Faculty Profiles - LIANG Chun | The Hong Kong University of Science and Technology

Chun LIANG
梁純

PhD in Biology
Brown University, 1993

Associate Professor
Division of Life Science

(852) 2358 7296
bccliang@ust.hk
Room 5524
Personal Web

ORCID

0000-0003-1996-6027

Scopus ID

26026377400

Research Interest Publications Projects Teaching Assignment RPG Supervision Space used

Research Interest

Deoxyribonucleic acid (DNA) replication
Cell cycle control
Cancer
Biotechnology

Publications

All Years 109 2024 0 2023 8 2022 10 2021 3 2020 6 2019 5 2018 77

2023 8

An Essential Noc3p Dimerization Cycle Mediates ORC Double-Hexamer Formation in Replication Licensing

Life Science Alliance, v. 6, (3), March 2023, article number e202201594
Amin, Aftab; Wu, Rentian; Khan, Muhammad Ajmal; Cheung, Man Hei; Liang, Yanting; Liu, Changdong; Zhu, Guang; Yu, Zhi-Ling; Liang, Chun
Article

Molecular Pathology and Therapeutic Strategies of Type 2 Diabetes

Endocrine, Metabolic & Immune Disorders - Drug Targets, v. 23, (11), June 2023, p. 1392-1399
Liao, Helen Ziqing; Liang, Yanting; Wang, Ye; Liang, Chun
Article

中药复方馥感啉口服液对不同年龄段SD大鼠发育毒性

中國藥理學與毒理學雜誌=Chinese Journal of Pharmacology and Toxicology, v. 37, (12), December 2023, p. 895-903
郭健敏; 张文强; 邓应华; 蒙飞彪; 梁纯; 杨威
Article

芩香清解口服液对4日龄大鼠的发育毒性

中國藥理學與毒理學雜誌=Chinese Journal of Pharmacology and Toxicology, v. 37, (12), December 2023, p. 904-913
郭健敏; 张文强; 邓应华; 蒙飞彪; 谢松强; 梁纯; 杨威
Article

Development of innovative DNA replication initiation-protein inhibitors as broad-spectrum and highly active anti-tumor drugs

Liang, Chun
Conference paper

Development strategies and progress of innovative broad-spectrum and efficient anticancer drugs targeting DNA replication-initiation proteins (DRIPs)

Liang, Chun
Conference paper

Research and Development of Anticancer Drugs Targeting DNA Replication Initiation Proteins (DRIPs)

Liang, Chun
Conference paper

Research and Development of Tumor Drugs Targeting DNA Replication Initiation Proteins (DRIPs)

Liang, Chun
Conference paper

2022 10

Amelioration of TPA-induced skin inflammation by the leaf extract of Vernonia amygdalina involves ERK/STAT3 (Ser727) signaling inhibition

Phytomedicine, v. 102, July 2022, article number 154194
Wu, Jia-Ying; Xie, Jian-Hua; Chen, Ying-Jie; Fu, Xiu-Qiong; Wang, Rui-Jun; Deng, Yu-Yi; Wang, Shuo; Yu, Hai-Xia; Liang, Chun; Yu, Zhi-Ling
Article

Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models

Journal of Ginseng Research, v. 46, (3), 10 May 2022, p. 418-425
Chen, Ying-Jie; Wu, Jia-Ying; Deng, Yu-Yi; Wu, Ying; Wang, Xiao-Qi; Li, Amy Sze-man; Wong, Lut Yi; Fu, Xiu-Qiong; Yu, Zhi-Ling; Liang, Chun
Article

Inhibition of the Akt/NF-κB pathway is involved in the anti-gastritis effects of an ethanolic extract of the rhizome of Atractylodes macrocephala

Journal of Ethnopharmacology, v. 293, 15 July 2022, article number 115251
Amin, Aftab; Hossen, Muhammad Jahangir; Fu, Xiu-Qiong; Chou, Ji-Yao; Wu, Jia-Ying; Wang, Xiao-Qi; Chen, Ying-Jie; Wu, Ying; Yin, Cheng-Le; Dou, Xiao-Bing; Liang, Chun; Chou, Gui-Xin; Yu, Zhi-Ling
Article

Network Pharmacology Analysis of Bioactive Components and Mechanisms of Action of Qi Wei Wan Formula for Treating Non-Small Cell Lung Carcinoma

Natural Product Communications, v. 17, (10), October 2022, article number 1934578X221120215
Zhang, Minghe; Wang, Ye; Amin, Aftab; Khan, Muhammad Ajmal; Yu, Zhiling; Liang, Chun
Article

pPeOp inhibits HGC-27 cell proliferation, migration and invasion by upregulating miR-30b-5p and down-regulating the Rac1/ Cdc42 pathway

Acta Biochimica et Biophysica Sinica, v. 54, (12), December 2022, p. 1897-1908
Xu, Wenjun; Fu, Zhenjie; Xu, Yuqin; Cheung, Man Hei; Chen, Yan; Lin, Meiai; Wen, Hang; Lv, Hang; Liang, Chun; Lou, Jianshu; Chen, Yitao
Article

Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells

Cancer Letters, v. 539, 28 July 2022, article number 215677
Wang, Jun; Amin, Aftab; Cheung, Man Hei; Shi, Linjing; Liang, Chun
Article

Tea and Tea Drinking: China’s Outstanding Contributions to the Mankind

Chinese Medicine (United Kingdom), v. 17, (1), February 2022, article number 27
Pan, Si-Yuan; Nie, Qu; Tai, Hai-Chuan; Song, Xue-Lan; Tong, Yu-Fan; Zhang, Long-Jian-Feng; Wu, Xue-Wei; Lin, Zhao-Heng; Zhang, Yong-Yu; Ye, Du-Yun; Zhang, Yi; Wang, Xiao-Yan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Liang, Chun
Article

抗原受体-T 细胞治疗多发性骨髓瘤研究进展

中国药理学与毒理学杂志=Chinese Journal of Pharmacology and Toxicology, v. 36, (9), September 2022, p. 680-690
吴琪琪; 郭健敏; 梁純; 杨威
Article

连翘苷体内外抗病毒及解热作用机制

中国药理学通报=Chinese Pharmacological Bulletin, v. 38, (8), August 2022, p. 1170-1175
郭健敏; 富力; 秦丽莉; 陈文培; 代彩玲; 梁纯; 吴琪琪; 杨威
Article

Research and Development of innovative DNA replication initiation protein (DRIPs) inhibitors as broad-spectrum and high-efficiency tumor drugs

Liang, Chun
Conference paper

2021 3

A two-herb formula inhibits STAT3 signaling and exerts anti-melanoma effects in cell and animal models

Journal of Ethnopharmacology, v. 268, March 2021, article number 113671
Li, Jun Kui; Chou, Ji Yao; Yin, Cheng Le; Fu, Xiu Qiong; Wu, Ying; Chen, Ying Jie; Bai, Jing Xuan; Wu, Jia Ying; Liang, Chun; Yu, Zhi Ling
Article

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Evidence-based Complementary and Alternative Medicine, v. 2021, June 2021, article number 6610793
Han, Zhong; Guo, Jianmin; Meng, Feibiao; Liao, Haifeng; Deng, Yinghua; Huang, Yuankeng; Lei, Xialing; Liang, Chun; Han, Richou; Yang, Wei
Article

The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition

Journal of Ethnopharmacology, v. 277, September 2021, article number 114183
Hossen, Muhammad Jahangir; Amin, Aftab; Fu, Xiu-Qiong; Chou, Ji-Yao; Wu, Jia-Ying; Wang, Xiao-Qi; Chen, Ying-Jie; Wu, Ying; Li, Junkui; Yin, Cheng-Le; Liang, Chun; Chou, Gui-Xin; Yu, Zhi-Ling
Article

2020 6

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication

Cell Reports, v. 30, (10), March 2020, article number E6, p. 3323-3338
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John F.; Wang, Ziyi; Zhou, Zijing; Liu, Changdong; Zhu, Guang; Wong, Chris Kong Chu; Yu, Zhiling; Liang, Chun
Article

FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly

Frontiers in Cell and Developmental Biology, v. 8, November 2020, article number 590449
Jiang, Huadong; Liu, Shanshan; Cheung, Man Hei; Amin, Aftab; Liang, Chun
Article

Gynura divaricata exerts hypoglycemic effects by regulating the PI3K/AKT signaling pathway and fatty acid metabolism signaling pathway

Nutrition and Diabetes, v. 10, (1), 1 December 2020, article number 31
Xu, Wenjun; Lu, Zhongxia; Wang, Xin; Cheung, Man Hei; Lin, Meiai; Li, Changyu; Dong, Yu; Liang, Chun; Chen, Yitao
Article

Inhibiting the Src/STAT3 signaling pathway contributes to the anti-melanoma mechanisms of dioscin

Oncology Letters, v. 19, (3), January 2020, p. 2508-2514
Liu, Yu-Xi; Xu, Bo-Wen; Chen, Ying-Jie; Fu, Xiu-Qiong; Zhu, Pei-Li; Bai, Jing-Xuan; Chou, Ji-Yao; Yin, Cheng-Le; Li, Jun-Kui; Wang, Ya-Ping; Wu, Jia-Ying; Wu, Ying; Chan, Kam-Kwan; Liang, Chun; Yu, Zhiling
Article

Parameritannin A-2 from Urceola huaitingii enhances doxorubicin-induced mitochondria-dependent apoptosis by inhibiting the PI3K/Akt, ERK1/2 and p38 pathways in gastric cancer cells

Chemico-Biological Interactions, v. 316, January 2020, article number 108924
Liang, Lu; Amin, Aftab; Cheung, Wing Yan; Xu, Rui; Yu, Rujian; Tang, Jinshan; Yao, Xinsheng; Liang, Chun
Article

Research and development of innovative anticancer drugs targeting DNA Replication-Initiation Proteins

Liang, Chun
Conference paper

2019 5

DNA Replication-Initiation Proteins in Eukaryotic Cells

Biomedical Journal of Scientific & Technical Research, v. 23, (1), November 2019, p. 17042-17049
Amin, Aftab; Cheung, Man Hei; Liang, Chun
Article

