Faculty Profiles - CHENG Aifang | The Hong Kong University of Science and Technology

Aifang CHENG
程愛芳

PhD in Life Science
The Hong Kong University of Science and Technology, 2018

Research Assistant Professor
Department of Ocean Science

chengaf@ust.hk
Room 3642

ORCID

0000-0002-5022-418X

Scopus ID

56493908600

Research Interest Publications Projects Teaching Assignment

Research Interest

Neuroscience
Neurodegenerative disease
Marine bacteria
Cellular and molecular mechanisms
Molecular medicine

Publications

All Years 26 2023 2 2022 4 2021 4 2020 1 2019 3 2018 3 2017 9

2023 2

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Neuron, v. 111, (2), January 2023, p. 236-255
Wang, Xu; Yang, Chao; Wang, Xuejie; Miao, Jinmin; Chen, Weitao; Zhou, Yiren; Xu, Ying; An, Yongyan; Cheng, Aifang; Ye, Wenkang; Chen, Mengxian; Song, Dong; Yuan, Xue; Wang, Jiguang; Qian, Peiyuan; Wu, Angela Ruohao; Zhang, Zhong-Yin; Liu, Kai
Article

Pterosin sesquiterpenoids from Pteris laeta Wall. ex Ettingsh. protect cells from glutamate excitotoxicity by modulating mitochondrial signals

Journal of ethnopharmacology, v. 308, 23 May 2023, article number 116308
Cheng, Aifang; Zhang, Yan; Sun, Jin; Huang, Duli; Sulaiman, Jordy Evan; Huang, Xin; Wu, Long; Ye, Wenkang; Wu, Chuanhai; Lam, Hei Ning; Shi, Yusheng; Qian, Peiyuan
Article

2022 4

Discovery, Yield Improvement, and Application in Marine Coatings of Potent Antifouling Compounds Albofungins Targeting Multiple Fouling Organisms

Frontiers in Microbiology, v. 13, 7 July 2022, article number 906345
She, Weiyi; Ye, Wei; Cheng, Aifang; Ye, Wenkang; Ma, Chunfeng; Wang, Ruojun; Cheng, Jinping; Liu, Xuan; Yuan, Yujing; Chik, Sin Yu; Malit, Jessie James Limlingan; Lu, Yanhong; Chen, Feng; Qian, Peiyuan
Article

Marine biofilms: diversity, interactions and biofouling

Nature Reviews Microbiology, 25 May 2022
Qian, Peiyuan; Cheng, Aifang; Wang, Ruojun; Zhang, Rui
Article

Mode of action of elasnin as biofilm formation eradicator of methicillin-resistant Staphylococcus aureus

Frontiers in Microbiology, v. 13, 8 August 2022, article number 967845
Long, Lexin; Sulaiman, Jordy Evan; Xiao, Yao; Cheng, Aifang; Wang, Ruojun; Malit, Jessie James Limlingan; Wong, Wai Chuen; Liu, Wenchao; Li, Yong-Xin; Chen, Feng; Lam, Hei Ning; Qian, Peiyuan
Article

Selective C9orf72 G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models

Journal of Medicinal Chemistry, v. 65, (19), 15 September 2022, p. 12825-12837
Cheng, Aifang; Liu, Changdong; Ye, Wenkang; Huang, Duli; She, Weiyi; Liu, Xin; Fung, Chun Po; Xu, Naining; Suen, Ching Monica; Ye, Wei; Sung, Herman Ho Yung; Williams, Ian Duncan; Zhu, Guang; Qian, Peiyuan
Article

2021 4

Discovery, Bioactivity Evaluation, Biosynthetic Gene Cluster Identification, and Heterologous Expression of Novel Albofungin Derivatives

Frontiers in Microbiology, v. 12, February 2021, article number 635268
She, Weiyi; Ye, Wenkang; Cheng, Aifang; Liu, Xin; Tang, Jianwei; Lan, Yi; Chen, Feng; Qian, Peiyuan
Article

Global Genome Mining Reveals a Cytochrome P450-Catalyzed Cyclization of Crownlike Cyclodipeptides with Neuroprotective Activity

Organic Letters, v. 23, (17), April 2021, p. 6601-6605
Malit, Jessie James Limlingan; Liu, Wenchao; Cheng, Aifang; Saha, Subhasish; Liu, Lingli; Qian, Peiyuan
Article

Hologenome analysis reveals dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis

