Faculty Profiles - KUANG Becki Yi | The Hong Kong University of Science and Technology

2024 4

Multiplex miRNA reporting platform for real-time profiling of living cells

Cell Chemical Biology, v. 31, (1), January 2024, p. 150-162
Hu, Yaxin; Li, Cheuk Yin; Lu, Qiuyu; Kuang, Yi
Article

Self-feedback loop-containing synthetic mRNA switches for controlled microRNA sensing

Bioorganic Chemistry, v. 144, March 2024, article number 107081
Liang, Zhenghua; Tan, Kaixin; Li, Cheuk Yin; Kuang, Yi
Article

Transdermal microarrayed electroporation for enhanced cancer immunotherapy based on DNA vaccination

Proceedings of the National Academy of Sciences of the United States of America, v. 121, (25), June 2024, article number e2322264121, p. 1-12
Wang, Yuan; Qu, Jin; Xiong, Chuxiao; Chen, Bing; Xie, Kai; Wang, Mingxue; Liu, Zhen; Yue, Zhao; Liang, Zhenghua; Wang, Feng; Zhang, Tianlong; Zhu, Guangyu; Kuang, Becki Yi; Shi, Peng
Article

VPg-based bidirectional synthetic mRNA circuits enable orthogonal protein regulation for high-resolution cell separation

Chemical Communications, v. 60, (41), May 2024, p. 5345-5464
Liang, Zhenghua; Hu, Yaxin; Li, Cheuk Yin; Yau, Wai Laam; Tan, Kaixin; Kuang, Yi
Article

2023 3

Dual Input-Controlled Synthetic mRNA Circuit for Bidirectional Protein Expression Regulation

ACS Synthetic Biology, v. 12, (9), September 2023, p. 2516-2523
Tan, Kaixin; Hu, Yaxin; Liang, Zhenghua; Li, Cheuk Yin; Yau, Wai Laam; Kuang, Yi
Article

Heterogeneity of chemical modifications on RNA

Biophysical Reviews, v. 16, October 2023, p. 79-87
Goh, W. S. Sho; Kuang, Yi
Article

Intracellular Molecules Induced Extracellular Peptide Self-Assembly for Efficient and Effective In Situ Cell Purification

Angewandte Chemie - International Edition, v. 26, (37), 4 August 2023, article number e202306533
Li, Cheuk Yin; Liang, Zhenghua; Liu, Lejian; Kuang, Yi
Article

2022 3

Aptamer-Array-Guided Protein Assembly Enhances Synthetic mRNA Switch Performance

Angewandte Chemie - International Edition, v. 61, (34), August 2022, article number e202207319
Lu, Qiuyu; Hu, Yaxin; Li, Cheuk Yin; Kuang, Yi
Article

Cytidine-containing tails robustly enhance and prolong protein production of synthetic mRNA in cell and in vivo

Molecular Therapy - Nucleic Acids, v. 30, 13 December 2022, p. 300-310
Li, Cheuk Yin; Liang, Zhenghua; Hu, Yaxin; Zhang, Hongxia; Setiasabda, Kharis Daniel; Li, Jiawei; Ma, Shaohua; Xia, Xiaojun; Kuang, Yi
Article

Droplet-engineered organoids recapitulate parental tissue transcriptome with inter-organoid homogeneity and inter-tumor cell heterogeneity

Fundamental Research, June 2022
Zhao, Haoran; Cheng, Yifan; Li, Jiawei; Zhou, Jiaqi; Yang, Haowei; Yu, Feng; Yu, Feihong; Khutsishvili, Davit; Wang, Zitian; Jiang, Shengwei; Tan, Kaixin; Kuang, Yi; Xing, Xinhui; Ma, Shaohua
Article