Human NOC3 is essential for DNA replication licensing in human cells

Cell Cycle, v. 18, (5), March 2019, p. 605-620
Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Yu, Zhiling; Liang, Chun
Article

Identification of Molecular Biomarkers for the Diagnosis of Gastric Cancer and Lymph-node Metastasis

Gastroenterology Report, v. 7, (1), February 2019, p. 57-66
Seeruttun, Sharvesh Raj; Cheung, Wing Yan; Wang, Wei; Fang, Cheng; Liu, Zhimin; Li, Jinqing; Wu, Ting; Wang, Jun; Liang, Chun; Zhou, Zhiwei
Article

Reproductive Systemic Toxicity and Mechanism of Glucosides of Tripterygium wilfordii Hook. F. (GTW)

Annals of Clinical and Laboratory Science, v. 49, (1), January 2019, p. 36-49
Guo, Jianmin; Huang, Yuankeng; Lei, Xialing; Zhang, Hong; Xiao, Baiquan; Han, Zhong; Liang, Chun; Yang, Wei
Article

The Interaction Networks of the Budding Yeast and Human DNA Replication-initiation Proteins

Cell Cycle, v. 18, (6-7), April 2019, p. 723-741
Wu, Rentian; Amin, Aftab; Wang, Ziyi; Huang, Yining; Cheung, Man Hei; Yu, Zhiling; Yang, Wei; Liang, Chun
Article

2018 6

Biomarkers associated with binaprofen‑induced liver injury

Molecular Medicine Reports, v.18, (6), December 2018, p. 5076-5086
Guo, Qiuping; Guo, Jianmin; Chen, Guiying; Han, Zhong; Xiao, Baiquan; Jin, Ruomin; Liang, Chun; Yang, Wei
Article

Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway

Evidence-based Complementary and Alternative Medicine, v. 2018, 2018, article number 6356190, p. 1-12
Wu, Hai-wang; Feng, Yi-hui; Wang, Dong-ying; Qiu, Wei-yu; Yu, Qing-ying; Yang, Li-lin; Liang, Chun; Luo, Song-ping; Gao, Jie
Article

Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways

Scientific Reports, v. 8, (1), November 2018, article number 17342
Gao, Feixia; Zhou, Chun; Qiu, Weiyu; Wu, Haiwang; Li, Jing; Peng, Jinting; Qiu, Min; Liang, Chun; Gao, Jie; Luo, Songping
Article

雷公藤多苷对雄性SD大鼠生殖系统损伤的动态变化及其可能机制

中国药理学与毒理学杂志=Chinese Journal of Pharmacology and Toxicology, v. 32, (6), June 2018, p. 469-476
郭健敏; 黄远铿; 雷夏凌; 韩重; 梁純; 杨威
Article

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle regulates eukaryotic chromosomal DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Liang, Chun
Conference paper

Rrp12 Functions as a Novel DNA Replication Initiation Protein

Yu, Zhiling; Amin, Aftab; Liang, Chun
Conference paper

2017 4

Mitoxantrone Suppresses Vascular Smooth Muscle Cell (VSMC) Proliferation and Balloon Injury-induced Neointima Formation: An in Vitro and in Vivo Study

Bosnian Journal of Basic Medical Sciences, v. 17, (4), November 2017, p. 339-348
Teng, Yuan; Wang, Ziyi; Li, Wen; Yu, Jianxing; Shan, Zhen; Liang, Chun; Wang, Shenming
Article

A Role of NOC3 in DNA Replication Initiation in Human Cells

Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Zhong, Shan; Liang, Chun
Conference paper

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Zhou, Zijing; Wang, Ziyi; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun
Conference paper

An essential, cell cycle-dependent and semi-conservative ORC dimerization cycle critically regulates DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun
Conference paper

2016 3

A Role of hIPI3 in DNA Replication Licensing in Human Cells

PLoS ONE, v. 11, (4), April 2016, article number e0151803
Huang, Yining; Amin, Aftab; Qin, Yan; Wang, Ziyi; Jiang, Huadong; Liang, Lu; Shi, Linjing; Liang, Chun
Article

Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics

Fitoterapia, v. 112, July 2016, p. 175-182
Yu, Rujian; Liu, Haibin; Yu, Yang; Liang, Lu; Xu, Rui; Liang, Chun; Tang, Jinshan; Yao, Xinsheng
Article

Asperosaponin VI Promotes Progesterone Receptor Expression in Decidual Cells via the Notch Signaling Pathway

Fitoterapia, v. 113, September 2016, p. 58-63
Gao, Jie; Zhou, Chun; Li, Yadi; Gao, Feixia; Wu, Haiwang; Yang, Lilin; Qiu, Weiyu; Zhu, Lin; Du, Xin; Lin, Weixian; Huang, Dandan; Liu, Haibin; Liang, Chun; Luo, Songping
Article

2015 2

Regulation of DNA replicaiton in normal and cancer cells and cancer metasatsis mechanisms

Liang, Chun
Conference paper

The Capillary Number Effect on the Capture Efficiency of Cancer Cells on Composite Microfluidic Filtration Chips

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), v. 2015-February, (February), February 2015, article number 7050989, p. 459-462
Zhao, Cong; Xu, Rui; Song, Kui; Liu, Dayu; Ma, Shou; Tang, Chen; Liang, Chun; Zohar, Yitshak; Lee, Yi-kuen
Conference paper

2014 3

Isolation of circulating tumor cells under hydrodynamic loading using microuidic technology

力学进展=Advances in Mechanics, v .44, (1), January 2014, p. 447-494
Zhao, Cong; Lee, Yi-Kuen; Xu, Rui; Liang, Chun; Liu, Dayu; Ma, Wei; Piyawattanmetha, Wibool; Zohar, Yitshak
Article

MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer

Molecular Cancer Research, v. 12, (11), November 2014, p. 1535-1546
Zhang, Xin; Xiao, Dakai; Wang, Ziyi; Zou, Yongxin; Huang, Liyan; Lin, Weixuan; Deng, Qiuhua; Pan, Hui; Zhou, Jiangfen; Liang, Chun; He, Jianxing
Article

Regulation of DNA Replication in Normal and Cancer Cells

Liang, Chun
Conference paper

2013 3

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication

Wu, Rentian; Zhou, Zijing; Wang, Jiafeng; Amin, Aftab; Wang, Ziyi; Liang, Chun
Conference paper

Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Applications In Cancer

Liang, Chun
Conference paper

Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Clinical Applications

Liang, Chun
Conference paper

2012 3

Cdt1p, through its interaction with Mcm6P, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex

Journal of cell science, v. 125, (1), 2012, p. 209-219
Wu, Rentian; Wang, Jiafeng; Liang, Chun
Article

Structural insights into the Cdt1-mediated MCM2-7 chromatin loading

Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang
Article

The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis

Cell cycle, v. 11, (7), 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, TszChoi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun
Article

2011 3

APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

PLoS ONE, v. 6, (10), October 2011, article number e24669
Geng, Hua; Law, Peggy P.Y.; Ng, Maggie C.Y.; Li, Ting; Liang, Li-Yun; Ge, Tian-Fang; Wong, Kam-Bo; Liang, Chun; Ma, Ronald C.; So, Wing-Yee; Chan, Juliana C.N.; Ho, Yuan-Yuan
Article

Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast

FEMS yeast research, v. 11, (1), 2011, p. 72-79
Lai, Fenju; Wu, Rentian; Wang, Jiafeng; Li, Chunming; Zou, Lan; Lu, Yongjun; Liang, Chun
Article

Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast

Fundamental Aspects of DNA Replication / Edited by Jelena Kušić-Tišma, Croati: InTech Publisher, Chapter 6, p. 87-106
Zhai, Yuanliang; Yung, Philip; Liang, Chun
Book chapter

2010 10

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast

Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun
Article

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Journal of cell science, v. 123, (22), 2010, p. 3933-3943
Zhai, Yuanliang; Yung, P.Y.K.; Huo, Lin; Liang, Chun
Article

Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6

Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang
Article

Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast

Biochemical and biophysical research communications, v. 395, (3), 2010, MAY 7, p. 336-341
Wang, Jiafeng; Wu, Rentian; Lu, Yongjun; Liang, Chun
Article

Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae

Cell Cycle, v. 9, (21), 2010, Nov, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, TszChoi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun
Article

The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells

Cell Cycle, v. 9, (24), 2010, p. 4848-4857
Zhang, Jing; Yu, Lan; Wu, Xing; Zou, Lan; Sou, K.K.L.; Wei, Zhun; Cheng, Xue; Zhu, Guang; Liang, Chun
Article

A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome

James Watson Symposium on Cancer, Cold Spring Harbor Asia Conferences, Suzhou, China, April 2010
Kan, Junsuo; Wang, Ziyi; Tu, Zheng; Zhang, Jingjing; Wu, Xing; Liang, Chun
Conference paper

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun
Conference paper

Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast

Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun
Conference paper

Nuclear Matrix Association of Orc and Utp7P is Inter-Dependent, Cell Cycle-Regulated, and required for Pre-Replicative Complex Assembly in Budding Yeast

Cold Spring Harbor Lab 'The Cell Cycle' Meeting, Cold Spring Harbor Lab, N. Y., USA, 5/2010
Cheng, Xue; Wang, Jiafeng; Xu, Zhen; Liang, Chun
Conference paper

2009 3

Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma

Mutation research-fundamental and MOLECULAR MECHANISMS OF Mutagenesis, v. 662, (1-2), 2009, MAR 9, p. 10-15
Xiong, Xing-Dong; Qiu, Fu-En; Fang, Jian-Hong; Shen, Yi; Liang, Chun; Jiang, Wenqi; Zhuang, Shi-Mei
Article

A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome

The Cold Spring Harbor Lab 'Eukaryotic DNA Replication & Genome Maintenance' Meeting, Cold Spring Harbor Lab, N.Y. USA, 09/2009
Kan, Junsuo; Wang, Ziyi; Tu, Zhen; Wu, Xing; Liang, Chun
Conference paper

Identification of the functional domains involved in the interaction between human Cdt1 and Mcm6

The Cold Spring Harbor Lab “Eukaryotic DNA Replication & Genome Maintenance” Meeting, Cold Spring Harbor Lab, N.Y., USA, 9/2009
Zhang, Jingjing; Wu, Xing; Yu, Lan; Wei, Zhun; Zou, Lan; Zhu, Guang; Liang, Chun
Conference paper