Nature Communications, v. 12, (1), February 2021, article number 1165
Lan, Yi; Sun, Jin; Chen, Chong; Sun, Yanan; Zhou, Yadong; Yang, Yi; Zhang, Weipeng; Li, Runsheng; Zhou, Kun; Wong, Wai Chuen; Kwan, Yick Hang; Cheng, Aifang; Bougouffa, Salim; Van Dover, Cindy Lee; Qiu, Jian-Wen; Qian, Peiyuan
Article

Myelin pathology in ataxia-telangiectasia is the cell-intrinsic consequence of ATM deficiency in the oligodendrocytes

MedRxiv, January 2021
Tse, Kai-Hei; Cheng, Aifang; Yeung, Sunny Hoi-Sang; Cheng, Gerald Wai-Yeung; Wang, Qingyang; Zhu, Beika; Cui, Yong; Jiang, Liwen; Kofler, Julia; Herrup, Karl
Article

2020 1

ATM loss disrupts the autophagy-lysosomal pathway

Autophagy, August 2020
Cheng, Aifang; Tse, Kai-Hei; Chow, Hei-Man; Gan, Yunqiao; Song, Xuan; Ma, Fulin; Qian, Yi Xuan Yvonne; She, Weiyi; Herrup, Karl
Article

2019 3

Age-related Hyperinsulinemia Leads to Insulin Resistance in Neurons and Cell-cycle-induced Senescence

Nature Neuroscience, v. 22, (11), November 2019, p. 1806-1819
Chow, Hei Man; Shi, Meng; Cheng, Aifang; Gao, Yuehong; Chen, Guimiao; Song, Yixuan; So, Wai Lam Raphaella; Zhang, Jie; Herrup, Karl
Article

ATM is Activated by ATP Depletion and Modulates Mitochondrial Function Through NRF1

Journal of Cell Biology, v. 218, (3), March 2019, p. 909-928
Chow, Hei Man; Cheng, Aifang; Song, Xuan; Swerdel, Mavis R.; Hart, Ronald, P.; Herrup, Karl
Article

Insulin resistant neurons arisen from peripheral hyperinsulinemia are senescent and correlate with memory impairment and cognitive decline: implications for Alzheimer's disease

Alzheimer's and Dementia, v. 15, (7S, pt. 6), July 2019, article number P-184, p. 307
Chow, Hei Man; Shi, Meng; Zhang, Jie; Chen, Guimiao; Cheng, Aifang; Song, Xuan; So, Raphaella Wai Lam; Herrup, Karl
Conference paper

2018 3

ATM and ATR Play Complementary Roles in the Behavior of Excitatory and Inhibitory Vesicle Populations

Proceedings of the National Academy of Sciences of the United States of America (PNAS), v. 115, (2), January 2017, p. E292-E301
Cheng, Aifang; Zhao, Teng; Tse, Kai Hei; Chow, Hei Man; Cui, Yong; Jiang, Liwen; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl
Article

DNA Damage-associated Oligodendrocyte Degeneration Precedes Amyloid Pathology and Contributes to Alzheimer's Disease and Dementia

Alzheimers & Dementia, v. 14, (5), May 2018, p. 664-679
Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Herrup, Karl
Article

ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

Chow, Hei Man; Cheng, Aifang; Song, Xuan; Swerdel, M.; Hart, Ronald P.; Herrup, Karl
Conference paper

2017 1

Insulin resistance mediates neuronal cell cycle re-entry, dysfunction and degeneration

Chow, Hei Man; Cheng, Aifang; Herrup, Karl
Conference paper

2016 4

ATM Protein is Located on Presynaptic Vesicles and its Deficit Leads to Failures in Synaptic Plasticity

Journal of Neurophysiology, v. 116, (1), July 2016, p. 201-209
Vail, Graham; Cheng, Aifang; Han, Yu Ray; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl; Plummer, Mark R.
Article

Multicolor 4D fluorescence microscopy using ultrathin bessel light sheets

Scientific Reports, v. 6, May 2016, article number 26159
Zhao, Teng; Lau, Sze Cheung; Wang, Ying; Su, Yumian; Wang, Hao; Cheng, Aifang; Herrup, Karl; Ip, Nancy Y.; Du, Shengwang; Loy, M.M.T.
Article

A Robust Two-Color Super-Resolution Localization Microscope

Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng
Conference paper

DNA damage-associated loss of cortical oligodendrocytes in dementia and Alzheimer's disease

Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Chow, Hei Man; Herrup, Karl
Conference paper

2015 2

A User-Friendly Two-Color Super-Resolution Localization Microscope

Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak
Article

White matter degeneration and aberrant oligodendrocyte differentiation during the progress of Alzheimer’s disease

Tse, Kai Hei; Cheng, Aifang; Chow, Hei Man; Herrup, Karl
Conference paper

2014 1

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress

Journal of Medicinal Food, v. 17, (5), May 2014, p. 535-542
Ai, Zhong; Cheng, Ai-Fang; Yu, Yuan-Tao; Yu, Long-Jiang; Jin, Wenwen
Article

2012 1

国产玛咖芥子油苷的组分分析和含量测定

食品科技=Food Science and Technology, v. 37, (4), 2012, p. 182-186
艾中; 程爱芳; 孟际勇; 刘浩; 余龙江; 金文闻
Article

Article 2

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Neuron, v. 111, (2), January 2023, p. 236-255
Wang, Xu; Yang, Chao; Wang, Xuejie; Miao, Jinmin; Chen, Weitao; Zhou, Yiren; Xu, Ying; An, Yongyan; Cheng, Aifang; Ye, Wenkang; Chen, Mengxian; Song, Dong; Yuan, Xue; Wang, Jiguang; Qian, Peiyuan; Wu, Angela Ruohao; Zhang, Zhong-Yin; Liu, Kai

Pterosin sesquiterpenoids from Pteris laeta Wall. ex Ettingsh. protect cells from glutamate excitotoxicity by modulating mitochondrial signals

Journal of ethnopharmacology, v. 308, 23 May 2023, article number 116308
Cheng, Aifang; Zhang, Yan; Sun, Jin; Huang, Duli; Sulaiman, Jordy Evan; Huang, Xin; Wu, Long; Ye, Wenkang; Wu, Chuanhai; Lam, Hei Ning; Shi, Yusheng; Qian, Peiyuan

Article 4

Discovery, Yield Improvement, and Application in Marine Coatings of Potent Antifouling Compounds Albofungins Targeting Multiple Fouling Organisms

Frontiers in Microbiology, v. 13, 7 July 2022, article number 906345
She, Weiyi; Ye, Wei; Cheng, Aifang; Ye, Wenkang; Ma, Chunfeng; Wang, Ruojun; Cheng, Jinping; Liu, Xuan; Yuan, Yujing; Chik, Sin Yu; Malit, Jessie James Limlingan; Lu, Yanhong; Chen, Feng; Qian, Peiyuan

Marine biofilms: diversity, interactions and biofouling

Nature Reviews Microbiology, 25 May 2022
Qian, Peiyuan; Cheng, Aifang; Wang, Ruojun; Zhang, Rui

Mode of action of elasnin as biofilm formation eradicator of methicillin-resistant Staphylococcus aureus

Frontiers in Microbiology, v. 13, 8 August 2022, article number 967845
Long, Lexin; Sulaiman, Jordy Evan; Xiao, Yao; Cheng, Aifang; Wang, Ruojun; Malit, Jessie James Limlingan; Wong, Wai Chuen; Liu, Wenchao; Li, Yong-Xin; Chen, Feng; Lam, Hei Ning; Qian, Peiyuan

Selective C9orf72 G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models

Journal of Medicinal Chemistry, v. 65, (19), 15 September 2022, p. 12825-12837
Cheng, Aifang; Liu, Changdong; Ye, Wenkang; Huang, Duli; She, Weiyi; Liu, Xin; Fung, Chun Po; Xu, Naining; Suen, Ching Monica; Ye, Wei; Sung, Herman Ho Yung; Williams, Ian Duncan; Zhu, Guang; Qian, Peiyuan

Article 4

Discovery, Bioactivity Evaluation, Biosynthetic Gene Cluster Identification, and Heterologous Expression of Novel Albofungin Derivatives

Frontiers in Microbiology, v. 12, February 2021, article number 635268
She, Weiyi; Ye, Wenkang; Cheng, Aifang; Liu, Xin; Tang, Jianwei; Lan, Yi; Chen, Feng; Qian, Peiyuan

Global Genome Mining Reveals a Cytochrome P450-Catalyzed Cyclization of Crownlike Cyclodipeptides with Neuroprotective Activity