2020 1

N¹-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells

Nucleic Acids Research, v. 48, (6), April 2020, p. e35
Parr, Callum J.C.; Wada, Shunsuke; Kotake, Kenjiro; Kameda, Shigetoshi; Matsuura, Satoshi; Sakashita, Souhei; Park, Soyoung; Sugiyaman, Hiroshi; Kuang, Becki Yi; Saito, Hirohide
Article

2018 1

Synthetic RNA-based Logic Computation in Mammalian Cells

Nature Communications, v. 9, (1), November 2018, article number 4847
Matsuura, Satoshi; Ono, Hiroki; Kawasaki, Shunsuke; Kuang, Yi; Fujita, Yoshihiko; Saito, Hirohide
Article

2017 2

Efficient, Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides

Cell Chemical Biology, v. 24, (6), June 2017, p. 685-694.e4
Kuang, Yi; Miki, Kenji; Parr, Callum J. C.; Hayashi, Karin; Takei, Ikue; Li, Jie; Iwasaki, Mio; Nakagawa, Masato; Yoshida, Yoshinori; Saito, Hirohide
Article

In Situ Generated D-peptidic Nanofibrils as Multifaceted Apoptotic Inducers to Target Cancer Cells

Cell Death and Disease, v. 8, (2), 2017, article number e2614
Du, Xuewen; Zhou, Jie; Wang, Huainin; Shi, Junfeng; Kuang, Yi; Zeng, Wu; Yang, Zhimou; Xu, Bing
Article

2016 2

MicroRna-302 Switch to Identify and Eliminate Undifferentiated Human Pluripotent Stem Cells

Scientific Reports, v. 6, September 2016, article number 32532
Parr, Callum J.C.; Katayama, Shota; Miki, Kenji; Kuang, Yi; Yoshida, Yoshinori; Morizane, Asuka; Takahashi, Jun B.; Yamanaka, Shinya; Saito, Hirohide
Article

Nanonets Collect Cancer Secretome from Pericellular Space

PLoS ONE, v. 11, (4), April 2016, article number e0154126
Zhou, Rong; Kuang, Yi; Zhou, Jie; Du, Xuewen; Li, Jie; Shi, Junfeng; Haburcak, Richard; Xu, Bing
Article

2015 1

Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells

Angewandte Chemie - International Edition, v. 54, (45), November 2015, p. 13307-13311
Li, Jie; Kuang, Yi; Shi, Junfeng; Zhou, Jie; Medina, Jamie E.; Zhou, Rong; Yuan, Dan; Yang, Cuihong; Wang, Huaimin; Yang, Zhimou; Liu, Jianfeng; Dinulescu, Daniela M.; Xu, Bing
Article

2014 5

Pericellular Hydrogel/Nanonets Inhibit Cancer Cells

Angewandte Chemie - International Edition, v. 53, (31), July 2014, p. 8104-8107
Kuang, Yi; Shi, Junfeng; Li, Jie; Yuan, Dan; Alberti, Kyle A.; Xu, Qiaobing; Xu, Bing
Article

Prion-like Nanofibrils of Small Molecules (PriSM) Selectively Inhibit Cancer Cells by Impeding Cytoskeleton Dynamics

Journal of Biological Chemistry, v. 289, (42), October 2014, p. 29208-29218
Kuang, Yi; Long, Marcus J. C.; Zhou, Jie; Shi, Junfeng; Gao, Yuan; Xu, Chen; Hedstrom, Lizbeth; Xu, Bing
Article

Supramolecular Nanofibrils Inhibit Cancer Progression In Vitro and In Vivo

Advanced Healthcare Materials, v. 3, (8), August 2014, p. 1217-1221
Kuang, Yi; Du, Xuewen; Zhou, Jie; Xu, Bing
Article

The First Supramolecular Peptidic Hydrogelator Containing Taurine

Chemical Communications, v. 50, (21), March 2014, p. 2772-2774
Kuang, Yi; Gao, Yuan; Shi, Junfeng; Li, Jie; Xu, Bing
Article