2008 5

Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80, and Itself

Journal of virology, v. 82, (24), 2008, DEC 15, p. 12356-12364
Wu, Wenbi; Liang, Hanquan; Kan, Junsuo; Liu, Chao; Yuan, Meijin; Liang, Chun; Yang, Kai; Pang, Yi
Article

mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue

BMC cancer, v. 8, 2008, DEC 30
Li, Jian-na; Feng, Chong-jin; Lu, Yong-jun; Li, Hui-jun; Tu, Zheng; Liao, Guiqing; Liang, Chun
Article

Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae

Journal of biological chemistry, v. 283, (49), 2008, DEC 5, p. 33803-33807
Kan, Junsuo; Zou, Lan; Zhang, Jingjing; Wu, Rentian; Wang, Ziyi; Liang, Chun
Article

The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis

The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun
Conference paper

The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis

11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun
Conference paper

2006 3

Ecdysone induces transcription and amplification in Sciara coprophila DNA puff II/9A

Developmental Biology Biol, v. 299, (1), 2006, p. 151-163
Foulk, Michael S.; Liang, Chun; Wu, Nan; Blitzblau, Hannah G.; Smith, Heidi S.; Alam, Daniel; Batra, Maneesh; Gerbi, Susan A.
Article

Ipi3p is an essential DNA replication-initiation protein required for and directly involved in pre-replication complex assembly and maintenance (Talk)

The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2006
Huo, Lin; Yu, Zhiling; Chan, Tsz Choi; Lu, Yongjun; Zhang, Yuan; Wong, Bonnie; Labib, Karim; Liang, Chun
Conference paper

RRP12 plays an essential and direct role in the initiation of DNA replication in budding yeast

The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 5.2006
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun
Conference paper

2005 5

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun
Conference paper

Ipi3, a novel replication-initiation protein identified by the IDR (Initiation of DNA Replication) screen with td (temperature-sensitive degron) mutants.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Huo, Lin; Chan, Tsz Choi; Yu, Zhiling; Wong, Bonny Y.M.; Lu, Yongjun; Labib, Karim; Liang, Chun
Conference paper

Noc3p, Rrp12p and Ipi3p, a Group of Proteins Involved in Both the Initiation of DNA Replication and Ribosome Biogenesis. (Invited talk)

eIMBL Video Conference on DNA Replication, 11.2005
Liang, Chun
Conference paper

Rrp12 plays an essential and direct role in the initiation of DNA replication in budding yeast.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun
Conference paper

The human homolog of the yeast Noc3 is required for DNA replication in human cells.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zou, Sally Lan; Hu, Yun; Wu, Jingwen; Wu, Xing; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun
Conference paper

2004 4

Pairwise interactions of the six human MCM protein subunits

Journal of Molecular Biology, v. 340, (5), 2004, JUL 23, p. 1197-1206
Yu, Zhiling; Feng, Daorong; Liang, C.
Article

Pairwise Interactions of the Six Human MCM Protein Subunits

The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Yu, Zhiling; Feng, Daorong; Liang, Chun
Conference paper

RT-PCR Detection of Bladder Carcinoma in Voided Urine Cells using DNA Replication-initiation proteins as the Markers

The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Tu, Zheng; Tong, Tommy Sw; Li, Kamming; Huo, Lin; Sou, Kelvin K.L.; Liang, Chun
Conference paper

Studies on the Human Homolog of the Yeast Noc3 in Human Cells

9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, Crete,Greece, 10.2004;
Zou, Lan; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun
Conference paper

2003 4

Cdc48p is required for the cell cycle commitment point at start via degradation of the G1-CDK inhibitor Far1p

Journal of Cell Biology, v. 163, (1), 2003, OCT 13, p. 21-26
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun
Article

Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells

Cancer research, v. 63, (21), 2003, NOV 1, p. 7356-7364
Feng, Daorong; Tu, Zheng; Wu, Wenyan; Liang, Chun
Article

A Novel Phenotypic screen for Dna replication-Initiations in Saccharomyces cerevisiae: the IDR (Initiation of DNA Replication) Screen

Chan, Tsz Choi; Lu, Yongjun; Fu, Xinrong; Leung, Ivy; Lu, Gan; Zhai, Yanliang; Yu, Zhiling; Liang, Chun
Conference paper

Cdc48p, an AAA-family protein, is required for both the initiation of DNA replication and cell cycle control at START in budding yeast

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab., USA, Sept
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun
Conference paper

2002 4

A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara

Chromosoma, v. 111, (5), 2002, p. 291-303
Urnov, Fyodor D.; Liang, Chun; Blitzblau, Hannah G.; Smith, Heidi S.; Gerbi, Susan A.
Article

Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast

Cell, v. 109, (7), 2002, JUN 28, p. 849-860
Zhang, Yuexuan; Yu, Zhiling; Fu, Xinrong; Liang, Chun
Article

DNA replication and cancer

5th Conference of the Asia-Pacific International Molecular Biology Network, Shanghai, China, p. 23
Liang, Chun
Conference paper

Identification and characterization of novel initiation proteins for DNA replication in budding yeast

FASEB Summer Research Conference on Yeast Chromosome Structure, Replication and Segregation, Snowmass, Colorado, USA.
Liang, Chun; Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry
Conference paper

2001 4

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle

Proceedings of the National Academy of Sciences of the United States of America, v. 98, (20), 2001, p. 11211-11217
Weinreich, Michael D.; Liang, Chun; Chen, Hsuhsin; Stillman, Bruce W.
Article

DNA replication and cancer

Asia-med, 5: 61-65
Liang, Chun; Fu, Xinrong; Zhang, Yuexuan; Lu, Yongjun; Feng, Doarong; Li, Kamming; Yu, Zhiling; Sou, Kelvin
Article

Initiation proteins for DNA replication in normal and cancer cells

Molecular Genetic Basis of Cancer / Edited by M.L. Lung and W.L.W. Hsiao., published by HKUST, p. 316-324
Liang, Chun
Book chapter

Identification and characterization of previously unknown replication initiation proteins in S. cerevisiae

Eukaryotic DNA Replication, Cold Spring Harbor Laboratory, New York, USA
Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry; Liang, Chun
Conference paper

1999 2

The Cdc6p nucleotide binding motif is required for loading Mcm proteins onto chromatin

Proceedings of the National Academy of Sciences of the United States of America, v. 96, (2), Jan, 1999, p. 441-446
Weinreich, Michael D.; Liang, Chun; Stillman, Bruce W.
Article

Methods to map origins of replication in eukaryotes

Eukaryotic DNA Replication: A Practical Approach / Edied by S. Cotterill., Oxford University Press, Chapter 1, 1999, p. 1-42.
Gerbi, S.A.; Bielinsky, A.; Liang, Chun; Lunyak, V.; Urnov, F.
Book chapter

1997 1

Persistent initiation of DNA replication and chromatin bound MCM proteins during the cell cycle in cdc6 mutants

Genes and Development, v. 11, (24), 1997, p. 3375-3386
Liang, Chun; Stillman, Bruce W.
Article

1995 1

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

Cell, v. 81, 1995, p. 667-676
Liang, Chun; Weinreich, Michael D.; Stillman, Bruce W.
Article

1994 1

Analysis of an origin of DNA amplification in Sciara coprophila using a novel three-dimensional gel method

Molecular and Cellular Biology, v. 14, (2), 1994, p. 1520-1529
Liang, Chun; Gerbi, Susan A.
Article

1993 3

Developmental progression in Sciara coprophila DNA puffs: DNA amplification and transcription

Developmental Biology, v. 160, (1), November 1993, p. 73-84
Wu, Nan; Liang, Chun; Smith, Heidi S.; Dibartolomeis, Susan M.; Gerbi, Susan A.
Article

DNA amplification in DNA puff II/9A of Sciara coprophila.

Cold Spring Harbor Symposia on Quantitative Biology, v. 58, 1993, p. 487-494
Gerbi, Susan A.; Liang, Chun; Wu, Nan; DiBartolomeis, Susan M.; Bienz-Tadmor, Brigitte; Smith, Heidi S.; Urnov, Fyodor D.
Article

Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A

Genes and Development, v. 7, (6), 1993, p. 1072-1084
Liang, Chun; Spitzer, Josephine D.; Smith, Heidi S.; Gerbi, Susan A.
Article

Article 4

An Essential Noc3p Dimerization Cycle Mediates ORC Double-Hexamer Formation in Replication Licensing

Life Science Alliance, v. 6, (3), March 2023, article number e202201594
Amin, Aftab; Wu, Rentian; Khan, Muhammad Ajmal; Cheung, Man Hei; Liang, Yanting; Liu, Changdong; Zhu, Guang; Yu, Zhi-Ling; Liang, Chun

Molecular Pathology and Therapeutic Strategies of Type 2 Diabetes

Endocrine, Metabolic & Immune Disorders - Drug Targets, v. 23, (11), June 2023, p. 1392-1399
Liao, Helen Ziqing; Liang, Yanting; Wang, Ye; Liang, Chun

中药复方馥感啉口服液对不同年龄段SD大鼠发育毒性

中國藥理學與毒理學雜誌=Chinese Journal of Pharmacology and Toxicology, v. 37, (12), December 2023, p. 895-903
郭健敏; 张文强; 邓应华; 蒙飞彪; 梁纯; 杨威

芩香清解口服液对4日龄大鼠的发育毒性

中國藥理學與毒理學雜誌=Chinese Journal of Pharmacology and Toxicology, v. 37, (12), December 2023, p. 904-913
郭健敏; 张文强; 邓应华; 蒙飞彪; 谢松强; 梁纯; 杨威

Conference paper 4

Development of innovative DNA replication initiation-protein inhibitors as broad-spectrum and highly active anti-tumor drugs

Liang, Chun

Development strategies and progress of innovative broad-spectrum and efficient anticancer drugs targeting DNA replication-initiation proteins (DRIPs)

Liang, Chun

Research and Development of Anticancer Drugs Targeting DNA Replication Initiation Proteins (DRIPs)

Liang, Chun

Research and Development of Tumor Drugs Targeting DNA Replication Initiation Proteins (DRIPs)

