Faculty Profiles - ZHU Bonnie Danqing | The Hong Kong University of Science and Technology

Bonnie Danqing ZHU
朱丹青

PhD in Bioengineering
Stanford University, 2018

Assistant Professor
Department of Chemical and Biological Engineering
Division of Life Science

(852) 3469 2526
dqzhu@ust.hk
Room 4572A
Personal Web

Google Scholar

sIf2nGIAAAAJ

ORCID

0000-0003-3916-3192

ResearcherID

IUE-5573-2023

Scopus ID

57192214627

Research Interest Publications Projects Teaching Assignment RPG Supervision

Research Interest

Bioengineering
Computational medicine and health informatics
Protein engineering
Biomaterials

Publications

All Years 17 2025 2 2024 4 2023 2 2022 1 2021 3 2020 0 2019 5

2025 2

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma

Nature Cancer, v. 6, (5), May 2025, p. 838-853
Jing, Weiqiang; Zhu, Bonnie Danqing; Shi, Benkang; Jiang, Xinyi
Article

Engineering CAR-T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, January 2025, article number 2414882
Zhu, Bonnie Danqing; Kim, Won Joon; Lee, Hyunjin; Bao, Xiaoping; Kim, Pilnam
Article

2024 4

mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model

ACS Nano, v. 18, (3), January 2024, p. 2261-2278
Tang, Chunwei; Zhu, Danqing; Jiang, Xinyi
Article

Optimal trade-off control in machine learning–based library design, with application to adeno-associated virus (AAV) for gene therapy

Science Advances, v. 10, (4), January 2024, article number eadj3786
Zhu, Bonnie Danqing; Brookes, David H.; Busia, Akosua; Carneiro, Ana; Fannjiang, Clara; Popova, Galina; Lin, Li F.; Miller, Zachary M.; Williams, Evan R.; Chang, Edward F.; Nowakowski, Tomasz J.; Listgarten, Jennifer; Schaffer, David V.
Article

Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice

Science Advances, v. 10, (24), June 2024, article number eado4791
Wang, Yan; Zhang, Jing; Liu, Ying; Yue, Xiao; Han, Kun; Kong, Zhichao; Dong, Yuanmin; Yang, Zhenmei; Fu, Zhipeng; Tang, Chunwei; Shi, Chongdeng; Zhao, Xiaotian; Han, Maosen; Wang, Zhibin; Zhang, Yulin; Chen, Chen; Li, Anning; Sun, Peng; Zhu, Bonnie Danqing; Zhao, Kun; Jiang, Xinyi
Article

Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration

Advanced Materials, December 2024, article number 2409979
Zhao, Da‐wang; Zhang, Jing; Chen, Chen; Sun, Weiyi; Liu, Ying; Han, Maosen; Zhang, Yulin; Fu, Zhipeng; Shi, Chongdeng; Zhao, Xiaotian; Yang, Zhenmei; Tang, Chunwei; Zhao, Kun; Zhu, Bonnie Danqing; Zhang, Yuankai; Cheng, Lei; Jiang, Xinyi
Article

2023 2

Cell-Cell Interactions Enhance Cartilage Zonal Development in 3D Gradient Hydrogels

ACS Biomaterials Science and Engineering, v. 9, (2), February 2023, p. 831-843
Zhu, Danqing; Trinh, Pavin; Liu, Elisa; Yang, Fan
Article

Dual mRNA co-delivery for in situ generation of phagocytosis-enhanced CAR macrophages augments hepatocellular carcinoma immunotherapy

Journal of Controlled Release, v. 360, August 2023, p. 718-733
Yang, Zhenmei; Liu, Ying; Zhao, Kun; Jing, Weiqiang; Gao, Lin; Dong, Xianghui; Wang, Yan; Han, Maosen; Shi, Chongdeng; Tang, Chunwei; Sun, Peng; Zhang, Rui; Fu, Zhipeng; Zhang, Jing; Zhu, Danqing; Chen, Chen; Jiang, Xinyi
Article

2022 1

Optogenetic Application to Investigating Cell Behavior and Neurological Disease

Frontiers in Cellular Neuroscience, v. 16, February 2022, article number 811493
Zhu, Danqing; Johnson, Hunter J.; Chen, Jun; Schaffer, David V.
Article