Biocompatibility of Hydrogelators Based on Small Peptide Derivatives

Hydrogels in Cell-Based Therapies / Edited by Che J Connon, and Ian W Hamley. Cambridge, United Kingdom : Royal Society Of Chemistry, 2014, p. 31-47, Ch. 2.
Kuang, Yi; Zhou, Ning; Xu, Bing
Book chapter

2013 10

A Redox Responsive, Fluorescent Supramolecular Metallohydrogel Consists of Nanofibers With Single-molecule Width

Journal of the American Chemical Society, v. 135, (13), April 2013, p. 5008-5011
Zhang, Ye; Zhang, Bei; Kuang, Yi; Gao, Yuan; Shi, Junfeng; Zhang, Xi Xiang; Xu, Bing
Article

Active Cross-linkers That Lead to Active Gels

Angewandte Chemie - International Edition, v. 52, (44), October 2013, p. 11494-11498
Zhang, Ye; Zhou, Ning; Akella, Sathish V.; Kuang, Yi; Kim, Dongshin; Schwartz, Alyssa; Bezpalko, Mark W.; Foxman, Bruce M.; Fraden, Seth; Epstein, Irving R.; Xu, Bing
Article

D-Amino Acids Boost the Selectivity and Confer Supramolecular Hydrogels of a Nonsteroidal Anti-Inflammatory Drug (NSAID)

Journal of the American Chemical Society, v. 135, (2), January 2013, p. 542-545
Li, Jiayang; Kuang, Yi; Gao, Yuan; Du, Xuewen; Shi, Junfeng; Xu, Bing
Article

Dephosphorylation of D-peptide Derivatives to Form Biofunctional, Supramolecular Nanofibers/hydrogels and Their Potential Applications for Intracellular Imaging and Intratumoral Chemotherapy

Journal of the American Chemical Society, v. 135, (26), July 2013, p. 9907-9914
Li, Jiayang; Gao, Yuan; Kuang, Yi; Shi, Junfeng; Du, Xuewen; Zhou, Jie; Wang, Huaimin; Yang, Zhimou; Xu, Bing
Article

Disruption of the Dynamics of Microtubules and Selective Inhibition of Glioblastoma Cells by Nanofibers of Small Hydrophobic Molecules

Angewandte Chemie - International Edition, v. 52, (27), July 2013, p. 6944-6948
Kuang, Yi; Xu, Bing
Article

Imaging Self-assembly Dependent Spatial Distribution of Small Molecules in Cellular Environment

Langmuir, v. 29, (49), December 2013, p. 15191-15200
Gao, Yuan; Kuang, Yi; Du, Xuewen; Zhou, Jie; Chandran, Preethi; Horkay, Ferenc; Xu, Bing
Article

Interactions Between Cellular Proteins and Morphologically Different Nanoscale Aggregates of Small Molecules

RSC Advances, v. 3, (21), June 2013, p. 7704-7707
Kuang, Yi; Yuan, Dan; Zhang, Ye; Kao, Anita; Du, Xuewen; Xu, Bing
Article

Probing Nanoscale Self-Assembly of Nonfluorescent Small Molecules inside Live Mammalian Cells

ACS Nano, v. 7, (10), October 2013, p. 9055-9063
Gao, Yuan; Berciu, Cristina; Kuang, Yi; Shi, Junfeng; Nicastro, Daniela; Xu, Bing
Article

Self-Delivery Multifunctional Anti-HIV Hydrogels for Sustained Release

Advanced Healthcare Materials, v. 2, (12), December 2013, p. 1586-1590
Li, Jiayang; Li, Xinming; Kuang, Yi; Gao, Yuan; Du, Xuewen; Shi, Junfeng; Xu, Bing
Article

The Conjugation of Nonsteroidal Anti-inflammatory Drugs (NSAID) to Small Peptides for Generating Multifunctional Supramolecular Nanofibers/hydrogels