Liang, Chun

Article 9

Amelioration of TPA-induced skin inflammation by the leaf extract of Vernonia amygdalina involves ERK/STAT3 (Ser727) signaling inhibition

Phytomedicine, v. 102, July 2022, article number 154194
Wu, Jia-Ying; Xie, Jian-Hua; Chen, Ying-Jie; Fu, Xiu-Qiong; Wang, Rui-Jun; Deng, Yu-Yi; Wang, Shuo; Yu, Hai-Xia; Liang, Chun; Yu, Zhi-Ling

Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models

Journal of Ginseng Research, v. 46, (3), 10 May 2022, p. 418-425
Chen, Ying-Jie; Wu, Jia-Ying; Deng, Yu-Yi; Wu, Ying; Wang, Xiao-Qi; Li, Amy Sze-man; Wong, Lut Yi; Fu, Xiu-Qiong; Yu, Zhi-Ling; Liang, Chun

Inhibition of the Akt/NF-κB pathway is involved in the anti-gastritis effects of an ethanolic extract of the rhizome of Atractylodes macrocephala

Journal of Ethnopharmacology, v. 293, 15 July 2022, article number 115251
Amin, Aftab; Hossen, Muhammad Jahangir; Fu, Xiu-Qiong; Chou, Ji-Yao; Wu, Jia-Ying; Wang, Xiao-Qi; Chen, Ying-Jie; Wu, Ying; Yin, Cheng-Le; Dou, Xiao-Bing; Liang, Chun; Chou, Gui-Xin; Yu, Zhi-Ling

Network Pharmacology Analysis of Bioactive Components and Mechanisms of Action of Qi Wei Wan Formula for Treating Non-Small Cell Lung Carcinoma

Natural Product Communications, v. 17, (10), October 2022, article number 1934578X221120215
Zhang, Minghe; Wang, Ye; Amin, Aftab; Khan, Muhammad Ajmal; Yu, Zhiling; Liang, Chun

pPeOp inhibits HGC-27 cell proliferation, migration and invasion by upregulating miR-30b-5p and down-regulating the Rac1/ Cdc42 pathway

Acta Biochimica et Biophysica Sinica, v. 54, (12), December 2022, p. 1897-1908
Xu, Wenjun; Fu, Zhenjie; Xu, Yuqin; Cheung, Man Hei; Chen, Yan; Lin, Meiai; Wen, Hang; Lv, Hang; Liang, Chun; Lou, Jianshu; Chen, Yitao

Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells

Cancer Letters, v. 539, 28 July 2022, article number 215677
Wang, Jun; Amin, Aftab; Cheung, Man Hei; Shi, Linjing; Liang, Chun

Tea and Tea Drinking: China’s Outstanding Contributions to the Mankind

Chinese Medicine (United Kingdom), v. 17, (1), February 2022, article number 27
Pan, Si-Yuan; Nie, Qu; Tai, Hai-Chuan; Song, Xue-Lan; Tong, Yu-Fan; Zhang, Long-Jian-Feng; Wu, Xue-Wei; Lin, Zhao-Heng; Zhang, Yong-Yu; Ye, Du-Yun; Zhang, Yi; Wang, Xiao-Yan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Liang, Chun

抗原受体-T 细胞治疗多发性骨髓瘤研究进展

中国药理学与毒理学杂志=Chinese Journal of Pharmacology and Toxicology, v. 36, (9), September 2022, p. 680-690
吴琪琪; 郭健敏; 梁純; 杨威

连翘苷体内外抗病毒及解热作用机制

中国药理学通报=Chinese Pharmacological Bulletin, v. 38, (8), August 2022, p. 1170-1175
郭健敏; 富力; 秦丽莉; 陈文培; 代彩玲; 梁纯; 吴琪琪; 杨威

Conference paper 1

Research and Development of innovative DNA replication initiation protein (DRIPs) inhibitors as broad-spectrum and high-efficiency tumor drugs

Liang, Chun

Article 3

A two-herb formula inhibits STAT3 signaling and exerts anti-melanoma effects in cell and animal models

Journal of Ethnopharmacology, v. 268, March 2021, article number 113671
Li, Jun Kui; Chou, Ji Yao; Yin, Cheng Le; Fu, Xiu Qiong; Wu, Ying; Chen, Ying Jie; Bai, Jing Xuan; Wu, Jia Ying; Liang, Chun; Yu, Zhi Ling

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Evidence-based Complementary and Alternative Medicine, v. 2021, June 2021, article number 6610793
Han, Zhong; Guo, Jianmin; Meng, Feibiao; Liao, Haifeng; Deng, Yinghua; Huang, Yuankeng; Lei, Xialing; Liang, Chun; Han, Richou; Yang, Wei

The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition

Journal of Ethnopharmacology, v. 277, September 2021, article number 114183
Hossen, Muhammad Jahangir; Amin, Aftab; Fu, Xiu-Qiong; Chou, Ji-Yao; Wu, Jia-Ying; Wang, Xiao-Qi; Chen, Ying-Jie; Wu, Ying; Li, Junkui; Yin, Cheng-Le; Liang, Chun; Chou, Gui-Xin; Yu, Zhi-Ling

Article 5

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication

Cell Reports, v. 30, (10), March 2020, article number E6, p. 3323-3338
Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John F.; Wang, Ziyi; Zhou, Zijing; Liu, Changdong; Zhu, Guang; Wong, Chris Kong Chu; Yu, Zhiling; Liang, Chun

FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly

Frontiers in Cell and Developmental Biology, v. 8, November 2020, article number 590449
Jiang, Huadong; Liu, Shanshan; Cheung, Man Hei; Amin, Aftab; Liang, Chun

Gynura divaricata exerts hypoglycemic effects by regulating the PI3K/AKT signaling pathway and fatty acid metabolism signaling pathway

Nutrition and Diabetes, v. 10, (1), 1 December 2020, article number 31
Xu, Wenjun; Lu, Zhongxia; Wang, Xin; Cheung, Man Hei; Lin, Meiai; Li, Changyu; Dong, Yu; Liang, Chun; Chen, Yitao

Inhibiting the Src/STAT3 signaling pathway contributes to the anti-melanoma mechanisms of dioscin

Oncology Letters, v. 19, (3), January 2020, p. 2508-2514
Liu, Yu-Xi; Xu, Bo-Wen; Chen, Ying-Jie; Fu, Xiu-Qiong; Zhu, Pei-Li; Bai, Jing-Xuan; Chou, Ji-Yao; Yin, Cheng-Le; Li, Jun-Kui; Wang, Ya-Ping; Wu, Jia-Ying; Wu, Ying; Chan, Kam-Kwan; Liang, Chun; Yu, Zhiling

Parameritannin A-2 from Urceola huaitingii enhances doxorubicin-induced mitochondria-dependent apoptosis by inhibiting the PI3K/Akt, ERK1/2 and p38 pathways in gastric cancer cells

Chemico-Biological Interactions, v. 316, January 2020, article number 108924
Liang, Lu; Amin, Aftab; Cheung, Wing Yan; Xu, Rui; Yu, Rujian; Tang, Jinshan; Yao, Xinsheng; Liang, Chun

Conference paper 1

Research and development of innovative anticancer drugs targeting DNA Replication-Initiation Proteins

Liang, Chun

Article 5

DNA Replication-Initiation Proteins in Eukaryotic Cells

Biomedical Journal of Scientific & Technical Research, v. 23, (1), November 2019, p. 17042-17049
Amin, Aftab; Cheung, Man Hei; Liang, Chun

Human NOC3 is essential for DNA replication licensing in human cells

Cell Cycle, v. 18, (5), March 2019, p. 605-620
Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Yu, Zhiling; Liang, Chun

Identification of Molecular Biomarkers for the Diagnosis of Gastric Cancer and Lymph-node Metastasis

Gastroenterology Report, v. 7, (1), February 2019, p. 57-66
Seeruttun, Sharvesh Raj; Cheung, Wing Yan; Wang, Wei; Fang, Cheng; Liu, Zhimin; Li, Jinqing; Wu, Ting; Wang, Jun; Liang, Chun; Zhou, Zhiwei

Reproductive Systemic Toxicity and Mechanism of Glucosides of Tripterygium wilfordii Hook. F. (GTW)

Annals of Clinical and Laboratory Science, v. 49, (1), January 2019, p. 36-49
Guo, Jianmin; Huang, Yuankeng; Lei, Xialing; Zhang, Hong; Xiao, Baiquan; Han, Zhong; Liang, Chun; Yang, Wei

The Interaction Networks of the Budding Yeast and Human DNA Replication-initiation Proteins

Cell Cycle, v. 18, (6-7), April 2019, p. 723-741
Wu, Rentian; Amin, Aftab; Wang, Ziyi; Huang, Yining; Cheung, Man Hei; Yu, Zhiling; Yang, Wei; Liang, Chun

Article 4

Biomarkers associated with binaprofen‑induced liver injury

Molecular Medicine Reports, v.18, (6), December 2018, p. 5076-5086
Guo, Qiuping; Guo, Jianmin; Chen, Guiying; Han, Zhong; Xiao, Baiquan; Jin, Ruomin; Liang, Chun; Yang, Wei

Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway

Evidence-based Complementary and Alternative Medicine, v. 2018, 2018, article number 6356190, p. 1-12
Wu, Hai-wang; Feng, Yi-hui; Wang, Dong-ying; Qiu, Wei-yu; Yu, Qing-ying; Yang, Li-lin; Liang, Chun; Luo, Song-ping; Gao, Jie

Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways

Scientific Reports, v. 8, (1), November 2018, article number 17342
Gao, Feixia; Zhou, Chun; Qiu, Weiyu; Wu, Haiwang; Li, Jing; Peng, Jinting; Qiu, Min; Liang, Chun; Gao, Jie; Luo, Songping

雷公藤多苷对雄性SD大鼠生殖系统损伤的动态变化及其可能机制

中国药理学与毒理学杂志=Chinese Journal of Pharmacology and Toxicology, v. 32, (6), June 2018, p. 469-476
郭健敏; 黄远铿; 雷夏凌; 韩重; 梁純; 杨威

Conference paper 2

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle regulates eukaryotic chromosomal DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Liang, Chun