Organic Letters, v. 23, (17), April 2021, p. 6601-6605
Malit, Jessie James Limlingan; Liu, Wenchao; Cheng, Aifang; Saha, Subhasish; Liu, Lingli; Qian, Peiyuan

Hologenome analysis reveals dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis

Nature Communications, v. 12, (1), February 2021, article number 1165
Lan, Yi; Sun, Jin; Chen, Chong; Sun, Yanan; Zhou, Yadong; Yang, Yi; Zhang, Weipeng; Li, Runsheng; Zhou, Kun; Wong, Wai Chuen; Kwan, Yick Hang; Cheng, Aifang; Bougouffa, Salim; Van Dover, Cindy Lee; Qiu, Jian-Wen; Qian, Peiyuan

Myelin pathology in ataxia-telangiectasia is the cell-intrinsic consequence of ATM deficiency in the oligodendrocytes

MedRxiv, January 2021
Tse, Kai-Hei; Cheng, Aifang; Yeung, Sunny Hoi-Sang; Cheng, Gerald Wai-Yeung; Wang, Qingyang; Zhu, Beika; Cui, Yong; Jiang, Liwen; Kofler, Julia; Herrup, Karl

Article 1

ATM loss disrupts the autophagy-lysosomal pathway

Autophagy, August 2020
Cheng, Aifang; Tse, Kai-Hei; Chow, Hei-Man; Gan, Yunqiao; Song, Xuan; Ma, Fulin; Qian, Yi Xuan Yvonne; She, Weiyi; Herrup, Karl

Article 2

Age-related Hyperinsulinemia Leads to Insulin Resistance in Neurons and Cell-cycle-induced Senescence

Nature Neuroscience, v. 22, (11), November 2019, p. 1806-1819
Chow, Hei Man; Shi, Meng; Cheng, Aifang; Gao, Yuehong; Chen, Guimiao; Song, Yixuan; So, Wai Lam Raphaella; Zhang, Jie; Herrup, Karl

ATM is Activated by ATP Depletion and Modulates Mitochondrial Function Through NRF1

Journal of Cell Biology, v. 218, (3), March 2019, p. 909-928
Chow, Hei Man; Cheng, Aifang; Song, Xuan; Swerdel, Mavis R.; Hart, Ronald, P.; Herrup, Karl

Conference paper 1

Insulin resistant neurons arisen from peripheral hyperinsulinemia are senescent and correlate with memory impairment and cognitive decline: implications for Alzheimer's disease

Alzheimer's and Dementia, v. 15, (7S, pt. 6), July 2019, article number P-184, p. 307
Chow, Hei Man; Shi, Meng; Zhang, Jie; Chen, Guimiao; Cheng, Aifang; Song, Xuan; So, Raphaella Wai Lam; Herrup, Karl

Article 2

ATM and ATR Play Complementary Roles in the Behavior of Excitatory and Inhibitory Vesicle Populations

Proceedings of the National Academy of Sciences of the United States of America (PNAS), v. 115, (2), January 2017, p. E292-E301
Cheng, Aifang; Zhao, Teng; Tse, Kai Hei; Chow, Hei Man; Cui, Yong; Jiang, Liwen; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl

DNA Damage-associated Oligodendrocyte Degeneration Precedes Amyloid Pathology and Contributes to Alzheimer's Disease and Dementia

Alzheimers & Dementia, v. 14, (5), May 2018, p. 664-679
Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Herrup, Karl

Conference paper 1

ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

Chow, Hei Man; Cheng, Aifang; Song, Xuan; Swerdel, M.; Hart, Ronald P.; Herrup, Karl

Conference paper 1

Insulin resistance mediates neuronal cell cycle re-entry, dysfunction and degeneration

Chow, Hei Man; Cheng, Aifang; Herrup, Karl

Article 2

ATM Protein is Located on Presynaptic Vesicles and its Deficit Leads to Failures in Synaptic Plasticity

Journal of Neurophysiology, v. 116, (1), July 2016, p. 201-209
Vail, Graham; Cheng, Aifang; Han, Yu Ray; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl; Plummer, Mark R.

Multicolor 4D fluorescence microscopy using ultrathin bessel light sheets

Scientific Reports, v. 6, May 2016, article number 26159
Zhao, Teng; Lau, Sze Cheung; Wang, Ying; Su, Yumian; Wang, Hao; Cheng, Aifang; Herrup, Karl; Ip, Nancy Y.; Du, Shengwang; Loy, M.M.T.