Beilstein Journal of Organic Chemistry, v. 9, May 2013, p. 908-917
Li, Jiayang; Kuang, Yi; Shi, Junfeng; Gao, Yuan; Zhou, Jie; Xu, Bing
Article

2012 5

“Molecular Trinity” for Soft Nanomaterials: Integrating Nucleobases, Amino Acids, and Glycosides to Construct Multifunctional Hydrogelators

Soft Matter, v. 8, (10), March 2012, p. 2801-2806
Li, Xinming; Kuang, Yi; Xu, Bing
Article

Catalytic Dephosphorylation of Adenosine Monophosphate (AMP) to Form Supramolecular Nanofibers/hydrogels

Chemical Communications, v. 48, (15), February 2012, p. 2098-2100
Du, Xuewen; Li, Junfeng; Gao, Yuan; Kuang, Yi; Xu, Bing
Article

Post-self-assembly Cross-linking of Molecular Nanofibers for Oscillatory Hydrogels

Langmuir, v. 28, (6), February 2012, p. 3063-3066
Zhang, Ye; Li, Ning; Delgado, Jorge; Gao, Yuan; Kuang, Yi; Fraden, Seth; Epstein, Irving R.; Xu, Bing
Article

Supramolecular Hydrogel of Kanamycin Selectively Sequesters 16S rRNA

Chemical Communications, v. 48, (74), September 2012, p. 9257-9259
Yang, Zhimou; Kuang, Yi; Li, Xinming; Zhou, Ning; Zhang, Ye; Xu, Bing
Article

Supramolecular Hydrogels Formed by the Conjugates of Nucleobases, Arg-Gly-Asp (RGD) Peptides, and Glucosamine

Soft Matter, v. 8, (28), July 2012, p. 7402-7404
Li, Xinming; Du, Xuewen; Gao, Yuan; Shi, Junfeng; Kuang, Yi; Xu, Bing
Article

2011 5

Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only of Nucleobase, Amino Acid, and Glycoside

Journal of the American Chemical Society, v. 133, (43), November 2011, p. 17513-17518
Li, Xinming; Kuang, Yi; Shi, Junfeng; Gao, Yuan; Lin, Hsin-Chieh; Xu, Bing
Article

Supramolecular Hydrogelators of N-terminated Dipeptides Selectively Inhibit Cancer Cells

Chemical Communications, v. 47, (47), December 2011, p. 12625-12627
Kuang, Yi; Gao, Yuan; Xu, Bing
Article

Supramolecular Hydrogels Based on the Epitope of Potassium Ion Channels

Chemical Communications, v. 47, (31), August 2011, p. 8772-8774
Kuang, Yi; Gao, Yuan; Shi, Junfeng; Lin, Hsin-Chieh; Xu, Bing
Article

Supramolecular Nanofibers and Hydrogels of Nucleopeptides

Angewandte Chemie - International Edition, v. 50, (40), September 2011, p. 9365-9369
Li, Xinming; Kuang, Yi; Lin, Hsin-Chieh; Gao, Yuan; Shi, Junfeng; Xu, Bing
Article

Versatile Small-molecule Motifs for Self-assembly in Water and the Formation of Biofunctional Supramolecular Hydrogels

Langmuir, v. 27, (2), January 2011, p. 529-537
Zhang, Ye; Kuang, Yi; Gao, Yuan; Xu, Bing
Article

2010 4

Aromatic-Aromatic Interactions Induce the Self-Assembly of Pentapeptidic Derivatives in Water To Form Nanofibers and Supramolecular Hydrogels

Journal of the American Chemical Society, v. 132, (8), February 2010, p. 2719-2728
Ma, Nlung; Kuang, Yi; Gao, Yuan; Zhang, Yan; Gao, Ping; Xu, Bing
Article

Enzymatic Formation of a Photoresponsive Supramolecular Hydrogel

Chemical Communications, v. 46, (29), 2010, p. 5364-5366
Li, Xinming; Gao, Yuan; Kuang, Yi; Xu, Bing
Article