Rrp12 Functions as a Novel DNA Replication Initiation Protein

Yu, Zhiling; Amin, Aftab; Liang, Chun

Article 1

Mitoxantrone Suppresses Vascular Smooth Muscle Cell (VSMC) Proliferation and Balloon Injury-induced Neointima Formation: An in Vitro and in Vivo Study

Bosnian Journal of Basic Medical Sciences, v. 17, (4), November 2017, p. 339-348
Teng, Yuan; Wang, Ziyi; Li, Wen; Yu, Jianxing; Shan, Zhen; Liang, Chun; Wang, Shenming

Conference paper 3

A Role of NOC3 in DNA Replication Initiation in Human Cells

Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Zhong, Shan; Liang, Chun

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Zhou, Zijing; Wang, Ziyi; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun

An essential, cell cycle-dependent and semi-conservative ORC dimerization cycle critically regulates DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun

Article 3

A Role of hIPI3 in DNA Replication Licensing in Human Cells

PLoS ONE, v. 11, (4), April 2016, article number e0151803
Huang, Yining; Amin, Aftab; Qin, Yan; Wang, Ziyi; Jiang, Huadong; Liang, Lu; Shi, Linjing; Liang, Chun

Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics

Fitoterapia, v. 112, July 2016, p. 175-182
Yu, Rujian; Liu, Haibin; Yu, Yang; Liang, Lu; Xu, Rui; Liang, Chun; Tang, Jinshan; Yao, Xinsheng

Asperosaponin VI Promotes Progesterone Receptor Expression in Decidual Cells via the Notch Signaling Pathway

Fitoterapia, v. 113, September 2016, p. 58-63
Gao, Jie; Zhou, Chun; Li, Yadi; Gao, Feixia; Wu, Haiwang; Yang, Lilin; Qiu, Weiyu; Zhu, Lin; Du, Xin; Lin, Weixian; Huang, Dandan; Liu, Haibin; Liang, Chun; Luo, Songping

Conference paper 2

Regulation of DNA replicaiton in normal and cancer cells and cancer metasatsis mechanisms

Liang, Chun

The Capillary Number Effect on the Capture Efficiency of Cancer Cells on Composite Microfluidic Filtration Chips

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), v. 2015-February, (February), February 2015, article number 7050989, p. 459-462
Zhao, Cong; Xu, Rui; Song, Kui; Liu, Dayu; Ma, Shou; Tang, Chen; Liang, Chun; Zohar, Yitshak; Lee, Yi-kuen

Article 2

Isolation of circulating tumor cells under hydrodynamic loading using microuidic technology

力学进展=Advances in Mechanics, v .44, (1), January 2014, p. 447-494
Zhao, Cong; Lee, Yi-Kuen; Xu, Rui; Liang, Chun; Liu, Dayu; Ma, Wei; Piyawattanmetha, Wibool; Zohar, Yitshak

MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer

Molecular Cancer Research, v. 12, (11), November 2014, p. 1535-1546
Zhang, Xin; Xiao, Dakai; Wang, Ziyi; Zou, Yongxin; Huang, Liyan; Lin, Weixuan; Deng, Qiuhua; Pan, Hui; Zhou, Jiangfen; Liang, Chun; He, Jianxing

Conference paper 1

Regulation of DNA Replication in Normal and Cancer Cells

Liang, Chun

Conference paper 3

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication

Wu, Rentian; Zhou, Zijing; Wang, Jiafeng; Amin, Aftab; Wang, Ziyi; Liang, Chun

Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Applications In Cancer

Liang, Chun

Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Clinical Applications

Liang, Chun

Article 3

Cdt1p, through its interaction with Mcm6P, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex

Journal of cell science, v. 125, (1), 2012, p. 209-219
Wu, Rentian; Wang, Jiafeng; Liang, Chun

Structural insights into the Cdt1-mediated MCM2-7 chromatin loading

Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang

The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis

Cell cycle, v. 11, (7), 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, TszChoi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun

Article 2

APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

PLoS ONE, v. 6, (10), October 2011, article number e24669
Geng, Hua; Law, Peggy P.Y.; Ng, Maggie C.Y.; Li, Ting; Liang, Li-Yun; Ge, Tian-Fang; Wong, Kam-Bo; Liang, Chun; Ma, Ronald C.; So, Wing-Yee; Chan, Juliana C.N.; Ho, Yuan-Yuan

Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast

FEMS yeast research, v. 11, (1), 2011, p. 72-79
Lai, Fenju; Wu, Rentian; Wang, Jiafeng; Li, Chunming; Zou, Lan; Lu, Yongjun; Liang, Chun

Book chapter 1

Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast

Fundamental Aspects of DNA Replication / Edited by Jelena Kušić-Tišma, Croati: InTech Publisher, Chapter 6, p. 87-106
Zhai, Yuanliang; Yung, Philip; Liang, Chun

Article 6

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast

Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Journal of cell science, v. 123, (22), 2010, p. 3933-3943
Zhai, Yuanliang; Yung, P.Y.K.; Huo, Lin; Liang, Chun

Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6

Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang

Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast

Biochemical and biophysical research communications, v. 395, (3), 2010, MAY 7, p. 336-341
Wang, Jiafeng; Wu, Rentian; Lu, Yongjun; Liang, Chun

Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae

Cell Cycle, v. 9, (21), 2010, Nov, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, TszChoi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun

The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells

Cell Cycle, v. 9, (24), 2010, p. 4848-4857
Zhang, Jing; Yu, Lan; Wu, Xing; Zou, Lan; Sou, K.K.L.; Wei, Zhun; Cheng, Xue; Zhu, Guang; Liang, Chun

Conference paper 4

A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome

James Watson Symposium on Cancer, Cold Spring Harbor Asia Conferences, Suzhou, China, April 2010
Kan, Junsuo; Wang, Ziyi; Tu, Zheng; Zhang, Jingjing; Wu, Xing; Liang, Chun

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun

Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast

Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun

Nuclear Matrix Association of Orc and Utp7P is Inter-Dependent, Cell Cycle-Regulated, and required for Pre-Replicative Complex Assembly in Budding Yeast

Cold Spring Harbor Lab 'The Cell Cycle' Meeting, Cold Spring Harbor Lab, N. Y., USA, 5/2010
Cheng, Xue; Wang, Jiafeng; Xu, Zhen; Liang, Chun

Article 1

Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma

Mutation research-fundamental and MOLECULAR MECHANISMS OF Mutagenesis, v. 662, (1-2), 2009, MAR 9, p. 10-15
Xiong, Xing-Dong; Qiu, Fu-En; Fang, Jian-Hong; Shen, Yi; Liang, Chun; Jiang, Wenqi; Zhuang, Shi-Mei

Conference paper 2

A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome

The Cold Spring Harbor Lab 'Eukaryotic DNA Replication & Genome Maintenance' Meeting, Cold Spring Harbor Lab, N.Y. USA, 09/2009
Kan, Junsuo; Wang, Ziyi; Tu, Zhen; Wu, Xing; Liang, Chun

Identification of the functional domains involved in the interaction between human Cdt1 and Mcm6

The Cold Spring Harbor Lab “Eukaryotic DNA Replication & Genome Maintenance” Meeting, Cold Spring Harbor Lab, N.Y., USA, 9/2009
Zhang, Jingjing; Wu, Xing; Yu, Lan; Wei, Zhun; Zou, Lan; Zhu, Guang; Liang, Chun

Article 3

Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80, and Itself

Journal of virology, v. 82, (24), 2008, DEC 15, p. 12356-12364
Wu, Wenbi; Liang, Hanquan; Kan, Junsuo; Liu, Chao; Yuan, Meijin; Liang, Chun; Yang, Kai; Pang, Yi

mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue

BMC cancer, v. 8, 2008, DEC 30
Li, Jian-na; Feng, Chong-jin; Lu, Yong-jun; Li, Hui-jun; Tu, Zheng; Liao, Guiqing; Liang, Chun

Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae

Journal of biological chemistry, v. 283, (49), 2008, DEC 5, p. 33803-33807
Kan, Junsuo; Zou, Lan; Zhang, Jingjing; Wu, Rentian; Wang, Ziyi; Liang, Chun

Conference paper 2

The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis

The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun

The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis

11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun

Article 1

Ecdysone induces transcription and amplification in Sciara coprophila DNA puff II/9A

Developmental Biology Biol, v. 299, (1), 2006, p. 151-163
Foulk, Michael S.; Liang, Chun; Wu, Nan; Blitzblau, Hannah G.; Smith, Heidi S.; Alam, Daniel; Batra, Maneesh; Gerbi, Susan A.

Conference paper 2

Ipi3p is an essential DNA replication-initiation protein required for and directly involved in pre-replication complex assembly and maintenance (Talk)

The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2006
Huo, Lin; Yu, Zhiling; Chan, Tsz Choi; Lu, Yongjun; Zhang, Yuan; Wong, Bonnie; Labib, Karim; Liang, Chun

RRP12 plays an essential and direct role in the initiation of DNA replication in budding yeast

The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 5.2006
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun

Conference paper 5

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun

Ipi3, a novel replication-initiation protein identified by the IDR (Initiation of DNA Replication) screen with td (temperature-sensitive degron) mutants.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Huo, Lin; Chan, Tsz Choi; Yu, Zhiling; Wong, Bonny Y.M.; Lu, Yongjun; Labib, Karim; Liang, Chun

Noc3p, Rrp12p and Ipi3p, a Group of Proteins Involved in Both the Initiation of DNA Replication and Ribosome Biogenesis. (Invited talk)

eIMBL Video Conference on DNA Replication, 11.2005
Liang, Chun

Rrp12 plays an essential and direct role in the initiation of DNA replication in budding yeast.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun

The human homolog of the yeast Noc3 is required for DNA replication in human cells.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zou, Sally Lan; Hu, Yun; Wu, Jingwen; Wu, Xing; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun

Article 1

Pairwise interactions of the six human MCM protein subunits

Journal of Molecular Biology, v. 340, (5), 2004, JUL 23, p. 1197-1206
Yu, Zhiling; Feng, Daorong; Liang, C.

