Lin, Y.
Article

Self-Assembly and Genetically Engineered Hydrogels

Tunable Hydrogels: Smart Materials for Biomedical Applications / Edited by Antonina Lavrentieva, Iliyana Pepelanova, Dror Seliktar. Switzerland : Springer Nature, 2021, p. 169-196, Book Series: Advances in Biochemical Engineering/Biotechnology, v. 178
Yang, Zhongguang; Sun, Fei
Book chapter

The Spy that links: Creation of nonlinear protein architectures and materials using SpyTag/SpyCatcher chemistry

Linkers in Biomacromolecules / Edited by Maarten Merkx. Cambridge, Massachusetts : Academic Press, 2021, p. 283-301, Ch. 11. Book Series: Methods in Enzymology, v. 647
Wang, Ri; Sun, Fei
Book chapter

2020 8

Calcium-responsive hydrogels enabled by inducible protein-protein interactions

Polymer Chemistry, v. 11, (31), 21 August 2020, p. 4973-4977
Luo, Jiren; Sun, Fei
Article

Dynamically Tunable, Macroscopic Molecular Networks Enabled by Cellular Synthesis of 4-Arm Star-like Proteins

Matter, v. 2, (1), January 2020, p. 233-249
Yang, Zhongguang; Yang, Yang; Wang, Mo; Wang, Tingting; Fok, Hong Kiu Francis; Jiang, Bojing; Xiao, Wendi; Kou, Songzi; Guo, Yusong; Yan, Yan; Deng, Xin; Zhang, Wen-Bin; Sun, Fei
Article

Editorial: Synthesis of Novel Hydrogels With Unique Mechanical Properties

Frontiers in Chemistry, v. 8, October 2020, article number 595392
Li, Ying; Blank, Kerstin G.; Sun, Fei; Cao, Yi
Article

Genetically Encoded Click Chemistry†

Chinese Journal of Chemistry, May 2020
Sun, Fei; Zhang, Wenbin
Article

Give Life to a Glue

Matter, v. 3, (6), December 2020, p. 1820-1822
Wang, Ri; Jiang, Bojing; Sun, Fei
Article

Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly

Science Advances, v. 6, (41), 7 October 2020, article number eabc4824
Jiang, Bojing; Liu, Xiaotian; Yang, Chao; Yang, Zhongguang; Luo, Jiren; Kou, Songzi; Liu, Kai; Sun, Fei
Article

Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly

Molecular Systems Design & Engineering, v. 5, (1), January 2020, p. 117-124
Cao, Yujie; Wei, Xi; Lin, Yuan; Sun, Fei
Article

Photoresponsive hydrogels

Photochemistry / Editors: Angelo Albini, Stefano Protti. United Kingdom : Royal Society of Chemistry, 2020, p. 379-403, v. 47
Wang, Ri; Sun, Fei
Book chapter

2019 2

Cobalt-Cross-Linked, Redox-Responsive Spy Network Protein Hydrogels

ACS Macro Letters, v. 8, (7), June 2019, p. 773-778
Kou, Songzi; Yang, Xin; Yang, Zhongguang; Liu, Xiaotian; Wegner, Seraphine V.; Sun, Fei
Article

Enzymatic Assembly of Adhesive Molecular Networks With Sequence-dependent Mechanical Properties Inspired by Mussel Foot Proteins

Polymer Chemistry, v. 10, (7), Febuary 2019, p. 823-826
Park, Byung Min; Luo, Jiran; Sun, Fei
Article

2018 8

A Versatile and Robust Approach to Stimuli-Responsive Protein Multilayers with Biologically Enabled Unique Functions

Biomacromolecules, v. 19, (3), March 2018, p. 1065-1073
Zhang, X.-J.; Wang, X.-W.; Da, X.-D.; Shi, Y.; Liu, C.; Sun, Fei; Yang, S.; Zhang, W.-B.
Article

An Intrinsically Disordered Peptide-Peptide Stapler for Highly Efficient Protein Ligation Both in Vivo and in Vitro

Journal of the American Chemical Society, v. 140, (50), December 2018, p. 17474-17483
Wu, Xia-Ling; Liu, Yajie; Liu, Dong; Sun, Fei; Zhang, Wen-Bin
Article

B₁₂-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms

ACS Macro Letters, v. 7, (5), April 2018, p. 514-518
Wei, jingjing; Wu, wenhao; Wang, Ri; Yang, Zhongguang; Sun, Fei; Zhang, wenbin
Article

Genetically Programming Stress-Relaxation Behavior in Entirely Protein-Based Molecular Networks

ACS Macro Letters, v. 7, (12), December 2018, p. 1468-1474
Yang, Zhongguang; Kou, Songzi; Wei, Xi; Zhang, Fengjie; Li, Fei; Wang, Xiao-Wei; Lin, Yuan; Wan, Chao; Zhang, Wen-Bin; Sun, Fei
Article

Modular Functionalization of Crystalline Graphene by Recombinant Proteins: A Nanoplatform for Probing Biomolecules