Enzyme-instructed Self-assembly of Peptide Derivatives to Form Nanofibers and Hydrogels

Biopolymers, v. 94, (1), January 2010, p. 19-31
Gao, Yuan; Yang, Zhimou; Kuang, Yi; Ma, Man-Lung; Li, Jiayang; Zhao, Fan; Xu, Bing
Article

Molecular Nanofibers of Olsalazine Form Supramolecular Hydrogels for Reductive Release of an Anti-inflammatory Agent

Journal of the American Chemical Society, v. 132, (50), December 2010, p. 17707-17709
Li, Xinming; Li, Jiayang; Gao, Yuan; Kuang, Yi; Shi, Junfeng; Xu, Bing
Article

2009 2

Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative

Journal of the American Chemical Society, v. 131, (38), September 2009, p. 13576-13577
Gao, Yuan; Kuang, Yi; Guo, Zufeng; Guo, Zhihong; Krauss, Isaac J.; Xu, Bing
Article

Supramolecular Hydrogel of a D-Amino Acid Dipeptide for Controlled Drug Release in Vivo

Langmuir, v. 25, (15), August 2009, p. 8419-8422
Liang, Gaolin; Yang, Zhimou; Zhang, Rongjun; Li, Lihua; Fan, Yijun; Kuang, Yi; Gao, Yuan; Wang, Ting; Lu, W. William; Xu, Bing
Article

2008 1

Multifunctional Yolk-shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent

Journal of the American Chemical Society, v. 130, (35), September 2008, p. 11828-11833
Gao, Jinhao; Liang, Gaolin; Cheung, Jerry S.; Pan, Yue; Kuang, Yi; Zhao, Fan; Zhang, Bei; Zhang, Xixiang; Wu, Ed X.; Xu, Bing
Article

2007 2

FePt@CoS2 Yolk-shell Nanocrystals as a Potent Agent to Kill HeLa Cells

Journal of the American Chemical Society, v. 129, (5), February 2007, p. 1428-1433
Gao, Jinhao; Liang, Gaolin; Zhang, Bei; Kuang, Yi; Zhang, Xixiang; Xu, Bing
Article

Using Congo Red to Report Intracellular Hydrogelation Resulted From Self-assembly of Small Molecules

Chemical communications, (40), 2007, p. 4096-4098
Liang, Gaolin; Xu, Keming; Li, Lihua; Wang, Ling; Kuang, Yi; Yang, Zhimou; Xu, Bing
Article

BIEN2610	Chemical Biology for Engineers
BIEN3910	Bioengineering Laboratory
UROP1100N	Undergraduate Research Opportunities Series 1

BIEN2410	Cellular and Systems Physiology for Engineers
CENG3150	Integrated Chemical Process and Product Design
UROP3200	Undergraduate Research Opportunities with Mini-conference Experience

BIEN2610	Chemical Biology for Engineers
BIEN3910	Bioengineering Laboratory
UROP1100K	Undergraduate Research Opportunities Series 1

Research Interest

Publications

2024 4

2023 3

2022 3

2020 1

2018 1

2017 2

2016 2

2015 1

2014 5

2013 10

2012 5

2011 5

2010 4

2009 2

2008 1

2007 2

Article 4

Article 3

Article 3

Article 1

Article 1

Article 2

Article 2

Article 1

Article 4

Book chapter 1

Article 10

Article 5

Article 5

Article 4

Article 2

Article 1

Article 2

2018 1

2017 2

2016 2

2015 1

2014 5

2013 10

2012 5

2011 5

2010 4

2009 2

2008 1

2007 2

Teaching Assignment

Research Postgraduate (RPG) Supervision

From January 2021 to December 2024 (As of 21 November 2024)

Current RPGs

Graduated RPGs

Projects

From January 2022 to December 2024

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