Conference paper 3

Pairwise Interactions of the Six Human MCM Protein Subunits

The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Yu, Zhiling; Feng, Daorong; Liang, Chun

RT-PCR Detection of Bladder Carcinoma in Voided Urine Cells using DNA Replication-initiation proteins as the Markers

The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Tu, Zheng; Tong, Tommy Sw; Li, Kamming; Huo, Lin; Sou, Kelvin K.L.; Liang, Chun

Studies on the Human Homolog of the Yeast Noc3 in Human Cells

9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, Crete,Greece, 10.2004;
Zou, Lan; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun

Article 2

Cdc48p is required for the cell cycle commitment point at start via degradation of the G1-CDK inhibitor Far1p

Journal of Cell Biology, v. 163, (1), 2003, OCT 13, p. 21-26
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun

Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells

Cancer research, v. 63, (21), 2003, NOV 1, p. 7356-7364
Feng, Daorong; Tu, Zheng; Wu, Wenyan; Liang, Chun

Conference paper 2

A Novel Phenotypic screen for Dna replication-Initiations in Saccharomyces cerevisiae: the IDR (Initiation of DNA Replication) Screen

Chan, Tsz Choi; Lu, Yongjun; Fu, Xinrong; Leung, Ivy; Lu, Gan; Zhai, Yanliang; Yu, Zhiling; Liang, Chun

Cdc48p, an AAA-family protein, is required for both the initiation of DNA replication and cell cycle control at START in budding yeast

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab., USA, Sept
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun

Article 2

A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara

Chromosoma, v. 111, (5), 2002, p. 291-303
Urnov, Fyodor D.; Liang, Chun; Blitzblau, Hannah G.; Smith, Heidi S.; Gerbi, Susan A.

Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast

Cell, v. 109, (7), 2002, JUN 28, p. 849-860
Zhang, Yuexuan; Yu, Zhiling; Fu, Xinrong; Liang, Chun

Conference paper 2

DNA replication and cancer

5th Conference of the Asia-Pacific International Molecular Biology Network, Shanghai, China, p. 23
Liang, Chun

Identification and characterization of novel initiation proteins for DNA replication in budding yeast

FASEB Summer Research Conference on Yeast Chromosome Structure, Replication and Segregation, Snowmass, Colorado, USA.
Liang, Chun; Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry

Article 2

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle

Proceedings of the National Academy of Sciences of the United States of America, v. 98, (20), 2001, p. 11211-11217
Weinreich, Michael D.; Liang, Chun; Chen, Hsuhsin; Stillman, Bruce W.

DNA replication and cancer

Asia-med, 5: 61-65
Liang, Chun; Fu, Xinrong; Zhang, Yuexuan; Lu, Yongjun; Feng, Doarong; Li, Kamming; Yu, Zhiling; Sou, Kelvin

Book chapter 1

Initiation proteins for DNA replication in normal and cancer cells

Molecular Genetic Basis of Cancer / Edited by M.L. Lung and W.L.W. Hsiao., published by HKUST, p. 316-324
Liang, Chun

Conference paper 1

Identification and characterization of previously unknown replication initiation proteins in S. cerevisiae

Eukaryotic DNA Replication, Cold Spring Harbor Laboratory, New York, USA
Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry; Liang, Chun

Article 1

The Cdc6p nucleotide binding motif is required for loading Mcm proteins onto chromatin

Proceedings of the National Academy of Sciences of the United States of America, v. 96, (2), Jan, 1999, p. 441-446
Weinreich, Michael D.; Liang, Chun; Stillman, Bruce W.

Book chapter 1

Methods to map origins of replication in eukaryotes

Eukaryotic DNA Replication: A Practical Approach / Edied by S. Cotterill., Oxford University Press, Chapter 1, 1999, p. 1-42.
Gerbi, S.A.; Bielinsky, A.; Liang, Chun; Lunyak, V.; Urnov, F.

Article 1

Persistent initiation of DNA replication and chromatin bound MCM proteins during the cell cycle in cdc6 mutants

Genes and Development, v. 11, (24), 1997, p. 3375-3386
Liang, Chun; Stillman, Bruce W.

Article 1

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

Cell, v. 81, 1995, p. 667-676
Liang, Chun; Weinreich, Michael D.; Stillman, Bruce W.

Article 1

Analysis of an origin of DNA amplification in Sciara coprophila using a novel three-dimensional gel method

Molecular and Cellular Biology, v. 14, (2), 1994, p. 1520-1529
Liang, Chun; Gerbi, Susan A.

Article 3

Developmental progression in Sciara coprophila DNA puffs: DNA amplification and transcription

Developmental Biology, v. 160, (1), November 1993, p. 73-84
Wu, Nan; Liang, Chun; Smith, Heidi S.; Dibartolomeis, Susan M.; Gerbi, Susan A.

DNA amplification in DNA puff II/9A of Sciara coprophila.

Cold Spring Harbor Symposia on Quantitative Biology, v. 58, 1993, p. 487-494
Gerbi, Susan A.; Liang, Chun; Wu, Nan; DiBartolomeis, Susan M.; Bienz-Tadmor, Brigitte; Smith, Heidi S.; Urnov, Fyodor D.

Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A

Genes and Development, v. 7, (6), 1993, p. 1072-1084
Liang, Chun; Spitzer, Josephine D.; Smith, Heidi S.; Gerbi, Susan A.

2018 6

Biomarkers associated with binaprofen‑induced liver injury

Molecular Medicine Reports, v.18, (6), December 2018, p. 5076-5086
Guo, Qiuping; Guo, Jianmin; Chen, Guiying; Han, Zhong; Xiao, Baiquan; Jin, Ruomin; Liang, Chun; Yang, Wei
Article

Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway

Evidence-based Complementary and Alternative Medicine, v. 2018, 2018, article number 6356190, p. 1-12
Wu, Hai-wang; Feng, Yi-hui; Wang, Dong-ying; Qiu, Wei-yu; Yu, Qing-ying; Yang, Li-lin; Liang, Chun; Luo, Song-ping; Gao, Jie
Article

Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways

Scientific Reports, v. 8, (1), November 2018, article number 17342
Gao, Feixia; Zhou, Chun; Qiu, Weiyu; Wu, Haiwang; Li, Jing; Peng, Jinting; Qiu, Min; Liang, Chun; Gao, Jie; Luo, Songping
Article

雷公藤多苷对雄性SD大鼠生殖系统损伤的动态变化及其可能机制

中国药理学与毒理学杂志=Chinese Journal of Pharmacology and Toxicology, v. 32, (6), June 2018, p. 469-476
郭健敏; 黄远铿; 雷夏凌; 韩重; 梁純; 杨威
Article

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle regulates eukaryotic chromosomal DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Liang, Chun
Conference paper

Rrp12 Functions as a Novel DNA Replication Initiation Protein

Yu, Zhiling; Amin, Aftab; Liang, Chun
Conference paper

2017 4

Mitoxantrone Suppresses Vascular Smooth Muscle Cell (VSMC) Proliferation and Balloon Injury-induced Neointima Formation: An in Vitro and in Vivo Study

Bosnian Journal of Basic Medical Sciences, v. 17, (4), November 2017, p. 339-348
Teng, Yuan; Wang, Ziyi; Li, Wen; Yu, Jianxing; Shan, Zhen; Liang, Chun; Wang, Shenming
Article

A Role of NOC3 in DNA Replication Initiation in Human Cells

Cheung, Man Hei; Amin, Aftab; Wu, Rentian; Qin, Yan; Zou, Lan; Zhong, Shan; Liang, Chun
Conference paper

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Zhou, Zijing; Wang, Ziyi; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun
Conference paper

An essential, cell cycle-dependent and semi-conservative ORC dimerization cycle critically regulates DNA replication

Amin, Aftab; Wu, Rentian; Cheung, Man Hei; Scott, John Francis; Wang, Ziyi; Zhou, Zijing; Zhang, Chuchu; Wang, Jiafeng; Liang, Chun
Conference paper

2016 3

A Role of hIPI3 in DNA Replication Licensing in Human Cells

PLoS ONE, v. 11, (4), April 2016, article number e0151803
Huang, Yining; Amin, Aftab; Qin, Yan; Wang, Ziyi; Jiang, Huadong; Liang, Lu; Shi, Linjing; Liang, Chun
Article

Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics

Fitoterapia, v. 112, July 2016, p. 175-182
Yu, Rujian; Liu, Haibin; Yu, Yang; Liang, Lu; Xu, Rui; Liang, Chun; Tang, Jinshan; Yao, Xinsheng
Article

Asperosaponin VI Promotes Progesterone Receptor Expression in Decidual Cells via the Notch Signaling Pathway

Fitoterapia, v. 113, September 2016, p. 58-63
Gao, Jie; Zhou, Chun; Li, Yadi; Gao, Feixia; Wu, Haiwang; Yang, Lilin; Qiu, Weiyu; Zhu, Lin; Du, Xin; Lin, Weixian; Huang, Dandan; Liu, Haibin; Liang, Chun; Luo, Songping
Article

2015 2

Regulation of DNA replicaiton in normal and cancer cells and cancer metasatsis mechanisms

Liang, Chun
Conference paper

The Capillary Number Effect on the Capture Efficiency of Cancer Cells on Composite Microfluidic Filtration Chips

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), v. 2015-February, (February), February 2015, article number 7050989, p. 459-462
Zhao, Cong; Xu, Rui; Song, Kui; Liu, Dayu; Ma, Shou; Tang, Chen; Liang, Chun; Zohar, Yitshak; Lee, Yi-kuen
Conference paper

2014 3

Isolation of circulating tumor cells under hydrodynamic loading using microuidic technology

力学进展=Advances in Mechanics, v .44, (1), January 2014, p. 447-494
Zhao, Cong; Lee, Yi-Kuen; Xu, Rui; Liang, Chun; Liu, Dayu; Ma, Wei; Piyawattanmetha, Wibool; Zohar, Yitshak
Article

MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer

Molecular Cancer Research, v. 12, (11), November 2014, p. 1535-1546
Zhang, Xin; Xiao, Dakai; Wang, Ziyi; Zou, Yongxin; Huang, Liyan; Lin, Weixuan; Deng, Qiuhua; Pan, Hui; Zhou, Jiangfen; Liang, Chun; He, Jianxing
Article

Regulation of DNA Replication in Normal and Cancer Cells

Liang, Chun
Conference paper

2013 3

An essential, cell cycle-dependent and semiconservative ORC dimerization cycle critically regulates DNA replication