Nanoscale, v. 10, (47), 21 December 2018, p. 22572-22582
Tyagi, Abhishek; Liu, Xiaotian; Abidi, Irfan Haider; Gao, Zhaoli; Park, Byung Min; Zeng, Xiangze; Ou, Xuewu; Cagang, Aldrine Abenoja; Zhuang, Minghao; Hossain, Md Delowar; Zhang, Kai; Weng, Lutao; Sun, Fei; Luo, Zhengtang
Article

Reversible hydrogels with tunable mechanical properties for optically controlling cell migration

Nano Research, v. 11, (10), Ocotber 2018, p. 5556-5565
Wu, xin; Huang, wenmao; Wu, wenhao; Xue, bin; Xiang, dongfang; Li, Ying; Qin, Meng; Sun, Fei; Wang, wei; Zhang, wenbin; Cao, yi
Article

Synthesis of Entirely Protein-Based Hydrogels by Enzymatic Oxidation Enabling Water-Resistant Bioadhesion and Stem Cell Encapsulation

ACS Applied Bio Materials, v. 1, (5), November 2018, p. 1735-1740
Luo, Jiren; Liu, Xiaotian; Yang, Zhongguang; Sun, Fei
Article

Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth

ACS Applied Nano Materials, v. 1, (4), March 2018, p. 1579-1585
Liu, Xiaotian; Yang, Xin; Yang, Zhongguang; Luo, jiren; Tian, xiaozhen; Liu, Kai; Kou, Songzi; Sun, Fei
Article

2017 4

B₁₂-Dependent Photoresponsive Protein Hydrogels for Controlled Stem Cell/Protein Release

Proceedings of the National Academy of Sciences of the United States of America, v. 114, (23), June 2017, p. 5912-5917
Wang, Ri; Yang, Zhongguang; Luo, Jiren; Hsing, I-Ming; Sun, Fei
Article

Entirely Recombinant Protein-based Hydrogels for Selective Heavy Metal Sequestration

POLYMER CHEMISTRY, v.8, (39), October 2017, p. 6158-6164
Kou, Songzi; Yang, Zhongguang; Luo, Jiren; Sun, Fei
Article

Protein Hydrogel Microbeads for Selective Uranium Mining from Seawater

ACS Applied Materials and Interfaces, v. 9, (3), January 2017, p. 2035-2039
Kou, Songzi; Yang, Zhongguang; Sun, Fei
Article

Unleashing Chemical Power From Protein Sequence Space Toward Genetically Encoded “click” Chemistry

Chinese Chemical Letters, v. v. 28, ((11)), 2017, p. 2078-2084
Sun, Fei; Zhang, Wen-Bin
Article

2016 1

Microfluidics and Microbial Engineering

Lab on a Chip - Miniaturisation for Chemistry and Biology, v. 16, (3), February 2016, p. 432-446
Kou, Songzi; Cheng, Danhui; Sun, Fei; Hsing, I-Ming
Article

2015 1

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo

Chemistry & Biology, v. 22, (8), August 2015, p. 1108-1121
Bedbrook, Claire; Kato, Mihoko; Kumar, Sripriya Ravindra; Lakshmanan, Anupama; Nath, Ravi D.; Sun, Fei; Sternberg, Paul W.; Arnold, Frances H.; Gradinaru, Viviana
Article

2014 2

Steady-State Hydrogen Peroxide Induces Glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa

Journal of Bacteriology, v. 196, (14), 2014, p. 2499-2513
Deng, Xin; Liang, Haihua; Ulanovskaya, Olesya A.; Ji, Quanjiang; Zhou, Tianhong; Sun, Fei; Lu, Zhike; Hutchison, Alan L.; Lan, Lefu; Wu, Min; Cravatt, Benjamin F.; He, Chuan
Article

Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry

Proceedings of the National Academy of Sciences of the United States of America, v. 111, (31), August 2014, p. 11269-11274
Sun, Fei; Zhang, Wen-Bin; Mahdavi, Alborz; Arnold, Frances H.; Tirrell, David A.
Article

2013 3

Controlling Macromolecular Topology with Genetically Encoded SpyTag-SpyCatcher Chemistry

Journal of the American Chemical Society, v. 135, (37), September 2013, p. 13988-13997
Zhang, Wen-Bin; Sun, Fei; Tirrell, David A.; Arnold, Frances H.
Article

Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR

Proceedings of the National Academy of Sciences of the United States of America, v. 110, (13), March 2013, p. 5010-5015
Ji, Quanjiang; Zhang, Liang; Jones, Marcus B.; Sun, Fei; Deng, Xin; Liang, Haihua; Cho, Hoonsik; Brugarolas, Pedro; Gao, Yihe N.; Peterson, Scott N.; Lan, Lefu; Bae, Taeok; He, Chuan
Article

Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria

Cell Host and Microbe, v. 13, (3), March 2013, p. 358-370
Deng, Xin; Weerapana, Eranthie; Ulanovskaya, Olesya; Sun, Fei; Liang, Haihua; Ji, Quanjiang; Ye, Yan; Fu, Ye; Zhou, Lu; Li, Jiaxin; Zhang, Haiyan; Wang, Chu; Alvarez, Sophie; Hicks, Leslie M.; Lan, Lefu; Wu, Min; Cravatt, Benjamin F.; He, Chuan
Article