Conference paper 2

A Robust Two-Color Super-Resolution Localization Microscope

Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng

DNA damage-associated loss of cortical oligodendrocytes in dementia and Alzheimer's disease

Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Chow, Hei Man; Herrup, Karl

Article 1

A User-Friendly Two-Color Super-Resolution Localization Microscope

Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak

Conference paper 1

White matter degeneration and aberrant oligodendrocyte differentiation during the progress of Alzheimer’s disease

Tse, Kai Hei; Cheng, Aifang; Chow, Hei Man; Herrup, Karl

Article 1

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress

Journal of Medicinal Food, v. 17, (5), May 2014, p. 535-542
Ai, Zhong; Cheng, Ai-Fang; Yu, Yuan-Tao; Yu, Long-Jiang; Jin, Wenwen

Article 1

国产玛咖芥子油苷的组分分析和含量测定

食品科技=Food Science and Technology, v. 37, (4), 2012, p. 182-186
艾中; 程爱芳; 孟际勇; 刘浩; 余龙江; 金文闻

2017 1

Insulin resistance mediates neuronal cell cycle re-entry, dysfunction and degeneration

Chow, Hei Man; Cheng, Aifang; Herrup, Karl
Conference paper

2016 4

ATM Protein is Located on Presynaptic Vesicles and its Deficit Leads to Failures in Synaptic Plasticity

Journal of Neurophysiology, v. 116, (1), July 2016, p. 201-209
Vail, Graham; Cheng, Aifang; Han, Yu Ray; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl; Plummer, Mark R.
Article

Multicolor 4D fluorescence microscopy using ultrathin bessel light sheets

Scientific Reports, v. 6, May 2016, article number 26159
Zhao, Teng; Lau, Sze Cheung; Wang, Ying; Su, Yumian; Wang, Hao; Cheng, Aifang; Herrup, Karl; Ip, Nancy Y.; Du, Shengwang; Loy, M.M.T.
Article

A Robust Two-Color Super-Resolution Localization Microscope

Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng
Conference paper

DNA damage-associated loss of cortical oligodendrocytes in dementia and Alzheimer's disease

Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Chow, Hei Man; Herrup, Karl
Conference paper

2015 2

A User-Friendly Two-Color Super-Resolution Localization Microscope

Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak
Article

White matter degeneration and aberrant oligodendrocyte differentiation during the progress of Alzheimer’s disease

Tse, Kai Hei; Cheng, Aifang; Chow, Hei Man; Herrup, Karl
Conference paper

2014 1

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress

Journal of Medicinal Food, v. 17, (5), May 2014, p. 535-542
Ai, Zhong; Cheng, Ai-Fang; Yu, Yuan-Tao; Yu, Long-Jiang; Jin, Wenwen
Article

2012 1

国产玛咖芥子油苷的组分分析和含量测定

食品科技=Food Science and Technology, v. 37, (4), 2012, p. 182-186
艾中; 程爱芳; 孟际勇; 刘浩; 余龙江; 金文闻
Article

Teaching Assignment

2022-23 Spring 0 2022-23 Winter 0 2022-23 Fall 0 2021-22 Summer 0 2021-22 Spring 1 2021-22 Winter 0

OCES6011B

Postgraduate Seminar

No Teaching Assignments

Projects

From January 2021 to December 2023

All Projects 1

No Projects.
Mechanistic study of first-in-class selective G-quadruplex-binding small molecules ameliorating multiple pathological signatures in C9orf72 ALS/FTD cellular and animal models

對新型選擇性結合G-四鏈體的小分子其緩解C9orf72基因關聯的漸凍癥/額顳葉癡呆癥的細胞和動物模型多重病理特征的作用機制研究 Leading

RGC - General Research Fund
Project Team (HKUST)
CHENG Aifang (Lead)

QIAN Peiyuan
2022 -

Research Interest

Publications

2023 2

2022 4

2021 4

2020 1

2019 3

2018 3

2017 1

2016 4

2015 2

2014 1

2012 1

Article 2

Article 4

Article 4

Article 1

Article 2

Conference paper 1

Article 2

Conference paper 1

Conference paper 1

Article 2

Conference paper 2

Article 1

Conference paper 1

Article 1

Article 1

2017 1

2016 4

2015 2

2014 1

2012 1

Teaching Assignment

Projects

From January 2021 to December 2023

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