Wu, Rentian; Zhou, Zijing; Wang, Jiafeng; Amin, Aftab; Wang, Ziyi; Liang, Chun
Conference paper

Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Applications In Cancer

Liang, Chun
Conference paper

Regulation of DNA Replication in Normal and Cancer Cells: Basic Research and Potential Clinical Applications

Liang, Chun
Conference paper

2012 3

Cdt1p, through its interaction with Mcm6P, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex

Journal of cell science, v. 125, (1), 2012, p. 209-219
Wu, Rentian; Wang, Jiafeng; Liang, Chun
Article

Structural insights into the Cdt1-mediated MCM2-7 chromatin loading

Nucleic Acids Research, v. 40, (7), April 2012, p. 3208-3217
Liu, Changdong; Wu, Rentian; Zhou, Bo; Wang, Jiafeng; Wei, Zhun; Tye, Bik Kwoon; Liang, Chun; Zhu, Guang
Article

The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis

Cell cycle, v. 11, (7), 2012, p. 1325-1339
Huo, Lin; Wu, Rentian; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, TszChoi; Yeung, Jeffrey T.F.; Kan, Junsuo; Liang, Chun
Article

2011 3

APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

PLoS ONE, v. 6, (10), October 2011, article number e24669
Geng, Hua; Law, Peggy P.Y.; Ng, Maggie C.Y.; Li, Ting; Liang, Li-Yun; Ge, Tian-Fang; Wong, Kam-Bo; Liang, Chun; Ma, Ronald C.; So, Wing-Yee; Chan, Juliana C.N.; Ho, Yuan-Yuan
Article

Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast

FEMS yeast research, v. 11, (1), 2011, p. 72-79
Lai, Fenju; Wu, Rentian; Wang, Jiafeng; Li, Chunming; Zou, Lan; Lu, Yongjun; Liang, Chun
Article

Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast

Fundamental Aspects of DNA Replication / Edited by Jelena Kušić-Tišma, Croati: InTech Publisher, Chapter 6, p. 87-106
Zhai, Yuanliang; Yung, Philip; Liang, Chun
Book chapter

2010 10

ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast

Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 29974-29980
Cheng, Xue; Xu, Zhen; Wang, Jiafeng; Zhai, Yuanliang; Lu, Yongjun; Liang, Chun
Article

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Journal of cell science, v. 123, (22), 2010, p. 3933-3943
Zhai, Yuanliang; Yung, P.Y.K.; Huo, Lin; Liang, Chun
Article

Characterization and structure determination of the cdt1 binding domain of human minichromosome maintenance (Mcm) 6

Journal of Biological Chemistry, v. 285, (17), April 2010, p. 12469-12473
Wei, Zhun; Liu, Changdong; Wu, Xing; Xu, Naining; Zhou, Bo; Liang, Chun; Zhu, Guang
Article

Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast

Biochemical and biophysical research communications, v. 395, (3), 2010, MAY 7, p. 336-341
Wang, Jiafeng; Wu, Rentian; Lu, Yongjun; Liang, Chun
Article

Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Genome-wide Phenotypic Screen in Saccharomyces Cerevisiae

Cell Cycle, v. 9, (21), 2010, Nov, p. 4399-4410
Ma, Lijuan; Zhai, Yuanliang; Feng, Daorong; Chan, TszChoi; Lu, Yongjun; Fu, Xinrong; Wang, Jui-pin; Chen, Yanhong; Li, Jianna; Xu, Ke; Liang, Chun
Article

The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells

Cell Cycle, v. 9, (24), 2010, p. 4848-4857
Zhang, Jing; Yu, Lan; Wu, Xing; Zou, Lan; Sou, K.K.L.; Wei, Zhun; Cheng, Xue; Zhu, Guang; Liang, Chun
Article

A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome

James Watson Symposium on Cancer, Cold Spring Harbor Asia Conferences, Suzhou, China, April 2010
Kan, Junsuo; Wang, Ziyi; Tu, Zheng; Zhang, Jingjing; Wu, Xing; Liang, Chun
Conference paper

Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast

Cold Spring Harbor-Asia Symposium, Suzhou, China, Apr. 2010
Zhai, Yuanliang; Yung, Philip Y.K.; Huo, Lin; Liang, Chun
Conference paper

Interaction network of DNA replication-initiation proteins and dimerization of ORC and Noc3p in pre-replicative complex assembly in budding yeast

Cold Spring Harbor Lab 'The Cell Cycle'Meeting, Cold Spring Harbor Lab, N.Y., USA, 5/2010
Wu, Rentian; Zhang, Chuchu; Yeung, Yun Fai; Wang, Jiafeng; Huo, Lin; Zhai, Yuanliang; Liang, Chun
Conference paper

Nuclear Matrix Association of Orc and Utp7P is Inter-Dependent, Cell Cycle-Regulated, and required for Pre-Replicative Complex Assembly in Budding Yeast

Cold Spring Harbor Lab 'The Cell Cycle' Meeting, Cold Spring Harbor Lab, N. Y., USA, 5/2010
Cheng, Xue; Wang, Jiafeng; Xu, Zhen; Liang, Chun
Conference paper

2009 3

Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma

Mutation research-fundamental and MOLECULAR MECHANISMS OF Mutagenesis, v. 662, (1-2), 2009, MAR 9, p. 10-15
Xiong, Xing-Dong; Qiu, Fu-En; Fang, Jian-Hong; Shen, Yi; Liang, Chun; Jiang, Wenqi; Zhuang, Shi-Mei
Article

A Group of General DNA Replication Origins and Replicators Sharing Homologous Sequences and Dispersed throughout the Human Genome

The Cold Spring Harbor Lab 'Eukaryotic DNA Replication & Genome Maintenance' Meeting, Cold Spring Harbor Lab, N.Y. USA, 09/2009
Kan, Junsuo; Wang, Ziyi; Tu, Zhen; Wu, Xing; Liang, Chun
Conference paper

Identification of the functional domains involved in the interaction between human Cdt1 and Mcm6

The Cold Spring Harbor Lab “Eukaryotic DNA Replication & Genome Maintenance” Meeting, Cold Spring Harbor Lab, N.Y., USA, 9/2009
Zhang, Jingjing; Wu, Xing; Yu, Lan; Wei, Zhun; Zou, Lan; Zhu, Guang; Liang, Chun
Conference paper

2008 5

Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80, and Itself

Journal of virology, v. 82, (24), 2008, DEC 15, p. 12356-12364
Wu, Wenbi; Liang, Hanquan; Kan, Junsuo; Liu, Chao; Yuan, Meijin; Liang, Chun; Yang, Kai; Pang, Yi
Article

mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue

BMC cancer, v. 8, 2008, DEC 30
Li, Jian-na; Feng, Chong-jin; Lu, Yong-jun; Li, Hui-jun; Tu, Zheng; Liao, Guiqing; Liang, Chun
Article

Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae

Journal of biological chemistry, v. 283, (49), 2008, DEC 5, p. 33803-33807
Kan, Junsuo; Zou, Lan; Zhang, Jingjing; Wu, Rentian; Wang, Ziyi; Liang, Chun
Article

The Ipi1p/2p/3p Complex Is Required for and Directly Involved in Pre-Replication Complex Formation Independent of Ribosome Biogenesis

The 9th AEARU Workshop on Molecular Biology and Biotechnology, HKUST, Hong Kong, March 25-26, 2008
Huo, Lin; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Chan, Tsz Choi; Lu, Yongjun; Wu, Rentian; Zhang, Yuan; Wong, Bonny Y.M.; Sou, Kelvin K.L.; Liang, Chun
Conference paper

The Rix1 (Ipi1p/2p/3p) Complex Is a Critical Determinant of Replication Licensing Independent of Ribosome Biogenesis

11th Annual Conference of A-Imbn Fellows & 9th International Congress on Cell Biology, Seoul, Korea; October , 2008
Lin, Huo; Yu, Zhiling; Zhai, Yuanliang; Yang, Xiaoxia; Lu, Yongjun; Wu, Rentian; Chan, Tsz-Choi; Liang, Chun
Conference paper

2006 3

Ecdysone induces transcription and amplification in Sciara coprophila DNA puff II/9A

Developmental Biology Biol, v. 299, (1), 2006, p. 151-163
Foulk, Michael S.; Liang, Chun; Wu, Nan; Blitzblau, Hannah G.; Smith, Heidi S.; Alam, Daniel; Batra, Maneesh; Gerbi, Susan A.
Article

Ipi3p is an essential DNA replication-initiation protein required for and directly involved in pre-replication complex assembly and maintenance (Talk)

The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2006
Huo, Lin; Yu, Zhiling; Chan, Tsz Choi; Lu, Yongjun; Zhang, Yuan; Wong, Bonnie; Labib, Karim; Liang, Chun
Conference paper

RRP12 plays an essential and direct role in the initiation of DNA replication in budding yeast

The Cell Cycle Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 5.2006
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun
Conference paper

2005 5

Identification of novel initiation proteins for yeast DNA replication by using the IDR (Initiation of DNA Replication) screen

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zhai, Yuanliang; Chan, Tsz Choi; Feng, Daorong; Fu, Xinrong; Lo, Alice; Chen, Yanhong; Ma, Lijuan; Lu, Yongjun; Liang, Chun
Conference paper

Ipi3, a novel replication-initiation protein identified by the IDR (Initiation of DNA Replication) screen with td (temperature-sensitive degron) mutants.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Huo, Lin; Chan, Tsz Choi; Yu, Zhiling; Wong, Bonny Y.M.; Lu, Yongjun; Labib, Karim; Liang, Chun
Conference paper

Noc3p, Rrp12p and Ipi3p, a Group of Proteins Involved in Both the Initiation of DNA Replication and Ribosome Biogenesis. (Invited talk)

eIMBL Video Conference on DNA Replication, 11.2005
Liang, Chun
Conference paper

Rrp12 plays an essential and direct role in the initiation of DNA replication in budding yeast.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Yu, Zhiling; Chan, Tsz Choi; Huo, Lin; Zou, Sally Lan; Lu, Yongjun; Xu, Anlong; Labib, Karim; Liang, Chun
Conference paper

The human homolog of the yeast Noc3 is required for DNA replication in human cells.