2012 6

AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus

J Am Chem Soc., v.134, (1), 11 Jan 2012, p. 305-314
Sun, Fei; Ji, Quanjiang; Jones, Marcus B.; Deng, Xin; Liang, Haihua; Frank, Bryan; Telser, Joshua; Peterson, Scott N.; Bae, Taeok; He, Chuan
Article

Expression of Multidrug Resistance Efflux Pump Gene norA Is Iron Responsive in Staphylococcus aureus

J. Bacteriol, v.194, (7), 2012, April, p. 1753-1762
Deng, Xin; Sun, Fei; Ji, Quanjiang; Liang, Haihua; Missiakas, Dominique; Lan, Lefu; He, Chuan
Article

Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance

Proc Natl Acad Sci U S A., v.109, (38), 18 September 2012, p. 15461-15466
Sun, F.; Ding, Y.; Ji, Q.; Liang, Z.; Deng, X.; Wong, CC; Yi, C.; Zhang, L.; Xie, S.; Alvarez, S.; Hicks, LM; Luo, C.; Jiang, H.; Lan, L.; He, C.
Article

Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA

Proc Natl Acad Sci U S A, v.109, (23), 14 June 2012, p. 9095-9100
Sun, Fei; Liang, Haihua; Kong, Xiangqian; Xie, Sherrie; Cho, Hoonsik; Deng, Xin; Ji, Quanjiang; Zhang, Haiyan; Alvarez, Sophie; Hicks, Leslie M.; Bae, Taeok; Luo, Cheng; Jiang, Hualiang; He, Chuan
Article

Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response

Journal of Biological Chemistry, v. 287, (25), June 2012, p. 21102-21109
Ji, Quanjiang; Zhang, Liang; Sun, Fei; Deng, Xeng; Liang, Haihua; Bae, Taeok; He, Chuan
Article

The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus

Molecular Microbiology, v.86, (2), 2012, Oct, p. 331–348
Jeong, Do-Won; Cho, Hoonsik; Jones, Marcus B.; Shatzkes, Kenneth; Sun, Fei; Ji, Quanjiang; Liu, Qian; Peterson, Scott N.; He, Chuan; Bae, Taeok
Article

2011 2

Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus

Chemistry & Biology, v.18, (8), 26 August 2011, p.1032–1041
Sun, Fei; Zhou, Lu; Zhao, Bing-Chuan; Deng, Xin; Cho, Hoonsik; Yi, Chengqi; Jian, Xing; Song, Chun-Xiao; Luan, Chi-Hao; Bae, Taeok; Liemail, Zigang; Heemail, Chuan
Article

The tightly regulated copper window in yeast

Chem. Commun, v.47, 2011, p. 2571-2573
Wegner, Seraphine V.; Sun, Fei; Hernandeza, Nick; He, Chuan
Article

2010 3

Aureusimines in Staphylococcus aureus are not involved in virulence

PLoS One, v.5, (12), 29 Dec 2010, article number e15703
Sun, Fei; Cho, Hoonsik; Jeong, Do-Won; Li, Chunling; He, Chuan; Bae, Taeok
Article

CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis

J. Bacteriol, v.192, (15), 2010, Aug, p. 3883-3892
Li, Chunling; Sun, Fei; Cho, Hoonsik; Yelavarthi, Vamshi; Sohn, Changmo; He, Chuan; Schneewind, Olaf; Bae, Taeok
Article

In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS

J Bacteriol, v.192, (8), 2010, Apr, p. 2111-2127
Sun, Fei; Li, Chunling; Jeong, Dowon; Sohn, Changmo; He, Chuan; Bae, Taeok
Article

BEHI5009	Protein Engineering
BIEN6800A	Bioengineering Seminar
CENG5610	Protein Engineering

BIEN4920	Bioengineering Capstone Design
BIEN4930	Bioengineering Thesis Research
BIEN6800Z	Bioengineering Seminar
ENEG4920	Final Year Design Project

BEHI5009	Protein Engineering
BIEN4920	Bioengineering Capstone Design
BIEN4930	Bioengineering Thesis Research
BIEN6800Y	Bioengineering Seminar
CENG4640	Biomolecular Engineering
ENEG4920	Final Year Design Project

Research Interest

Publications

2024 2

2023 2

2022 8

2021 6

2020 8

2019 2

2018 8

2017 4

2016 1

2015 1

2014 2

2013 3

2012 6

2011 2

2010 3

Article 2

Article 2

Article 8

Article 4

Book chapter 2

Article 7

Book chapter 1

Article 2

Article 8

Article 4

Article 1

Article 1

Article 2

Article 3

Article 6

Article 2

Article 3

2018 8

2017 4

2016 1

2015 1

2014 2

2013 3

2012 6

2011 2

2010 3

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

Current RPGs

Graduated RPGs

Projects

From January 2022 to December 2024

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