2021 3

Adeno-associated virus vector for central nervous system gene therapy

Trends in Molecular Medicine, v. 27, (6), June 2021, p. 524-537
Zhu, Danqing; Schieferecke, Adam J.; Lopez, Paola A.; Schaffer, David V.
Article

Gradient Hydrogels for Optimizing Niche Cues to Enhance Cell-Based Cartilage Regeneration

Tissue Engineering, Part A, v. 27, (13-14), July 2021, p. 929-939
Liu, Elisa; Zhu, Danqing; Gonzalez DIaz, Eva; Tong, Xinming; Yang, Fan
Article

Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cellfates in 3D

Journal of Biomedical Materials Research - Part A, v. 109, (6), June 2021, p. 1027-1035
Zhu, Danqing; Trinh, Pavin; Li, Jianfeng; Grant, Gerry A.; Yang, Fan
Article

2018 2

Biochemical and Mechanical Gradients Synergize to Enhance Cartilage Zonal Organization in 3D

ACS Biomaterials Science and Engineering, v. 4, (10), October 2018, p. 3561-3569
Zhu, Danqing; Trinh, Pavin; Liu, Elisa; Yang, Fan
Article

Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-Scale Gradient Hydrogels as 3D Cell Niche

Tissue Engineering, Part A, v. 24, (1-2), January 2018, p. 1-10
Zhu, Danqing; Tong, Xinming; Trinh, Pavin; Yang, Fan
Article

2017 2

Covalently Adaptable Elastin-Like Protein–Hyaluronic Acid (ELP–HA) Hybrid Hydrogels with Secondary Thermoresponsive Crosslinking for Injectable Stem Cell Delivery

Advanced Functional Materials, v. 27, (28), July 2017, article number 1605609
Wang, Huiyuan; Zhu, Danqing; Paul, Alexandra; Cai, Lei; Enejder, Annika; Yang, Fan; Heilshorn, Sarah C.
Article

Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration

Biomaterials, v. 127, May 2017, p. 132-140
Zhu, Danqing; Wang, Huiyuan; Trinh, Pavin; Heilshorn, Sarah C.; Yang, Fan
Article

2016 1

Hydrogels with Dual Gradients of Mechanical and Biochemical Cues for Deciphering Cell-Niche Interactions

ACS Biomaterials Science and Engineering, v. 2, (5), May 2016, p. 845-852
Tong, Xinming; Jiang, James; Zhu, Danqing; Yang, Fan
Article

Article 2

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma

Nature Cancer, v. 6, (5), May 2025, p. 838-853
Jing, Weiqiang; Zhu, Bonnie Danqing; Shi, Benkang; Jiang, Xinyi

Engineering CAR-T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, January 2025, article number 2414882
Zhu, Bonnie Danqing; Kim, Won Joon; Lee, Hyunjin; Bao, Xiaoping; Kim, Pilnam

Article 4

mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model

ACS Nano, v. 18, (3), January 2024, p. 2261-2278
Tang, Chunwei; Zhu, Danqing; Jiang, Xinyi

Optimal trade-off control in machine learning–based library design, with application to adeno-associated virus (AAV) for gene therapy

Science Advances, v. 10, (4), January 2024, article number eadj3786
Zhu, Bonnie Danqing; Brookes, David H.; Busia, Akosua; Carneiro, Ana; Fannjiang, Clara; Popova, Galina; Lin, Li F.; Miller, Zachary M.; Williams, Evan R.; Chang, Edward F.; Nowakowski, Tomasz J.; Listgarten, Jennifer; Schaffer, David V.

Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice

Science Advances, v. 10, (24), June 2024, article number eado4791
Wang, Yan; Zhang, Jing; Liu, Ying; Yue, Xiao; Han, Kun; Kong, Zhichao; Dong, Yuanmin; Yang, Zhenmei; Fu, Zhipeng; Tang, Chunwei; Shi, Chongdeng; Zhao, Xiaotian; Han, Maosen; Wang, Zhibin; Zhang, Yulin; Chen, Chen; Li, Anning; Sun, Peng; Zhu, Bonnie Danqing; Zhao, Kun; Jiang, Xinyi

Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration

Advanced Materials, December 2024, article number 2409979
Zhao, Da‐wang; Zhang, Jing; Chen, Chen; Sun, Weiyi; Liu, Ying; Han, Maosen; Zhang, Yulin; Fu, Zhipeng; Shi, Chongdeng; Zhao, Xiaotian; Yang, Zhenmei; Tang, Chunwei; Zhao, Kun; Zhu, Bonnie Danqing; Zhang, Yuankai; Cheng, Lei; Jiang, Xinyi

Article 2

Cell-Cell Interactions Enhance Cartilage Zonal Development in 3D Gradient Hydrogels

ACS Biomaterials Science and Engineering, v. 9, (2), February 2023, p. 831-843
Zhu, Danqing; Trinh, Pavin; Liu, Elisa; Yang, Fan

Dual mRNA co-delivery for in situ generation of phagocytosis-enhanced CAR macrophages augments hepatocellular carcinoma immunotherapy

Journal of Controlled Release, v. 360, August 2023, p. 718-733
Yang, Zhenmei; Liu, Ying; Zhao, Kun; Jing, Weiqiang; Gao, Lin; Dong, Xianghui; Wang, Yan; Han, Maosen; Shi, Chongdeng; Tang, Chunwei; Sun, Peng; Zhang, Rui; Fu, Zhipeng; Zhang, Jing; Zhu, Danqing; Chen, Chen; Jiang, Xinyi

Article 1

Optogenetic Application to Investigating Cell Behavior and Neurological Disease

Frontiers in Cellular Neuroscience, v. 16, February 2022, article number 811493
Zhu, Danqing; Johnson, Hunter J.; Chen, Jun; Schaffer, David V.

Article 3

Adeno-associated virus vector for central nervous system gene therapy

Trends in Molecular Medicine, v. 27, (6), June 2021, p. 524-537
Zhu, Danqing; Schieferecke, Adam J.; Lopez, Paola A.; Schaffer, David V.

Gradient Hydrogels for Optimizing Niche Cues to Enhance Cell-Based Cartilage Regeneration

Tissue Engineering, Part A, v. 27, (13-14), July 2021, p. 929-939
Liu, Elisa; Zhu, Danqing; Gonzalez DIaz, Eva; Tong, Xinming; Yang, Fan

Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cellfates in 3D

Journal of Biomedical Materials Research - Part A, v. 109, (6), June 2021, p. 1027-1035
Zhu, Danqing; Trinh, Pavin; Li, Jianfeng; Grant, Gerry A.; Yang, Fan

Article 2

Biochemical and Mechanical Gradients Synergize to Enhance Cartilage Zonal Organization in 3D

ACS Biomaterials Science and Engineering, v. 4, (10), October 2018, p. 3561-3569
Zhu, Danqing; Trinh, Pavin; Liu, Elisa; Yang, Fan

Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-Scale Gradient Hydrogels as 3D Cell Niche

Tissue Engineering, Part A, v. 24, (1-2), January 2018, p. 1-10
Zhu, Danqing; Tong, Xinming; Trinh, Pavin; Yang, Fan

Article 2

Covalently Adaptable Elastin-Like Protein–Hyaluronic Acid (ELP–HA) Hybrid Hydrogels with Secondary Thermoresponsive Crosslinking for Injectable Stem Cell Delivery

Advanced Functional Materials, v. 27, (28), July 2017, article number 1605609
Wang, Huiyuan; Zhu, Danqing; Paul, Alexandra; Cai, Lei; Enejder, Annika; Yang, Fan; Heilshorn, Sarah C.

Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration

Biomaterials, v. 127, May 2017, p. 132-140
Zhu, Danqing; Wang, Huiyuan; Trinh, Pavin; Heilshorn, Sarah C.; Yang, Fan

Article 1

Hydrogels with Dual Gradients of Mechanical and Biochemical Cues for Deciphering Cell-Niche Interactions

ACS Biomaterials Science and Engineering, v. 2, (5), May 2016, p. 845-852
Tong, Xinming; Jiang, James; Zhu, Danqing; Yang, Fan

2018 2

Biochemical and Mechanical Gradients Synergize to Enhance Cartilage Zonal Organization in 3D

ACS Biomaterials Science and Engineering, v. 4, (10), October 2018, p. 3561-3569
Zhu, Danqing; Trinh, Pavin; Liu, Elisa; Yang, Fan
Article

Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-Scale Gradient Hydrogels as 3D Cell Niche

Tissue Engineering, Part A, v. 24, (1-2), January 2018, p. 1-10
Zhu, Danqing; Tong, Xinming; Trinh, Pavin; Yang, Fan
Article

2017 2

Covalently Adaptable Elastin-Like Protein–Hyaluronic Acid (ELP–HA) Hybrid Hydrogels with Secondary Thermoresponsive Crosslinking for Injectable Stem Cell Delivery

Advanced Functional Materials, v. 27, (28), July 2017, article number 1605609
Wang, Huiyuan; Zhu, Danqing; Paul, Alexandra; Cai, Lei; Enejder, Annika; Yang, Fan; Heilshorn, Sarah C.
Article

Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration

Biomaterials, v. 127, May 2017, p. 132-140
Zhu, Danqing; Wang, Huiyuan; Trinh, Pavin; Heilshorn, Sarah C.; Yang, Fan
Article

2016 1

Hydrogels with Dual Gradients of Mechanical and Biochemical Cues for Deciphering Cell-Niche Interactions

ACS Biomaterials Science and Engineering, v. 2, (5), May 2016, p. 845-852
Tong, Xinming; Jiang, James; Zhu, Danqing; Yang, Fan
Article

No Publications

Teaching Assignment

2025-26 Fall 2 2024-25 Summer 0 2024-25 Spring 2 2024-25 Winter 0 2024-25 Fall 1 2023-24 Summer 0

BEHI5003	Molecular and Cellular Bioengineering
UROP1100Q	Undergraduate Research Opportunities Series 1

CENG2210	Chemical and Biological Engineering Thermodynamics
UROP1100O	Undergraduate Research Opportunities Series 1

BIEN6930E

Molecular and Cellular Bioengineering

No Teaching Assignments

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 27 October 2025)

All Supervisions Current RPGs Graduated RPGs

Current RPGs

Doctor of Philosophy

CAO, Zhenxiao
Computer Science and Engineering
YAP, Octavius Jessica
Bioengineering
SUN, Mingyi
Bioengineering

Master of Philosophy

ZHAO, Rui
Bioengineering
KIM, Won Joon
Bioengineering

Graduated RPGs

Master of Philosophy

YAP, Octavius Jessica
Chemical and Biomolecular Engineering( Completed in 2025 )

Projects

From January 2023 to December 2025

All Projects 2

No Projects.
Spatiotemporally engineering of macrophage for translational applications topic 2: Development of Advanced Gene-editing Strategies for Efficient Macrophage Reprogramming In vitro and In vivo

巨噬細胞時空可控工程化改造關鍵技術及轉化應用研究課題二: 開發智能巨噬細胞基因編輯技術，實現巨噬細胞的高效體外和體內編輯 Participating

Ministry of Science and Technology of the People's Republic of China
Project Team (HKUST)
ZHU Bonnie Danqing
2024 -
State Key Laboratory of Nervous System Disorders (SKLNSD)

神經系統疾病全國重點實驗室 Participating

Innovation and Technology Fund
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)

BU Guojun

CHEN Hao

CHEUNG Tom

FU Amy Kit Yu

HUANG Pingbo

LIU Kai

QU Jianan

TANG Benzhong

WANG Jiguang

WONG Yung Hou

WU Angela Ruohao

WU Zhenguo

YANG Can

ZHU Bonnie Danqing
2011 -

Research Interest

Publications

2025 2

2024 4

2023 2

2022 1

2021 3

2018 2

2017 2

2016 1

Article 2

Article 4

Article 2

Article 1

Article 3

Article 2

Article 2

Article 1

2018 2

2017 2

2016 1

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2022 to December 2025 (As of 27 October 2025)

Current RPGs

Graduated RPGs

Projects

From January 2023 to December 2025

Your browser is out of date!