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Laboratory, N.Y., USA, 9.2005
Zou, Sally Lan; Hu, Yun; Wu, Jingwen; Wu, Xing; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun
Conference paper

2004 4

Pairwise interactions of the six human MCM protein subunits

Journal of Molecular Biology, v. 340, (5), 2004, JUL 23, p. 1197-1206
Yu, Zhiling; Feng, Daorong; Liang, C.
Article

Pairwise Interactions of the Six Human MCM Protein Subunits

The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Yu, Zhiling; Feng, Daorong; Liang, Chun
Conference paper

RT-PCR Detection of Bladder Carcinoma in Voided Urine Cells using DNA Replication-initiation proteins as the Markers

The Cell Cycle Meeting, Cold Spring Harbor Lab., USA, May
Tu, Zheng; Tong, Tommy Sw; Li, Kamming; Huo, Lin; Sou, Kelvin K.L.; Liang, Chun
Conference paper

Studies on the Human Homolog of the Yeast Noc3 in Human Cells

9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, Crete,Greece, 10.2004;
Zou, Lan; Zhong, Shan; Zhang, Wei; Lee, Tracy; Xu, Anlong; Liang, Chun
Conference paper

2003 4

Cdc48p is required for the cell cycle commitment point at start via degradation of the G1-CDK inhibitor Far1p

Journal of Cell Biology, v. 163, (1), 2003, OCT 13, p. 21-26
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun
Article

Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells

Cancer research, v. 63, (21), 2003, NOV 1, p. 7356-7364
Feng, Daorong; Tu, Zheng; Wu, Wenyan; Liang, Chun
Article

A Novel Phenotypic screen for Dna replication-Initiations in Saccharomyces cerevisiae: the IDR (Initiation of DNA Replication) Screen

Chan, Tsz Choi; Lu, Yongjun; Fu, Xinrong; Leung, Ivy; Lu, Gan; Zhai, Yanliang; Yu, Zhiling; Liang, Chun
Conference paper

Cdc48p, an AAA-family protein, is required for both the initiation of DNA replication and cell cycle control at START in budding yeast

Eukaryotic DNA Replication Meeting, Cold Spring Harbor Lab., USA, Sept
Fu, Xinrong; Ng, Christine; Feng, Daorong; Liang, Chun
Conference paper

2002 4

A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara

Chromosoma, v. 111, (5), 2002, p. 291-303
Urnov, Fyodor D.; Liang, Chun; Blitzblau, Hannah G.; Smith, Heidi S.; Gerbi, Susan A.
Article

Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast

Cell, v. 109, (7), 2002, JUN 28, p. 849-860
Zhang, Yuexuan; Yu, Zhiling; Fu, Xinrong; Liang, Chun
Article

DNA replication and cancer

5th Conference of the Asia-Pacific International Molecular Biology Network, Shanghai, China, p. 23
Liang, Chun
Conference paper

Identification and characterization of novel initiation proteins for DNA replication in budding yeast

FASEB Summer Research Conference on Yeast Chromosome Structure, Replication and Segregation, Snowmass, Colorado, USA.
Liang, Chun; Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry
Conference paper

2001 4

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle

Proceedings of the National Academy of Sciences of the United States of America, v. 98, (20), 2001, p. 11211-11217
Weinreich, Michael D.; Liang, Chun; Chen, Hsuhsin; Stillman, Bruce W.
Article

DNA replication and cancer

Asia-med, 5: 61-65
Liang, Chun; Fu, Xinrong; Zhang, Yuexuan; Lu, Yongjun; Feng, Doarong; Li, Kamming; Yu, Zhiling; Sou, Kelvin
Article

Initiation proteins for DNA replication in normal and cancer cells

Molecular Genetic Basis of Cancer / Edited by M.L. Lung and W.L.W. Hsiao., published by HKUST, p. 316-324
Liang, Chun
Book chapter

Identification and characterization of previously unknown replication initiation proteins in S. cerevisiae

Eukaryotic DNA Replication, Cold Spring Harbor Laboratory, New York, USA
Zhang, Yuexuan; Fu, Xinrong; Lu, Yongjun; Xu, Ke; Tsang, Henry; Liang, Chun
Conference paper

1999 2

The Cdc6p nucleotide binding motif is required for loading Mcm proteins onto chromatin

Proceedings of the National Academy of Sciences of the United States of America, v. 96, (2), Jan, 1999, p. 441-446
Weinreich, Michael D.; Liang, Chun; Stillman, Bruce W.
Article

Methods to map origins of replication in eukaryotes

Eukaryotic DNA Replication: A Practical Approach / Edied by S. Cotterill., Oxford University Press, Chapter 1, 1999, p. 1-42.
Gerbi, S.A.; Bielinsky, A.; Liang, Chun; Lunyak, V.; Urnov, F.
Book chapter

1997 1

Persistent initiation of DNA replication and chromatin bound MCM proteins during the cell cycle in cdc6 mutants

Genes and Development, v. 11, (24), 1997, p. 3375-3386
Liang, Chun; Stillman, Bruce W.
Article

1995 1

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

Cell, v. 81, 1995, p. 667-676
Liang, Chun; Weinreich, Michael D.; Stillman, Bruce W.
Article

1994 1

Analysis of an origin of DNA amplification in Sciara coprophila using a novel three-dimensional gel method

Molecular and Cellular Biology, v. 14, (2), 1994, p. 1520-1529
Liang, Chun; Gerbi, Susan A.
Article

1993 3

Developmental progression in Sciara coprophila DNA puffs: DNA amplification and transcription

Developmental Biology, v. 160, (1), November 1993, p. 73-84
Wu, Nan; Liang, Chun; Smith, Heidi S.; Dibartolomeis, Susan M.; Gerbi, Susan A.
Article

DNA amplification in DNA puff II/9A of Sciara coprophila.

Cold Spring Harbor Symposia on Quantitative Biology, v. 58, 1993, p. 487-494
Gerbi, Susan A.; Liang, Chun; Wu, Nan; DiBartolomeis, Susan M.; Bienz-Tadmor, Brigitte; Smith, Heidi S.; Urnov, Fyodor D.
Article

Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A

Genes and Development, v. 7, (6), 1993, p. 1072-1084
Liang, Chun; Spitzer, Josephine D.; Smith, Heidi S.; Gerbi, Susan A.
Article

No Publications

Teaching Assignment

2024-25 Fall 5 2023-24 Summer 2 2023-24 Spring 7 2023-24 Winter 0 2023-24 Fall 12 2022-23 Summer 2

LIFS1902	General Biology II
LIFS2210	Biochemistry I
LIFS3010	Molecular and Cellular Biology I
UROP1100N	Undergraduate Research Opportunities Series 1
UROP2100N	Undergraduate Research Opportunities Series 2

UROP1000	Undergraduate Research Opportunities
UROP1100M	Undergraduate Research Opportunities Series 1

LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4980	Biological Science Project Research II
LIFS4981	Biochemistry and Cell Biology Project Research II
LIFS6116G	Current Topics in Genomics and Bioinformatics
SCIE2500	Guided Study on Research II
UROP1100L	Undergraduate Research Opportunities Series 1
UROP4100L	Undergraduate Research Opportunities Series 4

LIFS1902	General Biology II
LIFS2210	Biochemistry I
LIFS3010	Molecular and Cellular Biology I
LIFS4960	Biological Science Capstone Project
LIFS4961	Biochemistry and Cell Biology Capstone Project
LIFS4963	Biotechnology Capstone Project
LIFS4970	Biological Science Project Research I
LIFS4971	Biochemistry and Cell Biology Project Research I
UROP1100K	Undergraduate Research Opportunities Series 1
UROP2100K	Undergraduate Research Opportunities Series 2
UROP3100K	Undergraduate Research Opportunities Series 3
UROP3200	Undergraduate Research Opportunities with Mini-conference Experience

UROP1000	Undergraduate Research Opportunities
UROP2100J	Undergraduate Research Opportunities Series 2

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

WANG, Xinran
Life Science
WANG, Ye
Life Science

Master of Philosophy

TAO, Yicheng
Life Science
WEI, Yanru
Life Science

Graduated RPGs

Doctor of Philosophy

GUO, Jianmin
Life Science( Completed in 2024 )
LIANG, Yanting
Life Science( Completed in 2023 )
KHAN, Muhammad Ajmal
Life Science( Completed in 2022 )

Master of Philosophy

CHEN, Canxi
Life Science( Completed in 2021 )

Projects

From January 2022 to December 2024

All Projects 4 Leading Projects 2 Participating Projects 2

Development of an inhaled liposomal drug based on the new anticancer targets DNA replication-initiation proteins

基于全新DNA復制起始蛋白抗癌靶標的脂質體吸入劑藥物開發 Leading

Department of Science and Technology of Guangdong Province
Project Team (HKUST)
LIANG Chun (Lead)
2022 -
The Roles, Mechanisms and Regulation of NOC3 Dimerization and ORC Dimerization in Yeast and Human Cells

NOC3二聚化和ORC二聚化在酵母和人類細胞中的功能、機制和調控 Leading

RGC - General Research Fund
Project Team (HKUST)
LIANG Chun (Lead)
2021 - 2024
Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction

國家人體組織功能重建工程技術研究中心香港分中心 Participating

Innovation and Technology Fund
Project Team (HKUST)
SUN Jianwei (Lead)

CHAU Ying

GUO Zhihong

HSING I-ming

IP Nancy Yuk-Yu

JIA Guocheng

KO Robert Kam Ming

KWOK Ryan Tsz Kin

LAM Wing Yip

LIANG Chun

LIN Nian

LUO Zhengtang

MI Yongli

TANG Benzhong

TSIM Karl Wah Keung

WILLIAMS Ian Duncan

WU Hongkai

WU Zhenguo

YAN Henry He

YAN Yan

YANG Jinglei

YAO Shuhuai
2015 -
State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)

分子神經科學國家重點實驗室（香港科技大學） Participating

Innovation and Technology Fund
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

CHOW King Lau

CHUNG Kenny K

GUO Zhihong

HUANG Pingbo

LIANG Chun

POON Randy Yat Choi

TSIM Karl Wah Keung

WONG Joseph Tin Yum

WONG Yung Hou

WU Zhenguo

ZHU Guang
2011 -